Latent Class Analysis - Harvard University

[Pages:43]Latent Class Analysis

Karen Bandeen-Roche October 27, 2016

Objectives

For you to leave here knowing...

? When is latent class analysis (LCA) model useful? ? What is the LCA model its underlying assumptions?

? How are LCA parameters interpreted?

? How are LCA parameters commonly estimated?

? How is LCA fit adjudicated?

? What are considerations for identifiability / estimability?

Motivating Example

Frailty of Older Adults

"...the sixth age shifts into the lean and slipper'd pantaloon, with spectacles on nose and pouch on side, his youthful hose well sav'd, a world too wide, for his shrunk shank..."

-- Shakespeare, "As You Like It"

The Frailty Construct

Fried et al., J Gerontol 2001; Bandeen-Roche et al., J Gerontol, 2006

Frailty as a latent variable

? "Underlying": status or degree of syndrome

? "Surrogates": Fried et al. (2001) criteria

? weight loss above threshold ? low energy expenditure ? low walking speed ? weakness beyond threshold ? exhaustion

Part I:

Model

Latent class model

1 Y1

...

Ym

Frailty

m

Measurement

Structural

Well-used latent variable models

Latent variable scale

Observed variable scale Continuous Discrete

Continuous Factor analysis Discrete FA

LISREL

IRT (item response)

Discrete Latent profile Latent class Growth mixture analysis, regression

General software: MPlus, Latent Gold, WinBugs (Bayesian), NLMIXED (SAS)

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