AACR Journals
The crystal structure of human IgG1 (publicly available at Sondermann et al., 2000, Nature 406:267-273; PDB code 3DO3, 10.2210/pdb3do3/pdb) was used to predict, using structural modeling, the positions where the reactive cysteines should be introduced for optimal conjugation with a sulfhydryl reactive agent. ................
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