Lippincott Williams & Wilkins



Appendix 1. Anesthetic monitoring in double-blind randomized controlled trials of intravenous ketamine infusions for chronic pain syndromesStudyClinical settingKetamine infusionObservation periodDepth of sedationArterial pressurePulse oximetryECGCapnometryCommentsBackonja 1994195IP0.25 mg/kg over 5-minOvernightSedation assessed, method NRYesNRNRNRHR monitored, specific method NREide 1994156NR0.15 mg/kg over 10-minNRNRNRNRNRNRHR changes reported but method of monitoring NRMax 1995151NR0.75 mg/kg/hr for 2 hoursNRSedation assessed, method NRNRNRNRNR-Eide 1995153NR60 mcg/kg bolus over 1 min, then 6 mcg/kg/min (0.36 mg/kg/hr) for 17-21 minNRNRNRNRNRNRHR changes reported but method of monitoring NRSorensen 1995157OP0.3 mg/kg over 10 minutes4 hours following infusionNRYesNRYesNR-Felsby 1996196NR0.2 mg/kg over 10 minutes, then 0.3 mg/kg/hr for 1 hour Sedation assessed, method NR YesNRNRNRHR assessed, method NRNikolajsen 1996155NR2 sessions of 0.1 mg/kg over 5 minutes, then 7 mcg/kg/min (0.42 mg/kg/hr) for up to 45 minutesNRNRYesNRYesNR-Sorensen 1997158NR0.3 mg/kg for 30 minutesNRNRYesNRYesNRRR assessed, method of monitoring NRPersson 1998162NR0.15, or 0.3, or 0.45 mg/kg over 5 minutesNRSedation assessed, method NRYesNRYesNR-Graven-Nielsen 200021NR0.3 mg/kg over 30-minNRSedation assessed by “reaction time” to audible stimuliYesNRYesNR“Reaction time” increased following infusionLeung 200144NR3 target serum concentrations of 50, 100, 150 ng/ml; infusion given for 20 minutesNRSedation assessed, method NRYesYesYesNRKetamine dose NRMitchell 2002161IP0.6 mg/kg over 4 hoursNRNRNRNRNRNRNo information about monitoringJorum 2003197NR60 mcg/kg bolus over 5 minutes, then 6 mcg/kg/min (0.36 mg/kg/hr) for 20 minutesNRNRNRNRNRNRNo information about monitoringKvarnstr?m 2003117NR0.4 mg/kg over 40 minutes4 hoursSedation assessed, method NRNRNRNRNRNo information about monitoringKvarnstr?m 2004118NR0.4 mg/kg over 40 minutes 4 hoursSedation assessed, method NRNRNRNRNRNo information about monitoringGottrup 2006152NR0.1 mg/kg bolus over 10 minutes, then 0.007 mg/kg/min (0.42 mg/kg/hr) for 20 minutesNRNRYesNRYesNR-Eichenberger 2008116NR0.4 mg/kg over 1 hourNRAssessed using 5-point Likert scaleYesYesYesNR-Schwartzman 2009122NR0.35 mg/kg/hr over 4 hours, daily for 10 daysNRNRYesYesYes NR-Sigtermans 2009160IPMean dose 22 mg/hr over mean of 4.2 days5-day IPNRYesNRNRNRBlood pressured measured 3 times dailyAmr 2010154IP80 mg over 5-hours daily for 7 daysNot reportedNot reportedYesYesYesNot reported-Noppers 2011159 OP0.5 mg/kg for 30 minutes2.5 hoursNoneYesYesNRNRHR and RR were monitored but method NRECG: Electrocardiography; HR: Heart rate; IP: Inpatient; NR: Not reported; OP: Outpatient; RR: Respiratory rate ................
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