Drugs for the Cardiovascular System

very sensitive to ACE inhibitors (eg captopril) ↓ BP due to ↑ kinin activity (NOT due to ↓ AII) but could cause collapse of GFR ( AII constricts efferent arteriole to maintain GFR with ↓ blood flow, if remove AII ( collapse GFR. AT1 receptor antagonists (e.g. losartan) also ↓ BP (still be careful of effect on GFR) Darrow-Yannet diagrams ................
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