June 15, 2000 Bethany B
Bethany Beilue Moore
Professor of Internal Medicine with tenure
Professor of Microbiology and Immunology without tenure
4053 BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109-2200
Phone: 734-647-8378
Fax: 734-615-2331
Email: Bmoore@umich.edu
Title and Contents Page 1
Education and Training Page 2
Academic Appointments Pages 2-3
Research Interests Page 3-4
Grants Pages 4-10
Honors and Awards Page 10
Membership in Professional Societies Page 10-11
Editorial Positions, Boards and Peer-Review Service Pages 11-13
Teaching and Mentoring Pages 13-20
Committee, Organizational, and Volunteer Service Pages 20-22
Consulting Positions Page 22
Visiting Professorships, Seminars, and Extramural Invited
Presentations Pages 22-27
Bibliography Pages 27-37
Recent Abstracts Page 38-39
Education and Training
8/82-5/86 University of Texas, Austin, Texas
Major: Microbiology: B.A.
8/86-4/92 University of Texas Southwestern Medical Center, Dallas, Texas,
Major: Immunology, Ph.D.
Dissertation Title: “Regulatory Elements Necessary for Termination of Transcription within the Immunoglobulin Heavy Chain Gene Locus”
Advisor: Dr. Dorothy Yuan
Conferred: April 15, 1992
5/92-3/94 Postdoctoral Fellow
University of Texas Southwestern Medical Center Department of Internal Medicine/Rheumatology
Dr. Katheryn Meek's laboratory
Field: Immunoglobulin VDJ rearrangement
3/94-11/95 Postdoctoral Fellow Stanford University
Department of Biological Sciences
Dr. Patricia Jones laboratory
Field: Invariant chain gene regulation
11/95-3/97 Postdoctoral Fellow
Stanford University School of Medicine Department of Medicine/Immunology
Dr. C. Garrison Fathman's laboratory
Field: T cell anergy and autoimmunity
Academic and Administrative Appointments
3/97-8/00 Research Investigator
University of Michigan
Department of Internal Medicine
9/00-8/03 Assistant Research Scientist
University of Michigan
Department of Internal Medicine
Division of Pulmonary and Critical Care Medicine
9/03-8/06 Assistant Professor
University of Michigan
Department of Internal Medicine
Division of Pulmonary and Critical Care Medicine
9/06-8/11 Associate Professor with tenure
University of Michigan
Department of Internal Medicine
Division of Pulmonary and Critical Care Medicine
9/09-8/11 Joint appointment as Associate Professor to the University of Michigan, Department of Microbiology and Immunology
9/11-present Full professor with tenure
University of Michigan
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine
Full professor without tenure in the department of Microbiology and Immunology
8/12-present Director, Immunology Graduate Program
University of Michigan
Research Interests
My laboratory has two basic areas of interest. The first is the pathogenesis of fibrotic lung disease. The second is pulmonary host defense following bone marrow transplantation (BMT). Specific interests in these areas are as follows:
Fibrotic Lung Disease:
1) The role of chemokines and eicosanoids in the pathogenesis of experimental fibrosis
2) The role of circulating fibrocytes in the pathogenesis of fibrosis
3) The role of viral infections in the exacerbation of experimental fibrosis
4) Epithelial/fibroblast interactions in fibrosis
5) Viral-induced fibrosis in the aged lung
Host Defense post-BMT:
1) The role of eicosanoids in regulating alveolar macrophage and neutrophil function post-BMT
2) Reconstitution of innate immunity to Pseudomonas aeruginosa post-BMT
3) Reconstitution of adaptive immunity to gammaherpesvirus post-BMT
Grants
Present and Active
08/12-09/13 R56AI065543-06 (Moore, B., PI)
HSCT Induced Changes that Impair Lung Immunity
National Institutes of Health
Role: PI
$240,885 direct costs
5/08-4/13 RO1 “ Regulation of Tumor-Associated Macrophages Interactions by TGF-β”
National Institutes of Health
Venkat Keshamouni ,P.I.
Bethany B. Moore, Co-I, (3% effort)
$250,000 direct costs
8/08-9/13 RO1 HL091745 “Fibrocyte Phenotypes as biomarkers in IPF”
National Institutes of Health
Bethany B. Moore, PI (19% effort)
$225,000 direct costs NCE
4/10-3/14 R01 HL 097564 (Standiford)
Flagellin Stimulates Lung Innate Mucosal Immunity
National Institute of Health
Role: Co-Investigator (5% effort)
$290,442 direct costs
4/10-3/14 R01 HL102013 (Raghavendran)
Mechanisms of MCP-1 activity in lung contusion with and without gastric aspiration
National Institutes of Health
Role: Co-Investigator (5% effort) $271,265
$250,000direct costs
12/10-11/15 RO1 AI083334 NIH (Weinberg)
Modulation of Adenovirus Pathogenesis by Prostaglandin E2
Role: co-I (5% effort)
$277,227
1/12-11/13 R21 HL108196 “Mechanisms for Fibrocyte-Mediated Enhancement of Survival in Sepsis”
National Institutes of Health
Jean Nemzek (PI)
Role co-I (5% effort)
$125,000 direct costs
1/12-6/13 MICHR Pilot Grant, U of M internally funded
“Clinical and Biological Repository of Pulmonary
Complications post-Stem Cell Transplant”
Role: PI
$75,000 direct costs
ActiveTraining and Equipment Grants:
09/07-08/12 NIH-DHHS-US-07-3130 Lung Immunopathology Traning Grant
Nick Lukacs (PI)
Role: participating investigator with specified effort
$1,501, 812
04/10-03/11 NIH-DHHS-US-09-PAF0174 Incucyte: a live cell imaging system that fits in a standard CO2 incubator
Venkat Keshamouni (PI
Role: participating investigator with specified effort
$155,465
09/10-06/12 NIH DHHS-US-10-PAF05958 Alpha 3beta 1 integrin function in epithelial mesenchymal transition and fibrosis
Kevin Kim (PI)
Role: KO8 mentor
$248,858
Pending Grants
07/13-06/18 NIH HL115618 Periostin Regulation of Lung Fibrosis
Moore, BB (30% effort)
PI
$273,728 direct costs
SCORE: 5th percentile
3/14-2/19 University of Michigan Center for Excellence in Translational Research on Infectious Diseases
DiRita, V (overall PD)
Moore, B. (co-I, project 3 -5% effort)
Overall budget=1,247,964 directs; Project 3 =$219,964
Summary of Major Previous Grants
8/86-7/89 NIH Cancer Immunology Training Grant (CA09082)
3/94-6/94 Stanford Molecular and Cellular Immunobiology Training Grant (NIH#5T32AI-07290)
1994 NIH NRSA Post-doctoral fellowship award recipient (declined)
7/94-3/97 National Multiple Sclerosis Society Postdoctoral Fellowship award recipient (FA 1118-A-1)
6/97-7/98 National Multiple Sclerosis Society Research Grant
(RG 2957 A1/T)
"Characterization of Invariant Chain Gene Regulation"
P.I. Bethany Moore, 0% effort $7,229 direct costs
12/97-12/98 Michigan Diabetes Research and Training Center Pilot/Feasibility Grant (p60DK20572-21)
"CXC Chemokines Regulation in RPE Cells"
P.I. Bethany Moore, 0% effort $20,000 direct costs
12/98-3/01 RO1: "Retinal Cell-Leukocyte Binding Induces CXC/CC Chemokines"
National Institutes of Health
P .I. Victor Elner
Co-Investigator: Bethany Moore, 20% effort
$1,413,372 direct costs
12/97-11/01 NIH SCOR project 5 “Macrophage-Epithelial Cell Interactions in Fibrosis”
National Institutes of Health
P.I. Galen B. Toews
Co-Investigator: Bethany Moore, 10% effort
$863,000 direct costs
7/98-6/03 R29CA79046 "CXC Chemokine Regulation of Prostate Cancer Angiogenesis"
National Cancer Institute
P.I. Bethany Moore, 40% effort
$350,000 direct costs
12/00-11/03 NIH ALI SCOR "CCR2 Regulation of Fibrosis Following Acute Lung Injury" National Institutes of Health
P.I. Galen B. Toews
Co-P .I. Bethany B. Moore, 20% effort
$1,125,000 direct costs
7/99-6/04 HL63670 "Chemokine Receptors in Immunity to C. neoformans"
National Institutes of Health
P.I. Gary Huffnagle
Co-Investigator: Bethany Moore, 2.5% effort
$875,000 direct costs
8/00-7/05 R01 HL065912 "Modulation ofTh1/Th2 responses by innate immunity"
National Institutes of Health P.I.: Gary Huffnagle
Co-Investigator: Bethany Moore, 5% effort
$923,000 direct costs
4/01-3/06 RO1 AI49448 “Gamma Delta T Cells in Anti-Bacterial Host Defense”
National Institutes of Health
P.I. Thomas A. Moore
Co-investigator: Bethany Moore, 10% effort
$1,025,000 direct costs
12/01-11/06 NIH SCOR P50 HL56402 project 5 “Regulation of Fibrosis by Alveolar Cells Expressing CCR2”
National Institutes of Health
Toews, PD, P.I. Galen B. Toews
Co-Investigator: Bethany Moore, 12.5% effort
$863,000 direct costs
12/01-11/06 NIH SCOR P50 HL56402 project 2 “Eicosanoid Imbalance in Fibrotic Lung Disease”
National Institutes of Health
Toews, PD, P.I. Marc Peters-Golden
Co-Investigator: Bethany Moore, 5% effort
$917,905 direct costs
3/05-4/06 “The Role of Circulating Fibrocytes in the Pathogenesis of Pulmonary Fibrosis”
Coalition for Pulmonary Fibrosis
Bethany Moore and Galen Toews, co-P.I.s, 0% effort
$33,000 direct costs
7/02-6/07 RO1 CA094121 “Promotion of Angiogenesis in Lung Cancer by MIF”
National Institutes of Health/NCI
Douglas Arenberg, P.I.
Co-Investigator: Bethany Moore 5% effort
$1,000,000 direct costs
8/03-7/07 RO1 HL071586 “PGE2 Regulation of Epithelial/Fibroblast Interactions”
National Institutes of Health/NHLBI
Bethany Moore, P.I. 40% effort
$875,000 direct costs
6/06-7/07 Martin Edward Galvin Fund for Pulmonary Fibrosis Research
“Exploring the role of herpesvirus infections in the predisposition to or acute exacerbation of experimental pulmonary fibrosis”
Bethany B. Moore, P.I. 5% effort
$25,000 direct costs
7/05-6/08 Career Investigator Award “Recruitment and Activation of Lung Fibrocytes in Experimental Pulmonary Fibrosis”
American Lung Association of Michigan
Bethany B. Moore, P.I. 10% effort
$180,000 direct costs
7/07-6/08 Research Funding Agreement
“Gene Expression post-Fibrotic Challenge”
Centecor, Inc.
Bethany B. Moore, P.I., 1% effort
$9022 direct cost
12/07-11/08 Research Funding Agreement
“p19 and IL-17 in fibrosis”
Centecor, Inc.
Bethany B. Moore, P.I., 2% effort
$17,467 direct cost
1/08-12/08 Profibrotic Effects of Herpesvirus in Lung Cells
Pulmonary Fibrosis Foundation
Galen Toews (PI); Bethany Moore, (co-I 5% effort)
$100,000 direct cost
4/08-3/09 U. M. Center for Rare Disease
“Fibrocytes in the Pathogenesis of Fibrotic Lung Disease”
Bethany Moore (PI), no effort
$30,000 direct costs
9/09-9/10 Pfizer (B. Moore)
Biomarker Discovery in Fibrotic Lung Disease
Role: PI (1% effort)
$12,448 direct costs
8/08-1/12 Centecor, Inc. (B. Moore)
Enumeration of Circulating Fibrocytes in Subjects with Idiopathic Pulmonary Fibrosis Treated with a Novel Anti-Fibrotic Agent.
Role: PI (1% effort)
$27,000 direct costs
5/07-8/12 RO1 AI065543 “PGE2 Regulation of Host Defense post-BMT”
National Institutes of Health
Bethany Moore, P.I., 25% effort
$250,000 direct costs
5/09-8/12 Research Supplement to parent grant AI065543
$100, 103
10/08-8/12 University of Michigan Biology Support for Centecor’s CCL17 Program
Centecor Pharmaceutical Co.
Cory M. Hogaboam, (PI)
Bethany B. Moore, subcontract PI, (10% effort)
Subcontract direct costs $302,228
7/07-6/12 RO1 HL082818 “Regulation of Fibroblast Phenotype in Lung Fibrosis”
National Institutes of Health
James Hagood (P.I.), University of Alabama
Bethany B. Moore, co-I (5% effort) subcontract
$9049 direct costs
3/08-3/13 RO1 HL087846 “Herpesvirus infection/injury govern fibrocyte recruitment and activation”
National Institutes of Health
Galen B. Toews, PI
Bethany B. Moore, co-I (16% effort)
$250,000 direct costs
9/09-8/12 RC2 HL101740 (Martinez, Flaherty)
CTRIP: Molecular phenotypes of rapidly progressive idiopathic pulmonary fibrosis
National Institutes of Health
Role: Co-investigator (5% effort)
$3,411,051 direct costs
Honors and Awards
Institutional
1990 Sigma Xi Award Winner, Graduate Student Research Forum
1992 Dean's Discretionary Award
2010 Michigan “Making a Difference” Award
2011 Distinguished Alumnus, U.T. Southwestern Medical School, Immunology Graduate Program
Local
2005 Career Investigator Award, American Lung Association of Michigan
National
1997 Central Society for Clinical Research Young Investigator Award
Memberships in Professional Societies
National:
American Association of Immunologists, member 1998-present
American Thoracic Society, member 1998-present
Local:
Scientific Center Affiliations:
1999-2004 Member University of Michigan Diabetes Research and Training Center
2000-2004 Member University of Michigan Comprehensive Cancer Center
Graduate Study Program Affiliations:
2002-present Member Immunology Graduate Program Faculty
2005-present Preceptor for Lung Immunopathology Training Grant
T32 HL07517
2001-present Preceptor for Multidisciplinary Training Program in Lung Disease T32HL07749
2003-present Preceptor for Research Training in Experimental Immunology T32 AI007413
2005-present Member Graduate Student Affairs Committee for Immunology
2007-2010 Preceptor for ULAM Comparative Medicine Training Grant
2009-present Member Microbiology and Immunology Graduate Program
Editorial Positions, Boards and Peer-Review Service
Editorial Boards
2006-2008 American Journal of Physiology: Lung Cellular and Molecular Biology, Member Editorial Board
2006-2009 The Journal of Immunology, Associate Editor
2007-present Fibrogenesis and Tissue Repair, Member Editorial Board
2009-present The Journal of Immunology, Section Editor
2012 Guest editor, PLoS Pathogens
National Institutes of Health Study Sections:
2001 Member Special Study Section to review RFA HL-01-003 “Cardiovascular, Lung and Blood Immunobiology in Health and Disease”
2002 Member Mentored Scientist Special Emphasis Panel (KO8, K02, K23), National Heart, Lung, and Blood Institute Review Branch, February and June
2003 Member Mentored Scientist Special Emphasis Panel (KO8, KO2, K23), National Heart, Lung and Blood Institute Review Branch, March, November
2004 Member Mentored Scientist Special Emphasis Panel (KO8, KO2, K23), National Heart, Lung and Blood Institute Review Branch, March
2005 Member F32 Mentored Post-doctoral fellowship review panel, National Heart, Lung and Blood Institute Review Branch, March, Novemeber
2006 Member Mentored Scientist Special Emphasis Panel (F31/F32), National Heart, Lung and Blood Institute Review Branch, March
2007 Member Mentored Scientist Special Emphasis Panel (F31/F32), National Heart, Lung and Blood Institute Review Branch, March, July
2008 Member Mentored Scientist Special Emphasis Panel (F31/F32), National Heart, Lung and Blood Institute Review Branch, March, July
2008 Ad hoc reviewer, National Heart, Lung and Blood Institute Review Branch for Member Conflict Applications, September
2008 Member Small Business Respiratory Sciences Review Panel, National Institutes of Health, November
2009 Member, NIH-CSR-ZRG1 CVRS-10 B Small Business-Respiratory Sciences Review Panel, National Institutes of Health, July
2009. Member, NIH ZHL1 CSR-H (O2)-ARRA GO TRIP Review Panel, National Institutes of Health, July.
2009 Ad-hoc member, NIH NHLBI Lung Injury Remodeling and Repair (LIRR) study section, Bethesda, MD, October
2010. Ad-hoc member NIH NHLBI Program Project grant review, April
2011. Member, NIH-CSR Small Business-Respiratory Sciences Review Panel, National Institutes of Health, July
14. Permanent member NIH NLBI Lung Injury Remodeling and Repair (LIRR)
section, Bethesda, MD-4 year term till 2014 starting in October.
2012. Ad hoc member Mentored Scientist Special Emphasis Panel (F31/F32),
National Heart, Lung and Blood Institute Review Branch, mail reviewer, May
Other Scientific Study Sections
2002. Ad hoc reviewer for The Israel Science Foundation
2003. Ad hoc reviewer for the British Lung Foundation
2005 Ad hoc reviewer for the Wellcome Trust Foundation
2006 Ad hoc reviewer for the British Lung Foundation
2007 American Thoracic Society grant reviewer
2008 Ad hoc reviewer for the Medical Research Council (UK)
Journal Reviewer
1997-present Journal of Immunology
1998-present American Journal of Pathology
1998-present American Journal of Physiology: Lung Cellular and Molecular Physiology
2000-present Journal of Clinical Investigation
2002-present American Journal of Respiratory and Critical Care Medicine
2002-present American Journal of Respiratory Cell Molecular Biology
2004 Expert Opinion on Pharmacotherapy
2005-present Bio Med Central Cell Biology
2006 Journal of the Association for Research in Otolaryngology
2006-present Pulmonary Pharmacology and Therapeutics
2007-present Journal of Clinical Immunology
2011 Pediatric Blood and Cancer, PLOS one
Teaching
Previous:
1995-1996 California State University at Hayward--Spring quarter, taught BIO 3405 (Microbiology laboratory);
Summer quarter, taught BIO 4430 (Immunology).
Taught BIO 4430 again, Summer 1996
1996 Stanford University--Summer quarter, Taught BIO 131 (Immunology)
Mentoring at Stanford University:
Research mentor for Sarah Conley, undergraduate student who went on to attend medical school at Brown University.
Current position, Urologist, Cleveland Clinic
University of Michigan Teaching:
Graduate Courses:
2000 November, Fibrosis lecture for Immunology 850
2002 November, Chemokine Lecture for Immunology 850
2003 October, Apoptosis lecture for Immunology 850
2004 Course director, Immunology 850
2005-2007 Discussion facilitator, PIBS 503
2006-2009 Course director, Immunology 851, Graduate level Special Topics in Immunology offered Fall of each year
2010-Panel member for Pharmacology 502, a class on grant writing
2010-Immunology 851 lecture on Influenza
2011-Immunology 851 lecture on Influenza and Bacterial superinfections
2012-Immunology 851 lecture on Influenza and Bacterial superinfections
Undergraduate Courses:
2005-present Course director for Microbiology 415, Virology. This is an undergraduate course offered by the medical school with approximately 30 1 ½ hour sessions. I designed this course and give the majority of the lectures. Enrollment has grown in each year it has been offered (currently ~65 students). It is offered in the Winter semester of each year. Teaching evaluations available upon request.
Mentoring for MD Pulmonary Fellows:
2000-2003 Research Mentor for Dr. Charles Ojielo
Current position: Assistant Professor, Cook County Hospital, Chicago, IL
2000-2002 Research Mentor for Dr. Vibha Lama
Current position: Assoc. Professor, University of Michigan Dept. of Internal Medicine
2002. Research Co-Mentor for Dr. Ryan Charbanneau
Current position: Private practice
2005-2008 Research Mentor for Dr. Tracy McMillan
Current position: Asst. Professor, University of Alabama at Birmingham
2008. Research Mentor for Dr. Kristy Phillips (Bauman)
Current position: Clinical Assistant Professor, University of Michigan
2008-2010 Research Mentor for Dr. Brian Bauman
Current position: Clinical Researcher, Private hospital, Akron Ohio
2010-1011 Research Mentor for Dr. Paul Bozyk
Current position: Assistant Professor and Director of medical education, Beaumont Hospital, Royal Oak, MI
2009-2012 Research Mentor for Dr. Payal Naik
Current position: Clinical instructor, University of Michigan
2011- present Research Mentor for Dr. Hillary Loomis-King
Committee Service for Pulmonary Fellows:
2005-present Coordinator for Creating Research Mentoring Committees for all Pulmonary Fellows
2005-2006 Member Research Mentoring Committee for Dr. Marc McClelland
2005-2006 Member Research Mentoring Committee for Dr. Dan Keena
2005-2007, Research mentoring committee for Dr. Michael Mendez
2006-2009, Research mentoring committee for Dr. Monica Smith
2005-2008, Research mentoring committee for Dr. Steven Huang
2005-2007, Research mentoring committee for Dr. Urvashi Bhan
2009-2011, Research mentoring committee for Dr. Paul Bozyk
2012-present, Research mentoring committee for Dr. Jake Scott
Mentoring for Ph.D. Post-doctoral Fellows:
2002-2004 Research Mentor for Dr. Jill Kolodsick
Current position: Teaching Faculty, Community College; Textbook editor
2007. Research Mentor for Dr. Megan Ballinger
Current position: Post-doctoral fellow, University of Michigan
2010-2012, Research mentoring committee for Dr. Megan Ballinger
2010-present: Advisory committee for Emily Rainey-Barger
Current position: Post-doctoral fellow, University of Michigan
2010-11: Research mentor for Kevin Vannella
Current position: Post-doctoral fellow, NIH
Mentoring for Ph.D. Students
2003-2006 Dissertation Advisor for Ph.D. student Megan Ballinger
2006-2010 Dissertation Advisor for Ph.D. student Kevin Vannella
2006-2011 Dissertation Advisor for Ph.D. student Leah Hubbard
2008-2011 Dissertation Advisor for Ph.D. student Stephanie Coomes
2011-present Dissertation Advisor for Ph.D. student Racquel Domingo-Gonzalez
2012-present Dissertation Advisor for Ph.D. student Shanna Ashley
Mentoring for Junior Faculty Members
2008-2010 K08 award mentor to Dr. Tracy (McMillan) Luckhardt
2010-present KO8 mentor for Dr. Kevin Kim
2010-present Mentor for Dr. Paul Bozyk
2008-present, Mentor for Jean Nemzek, DVM in support of her transition from a KO8 to an RO1 after her primary mentor left the University
2011-2012 Mentor for Dr. Yang-Jin Jegal, a visiting professor from South Korea
Preliminary Examination Committees:
Member Immunology Prelim Committee 2 year term, 2004-2005
Member Prelim Exam Committee for Eric Komuniecki, 2004
Head, Byrna Burrell Prelim Exam Committee, March 2005
Member Prelim Exam Committee for Tiffany Tsang, 2005
Member Prelim Exam Committee for Brian Gray, 2006
Member Prelim Exam Committee for Thom Todd, 2009
Member Prelim Exam Committee for Chun-Shu Wong, 2011
Member Prelim Exam Committee for Juliana Cunha, 2012
Member Prelim Exam Committee for Brittan Scales, 2012
Member Prelim Exam Committee for Mary McCarthy, 2012
Member Prelim Exam Committee for 3 Microbiology students (Checkpoint 1), 2012
Dissertation Examination Committees:
Member of Jennifer Fuller’s dissertation committee, Immunology graduate program, defense date Oct. 3, 2005 “Selectin ligands regulate myelopoiesis and contribute to HSC homing and engraftment”
Member Haitoao Wen dissertation committee, Pathology graduate program, 2005-2007, defense date Aug., 29, 2007 “Long term effects of severe sepsis on dendritic cell function”
Member of Shika Aurora’s dissertation committee, Immunology graduate program, 2004-2006, defense date Feb. 20, 2006 “Role of IL-4 and IFNgamma in regulating macrophage differentiation during murine allergic bronchopulmonary mycosis”
Member of Tim Hale’s dissertation committee, Public Health graduate program, 2004-2006 (dismissed, June 30, 2006)
Chairperson, Megan Ballinger’s dissertation committee, Immunology graduate program, 2004-Dec. 2006, Defense 12/15/06 “Cytokine and eicosanoid regulation of pulmonary host defense post bone marrow transplant”
Member of Betsy Pierce’s dissertation committee, Immunology graduate program, 2004-Dec. 2006, defense date 12/1/06 “The role of CCR7 in idiopathic interstitial pneumonia”
Member Byrna Burrell dissertation committee, Immunology graduate program, 2005-2007, defense date Dec.3, 2007 “The CD40:CD40L costimulation pathway in transplantation”
Member Tiffany Tsang dissertation committee, Microbiology and Immunology graduate program, 2006- 2008 (Switched laboratories and formed new committee, Feb. 15, 2008)
Chairperson, Kevin Vannella’s dissertation committee, Immunology graduate program, 2006 to 2009, defense date April 16, 2009.”Herpesvirus infection augments the response to subsequent fibrotic challenge in the lung via the recruitment of fibrocytes and the induction of pro-fibrotic factors”
Member, Adam Booth dissertation committee, Immunology graduate program, 2007-2009, defense date, March 30, 2009. “Role of IL-6 and CTGF in heart allograft rejection”
Member, Susan Faust dissertation committee, Immunology graduate program, 2007-2009, defense date August 17, 2009. “Transforming growth factor beta, allograft acceptance and chronic allograft rejection”
Member, Adam Hartigan dissertation committee, Immunology graduate program, 2007-2009, defense date June 3, 2009.”The role of CC chemokine receptor 7 during pulmonary invasive aspergillosis”
Member, Hemanth Ramaprakash dissertation committee, Immunology graduate program, 2008-2010, Defense date April 12, 2010. “ST2L negatively regulates therapeutic TLR9 ativation in asthma”
Chairperson, Leah Hubbard dissertation committee, Immunology graduate program, 2007-2011 Defense date, March 18, 2011. “IRAK-M and PTEN regulation of innate immunity post-bone marrow transplantation”
Member, Cailin Wilke dissertation committee, Immunology graduate program, 2008-2010. Defense date December 10, 2010. “IL-10 in tumorigenesis and inflammatory bowel disease”
Chairperson, Stephanie Coomes dissertation committee, Immunology graduate program, 2008-2011. Defense date: June 10, 2011. “Transforming growth factor beta in gammaherpesvirus infection and pneumonitis post-bone marrow transplantation.
Member, Mary J. Wilson dissertation committee, Microbiology and Immunology graduate program, 2008-2012. Defense date: 8/7/12. “Characterization of germinant receptor membrane topology in Bacillus.”
Member, Stephanie Linn dissertation committee, Cell and Molecular Biology graduate program, 2009-2012. Student was dismissed with a Master’s degree on August 27, 2012.
Member, Rachel Morgan dissertation committee, Immunology graduate program, 2009-present
Member, Tien-Huei Hsu dissertation committee, Microbiology and Immunology graduate program, 2009-2012. Defense date August 9, 2012. “Contribution of a major quantitative trait locus to encephalitis caused by murine adenovirus”.
Member, Mariam Gonzalez-Hernandez dissertation committee, Immunology graduate program, 2010-present.
Member, Anuli Anyanwu dissertation committee, Molecular and Integrative Physiology, 2010-present.
Member, Jose, A. Rodriquez-Nieves dissertation committee, Cell Molecular Biology graduate program, 2011-present
Member, Brittan Scales dissertation committee, Microbiology and Immunology graduate program, 2012-present
Member, Mary McCarthy dissertation committee, Microbiology and Immunology graduate program, 2012-present
Chairperson, Racquel Domingo-Gonzalez dissertation committee, Immunology graduate program, 2011- present
Member, Michelle Reed dissertation committee, Immunology graduate program, 2012-present
Member, Jun Young-Hong dissertation committee, Molecular and Integrative Physiology Program, 2012-present
Member, Victoria Holden dissertation committee, Microbiology and Immunology graduate program, 2013-present
Member, Hayley Warsinske dissertation committee, Microbiology and Immunology graduate program, 2013-present
Ph.D. Student Rotations:
2001. March-June, Research rotation for Megan Ballinger, Immunology program
2005 Sept-Dec, Research rotation for Esther Choi, Immunology program
2006 Jan-Mar Research rotation for Deepti Nagarkar, Physiology program
2007 May-June Research rotation for Leah Hubbard, Immunology program
2006. May-June Research rotation for Stephanie Coomes, Immunology program
2010 September-December research rotation for Michelle Reed, Immunology program
2011 January-February research rotation for Carly Smith, Immunology program
2011 April-June research rotation for Raquel Domingo-Gonzalez, Immunology program
2011 September-December, research rotation for Shanna Ashley, Immunology program
Mentoring of Research Staff:
1999-2001 Mentor for Stephanie Sitterding, a research associate in my laboratory during her Master’s Thesis Work.
Current position: Resident, University of Illinois at Chicago
2001-2003 Mentor for Cara J. Chrisman, a research associate in my laboratory Current position: Graduate Student in the PhD program in Microbiology at Albert Einstein University.
2003-2006 Mentor for Amy Herrygers, B.A. from Michigan State University
Current position: Research associate at Vanderbilt University then University of Michigan
2008-2010 Mentor for Josh Stoolman, B.A. from Kalamazoo College
Current position: Graduate student in PIBS, University of Michigan
Mentoring for Undergraduate Students:
1997-1998 Kevin Stoy and Tamara Morgan in Undergraduate Research Opportunities Program
Current positions: Kevin Stoy: Graduate Student University of Michigan LSA; Tamara Morgan: Electrical engineer
1998-1999 Kevin Stoy and Rose Ngan in Undergraduate Research Opportunities Program
Current positions: Kevin Stoy: Graduate Student University of Michigan LSA;
Rose Ngan: Resident, University of Washington
1999-2000 Rose Ngan and Linsdey Pych in Undergraduate Research Opportunities Program
Current positions: Rose Ngan: Residentt, University of Washington; Lindsey Pych, research fellow, National Institutes of Health
2004 Alexa Lindley, Undergraduate summer research student
2005 Alexa Lindley and Anna Stroud, Undergraduate summer research students
2006 Amber Moore, Undergraduate summer research
2007 Marnie Hyzy, Undergraduate summer research
2008 Jeffrey Gibson, Undergraduate research associate (1/08-6/08) Current position: medical student at Wayne State University.
2009 Faculty sponsor for University of Michigan chapter of “Innoworks” a student-run program to provide week-long summer research opportunities for local middle school youth.
2010 Stefanie Gibson, undergraduate summer research student
2011 Laura Leach, undergraduate research student
2011 Katie Higdon, research assistant between graduation from Cornell and starting medical school (till 2012)
2011 Carolyn Birch, U of M undergraduate
2012 Samuel Katz, SUNY Downstate undergraduate student, SURP summer program
2013 Alana Smith, Florida A&M undergraduate student, SURP summer program
2013 Omar Sanyurah, Univ. Miami Ohio, undergraduate student, MD, PhD summer PREP program
Honors Thesis Committees for Undergraduates
2008 Reader for William Shield’s honor’s thesis (Advisor: David Miller)
2008 Reader for Jingga Inlora’s honor’s thesis (Advisor: Akira Ono)
2011 Reader for David Chapel’s honor’s thesis (Advisor: Christiana Wobus)
2011 Reader for Stuart Zelter’s honor’s thesis (Advisor: Michal Olsziewski)
2013. Reader for Alex Myong honor’s thesis (Advisor: Akira Ono)
2013-present, Ellen Katcha, honor’s thesis research advisor
2013 Reader for Eunie Kim honor’s thesis (Advisor: Jason Weinberg)
Mentoring for High School Students:
Summer 2001 Rebecca Nutting and Lindsey Richards, Huron High School Summer Research Project
Current positions: Rebecca Nutting and Lindsy Richards are both graduates of Eastern Michigan University
2001 Mentor for HOPE program (Health Occupations Partners in Education)
2007 Guest lecturer Troy High School “The immune system; the best offense is a good defense”, April 30, 2007
Miscellaneous Teaching:
1997 September, Pulmonary Research Conference
October, Mentor for Pulmonary Fellow's Journal Club Seminar with Dr. Tom Sisson
1998 June, Mentor for Pulmonary Fellow's Works-in-Progress Seminar with Dr. Wan Tsai,
November, mentor for Dr. Tom Sisson's Journal Club,
December, Lectured Pulmonary Fellows on Mechanisms of Gene Regulation.
1999 Mentor for Dr. Amy Herring's Journal Club presentation
2000 September, Lecture for Pulmonary fellows on Molecular Biology Research Applications
2002 Mentor for Dr. Jill Kolodsick’s Journal Club presentation
2003 Mentor for Dr. Mike Lazaar’s Journal Club presentation
2003 August, Molecular Biology general lectures for Pulmonary Fellows
2004 Mentor for Dr. Michael Mendez Journal Club presentation
2004 June, Pulmonary Research Conference “CCR2, Master switch for pulmonary fibrosis?”
2005 Mentor for Dr. Marc McClelland journal club
2005 September, Pulmonary Research Conference, Herpesvirus, fibrocytes and fibrosis-What’s the link?
2007 Post-graduate course 10, American Thoracic Society International Meeting titled “Grant Fundamentals” My session title “Funding Strategies for Aspiring Investigators”, May 18, 2007, San Francisco, CA.
2009 Evaluator for M.J. Wilson Microbiology 812 seminar
2010 Post-graduate course 10, American Thoracic Society International Meeting titled “Grant Fundamentals” My session title “Funding Strategies for Aspiring Investigators”, May 18, 2010, New Orleans, LA.
2010 Evaluator for Tien-Huei Hsu and Lucy McNamara Microbiology 812 seminars.
2010 Evaluator for Shelly Leung, Immunology 815
2013 Evaluator for Michelle Reed, Immunology 815
Committee, Organizational and Volunteer Service
Institutional:
U.T. Southwestern Graduate Student Organization
Secretary 1988-1989
Treasurer 1989-1990
President 1990-1991
University of Michigan
Distinguished Faculty Achievement Awards Selection Committee (2006- 2008)
Participant in the 2-day workshop with Friends and Allies of STRIDE Toward Equity in Recruiting (FASTER), May, 2008
Faculty Mentor for the Office of New Student Programs, 2009-2010.
faculty advisor for a group of 8 new freshman and one senior peer advisor; our group meets monthly during fall semester
Elizabeth Crosby Award Review Committee (2011)
STRIDE committee (2012-2017)
University of Michigan Medical School:
University of Michigan Advisory Committee on Primary Research Appointments, Promotions, and Titles (APRAPT), 2-year term (9/2001-8/2003)
Immunology Graduate Program Prelim Advisory Committee (2003-2005)
Immunology Graduate Program Graduate Affairs Committee (2005-present)
Biomedical Research Council (BMRC) (2006-2010)
Member, 2006-2007
Vice-Chair BMRC 2007-2008
Chair, BMRC-2008-2009
Past chair and member, 2009-2010-term extended to oversee the grant preview process started during my tenure as chair.
University Committee on the Use and Care of Animals, UCUCA (2007-2009)
Chair, UCUCA 2009-2010
Ad hoc reviewer 2011
Department of Microbiology and Immunology Prelim Committee (2009-2010; 2011)
ULAM Oversight Advisory Committee (2009)
Member, China-UM Lung Task Force (2009)
Advisory Board to the Advance Program in the Medical School (2009-present)
Member, North Campus Research Complex Program Review Committee (2010)
ULAM Review Committee (2010-2011)
Internal Medicine Nepotism Review Panel (2011-present)
University of Michigan Mentoring Committee (2011-present)
Planning champion “Experimental Immunotherapeutics” University of Michigan Medical School Fast Forward Initiative (2012-present)
Training faculty, Immunology Graduate Program (2003-present)
Training faculty, Microbiology and Immunology Graduate Program (2011-present)
Training faculty, Cell and Molecular Biology Graduate Program (2013-present)
National:
American Thoracic Society
Member, Allergy, Immunology and Inflammation (AII) Assembly 1999-present
Secondary Member, Respiratory Cell and Molecular Biology Assembly, 1999-present
Member, Allergy, Immunology and Inflammation Assembly Membership Committee, 1999-2001.
Chairperson, AII Membership Committee 2002-2004
Member, AII Long Range Planning Committee, 2000-present
Chairperson, AII Long Range Planning Committee, 2004-2006
Web Director, AII Assembly, 2006-2008
Member, AII committee to “Define a consensus definition of acute lung injury in animal models”, 2006-2008
Member, AII program committee, 2008-2011
AII Mentor and Liason for junior members, 2010-2012
AII Program committee chair-elect 2010-2011
AII Program committee chair 2011-2012
Consulting Positions
2005 Consultant for Centocor Pharmaceutical Company (USA)
2005 Consultant for the Frankel Group (USA)
2005 Consultant for Cryptopharma (Australia)
2005 Consultant for Otsuka Pharmaceuticals (Japan)
2013 Consultant for Takeda Pharmaceuticals.
Visiting Professorships, Seminars, and Extramural Invited Presentations
Extramural invited presentations
FASEB Meeting 1998, San Francisco, CA. CXC Chemokine Regulation of Prostate Cancer Angiogenesis.
Parke-Davis Toxicology Seminar Series, Ann Arbor, MI, June 17, 1998. Prostate Cancer Cell Lines Utilize Distinct CXC Chemokines to Regulate Tumorigenicity.
ALA/ATS International Conference, Apri125, 1999, San Diego, CA. T Cells Regulate Bleomycin- induced Pulmonary Fibrosis
European Haemotologic Society Conference on Angiogenesis and Tumours, October 22, 1999, Paris, France: Chemokines and Angiogenesis
Aspen Lung Conference, May 30-June 4, 2000, Aspen, CO. MCP-l and CCR2 Regulate FITC-lnduced Pulmonary Fibrosis.
Visiting Professor, University of Virginia School of Medicine, August 7-8, 2001., Charlottesville, VA, Cytokines, Chemokines, and Eicosanoids as Regulators of Pulmonary Fibrosis.
Visiting Professor, Lovelace Respiratory Research Institute, April 1, 2002., Albuquerque, NM, Eicosanoids and Epithelial Cells; Regulators of Pulmonary Fibrosis.
Visiting Professor, Department of Pathology, University of New Mexico, April 2, 2002, Albuquerque, NM, MCP-1 vs. PGE2. The Battle of Good and Bad in Pulmonary Fibrosis.
Visiting Professor, Department of Internal Medicine, Ohio State University, April 24, 2002, Columbus, OH, MCP-1 vs. PGE2. The Battle of Good and Bad in Pulmonary Fibrosis.
ATS 2002 International Conference, May 19, 2002, Atlanta, GA, Mice Deficient in IL-13 but not IL-4 are Protected from FITC-Induced Pulmonary Fibrosis.
ATS 2002 International Conference, May 22, 2002, Atlanta, GA, Pro-Fibrotic Actions of MCP-1: Inhibition of PGE2 Synthesis in Lung Macrophages and Alveolar Epithelial Cells.
Visiting Professor, National Institute of Environmental Health Sciences, October 16, 2002, Durham, NC, MCP-1 regulation of eicosanoid synthesis and cellular interactions in pulmonary fibrosis.
12th International Colloquium on Lung Fibrosis , Oct 9, 2002, Glion, Switzerland, Inhibition of Transforming Growth Factor-Β-Induced Myofibroblast Differentiation by Prostaglandin E2.
Visiting Professor, University of Illinois at Chicago, October 11-12, 2004, Chicago, IL. ,PGE2 Regulation of Pulmonary Host Defense Following Bone Marrow Transplantation.
13th International Colloquium on Lung Fibrosis, Oct. 20, 2004, Banff, Alberta, Canada, CCR2-mediated recruitment of fibrocytes to the alveolar space following fibrotic injury and their differentiation into effector fibroblasts.
Visiting Scientist, Centecor Pharmaceutical Co., July 7-8, 2005, Philadelphia, PA, The role of CCR2 as a master regulator for pulmonary fibrosis.
Visiting Professor, University of Alabama at Birmingham, Oct 23-25, 2005. Birmingham, AL. Recruitment and Regulation of Fibrocytes in Fibrosis.
Visiting Professor, Wayne State University, Dec 6, 2005. Detroit, MI, CCR2 as a master regulator of pulmonary fibrosis.
Visiting Professor, University of Geissen Molecular Biology and Medicine of the Lung Program, Geissen, Germany, Aug 2, 2006. Recruitment and Activation of Fibrocytes in FITC-Induced Fibrosis.
Invited Speaker, International Colloquium on Lung Fibrosis, “The role of TLR9 in mediating herpesvirus-induced exacerbations of lung fibrosis”, Mainz, Germany, Sept 7, 2006.
Invited Speaker, Winter Eicosanoid Symposium, “The role of eicosanoids in host-defense post-BMT”, Baltimore, MD, March 13, 2007
Invited Speaker, ATS PG-10 Grant Fundamentals post-graduate course. “Funding strategies for aspiring investigators”, May 17, 2007
Invited Speaker, Vermont Stem Cell Conference “Circulating Fibrocytes in the Pathogenesis of Lung Fibrosis”, July 31, 2007.
Invited Speaker, ATS International Conference “ Bone marrow-derived cells and pulmonary fibrosis”, May 20, 2007
Invited Speaker, ATS Scientific Symposium, “Regulation of Fibroblast Proliferation and Myofibroblast Differentiation by Prostaglandin E2”, Toronto, Canada, May 21, 2008.
Visiting Professor and Keynote Speaker, INBRE "Infrastructure Network for
Biomedical Research Enhancement”, an undergraduate research opportunity program in Nebraska. Grand Island, NE, “Regulation of Lung Immunity post-Bone Marrow Transplantation”, Aug 12-13, 2008.
Visiting Professor, University of Southern California “The role of herpesvirus in the pathogenesis of pulmonary fibrosis”, May 22, 2009.
Invited speaker, Pfizer Pharmaceutical Corporation, St. Louis, MO. “Fibrocytes as Effectors in Pulmonary Fibrosis, August 4, 2009.
Invited Speaker, Association of Specialty Professors “Workshop on Idiopathic Pulmonary Fibrosis in Older Adults”, my presentation “Progenitor cells in IPF: Bone marrow and stem cells”, Washington, DC, August 27-28, 2009
Visiting Professor, Vanderbilt University Medical School, November 30, 2009. Herpesviruses as co-factors for fibrotic lung disease.
Visiting Professor, Cleveland Clinic and Case Western Reserve University, April 28, 2010. Fibrocytes as mediators of fibrotic lung disease.
Invited Speaker, ATS PG Grant Fundamentals post-graduate course. “Funding strategies for aspiring investigators”, New Orleans, LA, May 15, 2010.
Invited speaker, International Colloquium on Lung and Airway Fibrosis “Chemokines in Fibrosis: What’s the attraction?”Busselton, Australia, Oct. 31, 2010.
Visiting Professor, Feinberg School of Medicine, Northwestern University, February 14, 2011.
Invited speaker, American Society of Blood and Marrow Transplantation (ASBMT) International Meeting. “TGFbeta, inflammation and fibrosis: their role after transplantation”, Honolulu, Hawaii Feb. 18, 2011.
Visiting Professor, University of Toledo “Immune Reconstitution Post Bone Marrow Transplantation”, Toledo, OH April 1, 2011.
Visiting Professor, University of Rochester Medical School. Featured speaker at Lung Biology Research Retreat “Herpesviruses, Aging and matricellular proteins in the pathogenesis of lung fibrosis”, Rochester, NY Oct. 29-30, 2012.
Invited Speaker, International Colloquium on Lung and Airway Fibrosis. “The role of aging and periostin in the regulation of lung fibrosis”, Modena, Italy, October 3, 2012.
Visiting Professor, University of California at Los Angeles, “Herpesviruses, Aging and matricellular proteins in the pathogenesis of lung fibrosis”, Los Angeles, CA, Jan 8-9, 2013.
Other Presentations
University of Michigan Comprehensive Cancer Center Fall Research Symposium. September 25, 1998. Prostate Cancer Cell Lines Utilize Distinct CXC Chemokines to Mediate Tumorigenicity.
Discussion Facilitator, C48-lmmune Mediators and Modulators, 1999 ALA/ATS International Conference, San Diego, CA April 27, 1999
Chairperson, Therapeutic Angiogenesis, European Haemotolgoic Society Conference on Angiogenesis and Tumors, Paris, France, October 25, 1999.
Facilitator, C44-Mechanisms of Pulmonary Fibrosis, 2002 ATS International Conference, Atlanta, GA, May 21, 2002
Facilitator, D102-IPF: Biological Mechanisms of Disease, 2003 ATS International Conference, Seattle, WA, May 21, 2003
Organizer, Allergy, Immunology, and Inflammation Membership Dinner and Lecture at the 2003 ATS International Conference, Seattle, WA, May 19, 2003
Organizer, Allergy, Immunology, and Inflammation Membership Dinner and Lecture at the 2004 ATS International Conference, Orlando, FL, May 23, 2004
Facilitator, Poster Discussion Session, Stem Cells in the Lung, ATS International Conference, San Diego, CA, May 25, 2006
University of Michigan Department of Urology Research Conference, Ann Arbor, MI, “ Role of CCR2 in regulating lung fibrosis”, August 11, 2006
Chairperson, International Colloquium on Lung Fibrosis, Mainz, Germany, Sept 7, 2006.
Invited Speaker, ULAM Faculty and Resident Seminar Series, “Animal modeling of lung fibrosis and exacerbations”, Nov. 21, 2006.
Facilitator, B69-Infectious Mechanisms in Inflammation and Injury, Thematic poster session, ATS International Conference, San Francisco, CA, May 21, 2007.
Invited Speaker, ATS International Conference Symposium D2 titled “IPF: Unraveling the Pathobiology, Formulating New Treatments. My seminar title “The Bone Marrow and Fibrosis”, San Francisco, CA, May 23, 2007.
Invited Speaker, Vermont Stem Cell Conference “ Stem cells and cellular therapies in lung biology and lung diseases, University of Vermont, Burlington, VT, July 31, 2007.
Invited Speaker, ATS Post-Graduate Course “Careertalk: the course”. My workshoop is entitled “PhDs Navigating an MD World”. Toronto, Canada, May 16, 2008.
Invited Speaker, “Regulation of Innate Immunity post-BMT” Invited speaker Microbiology and Immunology Departmental Faculty Seminar, June 19, 2008
Invited Speaker “Reconstitution of Lung Immunity following Bone Marrow Transplantation” Seminar for Immunopathology of Pulmonary DiseaseT32 Training Series. July, 21, 2008
Invited Speaker “Regulation of lung immunity post-bone marrow transplantation” Unit for Laboratory Medicine Resident Seminar Series, Sept. 4, 2008.
Invited Speaker, Nephrology Basic Science Research Conference “Regulation of immune function post-BMT”, October 21, 2008.
Facilitator, Thematic Poster Session entitled Pulmonary Fibrosis: Animal Models (B59) American Thoracic Society International Conference, San Diego, CA, May 18, 2009
Facilitator, Poster Discussion Session entitled “Viral Pathogenesis and Immunity” American Thoracic Society International Conference, San Diego, CA, May 19, 2009
Invited Speaker University of Michigan Pulmonary Rehabilitation IPF Support Group. “What’s new in IPF research”, Ann Arbor, MI, January 10, 2010.
Facilitator, Thematic Poster Session entitled “Pathobiology of Diffuse Interstitial Lung Disease”, New Orleans, LA, May 17, 2010.
Invited Speaker, First Annual Fibrosis Symposium sponsored by NIDDK and the Department of Urology, University of Michigan; “The Matricellular Protein Periostin as a Regulator of Lung Fibrosis”, Ann Arbor, MI Oct. 14, 2011.
Pulmonary Research Conference “Mechanisms of Impaired Alveolar Macrophage Function Post-Bone Marrow Transplantation”, September 26, 2012.
Microbiology Research Seminar “Regulation of adaptive immunity post-bone marrow transplant”, October 11, 2012.
ULAM Research conference “Mechanisms of Impaired Alveolar Macrophage Function Post-Bone Marrow Transplantation”, October 18, 2012.
Bibliography
Peer-Reviewed Journals and Publications
1. Yuan D, Wilder J, Moore BB, Dang T. Mechanism of LPS mediated enhancement of the μ gene. J Immunol. 1992; 148:3652-3657.
2. Moore BB, Ariizumi K, Tucker P, Yuan D. Transcriptional analysis of the inhibition of the LPS response by anti-μ. J Immunol. 1993; 150:3366-3374.
3. Moore BB, Tan,J, Lim, PL, Tucker, PW, Yuan, D. Regulatory elements necessary for the termination of transcription within the immunoglobulin heavy chain locus. Nuc Acids Res 1993; 21:1481-1498.
4. Moore BB, Meek KD. Recombination potential of the human DIR elements. J Immuno11995; 154:2175- 2185.
5. Wiler R, Leber R, Moore BB, Van Dyk L, Perryman L, Meek KD. Equine scid: A defect in V(D)J recombination and double strand break repair. Proc Natl Acad Sci USA 1996; 92:11485-9.
6. Van Dyk LF, Wise TW, Moore BB, Meek K. Immunoglobulin D H RSS targeting: Effect of DH coding and flanking regions and recombination partner. J Immuno1, 1996; 157:4005-15.
7. Moore, BB, Arenberg DA, Strieter RM. The role of CXC chemokines in the regulation of angiogenesis in association with lung cancer. Trends in Cardiovascular Med.1998; 2:51-58.
8. Moore, BB, Keane, MP , Addison, CA, Arenberg, DA, and Strieter, RM. CXC Chemokine Modulation of Angiogenesis: The Importance of Balance Between Angiogenic and Angiostatic Members of the Family. 1998. J. Invest. Med. 46(4):113-20.
9. Keane, MP, Arenberg, DA, Moore, BB, Addison, CA, and Strieter, RM. CXC chemokines and Angiogenesis/Angiostasis. The Proceedings of the Association of American Physicians 1998;110(4):288- 96.
10. Moore, BB, Arenberg, DA, Addison, CA, Keane, MP, Polverini, PJ, and Strieter, RM. CXC Chemokines Regulate Tumor Angiogenesis. Angiogenesis 1998;2(2): 123-134.
11. Moore, BB, Arenberg, DA, Addison, CL, Keane, MP , and Strieter, RM. Tumor Angiogenesis is Regulated by CXC Chemokines. J. Lab. Clin. Med. 1998, 132:97-103.
12. Moore, BB, Cao, ZA, McRae, TL, Woo, CH, Conley, S, and Jones, PP. The Invariant Chain Gene Intronic Enhancer shows homology to Class II Promoter Elements. 1998. J. Immunol. 161:1844-1852.
13. Keane, MP, Belpario, JA, Moore, TA, Moore, BB, Arenberg, DA, Smith, RE, Burdick, MD, Kunkel SL, and Strieter, RM. Neutralization of the CXC chemokine, macrophage inflammatory protein-2 (MIP 2), attenuates pulmonary fibrosis via inhibition of angiogenesis. 1999. J. Immunol. 162:5511-5518.
14. Moore, BB, Arenberg, DA, Stoy, K, Morgan, T, Addison, CA, Morris, SB, Glass, M, Wilke, C, Xue, YY, Sitterding, S, Kunkel, SL, Burdick, M, and Streiter, RM. Distinct CXC Chemokines Mediate Tumorigenicity of Prostate Cancer Cells. 1999. Am. J. Pathol. 155:1503-1512.
15. Christensen, PJ, Goodman, RE, Pastoriza, L, Moore, BB, and Toews, GB. Induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T -cell dependent. 1999. Am. J . Pathol. 155: 1773-1779.
16. Moore, T A, Moore, BB, Newstead, MW , and Standiford, TJ. Gamma delta T cells are critical for survival and early pro-inflammatory cytokine gene expression during murine Kebsiella pneumonia. 2000, J. Immunol. 165:2643-2650.
17. Moore, BB, Coffey, M, Christensen, P, Sitterding, S, Ngan, R, McDonald, R, Phare, S, Peters-Golden, M, Paine, R and Toews, GB. GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis via a Prostaglandin E2 Mechanism. 2000, J. Immunol. 165:4032-4039.
18. Cao, ZA, Moore, BB, Quezada D, Chang, C-H and Jones, P. Identification of an IFN-γ responsive region in an intron of the invariant chain gene. 2000. Eur. J. Immunol. 30:2604-2611.
19. Olszewski, M.A., GB Huffnagle, RA McDonald, DM Lindell, BB Moore, DN Cook, and GB Toews. The Role of :MIP-lα/CCL3 in Regulation of T Cell Mediated Immunity to Cryptococcus neofonnans Infection. 2000. J Immunol. 165:6429-6436.
20. Hattori, N., J.L. Degan, T.H. Sisson, H. Liu, B. B. Moore, R.G. Pandrangi, R. H. Simon, and A.F. Drew. Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice. 2000. J. Clin. Invest. 106:1341-1350.
21. BB Moore, PJ Christensen, C Wilke, S Sitterding, R Paine III, and GB Toews. 2001. Fluorescein Isothiocyanate-Induced Pulmonary Fibrosis is Regulated by Monocyte Chemoattractant Protein-1 and CC Chemokine Receptor 2. Chest 120 (1) 1S.
22. Moore, BB, R Paine, III, PJ Christensen, S Sitterding, TA Moore, R Ngan, CA Wilke, WA Kuziel, GB Toews. Protection from Pulmonary Fibrosis in the Absence of CCR2 Receptor Signaling. 2001. J. Immunol. 167:4368-4377.
23. Paine, R. III, Morris, S.B., Hong, J., Wilcoxen, S.E., Phare, S.M., Moore, B.B., Coffey, M.J., and G.B. Toews. Impaired Functional Activity of Alveolar Macrophages from GM-CSF-Deficient Mice. 2001.Am. J. Physiol. Lung Cell Mol Physiol. 281(5):L1210-18.
24. Peters-Golden,M, M. Baile, T Marshall, C Wilke, S Phan, GB Toews and BB Moore. Protection from Pulmonary Fibrosis in Leukotriene Deficient Mice. 2002. Am J. Resp. Crit. Care Med. 165:229-235.
25. Moore, BB, TA Moore, and GB Toews. Role of T and B Lymphocytes in Pulmonary Host Defences. 2001 Eur. Respiratory Journal. 18 (5): 846-56.
26 Lama, V, Moore, BB, Christensen, P, Toews, GB, and M Peters-Golden. 2002. Prostaglandin E2 Synthesis and Suppression of Fibroblast Proliferation by Alveolar Epithelial Cells is Cyclooxygenase-2 Dependent. Am J. Respir. Cell Mol Biol. 27:752-758.
27. Moore, BB, Peters-Golden, M, Christensen, PJ, Lama, V, Kuziel, WA, Paine, R, and GB Toews. Alveolar Epithelial Cell Inhibition of Fibroblast Proliferation is Regulated by MCP-1/CCR2 and Mediated by PGE2. 2003. Am. J. Physiol. Lung Cell Mol. Physiol. 284(2):L342-9.
28. Charbenneau R.P.., Christensen, P.J., Chrisman, C.J., Paine, R. III, Toews, G.B. Peters-Golden, M. and B.B. Moore. 2003 Impaired Synthesis of PGE2 by Lung Fibroblasts and Alveolar Epithelial Cells from GM-CSF -/- Mice: Implications for Fibroproliferation. Am. J. Physiol. Lung Cell Mol Physiol. 284:L1103-1111.
29. Kolodsick, J.E., Peters-Golden, M., Larios, J., Toews, G.B., Thannickal, V.J., and Moore, BB. 2003. Prostaglandin E2 Inhibits Fibroblast to Myofibroblast Transition via E Prostanoid receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation. Am J. Resp. Cell Mol. Biol. 29: 537-544.
30. Ojielo, CI, Cooke, KD., Mancuso, P., Standiford, TJ, Olkiewicz, KM, Cloutheir, S, Corrion, L, Ballinger, MN, Toews, GB, Paine, R and BB Moore. 2003, Defective Phagocytosis and Clearance of Pseudomonas aeruginosa in the Lung Following Bone Marrow Transplantation. J. Immunol. 171:4416-4424.
31. Christnesen,PJ, Du, M, Moore, BB, Morris, S.B., Toews, G.B. and Paine, R. 2004. Expression and Functional Implications of CCR2 Expression on Murine Alveolar Epithelial Cells. Am J Physiol Lung Cell Mol Physiol., 286:L68-72.
32. Kolodsick, JE, Toews, GB, Jakubzick, C, Hogaboam, C, Moore, TA, McKenzie, A, Wilke, CA, Chrisman, CJ and BB Moore. 2004. Protection from FITC-Induced Fibrosis in IL-13 Deficient, but not IL-4 Deficient Mice Results from Impaired Collagen Synthesis by Fibroblasts. J. Immunol. 172; 4068-4076.
33. Hildebrandt, GC, UA Duffner, KM Olkiweicz, LA Corrion, NE Willmarth, DL Williams, S. Clouthier, C Hogaboam, PR Reddy, BB Moore, C Liu, G Yanik, and KR Cooke. 2004 A Critical Role for CCR2:MCP-1 Interactions in the Development of Idiopathic Pneumonia Syndrome after Allogeneic Bone Marrow Transplantation. Blood.;103(6):2417-26.
34. Liu, T, Jin, H, Ullenbruch, M, Hu, B, Hashimotos, N, Moore, B, McKenzie, A. Lukacs, NW and SH Phan. 2004. Regulation of FIZZ1 Expression in Bleomycin-Induced Lung Fibrosis: Role of IL-4/IL-13 and Mediation via STAT-6. J. Immunol. 173:3425-3431.
35. Hildebrandt, GC, Corrion, LA, Olkiewicz, KM, Lu, B, Lowler, K, Duffner, UA, Moore, BB, Kuziel, WA, Liu, C and KR Cooke. 2004. Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome. J.Immunol. 173:2050-2059.
36. Moore, BB, Thannickal, VJ, and GB Toews, 2005. Bone-marrow derived cells in the pathogenesis of fibrosis. Current Respiratory Medicine Reviews. 1:69-76.
37. White, ES, Atrasz, RG, Dickie, EG, Aronoff, DM, Stambolic, V, Mak, TW, Moore, BB, and M Peters-Golden. 2005. Prostaglandin E2 inhibits fibroblast migration by EP2 receptor-mediated increase in PTEN activity. Am. J. Respir. Cell Mol Biol. 32:135-141.
38. Vittal, R., Horowitz, J.C., Moore, B.B., Zhang, H., Martinez, F.J., Toews, G.B., Standiford, T.J., and V.J. Thannickal. 2005. Modulation of pro-survival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury. Am. J. Pathol. 166:367-375.
39. Moore, BB, JE Kolodsick, VJ Thannickal, K Cooke, T.A. Moore, C Hogaboam, CA Wilke and GB Toews. 2005. CCR2-mediated recruitment of fibrocytes to the alveolar space following fibrotic injury and their differentiation into effector fibroblasts. Am. J. Pathol. 166:675-684.
40. Moore,BB, Ballinger, MN, White, ES, Green, M, Podsiad, A, Wilke, CA, Toews, GB and M.Peters-Golden. 2005. Bleomycin-Induced E Prostanoid Receptor Changes Alter Fibroblast Responses to Prostaglandin E2. J. Immunol.174(9):5644-9.
41. Stamatovic, SM., Shakui, P., Keep, R., Moore, BB., Kunkel, SL., Van Rooijen, N., and A.V Andjelkovic. 2005. Monocyte Chemoattractant Protein–1 Regulation of Blood Brain Barrier Permeability. J. Cereb. Blood Flow Metab. 25(5):593-606
42 Osterholzer, JJ, Ames T, Polak, T, Sonstein, Moore, BB, Chensue, SW Toews, GB and JL Curtis. 2005. CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. J. Immunol. 175(2):874-883.
43. Nethery, DE, Moore, BB, Minowada, G, Carroll, J, Faress, J.A. and JA Kern. 2005. Expression of Mutant Human Epidermal Receptor 3 (HER3) Attenuates Lung Fibrosis and Improves Survival in Mice. J. Appl. Physiol.99:298-307.
44. Choi, E.S., Pierce, E.M., Jakubzick, C., Carpenter K.J., Kunkel, S.L., Evanoff, H., Martinez, F.J., Flaherty, K.R., Moore, B.B., Toews, G.B. ,Colby, T.V., Kazerooni, E.A., Gross, B.H., Travis, W.D., and C. H. Hogaboam, 2006, Focal Interstitial CC Chemokine Receptor-7 (CCR7) Expression in Idiopathic Interstitial Pneumonia. J. Clin. Pathol. 59(1):28-39
45. Ballinger, MN, Paine, R., Serazani, C. H., Aronoff, D, M. , Choi, E.S., Standiford, TJ, Toews, GB and BB Moore. 2006. Role of GM-CSF During Gram Negative Lung Infection with Pseudomonas aeruginosa. Am. J. Resp. Cell Mol. Biol. 34(6):766- 774.
46. Moore, BB and Peters-Golden, M. 2006. Opposing roles of leukotrienes and prostaglandins in fibrotic lung disease. Expert Rev. of Clin. Immunol. 2006, 2:87- 100.
47. Moore, BB, Murray, LA, Das, A., Wilke, CA, Herrygers, AB and GB Toews. 2006. The role of CCL12 in the recruitment of fibrocytes and lung fibrosis. Am. J. Resp. Cell Mol. Biol. 35:175-181
48. Mendez, M., Morris, S. Moore, B.. and R. Paine. Shedding of Soluble ICAM-1 into the Alveolar Space in Murine Models of Acute Lung Injury, 2006. Am. J. Physiol. Lung Mol. Cell Physiol. 290(5):L962-70.
49. Lama, VN, Harada, H, Badri, LN, Flint, A, Hogaboam, CM, McKenzie, A, Martinez, FJ, Toews, GB, Moore, BB, Pinsky, DJ. 2006. Obligatory role for IL-13 in obstructive lesion development in airway allografts. Am. J. Pathol. 169:47-60.
50. Ballinger, MN, Aronoff, DM, McMillan, TR, Cooke, KR, Olkiewicz, K, Toews, GB, Peters-Golden, M and BB Moore. 2006. Critical Role of Prostaglandin E2 Overproduction in Impaired Pulmonary Host Response Following Bone Marrow Transplantation. J. Immunol. 177:5499-5508.
51. Ballinger, MN, McMillan, TR and BB Moore. 2007. Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Arch. Immunol. Ther. Exp.55:1-12.
52. Aronoff, D.M., Peres, C.M., Serezani, C.H., Ballinger, M.N., Carstens, J.K., Coleman, N., Moore, B.B., Peebles, R.S., Faccioli, L.H., and M Peters-Golden. 2007. Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities. J. Immunology 178(3):1628-34.
53. Vittal, R, Zhang, H, Moore, BB, Horowitz, JC and VJ Thannickal. 2007. 'Effects of the Protein Kinase Inhibitor, Imatinib Mesylate, on Epithelial/Mesenchymal Phenotypes: Implications for Treatment of Fibrotic Diseases. J. Pharm. Exp. Therap.321:35-44.
54. Hennrick, KT, Keeton, AG, Nanua, S, Kijek, TG, Goldsmith, AM, Sajjan, US, Bentley, JK, Lama, VN, Moore, BB, Schumacher, RE, Thannickal, VJ and MB Hershenson. 2007. Lung cells from neonates show a mesenchymal stem cell phenotype. Am. J. Resp. Crit. Care Med. 175(11):1158-64.
55. Thomas, PE, Peters-Golden, M, White, ES, Thannickal, VJ and BB Moore. PGE2 inhibition of TGF-β1-induced myofibroblast differentiation is SMAD-independent, but involves cell shape and adhesion-dependent signaling, 2007, Am. J. Physiol. Lung Cell Mol. Physiol. 293(2):L417-28.
56. Bommer, GT, Gerin, I., Feng, Y., Kaxzorowski, AJ, Kuick, R., Love, RE, Zhai, Y, Giordano, TJ, Qin, ZS, Moore, BB, MacDougald, OA, Cho, KR, and ER Fearon. 2007, p-53-mediated activation of miRNA34 candidate tumor suppressor genes, Current Biology 17(15):1298-307.
57. Collard, HR, Moore, BB, Flaherty, KR, Brown, KK, Kaner, RJ, King, TE, Lasky, JA, Loyd JE, Noth, I, Olman, MA, Raghu, G, Roman, J, Ryu, JH, Zisman, DA, Hunninghake, GW, Colby, TV, Egan JJ, Hansell, DM, Johkoh, T, Kaminski, N, Kim, DS, Kondoh, Y, Lynch, DA, Muller-Quernheim, J, Myers, JL, Nicholson, AG, Selman, M, Toews, GB, Wells, AU and FJ Martinez with the IPFNet investigators. 2007. Pulmonary Perspective: Acute Exacerbations of Idiopathic Pulmonary Fibrosis. Am J. Respir. Crit. Care Med. 176(7):636-643.
58. Hildebrandt, GC, Choi, SW, Mueller, G, Olkiewicz, KM, Moore, BB and KR Cooke. 2007. The absence of donor-derived IL-13 exacerbates the severity of acute graft versus host disease following allogeneic bone marrow transplantation. Ped. Blood Cancer 50(4):911-4.
59. Serezani, CH, Chung, J, Ballinger, MN, Moore, BB, Aronoff, DM and M Peters-Golden. 2007. Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by E prostanoid receptor 2/4-mediated inhibition of NADPH oxidase activation Am. J. Resp. Cell Mol. Biol. 37(5):562-70
60. Olszewski, MA, Falkowski, NR, Surana, R, Sonstein, J, Hartman, A, Moore, BB, Huffnagle, GB and GB Toews. 2007. Effect of Laparotomy on Clearance and Cytokine Induction in Staphylococcus aureus-infected Lungs. Am. J. Resp. Crit. Care Med. 176(9):921-9
61. Vannella, KM, McMillan, TR, Charbeneau, RP, Wilke, CA, Toews, GB, Peters-Golden, M, and BB Moore. 2007. Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function. J. Immunol. 179(11)7883-90.
62. Moore, BB and C.M. Hogaboam, 2008. Murine Models of Pulmonary Fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol. 294:L152-60.
63. White, KE, Ding, Q, Moore, BB, Peters-Golden, M, Ware, LB, Mathhay, MA and Olman, MA. 2008. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J. Immunol. 180:637-46.
64. Muro AF, Moretti, FA, Moore, BB, Yan, M., Atrasz, RG, Wilke, CA, Flaherty, KR, Martinez, FJ, Tsui, JL, Sheppard, D, Baralle, FE, Toews, GB, and Eric S. White. 2008. An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am. J. Resp. Crit. Care Med. 177:638-645.
65. McMillan,TR, Moore, BB, Weinberg, JB, Vannella, KM, Fields, WB, Christensen, PJ, van Dyk, LF and Toews, GB, 2008. Exacerbation of established pulmonary fibrosis in an animal model by gammaherpesvirus. Am. J. Respir. Crit. Care Med. 177(7):771-80.
66. Hubbard, LN Ballinger, MN, Wilke, CA and Moore, BB. 2008. Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post-Bone Marrow Transplantation. Exp. Lung Res. 34:263-275.
67. Ballinger, MN, Hubbard, LN, McMillan, TR, Toews, GB, Peters-Golden, M, Paine, R and BB Moore. 2008. Paradoxical role of alveolar macrophage-derived granulocyte macrophage colony stimulating factor in pulmonary host defense post-bone marrow transplantation. Am. J. Physiol. Lung Cell Mol. Physiol. 295(1):L114-22.
68. Vannella, KM and BB Moore. 2008. Viruses as Co-Factors in the Initiation or Exacerbation of Lung Fibrosis. Fibrogenesis and Tissue Repair 1:2.
69. Narala, VR, Smith, MR, Adapala, RK, Ranga, R, Moore, BB, Leff, T, Reddy, VD, Kondapi, AK and RC Reddy. 2009. Curcumin is not a ligand for peroxisome proliferator-activated receptor-γ Gene Ther Mol Biol Vol 13, 20-25. PMID: 19644570
70. Rumble, JM, Oetjen, KA, Stein, PL, Schwarzberg, PL, Moore, BB and CS Duckett. 2009. Distinct functional and biochemical properties of XIAP and SAP, Two factors targeted in X-linked lymphoproliferative syndrome (XLP). Cellular Immunol. 259:82-9. PMID: 19595300
71. Zhang, Y., F. Want, K.C. Tompkins, A. McNamara, A.V. Jain, B.B. Moore, G. B. Toews, G.B. Huffnagle and M.A. Olszewski. 2009. Robust Th1 and Th17 Immunity Supports Pulmonary Clearance but Cannot Prevent Systemic Dissemination of Highly Virulent C. neoformans H99. Am. J. Pathol.. 175:2489-500. PMID: 19893050.
72. Sagana, RL, Yan, M, Cornett, AM, Tsui, JL, Stephenson, DA, Huang, SK, Moore,BB, Ballinger, MN, Melonakos, J., Kontos, C.D., Aronoff, DM, Peters-Golden,M, and E.S. White. 2009. PTEN Directs PGE2-Mediated Fibroblast Responses via Regulation of E Prostanoid 2 Receptor Expression. J. Biol. Chem. 284:32264-71. PMID: 19808686
73. Sisson, TH, Mendez, M, Choi, K, Subbotina, N, Courey, A, Cunningham, A, Dave, A, Engelhardt, JF, Liu, X, White, ES, Thannickal, VJ, Moore, BB, Christensen, PJ and RH Simon. 2010. Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 181(3):254-63. PMID: 19850947
74. Vannella, KM, Luckhardt, TR, Wilke, CA, van Dyk, LF, Toews, GB and BB Moore. 2010. Latent herpesvirus infection augments experimental pulmonary fibrosis. Am.J. Respir. Crit. Care Med., 181:465-77. PMID#20185751
75. Coomes, S.M., Wilke, C.A., Moore, T.A. and B.B. Moore. 2010. Induction of Transforming Growth Factor-β1, not Regulatory T cells, Impairs Anti-Viral Immunity in the Lung Following Bone Marrow Transplant J. Immunol.184(9):5130-40. PMID: 20348421
76. Hubbard, L.N., M.N. Ballinger, P.E. Thomas, C.A. Wilke, T.J. Standiford, K.S. Kobayashi, R.A. Flavell and B.B. Moore. 2010. A role for IRAK-M in PGE2-Induced Immunosuppression Post-Bone Marrow Transplantation. J. Immunol. 184(11):6299-308. PMID: 20439918
77. Bauman, K.A., Wettlaufer, S.H., Okunishi, K., Vannella, K.M., Stoolman, J.S., Huang, S.K., Courey, A.J., White, E.S., Hogaboam, C.M., Simon, R.H., Toews, G.B., Sisson, T.H., Moore, B.B. and M. Peters-Golden. 2010. Anti-Fibrotic Actions of Plasminogen Activation are Mediated via Upregulation of Prostaglandin E2 Synthesis. J. Clin. Invest. 120(6):1950-60. PMID: 20501949
78. Hubbard, L.N. H. and B.B. Moore. 2010. The role of IRAK-M in innate immunity. Infectious Disease Reports 2e9.
79. White, E.S., Sagana, R.L., Booth, AJ, Yan, M., Cornett, A.M., Tsui,J.L., Wilke, C.A., Moore, B.B., Rizenthaler, J.D., Roman, J. and A. F.Muro. 2010. Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway. Exp Cell Res. 316:2644-53. (PMID:20615404)
80) Coomes, S.M. and B.B. Moore. 2010. Pleotropic effects of transforming growth factor beta in hematopoietic stem cell transplantation. Transplantation 90(11)1139-44.PMID: 20671593
81) Naik, P.N. and B. B. Moore. 2010. Viral Infection and Aging as Cofactors in the Development of Pulmonary Fibrosis. Expert Review of Respiratory Medicine 4(6)759-71.PMID: 21128751
82) Stoolman, J.S., Vannella, K.M., Coomes, S.M, Wilke, C.A., Sisson, T.H., Toews, G.B. and B.B. Moore. 2010. Latent Infection by Gammaherpesvirus Stimulates Pro-Fibrotic Mediator Release from Multiple Cell Types. Am. J. Physiol. Lung Cell Mol. Physiol. 300(2):L274-85. PMID 2103691
83) Matute-Bello, G., Downey, G, Moore, B.B., Groshong, S.D., Matthay, M.A., Slutsky, A.S. and W. M Kuebler on behalf of the Acute Lung Injury in Animals Study Group. 2011, An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals. Am. J. Respir. Cell Mol Biol. 44:725-738. PMID 21531958
84) Sun, L, Louie, M.C., Vannella, K.M, Wilke, C.A., LeVine, A.M., Moore,B.B. and T.P. Shanley. 2011. New concepts of IL-10 induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis. Am. J. Physiol. Lung Cell Mol. Physiol. 300 (3):L341-53. PMID: 21131395
85) Coomes, S.M, Hubbard, L.L.N. and B.B. Moore. Impaired Pulmonary Immunity post-Bone Marrow Transplant. 2011. Immunologic Research 50:78-86. PMID: 21170739
86) Luckhardt, TR, Coomes, SM, Trujillo, G, Stoolman, JS, Vannella, KM, Bhan, U, Wilke, CA, Moore, TA, Toews, GB, Hogaboam, C and BB Moore. 2011, TLR9-induced interferonβ is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis. Fibrogenesis and Tissue Repair 4:18. PMID:21810214
87) Bozyk, PD and BB Moore. 2011. Red in Translation Review “ProstaglandinE2 and the Pathogenesis of Pulmonary Fibrosis”. Am. J. Respir. Cell Mol. Biol.45(3):445-52. PMID:21421906
88) Hubbard, LLN, Wilke, CA, White, ES and B.B. Moore. 2011. PTEN limits alveolar macrophage function against P. aeruginosa following bone marrow transplantation. Am. J. Respir. Cell Mol Biol.45(5):1050-8.. PMID: 21527775
89) Coomes, SM, Farmen, S, Wilke, CA, Laouar, Y and BB Moore. 2011. Severe gammaherpesvirus-induced pneumonitis and fibrosis in syngeneic bone marrow transplant mice is related to effects of transforming growth factor-beta on multiple cell types. Am. J. Pathol. 179(5):2382-96. PMID: 21924228
90) Ballinger, MN, Peters-Golden, M and BB Moore, 2011, Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2 Respir. Res. 12(1):155 epub. PMID: 22141755
91) Bozyk, PD, Popova, AP, Bentley, JK, Anyanwu, AC, Linn, MD, Goldsmith, AM, Pryhuber, GS, Moore, BB and MB Hershenson. 2012. Periostin is required for the bronchopulmonary dysplasia phenotype in hyperoxic neonatal mice. PLOS One, 7(2)e31336 epub.
92) Naik, PN, Horowitz, JC, Moore, TA, Wilke, CA, Toews, GB and BB Moore, 2011, Pulmonary fibrosis induced by γherpesvirus in aged mice is associated with increased fibroblast responsiveness to TGFβ J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):714-25. PMID 22193547
93) Suresh, MV., Yu, B., Machado-Aranda,D., Bender, M.D., Ochoa-Frongia, L, Helinski, J.D.,Davidson, B.A., Knight, P.R., Hogaboam, C.M., Moore, B.B, Raghavendran, K. 2011. Role of CCL2 in acute inflammation following lung contusion. Am. J. Respir. Cell Mol. Biol. 46(6):797-806. PMID:22281985
94) Ballinger, MN, Newstead, MW, Zeng, X, Bhan, U, Horowitz, JC, Moore, BB, Pinsky, DJ and Standiford, TJ. 2011. TLR signaling prevents hyperoxia induced lung injury by protecting the alveolar epithelium from oxidant mediated death. J. Immunol., 189(1):356-64. PMID:22661086
95) Kovach, MA, Ballinger, MN, Newstead, MW, Zeng, X, Bhan, U, Yu, F., Moore, BB, Gallo, RL and TJ Standiford. 2012. Cathelicidin related antimicrobial peptide is required for effective lung mucosal immunity in Gram negative bacterial pneumonia J. Immunol. 189(1):304-11 PMID: 22634613
96) Domingo-Gonzalez, R., Huang SK, Laouar, Y, Wilke, CA and BB Moore, 2012. COX-2 expression is upregulated by DNA hypomethylation post-hematopoietic stem cell transplantation J. Immunol. 189(9):4528-36 PMID 23008450
97) Booth, AJ, Hadley,, R, Cornett,, AM, Dreffs,, AA, Matthes, SA, Tsui,JL, Weiss, K, Fiore, VF Barker, TH, Moore, BB, Martinez, FJ, Niklason,, LE, and White, ES. 2012. Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation Am. J. Respir. Crit. Care Med. Nov 1;186(9):866-76 PMID:22936357
98) Sisson TH, Maher T, Ajayi IO, King JE, Higgins PDR, Booth AJ, Sagana RL, Huang SK, White ES, Moore BB, Horowitz JC. Increased Survivin Expression Contributes to Apoptosis-resistance in IPF fibroblasts. Advances in Biosciences and Biotechnology 2012; 3(6A):657-664. DOI: 10.4236/abb.2012.326085
99) Gharaee-Kermani, M, Kasina, S, Moore, BB, and JA Macoska. 2012. CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis. PLoS one. 2012;7(11):e49278 PMID:23173053
100) Naik, PK, Bozyk, PD, Bentley, JK, Popova, AP, Birch, CM, Wilke, CA, Fry, CD, White, ES, Sisson, TH, Tayob, N, Carnemolla B., Flaherty, KR, Hershenson MB, Murray, S, Martinez, FJ , BB Moore and the COMET investigators. 2012. Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol. 303(12)L1046-56.
101) Idiopathic Pulmonary Fibrosis Clinical Research Network, Raghu G, Anstrom, KJ, King, TE Jr, Lasky JA, Martinez, FJ +147 collaborators including B. Moore. Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. 2012, N. Engl. J.Med. 366(21):1968-77.
Non-Peer Reviewed Publications
1. Moore, BB, Editorial: Fibrocytes as Potential Biomarkers in Idiopathic Pulmonary Fibrosis, 2009, Am. J. Resp. Crit. Care Med. 179:524-5.
2. Moore, B.B. Book Review “Principles of Molecular Virology, Fifth Edition” Microbe, 2012.
Articles Accepted for Publication
102) Ajayi, IO, Sisson, TH, Higgins, PDR, Booth, AJ, Sagana, RL, Huang, SK, White, ES, King, JE, Moore, BB and Horowitz, JC. 2013. X-Linked Inhibitor of Apoptosis Regulates Lung Fibroblast Resistance to Fas-mediated Apoptosis in Lung Fibroblasts, Am. J. Respir. Cell Mol. Biol. in press.
103) Moore, BB, Lawson, WE, Oury, TD, Sisson, TH, Raghavendran K and CM Hogaboam. 2013. Animal Models of Fibrotic Lung Disease. Am. J. Respir. Cell Mol. Biol. (in press)
104) Loomis-King, H and B.B. Moore. Fibrocytes in the Pathogenesis of Chronic Fibrotic Lung Disease. 2013, Current Respiratory Medicine Reviews (in press).
105) Loomis-King, H., Flaherty KR and BB Moore. Pathogenesis, Current Treatments and Future Directions for IPF. 2013 Current Opinions in Pharmacology (in press) NIHMS464458
106) Domingo-Gonzalez, R., Katz, S., Serezani, C.H., Moore T.A., LeVine, A.M., and B.B. Moore. 2013. PGE2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of P. aeruginosa and S. aureus post-bone marrow transplant. J. Immunol. (in press).
Articles Submitted for Publication
107) Su, GL, Bayliss, J, Wilke, C, Wang, SC and BB Moore. Murine resident Kupffer cell CD14 modulates the hepatic inflammatory response and liver injury after acetaminophen. 2013.
108) Nemzek, JA, Fry, C and BB Moore. Adoptive transfer of fibrocytes enhances splenic T cell numbers and survival in septic peritonitis. Shock, in revision, 2013.
109) Domingo-Gonzalez, R and BB Moore. Defective pulmonary innate immune responses post-stem cell transplant. 2013, Submitted to Front. Immunol. Res. Top.
Chapters in Books
1. Strieter, RM, Addison, CA, Moore, BB, and Arenberg, DA. The role of CXC chemokines in the regulation of angiogenesis in association with non-small cell lung cancer. In Chemokines in Disease. ed. C. Hebert, Humana Press, Totowa, NJ. 1999. p.171-189.
2. Moore, BB and Toews, GB. Humoral immunity in the lung. In Respiratory Infections Textbook. eds. MS Niederman, GA Sarosi, and J Glassroth. Lippincott, Williams and Wilkins. Philadelphia, PA. 2001. P.27-43.
3. Naik, P.N. and B. B. Moore. 2012. Fibrocytes Health and Disease, “Insights from Animal Models and Clinical Studies”. ed. Richard Bucala, World Scientific, Hackensack, NJ,. P143-170
Recent Abstracts (Last 2 years)
69. Naik, P, Wilke, C, Stoolman, J, Toews, G and B.B. Moore. Gammaherpesvirus infected aged mice have altered fibroblasts and epithelial cells. ATS International Conference, Denver, CO, May 15-18, 2011.
70. Bozyk, PD, Popova, AP, Bently, JK, Linn, MJ, Hershenson, MB, Moore, BB. Periostin secretion from lung-derived mesenchymal cells participate in fibrotic lung disease. ATS International Conference, Denver, CO, May 15-18, 2011.
71. Moore, BB, Coomes, SM and S. Farmen. Gammaherpesvirus-induced pneumonitis in murine bone marrow transplant model is associated with effects of transforming growth factor beta on T cells. ATS International Conference, Denver, CO, May 15-18, 2011
72. Moore, BB, Fry, CD, Wilke, CA and GB Toews. Circulating monocytes in idiopathic pulmonary fibrosis (IPF) patients express TLR9 and CD206. ATS International Conference, Denver, CO, May 15-18, 2011
73. White, ES, Cornett, AM, Cheng, L, Dreffs, AA, Yan, M, Sagana, RL, Booth, AJ, Moore, BB, Lama, VN, Hogaboam, CM, Schmidt, SL, Toews, GB, Flaherty, KR, Martinez, FJ and Kurtis, JD. High throughput plasma biomarker analysis in IPF reveals an extracellular matrix remodeling signature. ATS International Conference, Denver, CO, May 15-18, 2011
74. Coomes, SM, Farmen, S, Wilke, CA, Laouar, Y and B.B. Moore. Severe herpesvirus-induced pulmonary pathology post-syngeneic bone marrow transplant is related to effects of transforming growth factor-beta. American Association of Immunologists, Orlando, FL, May 15, 2011
75. Mandair, GS, Lopez, J, Moore, B.B and M.D.Morris. Raman spectroscopic assessment of lung tissue composition in mouse models of idiopathic pulmonary fibrosis, Federation of Analytical Chemists and Spectroscopy Societies, Reno, NV, Oct. 2, 2011.
76. Suresh, M.V., Bender, M.D., Yu, B. Machado-Arando, D., Moore, B.B., Raghavendran, K. Toll like receptor-3 is required for acute inflammatory response and injury in mice following lung contusion. ATS International Conference, San Francisco, CA, May 20-24, 2012.
77. Naik, PK, Bozyk, PD, Wilke, CA, Hershenson, MB, Toews, GB, Moore, BB. Periostin: a novel protein essential to the development of pulmonary fibrosis. ATS International Conference, San Francisco, CA, May 20-24, 2012.
78. Loomis-King, H., Coomes, S.M., Moore, B.B. The role of IL-17 in gammaherpesvirus-induced lung pathology in BMT mice. ATS International Conference, San Francisco, CA, May 20-24, 2012.
79. Horowitz, J.C. Ajayi, O, Sagana, R., White, ES, Moore, BB, Huang, SK and Sisson, TH. Expression of inhibitor of apoptosis proteins in normal and fibrotic lung fibroblasts. ATS International Conference, San Francisco, CA, May 20-24, 2012.
80. Moore, BB, Moore, TA, Fry, CD, Arenberg, DA, Bozyk, PD, Wilke, CA, Toews, GB, Flaherty, KR, Martinez, FJ and the COMET investigators. Fibrocytes are more readily detected in lung than circulation of IPF patients. ATS International Conference, San Francisco, CA, May 20-24, 2012.
81. Moore, BB, Domingo-Gonzalez, R., Huang, S. Methylation patterns of COX-2 promoter affect gene transcription and PGE2 levels post-BMT. ATS International Conference, San Francisco, CA, May 20-24, 2012.
82. Domingo-Gonzalez, R., Huang, S. , and B.B. Moore Methylation patterns of COX-2 promoter affect gene transcription and PGE2 levels post-BMT. American Association of Immunologists, Boston, MA, May 7, 2012.
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