WILLIAM L - The Murphy Group



Curriculum Vitae

William L. Murphy

Office Address: Room 5405 Wisconsin Institutes for Medical Research

1111 Highland Avenue

Madison, WI 53705

Telephone: (608) 265-9978

e-mail: wlmurphy@wisc.edu

Lab website: bioinspired.engr.wisc.edu

Laboratory Address: Wisconsin Institutes for Medical Research

1111 Engineering Drive

Madison, WI 53705

(608) 265-5933

Current Position: Harvey D. Spangler Professor

Department of Biomedical Engineering (50%)

Department of Orthopedics and Rehabilitation (50%)

Director

Forward BIO Institute

Director

Human MAPs Center

Biomanufacturing Thrust Leader

Grainger Institute for Engineering

Principal Investigator

Bioinspired Materials Laboratory

Research Interests: ● Bioinspired materials

● Biomaterials for stem cell biomanufacturing

● Biomaterials for drug and gene delivery

● Biomaterials for tissue regeneration

Education and Training:

2004 Postdoc University of Chicago, Chicago, IL

Department of Chemistry (Advisor: Prof. Milan Mrksich, Northwestern Univ)

Research area: Synthesis of novel materials, Protein engineering

2002 Ph.D. University of Michigan, Ann Arbor, MI

Department of Biomedical Engineering (Advisor: Prof. David Mooney, Harvard Univ)

Dissertation: Synthetic, Biomimetic ECMs to Direct Bone Tissue Regeneration

2000 M.S. University of Michigan, Ann Arbor, MI

Major: Biomedical Engineering, Focus: Macromolecular Science and Engineering

1998 B.A. Illinois Wesleyan University, Bloomington, IL

Major: Physics, Minor: Mathematics (Advisor: Prof. Gabriel Spalding)

Academic Appointments/Affiliations:

2018-present Director, Forward BIO Institute

University of Wisconsin, Madison, WI

2012-present Harvey D. Spangler Professor

Departments of Biomedical Engineering and Orthopedics & Rehabilitation

2012-2018 Co-Director

Stem Cell and Regenerative Medicine Center

University of Wisconsin, Madison, WI

2015-present Director

Human MAPs Center

University of Wisconsin, Madison, WI

2011-2017 Associate Director

Wisconsin Institute for Discovery “BioNaTES” Theme

University of Wisconsin, Madison, WI

2017-present Biomanufacturing Thrust Leader

Grainger Institute of Engineering

University of Wisconsin, Madison, WI

2011-2012 Associate Professor

Departments of Biomedical Engineering and Orthopedics & Rehabilitation

University of Wisconsin, Madison, WI

2004-2010 Assistant Professor

Departments of Biomedical Engineering, Pharmacology, and Orthopedics/Rehabilitation University of Wisconsin, Madison, WI

2004-present Professor (by courtesy)

Department of Materials Science and Engineering, University of Wisconsin

2007-present Executive Committee Member

Stem Cell and Regenerative Medicine Center, University of Wisconsin

2002-2004 Postdoctoral Fellow (NIH NRSA Fellow)

Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL

1998-2002 Graduate Research Assistant (NIH Biotechnology Training Fellow)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI

1998 Undergraduate Research Assistant

Department of Biomedical Engineering, Northwestern University

1997 Undergraduate Research Assistant (NSF-REU Fellow)

Department of Physics, University of Illinois, Champaign, IL

1996-1998 Undergraduate Research Assistant

Department of Physics, Illinois Wesleyan University, Bloomington, IL

Honors/Advisory Positions:

• Fellow, Biomedical Engineering Society (2020-Pres)

• Fellow, National Academy of Inventors (2019-Pres)

• Fellow, American Institute for Medical and Biological Engineering (2014-Pres)

• H.I. Romnes Award, University of Wisconsin (2016)

• Co-Founder and Chief Scientific Officer, Dianomi Therapeutics (2018-Pres)

• Co-Founder and Chief Scientific Officer, Stem Pharm (2016-Pres)

• Co-Founder and Scientific Advisor, Tissue Regeneration Systems Inc. (2006-2019)

Honors/Advisory Positions (Continued):

• Member, TERMIS Americas Council (2015-2017)

• Editor, Acta Biomaterialia, 2014-2019

• Executive Committee, Vascular Biology Training Program, Univ. of Wisconsin (2014-Pres.)

• Member, AO Research Review Commission, AO Foundation (2013-2019)

• Scientific Advisory Board, Morgridge Institute for Research (2013-Pres)

• Scientific Advisory Committee, International Stem Cell Engineering Conference (2014)

• Scientific Advisory Committee, Tissue Engineering and Regenerative Medicine Int Soc Conf (2013)

• Scientific Advisor, Venture Investors (2012-Pres), Primorigen Biosciences (2011-2014), Synthes (2011-2013), Eli Lilly (2011-2013), Platypus Technologies (2013-2017), Cellular Logistics (2017-Pres), JangoBio (2016-2017), Covance (2020-Pres).

• Vilas Associate Award, University of Wisconsin (2011-2012)

• Governing Council, Society for Biomaterials (2011-2014, 2017-Pres)

• Co-Founder and Scientific Advisor, Tissue Regeneration Systems Inc. (2006-2019)

• Editorial Boards, Advanced Functional Materials (2011-2019), Acta Biomaterialia (2009-2014), Biomacromolecules (2015-Pres), Tissue Engineering (2013-Pres), eCM Journal (2016-Pres), Journal of Biomedical Materials Research (2015-Pres), Biomatter (2010-Pres), NanoLIFE (2009-Pres)

• Associate Editor, Cells, Tissues, Organs (2013-2018)

• Featured in “Emerging Investigators” issues of Chemical Communications (2010), Soft Matter (2009), Biomaterials Science (2013)

• Selected co-organizer, U.S. Frontiers of Engineering Symp., National Academy of Engineering (2010)

• Selected Participant, U.S. Frontiers of Engineering Symp., National Academy of Engineering (2009)

• “Professor of the Year”, Univ. of Wisconsin Biomedical Engineering Department (2009)

• Executive Committee, UW Stem Cell and Regenerative Medicine Center (2008-Pres)

• National Science Foundation CAREER Award (2008)

• Guest Editor, Special Issue “Self Assembling Biomaterials”, Acta Biomaterialia (2009)

• UW Teaching Academy Award (2005)

• IADR/AADR William J. Gies Award for Best Published Paper in Journal of Dental Research (2005)

• NIH National Research Service Award, Postdoctoral Fellowship (2003-2004)

• NIH Cellular Biotechnology Predoctoral Fellowship (2000-2002)

• Biomedical Engineering Society Outstanding Graduate Research Award (2002)

• Materials Research Society Graduate Student Award (2000)

• NSF Research Experience for Undergraduates Fellowship (1997)

Professional Society Memberships (during the past 10 years):

• Biomedical Engineering Society

• American Chemical Society

• Materials Research Society

• Society for Biomaterials

• Society of Toxicology

• International Society for Stem Cell Research

• Tissue Engineering and Regenerative Medicine International Society

• IEEE-Engineering in Medicine and Biology Society

• Orthopedic Research Society

• American Heart Association

Publications

Journal Publications (Murphy Lab Members are Underlined):

1. W.L. Murphy, G.C. Spalding. Range of interactions: An experiment in atomic and magnetic force microscopy. American Journal of Physics 1999;67:905-909.

2. W.L. Murphy, D.J. Mooney. Controlled delivery of inductive proteins, plasmid DNA, and cells from tissue engineering matrices. Journal of Periodontal Research 1999;34:413-419.

3. W.L. Murphy, P.B. Messersmith. Compartmental control of mineral formation: adaptation of a biomineralization strategy for biomedical use. Polyhedron 2000;19:357-363.

4. W.L. Murphy, D.H. Kohn, D.J. Mooney. Growth of continuous bone-like mineral within porous poly(lactide-co-glycolide) scaffolds in vitro. Journal of Biomedical Materials Research 2000;50:50-58 (Cover Article).

5. W.L. Murphy, M.C. Peters, D.H. Kohn, D.J. Mooney. Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. Biomaterials 2000;24:2521-2527.

6. W.L. Murphy and P.B. Messersmith. Thermally Triggered Mineralization of Calcium Phosphate Using Phosphate-Loaded Liposomes. In: Chemistry and Biology of Mineralized Tissues, M. Goldberg, A. Boskey, C. Robinson, eds., AAOS, Rosemont, IL, 2000:393-397.

7. T.P. Richardson, W.L. Murphy, D.J. Mooney. Polymeric delivery of proteins and plasmid DNA for tissue engineering and gene therapy. Critical Reviews in Eukaryotic Gene Expression 2001;11:47-58.

8. W.L. Murphy, D.J. Mooney. Molecular-scale biomimicry. Nature Biotechnology 2002;20:30.

9. W.L. Murphy, R.G. Dennis, J.L. Kileny, D.J. Mooney. Salt fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Engineering 2002;8:43-52.

10. W.L. Murphy, D.J. Mooney. Bioinspired growth of crystalline carbonate apatite on biodegradable polymer substrata. Journal of the American Chemical Society 2002;124:1910-1917.

11. W.L. Murphy, D.J. Mooney. Tissue Engineering in Orthodontics. Chapter 22 In: Essentials for Orthodontic Practice. J. Avery, Ed, 2002.

12. T.P. Richardson, W.L. Murphy, D.J. Mooney. Selective adipose tissue ablation by localized, sustained drug delivery. Plastic and Reconstructive Surgery 2003;112:162-170.

13. W.L. Murphy, C.A. Simmons, D. Kaigler, D.J. Mooney. Bone regeneration via a mineral substrate and induced angiogenesis. Journal of Dental Research 2004;83:204-210. (Awarded the 2005 IADR/AADR William Gies Award for best Bioengineering/Biomaterials paper in JDR in 2004)

14. W.L. Murphy, K.O. Mercurius, S. Koide, M. Mrksich. Substrates for cell adhesion prepared via active site-directed immobilization of a protein domain. Langmuir 2004;20:1026-1030.

15. W.L. Murphy, S. Hsiong, T.P. Richardson, C.A. Simmons, D.J. Mooney. Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials 2005;26:303-310.

16. Jason L. Wyman, Seda Kizilel, Ryan Skarbek, Xiangyang Zhao, Matthew Connors, William S. Dillmore, William L. Murphy, Milan Mrksich, Sidney R. Nagel, Marc R. Garfinkel. Immunoisolating Pancreatic Islets by Encapsulation with Selective Withdrawal. Small, 2007;3:683-690.

17. W.L. Murphy, W.S. Dillmore, J. Modica, M. Mrksich. Dynamic Hydrogels: Translating a Protein Conformational Change into Macroscopic Motion. Angewandte Chemie Int. Ed., 2007;46:3066-3069. (Featured in Editor’s Choice section, Science, 05/2007)

18. W.L. Murphy, K. Grorud, R. Vanderby. Healing of Bone and Connective Tissues. In: Encyclopedia of Biomaterials and Biomedical Engineering, G. Wnek, G. Bowlin, Eds., 2007.

19. K.S. Masters, W.L. Murphy. Tissue Engineering. In: Encyclopedia of Medical Devices and Instrumentation, J.G. Webster, Ed., 2007.

20. Z. Sui, W.J. King, W.L. Murphy. Dynamic materials based on a protein conformational change. Advanced Materials, 2007;19:3377-3380. (Featured in Advances in Advance section, Adv Mat, 10/2007)

21. G. Hudalla, T.S. Eng, W.L. Murphy. An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks, Biomacromolecules, 2008; 9:842-849.

22. L. Jongpaiboonkit, W.J. King, G.E. Lyons, A. Paguirigan, J. Warrick, D.J. Beebe, W.L. Murphy, An adaptable hydrogel array format for 3-dimensional cell culture and analysis, Biomaterials, 2008;29:3346-3356.

23. Z. Sui, W.J. King, W.L. Murphy. Protein-based hydrogels with tunable dynamic responses, Advanced Functional Materials, 2008;18:1824-1831.

24. S. Choi, W.L. Murphy. Multifunctional mixed SAMs that promote both cell adhesion and non-covalent DNA immobilization, Langmuir, 2008; 24:6873-6880.

25. B.J. Peret, W.L. Murphy. Controllable soluble protein concentration gradients in hydrogel networks, Advanced Functional Materials, 2008; 18: 3410-3417.

26. J.W. Warrick, W.L. Murphy, D.J. Beebe. Screening the cellular microenvironment: A role for microfluidics. IEEE Review of Biomedical Engineering, 2008; 1: 75-94.

27. D. Suarez-Gonzalez, W.L. Murphy. Bio-Inspired Growth of Mineralized Tissues. In: Biomineralization: from Nature to Application. A. Sigel, H. Sigel, R.K.O. Sigel, Eds., 2008.

28. L. Jongpaiboonkit, W.J. King, W.L. Murphy. Screening for 3-D environments that support human mesenchymal stem cell viability using hydrogel arrays, Tissue Engineering A, 2009;15:343-353.

29. L. Jongpaiboonkit, T. Franklin-Ford, W.L. Murphy. Mineral-coated polymer microspheres for controlled protein binding and release, Advanced Materials, 2009;21:1960–1963.

30. W.L. Murphy, J.H. Collier. Self-assembling biomaterials, Acta Biomaterialia, 2009;5:803-804.

31. G.A. Hudalla, W.L. Murphy. Using "click" chemistry to prepare SAM substrates to study stem cell adhesion, Langmuir, 2009;25:5737-5746.

32. J. Shaikh Mohammed, W.L. Murphy. Bioinspired design of dynamic materials. Advanced Materials, 2009;21:2361-2374.

33. W.J. King, J.Shaikh Mohammed, W.L. Murphy. Modulating growth factor release from hydrogels via a protein conformational change. Soft Matter, 2009; 5: 2399-2406.

34. K.J. Regehr, M. Domenech, J.T. Koepsel, K.C. Carver, S.J. Ellison-Zelski, W.L. Murphy, L.A. Schuler, E.T. Alarid, D.J. Beebe. Biological implications of polydimethylsiloxane-based microfluidic cell culture, Lab on a Chip, 2009; 9: 2132-2139.

35. J.S. Lee, J.S. Lee, A. Wagoner-Johnson, W.L. Murphy. Modular peptide growth factors for substrate-mediated stem cell differentiation, Angewandte Chemie Int. Ed., 2009; 48: 6266-6270.

36. L. Jongpaiboonkit, T. Franklin-Ford, W.L. Murphy. Growth of hydroxyapatite coatings on biodegradable polymer microspheres, ACS Applied Materials and Interfaces, 2009; 1: 1504-1511.

37. J.T. Koepsel, W.L. Murphy. Patterning discrete stem cell culture environments via localized SAM replacement, Langmuir, 2009; 25: 12825-34.

38. Y. Lu, M.D. Markel, B. Nemke, J.S. Lee, B.K. Graf, W.L. Murphy. Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model, Arthroscopy, 2009; 20: 1427-34.

39. Z. Sui, W.L. Murphy. Nanoscale Mechanisms for Assembly of Biomaterials. In: Nanoscience and its applications to Biomedicine, D. Shi, Ed., 2009.

40. J.S. Lee, J.S. Lee, W.L. Murphy. Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces, Acta Biomaterialia, 2010; 6: 21-28.

41. W.J. King, L. Jongpaiboonkit, W.L. Murphy. Influence of FGF2 and PEG hydrogel matrix properties on hMSC viability and spreading, Journal of Biomedical Materials Research A, 2010; 93:1110-1123.

42. G.A. Hudalla, W.L. Murphy. Immobilization of peptides with distinct biological activities onto stem cell culture substrates using orthogonal chemistries. Langmuir, 2010; 26: 6449-6456.

43. W.J. King, N.J. Pytel, K. Ng, W.L. Murphy. Triggered drug release from dynamic microspheres via a protein conformational change. Macromolecular Bioscience, 2010; 10: 580-584 (Cover Article, featured in “Best of Macromolecular Journals 2011”).

44. S.K. Lan-Levengood, W.L. Murphy. Biomaterials for high-throughput stem cell culture. Current Stem Cell Research and Therapy. 2010; 5: 261-267.

45. S.Y. Choi, W.L. Murphy. Sustained plasmid DNA release from dissolving mineral coatings. Acta Biomaterialia, 2010; 6: 3426-3435.

46. N. Zhang, J. Molenda, W.L. Murphy, J. Fournelle, N. Sahai. Effects of pseudowollastonite (CaSiO3) bioceramic on in vitroactivity of human mesenchymal stem cells. Biomaterials, 2010; 31: 7653-7665.

47. D. Suarez-Gonzalez, K. Barnhart, E. Saito, R. Vanderby, Jr., Scott J. Hollister, W.L. Murphy. Controlled nucleation of hydroxyapatite on alginate scaffolds for stem cell-based bone tissue engineering, Journal of Biomedical Materials Research A, 2010; 95: 222-34.

48. J.S. Lee, Y. Lu, G.S. Baer, M.D. Markel, W.L. Murphy. Controllable protein delivery from coated surgical sutures. Journal of Materials Chemistry, 2010, 20, 8894-8903.

49. J.S. Lee, A. Wagoner-Johnson, W.L. Murphy. A modular, hydroxyapatite-binding version of vascular endothelial growth factor. Advanced Materials, 2010; 22: 5494-5498. (Featured on Cover; Featured in as “very important and very urgent”).

50. J.T. Koepsel, W.L. Murphy. Spatial localization of growth factors to regulate stem cell fate. In: Stem Cells and Revascularization Therapies, A. Putnam, H.J. Kong, L. Schook, Eds., 2011.

51. M. Toepke, W.L. Murphy. Dynamic Hydrogels. In: Comprehensive Biomaterials, K. Healy, P. Ducheyne, J. Kirkpatrick, D. Hutmacher, Eds., 2011.

52. W.J. King, M. Toepke, W.L. Murphy. A general route for the synthesis of functional, protein-based hydrogel microspheres using tailored protein charge. Chemical Communications, 2011; 47: 526-528. (Featured in “Emerging Investigators” issue).

53. W.J. King, M. Toepke, W.L. Murphy. Facile formation of dynamic hydrogel microspheres for triggered growth factor delivery. Acta Biomaterialia, 2011; 7: 975-985.

54. W.J. King, W.L. Murphy. Bioinspired conformational changes: an adaptable mechanism for bio-responsive drug delivery. Polymer Chemistry. 2011; 2: 476-491.

55. E. Nguyen, M.P. Schwartz, W.L. Murphy. Biomimetic approaches to control soluble protein concentration gradients in biomaterials. Macromolecular Bioscience, 2011; 11: 483-492.

56. W.L. Murphy. Emerging area: Biomaterials that mimic and exploit protein motion. Soft Matter, 2011; 7: 3679-3688. (Featured as “Hot Article” in Soft Matter).

57. G.A. Hudalla, W.L. Murphy. Biomaterials that regulate growth factor activity via bioinspired interactions. Advanced Functional Materials, 2011; 21: 1754-1768. (Featured in as “very important and very urgent”).

58. G.A. Hudalla, W.L. Murphy. Chemically well-defined self-assembled monolayers for cell culture: Toward mimicking the natural ECM. Soft Matter, 2011; 7: 9561 - 9571. (Featured as “Hot Article” in Soft Matter).

59. G.A. Hudalla, N. Kouris, J.T. Koepsel, B.M. Ogle, W.L. Murphy. Harnessing endogenous growth factor activity modulates stem cell behavior. Integrative Biology, 2011; 3: 832–842.

60. Y. Lu, J.S. Lee, B. Nemke, G. Baer, B. Graf, W.L. Murphy*, M.D. Markel. Histologic evaluation of suture material loaded with basic fibroblast growth factor (bFGF) on acute rotator cuff repair in an ovine model. Current Orthopaedic Practice, 2011; 22: 425-431. (*Corresponding Author).

61. J.S. Lee, D. Suarez-Gonzalez, W.L. Murphy. Mineral coatings for temporally controlled delivery of multiple proteins. Advanced Materials, 2011; 23: 4279–4284. (Featured as Frontispiece in Advanced Materials).

62. S.J. Hollister, W.L. Murphy. Scaffold translation: barriers between concept and clinic. Tissue Engineering B, 2011; 17: 459-474.

63. G.A. Hudalla, J.T. Koepsel, W.L. Murphy. Surfaces that sequester serum-borne heparin amplify growth factor activity. Advanced Materials, 2011; 23: 5415-5418.

64. D. Suarez-Gonzalez, K. Barnhart, F. Migneco, L.R. Eichacker, C. Flanagan, S.J. Hollister, W.L. Murphy. Controllable mineral coatings on PCL scaffolds as carriers for growth factor release. Biomaterials, 2012; 33: 713-21.

65. M.J. Wilson, S.J. Liliensiek, C.J. Murphy, W.L. Murphy, P.F. Nealey. Hydrogels with well-defined peptide-hydrogel spacing and concentration: impact on epithelial cell behavior. Soft Matter, 2012; 8: 390-398.

66. D. Suarez-Gonzalez, J.S. Lee, S.K. Lan Levengood, R. Vanderby Jr., W.L. Murphy. Mineral coatings modulate β-TCP stability and enable growth factor binding and release. Acta Biomaterialia, 2012; 8: 1117-1124.

67. N.A. Impellitteri, M.W. Toepke, S.K. Lan Levengood, W.L. Murphy. Specific VEGF sequestering and release using peptide-functionalized hydrogel microspheres. Biomaterials, 2012; 33: 3475-3484.

68. W.J. King, N. Kouris, S.Y. Choi, B.M. Ogle, W.L. Murphy. Environmental parameters influence non-viral transfection of human mesenchymal stem cells for tissue engineering applications. Cell and Tissue Research, 2012; 347: 689-699.

69. H.S. Haase, K.J. Peterson-Kaufman, S.K. Lan Levengood, J.W. Checco, W.L. Murphy*. S.H. Gellman*. Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling. Journal of the American Chemical Society, 2012; 134: 7652-7655. (Featured in Virtual Issue on “Peptide Chemistry” based on scientific quality and broad appeal).

70. M.W. Toepke, N.A. Impellitteri, S.K. Lan Levengood, D.S. Boeldt, I.M. Bird, W.L. Murphy. Regulating specific growth factor signaling using immobilized branched ligands. Advanced Healthcare Materials, 2012; 1: 457–460.

71. J.T. Koepsel, E.W. Nguyen, W.L. Murphy. Differential effects of a soluble or immobilized VEGFR-binding peptide. Integrative Biology, 2012; 4: 914-924.

72. J.T. Koepsel, W.L. Murphy. Patterned SAM substrates: Efficient, chemically-defined tools for cell biology, ChemBioChem, 2012; 13:1717-1724.

73. J.T. Koepsel, P.T. Brown, S.G. Loveland, W.J. Li, W.L. Murphy. Combinatorial screening of chemically-defined human mesenchymal stem cell culture substrates. Journal of Materials Chemistry, 2012; 22: 19474-19481.

74. J.T. Koepsel, S.G. Loveland, M.P. Schwartz, S. Zorn, D.G. Belair, N.N. Le, W.L. Murphy. A chemically-defined screening platform reveals behavioral similarities of primary human mesenchymal stem cells and endothelial cells. Integrative Biology, 2012; 4: 1508–1521.

75. S.Y. Choi, W.L. Murphy. The effect of mineral coating morphology on mesenchymal stem cell attachment and expansion. Journal of Materials Chemistry, 2012; 22: 25288-25295.

76. Y. Lu, J.S. Lee, B. Nemke, B.K. Graf, K. Royalty, R. Illgen III, R. Vanderby Jr., M.D. Markel, W.L. Murphy. Coating with a modular bone morphogenetic peptide promotes healing of a bone-implant gap in an ovine model. PLoS One, 2012; 7: e50378.

77. T. Franklin-Ford Ellis, N. Shah, E. Leiferman, C. Chamberlain, A. Raval, R. Vanderby, W.L. Murphy. Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles. Macromolecular Bioscience, 2012; 12: 1615–1621.

78. J.A. Burdick, W.L. Murphy. Moving from static to dynamic complexity in hydrogel design. Nature Communications, 2012; 3: 1269.

79. M.J. Wilson, Y. Jiang, B. Yanez-Soto, S.J. Liliensiek, W.L. Murphy, P.F. Nealey. Arrays of topographically and peptide-functionalized hydrogels for analysis of biomimetic extracellular matrix properties. Journal of Vacuum Science and Technology B, 2012; 30: 06F903-1-06F903-7.

80. T. Franklin-Ford, J.S. Lee, D. Suarez-Gonzalez, W.L. Murphy. Biomimetic Hydroxyapatite Materials for Therapeutic Delivery. CRC Handbook of Hydroxyapatite for Biomedical Applications. S. Zhang, Ed., 2012.

81. J.S. Lee, W.L. Murphy. Functionalizing calcium phosphate biomaterials with antibacterial silver particles. Advanced Materials, 2013; 25: 1173–1179.

82. S.Y. Choi, X. Yu, L. Jongpaiboonkit, S.J. Hollister, W.L. Murphy. Inorganic coatings for optimized non-viral transfection of stem cells. Scientific Reports, 2013; 3: 1567.

83. S.Y. Choi, W.L. Murphy. A screening approach reveals the influence of mineral coating morphology on human mesenchymal stem cell differentiation. Biotechnology Journal, 2013; 8: 496-501. (Featured in “In this issue” section of Biotechnology Journal).

84. S.H. Brounts, J.S. Lee, S. Weinberg, S.K. Lan Levengood, E.L. Smith, W.L. Murphy. High affinity binding of an engineered, modular peptide to bone tissue. Molecular Pharmaceutics, 2013;10:2086-90.

85. M.W. Toepke, N.A. Impellitteri, J.M. Theisen, W.L. Murphy. Characterization of thiol-ene crosslinked PEG hydrogels. Macromolecular Materials and Engineering, 2013; 298: 699-703.

86. M.B. Parlato, W.L. Murphy. Hydrogels for Autologous Stem Cell Recruitment. In: Hydrogels in Cell-Based Therapies. I. Hamley, C. Connon, Eds.

87. H. Ardalani, A. Assadi, W.L. Murphy. Structure, function, and development of blood vessels: lessons for tissue engineering. In: Engineering in Translational Medicine. W. Cai, Editor.

88. E. Saito, D. Suarez-Gonzalez, R. Rao, J. Stegemann, W.L. Murphy, S.J. Hollister. Use of micro-computed tomography to non-destructively characterize biomineral coatings on solid freeform fabricated poly (L-lactic acid) and poly (ε-caprolactone). Tissue Engineering C, 2013;19:507-517.

89. C.S. Chamberlain, E.M. Leiferman, K.E. Frisch, S.L. Brickson, W.L. Murphy, G.S. Baer, R. Vanderby. Interleukin expression after injury and the effects of interleukin-1 receptor antagonist. PLoS One 2013;8:e71631.

90. S.K. Schmitt, W.L. Murphy, P. Gopalan. Crosslinked PEG mats for peptide immobilization and stem cell adhesion. Journal of Materials Chemistry B 2013, 1, 1349-1360.

91. Nianli A. Zhang, James A. Molenda, William L. Murphy, Steven Mankoci, Xianfeng Zhou, Nita Sahai. Crystal structures of CaSiO3 polymorphs control growth and osteogenic differentiation of human mesenchymal stem cells on bioceramic surfaces, Biomaterials Science, 2013;1:1101-1110.

92. D. Belair, W.L. Murphy. Specific VEGF sequestering to biomaterials: influence of serum stability. Acta Biomaterialia 2013; 9: 8823–8831.

93. M. Parlato, A. Johnson, G.A. Hudalla, W.L. Murphy. Adaptable poly(ethylene glycol) microspheres capable of mixed mode degradation. Acta Biomaterialia, 2013; 9: 9270–9280.

94. K.E. Healy, T.C. McDevitt, W.L. Murphy, R.M. Nerem. Engineering the emergence of stem cell therapeutics. Science Translational Medicine, 2013;5:207.

95. M.P. Schwartz, S.P. Singh, J.Y. Lee, S.G. Loveland, J.T. Koepsel, R.E. Rogers, S.I. Montanez-Sauri, K.E. Sung, E.K. Sackmann, E.Y. Tokuda, L.M. Everhart, E.H. Nguyen, Y. Sharma, M.H. Zaman, D.J. Beebe, N.G. Ahn, W.L. Murphy, K.S. Anseth. A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype. PLoS One, 2013; 8: e81689.

96. Z. Hou, J. Zhang, M.P. Schwartz, R. Stewart, C.D. Page, W.L. Murphy, J.A. Thomson. A human pluripotent stem cell platform for assessing developmental neural toxicity screening. Stem Cell Research and Therapy, 2013; 4: S12.

97. E.H. Nguyen, M. Zanottelli, W.L. Murphy. Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays. Biomaterials, 2014; 35: 2149-2161.

98. A.S. Khalil, A.W. Xie, W.L. Murphy. Context clues: how do stem cells respond to their intrinsic environment? ACS Chemical Biology, 2014; 9: 45-56.

99. T. Hansen, J.T. Koepsel, S. Zorn, N.N. Le, M. Parlato, S.G. Loveland, M.P. Schwartz, W.L. Murphy. Biomaterial arrays with defined adhesion ligand densities and matrix stiffness identify distinct phenotypes for tumorigenic and non-tumorigenic human mesenchymal cell types. Biomaterials Science, 2014; 2: 745-756.

100. W.F. Hynes, N.J. Doty, T.I. Zarembinski, M.P. Schwartz, M.W. Toepke, W.L. Murphy, S.K. Atzet, R. Clark, J.A. Melendez, N.C. Cady. Micropatterning of 3D microenvironments for living biosensor applications. Biosensors, 2014, 4, 28-44.

101. S.M. Kennedy, K.A. Beres, A.R. Hahn, S.J. Kamin, S.C. Hagness, J.H. Booske, W.L. Murphy. Cationic Peptide exposure enhances pulsed-electric-field-mediated membrane disruption. PLoS One, 2014; 9: e92528.

102. W.L. Murphy, T.C. McDevitt, A.J. Engler. Materials as stem cell regulators. Nature Materials, 2014; 13: 547-557.

103. M. Parlato, Sarah Reichert, Neal Barney, W.L. Murphy. Poly(ethylene glycol) hydrogels with adaptable mechanical and degradation properties for biomedical applications. Macromolecular Bioscience, 2014; 14: 687-698.

104. C. Chamberlain, E. Leiferman, S. Brickson, G. Baer, W.L. Murphy, R. Vanderby. Interleukin-1 Receptor Antagonist Modulates Inflammation and Scarring after Ligament Injury. Connective Tissue Research, 2014; 55; 177-186.

105. X. Yu, P.N. Dang, A.S. Khalil, E. Alsberg, W.L. Murphy. Tunable dual growth factor delivery using multilayered microparticles with controllable degradation kinetics. Advanced Functional Materials, 2014; 24: 3082–3093.

106. D.G. Belair, A.S. Khalil, W.L. Murphy. Combining affinity and diffusion to model specific growth factor release in serum-containing environments. Biomacromolecules, 2014; 15: 2038-2048.

107. D. Suarez-Gonzalez, J.S. Lee, A. Diggs, Y. Lu, B. Nemke, M. Markel, S.J. Hollister, W.L. Murphy. Controlled multiple growth factor delivery from bone tissue engineering scaffolds. Tissue Engineering A, 2014; 20: 2077-2087.

108. Yu X, Takayama T, Goel SA, Shi X, Zhou Y, Kent KC, Murphy WL, Guo LW. A rapamycin-releasing perivascular polymeric sheath produces highly effective inhibition of intimal hyperplasia. Journal of Controlled Release, 2014; 191: 47–53.

109. S. Musah, P.J. Wrighton, Y. Zaltsman, X. Zhong, S. Zorn, M.B. Parlato, C. Hsiao, S.P. Palecek, Q. Chang, W.L. Murphy, L.L. Kiessling. Substratum-induced differentiation of human pluripotent stem cells reveals YAP as a potent regulator of neuronal specification. Proceedings of the National Academy of Sciences, 2014; 111: 13805-13810.

110. X. Yu, W.L. Murphy. 3-D scaffold platform for optimized non-viral transfection of multipotent stem cells. Journal of Materials Chemistry B, 2014; 2: 8186-8193.

111. D.G. Belair, N.N. Le, W.L. Murphy. Design of growth factor sequestering biomaterials. Chemical Communications, 2014; 50: 15651-15668.

112. E. Saito, D. Suarez-Gonzalez, W.L. Murphy, S.J. Hollister. Biomineral coating increases in vivo bone formation by ex-vivo BMP-7 gene therapy in rapid prototyped poly (L-lactic acid) (PLLA) and poly (ε-caprolactone) (PCL) porous scaffolds. Advanced Healthcare Materials, 2015; 4: 621-632.

113. C.S. Chamberlain, J.S. Lee, E.M. Leiferman, N.X. Maassen, G.S. Baer, R. Vanderby, W.L. Murphy. Effects of BMP-12 releasing sutures on Achilles tendon healing. Tissue Engineering A, 2015; 21: 916-27.

114. J.W. Checco, D.F. Kreitler, N.C. Thomas, D.G. Belair, N.J. Rettko, W.L. Murphy*, K.T. Forest*, S.H. Gellman*. Targeting diverse protein-protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold. Proceedings of the National Academy of Sciences, 2015; 112: 4552-4557.

115. X. Yu, D. Suarez-Gonzalez, A.S. Khalil, W.L. Murphy. How does the pathophysiological context influence delivery of bone growth factors? Advanced Drug Delivery Reviews, 2015; 84: 68–84.

116. D.G. Belair, J.A. Whisler, J. Valdez, J. Velazquez, J.A. Molenda, V. Vickerman, R. Lewis, C. Daigh, T.D. Hansen, D.A. Mann, J.A. Thomson, L.G. Griffith, R.D. Kamm, M.P. Schwartz, W.L. Murphy. Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. Stem Cell Reviews and Reports, 2015; 11: 511-525.

117. S.K. Schmitt, A.W. Xie, R.M. Ghassemi, D.J. Trebatoski, W.L. Murphy, P. Gopalan. Polyethylene glycol coatings on plastic substrates for chemically defined stem cell culture. Advanced Healthcare Materials, 2015; 4: 1555-1564.

118. J.A. Martin, A.H. Biedrzycki, S.H. Brounts, W.L. Murphy, M.D. Markel, R.J. DeWall, K.S. Lee, D.G. Thelen. In vivo measures of shear wave speed as a predictor of tendon elasticity and strength. Ultrasound in Medicine and Biology, 2015; 41: 2722-2730.

119. J.W. Checco, E.F. Lee, M. Evangelista, N.J. Sleebs, K. Rogers, A. Pettikiriarachchi, N.J. Kershaw, G.A. Eddinger, D.G. Belair, J.L. Wilson, C.H. Eller, R.T. Raines, W.L. Murphy, B.J. Smith, S.H. Gellman, W.D. Fairlie. α/β-Peptide foldamers targeting intracellular protein-protein interactions with activity in living cells. Journal of the American Chemical Society, 2015; 137: 11365-11375.

120. L.D. Solorio, L.M. Phillips, A. McMillan, C.W. Cheng, P.N. Dang, J.E. Samorezov, X. Yu, W.L. Murphy, E. Alsberg. Spatially organized differentiation of mesenchymal stem cells within biphasic microparticle-incorporated high cell density osteochondral tissues. Advanced Healthcare Materials, 2015; 4: 2306-13.

121. M.P. Schwartz, Z. Hou, N.E. Propson, J. Zhang, V.S. Costa, P. Jiang, B.K. Nguyen, J. Bolin, C. Engstrom, W. Daly, Y. Wang, R. Stewart, C.D. Page, W.L. Murphy, J.A. Thomson. Human pluripotent stem cell-derived neural constructs for predictive neurotoxicity. Proceedings of the National Academy of Sciences, 2015; 112: 12516-21.

122. S. Pellett, M.P. Schwartz, W.H. Tepp, R. Josephson, J.M. Scherf, C.L. Pier, J.A. Thomson, W.L. Murphy, E.A. Johnson. Human induced pluripotent stem cell derived neuronal cells cultured on chemically-defined hydrogels for sensitive in vitro detection of botulinum neurotoxin. Scientific Reports, 2015; 5: 14566.

123. Y. Wang, X. Yu, C. Baker, W.L. Murphy, T.C. McDevitt. Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates. Acta Biomaterialia, 2016; 29: 42–51.

124. P. Dang, L. Solorio, S. Herberg, N. Dwivedi, L. Phillips, C. Bowerman, X. Yu, W.L. Murphy, E. Alsberg. Controlled growth factor delivery from microparticles incorporated within hMSC aggregates for enhanced bone tissue engineering via endochondral ossification. Stem Cells Translational Medicine, 2016; 5: 206-217.

125. S.K. Schmitt, D.J. Trebatoski, J.D. Krutty, A.W. Xie, B. Rollins, W.L. Murphy, P. Gopalan. Peptide conjugation to a polymer coating via native chemical ligation of azlactones for cell culture. Biomacromolecules, 2016; 17: 1040-1047.

126. N.N.T. Le, S. Zorn, S.K. Schmitt, P. Gopalan, W.L. Murphy. Hydrogel arrays formed via differential wettability patterning enable combinatorial screening of stem cell behavior. Acta Biomaterialia 2016; 34: 93–103.

127. P. Dang, N. Dwivedi, X. Yu, L. Phillips, C. Bowerman, W.L. Murphy, E. Alsberg. Guiding chondrogenesis and osteogenesis with mineral-coated hydroxyapatite and BMP-2 incorporated within high-density hMSC aggregates for bone regeneration. ACS Biomaterials Science and Engineering. 2016; 2: 30–42.

128. A. Hanna, D. Thompson, D. Hellenbrand, J.S. Lee, C. Madura, M. Wesley, N. Dillon, T. Sharma, C. Enright, W.L. Murphy. Sustained release of neurotrophin-3 via calcium phosphate coated sutures promotes axonal regeneration after spinal cord injury. Journal of Neuroscience Research. 2016; 94: 645-52.

129. M.R. Zanotelli, H. Ardalani, J. Zhang, Z. Hou, E.H. Nguyen, S. Swanson, B.K. Nguyen, J. Bolin, A. Elwell, L. Bischel, A.W. Xie, R. Stewart, D.J. Beebe, J.A. Thomson, M.P. Schwartz, W.L. Murphy. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Acta Biomaterialia. 2016; 35: 32-41.

130. D.G. Belair, N.N.T. Le, W.L. Murphy. Regulating VEGF signaling in platelet concentrates via specific VEGF sequestering. Biomaterials Science. 2016; 4: 819-825.

131. D.G. Belair, M.J. Miller, S. Wang, S.R. Darjatmokon, N. Sheibani, W.L. Murphy. Differential regulation of angiogenesis using degradable VEGF-binding microspheres. Biomaterials, 2016; 93: 27-37.

132. J. Krutty, S.K. Schmitt, P. Gopalan, W.L. Murphy. Surface functionalization and dynamics of polymeric cell culture substrates. Current Opinion in Biotechnology. 2016; 40: 164-169.

133. X. Zhou, F. Moussa, N. Zhang, S. Magid, J. Molenda, W.L. Murphy, F. Safadi, N. Sahai. Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. Acta Biomaterialia, 2016; 39: 192-202.

134. D.G. Belair, M.P. Schwartz, T. Knudsen, W.L. Murphy. Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays. Acta Biomaterialia. 2016; 39: 12-24.

135. S. Verrier, M. Alini, E. Alsberg, S. Buchman, D. Kelly, M. Laschke, M. Menger, W.L. Murphy, C. Schutz, T. Miclau, M. Stoddart, C. Evans. Tissue engineering and regenerative approaches to improving the healing of large bone defects. eCM Journal, 2016; 32: 87-110.

136. S.J. Polak, J.S. Lee, W.L. Murphy, S. Tadier, L. Grémillard, I.V. Lightcap, A.J. Wagoner Johnson. Microstructural control of modular peptide release from microporous biphasic calcium phosphate. Materials Science and Engineering C. 2017; 72: 268-277.

137. M. Orth, N. Kruse, B. Braun, C. Scheuer, J.H. Holstein, A. Khalil, X. Yu, W.L. Murphy, T. Pohlemann, M.W. Laschke, M.D. Menger. BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions. eCM Journal. 2017; 33: 1-12.

138. E. Aktas, C.S. Chamberlain, E.E. Saether, S.E. Duenwald-Kuehl, J. Kondratko-Mittnacht, M. Stitgen, J.S. Lee, A.E. Clements, W.L. Murphy, R. Vanderby. Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect. Journal of Orthopedic Research. 2017; 35: 269-280.

139. Y. Zhu, T. Takayama, B. Wang, A. Kent, M. Zhang, B. Binder, G. Urabe, Y. Shi, D. DiRenzo, S. Goel, Y. Zhou, C. Little, D. Roenneburg, X. Shi, L. Li, W.L. Murphy, C. Kent, J. Ke, L.W. Guo. Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. Scientific Reports, 2017; 7: 41916.

140. J. Gershlak, S. Hernandez, G. Fontana, L. Perreault, K. Hansen, S. Larson, B. Binder, D. Dolivo, T. Yang, T. Dominko, M. Rolle, P. Weathers, F. Medina-Bolivar, C. Cramer, W.L. Murphy, G. Gaudette. Crossing kingdoms: using decellularized plants as perfusable tissue engineering scaffolds. Biomaterials, 2017; 125: 13-22.

141. X. Yu, J.S. Lee, A.J. Wagoner-Johnson, W.L. Murphy. Mineral binding peptides with enhanced binding stability in serum. Biomaterials Science, 2017, 5, 663–668.

142. M.C. Regier, S.I. Montanez-Sauri, M.P. Schwartz, W.L. Murphy, D.J. Beebe, K.E. Sung. The influence of biomaterials on cytokine production in 3D cultures. Biomacromolecules, 2017; 18: 709-718.

143. J. Zhang, Z. Hou, Y. Bai, H. Ardalani, S. Swanson, V. Ruotti, A. Elwell, B.K. Nguyen, J. Bolin, R. Stewart, J.A. Thomson, M.P. Schwartz, W.L. Murphy. A genome-wide analysis of vascular morphogenesis for human pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels compared to standard 2D or 3D culture platforms. Stem Cell Reports, 2017; 8: 907-918.

144. M. Parlato, J. Molenda, W.L. Murphy. Specific recruitment of circulating angiogenic cells using biomaterials as filters. Acta Biomaterialia. 2017; 56: 65-79.

145. P.N. Dang, S. Herberg, D. Varghai, H. Riazi, D. Varghai, A. McMillan, A. Awadallah, L.M. Phillips, O. Jeon, M.K. Nguyen, N. Dwivedi, X. Yu, W.L. Murphy, E. Alsberg. Endochondral ossification in critical-sized bone defects via readily implantable scaffold-free stem cell constructs. Stem Cells Translational Medicine. 2017; 6; 1644-1659.

146. J. Zhang, L.F. Chu, Z. Hou, M.P. Schwartz, T. Hacker, V.V. Kelley, S.A. Swanson, N. Leng, B.K. Nguyen, A. Elwell, J.M. Bolin, M. Brown, R. Stewart, W.J. Burlingham, W.L. Murphy, J.A. Thomson. Functional characterization of human pluripotent stem cell-derived arterial endothelial cells. Proceedings of the National Academy of Sciences, 2017; 114: E6072-E6078.

147. E. H. Nguyen, W.T. Daly, N.N. Le, D.G. Belair, M.P. Schwartz, C.S. Lebakken, G.E. Ananiev, M.A. Saghiri, T. Knudsen, N. Sheibani, W.L. Murphy. Versatile synthetic alternatives to matrigel for vascular toxicity screening and stem cell expansion. Nature Biomedical Engineering, 2017; 1: 0096.

148. A.W. Xie, B.Y.K. Binder, A.S. Khalil, S.K. Schmitt, H.J. Johnson, N.A. Zacharias, W.L. Murphy. Controlled self-assembly of stem cell aggregates instructs pluripotency and lineage bias. Scientific Reports, 2017; 7: 14070.

149. A.S. Khalil, X. Yu, A.W. Xie, G. Fontana, J. Umhoefer, T. Hookway , T.C. McDevitt, W.L. Murphy. Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells. Scientific Reports, 2017; 7: 14211.

150. C. Barry, MT Schmitz, N.E. Propson, Z. Hou, J. Zhang, B.K. Nguyen, J. Bolin, P. Jiang, B.E. McIntosh, M.D. Probasco, S. Swanson, R. Stewart, J.A. Thomson, M.P. Schwartz, W.L. Murphy. Uniform 3D vascularized neural tissues produced on synthetic hydrogels using standard culture techniques. Experimental Biology and Medicine, 2017; 242: 1679-1689.

151. C. Chamberlain, J. Jeffery, E. Leiferman, M.D. Tugrul, X. Sun, W.L. Murphy, G. Baer, R. Vanderby. Level-Specific Amputations and Resulting Regenerative Outcomes in the Mouse Distal Phalanx. Wound Repair and Regeneration, 2017; 25: 443-453.

152. X. Yu, A.H. Biedrzycki, A.S. Khalil, D. Hess, M.D. Markel, W.L. Murphy. Nanostructured mineral coatings stabilize proteins for therapeutic delivery. Advanced Materials, 2017; 29: 33.

153. G. Fontana, J. Gershlak, M. Adamski, J.S. Lee, S. Matsumoto, H.D. Le, B. Binder, J. Wirth, G. Gaudette, W.L. Murphy. Biofunctionalized plants as diverse biomaterials for human cell culture. Advanced Healthcare Materials, 2017; 6: 8.

154. A. Dias, J. Elicson, W.L. Murphy. Microcarriers with synthetic hydrogel surfaces for stem cell expansion. Advanced Healthcare Materials, 2017; 6: 16.

155. A.E. Clements, C.S. Chamberlain, E.M. Leiferman, W.L. Murphy, R. Vanderby. Impacts of Interleukin-17 neutralization on the inflammatory response in a healing ligament. Journal of Cytokine Biology, 2017; 2: 113.

156. N.J. Piscopo, K.P. Mueller, A. Das, P. Hematti, W.L. Murphy, S.P. Palecek, C.M. Capitini, K. Saha. Bioengineering solutions for manufacturing challenges in CAR T cells. Biotechnology Journal, 2018; 13(2).

157. A. McMillan, M.K. Nguyen, T. Gonzalez-Fernandez, P. Ge, X. Yu, W.L. Murphy, D.J. Kelly, E. Alsberg. Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering. Biomaterials, 2018; 161: 240-255.

158. J. Lei, W.L. Murphy, J.S. Temenoff. Combination of heparin binding peptide and heparin cell surface coatings for mesenchymal stem cell spheroid assembly. Bioconjugate Chemistry, 2018; 29: 878-884.

159. M. Adamski, G. Fontana, J.R. Gershlak, G.R. Gaudette, H.D. Le, W.L. Murphy. Two methods for decellularization of plant tissues for tissue engineering applications. Journal of Visualized Experiments, 2018; 135.

160. A.E. Clements, C.S. Chamberlain, R. Vanderby, W.L. Murphy. Microparticles locally deliver active interleukin-1 receptor antagonist in vivo. Advanced Healthcare Materials, 2018;7: e1800263.

161. E.H. Nguyen, W.L. Murphy. Customizable biomaterials as tools for advanced anti-angiogenic drug discovery. Biomaterials, 2018; 181: 53-66.

162. A.E. Clements, C.S. Chamberlain, R. Vanderby, W.L. Murphy. Addition of mineral coated microparticles to soluble interleukin-1 receptor antagonist injected subcutaneously improves and extends systemic interleukin-1 inhibition. Advanced Therapeutics, 2018; 1: 1800048.

163. S.W. Bae, J.S. Lee, W.L. Murphy. Dynamic, bioresponsive hydrogels via changes in DNA aptamer conformation. Macromolecular Bioscience, 2019; 19: e1800353.

164. J. Krutty, W.L. Murphy, P. Gopalan. Synthetic, chemically-defined polymer-coated microcarriers for the expansion of human mesenchymal stem cells. Macromolecular Bioscience, 2019; 19: e1800299.

165. G. Kaushik, D.A. Gil, E. Torr, E.S. Berge, C. Soref, P. Uhl, G. Fontana, J. Antosiewicz-Bourget, C. Edington, M.P. Schwartz, L.G. Griffith, J.A. Thomson, M.C. Skala, W.T. Daly, W.L. Murphy. Quantitative label-free imaging of three-dimensional vascular networks self-assembled in synthetic hydrogels. Advanced Healthcare Materials, 2019; 8: e1801186.

166. A.W. Xie, W.L. Murphy. Engineered biomaterials to mitigate growth factor cost in cell biomanufacturing. Current Opinion in Biomedical Engineering, 2019; 10: 1-10.

167. M. Orth, A.K. Shenar, C. Scheuer, B.J. Braun, S.C. Herath, J.H. Holstein, T. Histing, X. Yu, W.L. Murphy, T. Pohlemann, M.W. Laschke, M.D. Menger. VEGF-loaded mineral coated microparticles improve bone repair and are associated with increased expression of EPO and RUNX-2 in murine non-unions. Journal of Orthopedic Research, 2019; 37: 821-831.

168. B. Kerzner, H.L. Martin, M. Weiser, G. Fontana, N. Russell, W.L. Murphy, E.A. Lund, C.J. Doro. A reliable and reproducible critical-sized segmental femoral defect model in rats stabilized with a custom external fixator. Journal of Visualized Experiments, 2019; 24; 145.

169. D.J. Hellenbrand, K.A. Reichl, B.J. Travis, M.E. Filipp, A.S. Khalil, D.J. Pulito, A. Gavigan, E.R. Maginot, M.T. Arnold, A.G. Adler, W.L. Murphy. A.S. Hanna. Sustained interleukin-10 delivery reduced inflammation and improves motor function after spinal cord injury. Journal of Neuroinflammation, 2019; 16: 93.

170. E.H. Nguyen, M.L.J. Dombroe, D.L. Fisk, W.T. Daly, C.M. Sorenson, W.L. Murphy, N. Sheibani. Neurovascular organotypic culture models using induced pluripotent stem cells to assess adverse chemical exposure outcomes. Applied In Vitro Toxicology, 2019; 5: 92-110.

171. A.S. Khalil, X. Yu, P. Dang, E. Alsberg, W.L. Murphy. A microparticle approach for non-viral gene delivery within 3D human mesenchymal stromal cell aggregates. Acta Biomaterialia, 2019; 95: 408-417.

172. A.E. Clements, W.L. Murphy. Injectable biomaterials for delivery of interleukin-1 receptor antagonist: toward improving its therapeutic effect, Acta Biomaterialia, 2019; 93: 123-134.

173. S.G. Mina, B. Alaybeyoglu, W.L. Murphy, J.A. Thomson, C.L. Stokes, M. Cirit. Assessment of drug-induced toxicity biomarkers in the brain microphysiological system (MPS) using targeted and untargeted molecular profiling. Frontiers in Big Data, 2019; 2: 23.

174. H. Ardalani, S. Sengupta, V. Vickerman Kelley, J.A. Thomson, W.L. Murphy. 3-D culture and sinusoidal endothelial cells improve maturity of human pluripotent stem cell-derived hepatocytes. Acta Biomaterialia, 2019; 95: 371-381

175. G. Fontana, H.L. Martin, J.S. Lee, K. Schill, P. Hematti, W.L. Murphy. Mineral-coated microparticles enhance mRNA-based transfection of human bone marrow cells. Molecular Therapy – Nucleic Acids, 2019; 18 :455-464.

176. M.K. Livingston, M.M. Morgan, W.T. Daly, W.L. Murphy, B.P. Johnson, D.J. Beebe, M. Virumbrales-Munoz. Evaluation of PEG-based hydrogel influence on estrogen-receptor-driven responses in MCF7 breast cancer cells. ACS Biomaterials Science and Engineering, 2019; 5: 6089-6098.

177. N.N.T. Le, T.L. Liu, J. Johnston, K.M. Templeton, V. Harms, A. Dias, J. Krutty, H. Lef, P. Gopalan, W.L. Murphy. Customized hydrogel substrates for serum-free expansion of functional hMSCs. Biomaterials Science, 2020; 8: 3819 - 3829.

178. E. Aisenbrey, W.L. Murphy. Synthetic alternatives to Matrigel. Nature Reviews Materials, 2020; 5: 539-551.

179. A.S. Khalil, A.W. Xie, H. Johnson, W.L. Murphy. Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion. Biomaterials, 2020; 248: 120007.

180. A.S. Khalil, X.Yu, J.M. Umhoefer, G.M. Diarrad, T.A. Hacker, W.L. Murphy. Single dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins. Science Advances, 2020; 6: eaba2422.

181. G. Kaushik, K. Gupta, V. Harms, E. Torr, J. Evans, H.J. Johnson, C. Soref, S. Acevedo-Acevedo, J. Antosiewicz-Bourget, D. Mamott, P. Uhl, B.P. Johnson, S.P. Palecek, D.J. Beebe, J.A. Thomson, W.T. Daly, W.L. Murphy. Engineered perineural vascular plexus for modeling developmental toxicity. Advanced Healthcare Materials, 2020;9:e2000825.

182. D. Hellenbrand, C. Haldeman, J.S. Lee, A. Gableman, E. Dai, S. Ortmann, J. Gotchy, K. Miller, A. Doucas, N. Nowak, W.L. Murphy, A. Hanna. Improving function after nerve injury via sustained growth factor delivery from mineral coated microparticles. Neural Regeneration Research, Accepted.

183. A.W. Xie, N.A. Zacharias, W.L. Murphy. Controlled aggregation enhances immunomodulatory potential of mesenchymal stromal cell aggregates. Stem Cells Translational Medicine, Accepted.

Books:

1. G.A. Hudalla and W.L. Murphy Eds.. Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials. Royal Society of Chemistry, 2015.

2. W.L. Murphy Ed. Handbook of Biomaterial Properties. Springer, 2016.

Chapters in Conference Proceedings/Preprints:

1. W.L. Murphy, K.A. Gilhool, D.H. Kohn, D.J. Mooney. Effects of growth factor presence on mineralization of porous poly(lactide-co-glycolide) scaffolds in vitro. In: Mineralization in Natural and Synthetic Biomaterials, Materials Research Society. P. Li, P. Calvert, R.J. Levy, T. Kokubo, C.R. Schneid, Eds., 1999.

2. G.C. Spalding, W.L. Murphy, T.M. Davidsmeier, J.E. Elenewski. Faceting of the (100) face of single-crystal SrTiO3 during wet chemical etching. In: Substrate Engineering: Paving the Way to Epitaxy, D.P. Norton, D.G. Schlom, N. Newman, D.H. Matthies, Eds., Materials Research Society, 1999.

3. W.L. Murphy, K.A. Gilhool, D.J. Mooney. Biomineralization via bioinspired variation in polymer surface chemistry. PMSE Preprints, American Chemical Society, Fall, 2001.

4. W.L. Murphy, C.A. Simmons, D.J. Mooney. A combination approach to engineering bone regeneration: biomineral presentation and induced angiogenesis. Proceedings of the EMBS-BMES conference, 2002, Vol. 3, p. 886-887, 2002.

5. G.A. Hudalla, W.L. Murphy. Non-covalent assembly of peptide-growth factor complexes to spatially control cell activity. PMSE Preprints, American Chemical Society, Spring, 2007.

6. Z. Sui, W.J. King, W.L. Murphy. Influence of network parameters on the properties of dynamic, protein-based hydrogels. PMSE Preprints, American Chemical Society, Fall, 2007.

7. G.A. Hudalla, W.L. Murphy. Using non-covalent interactions to modulate local soluble signaling. PMSE Preprints, American Chemical Society, Spring, 2008.

8. W.L. Murphy. Temporal and spatial control over soluble protein signaling for musculoskeletal tissue engineering, Proceedings of the IEEE-EMBS conference, 2009.

9. N.A. Shah, T. Franklin-Ford, K. Vigen, C. Hatt, W.L. Murphy, A. Raval. Precise tracking of novel sustained release angiogenic peptide-linked microspheres in a swine myocardial infarction model. Journal of the American College of Cardiology. 2013; 57: E1519.

10. J.S. Lee, R.T. Hill, A Chilkoti, W.L. Murphy. Surface Patterning. Biomaterials Science. 2020.

Patents:

1. W.L. Murphy, M.T. Dearing, G.C. Spalding, D.J. Mooney, D.H. Kohn. Mineral and cellular patterning on biomaterial surfaces. U.S. Patent 6,541,022.

2. W.L. Murphy, M.C. Peters, D.J. Mooney, D.H. Kohn. Mineralization and biological modification of biomaterial surfaces. U.S. Patent 6,767,928.

3. W.L. Murphy, R.G. Dennis, D.J. Mooney. Tissue engineering scaffolds. U.S. Patent 7,575,759.

4. W.L. Murphy, J.S. Lee, M. Markel, B. Graf. Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery. U.S. Patent 8,075,562.

5. W.L. Murphy, S. Choi. Method and system for delivery of a nucleic acid into a target cell. U.S. Patent 8,187,883.

6. C.Y. Lin, F. LaMarca, S. Feinberg, W.L. Murphy, J. Adox, S.J. Hollister. Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration. U.S. Patent US 8,275,594.

7. W.L. Murphy, G. Hudalla. Spatial control of signal transduction. U.S. Patent 8,389,009.

8. W.L. Murphy, J.S. Lee, J.S. Lee, M. Markel, B. Graf. Decorating hydroxyapatite biomaterials with modular, biologically active molecules. U.S. Patent 8,420,774.

9. W.L. Murphy, M. Markel, B.K. Graf, Y. Lu, J.S. Lee. Tissue regeneration system. U.S. Patent 8,778,869.

10. W.L. Murphy, J.T. Koepsel. Chemically-defined arrays for screening cell-substrate interactions. U.S. Patent No. 8,642,516.

11. W.L. Murphy, J.S. Lee, M. Markel, B. Graf. Methods of decorating hydroxyapatite biomaterials with modular, biologically active molecules. U.S. Patent 8,846,860.

12. W.L. Murphy, M.C. Peters, D.J. Mooney, D.H. Kohn. Mineralization and biological modification of biomaterial surfaces. U.S. Patent 9,072,813.

13. W.L. Murphy. Multilayer tissue regeneration system. U.S. Patent 9,295,755.

14. C.Y. Lin, F. LaMarca, W.L. Murphy, S.J. Hollister. Degradable cage coated with mineral layers for spinal interbody fusion. U.S. Patent 9,439,948.

15. J.S. Lee, M. Markel, B. Graf, G. Baer, Y. Lu, W.L. Murphy, Biologically active sutures for regenerative medicine. U.S. Patent 9,636,109.

16. W.L. Murphy, M. Schwartz, M. Parlato, N.N. Le. Hydrogel compositions for use in cell expansion and differentiation. U.S. Patent 9,683,213.

17. W.L. Murphy, E. Nguyen, M. Schwartz, H. Ardalani, M. Zanotelli, M. Parlato, D. Belair, W. Daly, N.N. Le. Hydrogel compositions for use in promoting tubulogenesis. U.S. Patent 9,688,957.

18. W.L. Murphy, N.N. Le. Covalently-immobilized hydrogel arrays in multi-well plates. U.S. Patent 9,694,338.

19. P. Gopalan, W.L. Murphy, S.K. Schmitt. Azlactone based thermally crosslinkable polymer coating for controlling cell behavior. U.S. Patent 9,777,185.

20. W.L. Murphy, S. Choi, X. Yu. Enhanced throughput mineral coatings for optimization of stem cell behavior. U.S. Patent 9,951,374.

21. W.L. Murphy, S. Choi, X. Yu. Enhanced throughput mineral coatings for optimization of stem cell behavior. U.S. Patent 10,745,739.

22. D.G. Belair, N.N. Le, M.W. Toepke, N. Impellitteri, C.S. Chamberlain, W.L. Murphy. Hydrogel spheres containing peptide ligands for growth factor regulation in blood products. U.S. Patent 10,183,079.

23. J.A. Thomson, N.E. Propson, M.P. Schwartz, Z. Hou, G.I. Uenishi, I.I. Slukvin, W.L. Murphy, J. Zhang. Derivation of human microglia from pluripotent stem cells. U.S. Patent 10,081,792.

24. N.N. Le, S. Zorn, W.T. Daly, M.P. Schwartz, E.H. Nguyen, W.L. Murphy. Method for forming hydrogel arrays using surfaces with differential wettability. U.S. Patent 10,195,313.

25. A.W. Xie, W.L. Murphy. Chemically labile peptide-presenting surfaces for cellular self-assembly. Claims Allowed.

26. P. Gopalan, W.L. Murphy, S.K. Schmitt. Azlactone based thermally crosslinkable polymer coating for controlling cell behavior. Claims Allowed.

27. L. Jongpaiboonkit, W.L. Murphy. Mineral-coated microspheres. Patent Application filed, 2008.

28. G. Hudalla, W.L. Murphy. Proteoglycan-binding peptides that modulate stem cell behavior. Patent Application filed, 2009.

29. W.L. Murphy, R. Vanderby, G. Baer, B. Graf, J.S. Lee, C. Chamberlain. Medical device coatings that bind and deliver blood components. Patent Application filed, 2011.

30. S.J. Hollister, S.J. Feinberg, W.L. Murphy, L. Jongpaiboonkit, J.R. Adox, F. Migneco. Modular tissue scaffolds. Patent Application filed, 2012.

31. W.L. Murphy, S. Lan Levengood, S. Brounts. Modular, bioactive peptide binds to bone and improves bone graft osteoinductivity. Patent Application filed, 2012.

32. W.L. Murphy, S. Lan Levengood, J.T. Koepsel, S. Zorn. Substrates for generation of controlled human pluripotent stem cell colony size and shape. Patent Application filed, 2014.

33. L. Jongpaiboonkit, W.L. Murphy. Custom coatings on orthopedic implants. Patent Application filed, 2014.

34. J.A. Thomson, W.L. Murphy, C.D. Page, M.P. Schwartz, Z. Hou. Human pluripotent stem cell-based models for predictive developmental neural toxicity. Patent Application filed, 2014.

35. L. Guo, X. Yu, W.L. Murphy, C. Kent. Perivascular delivery system and method. Patent Application filed, 2014.

36. L. Jongpaiboonkit, W.L. Murphy. Mineral-coated Scaffolds. Patent Application filed, 2015.

37. L. Jongpaiboonkit, W.L. Murphy. Coating scaffolds. Patent Application filed, 2015.

38. A.S. Khalil, X. Yu, K. Saha, J. Carlson-Stevermer, B. Steyer, W.L. Murphy. Inorganic coatings for the enhancement of chemical transfection. Patent Application filed, 2015.

39. J. Lei, W.L. Murphy, J.S. Temenoff. Development of HEPpep and heparin coatings for MSC spheroid microtissue assembly. Patent Application filed, 2016.

40. D.G. Belair, N.N. Le, A. Kellner, W.L. Murphy. TGF-β1-binding peptides and hydrogel microspheres containing the peptides for growth factor regulation in blood products. Patent Application filed, 2016.

41. J. Gershlak, G. Gaudette, P. Weathers, T. Dominko, M. Rolle, S. Hernandez, W.L. Murphy, C. Cramer, Fabricio Medina-Bolivar. Decellularization of plant tissues. Patent Application filed, 2016.

42. W.L. Murphy, G. Fontana. Functionalization of plant tissues for human cell expansion. Patent Application filed, 2017.

43. A.S. Khalil, C. Lebakken, W.L. Murphy. Visible light polymerization of PEG hydrogels. Patent Application filed, 2017.

44. A. Clements, C. Chamberlain, R. Vanderby Jr., W.L. Murphy. Mineral coated microparticles for sustained delivery of biologically active molecules. Patent Application filed, 2017.

45. A.S. Khalil, X. Yu, W.L. Murphy. Mineral-coated microparticles for the co-delivery of anti-inflammatory molecules with nucleic acids to improve gene delivery outcomes. Patent Application filed, 2017.

46. A.S. Khalil, X. Yu, W.L. Murphy. Mineral-coated microparticles for gene delivery in chronic wound therapy. Patent Application filed, 2017.

47. L. Jongpaiboonkit, W.L. Murphy. Osteostimulatory mineral coatings that reduce bacterial adhesion. Patent Application filed, 2017.

48. W.L. Murphy, A.S. Khalil, A.W. Xie, Hunter Johnson. Structured nanocoatings for the stabilization of pluripotent stem cell media components. Patent Application filed, 2018.

49. G. Fontana, A.S. Khalil, J.S. Lee, W.L. Murphy. Delivery of biologics via mineral nanocrystals for regenerative medicine applications. Patent Application filed, 2018.

50. W.T. Daly, C. Soref, W.L. Murphy. A chemically defined differentiation protocol for pericyte differentiation from pluripotent stem cells. Patent Application filed, 2018.

51. A.E. Clements, W.L. Murphy, B. Kurokawa. Mineral-coated microparticles for sustained delivery of steroids. Patent Application filed, 2018.

52. W.T. Daly, Jonathan Evans, Elizabeth Aisenbrey, Elizabeth Torr, W.L. Murphy. Hydrogel compositions for use in neural cell expansion and differentiation. Patent Application filed, 2018.

53. W.L. Murphy, E. Aisenbrey, E. Torr, V. Harms. iPSC-derived brain organoids for cancer modeling and drug screening. Patent Application filed, 2019.

54. A. Clements, W. Murphy. Enhanced delivery of conditioned serum using mineral coated microparticles. Patent application filed, 2019.

55. G. Gaudette, K. Barteau, G. Fontana, M. Suzuki, W.L. Murphy. Plant-derived scaffolds to support the generation of synthetic meat. Patent application filed, 2019.

56. A. Clements, M. Ostrowski, W.L. Murphy. Enhanced delivery of conditioned serum using mineral coated microparticles. Patent application filed, 2020.

57. A. Clements, M. Ostrowski, W.L. Murphy. Methods for treating or preventing inflammatory events. Patent application filed, 2020.

Invited Presentations

1. Development of synthetic, biomimetic extracellular matrices, University of Illinois, Chemical and Biomolecular Engineering Seminar, Spring, 2004. (Faculty interview)

2. Development of synthetic, biomimetic extracellular matrices, University of Pennsylvania, Bioengineering Seminar, Spring, 2004. (Faculty Interview)

3. Development of synthetic, biomimetic extracellular matrices, Northwestern University, Biomedical Engineering Seminar, Spring, 2004. (Faculty Interview)

4. Development of synthetic, biomimetic extracellular matrices, Purdue University, Biomedical Engineering Seminar, Spring, 2004. (Faculty Interview)

5. Development of synthetic, biomimetic extracellular matrices, University of Wisconsin, Biomedical Engineering Seminar, Spring, 2004. (Faculty Interview)

6. Development of synthetic, biomimetic extracellular matrices, University of Colorado, Chemical and Biological Engineering Seminar, Spring, 2004. (Faculty Interview)

7. Development of synthetic, biomimetic materials, University of Illinois at Chicago, Bioengineering Seminar, Spring, 2004.

8. Toward mimicry of natural tissue development: using smart materials to instruct stem cells, Wisconsin Engineers Day Colloquium, Fall, 2005.

9. Using non-covalent interactions to modulate local soluble signaling. Symposium on: “Designed Macromolecular Assemblies for Biomedical Applications”, American Chemical Society Conference, Chicago, IL, Spring, 2007.

10. Assembly of Biomaterials for Regenerative Medicine, University of Illinois, Mechanical Science and Engineering Seminar, Spring, 2007.

11. Using materials science to modulate microenvironments in biology, Wisconsin Stem Cell and Regenerative Medicine Symposium, 2007.

12. Dynamic materials based on a nanoscale protein conformational change. Symposium on “Self-Assembling Biomaterials”, Society for Biomaterials Conference, Chicago, IL, 2007.

13. Bio-inspired assembly of materials for tissue engineering, Genzyme Tissue Engineering Mini-Symposium, Fall, 2007.

14. Protein-based hydrogels with tunable dynamic responses. Symposium on: “Stimulus-Responsive Materials”, Materials Research Society Conference, San Francisco, CA, Spring, 2008.

15. Using non-covalent interactions to design biologically active materials. Symposium on “Controlling Cell Functions Through Polymer Synthesis and Engineering”, American Chemical Society Conference, New Orleans, LA, Spring, 2008.

16. Bioinspired design of functional materials. University of Washington, Nanotechnology Program Seminar, Spring, 2008.

17. Bio-inspired assembly of functional materials, Rice University, Bioengineering Seminar, Spring, 2008.

18. Emerging approaches for stem cell-based tissue engineering, Northwestern University, Biotechnology Program Seminar, Spring, 2008.

19. Bio-inspired assembly of functional materials, Northwestern University, Biomedical Engineering Seminar, Spring, 2008.

20. Emerging approaches for stem cell-based tissue engineering, Discussions on Advancing Regenerative Technologies (DART), 2008. (Available via web at ).

21. Using bioinspired materials to regulate stem cell behavior. 1st annual Wisconsin Stem Cell Technology Symposium, Madison, WI, Fall, 2008.

22. Promoting local stem cell differentiation using engineered, modular growth factors. Symposium on “Stem Cell based Tissue Engineering”, American Chemical Society Conference, Philadelphia, PA, Fall, 2008. (Selected for inclusion in “Best of BIOT” webinar series as top presentation in session)

23. Novel growth factor delivery strategies for lone bone healing. 2nd International Symposium on Biotechnology in Musculoskeletal Repair, Lausanne, Switzerland, Fall 2008.

24. Bio-inspired assembly of functional materials. Ecole Polytechnique Federale de Lausanne Institute of Bioengineering, Lausanne, Switzerland, Fall 2008.

25. Promoting local stem cell differentiation using engineered, modular growth factors. American Chemical Society “Best of BIOT” webinar symposium Stem Cell Based Tissue Engineering, Spring, 2009.

26. Inductive biomaterials for orthopedic tissue regeneration. Symposium on “Regenerative Technologies in Orthopedic Surgery”, The Design of Medical Devices Conference, Minneapolis, MN, Spring, 2009.

27. Inductive biomaterials for tissue regeneration. University of Michigan, Department of Biomedical Engineering Seminar, Ann Arbor, MI, Spring, 2009.

28. Bioinspired design of functional materials. Northwestern University, Chemical and Biological Engineering Seminar, Spring, 2009.

29. Dynamic, protein-based materials for controlled release. Symposium on “Hydrogels: from nanoparticulate drug carriers to scaffolds for tissue engineering”, Controlled Release Society Conference, Copenhagen, Denmark, Spring, 2009.

30. Dynamic, protein-based materials for controlled release and biosensing. Symposium on: “Actuator and Simuli-Responsive Polymeric Materials and Composites”, American Chemical Society Conference, Washington, D.C., Summer 2009.

31. Temporal and spatial control over soluble protein signaling for musculoskeletal tissue engineering. Symposium on: “Tissue Engineering”, IEEE Engineering in Medicine and Biology Society Conference, Minneapolis, MN, Summer 2009.

32. “Smart” biomaterials inspired by nature’s mechanisms. Georgia Institute of Technology, Bioengineering Seminar, 2009.

33. Bioinspired materials that regulate growth factor signaling and stem cell behavior. Symposium on “Engineering Biomaterials for Regenerative Medicine”, Materials Research Society Conference, Fall, 2009.

34. Smart Biomaterials (Keynote Presentation), Biomaterials – Africa Conference, Pretoria, South Africa, Fall, 2009.

35. Novel growth factor delivery strategies for bone healing. AO Research Foundation Large Bone Defect Healing Symposium, Davos, Switzerland, Fall 2009.

36. Drug delivery strategies for craniofacial tissue regeneration. University of Michigan Craniofacial Regenerative Medicine Symposium, Fall, 2009.

37. Functional biomaterials that regulate growth factor signaling, University College-London, Bioengineering Seminar, Spring, 2010.

38. Functional biomaterials that regulate growth factor signaling (Keynote Presentation). Polymer Biomaterials Conference, Reading, UK, Spring, 2010.

39. Biomaterials that mimic and exploit biology. Imperial College, Department of Materials Seminar, London, UK, Spring, 2010.

40. Assembly of signaling molecules in the cellular microenvironment. Foundations of Nanoscience Conference, Snowbird, UT, Spring, 2010.

41. Inductive biomaterials for tissue regeneration. University of Chicago, Department of Surgery Seminar, Chicago, IL, Spring, 2010.

42. Novel approaches for protein and gene delivery. AO Large Bone Defect Healing Symposium, Harvard Medical School, Boston, MA, Fall, 2010.

43. Mimicking ECM regulation of growth factor signaling (Keynote Presentation). Matrix Biology and Tissue Engineering Workshop, Charleston, South Carolina, Fall, 2010.

44. Regulating growth factor signaling via non-covalent sequestering. Regenerative Medicine: Innovations for Clinical Applications Workshop, Hilton Head, SC, Spring, 2011.

45. Regulating stem cell behavior via non-covalent molecular sequestering. Symposium on “Polymers for Molecular Recognition”, American Chemical Society Conference, Anaheim, CA, Spring 2011.

46. Bioinspired engineering. Frontiers of Engineering Symposium, National Academy of Engineering, San Diego, CA, Spring 2011.

47. Modular ECM-binding growth factors for stem cell differentiation and tissue engineering, Materials Research Society Conference, San Francisco, CA, Spring 2011.

48. Synthetic Biomaterials, in “Cagematch 2011: Natural vs. Synthetic Biomaterials”, Society for Biomaterials Conference, Orlando, FL, Spring 2011.

49. Biomimetic stem cell culture: toward mimicking natural microenvironments. Bioengineering Seminar, University of California-Berkeley, Spring, 2011.

50. Progress toward using stem cells to make tissues. Wednesday Night at the Lab, Biotechnology Center, Madison, WI, Fall, 2011.

51. Novel approaches for protein and gene delivery. AO Large Bone Defect Healing Symposium, AO Research Institute, Davos, Switzerland, Fall, 2011.

52. Bioinspired hydrogels: toward mimicking natural microenvironments, AIChE Conference, Minneapolis, MN, Fall, 2011.

53. Biomimetic stem cell culture: toward mimicking natural microenvironments. In: Biomaterials for Stem Cell Expansion and Differentiation, AIChE Conference, Minneapolis, MN, Fall, 2011.

54. Materials that mimic and harness biological signals, Biomaterials Days Symposium, Purdue University, Fall, 2011 (Keynote Presentation).

55. Inductive biomaterials for tissue regeneration. Washington University, Department of Orthopedic Surgery Seminar, St. Louis, MO, Fall, 2011.

56. Materials that mimic and harness biological signals, Biomedical Engineering Seminar, Texas A&M University, Fall, 2011.

57. Materials that mimic and harness biological signals. Chemical and Biological Engineering Seminar, University of Colorado, Spring, 2012.

58. Materials that mimic and harness biological signals, Polymers and Advanced Materials Seminar, University of Akron, Spring, 2012.

59. Harnessing endogenous signals in the stem cell microenvironment. SBE’s International Conference on Stem Cell Engineering, Seattle, WA, Spring, 2012.

60. Chemically defined biomaterials for stem cell biology. Developmental Biology Research Seminar. Washington University, Spring, 2012.

61. Using biomaterials to regulate angiogenesis. Cardiovascular Research Seminar, Emory University, Spring, 2012.

62. Engineering Tissue Function. Signal Transduction via Engineered Extracellular Matrices, Gordon Research Conference, Summer, 2012.

63. Cell-Material Interactions. NSF Workshop on Biomaterials, Summer, 2012.

64. Probing and manipulating mesenchymal stem cell behavior in defined microenvironments. In: Controlling Adult Stem Cells, Society for Biomaterials Conference, New Orleans, LA, Fall, 2012.

65. Orthopedic biomaterials that mimic and harness biological signals, Musculoskeletal Research Seminar, University of Pennsylvania, Philadelphia, PA, 2012.

66. Biomaterials that mimic and harness biology. Physics Colloquium in honor of Narendra Jaggi, Illinois Wesleyan University, Bloomington, IL, 2012. (Keynote presentation)

67. Synthetic hydrogels for vascular morphogenesis. Bioengineering Seminar, Massachusetts Institute of Technology, Cambridge, MA, 2012.

68. Biomaterials that mimic and harness biology. Sigma Aldrich Research Seminar, Milwaukee, WI, 2012.

69. Bioinspired molecular sequestering in the stem cell environment. Stem Cell Engineering Center Seminar Series, Georgia Institute of Technology, Atlanta, GA, Spring, 2013.

70. Bioinspired molecular sequestering in the stem cell microenvironment. American Chemical Society Conference, New Orleans, LA, Spring, 2013.

71. Stem cell engineering: Progress and promise. UW Founders Day Event, Atlanta, GA, Spring, 2013.

72. Optimizing ‘give and take’ between stem cells and materials. NSF workshop on new directions in tissue engineering and regenerative medicine, Napa, CA, 2013.

73. Human induced pluripotent stem cell and embryonic stem cell-based models for predictive neural toxicity. NIH Microphysiological Systems Program investigators’ meeting. Bethesda, MD, 2013.

74. Vascular Tissue Engineering Using Human iPS-derived Cells. CDI Users Group Meeting, Madison, WI, Fall 2013.

75. Bioinspired affinity interactions: toward regulating tissue regeneration. NanoDDS Conference, San Diego, CA, Fall, 2013.

76. Biomaterials regulation of morphogen presentation. TERMIS Americas Conference, Atlanta, GA, Fall, 2013.

77. Optimized coatings for tissue regeneration. Regeneration is communication: fireside chats between cells and matrices symposium, Berlin Brandenburg School for Regenerative Therapies (BSRT), Berlin, Germany, Fall, 2013.

78. Engineered human vasculature for drug and toxin screening. FutureTox II: Pathways to Prediction Contemporary Concepts in Toxicology, Chapel Hill, NC, Spring 2014.

79. Coated orthopedic devices for tissue regeneration. Athletic Training Physician Extender Residency Workshop. San Diego, CA, Spring 2014.

80. Biologically Driven Assembly of Human Tissues in Synthetic Environments. Stem Cell Engineering Conference, San Diego, CA, Spring 2014.

81. Optimized coatings for tissue regeneration. Functional biomaterials for regenerative engineering symposium, Materials Research Society Conference, San Francisco, CA, Spring, 2014.

82. Materials that mimic and harness biological signals. 3M Research Seminar, St. Paul, MN, Spring, 2014.

83. Biomaterials as the accelerator, the clutch, and the brakes in stem cell culture. Gordon Research Conference on “Signal Transduction by Engineered Extracellular Matrices”, Boston, MA, Summer, 2014.

84. Using biomaterials to regulate angiogenesis. Surgery Department End of Year Keynote Seminar, University of Wisconsin, Spring, 2014.

85. Toward design rules for human tissue assembly. Emerging technologies in regenerative medicine workshop, Los Angeles, CA, Fall, 2014.

86. The role of patents in inventive work. Thomas Edison Innovation Fellowship Conference, Scottsdale, AZ, Fall, 2014.

87. Synthetic materials for biologically driven assembly of human tissues. Design rules for protein and peptide self-assembly symposium. Materials Research Society Conference, San Francisco, CA, Spring, 2015.

88. Human induced pluripotent stem cell and embryonic stem cell-based models for predictive neural toxicity. NIH Microphysiological Systems Program investigators’ meeting. Arlington, VA, Spring, 2015.

89. Toward human models for analysis of pathways. Microphysiological models of the developing nervous system symposium. Society of Toxicology Conference, San Diego, CA, Spring, 2015.

90. Toward human tissue models via human tissue assembly. Children’s Research Institute Seminar, Medical College of Wisconsin, Milwaukee, WI, Spring, 2015.

91. Modular tools to regenerate musculoskeletal tissues. World Stem Cell Summit, San Antonio, TX, Spring, 2015.

92. Musculoskeletal regeneration. 15th Annual Primary Care Orthopaedics & Sports Medicine Symposium, Wausau, WI, Spring, 2015.

93. Optimized mineral coatings for tissue regeneration. Biomedical Engineering Seminar, Duke University, Raleigh, NC, Spring, 2015.

94. Customized scaffolding for skeletal tissue regeneration. Wisconsin Stem Cell Symposium, BTCI/Promega, Fitchburg, WI, Spring, 2015.

95. Customized device coatings for musculoskeletal regeneration. National Research Council of the National Academies of Science and Engineering and the Institute of Medicine BEMA Roundtable, Washington D.C., Spring, 2015.

96. Toward organotypic models via human tissue assembly. Inaugural Speaker, Regenerative Medicine Initiative, Vanderbilt University, Summer 2015.

97. Customized biomaterials for musculoskeletal regeneration. Vail Scientific Summit, Vail, CO, Fall 2015.

98. Human pluripotent stem cell-derived neural tissue models for predictive neurotoxicity screening and safety assessment. NIH Microphysiological Systems Program investigators’ meeting. Bethesda, MD, Spring, 2015.

99. Assembly of stem cell-derived human tissues for high throughput screening applications. TERMIS World Congress, Boston, MA, Fall 2015.

100. Assembly of stem cell-derived human tissues for high throughput screening applications. iForum, Conference, Chicago, IL, Fall 2015.

101. Assembly of stem cell-derived human tissues for high throughput screening applications. Thermo Fisher Scientific Seminar, Madison, WI, Fall 2015.

102. Assembly of stem cell-derived human tissues for high throughput screening applications. 24 Hours of Stem Cells, Webcast, Fall 2015.

103. Biomaterials for assembly of stem cell-derived human tissues. Biomaterials Day, Madison, WI, Fall 2015.

104. Customized biomaterials for musculoskeletal regeneration. World Stem Cell Summit, Atlanta, GA, Fall 2015.

105. Human pluripotent stem cell-derived neural tissue models for neurotoxicity screening. World Biomaterials Congress, Montreal, Canada, Summer 2016.

106. Stem cells and regenerative medicine. Wisconsin Technology Council luncheon, Madison, WI. Summer 2016.

107. Engineered microphysiological systems for cell-based predictive models of developmental neurotoxicity. Teratology Society Conference, San Antonio, TX, Summer 2016.

108. Toward design rules for bioinspired assembly of human tissues. Gordon Research Conference on Bioinspired Materials. Switzerland, Summer 2016.

109. Customized biomaterials for musculoskeletal regeneration. Simpson Querrey Institute Seminar, Northwestern University, Summer 2016.

110. Leveraging autologous cells and tissues for regenerative medicine. Vail Scientific Symposium, Vail, CO, Summer 2016.

111. Wisconsin: a biomanufacturing center of excellence. Wisconsin BioHealth Summit, Madison, WI. Fall 2016.

112. Customized biomaterials for cell and tissue therapy. Crossing Boundaries to Propel Tissue Engineering into the Clinic Symposium, Stanford University, Fall 2016.

113. Reproducible assembly of neural organoids for screening applications. Society for Neuroscience Conference, San Diego, CA, Fall 2016.

114. Assembly of human tissues for screening applications. Regenerative Medicine Workshop, Hilton Head, SC, Spring 2017.

115. Assembly of human tissues for screening applications. Stem Cell and Regenerative Medicine Center Seminar Series, Madison, WI, Spring 2017.

116. Reproducible assembly of human tissues on a chip for screening applications. Experimental Biology conference, Chicago, IL, Spring 2017.

117. Assembly of human tissues for screening applications. Institute for Genomic Biology seminar series, Champaign, IL, Spring 2017.

118. Bioinspired approaches for musculoskeletal protein and gene delivery. Musculoskeletal Regenerative Medicine and Biology Symposium, Washington University, St. Louis, MO, Spring 2017.

119. Assembly of human tissues for screening applications. AIMBE/NIH Workshop on Validation and Qualification of New In Vitro Tools and Models for the Pre-Clinical Drug Discovery Process. Bethesda, MD, Spring 2017.

120. Wisconsin: a biomanufacturing center of excellence. BMES Advanced Biomanufacturing Conference, Madison, WI. Summer 2017.

121. Stabilization and delivery of biologics for tissue regeneration. Vail Scientific Summit, Vail, CO. Summer 2017.

122. Assembly of human tissues for discovery and therapy. Stanley Manne Children's Research Institute Seminar Series, Lurie Children’s Hospital, Chicago, IL. Fall 2017.

123. Biomanufacturing of stem cell-derived human tissues for discovery and therapy. Biomedical Engineering Society Webinar. Fall 2017.

124. Cells and microenvironment. NIDCR 2030 Workshop. National Institutes of Health. Spring, 2018.

125. Bioinspired materials for orthopedic tissue regeneration. International Section of Fracture Repair Symposium. Orthopedic Research Society Conference. Spring, 2018.

126. Driven assembly of stem cell-derived human tissues for disease modeling and discovery. Midwest LRIG Annual Conference. Spring, 2018.

127. Translating organotypic cultures to collaborations between commercial manufacturers and researchers. 3rd Annual STAR Organotypic Culture Models for Predictive Toxicology Meeting, Durham, NC. Spring, 2018.

128. Bioinspired materials for cell and gene therapies. Gordon Research Conference on Signal Transduction in Engineered Extracellular Matrices, Andover, NH. Summer 2018.

129. Nanostructured implant coatings for tissue regeneration and biologics delivery, Vail Scientific Summit, Summer 2018.

130. Bioinspired materials: versatile tools for organoid based discovery and regenerative medicine. Johnson and Johnson, Fall 2018.

131. Driven assembly of human tissues for screening applications. SLAS Conference, Washington D.C., Spring 2019.

132. Emerging biofabrication and biomanufacturing: opportunities and challenges. AIMBE Workshop on Biomanufacturing, Washington D.C., Spring 2019.

133. Driven assembly of human tissues for screening applications (Conference Plenary). Society of Toxicology conference, Baltimore, MD, Spring 2019.

134. Optimization of “Inherent Factors” in Biomanufacturing Processes. Advanced Regenerative Manufacturing Institute Summit, Manchester, NH, Fall 2019.

135. Therapeutic mRNA delivery for regenerative medicine. Vail Scientific Summit, Vail CO, Fall 2019.

136. Engineering autologous therapies for regenerative medicine. International Society for Cell and Gene Therapy Regional Conference, Madison, WI, Fall 2019.

137. Delivering new medicines to regenerate tissues and treat cancer. Research in Your Backyard Symposium, Madison, WI, Fall 2019.

138. Robust and scalable assembly of human tissues for modeling and discovery. New York Academy of Sciences, New York, NY, Fall 2019.

139. Therapeutic mRNA delivery for regenerative medicine. Surgery Research Summit, Madison, WI, Spring 2020.

140. Therapeutic delivery for regenerative medicine and COVID-19. Forward BIO Technology Roundtable, Madison, WI, Spring 2020.

141. Robust and scalable assembly of human neurovascular tissues for disease modeling and discovery, Society of Toxicology Conference, Anaheim, CA, Spring 2020. (Canceled, COVID-19)

142. Optimization of “Inherent Factors” in Biomanufacturing Processes. BMES Workshop, Washington D.C., Spring 2020. (Canceled, COVID-19)

143. Biomaterials strategies to enhance and prolong the effects of therapeutic mRNA. 8th International mRNA Health Conference, Virtual, Fall 2020.

144. Coated, patient specific bone graft cage for long bone trauma. J&J Innovation Center Conference, Virtual, Fall 2020.

Funding for Research/Education

Current/Approved External Research Funding:

|Role |Agency (Mechanism) |Dates of Project |Total Costs |Title of Project |

|1MPI |NIH (U01) |08/01/18-07/31-23|$5,000,000 |Harnessing human brain and liver microphysiological |

| | | | |systems for testing therapeutics for metastatic |

| | | | |melanoma |

|PI |NIH (R01) |4/01/19-3/31/24 |$1,250,000 |A neurovascular microphysiological system |

|PI |NIH (R01) |07/01/09- |$3,600,000 |Biomaterials for local regulation of growth factor |

| | |06/30/20 | |signaling |

|2Co-PI |NSF |2013 - 2019 |$430,000 |Substrate Independent, Spatially Resolved, Stable |

| | | | |Polymer Coatings for Studying Human Mesenchymal Stem |

| | | | |Cells |

|PI |EPA |2014-2019 |$7,000,000 |STAR Center: Human Models for Analysis of Pathways |

|PI |Shannon Family |2016-2021 |$670,000 |Musculoskeletal Regeneration Partnership |

|3Co-PI |Good Food Institute |2020-2023 |$500,000 |Crossing two kingdoms: Bioengineered clean meat in |

| | | | |plant-based tissue scaffolds |

1with John Wikswo (MPI), Vanderbilt University and Lansing Taylor (MPI), University of Pittsburgh

2with Padma Gopalan (PI), Univ. of Wisconsin

2with Masa Suzuki (PI), Univ. of Wisconsin

Completed Research Funding:

|Role |Agency (Mechanism) |Dates of Project |Total Costs |Title of Project |

|PI (trainee) |NIH (F32) |07/01/03 – |$42,928 |Self-assembly of dynamic, functional protein |

| | |06/30/04 | |matrices |

|PI |NIH (R21) |09/1/05 – |$380,214 |Matrices for spatially-controlled stem cell activity|

| | |08/30/07 | | |

|PI |NIH (R03) |03/01/06 – |$297,531 |Biomaterials for sequential growth factor delivery |

| | |02/28/09 | | |

|PI |NIH (R21) |03/01/06 – |$382,854 |Directed MSC differentiation via controlled |

| | |02/28/08 | |transfection |

|1Co-PI |UW Sports Medicine Fund |07/01/06 – |$35,000 |Sustained delivery of anabolic agents to promote |

| | |06/30/07 | |cartilage regeneration |

|PI |Wallace H. Coulter Found. |05/01/06 – |$100,000 |Biologically active coatings on bioresorbable |

| | |04/31/07 | |orthopedic implants |

|PI |Wallace H. Coulter Found. |05/01/07 – |$111,000 |Controlled protein delivery technology for treatment|

| | |04/31/08 | |of ischemic disease |

|PI |American Chemical Society |09/01/06 |$37,500 |Self-assembling, dynamic hydrogels cross-linked via |

| |(PRF Starter) |-12/31/08 | |cDNA interactions |

|PI |Draper Technology |09/01/07-08/31/08|$34,515 |Tailored biomolecules that induce orthopedic tissue |

| |Innovation Fund | | |regeneration by stem cells |

|PI |Wallace H. Coulter Found. |05/01/08-11/01/09|$95,000 |Biologically active sutures for healing of avascular|

| | | | |orthopedic tissues |

|PI |Wallace H. Coulter Found. |04/01/09-03/31/10|$100,000 |Orthopedic implants for enhanced healing |

|PI |AO Foundation |03/01/08 – |$250,000 |Enhanced bone defect healing via induced |

| | |02/28/11 | |angiogenesis and osteogenesis |

|PI |AO Foundation |01/01/10 – |$120,000 |Gene and protein delivery strategies for large bone |

| | |12/31/11 | |defect healing. |

|PI |Wallace H. Coulter Found. |04/01/10 – |$110,000 |Biologically active sutures for tendon healing. |

| | |03/31/11 | | |

|2co-I |NIH (R01) |09/01/07 – |$1,818,750 |Towards a synthetic basement membrane for the |

| | |08/31/12 |Murphy~$300K |corneal epithelium |

|3Co-PI |NSF |2009 – 2013 |$325,000 |Surface engineering strategies for studying human |

| | | |Murphy~$120K |MSCs |

|PI |NSF (MRSEC) |09/01/12-08/31/13|$60,000 |Bio-responsive materials |

|PI |NSF (CAREER award) |03/01/08 – |$475,000 |CAREER: Controlling soluble morphogen gradients in |

| | |06/01/13 | |biomaterials |

|4PI |NSF |2009 – 2014 |$450,000 |Silicate bioceramic structure and texture control on|

| | | | |activating osteoblast proliferation and |

| | | | |differentiation |

|5Co-I |NIH (R01) |2009 – 2014 |$1,800,000 |Microsphere-mediated differentiation of embryonic |

| | | | |stem cells |

|6PI |NSF |2011 – 2014 |$550,000 |Collaborative Research: Regulators of cellular |

| | | | |microenvironment and multiscale osteointegration |

|7Co-PI |AO Foundation |2012 - 2014 |$250,000 |Enhanced vascularized bone regeneration |

|PI |AO Foundation |2012 – 2014 |$250,000 |Linkage of orthobiologics to the scaffold platform |

| | | | |to promote large bone defect healing |

|8PI |NIH (R21) |2013-2015 |$275,000 |Probing biochemical/biophysical influences on endMT |

|PI |NSF (NSEC seed) |2013-2015 |$60,000 |Multivalent display of growth factor affinity |

| | | | |epitopes using poly-beta-peptides |

|9PI |NIH (R01) |2010 - 2015 |$1,800,000 |Modulation of the Immune System to Improve |

| | | | |Ligament/Ligament Graft Healing |

|PI |Discovery to Product (D2P)|2014-2015 |$150,000 |Bioassembly |

|PI |State Economic Development|2015-2016 |$160,000 |Optimized biomaterials for stem cell |

| |(SEED) | | |biomanufacturing |

|10Co-I |NIH (UH2/UH3) |2012-2018 |$10,000,000 |Human iPS/ES cell-based models for predictive neural|

| | | | |toxicity/teratogenicity |

|PI |NIH (R21) |2016-2018 |$425,000 |Matrices for optimal endogenous progenitor cell |

| | | | |recruitment and function |

|11PI |NIH (adm supp) |2016-2017 |$75,000 |Assembly of human retinal organoids. |

|12Co-I |NIH (adm supp) |2016-2017 |$100,000 |Assembly of human neural organoids for modeling of |

| | | | |Rett Syndrome. |

|PI |State Economic Development|2017-2018 |$160,000 |A novel, scaffold-free approach for therapeutic cell|

| |(SEED) | | |delivery. |

1 with Lee Kaplan (co-PI), Univ. of Wisconsin

2with Paul F. Nealey (PI), C.J. Murphy (co-I), Univ. of Wisconsin

3with Padma Gopalan (PI), Univ. of Wisconsin

4with Nita Sahai (co-PI), Univ. of Wisconsin

5with Todd McDevitt (PI), Andrew Lyon (Co-I), Georgia Institute of Technology

6with Amy Wagoner-Johnson, University of Illinois

7with Eben Alsbert, Case Western Reserve University

8with Michael Schwartz (Co-PI), University of Wisconsin

9with Ray Vanderby Jr. (Co-PI), University of Wisconsin

10with James Thomson (PI), Morgridge Institute for Research

11with David Gamm (Co-I), University of Wisconsin

12with William Daly (PI), University of Wisconsin

Completed Education/Service Funding:

|Role |Agency (Mechanism) |Dates of Project |Total Costs |Title of Project |

|1Co-PI |NIH (R13) |12/01/06 – |$13,600 |Conference support: designed macromolecular assemblies for |

| | |11/31/07 | |biomedical applications |

|2Co-PI |American Chemical Society |12/1/06 – |$5,000 |Conference support: designed macromolecular assemblies for |

| |(PRF) |11/31/07 | |biomedical applications |

|3Co-PI |Stem Cell Cluster |03/01/06 – |$60,000 |Interdisciplinary fellowships and workshops in stem cell |

| |Enhancement Grant |02/28/11 | |bioengineering, biology, and policy |

|4Co-PI |UW Stem Cell and |08/01/08-07/31/10|$200,000 |Interdisciplinary pre-doctoral and post-doctoral training |

| |Regenerative Medicine | | |program in stem cell science |

| |Center | | | |

1with Joel Collier (PI) and Theresa Reineke (co-PI), Univ. of Cincinnati

2with Joel Collier (PI) and Theresa Reineke (co-PI), Univ. of Cincinnati

3with Tim Kamp (co-PI) and Linda Hogle (co-PI), Univ. of Wisconsin

4with Clive Svendsen (co-PI), Univ. of Wisconsin

Teaching and Mentoring

Postdoctoral Fellows and Scientists Supervised:

1. Jae-Sam Lee, PhD (2006-2008)

Modular peptide growth factors for stem cell differentiation

Current position: Research Scientist, Department of Radiology, University of Virginia

2. Zhijie Sui, PhD (2006-2008)

Dynamic, protein based materials

Current position: Senior Scientist, Vertex Pharmaceuticals, Boston, MA

3. Leena Jongpaiboonkit, PhD (2006-2008)

Array-based stem cell culture, novel drug delivery systems

Current position: Lead Biomaterials Engineer, Tissue Regeneration Systems, Ann Arbor, MI

• NSF fellowship for Cell Mechano-sensitivity summer course (2007)

4. Javeed Shaikh Mohammed, PhD (2008-2009)

Dynamic, controlled, cell-interactive hydrogels

Current position: Assistant Professor, Applied Medical Sciences, King Saud University, Saudi Arabia

5. Sheeny Lan Levengood, PhD (2009-2011)

High throughput systems for 3-D stem cell culture

• Wisconsin Stem Cell and Regenerative Medicine Center Fellowship (2009-2010)

• NIH Stem Cell Training Grant (T32) Fellowship (2010-2011)

6. Michael Toepke, PhD (2009-2011)

Dynamic materials for control over cellular microenvironments

• NIH Voice Sciences Training Grant (T32) Fellowship (2009-2011)

Current Position: Scientist, Dow Corning, Midland, MI

7. Se Won Bae, PhD (2011-2012)

Bioresponsive materials

Current Position: Scientist, South Korean Government

8. James Molenda (2005-2016)

Cell and molecular biology

9. Jae-Sung Lee, PhD (2008-2014, 2017-Present)

Protein and peptide delivery from medical device coatings

Current Position: Scientist, Primorigen Biosciences, Madison, WI

10. Dan Hellenbrand (2010-Present)

Protein delivery systems for spinal cord regeneration

*Co-advised with Dr. Amgad Hanna, Surgery

11. Connie Chamberlain, PhD (2009-Present)

Biologically active “smart” devices for musculoskeletal tissue healing

12. Michael Schwartz, PhD (2010-2017)

Regulated 3-D microenvironments for stem cell culture

13. Stefan Zorn, PhD (2010-2013)

Localized growth factor sequestering on stem cell culture substrates

Current Position: Scientist, Thermo Fisher Scientific, Germany

14. Xiaohua Yu, PhD (2011-2017)

Biologically active materials for orthopedic tissue healing

15. Darilis Suarez-Gonzalez, PhD (2011-2016)

Vocal fold tissue engineering

• NIH Voice Sciences Training Grant (T32) Fellowship (2014-2016)

16. William Daly, PhD (2013-Present)

Mechanisms of biologically driven assembly

17. Bernard Binder, PhD (2014-2017)

Synthetic model systems for vascular pathology

18. Gianluca Fontana, PhD (2015-Present)

Controlled non-viral gene delivery

19. Andrew Dias, PhD (2015-2017)

Biomaterials for stem cell expansion and organoid assembly

20. Ulrika Muller (2015-Present)

Research specialist in cell and tissue culture

21. Cheryl Soref (2015-2017)

Research specialist in neural organoid assembly

22. Gaurav Kaushik, PhD (2016-Present)

Biomaterials for neural organoid assembly

23. Elizabeth Torr, PhD (2016-Present)

Research specialist in human tissue chip assembly

24. Kate Barteau, PhD (2017-Present)

Biomaterials for controlled stem cell self-assembly

25. Elizabeth Aisenbrey, PhD (2018-Present)

Biomaterials for vascular tissue regeneration

26. John Krutty, PhD (2020-Present)

Biomaterials for scale-up therapeutic cell manufacturing

doctoral Students Supervised:

1. Greg Hudalla (2004-2010, PhD, Biomedical Engineering)

Material-mediated regulation of growth factor activity

• Wisconsin Interdisciplinary Stem Cell Research Fellowship (2008-2009)

• Current position – Assistant Professor, Biomedical Engineering, University of Florida, Gainesville, FL

2. William J. King (2005-2010, PhD, Biomedical Engineering)

Harnessing protein conformational changes to control the timing of growth factor release from dynamic hydrogels

• NIH Clinical Neuroengineering Training Fellowship, 2005-2006

• NSF Graduate Research Fellowship, 2006-2009

• Current position – Scientist, Biomet Inc., Warsaw, IN

3. Stephen M. Kennedy (2007-2010, Electrical and Computer Engineering)

Controlling electric field-mediated transfection of cells in 3-D environments

*Co-advised with John Booske and Susan Hagness, Electrical and Computer Engineering

• Wisconsin Interdisciplinary Stem Cell Research Fellowship, 2008

• NIH NRSA Predoctoral Fellowship, 2008-2010

• Current position – Assistant Professor, University of Rhode Island

4. Nianli Zhang (2008-2011, Materials Science Program)

Influence of bioceramic substrates on mesenchymal stem cell phenotype

*Co-advised with Nita Sahai, Geology

• Current position – Postdoctoral Fellow, University of Michigan

5. Darilis Suarez (2005-2011)

Inorganic multilayers for controlled growth factor delivery

*Co-advised with Ray Vanderby, Jr., Orthopedics and Rehabilitation

• NASA Harriett Jenkins Pre-Doctoral Fellowship (2004-2006)

• NASA Harriet Jenkins Mini Research Award (2005, 2006)

• Current position – Lecturer, Madison College

6. Siyoung Choi (2004-2012, Materials Science)

Material-mediated delivery of plasmid DNA to stem cells

• Current position – Postdoctoral Fellow, Cornell University

7. Travelle Franklin-Ford (2005-2012, Medical Scientist Training Program)

Injectable biomaterials for controlled protein delivery

*Co-advised with Ray Vanderby, Jr., Orthopedics and Rehabilitation

• Graduate Engineering Research Scholars Fellowship (2005-2007)

• American Medical Association “Excellence in Leadership” Award (2010)

• Current Position – Medical Liaison, Zimmer

8. Justin T. Koepsel (2006-2012, Biomedical Engineering)

Controlled, spatially patterned surface chemistries for stem cell culture

• NIH Biotechnology Training Fellowship, 2006-2009

• MRS Graduate Student Award, 2011

• Current Position – Technology Lead, Mayo Ventures, Rochester, MN

9. Michelle Wilson (2008-2012, Chemical and Biological Engineering)

Controlled hydrogels for corneal epithelium regeneration

*Co-advised with Paul Nealey, Chemical and Biological Engineering

• Current position – Scientist, Kimberly-Clark Corp., Nena, WI

10. Samantha Schmitt (2009-2015, Materials Science Program)

Tailored 2-D surface chemistries for mesenchymal stem cell culture

*Co-advised with Padma Gopalan, Materials Science and Engineering

• Current position – Scientist, Illumina, San Diego, CA

11. David Belair (2010-2015, Biomedical Engineering)

Approaches for drug delivery that harness endogenous signals

• Pre-doctoral Fellowship, UW Cardiovascular Research Center

• Intern, Cellular Dynamics International, 2013.

• Current position – Scientist, Celgene, Newark, NJ

12. Eric Nguyen (2009-2016, Biomedical Engineering)

Custom hydrogel microenvironments to explore morphogen gradients

• NIH Biotechnology Training Program Fellowship, 2009-2012

• Graduate Education Research Scholars Fellowship, 2009-2014

• Intern, Genzyme Corporation, 2012.

• Pre-doctoral Fellowship, UW Cardiovascular Research Center, 2014-Present.

• Current position – Postdoctoral Fellow, National Eye Institute

13. Matt Parlato (2010-2016, Biomedical Engineering)

Affinity-based drug sequestering systems for regenerative medicine

• Current position – Scientist, Covance, Madison, WI

14. Anna Clements (2011-2018, Materials Science Program)

Delivery of inflammatory mediators for musculoskeletal wound healing

*Co-advised with Ray Vanderby, Biomedical Engineering

• Current position – Scientist, Dianomi Therapeutics, Madison, WI

15. Andrew Khalil (2012-2018, Biomedical Engineering)

Bioresponsive materials as controllable stem cell niches

• NIH Biotechnology Training Fellowship, 2012-Present

• NSF Graduate Research Fellowship, 2014-Present.

• Current position – Postdoctoral Fellow, Harvard University

16. Angie Xie (2012-2019, Biomedical Engineering)

Biomimetic strategies to promote vasculogenesis

• NIH Biotechnology Training Fellowship, 2012-2013

• NSF Graduate Research Fellowship, 2013-Present

• Current position – Scientist, Covance

17. Ngoc Nhi T. Le (2011-2019, Materials Science Program)

Injectable biomaterials for soluble growth factor sequestering

• Pre-doctoral Fellowship, Hertz Foundation

• Pre-doctoral Fellowship, GERS Program

• Pre-doctoral Fellowship, NIH Biotechnology Training Program

• Current position – Wisconsin Alumni Research Foundation

18. Hamisha Ardalani (2012-2019, Biomedical Engineering)

Biomimetic strategies to promote vasculogenesis

*Co-advised with James Thomson, Morgridge Institute for Research

19. John Krutty (2015-Present, Biomedical Engineering)

Biomimetic strategies to promote vasculogenesis

*Co-advised with Padma Gopalan, Materials Science and Engineering

20. Junsu Yun (2018-Present, Materials Science)

Polymer surface coatings for cell and tissue manufacturing

*Co-advised with Padma Gopalan, Materials Science and Engineering

21. Hannah Martin (2018-Present, DVM/PhD program)

Therapeutic protein delivery for intratumoral applications

22. Margot Amitrano (2020-Present, PhD program)

Engineered manufacturing of cell therapies

23. Josh Choe (2020-Present, MD/PhD program)

Engineered manufacturing of human organoids for cancer modeling

Masters Students Supervised:

1. Kawai Chan (2005-2006, Biomedical Engineering)

Bioinspired mineral growth on polysaccharide template materials

2. Brian J. Peret (2005-2008, Biomedical Engineering)

Controlled soluble protein gradients in 3-D hydrogel networks

• Graduate Engineering Research Scholars Fellowship, 2005-2008

3. Nick Pytel (2008-2009, Biomedical Engineering)

Affinity-based drug delivery systems for regenerative medicine

4. Nicholas Impellitteri (2009-2011, Biomedical Engineering)

3-D microenvironments for stem cell culture

Current position – Scientist, Zymergen, San Francisco, CA

5. Steve Wyche (2011, Biomedical Engineering)

Degradable microspheres for non-viral gene delivery

6. Armand Grabowski (2013, Biomedical Engineering)

Dynamic hydrogels

7. Dan Thomson (2015-2016, Biomedical Engineering)

Drug delivery for spinal cord regeneration

8. Jon Elicson (2015-2016, Biomedical Engineering)

Novel biomaterials for cell manufacturing

9. Todd Le (2015-2017, Biomedical Engineering)

Novel biomaterials for neural cell-based assays

10. Tremaan Spearman-White (2017-2018, Biomedical Engineering)

Biomimetic strategies to promote lung healing

*Co-advised with Hau Le, Surgery

11. Victoria Harms (2018-Present, Toxicology)

Biomimetic models for vascular and neural toxicology testing

• Molecular and Environmental Toxicology Program

Teaching Activities:

Undergraduate Courses Taught:

• BME 200/300 (Biomedical Engineering Design, Introductory Level) - Fall 2005, Fall 2007, Fall 2016

• BME 201 (Biomedical Engineering Design, Sophomore Level) – Spring 2008

• BME 301 (Biomedical Engineering Design, Junior Level) – Spring 2006, Fall 2014

• BME 400 (Capstone Design Course in Biomedical Engineering) - Fall 2006, Fall 2008

• BME 402 (Biomedical Engineering Design, Senior Level) – Spring 2007, Spring 2009

• BME 520 (Stem Cell Bioengineering, Senior Level) – Fall 2010, Spring 2012

Undergraduate courses – guest lectures:

• MS&E 421 (Polymeric Materials) - Fall 2005

Graduate Courses Taught:

• BME/CBE 520 (Stem Cell Bioengineering) - Fall ‘05, Fall ‘06, Spring ‘07, Spring ‘08, Spring ’09, Spring ’10.

• BME 601 (Advanced Biomaterials Laboratory) – Spring ‘09

• Anatomy 675 (Fundamentals of Stem Cell Biology) – Team Taught, Fall ‘06

• BME 601 (Advanced Stem Cell Bioengineering, Graduate Level) – Spring 2014

• BME 601 (Foundations of Innovation in the Stem Cell Industry) – Spring 2016, 2017, 2018

Graduate Courses – guest lectures:

• BME 601 (BioMEMS) - Fall 2005

• MSE 601 (Materials Science Seminar) – Fall 2005, Spring 2008, Spring 2012

• Neuroscience 700 (Neuroscience Seminar) – Spring 2006 (Mock study section evaluation)

• BME 517 (Biology in Engineering Seminar) - Fall 2006, Fall 2007, Fall 2008, Fall 2009

• EPD 670 (Business and Entrepreneurism for Engineers) – Fall 2009

• BME 545 (Extracellular Matrix: Controlling Structure and Function) – Spring 2012-2014.

Educational Initiatives:

New Course Development

• BME/CBE 520 (Stem Cell Bioengineering) - Fall ‘05, Fall ‘06, Spring ‘07, Spring ‘08, Spring ’09, Spring ’10, Fall ’10, Spring ’12, Spring ‘20.

• BME 601 (Advanced Biomaterials Laboratory) – Spring ‘09

• Cellular and Regenerative Biology 601 (Fundamentals of Stem Cells) – Fall 2012.

• BME 601 (Advanced Stem Cell Bioengineering) – Spring 2014

New Graduate Training Programs

• Interdisciplinary fellowships/workshops in stem cell bioengineering, biology, and policy (2005-Pres)

• Interdisciplinary pre-doctoral and post-doctoral training program in stem cell science (2008-Pres)

National Initiatives

• Chair of Education and Professional Development, Society for Biomaterials (2011-Pres)

• Director of Biomaterials Education Challenge competition, Society for Biomaterials (2013-Pres)

• Member of Graduate Student Awards Committee, Materials Research Society (2010-Pres)

Training Program Activities:

• Principal Investigator, Interdisciplinary Fellowship Program in Stem Cell Research (2005-Present)

• Chair, UW Interdisciplinary Stem Cell and Regenerative Medicine Training Program (2008-Pres)

• Trainer, CVRC Training Program in Translational Cardiovascular Science (2009-Present)

• Trainer and Exec Committee Member, NIH Voice Sciences Training Program (2009-Present)

• Trainer and Exec. Committee Member, NIH Vascular Surgery Training Program (2013-Present)

• Trainer, NIH Biotechnology Training Program (2005-Present)

• Trainer, NIH Neuroscience Training Program (2005-Present)

• Trainer, NIH Chemistry and Biology Interface Training Program (2005-Present)

• Trainer, UW Medical Scientist Training Program (2005-Present)

• Trainer, UW Materials Science Program (2004-Present)

Professional Activities and Service

Departmental/University Service:

Biomedical Engineering Department

• Member, Biomedical Engineering Department Graduate Committee (2005-2012)

• Member, Biomedical Engineering Department Teaching Assessment Committee (2006-09, 2014-17)

• Member, Biomedical Engineering Department Undergraduate Advising Committee (2008-2009)

• Member, Biomedical Engineering Department Policies and Procedures Committee (2008-2009)

• Faculty Senate Alternate, Biomedical Engineering Department (2009-2012)

• Chair, Faculty Promotion (Awards) Committee (2009-Present)

• Chair, Faculty Mentoring Committees (W.J. Li, R. Ashton)

• Member, Faculty Mentoring Committees (K. Saha, J. Rogers, P. Kreeger, M. McClean)

• Member, Faculty Hiring Committee (2010-2012)

Orthopedics and Rehabilitation Department

• Member, Faculty Hiring Committee (2007)

• Scientific Advisory Board, UW Orthopedic Fund (2011-Present)

• Chair, Faculty Mentoring Committee (W.J. Li)

Materials Science Program

• Member, Materials Science Program Curriculum Committee (2006-2015)

Stem Cell and Regenerative Medicine Center

• Member, Stem Cell and Regenerative Medicine Faculty Search Committee (2008)

• Member, Stem Cell and Regenerative Medicine Center Executive Committee (2008-Pres.)

• Co-Director, Stem Cell and Regenerative Medicine pre- and post-doctoral training program (2008-Pres.)

• Member, Stem Cell and Regenerative Medicine Retreat Planning Committee (2009)

• Chair, Stem Cell and Regenerative Medicine Retreat Planning Committee (2010)

• Co-Director, Stem Cell and Regenerative Medicine seed grant program (2010-Pres.)

• Co-Organizer and Co-Chair, Wisconsin Stem Cell and Regenerative Medicine Symposium (2011)

• Associate Director (2011-2012)

• Co-Director (2012-Pres.)

Wisconsin Institutes for Discovery – BioNaTES theme

• Co-chair, Faculty Search Committees (2010-2013)

• Associate Director (2011-Present)

• Discovery Fellow (2012-Present)

College of Engineering

• Member, Research Innovation Committee (2015-2016)

• Chair, Research Innovation Committee (2016-Present)

• Member, Academic Planning Council (2016-Present)

• Member, Accelerated Materials Discovery hiring committee (2014-Present)

• Member, Associate Dean for Research Selection Committee (2017)

Professional Service (Selected):

• Co-Chair, “Stem Cells” Sessions, BMES Conference, Baltimore, MD, 2005

• Co-Chair, “Tissue Engineering” Sessions, BMES Conference, Chicago, IL, 2006

• Co-Chair, “Macromolecular Assemblies” symposium, ACS Conference, Chicago, IL, 2007

• Co-Chair, “Self-Assembling Biomaterials” symposium, SFB Conference, Chicago, IL, 2007

• Co-Chair, “Biomimetic Materials” sessions, BMES Conference, Los Angeles, CA, 2007

• Co-Chair, “Engineering the Stem Cell Niche”, ACS Conference, New Orleans, LA, 2008

• Co-Chair, “Engineering Artificial Stem Cell Microenvironments”, World Biomaterials Congress, Amsterdam, the Netherlands, 2008

• Co-Chair, “Engineering Artificial Stem Cell Microenvironments”, ACS Conf., Philadelphia, PA, 2008.

• Guest Editor, Special Issue: “Self-Assembling Biomaterials”, Acta Biomaterialia, 2008

• Co-Chair, “Hydrogels: From Nanoparticulate Drug Carriers to Scaffolds for Tissue Engineering”, Controlled Release Society Conference, Copenhagen, Denmark, 2009.

• Co-Chair, “Advanced Orthopedic Materials”, BMES Conference, Pittsburgh, PA, 2009

• Chair, “MRS Graduate Student Award Presentations”, MRS Conference, Boston, MA, 2009.

• Co-Chair, “Biomaterials for Regenerative Medicine”, MRS Conference, Boston, MA, 2009.

• Co-Chair, “Designing Materials Exploiting Peptide and Protein Self-Assembly: Towards Design Rules”, MRS Conference, San Francisco, CA, 2010.

• Co-Chair, “Pluripotent Stem Cells in Regenerative Medicine”, Society for Biomaterials Conference, Seattle, WA, 2010.

• Program Committee, Society for Biomaterials Conference, Seattle, WA, 2010.

• Program Committee, Design of Medical Devices Conference, Minneapolis, MN, 2010.

• Session Co-Organizer, Biomedical Engineering Society Conference, Austin, TX, 2010.

• Co-Chair, “Controlling Microenvironment and Cell Fate”, Tissue Engineering and Regenerative Medicine International Society Conference, Orlando, FL, 2010.

• Co-Organizer, Wisconsin Stem Cell Symposium, Madison, WI, 2011.

• Co-Chair, “Pluripotent Stem Cells in Engineered Microenvironments”, Society for Biomaterials Conference, Orlando, FL, 2011.

• Co-Chair, “Self-Assembly in Cell and Tissue Engineering”, Society for Biomaterials Conference, Orlando, FL, 2011.

• Member, MRS Graduate Student Award Committee, Materials Research Society, 2010-Pres.

• Program Committee, Design of Medical Devices Conference, Minneapolis, MN, 2011.

• Co-Organizer, Frontiers of Engineering Symposium, National Academy of Engineering, San Diego, CA, 2011.

• Co-Chair, “Stem Cells and Regenerative Medicine”, IEEE-EMBS Conference, Boston, MA, 2011.

• Chair, Education and Professional Development Committee, Society for Biomaterials, 2011-Pres.

• Governing Council, Society for Biomaterials, 2011-Present.

• Co-Chair, Orthopedic Biomaterials, Biomedical Engineering Society Conference, Hartford, CT, 2011.

• Co-Chair, Bioinspired Materials, Biomedical Engineering Society Conference, Hartford, CT, 2011.

• Co-Chair, “Designing Materials Exploiting Peptide and Protein Self-Assembly: Towards Design Rules”, MRS Conference, Boston, MA, 2012.

• Co-Chair, “Polymeric Materials and Surfaces for Cell Differentiation”, American Chemical Society Conference, Philadelphia, PA, 2012.

• Co-Chair, “Biomaterials to Control Cellular Environments”, Biomedical Engineering Society Conference, Atlanta, GA, 2012.

• Member, Scientific Advisory Committee, Tissue Engineering and Regenerative Medicine International Society Conference, 2012-2013.

• Co-Chair, “Biomaterials in the Fourth Dimension – Controlling Temporal Properties”, Society for Biomaterials Conference, 2013.

• Co-Organizer. “NSF workshop on new directions in tissue engineering and regenerative medicine”, Napa, CA, 2013.

• Co-Chair. “Engineering Morphogenesis”, Tissue Engineering and Regenerative Medicine International Society Conference, 2013.

• Member, Organizing Committee, 4th International Conference on Stem Cell Engineering, San Diego, CA, 2014.

• Co-Chair, “Extracellular Programming and Reprogramming”, International Conference on Stem Cell Engineering, San Diego, CA, 2014.

• Co-Chair, “Morphogenic Peptides and Biomaterials in Tissue Regeneration”, Society for Biomaterials Conference, 2014.

• Conference Co-Chair, Regenerative Medicine Workshop, Hilton Head, SC, 2014, 2015, 2016, 2017.

• Conference Co-Chair, Emerging Technologies in Regenerative Medicine, Los Angeles, CA, 2014.

• Co-Chair, “Stem Cell and Biomaterial Interactions”, Society for Biomaterials Conference, 2015.

• Conference Co-Chair, Vail Scientific Symposium, Vail, CO, 2015, 2016, 2017

Grant Proposal Review Activities:

• Reviewer, North Carolina Biotechnology Center, Multidisciplinary Research Grants Program, 2005

• Reviewer, Austrian Science Fund, Erwin Schrodinger Program, 2005

• Reviewer, Wisconsin Industrial and Economic Development Research Program, 2006

• Reviewer, NIH Special Emphasis Panel, “Nanostructured Dental Composites”, 2006

• Reviewer, NIH Special Emphasis Panel, Bioengineering Science and Technology, 2007

• Reviewer, NSF, Chemical, Bioengineering, Environmental, and Transport Systems (CBET), 2008

• Reviewer, NSF, Biomaterials Program (BMAT), 2010

• Reviewer, NIH Biomaterials, Delivery Systems, and Nanotechnology Small Business Panel, 2010

• Reviewer, ACS-PRF program, 2011.

• Reviewer, NIH SCORE panel, 2011.

• Reviewer, AO Research Foundation Exploratory Research, 2011.

• Reviewer, AXA Research Fund Doctoral Grants, 2011.

• Reviewer, Innovation & Economic Development Research (IEDR) program, 2011.

• Reviewer, NIH Gene and Drug Delivery Systems (GDD) Study Section, 2006, 2011, 2013, 2015.

• Reviewer, NIH P41 center site review, Rutgers University, 2012.

• Reviewer, NIH SBIR Cell, Computational, and Molecular Biology IMST, 2012.

• Reviewer, NIH ICTR program, 2013.

Journal Review Activities:

• ACS Applied Materials and Interfaces

• ACS Chemical Biology

• ACS nano

• Acta Biomaterialia

• Advanced Drug Delivery Reviews

• Advanced Materials

• Advanced Functional Materials

• Advanced Healthcare Materials

• Bioconjugate Chemistry

• Biomacromolecules

• Biomaterials

• Biomaterials Science

• Biomatter

• Biotechnology Progress

• Bone

• Cells, Tissues Organs

• Chemical Communications

• Chemistry

• Chemistry and Biology

• Chemistry of Materials

• Clinical Orthopedics and Related Research

• Elsevier Books

• Embo Reports

• European Cells and Materials (eCM) Journal

• Growth Factors

• Integrative Biology

• Journal of the American Chemical Society

• Journal of Biomaterials Science – Polymer Edition

• Journal of Biomedical Materials Research A

• Journal of Biomedical Materials Research B

• Journal of Cellular Biochemistry

• Journal of Cellular Physiology

• Journal of Crystal Growth

• Journal of Materials Chemistry

• Langmuir

• Macromolecular Bioscience

• Materials Today

• Nano Letters

• Nano LIFE

• Nature Chemistry

• Nature Communications

• Nature Materials

• Nature Methods

• Nature Reviews Materials

• Polymer

• Polymer Chemistry

• Proceedings of the National Academy of Sciences

• Science Translational Medicine

• Stem Cells

• Stem Cells International

• Tissue Engineering A

• Tissue Engineering C

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