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|Present Position |Senior Consultant |
| |Department of Head and Neck Surgery |
| |Tata Medical Center |
| |Rajarhat Newtown |
| |Kolkata. India 700 156 |
| |Phone +91-3366057000 |
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|Permanent address |Sharika |
| |Chittyani Road |
| |Puthanpalli P.O. |
| |Thrissur District 680103, Kerala, India |
| |Phone-0487-2551437 |
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| |16 December 1969 |
|Date of Birth | |
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|Education and training | |
| |Premedical Education |
| |Matriculation(1986) : De Nobili School CMRI, Dhanbad, Jharkhand State, |
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| |India. |
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| |Higher Secondary(1988) De Nobili School CMRI, Dhanbad, Jharkhand State, |
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| |India. |
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| |Medical Education |
| |Bachelor in Medicine and Surgery (MBBS) in February 1994 and completed internship in May 1995 from |
| |Government Medical College, Calicut ( Kozhikode ), India |
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| |Postgraduate Medical Training |
| |Diploma in Otolaryngology from Calicut Medical College- November 1998 |
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| |Master of Surgery (M.S) Otolaryngology from Government Medical College, Calicut- June 1999 |
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| |Diploma of National Board of Examinations (Otolaryngology) - December 2001. |
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| |Magister Chirurgiae (M.Ch) In Head and Neck Oncology from Amrita Institute of Medical Sciences, |
| |India. January 2007. |
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| |Research Fellowship: National Institutes of Health, Bethesda, Maryland, USA. June 2009 |
|Professional experience | |
| |July 2010 to present- Senior Consultant in Head and Neck Surgical Oncology at Tata Medical Center, |
| |Kolkata |
| | |
| |July 2009 to July 2010: Associate Professor in Head and Neck Surgery and Plastic Reconstructive |
| |Surgery, Amrita Institute of Medical Sciences- Independent admission rights. Supervision of training |
| |program for fellows. Co-ordination of basic and translational research in the department |
| | |
| |Jan 30, 2007 to June 2009: Research Fellowship at Head and Neck Surgery Branch, NIDCD, National |
| |Institutes of Health, Bethesda, Maryland. Research involved studies on cell signaling in head and |
| |neck cancer. Trained in cell culture, isolation and analysis of Protein, DNA and RNA from cancer cell|
| |lines by Western Blot analysis, luciferase reporter activity, quantitative RT-PCR, gene silencing by |
| |si-RNA, flow cytometry for cell cycle analysis, immunohistochemistry, tissue arrays, |
| |immunoflourescence in cell lines and human tissue, cell viability and proliferation assays, Luminex ®|
| |high throughput bead-based arrays for cytokines and digital pathology (Aperio® Systems). |
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| |December 2003 to Jan 2007 :Superspecialty training |
| |Trained at Department of Head and Neck and Plastic Reconstructive Surgery, Amrita Institute of |
| |Medical Sciences, Kochi. Underwent training in major ablative surgery, skull base surgery and |
| |microvascular reconstruction for head and neck cancer in a multidisciplinary setting |
| |Training in basic molecular biology techniques like DNA and RNA extraction, PCR assays etc. |
| | |
| |Feb 2003 to December 2003: At Amrita Institute of Medical Sciences and Research Centre, Kochi as |
| |Investigator, Pfizer Research Project in addition to outpatient, surgical ,casualty and teaching |
| |assignments |
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| |July 2001 to Feb 2003: ENT Surgeon at Taluk Headquarters Hospital, Chavakkad, Thrissur District. |
| |Kerala (Government Health Services). |
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| |Dec 99 to July 2001 : |
| |ENT Surgeon at Pathanamthitta District Hospital, Kozhencherry (Government Health Services). |
| | |
| |Participated in government health programs like eradication of polio drives and control programs for |
| |Hansen’s disease and tuberculosis apart from specialty services in ENT. |
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| |Participated as Member of Disability Board in the implementation of welfare schemes for the |
| |physically disabled |
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| |Aug 99 to Dec 1999 ; Worked as Assistant ENT Surgeon to gain hands on experience in advanced |
| |techniques of ear microsurgery and functional endoscopic sinus surgery at Ashoka Hospital , Kannur , |
| |Kerala. |
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| |July 1996 to July 1999 : Selected to undergo training in Otolaryngology in a statewide entrance |
| |examination. Trained in ENT outpatient, inpatient and emergency care, surgical procedures like |
| |tonsillectomy, insertion of tympanostomy tubes, tympanoplasty, endoscopic sinus surgery, |
| |bronchoscopy, esophagoscopy, septal surgeries and ablative surgery for head and neck cancer. |
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| |June 1995 to July 1996 : Worked as primary care physician in Kozhikode district |
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| |May 1994 to May 1995 : Internship at Government Medical College, Calicut. Posted in General Surgery |
| |and allied subspecialties for 2 months and in General Medicine and allied subspecialties for 2 |
| |months. Community Health and outreach postings for 3 months. Posted by rotation in the departments of|
| |Dermatology and Venereology, Obstetrics and Gynecology, Psychiatry, Orthopedics, Otolaryngology and |
| |Disease Prevention Clinic. |
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| |Nuclear NF-κB p65 is phosphorylated at Serine 276 by protein kinase A and contributes to the |
|Bibliography |malignant phenotype of head and neck cancer. Arun P, Brown MS, Ehsanian R, Chen Z and Van Waes C. |
| |Clinical Cancer Research October 2009 15; 5974 |
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| |‘Sure closure'-skin stretching system, our clinical experience. Subramania KI, Mohit S, Sasidharan |
| |PR, Abraham MK, Arun P, Kekatpure V. Indian Journal of Plastic Surgery.2005 38(2) 132-137. |
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| |Functional reconstruction of near total glossectomy defects using composite gastro omental-dynamic |
| |gracilis flaps. Sharma M, Iyer S, Kuriakose MA, Vijayaraghavan S, Arun P, Sudhir VR, Chatni SS, |
| |Sharan R. J Plast Reconstr Aesthet Surg. 2008 Aug 27. PMID: 18760683. |
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| |Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical|
| |but not alternative nuclear factor-{kappa}B subunits in head and neck cancer. Allen C, Saigal K, |
| |Nottingham L, Arun P, Chen Z, Van Waes C. Clin Cancer Res. 2008 Jul 1;14(13):4175-85. PMID: 18593997 |
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| |NF-kappa-B in carcinoma therapy and prevention. Brown M, Cohen J, Arun P, Chen Z, Van Waes C. Expert |
| |Opin Ther Targets. 2008 Sep;12(9):1109-22. PMID: 18694378 |
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| |Attenuated Transforming Growth Factor {beta} Signaling Promotes Nuclear Factor-{kappa}B Activation in|
| |Head and Neck Cancer. Cohen J, Chen Z, Lu SL, Yang XP, Arun P, Ehsanian R, Brown MS, Lu H, Yan B, |
| |Diallo O, Wang XJ, Van Waes. C Cancer Res. 2009 Apr 15;69(8):3415-24. Epub 2009 Apr 7. |
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| |Current and Potential Inflammation Targeted Therapies in Head and Neck Cancer. Wang F, Arun P. |
| |Freidman J, Chen Z, Van Waes. C. Curr Opin Pharmacol. 2009 Aug; 9(4):389-95. Epub 2009 Jun 29. |
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| |CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 |
| |oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules. Brown MS, Diallo O, Ehsanian R, |
| |Yang XP, Arun P, Lu H, Korman V, Unger G, Ahmed K. Chen Z, Van Waes C. Clin Cancer Res. 2010 Apr |
| |15;16(8):2295-307. |
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| |YAP Dysregulation By Delta NP63-mediated Gene Repression Or Phosphorylation Promotes, Proliferation, |
| |Survival And Migration In Head And Neck Cancer. Ehsanian R, Brown M, Lu H, Yang XP, Arun P, Yan B, |
| |Duggal P, Chuang R, Sudol M, Chen Z, Van Waes C. Oncogene. 2010 Nov 18;29 (46):6160-71. |
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| |HSP90 inhibition targets the dysregulated signaling network that drives proliferation and survival in|
| |head and neck squamous cell carcinoma. Jay Friedman, Stephanie Contag, Michael Hu, Christian |
| |Freudlsperger, Vishnu Kannabiran, Pattatheyil Arun, James Mitchell, Jamey Skillings, Nicolleta |
| |Brega,Julie Kan, Zhong Chen, Carter Van Waes. Manuscript in preparation |
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| |Morbidity Profile and Functional Outcome of Modified Facial Translocation Approaches for Skull Base |
| |Tumors. Kekatpure, V, Rajan GP, Patel D, Trivedi NP, Arun P, Iyer S, Kuriakose MA. Skull Base |
| |2011;21:255-260. |
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| |Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival|
| |and migration of head and neck cancer. Liesl K. Nottingham, Carol H. Yan, Xinping Yang, Han Si, |
| |Tsu-Fan Cheng, Clint Allen, Pattatheyil Arun, David Gius, Lenny Dang, Carter Van Waes, and Zhong Chen|
| |(Manuscript submitted for publication) |
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| |Phase II Two Arm Trial of the Proteasome Inhibitor,PS-341 (VELCADETM) in Combination with Irinotecan |
| |or PS-341 Alone Followed by the Addition of Irinotecan at the Time of Progression in Patients with |
| |Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) (E1304): A Trial|
| |of the Eastern Cooperative Oncology Group. Gilbert J, Lee JW, Athanassios A, Haigentz M, Feldman LE, |
| |Jang M, Arun P, Van Waes C, Forasteire AA. ( Manuscript submitted for publication). |
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| |Book Chapter-Cancer of the Skin and Ear. Essentials of Head and Neck Cancer . Alberto Staffieri, Paul|
| |Sebastian, Madan Kapre, Bipin T Varghese, Rehan Kazi (Eds). Byword Books. ISBN-13:978-8181930712 |
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| |Thesis for M.S (ENT): Analysis of intracranial complications of middle ear infection |
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| |A multicenter double- blind double dummy comparative trial of Azithromycin SR versus Levofloxacin in |
| |the treatment of acute sinusitis in adults. Conducted by Department of Otolaryngology, Amrita |
| |Institute of Medical Sciences during 2003-2004 |
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|Completed Research Projects | |
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| |Phase II, randomized placebo-controlled trial of chemoprevention of oral premalignant lesions using |
| |Curcumin. |
| |Sponsored by Department of Biotechnology, Govt of India |
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| |Effect of Topically applied turmeric/curcumin on the hair growth when used in conjunction with |
| |Variable Pulse Light exposure in mice |
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|Ongoing Research Projects |Effect of Inhibition of Nuclear Factor kappa B (NF-κB) Using Topically Applied Curcumin on Healing of|
| |Chronic Wounds |
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| |Aetiopathological Considerations and Management of Fungal Sinusitis: South Zone Annual Conference of |
| |Association of Otolaryngologists of India.( AOI ), Mar.1997 |
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| |Mucoepidermoid Carcinoma of the Ethmoids: A discussion on diagnostic and therapeutic challenges posed|
|Papers Presented |by an extensive slow growing tumour in the elderly. |
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| |The Role of ESS in the Management of Ethmoid polypi: A comparative study between conventional and |
| |endoscopic sinus surgery: South Zone Conference of AOI, Bangalore, June 1998 |
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| |Upper Airway Obstruction: A ready reckoner for the field physician and junior doctor when faced with |
| |this common but life threatening emergency. ‘Resuscitation’.Conference of Anaesthesiologists of |
| |South India, Calicut 1999 |
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| |Minimally invasive management of the neck in cancer of the oral cavity: Role of lymphoscintigraphy: |
| |Kerala State Annual meet of Association of Otolaryngologists of India. Nov 2004 and at the 4 th |
| |National conference of the Foundation for Head and Neck Oncology, India. |
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| |Tumors of the Skullbase. Tuesday Specialty presentation at Amrita Institute of Medical Sciences. |
| |September 2005 |
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| |Facial Translocation Approach : A Reliable portal to the Skullbase. Annual Conference of Association |
| |of Otolaryngologists of India, Kerala Branch. October 2005. |
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| |Applications of Facial translocation approach in Head and Neck Oncology. Annual national meeting of |
| |Foundation for Head and Neck Oncology. Lucknow. India. January 2006 |
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| |Distraction Osteogenesis of the Craniofacial Skeleton. Annual National Conference of |
| |Otolaryngologists of India. Lucknow. January 2006 |
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| |Evaluation and Management of Unknown primary presenting with cervical lymph node metastasis. AHEAD |
| |2006 ( Amrita Head and Neck Postgraduate Teaching Program, Feb 2006.) |
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| |Overview of malignancies of the ear and temporal bone. AHEAD 2006 ( Amrita Head and Neck Postgraduate|
| |Teaching Program, Feb 2006.) |
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| |Evolving Trends in the Management of Tongue Cancers. Tuesday Specialty Presentation. AIMS, Kochi. May|
| |23 2006. |
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| |Functional Reconstruction of the Tongue using Composite Stomach and Gracilis free flap. Case |
| |Presentation. National Meeting of Foundation of Head and Neck Surgery, Udaipur, India. October 2006. |
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| |Nuclear localized NF-κB Rel A is phosphorylated at Serine 276 by protein kinase A and contributes to |
| |the malignant phenotype of head and neck cancer- Poster presentation at NIH Research Festival, Oct |
| |14-17, 2008, Bethesda, MD, USA. |
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| |NF-κB Rel A phosphorylation at Serine 276 by protein kinase in head and neck cancer- Poster |
| |presentation at Annual Meeting of AACR, April 17-22, Denver, Colorado, USA |
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| |Head and Neck Cancer: an Overview: Invited lecture at the District meeting of Indian Medical |
| |Association, Malappuram. May 2005 |
| |Current Concepts In The Management Of Carcinoma Of The Tongue: Invited lecture at the monthly meet of|
| |Association of Otolaryngologists of India, Kochi Chapter. India |
| |Early Detection of Oral Cancer and Chemoprevention- Annual Meet of Kochi Chapter of Indian Dental |
| |Association, Kochi. Sep 2009 |
|Invited Lectures |Unknown Primary in the Head and Neck- Panelist. Panel Discussion. Kentcon 2009. Kerala Chapterof |
| |Association of Otolaryngologists of India. Sep 2009. Trichur |
| |Voice Rehabilitation after Laryngectomy-AHEAD 2010. Amrita Postgraduate Teaching Program Feb 2010 |
| |Premalignant and Malignant Lesions of the Oral Cavity. Peripheral meet of the Foundation for Head and|
| |Neck Surgery, Jalandhar, Punjab |
| |Prognostic Factors in Head and Neck Cancer. Panelist. Panel Discussion. Foundation of Head and Neck |
| |Oncology Annual Meeting , Oct 5-9, Goa. India |
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| |South Zone Annual Conference of Association of Otolaryngologists of India.( AOI ),Chennai. Mar.1997 |
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| |Association of Otolaryngologists of India, Karnataka Chapter Conference, Belgaum. October 1997 |
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| |South Zone Conference of AOI, Bangalore, June 1998 |
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| |Otology live surgery CME, Kochi. May 2003 |
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|Workshops/ Conferences attended |Clinical research methodology workshop, AIMS, Kochi. May 2004 |
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| |International Endoscopic Sinus Surgery Workshop , AIMS Kochi October 2004. |
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| |Annual National conference of Head and Neck Oncology Foundation, Hyderabad, January 2005. |
| |Annual National Conference of the Association of Otolaryngologists of India, Hyderabad, January 2005.|
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| |First Amrita Head and Neck Cancer Teaching Program. 20 to 22 May 2005 |
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| |International CME and Surgical workshop on Head and Neck and Skullbase Tumors, Mangalore, India . |
| |23-25 September 2005. |
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| |Annual Conference of Otolaryngologists of India, Kerala State Branch. Manjeri. October 2005. October |
| |1-2 ,2005 |
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| |7 th Annual Conference of Skullbase Society of India. Kochi, India. 21 to 23 October 2005 |
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| |Annual national meeting of Foundation for Head and Neck Oncology. Lucknow. India. January 2006 |
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| |Annual National Conference of Otolaryngologists of India. Lucknow. January 2006 |
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| |AHEAD 2006: Amrita Head and Neck Oncology Postgraduate teaching program. Feb 2006. Kochi, India. |
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| |Annual Meeting of Association of Otolaryngologists of India , Malabar Branch at Calicut .May 21, |
| |2006. |
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| |Annual Meeting of Association of Otolaryngologists of India, Travancore Branch at Alappuzha. May 28, |
| |2006. |
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| |Cancer and Inflammation. National Institutes of Health, Bethesda, USA. 9-10 October 2007. |
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| |NCCN Update on Treatment Guidelines in Head and Neck Cancer. Baltimore , USA. |
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| |7th International Conference on Head and Neck Cancer, July 19-23, 2008. San Francisco, USA. |
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| |Annual Meeting of American Association of Cancer Research, April 17-22, 2009. Denver, Colorado, USA |
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| |Annual Meeting of Foundation for Head and Neck Oncology , Kochi ,India. Oct 2009 |
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| |Foundation of Head and Neck Oncology Annual Meeting , Oct 5-9, Goa. India |
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| |Temporal bone dissection course , Perintalmanna, Kerala. Feb 1999 |
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| |Good Clinical Practice Workshop Mumbai ( Bombay), India. Feb 2003 |
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| |Hands on training programme in Orthognathic Surgery, AIMS Kochi September 2004 |
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| |Medical Informatics Workshop. AIMS, Kochi. Mar 2005 |
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|Supplemental Training |Amrita Head and Neck Reconstruction Course. Five day hands on workshop on microvascular anastomosis |
| |on animals and hands on cadaver free flap harvest. Kochi India |
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| |Australia and Asia Pacific Clinical Oncology Development Workshop ( ACORD) , Brisbane, Australia. Sep|
| |3-9, 2006 |
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| |Workshop on Stem Cells as Targets for Cancer Prevention and Early Detection. National Cancer |
| |Institute, Bethedsa, USA. May 14-15, 2007. |
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| |Bridging the Gap Between Preclinical and Clinical Evaluation of Therapeutic Candidates. National |
| |Institute of General Medical Sciences, NIH, USA. July 30- Aug 1, 2007. |
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| |Dr. C.A. Kurian Gold Medal for best paper at the Annual Conference of AOI, Malabar Branch in May 1997|
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| |Dr. Gopalakrishna Pillai Memorial Gold Medal for best paper at the annual conference of |
| |Otolaryngologists of Kerala state. Nov 2004 |
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| |FHNO Gold Medal for the best free paper at the 4 th National Conference of the Foundation for Head |
| |and Neck Oncology, Hyderabad, India. Jan 2005 |
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| |Dr. P.A. Shah Junior Consultant Award for best paper at the National meet of ENT Surgeons ,India. |
|Awards and achievements |January 2006 |
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| |Dr. C. Prabhakaran Gold Medal for best video presentation. Annual meeting of Otolaryngologists of |
| |Kerala State. Sept 2006. |
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| |Best Research Proposal Award: National Meeting of Foundation for Head and Neck Oncology In India. Oct|
| |2009, Kochi. |
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| |Oral Cancer screening camps at outreach areas of Kollam , Idukki and Alleppey districts 2005-2006 |
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| |Presented talk shows on Amrita Television Channel, India on the following themes |
| |Cancer of the larynx- April 2006 |
| |Early detection of oral cancer-May 2006 |
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|Community Initiatives | |
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-----------------------
Phone-+91- 8017133255
Email: arunpattu@
pattatheyil.arun@
Pattatheyil Arun
Associate Consultant
Head and Neck Surgery
Tata Medical Center Cancer Hospital Rajarhat Newtown
Kolkata. India 700 156 India
Dated: 16 Dec 2011
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