CURRICULUM VITAE



SUDHA SESHADRI, MBBS, MD, DM

|Current Designation: Associate Professor, Department of Neurology, |

|Co-Director of Medical Education for Residency Program, |

|Boston University School of Medicine |

|Investigator, The Framingham Heart Study |

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|Address: 715 Albany Street, Room B 602, Boston, MA 02118 |

|Phone: 617-414-1337; Fax: 617-638-8086; Email: suseshad@bu.edu |

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|ACADEMIC TRAINING: | | | |

|Doctor of Medicine |All India Institute of Medical Sciences, |1992 | |

|(D.M.)-Neurology |New Delhi, India | | |

| | | | |

|Doctor of Medicine |All India Institute of Medical Sciences, |1988 | |

|(M.D.)- Medicine |New Delhi, India | | |

| | | | |

|Bachelor of Medicine, Bachelor of Surgery|Christian Medical College, Vellore & |1986 | |

|(M.B.B.S.) |Madras Medical College, Madras, | | |

| |Madras University, India. | | |

POST_DOCTORAL TRAINING:

Residency: Internship in Internal Medicine (2001-2002) and Residency in Neurology (2002-2005), Boston Medical Center, Boston, MA. (Chief Resident, July 2004 to June 2005)

1986-1988: Junior Resident, Internal Medicine, All India Institute of Medical Sciences, New Delhi, India (Residency training in Internal Medicine)

1989: Senior Resident (Registrar), Dept. of Internal Medicine & Research Officer, Dept. of Neurology, AIIMS, New Delhi

1990-1992: Senior Resident, Neurology, AIIMS, New Delhi, India. (Residency training in Neurology)

July 1993 to April 1996: Fellow in Neurology, University of Massachusetts Medical Center, Worcester, MA, U.S.A.

October 1998 to April 2001: Post-doctoral Fellow, Department of Neurology, Boston University School of Medicine, Boston, MA and Investigator, Framingham Heart Study, Framingham, Massachusetts, U.S.A.

Medical Licensure: Massachusetts (#209711); Medical Council of India (#29797)

Board Certification: Diplomate of the American Board of Psychiatry and Neurology (2006) #53876

Academic Appointments

April 1996 to April 1998: Assistant Professor of Neurology (tenured, full time), AIIMS, New Delhi, India

April 1998 to September 1998: Assistant Professor of Neurology (tenured, full time), Sree Chitra Thirunal Institute of Medical Science and Technology, Trivandrum, Kerala, India.

May 2001 to May 2007: Assistant Professor, Department of Neurology, Boston University

May 2007 onwards: Associate Professor, Department of Neurology, Boston University, Boston

Additional responsibilities include Co-Director of Medical Education for Residency Program and Investigator, Framingham Heart Study.

Hospital Appointments:

Attending Faculty (Assistant Professor) in Neurology, All India Institute of Medical Sciences, New Delhi, India

April 1998 to Sept 1998: Faculty (Assistant Professor) in Neurology, Sree Chitra Thirunal Institute of Medical Science and Technology, Trivandrum, Kerala, India.

July 2005 onwards: Attending Neurologist; full clinical privileges since July 2005.

May 2007 onwards: Associate Professor, Department of Neurology, Boston University

Honors/Awards

National High School Science Talent Scholar; Community Orientation Program Prize for best undergraduate rural health project; Thomas Dina Prize for Physiology; Dhananjay Abhyankar Memorial Award for best undergraduate research essays in Physiology; George Chacko Memorial Award for Excellence in Preclinical Sciences; Dr. A. Venugopal Medal in Urology, E. Merck Gold Medal in Neurology and Allied Sciences (Neurological Society of India), Boston University Department of Neurology Resident Award for Excellence in Teaching (2006); Department of Neurology Resident Award for Outstanding Dedication to Resident Education (2007), Marquis Who’s Who 2008.

Professional Societies: Member: American Academy of Neurology (also member of Neuroepidemiology, Stroke, Neurogenetics and Geriatric subsections); American Stroke Association; Scientific Council of American Stroke Association, American Medical Association; Massachusetts Medical Society; World Federation of Neurology; Alzheimer’s and Related Disorders Society of India; Neurological Society of India, Indian Academy of Neurology, Indian Epilepsy Society, Alpha Omega Alpha.

Committee Responsibilities: Graudate Medical Education (Neurology); Leader Neurogenetics and Dementia End-Points Review Committees; Member 100K Publications and Steering Committees, SHARe Replication and Scientific Committees for the Framingham Heart Study, Dean's Junior Faculty Committee for the Development of Strategic Missions, Goals and Objectives at Boston University School of Medicine. NIA Alzheimer’s Disease Genetics Planning Work Group; AAN Scientific Abstract Review Committee 2008

Reviewer for Neurology, Circulation, Diabetes Care, Journal of Neurological Sciences, Journal of Neurology, Journal of Geriatric Neurology and Psychiatry, Clinical Chemistry and Laboratory Medicine, BMC Neurology; Neuroscience and Biobehavioral Reviews, Stroke, Lancet Neurology.

Associate Editor: Journal of Alzheimer Disease.

INVITED LECTURES:

|Date |Occasion/Venue |Topic |

|2007 |American Diabetes Association |Link Between Alzheimer’s Disease and Diabetes- Is there a Correlation? |

|2007 |American Academy of Neurology: Contemporary |Genetic Correlates of Brain Aging on MRI and Cognitive Test Measures: Genome |

| |Clinical Issues Plenary Session |Wide Association Analyses in the Framingham Heart Study. |

|2006 |Presentation to Alzheimer's Advisory Board at |Diabetes, Obesity and Insulin Resistance. How do they alter the risk and |

| |Boston University School of Medicine |severity of Alzheimer's Disease? |

|2006 |Boston Stroke Society Meeting, Keynote Speaker |Vascular Dementia and Vascular Cognitive Impairment: Insights from the |

| | |Framingham Study |

|2005 |Boston University Alzheimer’s Disease Center Grand |Homocysteine in Brain Aging and Dementia: Insights from the Framingham Study |

| |Round | |

|2004 |Dept. Of Neurology, Grand Round, Boston Medical |Dementia: Potential Pathways to Primary and Secondary Prevention. |

| |Center | |

|2003 |Dept. Of Neurology, Grand Round, Boston Medical |Homocysteine and the Brain: Insights from the Framingham Study |

| |Center | |

| |Dept. of Clinical Pathology Grand Round, Brigham |Homocysteine and the Brain: Risk of Developing Alzheimer’s Disease and |

| |and Women’s Hospital |Dementia |

| |General Federation of Women’s Clubs of |Contributions of the Framingham Study to Women’s Health, Heart Disease and |

|1999 |Massachusetts |Dementia |

| |14th International Conference of Alzheimer’s |Caregiving for People with Dementia: ‘Eastern needs are different and unique |

|1998 |Disease International |solutions are needed.’ |

| |Third International Symposium and Workshop on Sleep|Sleep in Dementia, Parkinson’s disease, Stroke and other selected neurological|

| |Disorders-ISWSD 98 |disorders |

| | |Clinical profile of dementia |

| |National Symposium on Dementia and Cognitive | |

| |Neurology | |

| | |Non-Alzheimer degenerative dementias- a clinical approach |

| | |An approach to the differential diagnosis and management of dementia in |

| | |adults |

| |All India Radio, Delhi |Management of Epilepsy (live interactive session) |

|1997 | | |

| | | |

| |National Workshop on Management of Common |Approach to a patient with meningitis |

| |Neurological Disorders | |

| |Symposium on Brain Aging |Current Management of Dementia |

| |Continuing Medical Education Program for General |Management of Migraine and other Headaches |

| |Practitioners | |

|1994 |Public lecture at the Sundaram Medical Foundation, |Importance of Clinical Epidemiology |

| |Madras. | |

BIBLIOGRAPHY

Original peer reviewed publications

1. Vasan RS, Seshadri S, Narula J. Atrial Natriuretic Peptide- an atavistic hormone? Int J Cardiol 1989; 22: 407-408.

2. Vasan RS, Seshadri S, Narula J. ANP - Effect yes, role no. Int J Cardiol 1989; 25: 142.

3. Seshadri S, Jain S, Maheshwari MC. Rehabilitation in multiple sclerosis. Indian J Disability and Rehabilitation 1990; July-December: 31-43.

4. Vasan RS, Seshadri S. Is the routine chest X-ray necessary? Natl Med J of India 1991;4: 205.

5. Seshadri S, Narula J, Chopra P. Asymptomatic eosinophilic myocarditis: 2+2=4 or 5? Int J Cardiol 1991;31: 348-349

6. Seshadri S, Vasan RS, Vijayakumar M, Reddy KS, Ahuja GK, Shrivastava S. Comprehensive evaluation of cardiac function in myasthenia gravis. Neurology India 1991; 39: 169-174.

7. Behari M, Singh KK, Seshadri S, Prasad K, Ahuja GK. Botulinum toxin in blepharospasm and hemifacial spasm. J Assoc Phy Ind 1994; 42(3): 205-208.

8. Seshadri S, Jain S, Maheshwari MC. Neurological manifestations of AIDS. J Assoc Phy Ind 1994; 42(4): 309-310,315.

9. Seshadri S, Drachman DA, Lippa CF. Apolipoprotein E and the lifetime risk of Alzheimer's disease: What physicians know and what they should know. Arch Neurol 1995;52:1074-1079.

10. Seshadri S, Wolf PA, Beiser A, Au R, McNulty K, D’Agostino RB. Lifetime risk of dementia and Alzheimer’s disease: The impact of mortality on risk estimates in the Framingham Study. Neurology 1997;49:1498-1504.

11. Tandon R, Khanna S, Sharma MC, Seshadri S, Menon V. Subacute sclerosing panencephalitis presenting as optic neuritis. Indian J Ophthalmol. 1999 Dec;47: 250-2.

12. Beiser A, D’Agostino RB, Seshadri S, Sullivan LM, Wolf PA. Computing estimates of incidence, including lifetime risk: Alzheimer’s disease in the Framingham Study. The Practical Incidence Estimators (PIE) macro. Statistics in Medicine 2000;19: 1495-1522.

13. Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia. Lancet 2000;356:1627-31.

14. Seshadri S, Zornberg GL, Derby LE, Myers MW, Jick H, Drachman DA. Postmenopausal estrogen replacement therapy and the risk of Alzheimer’s disease. Arch Neurol 2001;58:435-440.

15. Tripathi M, Seshadri S, Padma MV, Jain S, Maheshwari MC, Behari M. Serum cobalamin levels in dementias. Neurology India 2001:49:284-6.

16. Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Dementia and statins- reply [letter]. Lancet 2001;357: 880-881.

17. Seshadri S, Wolf PA, Beiser A, Vasan RS, Wilson PW, Kase CS, Kelly-Hayes M, Kannel WB, D'Agostino RB. Elevated midlife blood pressure increases stroke risk in elderly persons: The Framingham Study. Arch Intern Med. 2001;161: 2343-50.

18. Zhang Y, Seshadri S, Ellison RC, Heeren T, Felson DT. Bone mineral density and verbal memory impairment: Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2001;154:795-802.

19. Vasan RS, Massaro JM, Wilson PW, Seshadri S, Wolf PA, Levy D, D'Agostino RB. Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study. Circulation. 2002;105:48-53.

20. Vasan RS, Beiser A, Seshadri S, Larson MG, Kannel WB, D'Agostino RB, Levy D. Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA 2002; 287:1003-10.

21. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346: 476-83.

22. Seshadri S, Wolf PA. Homocysteine and dementia – Reply. N Engl J Med 2002; 346: 2008.

23. Tan ZS, Seshadri S, Beiser A, Wilson PW, Keil DP, Tocco M, D’Agostino RB, Wolf PA. Plasma cholesterol level as a risk factor for Alzheimer’s disease: the Framingham Study. Arch Intern Med 2003; 163:1053-7.

24. Elias MF, Sullivan LM, D’Agostino RB, Elias PK, Beiser A, Au R, Seshadri S, DeCarli C, Wolf PA. Framingham Stroke Risk Profile and Lowered Cognitive Performance. Stroke 2004;35: 404-409.

25. Ivan CS, Seshadri S, Beiser A, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Dementia after stroke: The Framingham Study. Stroke 2004;35: 1264-69.

26. Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D'Agostino RB, DeCarli C. Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study. Stroke 2004;35: 1857-61.

27. Seshadri S, Wolf PA, Besier A, Elias MF, Au R, Kase CS, D’Agostino RB, DeCarli C. Stroke Risk Profile, Brain Volume and Cognitive Function: The Framingham Offspring Study. Neurology 2004;63: 1591-99.

28. Seshadri S, Beiser A, Ivan CS, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Does preventing stroke prevent all kinds of dementia? Response. Stroke 2004;35: 2437.

29. Au R, Seshadri S, Wolf PA, Sullivan L, D’Agostino RB. New Norms for a new generation: cognitive performance in the Framingham Offspring Cohort.Experimental Aging Research 2004;30: 333-358.

30. Zaldy ST, Seshadri S, Beiser A, et al. Bone mineral disease and the risk of Alzheimer’s disease. Arch Neurol 2005;62: 107-111.

31. Ellias MF, Sullivan LM, D’Agostino RB, Elias PK, Jacques PF, Selhub J, Seshadri S, Au R, Beiser A, Wolf PA. Homocysteine and cognitive performance in the Framingham Offspring Study: age is important. Am J Epidemiol 2005;162:644-53.

32. Seshadri S, Beiser A, et al. Lifetime risk of stroke and dementia. Stroke 2006; 37(2):345-50.

33. Au R, Massaro JM, Wolf PA, Young ME. Beiser AS, Seshadri S, D'Agostino RB, DeCarli C. Association of white matter hyperintensity volume with cognitive functioning- The Framingham Heart Study. Arch Neurol 2006;63:246-250.

34. Elias MF, Sullivan LM, Elias PK, Vasan RS, D’Agostino RB, Seshadri S, Au R, Wolf PA, Benjamin EJ. Atrial fibrillation is associated with lower cognitive performance in the Framingham Offspring men. Journal of Stroke and Cerebrovascular Diseases 2006;15:214-222.

35. McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri S, Kubilus CA, Drake J, Drake BS, Wolf PA. Pathological involvement of the visual association cortex in cognitively intact, mildly impaired and demented subjects with Alzheimer’s Disease. Neuropathol Exp Neurol. 2006;65:621-30.

36. Akomolafe A, Beiser AS, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S. Diabetes mellitus and risk of developing Alzheimer’s dementia: results from the Framingham Study. Arch Neurol 2006; 63:1551-5.

37. Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA. Temporal trends in incidence, lifetime risk, severity and mortality of stroke over the past fifty years. JAMA 2006;296:2939-46.

38. MF Elias, LM Sullivan, EJ. Benjamin, PK Elias, RB D’Agostino, Sr., PA Wolf, Seshadri S, Au R, Vasan RS. Left Ventricular Mass, Blood Pressure and Lowered Cognitive Performance in the Framingham Offspring. Hypertension. 2007;49:439-45.

39. Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan R, Larson MG, Meigs JB, Keaney JF, Lipinska I, Kathiresan S, Benjamin EJ, DeCarli C.Inflammatory Biomarkers are Associated with Total Brain Volume: The Framingham Heart Study. Neurology 2007;68:1032-1038.

40. Wolf PA, Beiser A, Elias MF, Au R, Vasan RS, Seshadri S. Relation of Obesity to Cognitive Function: Importance of Central Obesity and Synergistic Influence of Concomitant Hypertension. The Framingham Heart study. Current Alzheimer Research 2007;4:111-116.

41. Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf PA, Seshadri S. Inflammatory markers and the risk of Alzheimer’s disease: The Framingham Study. Neurology 2007;68:1902-1908.

42. Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D’Agostino RB, DeCarli C, Atwood LD, Wolf PA. Genetic correlates of brain aging on MRI and cognitive test measures: a genome wide association and linkage analysis in the Framingham study. BMC Med Genet 2007, 8 (Suppl 1): S15 .

43. Larson MG, Atwood LD, Benjamin EJ, Cupples LA, D’Agostino RB, Sr., Fox CS, Diddahally RG, Guo CY, Heard-Costa NL, Hwang SJ, Lunetta KL, Murabito JM, Newton-Cheh C, O’Connor GT, O’Donnell CJ, Seshadri S, Vasan RS, Wang TJ, Wolf PA, Levy D. Framingham Heart Study 100K Project: Genomewide Associations for Cardiovascular Disease Outcomes. BMC Med Genet 2007, 8 (Suppl 1): S5.

44. Lunetta KL, D’Agostino, RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM. Genetic Correlates of Longevity and Selected Age-related Phenotypes: Genome-wide Association Study in the Framingham Study. BMC Med Genet 2007, 8 (Suppl 1): S13. .

45. Cupples LA, Arruda H, Benjamin EJ, D'Agostino Sr RB, Demissie S, Destefano AL, Dupuis J, Falls K, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa N, Hwang SJ, Kathiresan S, Kiel DP, Larson MG, Laramie JM, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey MA, Qiong Y, Seshadri S, Vasan RS, Wilk JB, Wolf PA, Atwood LD: The Framingham Heart Study 100K SNP genome-wide association study resource: Overview of 17 phenotype working group reports. BMC Med Genet 2007, 8 (Suppl 1): S1. .

46. Seshadri S, Wolf PA, Besier A, Au R, Selhub J, Jacques PF, Rosenberg IH, D’Agostino RB, DeCarli C. Association of elevated plasma homocysteine levels with subclinical brain injury: relation to silent brain infarcts, white matter hyperintensity and MRI brain volume in the Framingham Offspring. Arch Neurol 2007 [in press].

Invited Reviews

47. Seshadri S, Wolf PA. Homocysteine and the brain: vascular risk factor or neurotoxin? [Reflection and Reaction]. Lancet Neurology 2003;2:405.

48. Seshadri S. Selected Summary: Nucleic acid amplification tests for tuberculous meningitis. A systematic review of diagnostic accuracy. Natl Med J India 2003;16: 260-261.

49. Seshadri S. Methodology for measuring cerebrovascular disease burden. Int Rev Psych 2006;37:345-50

50. Seshadri S. Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer’s disease? J Alz Dis 2006;9:393-8.

51. Seshadri S, Wolf PA. Lifetime Risk of Stroke. Lancet Neurology 2007 [in press, expected Dec].

TEXTBOOKS

Vasan RS, Seshadri S. Textbook of Internal Medicine. Orient Longman, Madras, India. 1998. [Selected by the National Book Trust of India for subsidization].

Vasan RS, Seshadri S. Medicine at a glance- A companion to the ‘Textbook of Internal Medicine.’ Orient Longman, Madras, India. 1998.

CHAPTERS

Seshadri S, Drachman DA. Aging and dementia: Principles, evaluation and diagnosis. Pages 237-251. In Asbury AK, McKhann G, McDonald WI, Goadsby PJ, McArthur JC, eds., Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles. 3rd Ed. Cambridge University Press, Cambridge, U.K.

Dissertations:

(Thesis submitted to the faculty of the All India Institute of Medical Sciences, in partial fulfillment of the requirement for the degree of Doctor in Medicine (Internal Medicine), awarded in 1988 and the degree of Doctor in Medicine (Neurology), awarded in 1992)

1. Seshadri S, Jain S, Pande JN, Maheshwari MC. Brain-stem auditory and visual evoked potentials in patients with moderate to severe iron deficiency anemia.

2. Seshadri S, Jain S, Maheshwari MC. Randomized double-blind, placebo controlled trial of nimodipine in acute ischemic stroke.

3. Seshadri S, Vasan RS, Ahuja GK, Shrivastava S, Reddy KS. Diastolic dysfunction in myasthenia gravis.

Dissertations mentored:

(Thesis submitted to the faculty of the All India Institute of Medical Sciences, in partial fulfillment of the requirement for the degree of Doctor in Medicine (Neurology), awarded 1996-98)

1. Choudhary SK, Seshadri S, Behari M, Prasad K. Hindi version of the Folstein MMSE- Agreement and construct validity in educated bilingual hospitalised subjects.

2. Singh S, Seshadri S, Behari M. Effect of levodopa on cognition in patient’s with early Parkinson’s disease-evaluation of memory and frontal lobe functions.

3. Gorthi SP, Seshadri S, , Jain S, Padma MV, Maheshwari MC. Tiagabine and cognitive function in refractory epilepsy.

4. Nath J, Gupta S, Seshadri S, Behari M, Khandewal SK. A neuropsychological study of patients with Alzheimer’s disease.

Abstarcts presented at national and international meetings in last 4 years:

1. Seshadri S, Wolf PA, Besier A, Au R, Wilson PWF, Selhub J, Jacques PF, Rosenberg IH, D’Agostino RB, DeCarli C. Elevated plasma homocysteine levels are associated with subclinical brain injury in healthy adults: relation to silent cerebral infarcts, white matter hyperintensity and MRI brain volume in the Framingham Offspring. Neurology 2003; 60 (Suppl 1): A80.

2. Auerbach SH, Au R, Beiser A, Seshadri S, Wolf PA. Mild Cognitive Impairment: 25 year follow-up in the Framingham Study. Neurology 2003; 60 (Suppl 1): A244.

3. Najarian R, Seshadri S, Beiser A, Au R, Wolf PA. Blood pressure, weight loss and Alzheimer’s disease: Insights from the Framingham Study. Neurology 2003;60 (Suppl 1): A207.

4. Seshadri S, Beiser A, Vasan RS, DeCarli C, Wang TJ, Au R, Larson MG, Levy D, Wolf PA. Association of plasma atrial and B-type natriuretic peptides with silent cerebral infarcts and white matter hyperintensity on brain magnetic resonance imaging. Presented at the 29th International Stroke Conference, San Diego CA, Feb 2004.

5. Seshadri S, Beiser A, Kelly-Hayes M, Wolf PA. Parental occurrence of stroke and risk of stroke in their children: The Framingham Study. Stroke 2006; 37:634.

6. Das RR, Seshadri S, Beiser AS, Himali JJ, Au R, Kelly-Hayes M, Kase CS, Benjamin EJ, Polak JF, O’Donnell CJ, D’Agostino RB, DeCarli C, Wolf PA. Prevalence and correlates of silent cerebral infarcts in the Framingham Offspring. Stroke 2006; 37: 672.

7. DeStefano AL, Wolf PA, Seshadri S, Nguyen A, Massaro JM, Beiser A, Au R, DeCarli CD. Substantial Heritability of Total Brain and Temporal Lobe Volume in the Framingham Offspring Study. [poster presentation at American Academy of Neurology meeting, 2006].

8. Romero JR, Seshadri S, Beiser AS, Au R, DeCarli C, Vasan RS, Wolf PA. Matrix metalloproteinases are associated with MRI indices of brain ischemia and aging: The Framingham Study. [platform presentation at American Academy of Neurology meeting, 2006].

9. Vitale S, Cabral H, DeCarli C, Seshadri S, Wolf PA, Au R. Decline in Mini-mental state examination in subjects without dementia is associated with changes on volumetric brain MRI in the Framingham Offspring [presented at the 34th annual meeting of the International Neuropsychological Society, Boston, MA, February 2006].

10. Bristow KQ, Au R, Massaro JM, Seshadri S, Wolf PA, Kelly-Hayes M, DeCarli C. Relationship of silent cerebral infarctions and white matter hyperintensities to cognitive performance: the Framingham offspring study. [poster presentation at the Epidemiology of Alzheimer’s Disease conference, San Diego, CA, April 2006].

11. Seshadri S, Massaro JM, Manning WJ, Au R, Beiser AS, Gona P, Petrea RE, Jefferson AL, Benjamin ES, Vasan RS, D’Agostino RB, O’Donnell C, DeCarli C, Wolf PA. Association of Aortic Plaque Measures with Indices of Brain Aging on Volumetric Brain MRI in the Framingham Offspring Study [poster presentation at the International Stroke Meeting, San Francisco, Feb 2007].

12. Jefferson AL, Au R, Massaro JM, Seshadri S, Beiser AS, Benjamin EJ, Gona P, Larson MG, O’Donnell C, Wolf PA, Manning W.  Aortic plaque and neuropsychological functioning in the Framingham Heart Study. [poster presentation at the 35th Annual meeting of the International Neuropsychological Society, Portland, OR, February 2007.

13. Blease S, Au R, Du Y, McKee A, Devine S, Rinn W, Dennison H, O’Connor M, Beiser A, Cabral H, Auerbach S, Seshadri S, Wolf PA, Kaplan E. Relating Clock drawing performance and Alzheimer’s Disease pathology in the Framingham Heart Study.[poster presentation at the35th Annual International Neuropsychological Meeting at Portland, OR, February 2007]

14. Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA. Is Declining Stroke Incidence due to Changes in Risk Factor Prevalence or Impact? Recalibrating the Framingham Stroke Risk Profile to Reflect Temporal Trends. [platform presentation at the International Stroke Meeting, San Francisco, Feb 2007].

15. Palumbo C, Beiser A, DeCarli C, Au R, Seshadri S, Wolf PA. Apolipoprotein E Modifies the Relationship of Brain MRI to Cognition: The Framingham Heart Study. [poster presentation at the American Academy of Neurology meeting, Boston, 2007].

16. Romero JR, Polak JF, Seshadri S, Beiser A, Benjamin EJ, Vasan RS, Wolf PA. Carotid Artery Atherosclerosis and Extracellular Matrix Remodeling: The Framingham Offspring Study. [platform presentation at the American Academy of Neurology meeting, Boston, 2007].

17. Paul CA, Au R, Freidman L, Massaro J, Seshadri S, Wolf PA. The effect of alcohol consumption on total brain volume: The Framingham Study. [poster presentation at the American Academy of Neurology meeting, Boston, 2007].

18. Seshadri S, Wolf PA, Beiser A, DeCarli C, Au R, Levy D, Larson MG, Vasan RS, Benjamin EJ, Mitchell GF. Arterial Stiffness and Measures of Brain Aging on Volumetric MRI and on Cognitive Testing: The Framingham Offspring Study. [poster presentation at the American Academy of Neurology meeting, Boston, 2007].

19. Au R, Beiser A, Seshadri S, Du Y, Cabral H, Auerbach S, DeCarli C, Wolf PA. Structural Brain Imaging Differentiates MCI Subtypes as early as middle age: Results from the Framingham Offspring Study. [platform presentation at the American Academy of Neurology meeting, Boston, 2007].

20. Poly CK, Au R, Jacques P, Massaro JM, Seshadri S, Wolf PA. Questionnaires in Relation to cognitive performance in the Framingham Offspring cohort. [poster presentation at the American Academy of Neurology meeting, Boston, 2007].

21. Albert M, Au R, Massaro JM, Seshadri S, Wolf PA, DeCarli C. Sex differences on brain MRI and cognition in Framingham Offspring study. [poster presentation at the American Academy of Neurology meeting, Boston, 2007].

22. Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser A, Murabito JM, Kelly-Hayes M, DeCarli C, Atwood LD, Wolf PA. Genetic Correlates of Brain Aging on MRI and Cognitive Test Measures: Genome Wide Association Analyses in the Framingham Heart Study. [platform presentation at the Contemporary Clinical Issues Plenary Session at the American Academy of Neurology meeting, Boston, 2007].

23. Petrea RE, Fears A, Feurestein J, Barest G, Seshadri S. Herpes simplex type 2 causing an atypical encephalitis presenting as a “stroke.” (2nd prize, clinical vignettes section, Massachusetts Medical Society Research Poster Meeting, Waltham, MA, April 2007].

24. Petrea RS, Romero JR, Seshadri S, Viereck JC, Babikian VL, Barest GD, Kase CS. Recurrent migraines with aura as an isolated presenting symptom of cerebral venous thrombosis. [poster presented at the European Stroke Conference, Glasgow, May 2007].

25. Tan ZS, Beiser A, Vasan RS, Au R, Kiel DP, Wolf PA, Seshadri S. Thyroid Stimulating Hormone and the Risk of Alzheimer’s disease. [platform presentation at the American Geriatric Society meeting, Seattle, WA, 2007].

26. Seshadri S, Beiser AS, Au R, Kelly-Hayes M, Kase CS, Wolf PA. Mild vascular cognitive impairment predicts risk of incident stroke in the Framingham study. [poster presentation at the VASCOG meeting, San Antonio, TX, 2007].

27. Romero JR, Beiser AS, Vasan RS, Benjamin EJ, Polak J, Wolf PA, Seshadri S. Carotid artery atherosclerosis, MRI indices of brain ischemia and aging and cognitive impairment: The Framingham study. [platform presentation at the VASCOG meeting, San Antonio, TX, 2007].

Ongoing Research Support

2 R01 AG16495-06A2 Wolf (PI) R01 AG16495 Wolf (PI) NIH/NIA 12/01/98-5/31/10

NIH/NIA MRI, Genetic and Cognitive Precursors of AD and Dementia Role: Investigator

The goals of the study are to relate risk factors for Alzheimer’s Disease (AD) and dementia in the Framingham Offspring and Omni cohorts to changes in brain morphology measured by Magnetic Resonance Imaging (MR) and cognitive performance. Longitudinal data on change in MRI and cognitive measures will enable us to further explore the hypothesis that CVRF prospectively ascertained during mid-life play an important role in progressive brain injury leading in turn to progressive decline in cognition, increasing the likelihood of mild cognitive impairment (MCI) or dementia in later life. Finally, we will combine extensive genetic information in younger individuals with a documented family history of dementia to explore potential early changes in brain structure and cognition that may be under genetic influence.

R01 AG08122 Wolf (PI) NIH/NIA 01/01/89-05/31/10

Epidemiology of Dementia in the Framingham Study Role: Investigator

The goals of the study are to expand cognitive surveillance efforts to the older FHS Offspring and multi-ethnic OMNI cohorts permitting us to explore the familial occurrence of AD and dementia and to relate mid-life habits and risk factors to incidence of AD and other types of dementia. More than 420 of these Offspring and OMNI subjects have volunteered as brain donors, and we plan to relate vascular pathology in the brain at autopsy to mid-life vascular risk factors measured over several decades. This study will permit us to address a key question of whether vascular risk factors, especially those present at midlife, increase the risk of clinical and pathological dementia generally, and AD specifically.

R01 NS17950 Wolf (PI) NIH/NINDS 12/01/81-06/30/09

Precursors of Stroke Incidence and Prognosis Role: Investigator

The study will further the understanding of the epidemiology of stroke through identification of newer risk factors and genetic influences. Clinical and subclinical strokes will be studied utilizing the rich multi-generational family-based structure. Clinical and subclinical strokes will be related to documented clinical stroke in parents and siblings to assess the impact of stroke risk factors depending on family history of stroke.

Pending Support

R01 (PI: Jacob Selhub) NIH/NIA 07/01/08-06/30/10

Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study

Role: PI of Framingham Subcontract

R01 (PI: Myriam Fornage) NIH/NHLBI

07/01/08-06/30/12

A genome-wide association study of ischemic brain vascular injury in ARIC

Role: PI of Framingham Subcontract

R01 (PI: Seshadri) NIH/NIA 07/01/08-06/30/12

Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging

Role: Principal Investigator

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