ISSN 2194-0479 ALTEX
LINZ 2018 ? EUSAAT 2018
Volume 7, No. 2 ISSN 2194-0479
(2018)
ALTEX Proceedings
Welcome
3D Models & Multi-OrganChips (MOC),
Human-Organ-Chips (HOC)
3R Centers in Europe
3Rs in Education and Academia
Advanced Safety Testing of Cosmetics and
Consumer Products
Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy
Biological Barriers
Disease Models Using Human Cells, Tissues and Organs
Ecotoxicology
Efficacy and Safety Testing of Drugs,
Medical Devices & Biopharmaceutics
Free Communications
LINZ 2018
21st European Congress on Alternatives to Animal Testing
EUSAAT 2018
18th Annual Congress of EUSAAT
eusaat-congress.eu
In Silico Models: Toxicology & Efficacy of Drugs, Chemicals & Cosmetics
International Progress in 3Rs Research
In Vitro Techniques for CNS Toxicity and Disease Studies
Refinement & Reduction
Replacement ? Advanced Technologies for Implementation of 3Rs
Specific Endpoints of Toxicity
Stem Cell Models (hiPS, ES, mES, miPS)
Update on Implementing EU Dir 63/2010
Vaccines & The 3Rs: New Methods and Developments (e.g. Batch Release Testing)
'Young Scientists' session
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Welcome address EUSAAT 2018
Abstracts Linz 2018
Dear friends and colleagues,
on behalf of EUSAAT, the European Society for Alternatives to Animal Testing, we welcome you to the 21st European Congress on Alternatives to Animal Testing & the 18th EUSAAT 3Rs congress in Linz, Austria on September 23-26, 2018.
During the past two decades the "Linz-Congress" has emerged in Europe as the major scientific event in the field of the 3Rs and in the year 2018 the EUSAAT 2018 3Rs Congress Linz will be the largest international 3Rs congress. We are particularly pleased that our international partner societies from China, CCARE, the Chinese Society for Alternatives to Animal Experiments, and from the USA, ASCCT, the American Society for Cellular and Computational Toxicology, are actively participating in our session on "International Progress in 3Rs Research".
EUSAAT 2018 is hosting oral and poster presentations to facilitate discussions and the exchange of ideas for the benefit of alternative methods to animal experiments. The Scientific Committee has identified the most important subjects related to the 3Rs that are currently of interest to scientists in Europe. The EUSAAT 2018 conference focuses in oral and poster sessions on Refinement and Reduction (e.g. animal welfare, education) as well as Replacement topics (e.g. disease models, non-animal tools for basic biomedical research, toxicity studies, omics techniques, advanced 3D models including recent progress in developing human-organ-chips).
After the success in 2016, this year we will host three round table discussions on topics that are of particular interest to EUSAAT members. The first on "International Progress in 3Rs Research", the second on "3R centers in Europe ? National and Local Centers" and the third on "Applying human 3D models and Multi-Organ-Chips (MOCs) in Industry".
We are grateful to all speakers for contributing to the training workshop "EUSAAT - Kirkstall Quasi Vivo? Training Workshop" and in particular to the company Kirkstall for the organization of this workshop, which is open to all participants of the EUSAAT 2018 congress.
In particular, we are very proud that we are able to continue the "Young Scientists Travel Award (YSTA)" program in 2018 and want to thank the SET Foundation for their generous funding. The YSTA program provides about 20 young scientists with the opportunity to share their ideas on the implementation of the 3Rs in education and novel test systems to reduce the suffering as well as the number of animals in research.
The EUSAAT Board is pleased that the number of sponsors of the EUSAAT congresses has increased over the years, since without their continuous support we would not be able to maintain the high scientific standard and to keep the congress fee low. Both elements are equally important in order to attract young scientists from all over Europe and beyond. Therefore, the EUSAAT Board and Scientific Committee thank all of the sponsors of EUSAAT 2018 on behalf of the participants.
Moreover, we are also pleased that the abstracts of the EUSAAT 2018 conference on the 3Rs are again published in ALTEX Proceedings and we thank the editor and CEO of ALTEX Edition for helping us to pave the way for future cooperation for the benefit of implementing the 3Rs in Europe.
We finally want to thank our colleagues on the EUSAAT Board and the Scientific Committee for their continuous support in planning the EUSAAT 2018 congress.
Horst Spielmann Secretary General
Winfried Neuhaus President
Dagmar Jirova Vice-President
Dominik R?nzler Vice-President
ALTEX Proceedings 7, 2/18
I
List of Abstracts
Abstracts Linz 2018
ID Title
Authors
Type
1
The elephant in the room: PREPARE
before you ARRIVE
Adrian Smith, R. Eddie Clutton, Elliot Lilley,
Oral
Kristine Hansen and Trond Brattelid
2
A combined in silico-3D lung tumor model to
Gudrun Dandekar, Meik Kunz, Sarah S. L. Nietzer, Oral
understand network effects of driver mutations for Florentin Baur, Michaela Baier, Claudia G?ttlich,
targeted therapy predictions
Julia Sch?ler, Ralf C. Bargou, Heike Walles and
Thomas Dandekar
3
S. aureus-infection-model at human liver-on-chip Fatina Siwczak, Alexander Mosig and
Lorena Tuchscherr de Hauschopp
Poster
4
Modelling ischemic stroke injury at the blood-brain Abraham Alahmad and Shyanne Page
Oral
barrier in vitro using induced pluripotent stem cells
5
Measuring Culture of Care ? a practical example Thomas Bertelsen
Oral
6
Development of an in-vitro testing battery to
assess biocompatibility of medical devices
Elisabeth Mertl, Christian Kirchnawy, Daniela Neubert, Elisabeth Riegel and Thomas Czerny
Poster
7
3Rs Centre in Sri Lanka to promote
"Replacement" concept
Stefanie Schindler, Mangala Gunatilake and
Oral
Francois Busquet
8
The Nonclinical Innovation and Patient Safety
Elizabeth Baker
Oral
Initiative (NIPSI): Supporting human-based
nonclinical approaches through advances in law,
policy, education and training in the United States
9
Using a concerted analysis of corresponding
Daniel Seitz and Florian Gaudig
Oral
cellular assays to create a complete in vitro
bone culture and implant testing system
10 Systematic assessment of well-being in mice for procedures using general anesthesia
Katharina Hohlbaum, Bettina Bert, Silke Dietze,
Oral
Heidrun Fink and Christa Th?ne-Reineke
11 Bioprinting perfusion-enabled liver equivalents
Tobias Grix
Oral
for advanced organ-on-a-chip applications
12 Comparative analysis of the difference of toxicity Mao Ling Wei, Bo Liu and Xin Mu
Oral
test between Chinese and European Pharmacopoeia
13 Tramadol: Paracetamol in drinking water to treat post-surgical pain in laboratory mice
Paulin Jirkof, Margarete Arras and Nikola Cesarovic Poster
14 Optimization of the Gluc-HET model
Renate Haselgr?bler, Flora St?bl, Marcus Iken, Klaus Schr?der and Julian Weghuber
Poster
15 Unique animal free 3D culturing of human cancer cells and normal cells
Atena Malakpour, Plaurent Rocci, Fredrik Johansson and Stina Oredsson
Poster
16 Meta-analysis of NTSs ameliorates identification of Bettina Bert, Barbara Grune, Daniel Butzke,
Oral
research areas for 3R development
Nora Leich, Antje Doerendal, Justyna Chmielewska,
Julia Vietze and Gilbert Sch?nfelder
18 Focus on severe suffering: How reducing
Elliot Lilley
Oral
suffering can be a gateway to replacement
19 A dynamic model of the alveolar interface
Roberta Nossa and Arti Ahluwalia
Oral
for the study of aerosol deposition
ALTEX Proceedings 7, 2/18
II
Abstracts Linz 2018
ID Title
Authors
Type
21 In silico tools to assist the development of physiologically-based kinetic models: Identification, characterisation and use
Judith Madden, David Ebbrell, Alicia Paini and
Oral
Mark Cronin
22 Computational methods for the prediction of chemical toxicity
Priyanka Banerjee and Robert Preissner
Oral
23 A human epidermal burn wound model as alterna- Verena Schneider, Ives Bernardelli de Mattos,
tive for animal testing
Martin Funk, Heike Walles and Florian Groeber-
Becker
Poster
24 Methodological improvements and automation for Karma Fussell, Julie Mollergues, Maricel Marin-
Oral
better biodetection of endocrine activities in-vitro Kuan, Gabriele Scholz and Benoit Schilter
25 Modelling Alzheimer's disease in threedimensional human neural progenitor cultures
Carine Gaiser, Anna Weston and Laura Suter-Dick Poster
26 Implementing the 3Rs into ecological research
Miriam A. Zemanova
Poster
28 Systems toxicology assessment of a 72-hour
Filippo Zanetti, Alain Sewer, Bjorn Titz,
repeated exposure to Swedish snus extract and total Anita R. Iskandar, Athanasios Kondylis,
particulate matter from 3R4F cigarette smoke on
Laura Ortega Torres, Claudius Pak, Florian
gingival organotypic cultures
Martin, Emmanuel Guedj, Ashraf Elamin,
Keyur Trivedi, Stefan Frentzel, Nikolai V.
Ivanov, Julia Hoeng and Manuel C. Peitsch
Poster
30 Persistent endocrine-disrupting chemicals found
Justyna Gogola, Marta Hoffmann and Anna Ptak
Oral
in human follicular fluid stimulate proliferation of
granulosa tumor via IGF1R ? 3D cell culture model
31 Evaluation of retinoic acid receptor alpha (RAR) Barbara Birk, Philipp Demuth, Nadine Roth,
Oral
interaction of chemicals by combining two
Katharina Maria Sessler, Hans-Albrecht Huener,
techniques to a new screening approach
Andreas Verlohner, Burkhard Flick, Robert
Landsiedel and Bennard van Ravenzwaay
32 Metabolome analysis in vitro in NRK-52e cells
Barbara Birk, Saskia Sperber, Hans-Albrecht
Oral
might allow the prediction of nephrotoxicity
Huener, Andreas Verlohner, Svenja Wallisch,
and its mode of action
Tilmann Walk, Volker Haake, Michael Spitzer,
Hennicke Kamp and Bennard van Ravenzwaay
33 Reverse dosimetry approaches for potential endocrine disruptors
Eric Fabian, Amelie Ochs, Christian Haase, Caroline Gomes, Barbara Birk, Tzutzuy Ramirez, Rene Zbranek, Bennard van Ravenzwaay and Robert Landsiedel
Poster
35 Non-animal methods for skin sensiti-
David Roberts
Oral
sation testing ? is there really a need
for integrated testing strategies?
36 Emulating the gut-liver axis ? organ-on-chip as translational tool in sepsis research
Michelle Maurer, Tony Wollny, Florian Berlinghof, Oral Otmar Huber and Alexander Mosig
37 The horse as model for osteoarthritis
Annemarie Lang and Timo Gaber
Oral
research ? research tools vs. stakeholders
38 Sharing is caring ? update on innovative
Annemarie Lang
Oral
approaches to share organs and tissues
to reduce the lab animal usage
40 EFPIA ? putting animal welfare principles and 3Rs into action
Thomas Bertelsen, Kirsty Reid and Chris Petursson Poster
41 The Danish National Committee for the protection Rasmus Normann Nielsen of animals used for scientific purposes
Poster
III
ALTEX Proceedings 7, 2/18
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