XV - UT Southwestern



Curriculum vitaeDate Prepared:July 30, 2012Name:Olga Theresa (Hardy) Gupta, M.D.Office Address:5323 Harry Hines Blvd., Dallas, TX 75390-9063Work Phone: 214-648-3501Work E-Mail: olga.gupta@utsouthwestern.eduWork Fax:214-648-9772Place of Birth:Silver Spring, MDEducationYearDegree(Honors)Field of Study(Thesis advisor for PhDs)Institution1992-1996B.S. (cum laude)Biomedical EngineeringDuke University, Durham, NC1996-2000M.D.University of California, San Francisco, CA2008-2010M.S.Clinical Investigation (Michael Czech, PhD)University of Massachusetts Medical School, Worcester, MAPostdoctoral Training [Include residency/fellowship]Year(s)TitlesSpecialty/Discipline(Lab PI for postdoc research)Institution2000-2003ResidentPediatricsDuke University, Durham, NC2003-2006FellowPediatric Endocrinology ( Klaus Kaestner, PhD)The Children’s Hospital of Philadelphia, Philadelphia, PACurrent Licensure and CertificationLicensure Physician, Texas and MassachusettsBoard and Other Certification Pediatrics 2003; Pediatric Endocrinology, 2008Honors and AwardsYearName of Honor/AwardAwarding Organization2001Primary Care Certificate of ExcellenceDuke Children’s2003Billie Wright Adams, M.D. Scholar, Pediatrics SectionNational Medical Association2005-2006Research Fellowship GrantLawson Wilkins Pediatric Endocrine Society2005First Place PosterNational Cooperative Growth Study, Genentech2006Outstanding Patient-Oriented Research Poster Institute for Diabetes, Obesity and Metabolism Spring Symposium and Kroc Lecture2009Best paper published in 2008 in the section “Novel Insights from Clinical Practice”Hormone Research2010Poster AwardTranslational Medicine and Science Retreat2011Poster AwardTranslational Medicine and Science Retreat2012Dedman Family Scholar in Clinical CareUniversity of Texas SouthwesternFaculty Academic AppointmentsYear(s)Academic TitleDepartmentAcademic Institution2006-2007InstructorPediatricsUniversity of Pennsylvania School of Medicine, Philadelphia, PA2007-2012Assistant ProfessorPediatricsUniversity of Massachusetts Medical School, Worcester, MA2012-presentAssistant ProfessorPediatricsUniversity of Texas Southwestern Medical Center, Dallas, TXAppointments at Hospitals/Affiliated InstitutionsPastYear(s)Position TitleDepartment/DivisionInstitutionCurrentYear(s)Position TitleDepartment/DivisionInstitutionOther Professional Positions [Industry, foundation, private practice]Year(s)Position TitleInstitution2006-2007Medical DirectorADA Donovan McNabb Diabetes Camp, Green Lane, PA2007-2012Medical DirectorBarton Diabetes Camp, Oxford, MAMajor Administrative/Leadership Positions [Do not include Professional Society positions]Year(s)Position TitleInstitutionCommittee Service (Member, unless noted otherwise) [Do not include Professional Society positions]Year(s)Name of CommitteeInstitution/OrganizationUTSW2009-2010Faculty Forward, a task force designed to improve faculty satisfaction and retentionUniversity of Massachusetts Medical School,Worcester, MAHospitalState/Regional2009-2012Medical Advisory CommitteeClara Barton and Joslin Diabetes CampsNational/InternationalProfessional Societies [List all society committees, leadership, and course leadership roles here]DatesSociety Name, member2000-2003American Academy of Pediatrics2003-2006American Association of Clinical Endocrinologists2003-presentThe Endocrine Society2003-presentAmerican Diabetes Association2003-presentPediatric Endocrinology SocietyCommittees FellowshipsGrant Review ActivitiesYear(s)Name of Review CommitteeOrganizationEditorial ActivitiesYear(s)Journal NameEditor/Associate EditorEditorial BoardAd Hoc ReviewerGrant Support PresentGrantor: National Institutes of HealthTitle of Project: Pet ownership and diabetes management: Evaluation of the impact of responsible pet ownership on glycemic control in youth with type 1 diabetes mellitusRole (Principal Investigator, Co-Investigator):Co-InvestigatorAnnual amount and date (direct costs only):Total amount of award (if multi-year) and dates (direct costs only): 1/15/2012-12/31/2013 $100,000 directPastGrantor: Center for Clinical and Translational Science, University of Massachusetts Medical SchoolTitle of Project: Capacity Building at GoKids Boston, An Intercampus Initiative:Evaluation of the effects of a multicomponent wellness intervention designed for inner-city high school students on metabolic parametersRole (Principal Investigator, Co-Investigator):Co-InvestigatorAnnual amount and date (direct costs only):Total amount of award (if multi-year) and dates (direct costs only): $150,000 10/01/09-9/30/2011PastGrantor: Center for Clinical and Translational Science, University of Massachusetts Medical SchoolTitle of Project: Adipose tissue inflammation and insulin resistance: Evaluation of genetic and histologic traits that correlate with insulin resistance in morbid obesity in adults undergoing gastric bypass surgeryRole (Principal Investigator, Co-Investigator):Co-InvestigatorAnnual amount and date (direct costs only):Total amount of award (if multi-year) and dates (direct costs only): 07/01/07-03/15/12$125,000 directPastGrantor: Diabetes and Endocrinology Research Center, University of Massachusetts Medical SchoolTitle of Project: Innate immunity and metabolism: Evaluation of the role of inflammation in the metabolic sequelae associated with childhood obesityRole (Principal Investigator, Co-Investigator):Principal InvestigatorAnnual amount and date (direct costs only):Total amount of award (if multi-year) and dates (direct costs only): 04/01/09-03/15/12$100,000Clinical Trials ActivitiesPresentGrantor:Title of Project:Role (Principal Investigator, Co-Investigator):PastGrantor:Title of Project:Role (Principal Investigator, Co-Investigator):Teaching ActivitiesYear(s)ActivityMedical and graduate school didactic and small group teaching2009-2012Building Working Cells and Tissues (FOM1), lecture on Diabetes and Metabolism (1 hr/yr), 114 students 2008-2012Pediatrics Clerkship, lecture on Normal and Abnormal Growth Patterns in Childhood (9 hr/yr)2008-2012Clinical and Translational Research Pathway, Journal Club Course DirectorDissertation committeesQualifying examination committeesCommittees concerned with medical and graduate student educationGraduate student rotationsMedical student rotationsGraduate student trainees2008-2012Advising of Zheni Gjoka (4th year medical student), Sabine Schnyder (third year pediatrics resident), William Zawatski (second year pediatrics resident), Nasim Gorji (first year pediatrics resident)Postgraduate medical education (graduate & continuing medical education)Postdoctoral traineesInvited Lectures Year(s)TitleLocationInternational2005Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. European Society of Paediatric Endocrinology /Lawson Wilkins Pediatric Endocrine Society. Joint Meeting. Lyon, France.2006Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. Lawson Wilkins Pediatric Endocrine Society. Toronto, Canada. 2007Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. Congenital Hyperinsulinism International Conference, Philadelphia, PA.National2005Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. Endocrine Society 88th Annual Meeting, Boston2009Hypoglycemia in the neonate. New England Pediatric Nursing Organization, Woodstock, VT 2011Role of inflammatory monocytes in adolescent metabolic syndrome. Pediatric Academic Society, Denver, CO2011Activated innate immunity in childhood: a novel treatment target. Translational Medicine Conference, Worcester, MARegional/LocalFunctional genomic analysis of insulin secretion using RNA interference. Department of Genetics. Postdoctoral Fellow and Graduate Student Research Talk. Philadelphia, PA.2005Localization of focal lesions of congenital hyperinsulinism using 18 f-labeled L-fluoro dopa. Philadelphia Endocrine Society. Endocrine Fellows Presentation. Philadelphia, PA.2005Fatty acids and insulin secretion: from bedside to bench. Department of Genetics. Postdoctoral Fellow and Graduate Student Research Talks, Philadelphia, PA.2006Spoonful of sugar helps the medicine go down … hypoglycemia in the neonate. Pediatric Grand Rounds. University of Massachusetts Medical Center.2007Diabetes … new approaches and equipment. Pediatric Grand Rounds. Milford Regional Medical Center. Milford, MA.2008Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Hyperinsulinemic hypoglycemia following gastric bypass: pathogenesis and treatment symposium. Joslin Diabetes Center. Boston, MA2008Computational genomics approach to insulin resistance and obesityDiabetes and Endocrinology Research Center Retreat, Shrewsbury, MA2009Role of the monocyte/macrophage cell lineage in obesity-related insulin resistance. UMMS 15th Annual Research Retreat, Woods Hole, MA2010Innate immunity and metabolic disease. Touchstone Diabetes Center Conference, Dallas, TX2011Gestational weight gain impacts child adiposity and metabolic disease. Community of Scholars, Worcester, MA2011ABCs of Type 1 Diabetes Mellitus Care in the Community. Diabetes Day for School Nurses, Worcester, MATechnological and Other Scientific InnovationsInnovationPatent, if any, pending or awarded /If described in print/on web, provide citationService to the Community Year(s)RoleOrganization or institution May include a brief, one-sentence description of each role if needed (optional)Bibliography Peer-Reviewed Publications (List in chronological order with complete pagination. Authors should be listed in the same order as they appear in the published article. Original Research ArticlesHardy O, Yan A, Grimberg A. PTU-associated vasculitis in a girl with Turner’s syndrome and Graves disease. Pediatr Emerg Care. 22:52-54 (2006).Peranteau WH, Bathaii SM, Pawel B, Hardy O, Alavi A, Stanley CA, Adzick NS. Multiple ectopic lesions of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism. J Pediatr Surgery. 1:188-192(2007).Hardy O, Pampaloni M, Suchi M, Ruchelli E, Zhuang H, Ganguly A, Saffer J, Freifelder R, Adzick NS, Alavi A, Stanley C. Diagnosis and localization of focal congenital hyperinsulinism by 18F- fluorodopa PET scan. J Peds. 2:140-145 (2007).Hardy OT, Hohmeier H, Becker T, Doliba N, Gupta R, White P, Manduchi E, Stoeckert C, Matschinsky F, Newgard C, Kaestner K. Functional genomics of the β-cell: SCHAD regulates insulin secretion independent of K+ currents. Molecular Endocrinology. 3:765-773 (2007).Gupta R, Gorski R, White P, Hardy OT, Rafiq K, Brestelli J, Chen G, Stoeckert C, Kaestner K. Expansion of adult β -cell mass in response to increased metabolic demand is dependent on HNF-4a. Genes and Development. 7:756-769 (2007).Hardy OT, Hernandez-Pampaloni M, Saffer JR, Scheuermann JS, Ernst LM, Freifelder R, Zhuang H, MacMullen C, Becker S, Adzick NS, Divgi C, Alavi A, Stanley CA. Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.J Clin Endocrinol Metab. 12:4706-4711 (2007).Mohnike K, Blankenstein O, Pfuetzner A, P?tzsch S, Schober E, Steiner S, Hardy OT, Grimberg A, van Waarde WM. Long-term non-surgical therapy of severe persistent congenital hyperinsulinism with glucagon. Hormone Research. Horm Res. 1:59-64 (2008).Nwosu, BU, Soyka LA, Angelescu A, Hardy OT, Lee MM. Is Multifetal Pregnancy a Risk Factor for Maternal and Neonatal Vitamin D Deficiency? The Endocrinologist. 18:172-175 (2008).Nwosu BU, Hardy OT, Angelescu A, Soyka L, Lee MM. Do Atypical Antipsychotic Agents Trigger Autoimmune Diabetes in Adolescents? The Endocrinologist. 19:2 (2009).Fitzgibbons T, Hardy OT, Lessard D, Gore JM, Yarzebski J, Goldberg RJ. Body Mass Index, Treatment Practices, and Mortality in Acute Heart Failure. Archives of Internal Medicine. Coronary Artery Disease. 8:536-543 (2009).Hardy OT, Perugini RA, Nicoloro SM, Gallagher-Dorval K, Puri V, StraubhaarJ, Czech MP. BMI-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surgery for Obesity and Related Disorders. 1:60-67(2011).Hardy, OT, Wiecha J, Kim A, Salas C, Briceno R, Moody K, Becker J, Glazer G, Ciccarelli C, Shi L, Hayman LL. (2012). Effects of a multicomponent wellness intervention on dyslipidemia among overweight adolescents. J Pediatr Endocrinol Metab. 25(1-2):79-82.Hardy OT, Czech MP, Corvera S. (2012). What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes. Apr;19(2):81-7.Reviews, Chapters, Monographs and Editorials Books/TextbooksHardy O, Kelly A. The 5-Minute Pediatric Consult. Premature Thelarche. Fourth Edition. Lippincott Williams & Wilkins. Philadelphia, PA. (2005).Hardy O, Stanley C. PET for localization of focal forms of hyperinsulinism of infancy. Pediatric PET Imaging. Springer. New York. (2006).Hardy O, Stanley C. Fetal and Neonatal Physiology. Hypoglycemia. Elsevier. Missouri. In press.Case ReportsLetters to the EditorProceedings of MeetingsClinical Practice GuidelinesNon-peer reviewed scientific or medical publications/materials in print or other mediaHardy O, Worley G, Lee MM, Chaing S, Mackey J, Crissman B, Kishnani PS. Hypothyroidism in Down syndrome: Screening guidelines and testing methodology. American Journal of Medical Genetics Part A 2003; June 30 (4):436-437.Hardy O, Litman R. Congenital hyperinsulinism. A review of the disorder and a discussion of the anesthetic management. Pediatric Anesthesia. 2007 Jul;17(7):616-21 ................
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