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Cleveland Clinic Neurological Institute and Genomic Medicine InstituteEpilepsy Genetics Update 2020State-of-the-Art Updates on Gene-informed Medical ManagementLive-streamed September 11-13, 2020About the UpdateIn the past decade, genomics research has led to the identification of more than 100 epilepsy-associated genes that can be clinically tested. With the opportunity to identify the genetic etiology of a patient’s epilepsy, clinicians will be confronted with new decisions regarding patient selection, which genetic test to choose, interpreting the results, and tailoring the treatment using existing drugs and interventions. Educating patients and families about possible outcomes, limitations of genetic testing, and the emergence of gene-disorder family foundations are also at the forefront.?Target AudienceThe program content is appropriate for practicing neurologists, epileptologists, pediatric neurologists, genetic counselors specialized in epilepsy.ObjectivesAt the completion of this activity, the participant should be able to:Review the role of genetics in treating epilepsyDiscuss methods of genetic testing in epilepsy and genetic test interpretationDiscuss the clinical significance of genetic testingReview case-based illustrations of genetic testing use in diagnostics and patient managementDiscuss the role of community, including patient-based organizations, in raising awareness of genetic testing in epilepsyReview genetic-based pharmacological intervention in treating epilepsyDisclaimerThe information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.AccreditationThe Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.The Cleveland Clinic Foundation Center for Continuing Education designates this internet live activity for a maximum of 17.0 AMA PRA Category 1 Credits?. Physicians should claim only the credit commensurate with the extent of their participation in the activity.Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.Other Health Care Professionals?- A certificate of participation will be provided to other health care professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations.Copyright 2020 The Cleveland Clinic Foundation. All Rights Reserved.Cleveland Clinic Neurological Institute and Genomic Medicine InstituteEpilepsy Genetics Update 2020Live-Streamed State-of-the-Art Updates on Gene-informed Medical ManagementSeptember 11-13, 2020HOW TO OBTAIN AMA PRA CATEGORY 1 CREDITS? OR CERTIFICATE OF PARTICIPATION:*Note - The ability to claim CME credit will be available by Friday, September 18, 2020. A notification will be sent to all participants with the link and instructions for obtaining the certificate. Go to cmelogin to begin the activity evaluation and print your certificate. You have 30 days following the activity to claim credit.New Users: By attending this activity, an account has been created for you. Please follow these steps:Click on ‘Reset Password.’Enter email address used for registration.Click on ‘Request Password Reset.’You will receive an email to reset your password.Existing Users:Enter email address used for registration.Enter password.9810759398000Select, and complete all questions. Select the number of credits you are claiming by either using (a) the drop-down OR (b) checking the box marked ‘maximum available.’Click ‘Save and View Certificate.’Your official certificate will be displayed. Please print and keep with your permanent files. You may also access your account at any time to view and/or print CME certificates and transcripts. ** If you need assistance, contact the CME office at 216.444.9990 or myCME@. Cleveland Clinic Neurological Institute and Genomic Medicine InstituteEpilepsy Genetics Update 2020Live-Streamed State-of-the-Art Updates on Gene-informed Medical ManagementSeptember 11-13, 2020Course DirectorsDennis Lal, PhDImad Najm, MDCleveland Clinic Cleveland ClinicKeynote SpeakerCharis Eng, PhDDepartment ChairCleveland Clinic Genomic InstituteGuest FacultyMelanie Bahlo, PhDThe Walter and Eliza Hall Institute of Medical Research Victoria AustraliaKevin Bender, PhDUniversity of California San Francisco San Francisco, CA Andreas Brunklaus, MDRoyal Hospital for Children Glasgow Glasgow, UKOrrin Devinsky, MDNYU Langone Health New York, NYAndrew Escayg, PhDEmory UniversityAtlanta, GA Amber Freed SLC6A1 ConnectDenver, CO Alfred George, MDNorthwestern University Feinberg School of MedicineChicago, ILHeidi Grabenstatter, PhDInternational Foundation for CDKL5 Research Wadsworth, OH Veronica Hood, PhDDravet Syndrome Foundation Cherry Hill, NJJennifer Kearney, PhDNorthwestern UniversityChicago, ILJohannes Lemke, MDUniversity of LeipzigLeipzig, Germany Miriam Meisler, PhDUniversity of MichiganAnn Arbor, MI John Millichap, MDNorthwestern UniversityChicago, ILAna Mingorance, PhDLoulou FoundationLondon, UK Heather Olson, MDBoston Children's HospitalBoston, MA Annapurna Poduri, MD, MPHBoston Children's Hospital Boston, MA Leah Schust, FamilieSCN2A Longmeadow, MARikke Steensbjerre Moller, PhD, MScDanish Epilepsy Centre/University of Southern Denmark Odense, DenmarkStephen Traynelis, PhDEmory University Atlanta, GAVicky Whittemore, PhDNational Institutes of HealthBethesda , MDCleveland Clinic FacultyDavid Flannery, MDAjay Gupta, MDCostin Leu, PhDSumit Parikh, MDEduardo Pérez Palma, PhDElia Pestana-Knight, MDAllison Schreiber, MS, CGCModeratorsTobias Bruenger Noah DubasikMarie GrammCostin LeuJavier LopezEduardo Perez-PalmaPlanning CommitteeDennis Lal, PhDImad Najm, MDArthur Stefanski, BA Cleveland Clinic Neurological Institute and Genomic Medicine InstituteEpilepsy Genetics Update 2020Live-Streamed State-of-the-Art Updates on Gene-informed Medical ManagementSeptember 11-13, 2020Friday, September 112:00-2:15 pmWelcome Moderator: Dennis Lal2:15-3:00 pmKeynote Presentation – PTEN-opathies: From Research to Clinical Care – Charis Eng 3:00-3:30 pmBREAKModerators: Dennis Lal and Arthur Stefanski3:30-4:00 pmReview State and Promise of Genetics in Clinical Epilepsy/practice – Dennis Lal 4:00-4:30 pmEpilepsy Genetics – The NIH/NINDS perspective – Vicky Whittemore4:30-6:00 pmGenetic test selection and interpretation Allison Schreiber - Molecular Testing for Epilepsy: Genetic Counseling Considerations David Flannery - Digital Transformation of Clinical Genetic Services Delivery Saturday, September 12Moderators: Marie Gramm, Eduardo Perez-Palma, Dennis Lal9:00-10:30 amGenotype-phenotype correlation studies and tailored treatment for the most common monogenic epilepsies- Part 1Andreas Brunklaus: Genotype-phenotype correlation studies and tailored treatment for the most common monogenic epilepsies: SCN1ARikke Steensbjerre Moller: Genotype-phenotype Correlation Studies and Tailored Treatment for the Most Common Monogenic Epilepsies: SCN2A/SCN8AJohannes Lemke: GRIN Genes10:30-11:00 amBREAKModerators: Eduardo Perez-Palma, Arthur Stefanski, Dennis Lal 11:00-12:30 pmGenotype-phenotype correlation studies and tailored treatment for the most common monogenic epilepsies - Part 2John Millichap: Genotype-phenotype Correlation Studies and Tailored Treatment for the Most Common Monogenic Epilepsies: KCNQ2Heather Olson: Genotype-phenotype Analysis in Epilepsy: CDKL5 Deficiency DisorderAjay Gupta: Genotype-Phenotyp Correlation and Therapeutic Implications: An mTOuR of Tuberous Sclerosis Complex and Epilepsy12:30-2:00 pmBREAKModerators: Costin Leu, Noah Dubasik, Dennis Lal2:00-4:00 pmOther types of genetic epilepsies Sumit Parikh: Dz & Epilepsy: The BasicsAnnapurna Poduri: Somatic Mutation and Mosaic Variants in EpilepsyMelanie Bahlo: Identification of Repeat Expansions with Whole Exome and Whole Genome Sequencing in Epilepsy PatientsElia Pestana Knight: EEG in Infantile Genetic EpilepsiesModerators: Eduardo Perez-Palma, Arthur Stefanski, Dennis Lal4:00-6:00 pmPatient support through gene level family organizations Heidi Grabenstatter: The International Foundation for CDKL5 Research: A History Veronica Hood: Dravet Syndrome Amber Freed: Maxwell’s Story:SLC6A1Leah Schust: The Power of the One to Inspire the Many: The Power of the Many to Cure the OneCleveland Clinic Neurological Institute and Genomic Medicine InstituteEpilepsy Genetics Update 2020Live-Streamed State-of-the-Art Updates on Gene-informed Medical ManagementSeptember 11-13, 2020Sunday, September 13Moderators: Javier Lopez, Tobias Bruenger, Dennis Lal9:00-10:30 amMolecular studies of genes associated with epilepsies – Part 1Kevin Bender: Neurodevelopmental Effects of SCN2A Loss of FunctionJennifer Kearney: Mouse Models of Genetic Epilepsies Stephen Traynelis: Molecular Studies of Genes Associated with Epilepsies: GRIN Gene Family (NMDA Receptors) Alfred George: Molecular Studies of Genes Associated with Epilepsies: KCNQ210:30-11:00 amBREAKModerators: Javier Lopez, Tobias Bruenger, Dennis Lal11:00-12:30 pmMolecular studies of genes associated with epilepsies – Part 2Andrew Escayg: SCN1A Epilepsy: New Treatments Costin Leu: Polygenic Epilepsies Eduardo Perez-Palma: Similarity Among Epilepsy Genes 12:30-2:00 pm BREAKModerators: Dennis Lal, Costin Leu 2:00-5:30 pmAvailable and future gene-based therapies in epilepsyOrrin Devinsky: Epilepsy Therapeutics for Genetic Epilepsies Ana Mingorance: Epilepsy Therapeutics in Development Miriam Meisler: Antisense Oligonucleotide (ASO) Treatment in Epilepsy Imad Najm : Epilepsy Surgery Genetics – Are we there yet?5:30 pmWrap Up & AdjournDennis LalA five-minute question and answer period is included in each speaker’s allotted time.The Cleveland Clinic Center for Continuing EducationFaculty DisclosureEpilepsy Genetics Update 2020 State-of-the-Art Virtual Updates on Gene-informed Medical Management09/11-13/2020In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.The following faculty have indicated that they may have a relationship, which in the context of their presentation(s), could be perceived as a potential conflict of interest:Andreas Brunklaus, MDBiocodexTeaching and SpeakingZogenixTeaching and SpeakingGW PharmaTeaching and SpeakingNutriciaTeaching and SpeakingEncoded TherapeuticsMembership on advisory committee or review panels Teaching and SpeakingOrrin Devinsky, MDTevard Biosciences, IncScientific and Business BoardsOwnership interest (stock, stock options)Regal BiosciencesScientific and Business BoardsOwnership interest (stock, stock options)RETTCO, IncScientific and Business BoardsOwnership interest (stock, stock options)Script BiosciencesScientific and Business BoardsOwnership interest (stock, stock options)Ajay Gupta, MDEisaiConsultingJohn Millichap, MDNIHResearch / Independent ContractorCitizens United for Research in Epilepsy (CURE)Research / Independent ContractorUCBConsultingResearch / Independent ContractorDisruptive NutritionConsultingResearch / Independent ContractorXenonConsultingResearch / Independent ContractorIonis PharmaceuticalsConsultingESAIConsultingMembership on advisory committee or review panels SareptaConsultingBioMarinTeaching and SpeakingGreenwich BiosciencesTeaching and SpeakingSunovionTeaching and SpeakingMallinckrodt Inc. Teaching and SpeakingAmerican Academy of Neurology (AAN)Editorial honorariaUpToDate, Inc.Editorial honorariaAnnapurna Poduri, MDGenzyme/SanofiSpouse is employed by companyThe following faculty have indicated they have no relationship which, in the context of their presentation(s), could be perceived as a potential conflict of interest: Melanie Bahlo, PhDKevin Bender, PhDTobias Bruenger, MDNoah Dubasik, BSCharis Eng, MDAndrew Escayg, PhDDavid Flannery, MDAmber Freed, N/AAlfred George, MDHeidi Grabenstatter, PhDMarie Gramm, MSVeronica Hood, PhDJennifer Kearney, PhDDennis Lal, PhDJohannes Lemke, MDCostin Leu, PhDJavier Lopez Rivera, BSNMiriam Meisler, PhDAna Mingorance, PhDImad Najm, MDHeather Olson, MDSumit Parikh, MDEduardo Perez Palma, PhDElia M Pestana Knight, MDAllison Schreiber, MSLeah Schust, N/ARikke Steensbjerre Moller, PhDArthur Stefanski, BAStephen F Traynelis, PhDVicky Whittemore, PhDCleveland Clinic Neurological Institute and Genomic Medicine InstituteEpilepsy Genetics Update 2020Live-Streamed State-of-the-Art Updates on Gene-informed Medical ManagementSeptember 11-13, 2020The Cleveland Clinic Foundation Center for Continuing Education acknowledges educational grants for partial support of this activity from:Eisai Inc.UCB, Inc.SK Life Science, Inc.Encoded Therapeutics, Inc. ................
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