LAUREN CHRISTINE FREY



CURRICULUM VITAE

LAUREN CHRISTINE FREY, M.D.

Associate Professor- Department of Neurology

Education:

Harvard University - Cambridge, Massachusetts

• B.A. in Biology, 1992

• Graduated Magna cum laude

University of Alabama School of Medicine - Birmingham, Alabama

• M.D., 1997

• Graduated Cum laude

Internship, Internal Medicine - University of Colorado Denver

• Denver, Colorado

• 1997-1998

Residency, Neurology - University of Colorado Denver

• Denver, Colorado

• 1998-2000

Chief Resident, Neurology - University of Colorado Denver

• Denver, Colorado

• 2000-2001

Fellow, Epilepsy/ EEG- Columbia University Comprehensive Epilepsy Center

• New York, New York

• July 2001- June 2003

University of Colorado School of Medicine Teaching Scholars’ Program

• Denver, Colorado

• 2011-2012

Neurofeedback Certification Training Program

• Denver, Colorado

• 2011-2013

Academic Appointments:

Instructor – Department of Neurology, University of Colorado Denver

• Denver, Colorado

• January 2004- June 2006

Assistant Professor – Department of Neurology, University of Colorado Denver

• Denver, Colorado

• July 2006- July 2013

Associate Professor – Department of Neurology, University of Colorado Denver

• Denver, Colorado

• July 2013- Present

Faculty Associate- Colorado Injury Control and Research Center, Colorado State University

• Fort Collins, Colorado

• September 2008- December 2012

Honors, Special Recognitions and Awards:

1990, 1991, 1992 Harvard College Scholarship Award for Academic Achievement

1990, 1991, 1992 Elizabeth Cary Agassiz Certificate of Merit - Harvard University

1996- Present Member, Alpha Omega Alpha Honor Society

1997 Janet M. Glasgow Memorial Citation for Scholastic Achievement - UASOM

1997 Award for Exemplary Academic Performance – UASOM

2010 Recipient of 2010 Department of Neurology Faculty Teaching Award

2011- 2012 University of Colorado SOM Teaching Scholars’ Program

2012- 2013 Chair, Professional Advisory Board, Epilepsy Foundation of Colorado

2016 Elected Fellow of the American Epilepsy Society

Professional Organizations and Affiliations:

1998- Present American Academy of Neurology

2004- Present American Epilepsy Society

2008- 2013 American Clinical Neurophysiology Society

2009- Present Clinical and Translational Sciences Institute, University of Colorado, Denver

2009- 2011 Faculty Affiliate- Neuroscience Training Program, University of Colorado, Denver

2011- Present Center for NeuroScience, University of Colorado, Denver

2011- 2014 Society for the Advancement of Brain Analysis

2011- Present International Society for Neurofeedback and Research

Major Committee and Service Responsibilities:

University of Colorado School of Medicine:

2009- Present Department of Neurology- Epilepsy Fellowship Program Director

2010- Present Department of Neurology- Residency Program and Clinical Competency Committees

2010- 2014 School of Medicine Admissions Committee

2011- 2013 Department of Neurology- Epilepsy Didactic Block Director

2014- Present Department of Neurology- Director, Research Arm, LEAdR Program

2014- Present School of Medicine- Faculty Promotions Committee

2015- Present Faculty Resilience Council Committee Member

2015- Present Chair, Steering Committee, Peer-to-Peer Network Support Program

Hospital:

2009- 2014 Associate Medical Director, Epilepsy Monitoring Unit, University of Colorado

Hospital

2012- Present Director, Neurofeedback Clinic, University of Colorado Hospital

2014- Present Medical Director, Epilepsy Monitoring Unit, University of Colorado Hospital

2015- Present Member, Neuroscience Committee, University of Colorado Hospital

Community:

2005- 2015 Epilepsy Foundation of Colorado- Professional Advisory Board Member

2011- 2012 Epilepsy Foundation of Colorado- Chair-Elect, Professional Advisory Board

2012- 2013 Epilepsy Foundation of Colorado- Chair, Professional Advisory Board

2013 Faculty- Helmet Heads Program, Aurora Public Schools

National/ International:

2007- 2010 American Epilepsy Society- Scientific Program Committee

2007- 2010 American Epilepsy Society- Web Content Subcommittee

2011- 2013 American Epilepsy Society- Treatments Committee

2011- Present American Epilepsy Society- Content Development Committee

2012- 2015 Co-Chair, American Epilepsy Society- Special Interest Group “Behavioral Interventions”

2013- Present American Epilepsy Society- Content Development Committee Workgroup Chair

2014- Present American Epilepsy Society- Scientific Program Committee

2014- Present American Epilepsy Society- CME Review Committee

2015- Present International Society for Neurofeedback Research- Scientific Program Committee

2015- Present International Society for Neurofeedback Research- Ethics Committee

2016- Present American Epilepsy Society- Content Development Committee Vice Chair

Licensure and Board Certification:

2000- Present State of Colorado

2001- 2005 State of New York

2002- Present Diplomate, American Board of Psychiatry and Neurology (Neurology)

2009- Present Diplomate, American Board of Clinical Neurophysiology, with special

competency in Epilepsy Monitoring

2013- Present Diplomate, American Board of Psychiatry and Neurology (Epilepsy Subspecialty)

2013- Present Diplomate, Biofeedback Certification International Alliance (Neurofeedback)

Review and Referee Work:

2006- Present Ad-hoc reviewer, European Journal of Neurology

2008- Present Ad-hoc reviewer, Pediatrics

2008- Present Ad-hoc reviewer, Epilepsy Research- awarded Recognized Reviewer status (2014)

2009- Present Ad-hoc reviewer, Epilepsia

2011- Present Ad-hoc reviewer, Canadian Medical Association Journal

2012- Present Ad-hoc reviewer, Epilepsy and Behavior

2013- Present Ad-hoc reviewer, Journal of Head Trauma Rehabilitation

2014- Present Ad-hoc reviewer, American Journal of Neuroradiology

2015- Present Review Editor, Frontiers in Neurology- Neurology Education

2015- Present Guest Reviewer, Continuum (American Academy of Neurology)

2007 Review committee- Congressionally-Directed Research Medical Programs’ TBI

Concept Awards Program (Neuro Panel A)

2007 Review committee- Congressionally-Directed Research Medical Programs’ TBI

Extramural Treatment Rehabilitation Panel

2008 Review committee- US Army Medical Research and Materiel Command

(USAMRMC) FY2008 Intramural War Supplemental Program

2009 Review committee- Health Research Council of New Zealand Trans-Tasman

Clinical Trials Collaboration, 2009

2009 Grant review committee- Colorado Injury Control Research Center

Seed Grant Program

2009 Review committee- US Army Medical Research and Materiel Command

(USAMRMC) FY2009 Intramural War Supplemental Program

2010 Reviewer, US Army Medical Research and Materiel Command

(USAMRMC) FY2010 Investigator-initiated Grant Program

2010 Review committee- Colorado Clinical and Translational Sciences Institute Co-

Pilot Grant Program

2011 Reviewer, US Army Medical Research and Materiel Command

(USAMRMC) FY2011 Investigator-initiated Grant Program

Invited Lectures and Presentations:

Local:

• Frey LC. Epilepsy and Behavior. Invited Speaker. Neurology Grand Rounds, UCD. December 2005.

• Frey LC. The Diagnostic Power of EEG. Invited Speaker. Neurology Grand Rounds, UCD. January 2007.

• Frey LC. Leukotrienes and Traumatic Brain Injury. Invited Speaker. Neurology Grand Rounds, UCD. August 2008.

• Damek D, Frey LC, Rollins Y, Strom L. Collaborative Peer Mentoring Groups: An alternative to traditional dyadic mentoring. CU Women Succeeding Symposium. UCD. March 2009.

• Frey LC. How Can We Measure Posttraumatic Epileptogenesis? Invited Speaker. Epilepsy Research Forum, UCD. March 2009.

• Frey LC. Traumatic Brain Injury and Posttraumatic Epileptogenesis. Invited Speaker. Graduate Neuroscience Program Seminar. April 2009.

• Frey LC. EEG Abnormalities in Adults. Invited Speaker. UCD/National Jewish Hospital Sleep Medicine Conference. July 2009.

• Frey LC. Neurological Emergencies: Status Epilepticus. Neurology Department Emergency Lecture Series. July 2009.

• Frey LC. Potential Biomarkers in Posttraumatic Epileptogenesis. Invited Speaker. Epilepsy Research Forum, UCD. November 2009.

• Frey LC. Quantitative MRI Endpoints Predict Seizure Susceptibility after Experimental Traumatic Brain Injury. Invited Speaker. Neurology Grand Rounds, UCD. August 2010.

• Frey LC. Curious about Neurofeedback? Invited Speaker. Neurology Grand Rounds, UCD. February 2012.

• Frey LC. Neurological Emergencies: Status Epilepticus. Neurology Department Emergency Lecture Series. July 2012.

• Frey LC. Epilepsy is a Whole Brain Disease. Invited Speaker. Behavioral Neurology and Neuropsychiatry Monthly Seminar, UCD. November 2012.

• Frey LC. EEG Abnormalities in Adults. Invited Speaker. UCD/National Jewish Hospital Sleep Medicine Conference. March 2013.

• Frey LC. Abnormal Adult EEG. Invited Speaker. UCD/National Jewish Hospital Sleep Medicine Conference. November 2013.

• Frey LC, Spitz MC, Strom LA. Treatment Options for Intractable Temporal Lobe Epilepsy: Part 2. Invited Speaker. Neurology Grand Rounds, UCD. August 2013.

• Frey LC. EEG Abnormalities in Adults. Invited Speaker. UCD/National Jewish Hospital Sleep Medicine Conference. January 2015.

• Frey LC and others. Demystifying Promotion and Tenure. Invited Panelist. UCD Junior Faculty Career Promotion Retreat. May 2015.

• Morris C, Garrett K, Frey LC. Peer to Peer (PTP) Support Network Training. Invited speaker. November 2015.

• Frey LC. Adverse clinical events and the second victim: What happens and strategies to make it better. Invited speaker. Academy of Medical Educators Faculty Development Seminar. December 2015.

• Frey LC. Adult EEG- Abnormalities. Invited Speaker. UCD/National Jewish Hospital Sleep Medicine Conference. January 2016.

• Frey LC. Peer-to-Peer Faculty Network. Invited Speaker. UCD New Faculty Career Development Workshop. March 2016.

• Simpson J, Drees C, Frey LC, Galperin D. Quality Case Reviews: Conflict resolution. Invited Panelist. Neurology Grand Rounds, UCD. January 2016.

• Frey L and Tollin D. How to Optimally Advance Towards Promotion and Tenure. Invited Speaker. UCD Junior Faculty Career Promotion Retreat. June 2016.

Regional:

• Frey LC. TBI and Epilepsy Across the Age Spectrum. Invited Keynote Address. Brain Injury Association of Colorado, 22nd Annual Conference, Vail, Colorado. October 2004.

• Frey LC. An Update on Epilepsy and Behavior: A Rapidly Changing Landscape. Invited Speaker. Third Biennial Rocky Mountain Epilepsy Conference, Breckenridge, Colorado. January 2006.

• Frey LC. Seizure Recognition During Sleep Analysis. Invited Speaker. Second Annual Rocky Mountain Allied Sleep Conference, Denver, Colorado. March 2008.

• Frey LC. Neurological Issues in Adults. Invited Panelist. Rocky Mountain Regional TSC Conference. April 2009.

• Raible D, Frey L, Brooks-Kayal A. JaK/STAT Inhibition to Prevent Post-traumatic Epileptogenesis. Rocky Mountain Regional Neurosciences Group. April 2011.

• Frey LC, Murphy RC, Heidenreich K. Targeting the 5-Lipoxygenase (5-LO) Pathway in TBI. Brain Injury Professionals Partnership 4th Annual Translational Neuroscience Conference. March 2011.

• Frey LC. Epilepsy and Seizures after Traumatic Brain Injury. Invited Speaker. Brain Injury Association of Colorado, 29th Annual Conference, Englewood, Colorado. October 2011.

• Frey LC. Quantitative EEG. Invited Speaker. Colorado Society of Electrodiagnostic Technologists. Aurora, Colorado. April 2012.

• Frey LC. Beyond Medications. Invited Speaker. Epilepsy Foundation of Colorado. November 2014.

National/ International:

• Frey LC, Lepkin A, Hasebroock K, Serkova N. Blood-brain barrier disruption on T1-weighted MRI is a biomarker for seizure susceptibility after experimental traumatic brain injury in the rat. Platform A-05. Annual Meeting of the American Epilepsy Society. December 2010.

• Frey LC. Impact of sensorimotor rhythm (SMR) neurofeedback on quality of life in patients with medically-refractory seizures. Oral platform presentation. Annual Meeting of the International Society for Neurofeedback Research. October 2015.

• Frey LC. Epilepsy, seizures and neurofeedback. Invited workshop. Annual Meeting of the International Society for Neurofeedback Research. October 2015.

• Frey LC. Small group discussion: Epilepsy and neurofeedback. Invited facilitator. Annual Meeting of the International Society for Neurofeedback Research. October 2015.

• Frey LC. Epilepsy, seizures and neurofeedback in 2016. Invited workshop. Annual Meeting of the International Society for Neurofeedback Research. September 2016.

• Frey LC. Neurofeedback for epilepsy: development of a multicenter outcomes database. Invited speaker. Annual Meeting of the International Society for Neurofeedback Research. September 2016.

• Frey LC. State of the Field - Research and Trends in Neurofeedback and Neuromodulation: Clinical work and Applications. Invited Panelist. Annual Meeting of the International Society for Neurofeedback Research. September 2016.

Teaching Record:

Presentations to Medical Students:

2005, 2007, 2011

2014, 2015 The Neurological Exam: Foundations of Doctoring Course, UCD

2.2014 NRSC 7614: Biological Basis of Psychiatric and Neurological Disorders: Epilepsy, UCD

2.2016 NRSC 7614: Seizures and epilepsy: What is good to know?, UCD

4.2016 ICC 7001: Medical Students and Medical Errors, UCD

5.2016 ICC 7003: Error Disclosure, UCD

Presentations to House Officers:

2002- 2003 Epilepsy Research Seminar Series, Columbia Comprehensive Epilepsy Center

2004- Present Core Curriculum Series, Neurology Residency Training Program, UCD

2007, 2009, 2013 Journal Club faculty presenter, Neurology Residency Training Program, UCD

2008, 2010, 2013 Special EEG teaching series for elective rotation students and others

2010 Special Evoked Potential teaching series for elective rotation student and others

2013- Present Core Curriculum Series, Combined Adult/Pediatric Epilepsy Fellowship Didactics, UCD

Ward/Clinic Attending Duties:

2004- Present Supervision and bedside teaching of neurology residents in Epilepsy Monitoring

Unit.

2004- Present Supervision and teaching of epilepsy fellow in Epilepsy Monitoring Unit and

outpatient EEG laboratory.

2004- 2011 Supervision and bedside teaching of neurology residents on General Neurology

Inpatient/Consult Service.

2010- 2012 Clinical preceptor, MSTP Foundations of Doctoring course (Ajay Thomas)

2011- 2012 Clinical mentor, CCTSI TL-1 Clinical Translational Science PhD Program (Daniel Raible)

Other Specific Accomplishments:

Neurology Department:

2005- 2011 Creation and periodic revision of Epilepsy Syllabus for neurology residents

2005- 2008 Faculty resident mentor- Dr. Michelle Moon

2006 Initial creation and implementation of Epilepsy/EEG Didactic Curriculum for neurology

residents

2007- 2014 Creation and administration of the Epilepsy/Clinical Neurophysiology elective

rotation for neurology residents

2009- 2012 Faculty resident mentor- Dr. Emily Lampe

2011- 2012 Faculty research mentor- Dr. Emily Lampe

2011- 2012 Faculty research mentor- Dr. Danielle McDermott

2011- 2012 Faculty research mentor- Dr. Kim Horiuchi

2011- 2013 Department of Neurology- Epilepsy Didactic Block Director

2012- 2015 Faculty resident mentor- Dr. Laura Friedlander

2013 Faculty judge, Neurology resident research presentations

2014- Present Director of Department of Neurology Journal Club

University of Colorado Anschutz Medical Campus:

2008 Faculty mentor, Metro State Internship (Cherri Unkart)

2009- 2012 Thesis committee member: Kristen Ryan, PhD candidate, Department of

Toxicology, UCD

2009- 2010 Faculty mentor, LAB COATS program (Alyssa Schickedanz)

2010 Faculty judge, Mentored Student Activity presentations, UCSOM

2010- 2014 Thesis committee member: Daniel Raible, PhD candidate, Department of

Neuroscience, UCD

2011- 2012 Clinical mentor, Daniel Raible, TL-1 Training Grant

2011 CREATE Health Scholars Program mentor

Other Teaching Accomplishments:

2015 Creation of CE activity with the Biofeedback Certification International Alliance.

2016 Creation of CME activity (EEG Atlas) with the American Epilepsy Society.

Grant Support:

• Colorado Injury Control Research Center/ Centers for Disease Control 7/1/05 – 6/31/06 COMPLETED

Lauren C. Frey, MD (PI) Total Award: $14,994

“EEG and Epileptogenesis after kainite-induced status epilepticus”

Investigates the power of longitudinal changes in EEG spike morphology to predict the occurrence of chronic seizures after brain injury from kainate-induced status epilepticus.

Role: Principal Investigator

• Colorado Injury Control Research Center/ Centers for Disease Control 8/1/07-7/31/10 COMPLETED

Lauren C. Frey, MD (PI) Total Award: $270,000

“EEG and Epileptogenesis after experimental traumatic brain injury”

Investigates the power of EEG and quantitative MRI endpoints to predict seizure susceptibility after severe experimental traumatic brain injury.

Role: Principal Investigator

• Colorado TBI Trust Fund 7/1/08- 6/30/10 COMPLETED

Kim Heidenreich, PhD (PI) Total Award: $275,000

“The Role of Leukotrienes in Traumatic Brain Injury”

Investigates the changes in cys-leukotriene levels in brain tissue and the effect of blocking leukotriene synthesis on anatomical and functional outcomes after experimental traumatic brain injury.

Role: Co- Principal Investigator

• Colorado Clinical and Translational Sciences Institute 4/1/10-9/30/11COMPLETED

Lauren C. Frey, MD (PI) Total Award: $20,000

“Cys-leukotrienes and oxidative stress after experimental traumatic brain injury”

Investigates the effect and clinical significance of injury-related cys-leukotriene production on local redox balance after traumatic brain injury.

Role: Principal Investigator

• Colorado Clinical and Translational Sciences Institute

TL-1 Clinical Translational Science Training Award 7/1/11- 6/30/12 COMPLETED

Daniel Raible (PI) Total Award: $27,725

“JaK/STAT inhibition and epilepsy after TBI”

Investigates the role of the JaK/STAT signaling cascade in regulation of brain inhibition after TBI, and on the potential utility of modulating this pathway acutely or chronically after TBI for preventing epilepsy development or inhibiting its progression.

Role: Collaborator, Clinical Mentor

• University of Colorado Hospital 9/1/11- 8/30/13 COMPLETED

University of Colorado Hospital Small Grants Program Total Award: $25,000

“Lumbar Puncture Simulation Training for University of Colorado Hospital Residents in Post-Graduate Year 1 (PGY-1) Training”

Victoria Pelak, MD, and Lauren Frey, MD (Co-PIs)

Investigates the efficacy of a virtual-reality based lumbar puncture simulator (developed for this study) in improving hospital-based lumbar puncture success rates among PGY-1 residents at a large, academic training hospital.

Role: Co-PI

• Department of Defense 3/1/11- 2/28/14 COMPLETED

U.S. Army Medical Research and Materiel Command Total Award: $1,073,010

Congressionally Directed Medical Research Programs

Investigator-Initiated Research Award

Amy Brooks-Kayal, MD (PI)

“JaK/STAT inhibition to prevent posttraumatic epileptogenesis”

Investigates the role of the JaK/STAT signaling cascade in regulation of brain inhibition after TBI, and on the potential utility of modulating this pathway acutely or chronically after TBI for preventing epilepsy development or inhibiting its progression.

Role: Collaborator

• American Academy of Neurology 7/1/15- 6/3/16 COMPLETED

Education Research Grant Program Total Award: $10,000

Augusto Miravalle, MD (PI)

“Enhancing professionalism among neurology residents by developing a leadership curriculum”

Investigates the impact of a leadership curriculum on resident communication and interpersonal skills.

Role: Co-Investigator

Bibliography:

Peer-reviewed Articles:

2002 Frey LC, Sung GY, Tanabe J. Early false-negative diffusion-weighted imaging in brainstem infarction. Journal of

stroke and cerebrovascular diseases: the official journal of National Stroke Association. 2002;11(1):51-3. Epub

2007/10/02.

2005 Frey LC, Ringel SP, Filley CM. The natural history of cognitive dysfunction in late-onset GM2 gangliosidosis.

Archives of neurology. 2005;62(6):989-94. Epub 2005/06/16.

2009 Frey LC, Hellier J, Unkart C, Lepkin A, Howard A, Hasebroock K, et al. A novel apparatus for lateral fluid

percussion injury in the rat. Journal of neuroscience methods. 2009;177(2):267-72. Epub 2008/11/22.

2009 Frey LC, Strom LA, Shrestha A, Spitz MC. End-of-dose emergent psychopathology in ambulatory patients with

epilepsy on stable-dose lamotrigine monotherapy: a case series of six patients. Epilepsy & behavior: E&B.

2009;15(4):521-3. Epub 2009/08/01.

2009 Farias S, Frey LC, Murphy RC, Heidenreich KA. Injury-related production of cysteinyl leukotrienes contributes to

brain damage following experimental traumatic brain injury. Journal of neurotrauma. 2009;26(11):1977-86.

Epub 2009/11/06.

2011 Hankin JA, Farias SE, Barkley RM, Heidenreich K, Frey LC, Hamazaki K, et al. MALDI mass spectrometric imaging

of lipids in rat brain injury models. Journal of the American Society for Mass Spectrometry. 2011;22(6):1014-21. Epub 2011/09/29.

2012 Rodgers KA, Deming YK, McCallum DL, Frey LC, Johnson KW, Watkins LR, Barth DS. Acute neuroimmune

modulation prevents the development of anxiety-like behavior in and animal model of traumatic brain injury.

Journal of Neurotrauma 2012;29:1886-1897.

2012 Raible DJ, Frey LC, Cruz Del Angel Y, Russek SJ, and Brooks-Kayal AR (2012) GABAA Receptor Regulation after

Experimental Traumatic Brain Injury. Journal of Neurotrauma 2012;29:2548-2554.

2014 Frey L, Lepkin A, Schickedanz A, Hasebroock K, Brown MS, Serkova N. ADC mapping and T1-weighted signal

changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury. Neurological Research 2014;36:26-37.

2014 Lampe E, Forster J, Herbst E, Spitz M, Frey L. Pre-admission Clinical Factors Affect Length of Stay in the Epilepsy

Monitoring Unit. The Neurodiagnostic Journal 2014;54:138-147.

2014 Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzjia P, Murphy RC, Farias SE, Dell-Acqua ML, Frey LC, Serkova N,

Heidenreich KA. Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and

associated cognitive deficits. Experimental Neurology 2014;256:7-16.

2014 Raible DJ, Frey LC, Brooks-Kayal A. Effects of JAK2-STAT3 signaling after cerebral insults. JAK-STAT

2014;3:e29510.

2015 Frey LC and Koberda JL. LORETA Z-score Neurofeedback in Patients with Medically Refractory Epilepsy. Neurol

Neurobiol 2015, Volume1.1:

2015 Raible DJ, Frey LC, Cruz Del Angel Y, Carlsen J, Hund D, Russek SJ, Smith BN. JAK/STAT pathway regulation of

GABAA receptor expression after differing severities of experimental TBI. Experimental Neurology

2015;271:445-456.

2016 Frey L. Impact of sensorimotor rhythm neurofeedback on quality of life in patients with medically-refractory

seizures: A pilot study. NeuroRegulation 2016;3:3-6.

2016 Drees C, Makic MB, Case K, Mancuso MP, Hill A, Walczak P, Limon S, Biesecker K, Frey L. Electrode-related skin

irritation during video-EEG monitoring. The Neurodiagnostic Journal 56 (3): 139-150, 2016.

Book Chapters, Invited Articles and Reviews:

2001 Arciniegas DB, Topkoff JL, Held K and Frey L. Psychosis due to neurologic conditions. Current Treatment Options

in Neurology 2001;4:347-366.

2003 Frey LC. Epidemiology of posttraumatic epilepsy: A critical review. Epilepsia 2003;44 Suppl 10:11-17.

2003 Frey L and Hauser WA. Epidemiology of neural tube defects. Epilepsia 2003;44 Suppl 3:4-13.

2005 Amatniek JC, Frey LC and Hauser WA. Gender differences in disease of the nervous system. In: Kaplan PW, Ed.

Neurologic Disease in Women, 2nd Ed. Demos Medical Publishing. New York, New York, 2005.

2009 Amatniek JC, Sorra K, Frey LC, Hauser WA. Gender differences in neurological disorders. In: Legato MJ, Ed.

Principles of Gender-Specific Medicine, 2nd Ed. Elsevier. San Diego, California, 2009.

2010 Strom LA, Koh S, Frey L. New antiepileptic drugs: Lacosamide, rufinamide and vigabatrin. Current Treatment

Options in Neurology 2010;12:287-299.

2013 Frey LC, Spitz MC. Physiologic Basis of EEG Generation of Electrical Activity of the Cerebral Cortex. In: Arciniegas

D, Anderson A, Filley C, Eds. Behavioral Neurology and Neuropsychiatry. 2013.

2013 Frey, LC. Clinical Diagnosis and Treatment of Posttraumatic Epilepsy. In: Arciniegas D, Jaffee M, Vanderploeg R,

Zasler N, Eds. Clinical Manual for the Management of Adults with Traumatic Brain Injury. 2013.

2014 Frey, LC, Hamilton B. Seizures. In: Fillipi M, Simon J, Eds. Imaging Acute Neurological Disease: A Symptom-based

Approach. Cambridge University Press. 2014.

2016 St. Louis, EK, Frey, LC (Eds.). Electroencephalography (EEG): An Introductory Text and Atlas of Normal and

Abnormal Findings in Adults, Children, and Infants. Chicago, IL: American Epilepsy Society; 2016.

.

Scientific Abstracts (Competitive):

2000 Frey L and Spitz M. Clinical recovery patterns in prolonged postictal aphasia. Epilepsia 2000;41 Suppl 7:104.

2002 Frey LC, Filley CM and Ringel SP. Cognitive dysfunction in Adult GM2 Gangliosidosis. American Academy of

Neurology Annual Meeting. April 2002.

2002 Frey LC and Karceski SC. A North American kindred with Familial Adult Myoclonic Epilepsy. Epilepsia 2002;43

Suppl 7:152.

2005 Spitz MC, Frey LC, Strom LA, Shrestha A, and Patz MD. Risk factors influencing the development and prognosis

of mania following anterior temporal lobectomy. Epilepsia 2005;46 Suppl 8:246.

2006 Frey LC, Strom LA, Shrestha A, Spitz MC. Withdrawal symptoms associated with lamotrigine. Abst 2.114.

American Epilepsy Society Annual Meeting. December 2006.

2006 Shrestha A, Frey L, Maa E, Strom L, Spitz M. Lamotrigine and late-onset rash. Abst 2.159. American Epilepsy

Society Annual Meeting. December 2006.

2008 White A, Shmueli D, Frey L, Waldbaum S, Patel M. Development of a cost-effective system with high-frequency

response to monitor video-EEG in a rat model of temporal lobe epilepsy. Abst 3.09. American Epilepsy Society

Annual Meeting. December 2008.

2009 Frey LC, Liang L, Lepkin A, Unkart C, Patel M. Pharmacological blockade of cys-leukotriene biosynthesis

ameliorates post-injury oxidative stress in a rat model of post-traumatic epilepsy. Abst. 3.111. American

Epilepsy Society Annual Meeting. December 2009.

2010 Strom LA, Frey LC, Spitz MC. Continuous EEG monitoring in a tertiary care facility. Abstract. American Clinical

Neurophysiology Society Annual Meeting. February 2010.

2010 Schickedanz A, Hasebroock K, Lepkin A, Serkova N, Frey LC. Assessment of a novel, non-invasive measure of

acute posttraumatic brain edema. Abstract. RaCAS Symposium. April 2010.

2010 Spitz, M, Moreland, S, Frey, L, O’Brien, C, Shrestha, A, Strom, L: Ablative temporal lobe epilepsy surgery should

be considered in patients with a pre-existing liver transplantation. Abstract 3.125. American Epilepsy Society

Annual Meeting. December 2010.

2010 Frey LC, Lepkin A, Hasebroock K, Serkova N. Blood-brain barrier disruption on T1-weighted MRI is a biomarker

for seizure susceptibility after experimental traumatic brain injury in the rat. Platform A-05. Annual Meeting of

the American Epilepsy Society. December 2010.

2011 Livsey C, Frey L, Spitz M. Is it peri-ictal cough or cough-related syncope? American Epilepsy Society Abstract

December 2011.

2012 Boychuk JA, Butler CR, Raible D, Frey L, Brooks-Kayal AR, Smith BN. Focal traumatic brain damage results in

localized GABA neuron loss and JAK/STAT activation early following injury. Abstract 2.007. American Epilepsy

Society Annual Meeting. December 2012.

2012 Lampe E, Herbst E, Frey L. Clinical factors affecting length of stay in the Epilepsy Monitoring Unit. Abstract

2.341. American Epilepsy Society Annual Meeting. December 2012.

2012 McDermott D, Strom L, Frey L. Presurgical evaluation of epilepsy surgery in adult patients with Tuberous

Sclerosis Complex. Abstract 3.289. American Epilepsy Society Annual Meeting. December 2012.

2012 Shrestha A, Larabee T, Frey L, Polovitz K, Campbell J. Deterioration in the EEG following rewarming in cardiac

arrest patients after mild therapeutic hypothermia. Abstract 3.078. American Epilepsy Society Annual Meeting.

December 2012.

2012 Spitz MC, Friedman M, Frey L. Drees C, Pearson S. Forensic implications of ictal or peri-ictal grabbing behaviors.

Abstract 3.093. American Epilepsy Society Annual Meeting. December 2012.

2013 Raible D, Boychuk J, Butler C, Cruz del Angel, Y, Russek S, Smith BN, Frey L, Brooks-Kayal A. Jak/STAT inhibition

to prevent post-traumatic epileptogenesis. Abstract 1.015. American Epilepsy Society Annual Meeting.

December 2013.

2013 Drees C, Makic M, Hill A, Limon S, Mancuso M, Walczak P, Biesecker K, Wikler K, Bravo K, Frey L. Incidence and

risk factors for electrode-related skin irritation during video-EEG monitoring. Abstract 2.002. American Epilepsy

Society Annual Meeting. December 2013.

2013 Spitz M, Drees C, Frey L, Fleming J, Bainbridge J, Pearson S, Shrestha A, Strom L. Pharmaco-adherence in

patients with epilepsy and neurologic tumors. Abstract 2.171. American Epilepsy Society Annual Meeting.

December 2013.

2013 Bainbridge J, Spitz M, Frey L, McDermott D, Drees C, O’Brien C, Strom L, Shrestha A, Pearson S. Retrospective

study of lacosamide in the elderly (>60). Abstract 2.172. American Epilepsy Society Annual Meeting. December

2013.

2013 McDermott D, Frey L, Faithe M, Bainbridge J, O’Brien C, Oh C, Pearson S, Shrestha A, Strom L, Spitz M, Drees C.

Improving time to treatment and resolution of status epilepticus. Abstract 3.153. American Epilepsy Society

Annual Meeting. December 2013.

2013 Frey L, Friedlander L, Strom L. Impact of Sensorimotor Rhythm (SMR) neurofeedback on quality of life in

patients with epilepsy: A case series. Abstract 3.222. American Epilepsy Society Annual Meeting. December

2013.

2014 Drees C, DeBello R, Frey L, Korb P, Shrestha A, Strom L, Spitz M, O’Brien C. Process improvement to reduce time

to epilepsy surgery. Abstract 2.053. American Epilepsy Society Annual Meeting. December 2014.

2014 Carlsen J, Raible D, Frey L, Brooks-Kayal A. Electrographic spiking and frequency power analysis in mouse CCI

models of TBI compared with memory and motor deficits. Abstract 3.031. American Epilepsy Society Annual

Meeting. December 2014.

2014 Spitz M, Moreland S, Horiuchi K, Lervik K, Korb P, Drees C, DeBello R, Strom L, Frey L, Shrestha A, O’Brien C.

Eyewitnesses of seizures are more accurate historians that the patients. Abstract 3.205. American Epilepsy

Society Annual Meeting. December 2014.

2014 Frey L, O’Brien C. LORETA z-score neurofeedback training in patients with drug-refractory epilepsy. Abstract

3.320. American Epilepsy Society Annual Meeting. December 2014.

2015 Miravalle A, Frey L, Simpson J, West M, Rich A. Leaders in Education, Administration and Research: Developing a

Leadership Curriculum in a Neurology Residency Program. Poster and abstract  presented at the Annual

American Academy of Neurology annual meeting, Washington, D.C. April 21, 2015.

2015 Miravalle A, Corboy J, Frey L, Jones W, Simpson J, Quan D, Rich A. Increasing Faculty Involvement in Educational Activities. Poster presentation at the Annual American Neurologic Association meeting, Chicago, IL September 28, 2015.

2015 Bainbridge J, Wong P-S, Spitz M, Frey L, Shrestha A, Strom L, Benbadis S, Sriven J, Chung SS. Retrospective study

of lacosamide in the elderly (>= 60 years of age). Abstract 3.073. American Epilepsy Society Annual Meeting.

December 2015.

2016 Miravalle A, Josefowitz R, Schreiner T, Ney D, Korb P, Anderson CA, Frey L, McNulty M, Aagaard E. Development

of validated neurology-specific rotational EPAs for GME. Poster presentation American Association of Medical

Colleges Annual Meeting. November 2016.

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