Mark N - Neuroscience



Curriculum Vitae

Mark N. Wu

August, 2014

DEMOGRAPHIC AND PERSONAL INFORMATION

Assistant Professor in Neurology, Medicine, Neuroscience, and Genetic Medicine

Johns Hopkins University, Rangos 289

855 N. Wolfe Street

Baltimore, MD 21205

410-502-7511 (office), 410-502-5459 (fax)

marknwu@jhmi.edu

EDUCATION AND TRAINING

1993 BA, Biology, cum laude Cornell University, Ithaca, NY

1999 PhD, Cell Biology Baylor College of Medicine, Houston, TX

2001 MD, with honor Baylor College of Medicine, Houston, TX

2001-2002 Intern, Internal Medicine Baylor College of Medicine, Houston, TX

2002-2005 Resident, Neurology University of California, Los Angeles, CA

2005-2007 Fellow, Sleep Medicine University of Pennsylvania, Philadelphia, PA

2005-2009 Postdoctoral Fellow, Neuroscience University of Pennsylvania, Philadelphia, PA

PROFESSIONAL EXPERIENCE

2007-2009 Instructor, Neurology, University of Pennsylvania, Philadelphia, PA

2009-present Assistant Professor, Department of Neurology, Johns Hopkins University

2009-present Assistant Professor, Department of Medicine, Johns Hopkins University

2010-present Assistant Professor, Department of Neuroscience, Johns Hopkins University

2012-present Assistant Professor, Institute of Genetic Medicine, Johns Hopkins University

RESEARCH ACTIVITIES

Publications

Original research

1. Wu, M.N., Littleton, J.T., Bhat, M.A., Prokop, A., and Bellen, H.J. (1998). ROP, the Drosophila Sec1 Homolog, Interacts with Syntaxin and Regulates Neurotransmitter Release in a Dosage Dependent Manner. EMBO J. 17, 127-139.

2. Wu, M.N., Fergestad, T., Lloyd, T.E., He, Y., Broadie, K., and Bellen, H.J. (1999). Syntaxin 1A Interacts with Multiple Exocytic Proteins to Regulate Neurotransmitter Release In Vivo. Neuron 23, 593-605.

3. Mao, Y., Nickitenko, A., Duan, X., Lloyd, T.E., Wu, M.N., Bellen H.J., and Quiocho, F.A. (1999). Crystal structure of the VHS and FYVE Tandem Domains of HRS, a Protein Involved in Membrane Trafficking and Signal Transduction. Cell 100, 447-456.

4. Fergestad, T*., Wu, M.N.* (co-first author), Schulze, K.L., Lloyd, T.E., Bellen, H.J., and Broadie, K. (2001). Targeted Mutations in the Syntaxin H3 Domain Specifically Disrupt SNARE Complex Function in Synaptic Transmission. J. Neurosci. 21, 9142-9150.

5. Wu, M.N., Schulze, K.L., Lloyd, T.E., and Bellen, H.J. (2001). The ROP-Syntaxin Interaction Inhibits Neurotransmitter Release. Eur. J. Cell Biol. 80, 196-199.

6. Lloyd, T.E., Atkinson, R., Wu, M.N., Zhou, Y., Pennetta, G., and Bellen H.J. (2002). HRS Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signalling in Drosophila. Cell 108, 261-269.

7. Kremen, S., Wu, M.N., and Ovbiagele, B. (2005). Hemopericardium following Intravenous Thrombolysis for Acute Ischemic Stroke. Cerebrovasc. Dis. 20, 478-479.

8. Fogel, B., Wu, M.N., Kremen, S., Murthy, K., Jackson, G., and Vanek, Z. (2006). Creutzfeldt-Jakob Disease Presenting with Alien Limb Sign. Movement Disorders 21, 1040-1042.

9. Wu, M.N., Koh, K., Yue, Z., Joiner, W.J., Sehgal, A.S. (2008). A Genetic Screen for Sleep and Circadian Mutants Reveals Mechanisms Underlying Sleep in Drosophila. Sleep 31, 465-472.

10. Koh, K*., Joiner, W.J.*, Wu, M.N.* (co-first author), Yue, Z., Smith, C., Sehgal, A.S. (2008). Identification of Sleepless, a Sleep Promoting Factor. Science 321, 372-376.

11. Wu, M.N.*(co-first author), Ho, K.*, Yue, Z., Koh, K., and Sehgal, A.S. (2009). The Effects of Caffeine on Sleep and Circadian Rhythms in Drosophila Require PKA Signalling, but not the Adenosine Receptor. J. Neurosci. 29, 11029-11037.

12. Zheng, X., Koh, K., Sowcik, M., Smith, C., Chen, D., Wu, M.N., and Sehgal, A.S. (2009). An Isoform-specific Mutant Reveals a Role of PDP1ε in the Circadian Oscillator. J. Neurosci. 29, 10920-10927.

13. Wu, M.N.* (co-first author), Joiner, W.J.*, Dean, T.*, Smith, C., Yue, Z., Hoshi, T., Sehgal, A.S., and Koh, K. (2010). Sleepless Regulates Shaker Expression, Localization, and Function. Nature Neurosci. 13, 69-75. (Reviewed by Faculty of 1000)

14. Liu, Q., Liu, S., Kodama, L., Driscoll, M., and Wu, M.N. (2012). Two Dopaminergic Neurons Signal to the Dorsal Fan-shaped Body to Promote Wakefulness in Drosophila. Curr. Biol. 22, 2114-2123. (Previewed in Curr Biol).

15. Spira, A.P., Gamaldo, A.A., An, Y., Wu, M.N., Simonsick, E.M., Bilgel, M., Zhou, Y., Wong, D.F., Ferrucci,

L., and Resnick, S.M. (2013). Self-Reported Sleep and Beta-Amyloid Deposition in Community-Dwelling Older Adults. JAMA Neurology 70, 1537-1543.

16. Liu, S.*, Lamaze, A., Liu, Q., Yang, Y., Fowler, M., Bharadwaj, R., Zhang, J., Bedont, J., Blackshaw, S., Lloyd, T.E., Montell, C., Sehgal, A., Koh, K.*, and Wu, M.N.* (2014). WIDE AWAKE Mediates the Circadian Timing of Sleep Onset. Neuron 82, 151-166.

17. Spira, A.P., Yager, C., Brandt, J., Smith, G.S., Zhou, Y., Mathur, A., Kumar, A., Brasic, J.R., Wong, D.F., and Wu, M.N. (2014). Objectively-Measured Sleep and β-amyloid Burden in Older Adults: A Pilot Study. Sage Open Med (in press)

18. Jepson, J.E.C., Sahidullah, M., Liu, D., le Marchand, S.J., Liu, S., Wu, M.N., Levitan, I.B., Dalva, M.B., and Koh, K. (2014). Regulation of Synaptic Development by the Drosophila PDZ Domain Protein Dyschronic. Development (in press).

Reviews and Book Chapters

1. Wu, M.N. and Bellen, H.J. (1997). Genetic Dissection of Synaptic Transmission in Drosophila. Curr. Opin. Neurobio. 7, 624-630.

2. Pennetta, G., Wu, M.N., and Bellen, H.J. (1999). Dissecting the Molecular Mechanisms of Neurotransmitter Release in Drosophila in Neurotransmitter Release, Bellen, H.J. (ed.). Oxford University Press.

3. Sehgal, A., Joiner, W., Crocker, A., Koh, K., Sathyanarayanan, S., Fang, Y., Wu, M.N., Williams, J.A., Zheng, X. (2007). Molecular Analysis of Sleep:Wake Cycles in Drosophila. Cold Spring Harb. Symp. Quant. Biol. 72, 557-564.

4. Raizen. D.R. and Wu, M.N. (2011). Genome-wide Analysis of Sleep Disorders. Chest 139, 446-452.

5. Wu, M.N. and Raizen, D.R. (2011). Notch Signaling: a Role in Sleep and Stress. Curr. Biol. 21, R397-R398.

6. Spira, A.P., Chen-Edinboro, L.P., Wu, M.N., and Yaffe, K. (2014). Impact of Sleep on the Risk of Cognitive Decline and Dementia. Curr. Opin. Psychiatry. (in press)

Research Funding

Active

Career Award for Medical Scientists 9/1/07-8/31/15

Burroughs-Wellcome Fund (no-cost extension)

“Identification of novel genes that regulate sleep in Drosophila”

Role: PI

1R01NS079584 8/1/12-7/31/17

NINDS

“Genetic Analysis of Sleep Regulation”

Role: PI

New Investigator Research Grant 10/1/13-9/30/15

Alzheimer’s Association

“Mechanisms Underlying Sleep-Dependent Modulation of Abeta”

Role: PI

Simons Foundation 9/1/14-8/31/15

Explorer Grant

“The Role of Glia in Fragile X Syndrome”

Role: PI

Synergy Award 8/1/14-7/31/15

Johns Hopkins Discovery Fund

“Sleep-Disordered Breathing and Beta-amyloid in Down Syndrome”

Role: PI

Pending

1R21NS088521 4/1/15-3/31/17

NINDS

“Developing Genetic Reagents for the Dissection of Dopaminergic Circuitry”

Role: co-PI

Scored 3rd percentile.

Completed

1F31MH011375 1/1/96-5/31/99

NIMH

“Mutational Analysis of Syntaxin 1A in vivo”

Role: PI

1K08NS059671 4/1/08-3/31/13

NINDS

“Genetic and phenotypic characterization of catnap, a novel short sleeping mutant”

Role: PI

Synaptic Plasticity and Cognitive Disorders Award 6/1/11-5/31/13

Brain Science Institute, Johns Hopkins University

“Sleep/Wake Disturbance and β-amyloid: Translational Research in Humans and Fruit flies”

Role: co-PI

EDUCATIONAL ACTIVITIES

Teaching

2009-present Lecture on “Genetics of Sleep Disorders” for Sleep Medicine Conference

2009-present Lecture on “Circadian Rhythm Disorders” for Sleep Medicine Conference

2009-present Teaching of medical students, residents, and fellows during weekly Sleep Medicine clinic

2011-present Johns Hopkins Hospital Noon Neurology Resident Lecture on “Parasomnias”

2012-present Lecture on “Circadian Rhythms and Sleep” for Neuroscience Graduate NeuroCogII Course

2013-present Lecture on “Sleep and Alzheimer’s Disease” for Neurology Resident Journal Club

Mentoring

2009-present Sha Liu, Ph.D., postdoctoral fellow, won 1st place poster award at Johns Hopkins Neuroscience Retreat (2012), presented talk at national Cold Spring Harbor Neurobiology of Drosophila Conference in Laurel Hollow, NY (2013), presented talk at regional Circadian Clocks meeting in Philadelphia, PA (2013), 1st author manuscript published at Neuron. Wrote successful Explorer grant from Simons Foundation.

2009-present Qili Liu, Ph.D., postdoctoral fellow, presented talk at regional Circadian Clocks meeting in Philadelphia, PA (2011), presented poster at national Drosophila Research Conference meeting in Chicago, IL (2012), presented poster at national Cold Spring Harbor Neurobiology of Drosophila Conference in in Laurel Hollow, NY (2013), 1st author manuscript published in Current Biology

2010-2012 Maria Rosario Driscoll, research technologist, co-author on a published manuscript, now medical student at University of Maryland

2010-2013 Lay Kodama, undergraduate research assistant, obtained a Woodrow Wilson Undergraduate Research Fellowship Award under my mentorship, co-author on a published manuscript, presented poster “Dissecting the Dopaminergic Circuitry Underlying Feeding Behavior in Drosophila” at JHU Undergraduate Neuroscience Research Day in 2012 and also at national Drosophila Research Conference in 2013, gave oral presentation on “Dopamine and Feeding in Drosophila” at Woodrow Wilson Conference, won prestigious Churchill Scholarship to do research fellowship at Cambridge University (UK), attending MD/PhD program at UCSF

2010-2012 James Ying, undergraduate research assistant, now medical student at University of Texas, Southwestern

2010-present Julia Zhang, undergraduate research assistant, applying to medical school, nominee for Barry Goldwater Scholarship, received a Provost Undergraduate Research Award (PURA) under my mentorship, co-author on a submitted manuscript, presented poster “Sleepless and the Search for a Mammalian Homolog” at the TriBeta Honor Society Poster Session. Presented poster “Interactions of WAKE and RDL in Drosophila” at PURA conference; this work was featured in the Johns Hopkins Gazette. Attending medical school at University of Hawaii.

2011-2013 Rohini Siva Srinivas, undergraduate research assistant, applying to medical school, obtained a Woodrow Wilson Undergraduate Research Fellowship Award under my mentorship

2012-present Jay Daniels, undergraduate research assistant, obtained a Woodrow Wilson Undergraduate Research Fellowship Award under my mentorship

2013-present Wakako, Horiuchi, undergraduate research assistant

2013-present Benjamin Bell, graduate student in the Human Genetics program, applied for NSF and DOD graduate research fellowships

2013-present Masashi Tabuchi, Ph.D., postdoctoral fellow, applied for Uehara postdoctoral fellowship, successfully obtained a Japan Society for the Promotion of Science fellowship award under my mentorship.

2014-present Ting Xue, graduate student, on a China Scholarship Council fellowship award under my supervision.

Thesis Committee Member

2012-present PhD degree in Neuroscience for Chun-Chieh Lin

2014-present PhD degree in Cellular and Molecular Physiology for Hao Jia

2014-present PhD degree in Neuroscience for Darya Task

Qualifying Exam Committee Member

2013 PhD degree in Neuroscience for Travis Faust

2014 PhD degree in Neuroscience for Aneesh Donde

Training Grant Participation

2010-present T32, Neuroscience Training Program, Johns Hopkins University

2013-present T32, Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders, Johns Hopkins University (along with Stanford University, and University of Michigan)

CLINICAL ACTIVITIES

Medical Licensure

2005-2009 Licensed Physician, State of Pennsylvania

2009-present Licensed Physician, State of Maryland

Board Certification

2006 Diplomate, Neurology, American Board of Psychiatry and Neurology

2007 Diplomate, Sleep Medicine, American Board of Psychiatry and Neurology

Clinical Service Activities

2009-present Sleep Medicine attending at Johns Hopkins Sleep Disorders Center (1/2 day per week)

2010-2012 Neurology consult attending at Johns Hopkins Bayview Center (2 weeks per year)

2013-present Neurology consult attending at Johns Hopkins Bayview Center (4 weeks per year)

SYSTEM INNOVATION AND QUALITY IMPROVEMENT ACTIVITIES

Not Applicable

ORGANIZATIONAL ACTIVITIES

Committees

2010-present Johns Hopkins Sleep Medicine Academic Training Committee

2011-present Johns Hopkins Neurology Residency Selection Committee

2012-2013 Brain Science Institute Faculty Search Committee

2014-present Johns Hopkins Postdoctoral Fellows Advisory Board

2014-present Sleep Research Society Training/Pipeline Workgroup

2014-present Johns Hopkins Neurology Residency Selection Committee, co-chair

Editorial Activities

Ad hoc reviewer: Current Biology, Journal of Cell Biology, PLos Biology, Journal of Neuroscience, Sleep, PLoS One, Nature Protocols, Bioessays, Neurobiology of Aging

Guest editor: Journal of Experimental Neurology, Special Issue “Drosophila Models of Neurological Disease”

Grants Review

Ad hoc reviewer: NIH NSD-C Study Section, Israel Science Foundation, Alzheimer’s Association, Wellcome Trust DBT India Alliance, Research Foundation Flanders, Czech Science Foundation

Professional Memberships

2004-present Member, American Academy of Neurology

2008-present Member, Sleep Research Society

2009-present Member, Society for Neuroscience

2012-present Member, American Neurological Association

RECOGNITION

Awards

1989 Dean’s Scholar, Cornell University, Ithaca, NY

1993-2001 Medical Scientist Training Program, Baylor College of Medicine, Houston, TX

1993 Presidential Scholarship, Baylor College of Medicine, Houston, TX

1995 John J. Trentin Award for Scholastic Excellence, Baylor College of Medicine, Houston, TX

1996-1999 National Research Service Award Predoctoral Fellowship, National Institutes of Health

1996-1999 Dean’s Award, Baylor College of Medicine, Houston, TX

2000 Outstanding Graduate Student Award, Department of Molecular and Cellular Biology,

Baylor College of Medicine, Houston, TX

2000 Sigma Xi Outstanding Dissertation Award, Sigma Xi National Research Honor Society

2000 Best Overall Student in Basic Sciences and Clinical Clerkships, MD/PhD Program,

Baylor College of Medicine, Houston, TX

2005 Augustus Rose Resident Teaching Award, Department of Neurology, University of

California, Los Angeles, CA

2007 Career Award for Medical Scientists, Burroughs-Wellcome Fund

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