Lippincott Williams & Wilkins



Supplemental Figure 1. Mean serum electrolytes during parenteral nutrition by age groupMean ± standard deviation is presented for the total full analysis set by treatment day for (a)?calcium, (b)?sodium, (c) potassium, and (d)?phosphate. Numbers of patients with data are shown above the x axis for each time point.157162532385000Supplemental Figure 2. Mean serum phosphate during parenteral nutrition by age groupMean ± standard deviation is presented for the full analysis set by treatment day for (a)?patients aged 0 month to 1 month, (b) patients aged >1 month to 12 months, and (c)?patients aged >12 months to 24 months. Numbers of patients with data are shown above the x axis for each time point.Supplemental Figure 3. Mean change from baseline in body weight Mean ± standard deviation change from baseline is presented for the full analysis set.Supplemental Table 1. Adverse events of metabolism and nutrition disordersMedDRA system organ classPreferred termAll patients (N=102)*n (%)Rate per treatment day?Metabolism and nutrition disorders20 (19.6)0.033Hypertriglyceridemia7 (6.9)0.008Hypermagnesemia4 (3.9)0.004Hyperkalemia3 (2.9)0.003Hypokalemia3 (2.9)0.003Hyponatremia3 (2.9)0.003Hypophosphatemia3 (2.9)0.003Hyperglycemia2 (2.0)0.002Hypercalcemia1 (1.0)0.001Hypernatremia1 (1.0)0.001Hypovolemia1 (1.0)0.001Metabolic acidosis1 (1.0)0.001Vitamin D deficiency1 (1.0)0.001* Full analysis set.? Rate is the number of events divided by total exposure time, normalized to 24 hours.Abbreviations: MedDRA = Medical Dictionary for Regulatory Activities. Supplemental Table 2. International guidelines for parenteral magnesium intake (mmol/kg/day) in infants and children2014 AAP (22)2015 ASPEN (21)2016 Nutrition in Pediatrics 5th Ed. (20)2018 ESPGHAN/ ESPEN/ESPR/CSPEN (3)Age categoryMagnesium*Age categoryMagnesium*Age categoryMagnesium*Age categoryMagnesium*Preterm0.18–0.3Preterm0.15–0.25Preterm0.25–0.4Preterm0.2–0.3Term newborn0.25–0.4Infants/toddlers0.125–0.5Infants/children0.15–0.25Infants0.25–0.40–6 months0.1–0.2Children0.125–0.51–2 years0.1–0.257–12 months0.15Adolescents4–16 mmol/dayAdolescents >50 kg5–15 mmol/day2–18 years0.1–0.251–18 years0.1Abbreviations: AAP = American Academy of Pediatrics; ASPEN = American Society for Parenteral and Enteral Nutrition; CSPEN = Chinese Society of Parenteral and Enteral Nutrition; ESPEN = European Society for Clinical Nutrition and Metabolism; ESPGHAN = European Society for Paediatric Gastroenterology, Hepatology and Nutrition; ESPR = European Society of Paediatric Research. * Recommended parenteral magnesium intake in mmol/kg/day unless otherwise specified. ................
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