Lesson Plan Wednesday February 25th, 2004



Lesson Plan Wednesday February 25th, 2004

TLW learn an overview of metabolism and the major pathways

Activity 1: Five students will arrange themselves in the starch to glucose pathway

Discuss that this is an example of a metabolic pathway – series of enzyme-catalyzed reactions

Each product can also be a substrate for another enzyme

Activity 2: add sucrose and sucrase

Have students work out that pathways can merge

Then can also branch if two enzymes can use the same substrate

Metabolism – sum of all enzyme-catalyzed reactions in body

Anabolism – reactions that build bigger molecules from smaller, use energy

Catabolism – reactions that break down big molecules into smaller ones to get energy

Show Sigma Chart of Metabolic Pathways

Ask students what they notice about the chart

Hopefully notice color coding – represents different pathways

Notice glucose/glycolysis in middle – central pathway, probably most ancient

All pathways eventually are interconnected – branch and merge/converge

Read off pathway titles, ask students to classify them as anabolic or catabolic

Have one “anabolic” and one “catabolic” student write them on board

Adjust list below to reflect chart

Anabolic Catabolic

Amino acid synthesis Glycolysis

Lipid synthesis Citric Acid cycle

Hormone synthesis Electron transport chain

Photosynthesis lipolysis

Gluconeogenesis amino acid degradation

Lesson Plan Thursday 25th, 2004

TLW will connect metabolic pathways and identify the connecting chemicals - the products of one pathway that are the substrates for the next

Activity: Give the students paper cutouts representing the major pathways and blanks to fill in the connecting chemicals

Show/hang the chart

Let students arrange pathways, using the chart for reference, ask them to fill in the connecting chemicals

Students should have trouble linking CAC and ETC, others

Point out that they are not linked by carbon-based chemicals (building blocks) but instead are linked by energy molecules

Lecture Presentation

ATP – adenosine triphosphate – show carton segueing into chemical structure on PPT

Vs. ADP

Identify adenine and ribose – have them write the chemical formula for ribose

Talk about high energy bond, how many calories are in the bond

NADH/NADPH – electron carriers

Oxidized – lost electrons, lost energy

Reduced – gained electrons, gained energy

On PPT

NAD+ is oxidized, so has __________ energy

NADH is reduced, so has __________ energy

NADP+ is __________, so has __________ energy

NADPH is __________, so has __________ energy

Activity 2: Finish connecting pathways using ATP and NADH

Ask – what happens if one pathway uses up all the ATP or NADH?

Others can’t work – all must be regulated/share

Why taking extra of one chemical doesn’t always help

Assign students to write down three non-plant supplements in health food section of store and come look them up to se which pathway they are supposed to be boosting

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