“DEVOLOPMENT OF AN OSMOTIC DRUG DELIVERY SYSTEM: …
It has an half-life of 6.5 hrs and 50 to 60 % of bioavailability under fasting condition. Metformin SR (slow release) or XR (extended release) was introduced in 2004, in 500 mg and 750 mg strengths, mainly to counteract the most common gastrointestinal side effects, as well as to increase patient compliance by reducing pill burden. ................
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