Cross Reactants /potential reactants and cross-reactants

Cross Reactants /potential reactants and cross-reactants

Cross reactivity of structrally similar substances can be a problem associated with immunoassay methods, which can result in false positive or negative results. Screening technologies are predominantly immonoassay techniques which have proven to be highly sensitive but are of limited specificity. Manufacturers will test for common substances that may interfere with results and list these on product package inserts. It is not possible however, to test for every compound. In addition, some compounds ingested in therapeutic doses may not cross-react, however when abused in "mega" doses may significantly influence urine immonoassay results.

Below are potential reactants and cross-reactants with most immunoassay methods. This list is to be used as a reference guide only and in no way is intended to be a comprehensive guide used for analysis.

List is not all inclusive. It is possible that other substances and/or factors not listed may interfere with the test and cause false positve results.

All positive results from an onsite drug testing product are presumptive and should always be screened at the laboratory for immnoassay results. An additional confirmatory method such as gas chromatography/mass spectrometry (GC/MS) is also recommended.

Compound Acetaminophen

Acetaminophen with Codeine (see also Paracetamol with codeine)

Acetophenetidin Acetylsalicyclic acid

Allobarbital Alphenol Alprazolam

Aluminum Chloride Hexahydrate Aluminum Hydroxide

Alverine Citrate Aminopyrine Amitripyline Ammonia/peacuanha

Compound (trade name) Aceta, Acephen, Apacet, Dapacen, Feverall, Tylenol, Excedrin (combination), Panadol, Tempra Tylenol 3, Tylenol with codeine

Phenacetin Aspirin, Anadin, Anasin, Bufferin, Caprin, Disprin, Ecotrin, Empirin, Excedrin (combination) No known trade names No known trade names Xanax

Drichlor, Anhydrol Forte Alu-Cap, Alisone, Gastrocote, Kolanticon, Maalox, TC, Mucogel, Pyrogastrone, Topal Spasmonal, Spasmonal Fibre

Elavil, Lentizol, Tryptizol, Triptafen, Triptafen-M Ipecac

Results/Cross Reactants Non-reactive

Positive for Opiates (OPI, MOR/MOP) Potential cross reactants; Dihdrocodeine Non-reactive Non-reactive

Positive for Barbiturates (BAR) Positive for Barbiturates (BAR) Positive for Benzodiazepines (BZO) Potential cross reactants; Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive

Non-reactive Non-reactive Positive for Tricyclic Antidepressants (TCA) Non-reactive

Amobarbital Amoxicillin or Amoxycillin

Amphetamine/Methamphetamine

Ampicillin Antazoline Sulphate Aprobarbital Aspirin

Atenolol

Atorvastatin Azlocillin Barbital Beclometasone

Bendrofluazide

Benzalknomium Benzydamine HCl Benzidiazepines

Benzylpenicillin Bromazepam

Bromopheniramine Buprenorphine Buproprion Butabarbital Butalbital Canestan Carbamazepine Cephalexin Chloral Hydrate Chlordiazepoxide

Amytal, Tuinal Amoxil, Amoram, Augmentin, Heliclear AMP; Adderall, Dexedrine, Benzedrine, M/AMP; Desoxyn, Didrex Eldepryl

Penbritin, Polycillin, Principen Ortrivine-Anistin

Bayer Aspirin, Excedrin, ASA, Angettes, Asasantin, Caprin Beta-adlat, Co-tenidone, Kalten, Tenben, Tenif, Tenoret50, Tenorectic, Tenormin Lipitor Securopen

AeroBec, AeroBec Forte, Asmabec, Beclazone, Becloforte, Becodisks, Beconase, Becotide, Fillair, Nasobec, Qvar, Ventide, Zonivent Aprinox, Cogaretic, Indertic, Inderex, Neo-Naclax, Neo-NaclaxK, Pretim, Tenben Bradosol Difflam See individual Benzodiazepines listed Crystapen Lexotan

Dimetapp, Dimotapp, Dimotane Subutex, Temgesic Wellbutrin, Zyban Butisol, Soneryl Fioricet, Fiorinal Canestan ear/skin/vaginitis/HC Tegretol, Teril, Timonil Ceproex, Keflex Welldorm Librium

Positive for Barbiturates (BAR) Non-reactive

Positive for Amphetamines/Methamphetamines Potential cross reactants; Epherdrine, Pseudoephedrine, Phenylpropanolamine, Phentermine, Phenmetrazine, Ranitidine Non-reactive Non-reactive Positive for Barbiturates (BAR) Non-reactive

Non-reactive

Non-reactive Non-reactive Positive for Barbiturates (BAR) Non-reactive

Non-reactive

Non-reactive Non-reactive Potential cross reactants; Oxaprozin (Daypro), Sertraline Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants; Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Non-reactive Positive for Barbiturates (BAR) Positive for Barbiturates (BAR) Non-reactive Non-reactive Non-reactive Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants; Oxaprozin (Daypro), Sertraline

Chlorhexidine Gluconate

Chlorpheniramine Maleate Chlorpromazine Cimetidine Clobazam

Clonazepam

Clorazepate

Citalopram Co-Amoxiclav Codeine Phosphate

Co-Fluampicil Co-Phenotrope (atropine/diphenoxylate) Delorazepam

Dexamethasone

Dextroamphetamine Dextropropoxyphene Diazepam

Diclofenac Sodium Diclomine Dihydrocodeine Dimethicone Diphenhydramine Dipenoxylate with Atropine Dothiepin Doxycycline

Bactgras, Cordsodyl, Chlorohex, CX Powder, Dermol, Hibicet, Hibiscrub, Hibisol, Hibitane, Instillagel, Naseptin, Nystaform, Serotulle, Steripod, Tisept, Unisept, Uriflex, Uro-Trainer Galpseud, Haymine, Piriton Largactil Dyspamet, Tagamet, Zita Frisium

Clonopin, Klonopin, Rivotril

Tranxene

Cipramil Augmentin, Augmentin Duo Codafen, Continus, Codeine Linctus, Pediatric BP, Galcodine, Kapake, Migraleve, Solpadol, Tylex Magnapen Lomotil, Trepergen

Non-reactive

Non-reactive Non-reactive Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants: Dihydrocodeine Non-reactive Non-reactive

Briantum

Decadron, Dexa-Rhinaspray Suo, Maxidex, Maxidrol, Minims, Otomize, Sofradex Adderall, Adderall XR, Dexedrine Darvon, Darvocet, Co-proximal Diazemuls, Stesolid, Valclair, Valium

Dicloflex, Diclomax, Motifene, Volraman, Volsaid, Voltarol Kolanticon, Merbentyl DHC Continus, Paramol, Remedeine, Remedeine Forte Asilone, Fancorsil Benadryl, Medinex, Nytol, Panadol Night Lomotil Prothiaden Vibramycin, Vibramycin-D

Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive

Positive for Amphetamine (AMP) Positive for Propoxyphene (PPX) Positive for Benzidiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive

Non-reactive Potential Positive for Opiates (OPI, MOR/MOP) Non-reactive Non-reactive

Non-reactive Non-reactive Non-reactive

Doxepin Efavirenz Erythromycin

Estazolam

Ethambutol Ethylmorphine

Flucloxacillin Flunitrazepam

Fluoxetine Flupentixol Fusidic Acid (Sodium Fusidate) Gentamicin Sulphate Hydrocodone

Hydrocortisone Hydrocortisone-17 butyrate Hydromorphone

Hydroxychlorquine Hydroxyzine Hydrochloride Hyoscine butylbromide Ibuprofen Indomethacin Interferon Alfa Isoniazide Isosorbide Dinitrate Koalin and Morphine Mixture

Ketoprofen Lactulose

Sinequan, Xepin Sustiva Arpimycin, Benzymycin, Erycane, Erymax, Erythrocin, Erythroped, Ilosone, Isotrexin, Lactobinate, Stiemycin, Tiloryth, Zineryl ProSom

Myambutol

Co-fluampicil, Floxapen, Magnapen Rohypnol

Prozac, Sarafem Depixol, Fluanxol Fucithalmic, Fucibet, Fucidin Cidomycin, Genticin, Gentisone Lorcet, Loratab, Vicodin

Locoid, Locoid C Dilaudid, Hydrostat

Plaquenil Atarax, Ucerax Busocopan, Scopoderm Flexin continus, Indocid, Indomod Roferon-A, Intron A, Viraferon, Wellferon INH Diocalm, Entersan, Opazimes

Orudis, Oruvail, Powergel Lactugel, Duphalec

Positive for Tricyclic Antidepressants (TCA) Potential Positive for Marijuana (THC) Non-reactive

Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants: Dihydrocodeine Non-reactive

Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Non-reactive Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants: Dihydrocodeine Non-reactive Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants: Dihydrocodeine Non-reactive Non-reactive Non-reactive Non-reactive Non-reactive Non-reactive

Non-reactive Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants; Dihydrocodeine Non-reactive Non-reactive

Lamotrigine Lansoprazole Lisinopril HCl Lofepramine Lofexidine Loperamide HCl Loratadine Lorazepam

Lormetazepam

Magnesium Alginate Mannitol Medazepam

Mefenamic Acid Meperidine Metoclopramide Methadone Hydrochloride

d-Methamphetamine HCl

I-Methamphetamine HCL

Methylenedioxyamphetamine (MDA)

Metronidazole

Lamitcal Heliclear, Zoton Carace, Zestril, Zestoretic Gamanil, Lomont Britoflex Imodium, Loperagen, Norimide Claritin Ativan

Noctamide

Gaviscon Gaviscon Anxitol, Lerisum, Medacepan, Nobritol, Nobrium Ponstan, Ponstel Demerol, Pethidine Reglan Dolophine, Methadose, Physetone Desoxyn, Methedrine, Methamprex

Vick's Inhaler

Eve (slang), Love Drug (slang)

Anabact, Elyzol, Flagyl, Metrogel, Metrolyl, Metrotop, Neuratop, Noritate, Rozex, Zidoval, Zymoet

Potential Positive for PCP Non-reactive Non-reactive Positive for Tricyclic Antidepressants (TCA) Non-reactive Non-reactive Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Non-reactive Positive for Methadone (MTD) Potential cross reactants: Doxylamine Postive for Methamphetamine (mAMP) Potential cross reactants: Epherdrine, Pseudoephedrine, Phenylpropanolamine, Phentermine, Phenmetrazine, Ranitidine Positive for Methamphetamine (mAMP) Potential cross reactants: Epherdrine, Pseudoephedrine, Phenylpropanolamine, Phentermine, Phenmetrazine, Ranitidine Positive for Amphetamine (AMP) Potential cross reactants: Epherdrine, Pseudoephedrine, Phenylpropanolamine, Phentermine, Phenmetrazine, Ranitidine Non-reactive

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