Cross Reactants /potential reactants and cross-reactants
Cross Reactants /potential reactants and cross-reactants
Cross reactivity of structrally similar substances can be a problem associated with immunoassay methods, which can result in false positive or negative results. Screening technologies are predominantly immonoassay techniques which have proven to be highly sensitive but are of limited specificity. Manufacturers will test for common substances that may interfere with results and list these on product package inserts. It is not possible however, to test for every compound. In addition, some compounds ingested in therapeutic doses may not cross-react, however when abused in "mega" doses may significantly influence urine immonoassay results.
Below are potential reactants and cross-reactants with most immunoassay methods. This list is to be used as a reference guide only and in no way is intended to be a comprehensive guide used for analysis.
List is not all inclusive. It is possible that other substances and/or factors not listed may interfere with the test and cause false positve results.
All positive results from an onsite drug testing product are presumptive and should always be screened at the laboratory for immnoassay results. An additional confirmatory method such as gas chromatography/mass spectrometry (GC/MS) is also recommended.
Compound Acetaminophen
Acetaminophen with Codeine (see also Paracetamol with codeine)
Acetophenetidin Acetylsalicyclic acid
Allobarbital Alphenol Alprazolam
Aluminum Chloride Hexahydrate Aluminum Hydroxide
Alverine Citrate Aminopyrine Amitripyline Ammonia/peacuanha
Compound (trade name) Aceta, Acephen, Apacet, Dapacen, Feverall, Tylenol, Excedrin (combination), Panadol, Tempra Tylenol 3, Tylenol with codeine
Phenacetin Aspirin, Anadin, Anasin, Bufferin, Caprin, Disprin, Ecotrin, Empirin, Excedrin (combination) No known trade names No known trade names Xanax
Drichlor, Anhydrol Forte Alu-Cap, Alisone, Gastrocote, Kolanticon, Maalox, TC, Mucogel, Pyrogastrone, Topal Spasmonal, Spasmonal Fibre
Elavil, Lentizol, Tryptizol, Triptafen, Triptafen-M Ipecac
Results/Cross Reactants Non-reactive
Positive for Opiates (OPI, MOR/MOP) Potential cross reactants; Dihdrocodeine Non-reactive Non-reactive
Positive for Barbiturates (BAR) Positive for Barbiturates (BAR) Positive for Benzodiazepines (BZO) Potential cross reactants; Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive
Non-reactive Non-reactive Positive for Tricyclic Antidepressants (TCA) Non-reactive
Amobarbital Amoxicillin or Amoxycillin
Amphetamine/Methamphetamine
Ampicillin Antazoline Sulphate Aprobarbital Aspirin
Atenolol
Atorvastatin Azlocillin Barbital Beclometasone
Bendrofluazide
Benzalknomium Benzydamine HCl Benzidiazepines
Benzylpenicillin Bromazepam
Bromopheniramine Buprenorphine Buproprion Butabarbital Butalbital Canestan Carbamazepine Cephalexin Chloral Hydrate Chlordiazepoxide
Amytal, Tuinal Amoxil, Amoram, Augmentin, Heliclear AMP; Adderall, Dexedrine, Benzedrine, M/AMP; Desoxyn, Didrex Eldepryl
Penbritin, Polycillin, Principen Ortrivine-Anistin
Bayer Aspirin, Excedrin, ASA, Angettes, Asasantin, Caprin Beta-adlat, Co-tenidone, Kalten, Tenben, Tenif, Tenoret50, Tenorectic, Tenormin Lipitor Securopen
AeroBec, AeroBec Forte, Asmabec, Beclazone, Becloforte, Becodisks, Beconase, Becotide, Fillair, Nasobec, Qvar, Ventide, Zonivent Aprinox, Cogaretic, Indertic, Inderex, Neo-Naclax, Neo-NaclaxK, Pretim, Tenben Bradosol Difflam See individual Benzodiazepines listed Crystapen Lexotan
Dimetapp, Dimotapp, Dimotane Subutex, Temgesic Wellbutrin, Zyban Butisol, Soneryl Fioricet, Fiorinal Canestan ear/skin/vaginitis/HC Tegretol, Teril, Timonil Ceproex, Keflex Welldorm Librium
Positive for Barbiturates (BAR) Non-reactive
Positive for Amphetamines/Methamphetamines Potential cross reactants; Epherdrine, Pseudoephedrine, Phenylpropanolamine, Phentermine, Phenmetrazine, Ranitidine Non-reactive Non-reactive Positive for Barbiturates (BAR) Non-reactive
Non-reactive
Non-reactive Non-reactive Positive for Barbiturates (BAR) Non-reactive
Non-reactive
Non-reactive Non-reactive Potential cross reactants; Oxaprozin (Daypro), Sertraline Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants; Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Non-reactive Positive for Barbiturates (BAR) Positive for Barbiturates (BAR) Non-reactive Non-reactive Non-reactive Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants; Oxaprozin (Daypro), Sertraline
Chlorhexidine Gluconate
Chlorpheniramine Maleate Chlorpromazine Cimetidine Clobazam
Clonazepam
Clorazepate
Citalopram Co-Amoxiclav Codeine Phosphate
Co-Fluampicil Co-Phenotrope (atropine/diphenoxylate) Delorazepam
Dexamethasone
Dextroamphetamine Dextropropoxyphene Diazepam
Diclofenac Sodium Diclomine Dihydrocodeine Dimethicone Diphenhydramine Dipenoxylate with Atropine Dothiepin Doxycycline
Bactgras, Cordsodyl, Chlorohex, CX Powder, Dermol, Hibicet, Hibiscrub, Hibisol, Hibitane, Instillagel, Naseptin, Nystaform, Serotulle, Steripod, Tisept, Unisept, Uriflex, Uro-Trainer Galpseud, Haymine, Piriton Largactil Dyspamet, Tagamet, Zita Frisium
Clonopin, Klonopin, Rivotril
Tranxene
Cipramil Augmentin, Augmentin Duo Codafen, Continus, Codeine Linctus, Pediatric BP, Galcodine, Kapake, Migraleve, Solpadol, Tylex Magnapen Lomotil, Trepergen
Non-reactive
Non-reactive Non-reactive Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants: Dihydrocodeine Non-reactive Non-reactive
Briantum
Decadron, Dexa-Rhinaspray Suo, Maxidex, Maxidrol, Minims, Otomize, Sofradex Adderall, Adderall XR, Dexedrine Darvon, Darvocet, Co-proximal Diazemuls, Stesolid, Valclair, Valium
Dicloflex, Diclomax, Motifene, Volraman, Volsaid, Voltarol Kolanticon, Merbentyl DHC Continus, Paramol, Remedeine, Remedeine Forte Asilone, Fancorsil Benadryl, Medinex, Nytol, Panadol Night Lomotil Prothiaden Vibramycin, Vibramycin-D
Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive
Positive for Amphetamine (AMP) Positive for Propoxyphene (PPX) Positive for Benzidiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive
Non-reactive Potential Positive for Opiates (OPI, MOR/MOP) Non-reactive Non-reactive
Non-reactive Non-reactive Non-reactive
Doxepin Efavirenz Erythromycin
Estazolam
Ethambutol Ethylmorphine
Flucloxacillin Flunitrazepam
Fluoxetine Flupentixol Fusidic Acid (Sodium Fusidate) Gentamicin Sulphate Hydrocodone
Hydrocortisone Hydrocortisone-17 butyrate Hydromorphone
Hydroxychlorquine Hydroxyzine Hydrochloride Hyoscine butylbromide Ibuprofen Indomethacin Interferon Alfa Isoniazide Isosorbide Dinitrate Koalin and Morphine Mixture
Ketoprofen Lactulose
Sinequan, Xepin Sustiva Arpimycin, Benzymycin, Erycane, Erymax, Erythrocin, Erythroped, Ilosone, Isotrexin, Lactobinate, Stiemycin, Tiloryth, Zineryl ProSom
Myambutol
Co-fluampicil, Floxapen, Magnapen Rohypnol
Prozac, Sarafem Depixol, Fluanxol Fucithalmic, Fucibet, Fucidin Cidomycin, Genticin, Gentisone Lorcet, Loratab, Vicodin
Locoid, Locoid C Dilaudid, Hydrostat
Plaquenil Atarax, Ucerax Busocopan, Scopoderm Flexin continus, Indocid, Indomod Roferon-A, Intron A, Viraferon, Wellferon INH Diocalm, Entersan, Opazimes
Orudis, Oruvail, Powergel Lactugel, Duphalec
Positive for Tricyclic Antidepressants (TCA) Potential Positive for Marijuana (THC) Non-reactive
Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants: Dihydrocodeine Non-reactive
Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Non-reactive Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants: Dihydrocodeine Non-reactive Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants: Dihydrocodeine Non-reactive Non-reactive Non-reactive Non-reactive Non-reactive Non-reactive
Non-reactive Non-reactive Positive for Opiates (OPI, MOR/MOP) Potential cross reactants; Dihydrocodeine Non-reactive Non-reactive
Lamotrigine Lansoprazole Lisinopril HCl Lofepramine Lofexidine Loperamide HCl Loratadine Lorazepam
Lormetazepam
Magnesium Alginate Mannitol Medazepam
Mefenamic Acid Meperidine Metoclopramide Methadone Hydrochloride
d-Methamphetamine HCl
I-Methamphetamine HCL
Methylenedioxyamphetamine (MDA)
Metronidazole
Lamitcal Heliclear, Zoton Carace, Zestril, Zestoretic Gamanil, Lomont Britoflex Imodium, Loperagen, Norimide Claritin Ativan
Noctamide
Gaviscon Gaviscon Anxitol, Lerisum, Medacepan, Nobritol, Nobrium Ponstan, Ponstel Demerol, Pethidine Reglan Dolophine, Methadose, Physetone Desoxyn, Methedrine, Methamprex
Vick's Inhaler
Eve (slang), Love Drug (slang)
Anabact, Elyzol, Flagyl, Metrogel, Metrolyl, Metrotop, Neuratop, Noritate, Rozex, Zidoval, Zymoet
Potential Positive for PCP Non-reactive Non-reactive Positive for Tricyclic Antidepressants (TCA) Non-reactive Non-reactive Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Positive for Benzodiazepines (BZO) Potential cross reactants: Oxaprozin (Daypro), Sertraline Non-reactive Non-reactive Non-reactive Positive for Methadone (MTD) Potential cross reactants: Doxylamine Postive for Methamphetamine (mAMP) Potential cross reactants: Epherdrine, Pseudoephedrine, Phenylpropanolamine, Phentermine, Phenmetrazine, Ranitidine Positive for Methamphetamine (mAMP) Potential cross reactants: Epherdrine, Pseudoephedrine, Phenylpropanolamine, Phentermine, Phenmetrazine, Ranitidine Positive for Amphetamine (AMP) Potential cross reactants: Epherdrine, Pseudoephedrine, Phenylpropanolamine, Phentermine, Phenmetrazine, Ranitidine Non-reactive
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