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Supplementary materialsSupplementary Table 1: Default inputs for TEAE of grade 3 or higher from selinexor occurring in at least 5% of patients ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"u8B3Khq8","properties":{"formattedCitation":"\\super 1\\nosupersub{}","plainCitation":"1","noteIndex":0},"citationItems":[{"id":413,"uris":[""],"uri":[""],"itemData":{"id":413,"type":"article","title":"Karyopharm Therapeutics, Inc. KCP-330-012 CSR. Data on file. 2018b"}}],"schema":""} 1 TEAE TEAE, n (%)(N=123a)Cost per TEAEbBlood and lymphatic system disordersThrombocytopeniac 72 (58.5)$0.79Anemia 52 (42.3)$559.38Neutropenia 27 (22.0)$15.84Leukopenia 15 (12.2)$15.84Lymphopenia 14 (11.4)$23.76Gastrointestinal disordersNausea 12 (9.8)$611.82Diarrhea 9 (7.3)$823.56General disorders and administration site conditionsFatigue 24 (19.5)$74.16Asthenia 7 (5.7)$74.16Infection and infestationPneumonia 13 (10.6)$9,077.30Sepsis 12 (9.8)$12,184.45Metabolism and nutrition disordersHyponatremia 25 (20.3)$833.15Hypokalemia 7 (5.7)$794.27a TEAEs reported from the STORM clinical study report were limited to those occurring in at least 5% of patients at grade 3 or higher, among TEAEs occurring in at least 2% of patients. ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"HXIHhkqw","properties":{"formattedCitation":"\\super 1\\nosupersub{}","plainCitation":"1","noteIndex":0},"citationItems":[{"id":413,"uris":[""],"uri":[""],"itemData":{"id":413,"type":"article","title":"Karyopharm Therapeutics, Inc. KCP-330-012 CSR. Data on file. 2018b"}}],"schema":""} 1 b See Supplementary Table 2 for calculations. c The costs of romiplostim and eltrombopag were not included in the cost of treating thrombocytopenia at this time as these medications are not currently indicated for patients with myeloma with thrombocytopenia.Supplementary Table 2: Estimation of cost per TEAE of grade 3 or higher from selinexor occurring in at least 5% of patients ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"2VBRsUma","properties":{"unsorted":true,"formattedCitation":"\\super 2\\uc0\\u8211{}4\\nosupersub{}","plainCitation":"2–4","noteIndex":0},"citationItems":[{"id":409,"uris":[""],"uri":[""],"itemData":{"id":409,"type":"article","title":"HCUPnet, Healthcare Cost and Utilization Project. Agency for Healthcare Research and Quality, Rockville, MD","URL":"","accessed":{"date-parts":[["2018",12,18]]}},"label":"page"},{"id":391,"uris":[""],"uri":[""],"itemData":{"id":391,"type":"article","title":"Bureau of Economic Analysis, 2018: Table 2.4.4U. Price Indexes for Personal Consumption Expenditures by Type of Product","issued":{"date-parts":[["2018",12,21]]}},"label":"page"},{"id":425,"uris":[""],"uri":[""],"itemData":{"id":425,"type":"article","publisher":"U.S. Department of Health and Human Services","title":"The 2011 National Blood Collection and Utilization Survey Report","URL":"","accessed":{"date-parts":[["2019",2,1]]}},"label":"page"}],"schema":""} 2–4TEAE Resources used for treatment and follow-upUnit cost (cost per resource)Blood and lymphatic system disordersThrombocytopenia1 complete blood count (10% of patients)$7.92aAnemia2 blood transfusions2 bags of packed RBCs (1 per transfusion)1 complete blood count$36.00a$239.73b$7.92aNeutropenia2 complete blood counts$7.92aLeukopenia2 complete blood counts$7.92aLymphopenia3 complete blood counts$7.92aGastrointestinal disordersNausea1 physician visitintravenous fluids at physician visit (90% of patients)1 inpatient hospitalization for nausea (10% of patients)$74.16a$47.52a$4,949cDiarrhea1 physician visitintravenous fluids at physician visit (90% of patients)1 inpatient hospitalization for diarrhea (10% of patients)$74.16a$47.52a$7,066cGeneral disorders and administration site conditionsFatigue1 physician visit$74.16aAsthenia1 physician visit$74.16aInfection and infestationPneumonia1 inpatient hospitalization for pneumonia$9,077cSepsis1 inpatient hospitalization for sepsis$12,184cMetabolism and nutrition disordersHyponatremia1 physician visit1 additional physician visit (50% of patients)1 electrolyte panelintravenous fluids (sodium) (50% of patients)1 inpatient hospitalization for hyponatremia$74.16a$8.64a$47.52a$6,895cHypokalemia1 physician visit1 additional physician visit (50% of patients)1 electrolyte panelintravenous fluids (potassium) (50% of patients)1 inpatient hospitalization for hypokalemia (10% of patients)1 electrocardiogram (50% of patients)$74.16a$8.64a$47.52a$6,420c$17.28aAll costs inflated to 2018 values using PCE inflation index. ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"QYiHGQ6X","properties":{"formattedCitation":"\\super 3\\nosupersub{}","plainCitation":"3","noteIndex":0},"citationItems":[{"id":391,"uris":[""],"uri":[""],"itemData":{"id":391,"type":"article","title":"Bureau of Economic Analysis, 2018: Table 2.4.4U. Price Indexes for Personal Consumption Expenditures by Type of Product","issued":{"date-parts":[["2018",12,21]]}}}],"schema":""} 3 Unless otherwise noted, 100% of patients with the TEAE used each resource. CPT=current procedural terminology; ICD=International Statistical Classification of Diseases; PCE=personal consumption expenditure; RBC=red blood cells; TEAE=treatment-emergent adverse event.a CPT codes: blood transfusion, 36430; electrolyte panel, 80051; complete blood count, 85027; electrocardiogram, 93000; intravenous infusion 31 minutes to 1 hour (hydration, sodium, or potassium), 96360; outpatient visit (15 minutes), 99213. ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"YNJvG7VK","properties":{"formattedCitation":"\\super 5\\nosupersub{}","plainCitation":"5","noteIndex":0},"citationItems":[{"id":397,"uris":[""],"uri":[""],"itemData":{"id":397,"type":"article","publisher":"Utah: OptumInsight, Inc.","title":"Essential RBRVS 2018: A comprehensive listing of RBRVS values for CPT and HCPCS codes.","issued":{"date-parts":[["2018"]]}}}],"schema":""} 5 b 2011 national blood collection and survey report by US Department of Health and Human Services. ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"G3fsQz45","properties":{"formattedCitation":"\\super 4\\nosupersub{}","plainCitation":"4","noteIndex":0},"citationItems":[{"id":425,"uris":[""],"uri":[""],"itemData":{"id":425,"type":"article","publisher":"U.S. Department of Health and Human Services","title":"The 2011 National Blood Collection and Utilization Survey Report","URL":"","accessed":{"date-parts":[["2019",2,1]]}}}],"schema":""} 4 c ICD-9 codes: Nausea, 787.03; Diarrhea, 787.91; Pneumonia, 486; Sepsis, 995.91; Hyponatremia, 276.1; Hypokalemia, 276.8. ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"8eKnpXo1","properties":{"formattedCitation":"\\super 2\\nosupersub{}","plainCitation":"2","noteIndex":0},"citationItems":[{"id":409,"uris":[""],"uri":[""],"itemData":{"id":409,"type":"article","title":"HCUPnet, Healthcare Cost and Utilization Project. Agency for Healthcare Research and Quality, Rockville, MD","URL":"","accessed":{"date-parts":[["2018",12,18]]}}}],"schema":""} 2Supplementary Table 3: One-way sensitivity analysis results for a private payerInput parameterDefault estimateLow valueHigh valueBudget impact in the first yearSpanLowHighUptake of selinexor in year 1 after market entry 28.0%25.2%30.8%$48,876.82 $59,738.33 $10,861.51 Time on treatment with selinexor, weeks 8.07.28.8$49,195.33 $59,419.81 $10,224.48 Cost of selinexor package $22,000.00$19,800.00$24,200.00$49,204.53 $59,410.62 $10,206.09 References ADDIN ZOTERO_BIBL {"uncited":[],"omitted":[],"custom":[]} CSL_BIBLIOGRAPHY 1. Karyopharm Therapeutics, Inc. KCP-330-012 CSR. Data on file. 2018b.2. HCUPnet, Healthcare Cost and Utilization Project. Agency for Healthcare Research and Quality, Rockville, MD. . Accessed December 18, 2018.3. Bureau of Economic Analysis, 2018: Table 2.4.4U. Price Indexes for Personal Consumption Expenditures by Type of Product. December 2018.4. The 2011 National Blood Collection and Utilization Survey Report. . Accessed February 1, 2019.5. Essential RBRVS 2018: A comprehensive listing of RBRVS values for CPT and HCPCS codes. 2018. ................
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