Angiotensin Converting Enzyme 2: A Double-Edged Sword
Cleavage of angiotensin I by ACE generates angiotensin II, which is the primary effector peptide of the ACE/angiotensin II/AT 1 receptor axis, triggering potent vasoconstriction, inflammation, cell proliferation, hypertrophy, fibrosis, and tissue remodeling. ACE2 cleaves angiotensin II into the cardioprotective angiotensin 1–7, which acts ... ................
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