Pennsylvania State University



The Secret to Lean, Dry Muscle Gains: EpistaneEpistane: Epistane is a dihydrotestosterone clone that shares much of the same characteristics as the Japanese anti-estrogen drug epitiostanol. With a chemical structure of 2a,3a-EPITHIO-5a-ANDROSTAN-17B-OL, epistane is considered a sulfur containing steroid that is known to haverightcenter00 strong and long-lasting anti-estrogenic activity. On paper, the compound has a 1100:91 anabolic to androgenic rating, and thanks to its DHT structure, will not aromatize into estrogen. What is Epistane used for?Mistaken as an anti-estrogen compound due to the supplement’s ability to lower estrogen levels, Epi is primarily used as an anabolic agent that delivers dry, lean muscle gain, and works hand-in-hand with a cutting cycle. Considered a mild compound, epi causes lean growth without being too harsh of an androgen, resulting in less severe side effects compared to more aggressive androgenic compounds such as halodrol or dimethylzene. Looking at the supplement’s “myotropic ratio, epi presents itself in a way that is more anabolic rather than androgenic when attaching to receptor sites in the muscle cells, resulting in an increase in protein synthesis and nitrogen retention” (Gemelli). How Epistane increases lean muscle mass: As an aromatase inhibitor, the compound binds to androgen receptors in skeletal and muscle stem cells. The site then creates a signal to the cell that causes growth through increased androgen activity. The active muscles then increase the potential for growth and repair, resulting in an increase in mass while also decreasing the body’s ability to store fat cells. Since the presence of androgens in the stem cells hinders fat cell production, one will also see more positive effects of nutrition and training, resulting in minimal fat gain. Regarding bioavailability, epistane’s half-life of six hours requires a split dosing between morning and evening with a recommendation to take the supplement with a food containing high healthy fats such as peanut butter. Cycling Epistane: Normal dose cycles for the prohormone consist of a shortened four-week “competition” phase or an extended 45 day cutting phase. Most dosages run through 15mg capsules that are split in am/pm consumption. When running a more aggressive cycle, users often take 15mg doses right after waking up, between meals, and right before going to bed. Recommended Dosage: “Competition” Phase, 90 15mg CapsulesWeekMondayTuesdayWednesdayThursdayFridaySaturdaySunday130 mg 30 mg30 mg30 mg30 mg30 mg30 mg245mg 45 mg45 mg45 mg45 mg45 mg45 mg345 mg45 mg45 mg45 mg45 mg45 mg45 mg460 mg60 mg60 mg 60 mg60 mg60 mg60 mgA four-week competition cycle focuses mainly on hard muscle gains with a recommended calorie increase to sustain desired growth. Protein consumption for the phase follows the formula: (grams of protein consumed) = (body weight)*1.5.Expected Results: Users who run the “competition” cycle will likely see lean muscle mass increases upwards of 10-15lbs over the course of four weeks. Average consumers also reported body fat loss between 4-8%.Recommended Dosage: “Cutting” Phase, 90 15mg CapsulesWeekMondayTuesdayWednesdayThursdayFridaySaturdaySunday115mg15mg15mg15mg15mg15mg15mg230mg30mg30mg30mg30mg30mg30mg330mg30mg30mg30mg30mg30mg30mg430mg30mg30mg30mg30mg30mg30mg545mg45mg45mg45mg45mg45mg45mg645mg45mg45mg30mg30mg30mg30mg7 (42-45)15mg15mg15mg----A 45 day cutting cycle focuses mainly on fat loss and lean muscle growth with minimal fat retention. Cycle recommendations include running a small calorie deficit (~500 calories) from normal caloric intake, while replacing carbs with increased protein use. Protein consumption follows the formula: (grams of protein consumed) = (body weight)*0.75.Expected Results: Users who run the “cutting” cycle will likely see fat loss between 3-7% while averaging muscle gain of 6-10lbs. 45 day cycles also illustrate less side effects such as acne, hair loss, and overall joint pain. Warning:Due to epistane’s liver toxicity, one may want to consult a physician before attempting to run a supplement cycle. If you are able to purchase real epistane, not the 17a-methyl clone that many companies are pushing in today’s supplement industry, you should not see any estrogenic or progesterone side effects but may experience slight hair loss, dry joints, and painful back pumps throughout the course of the cycle. Epsitane will also have a negative impact on good cholesterol, blood lipids, blood pressure, and overall liver health. Also, being largely anabolic, the supplement is very likely to cause some lethargy and increased water retention.Presenting in rare cases, a user of an epistane cycle may experience a symptom known as gynecomastia or test positive for anabolic steroids through pheraplex conversion.Gynecomastia: Known in the body-building world as Gyno, gynecomastia begins with sore or swollen breasts and itchy nipples. If not controlled however, one may need surgery to correct the side effects. In extreme cases, men have presented with lactation (milk excreting from their nipples). Although gyno is a pretty serious side effect, some users with gyno problems said that symptoms stopped immediately after the use of epistane was discontinued. Pheraplex: Real epistane should not convert to this compound and should always be a very, dry, lean muscle gainer. Inferior product 14a-methyl 2b,3b-epithio 5a-androstane presents itself as an epistane clone, and throughout a cycle presents users with increased bloat and converts to the compound Pheraplex (desoxymethyltestosterone), which is a scheduled anabolic steroid designed by Patrick Arnold to be undetectable in competition drug tests. Stacking:For more advanced prohormone users, epistane is often recommended as a stack with a wet compound such a superdrol or dianabol, which would help sustain strength while running a calorie deficit. In order to achieve the best results, it is often suggested to lose fat and obtain a body fat percentage of 15% or lower. Overall, epistane presents little to no water retention, so if you are expecting to gain mass and move up on the scale you may also want to run a tri-stack with epi, a wet compound, and a testosterone booster to increase overall size. ReferencesGemelli, Dylan. "Epistane." ISARMS. 2016. Web. Feb.-Mar. 2016. < Star. "What Is Epistane?" . 2016. Web. Feb.-Mar. 2016. < ................
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