Michigan Medicine | University of Michigan
POLYMYXIN B SULFATE (generic)DescriptionPEVuZE5vdGU+PENpdGU+PFJlY051bT41ODQ2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBm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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PFJlY051bT41ODQ2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBm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ADDIN EN.CITE.DATA 1-4Polymyxin B is a cyclic polypeptide antimicrobial active against many types of clinically relevant gram-negative bacteria, including multi-drug resistant isolates. Polymyxin B is structurally related to colistin (polymyxin E) but differs in that it is commercially available as active drug while colistin is commercially available as its prodrug, colistimethate sodium. Polymyxin B has five primary amine groups which are protonated and positively charged at physiologic pH and facilitate binding to the negatively charged lipopolysaccharide (LPS) of component of the gram-negative bacterial cell wall. Once bound to LPS, polymyxin B exerts bactericidal antibiotic activity by displacing stabilizing cations and increasing cell wall permeability, ultimately leading to lysis of the bacterial cell. Indications for Use ADDIN EN.CITE <EndNote><Cite><RecNum>5846</RecNum><DisplayText><style face="superscript">1</style></DisplayText><record><rec-number>5846</rec-number><foreign-keys><key app="EN" db-id="9zs5ep0age50piexdt1xs2dmz5r2r2etxsd0" timestamp="1512161919">5846</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>Polymyxin B Sulfate [package insert]. Bedford Laboratories, Bedford, OH; June 2011.</title></titles><dates></dates><urls></urls></record></Cite></EndNote>1Polymyxin B is FDA-approved for the treatment of acute infections caused by susceptible strains of Pseudomonas aeruginosa and for serious infections with susceptible strains of Haemophilus influenzae (specifically meningitis), Escherichia coli (specifically urinary tract infections), Aerobacter [Enterobacter] aerogenes (specifically bacteremia), and Klebsiella pneumoniae (specifically bacteremia).Microbiology ADDIN EN.CITE <EndNote><Cite><RecNum>5847</RecNum><DisplayText><style face="superscript">1,5</style></DisplayText><record><rec-number>5847</rec-number><foreign-keys><key app="EN" db-id="9zs5ep0age50piexdt1xs2dmz5r2r2etxsd0" timestamp="1512162895">5847</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>CLSI. Performance standards for antimicrobial susceptibility testing; twenty-fourth informational supplement M100-S24. Wayne, PA: Clinical and Laboratory Standards Institute; 2012.</title></titles><dates></dates><urls></urls></record></Cite><Cite><RecNum>5846</RecNum><record><rec-number>5846</rec-number><foreign-keys><key app="EN" db-id="9zs5ep0age50piexdt1xs2dmz5r2r2etxsd0" timestamp="1512161919">5846</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>Polymyxin B Sulfate [package insert]. Bedford Laboratories, Bedford, OH; June 2011.</title></titles><dates></dates><urls></urls></record></Cite></EndNote>1,5Polymyxin B displays activity against many clinically important gram-negative bacteria including Pseudomonas aeruginosa, and Acinetobacter baumannii, Escherichia coli, Klebsiella spp, Citrobacter spp, and Enterobacter spp. However, the polymyxins are not universally active against Enterobacteriaceae and non-fermenting gram-negative rods. Important gram-negative species with intrinsic resistance to the polymyxins (polymyxin B and colistin) are listed in Table 1. Polymyxin B does not have activity against gram-positive bacteria or fungi. Table 1: Important Gram-negative bacteria with intrinsic resistance to polymyxinsEnterobacteriaceaeNon-EnterobacteriaceaeMorganella morganiiBurkholderia cepaciaProteus sppProvidencia sppSerratia marcesensPharmacokineticsPEVuZE5vdGU+PENpdGU+PFJlY051bT41ODQ2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBm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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PFJlY051bT41ODQ2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBm
YWNlPSJzdXBlcnNjcmlwdCI+MSwyLDYtMTU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48
cmVjLW51bWJlcj41ODQ2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iOXpzNWVwMGFnZTUwcGlleGR0MXhzMmRtejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE1
MTIxNjE5MTkiPjU4NDY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iV2ViIFBh
Z2UiPjEyPC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRp
dGxlPlBvbHlteXhpbiBCIFN1bGZhdGUgW3BhY2thZ2UgaW5zZXJ0XS4gQmVkZm9yZCBMYWJvcmF0
b3JpZXMsIEJlZGZvcmQsIE9IOyBKdW5lIDIwMTEuPC90aXRsZT48L3RpdGxlcz48ZGF0ZXM+PC9k
YXRlcz48dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxSZWNOdW0+NTg0ODwvUmVj
TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NTg0ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr
ZXkgYXBwPSJFTiIgZGItaWQ9Ijl6czVlcDBhZ2U1MHBpZXhkdDF4czJkbXo1cjJyMmV0eHNkMCIg
dGltZXN0YW1wPSIxNTEyMTYzMDk1Ij41ODQ4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl
IG5hbWU9IldlYiBQYWdlIj4xMjwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48L2NvbnRyaWJ1dG9y
cz48dGl0bGVzPjx0aXRsZT5Db2x5LU15Y2luKFIpIE0gW3BhY2thZ2UgaW5zZXJ0XS4gUGFyIFBo
YXJtYWNldXRpY2FsLCBDaGVzdG51dCBSaWRnZSwgTlk7IEFwcmlsIDIwMTcuPC90aXRsZT48L3Rp
dGxlcz48ZGF0ZXM+PC9kYXRlcz48dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB
dXRob3I+U2FuZHJpPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjMxPC9SZWNOdW0+
PHJlY29yZD48cmVjLW51bWJlcj4zMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw
PSJFTiIgZGItaWQ9Ijl6czVlcDBhZ2U1MHBpZXhkdDF4czJkbXo1cjJyMmV0eHNkMCIgdGltZXN0
YW1wPSIxNDQwMjY0NDE2Ij4zMTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK
b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo
b3I+U2FuZHJpLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+TGFuZGVyc2RvcmZlciwgQy4gQi48L2F1
dGhvcj48YXV0aG9yPkphY29iLCBKLjwvYXV0aG9yPjxhdXRob3I+Qm9uaWF0dGksIE0uIE0uPC9h
dXRob3I+PGF1dGhvcj5EYWxhcm9zYSwgTS4gRy48L2F1dGhvcj48YXV0aG9yPkZhbGNpLCBELiBS
LjwvYXV0aG9yPjxhdXRob3I+QmVobGUsIFQuIEYuPC9hdXRob3I+PGF1dGhvcj5Cb3JkaW5oYW8s
IFIuIEMuPC9hdXRob3I+PGF1dGhvcj5XYW5nLCBKLjwvYXV0aG9yPjxhdXRob3I+Rm9ycmVzdCwg
QS48L2F1dGhvcj48YXV0aG9yPk5hdGlvbiwgUi4gTC48L2F1dGhvcj48YXV0aG9yPkxpLCBKLjwv
YXV0aG9yPjxhdXRob3I+WmF2YXNja2ksIEEuIFAuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp
YnV0b3JzPjxhdXRoLWFkZHJlc3M+SW5mZWN0aW91cyBEaXNlYXNlcyBTZXJ2aWNlLCBIb3NwaXRh
bCBTYW8gTHVjYXMgZGEgUG9udGlmaWNpYSBVbml2ZXJzaWRhZGUgQ2F0b2xpY2EgZG8gUmlvIEdy
YW5kZSBkbyBTdWwsIFBvcnRvIEFsZWdyZSwgQnJhemlsLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+
PHRpdGxlPlBvcHVsYXRpb24gcGhhcm1hY29raW5ldGljcyBvZiBpbnRyYXZlbm91cyBwb2x5bXl4
aW4gQiBpbiBjcml0aWNhbGx5IGlsbCBwYXRpZW50czogaW1wbGljYXRpb25zIGZvciBzZWxlY3Rp
b24gb2YgZG9zYWdlIHJlZ2ltZW5zPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gSW5mZWN0
IERpczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNs
aW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjUyNC0zMTwvcGFn
ZXM+PHZvbHVtZT41Nzwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29y
ZD5BZG1pbmlzdHJhdGlvbiwgSW50cmF2ZW5vdXM8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tl
eXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwv
a2V5d29yZD48a2V5d29yZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvKmFkbWluaXN0cmF0aW9uICZh
bXA7IGRvc2FnZS9ibG9vZC8qcGhhcm1hY29raW5ldGljcy91cmluZTwva2V5d29yZD48a2V5d29y
ZD5CbG9vZCBDaGVtaWNhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5Cb2R5IFdlaWdodDwv
a2V5d29yZD48a2V5d29yZD5DaHJvbWF0b2dyYXBoeSwgTGlxdWlkPC9rZXl3b3JkPjxrZXl3b3Jk
PkNyaXRpY2FsIElsbG5lc3M8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3
b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRs
ZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHlteXhpbiBCLyphZG1pbmlzdHJhdGlvbiAmYW1w
OyBkb3NhZ2UvYmxvb2QvKnBoYXJtYWNva2luZXRpY3MvdXJpbmU8L2tleXdvcmQ+PGtleXdvcmQ+
VGFuZGVtIE1hc3MgU3BlY3Ryb21ldHJ5PC9rZXl3b3JkPjxrZXl3b3JkPlVyaW5lL2NoZW1pc3Ry
eTwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVsdDwva2V5d29yZD48a2V5d29yZD5kb3NlIHNl
bGVjdGlvbjwva2V5d29yZD48a2V5d29yZD5waGFybWFjb2tpbmV0aWNzPC9rZXl3b3JkPjxrZXl3
b3JkPnBsYXNtYSBwcm90ZWluIGJpbmRpbmc8L2tleXdvcmQ+PGtleXdvcmQ+cG9seW15eGluczwv
a2V5d29yZD48a2V5d29yZD51cmluYXJ5IHJlY292ZXJ5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRh
dGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWc8L2RhdGU+PC9wdWItZGF0
ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExp
bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzNjk3NzQ0PC9hY2Nlc3Npb24tbnVtPjx1cmxz
PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIz
Njk3NzQ0PC91cmw+PHVybD5odHRwOi8vY2lkLm94Zm9yZGpvdXJuYWxzLm9yZy9jb250ZW50LzU3
LzQvNTI0LmZ1bGwucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJl
c291cmNlLW51bT4xMC4xMDkzL2NpZC9jaXQzMzQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv
cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkdhcm9uemlrPC9BdXRob3I+PFllYXI+MjAxMTwv
WWVhcj48UmVjTnVtPjI4PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yODwvcmVjLW51bWJl
cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9Ijl6czVlcDBhZ2U1MHBpZXhkdDF4
czJkbXo1cjJyMmV0eHNkMCIgdGltZXN0YW1wPSIxNDQwMjY0MzI5Ij4yODwva2V5PjwvZm9yZWln
bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u
dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R2Fyb256aWssIFMuIE0uPC9hdXRob3I+PGF1dGhv
cj5MaSwgSi48L2F1dGhvcj48YXV0aG9yPlRoYW1saWtpdGt1bCwgVi48L2F1dGhvcj48YXV0aG9y
PlBhdGVyc29uLCBELiBMLjwvYXV0aG9yPjxhdXRob3I+U2hvaGFtLCBTLjwvYXV0aG9yPjxhdXRo
b3I+SmFjb2IsIEouPC9hdXRob3I+PGF1dGhvcj5TaWx2ZWlyYSwgRi4gUC48L2F1dGhvcj48YXV0
aG9yPkZvcnJlc3QsIEEuPC9hdXRob3I+PGF1dGhvcj5OYXRpb24sIFIuIEwuPC9hdXRob3I+PC9h
dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2Nob29sIG9mIFBoYXJtYWN5IGFu
ZCBQaGFybWFjZXV0aWNhbCBTY2llbmNlcywgVW5pdmVyc2l0eSBhdCBCdWZmYWxvLCBTVU5ZLCBC
dWZmYWxvLCBOZXcgWW9yaywgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBvcHVs
YXRpb24gcGhhcm1hY29raW5ldGljcyBvZiBjb2xpc3RpbiBtZXRoYW5lc3VsZm9uYXRlIGFuZCBm
b3JtZWQgY29saXN0aW4gaW4gY3JpdGljYWxseSBpbGwgcGF0aWVudHMgZnJvbSBhIG11bHRpY2Vu
dGVyIHN0dWR5IHByb3ZpZGUgZG9zaW5nIHN1Z2dlc3Rpb25zIGZvciB2YXJpb3VzIGNhdGVnb3Jp
ZXMgb2YgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW50aW1pY3JvYiBBZ2VudHMg
Q2hlbW90aGVyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0
bGU+QW50aW1pY3JvYiBBZ2VudHMgQ2hlbW90aGVyPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48
cGFnZXM+MzI4NC05NDwvcGFnZXM+PHZvbHVtZT41NTwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVy
PjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3Jk
PjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkFudGktQmFjdGVy
aWFsIEFnZW50cy9ibG9vZC8qcGhhcm1hY29raW5ldGljczwva2V5d29yZD48a2V5d29yZD5Db2xp
c3Rpbi8qYW5hbG9ncyAmYW1wOyBkZXJpdmF0aXZlcy9ibG9vZC8qcGhhcm1hY29raW5ldGljczwv
a2V5d29yZD48a2V5d29yZD4qQ3JpdGljYWwgSWxsbmVzczwva2V5d29yZD48a2V5d29yZD5GZW1h
bGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdv
cmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+WW91bmcgQWR1bHQ8L2tl
eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRl
Pkp1bDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgtNjU5NiAoRWxlY3Ryb25p
YykmI3hEOzAwNjYtNDgwNCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE1NTU3NjM8
L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5u
bG0ubmloLmdvdi9wdWJtZWQvMjE1NTU3NjM8L3VybD48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0u
bmloLmdvdi9wbWMvYXJ0aWNsZXMvUE1DMzEyMjQ0MC9wZGYvemFjMzI4NC5wZGY8L3VybD48L3Jl
bGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DMzEyMjQ0MDwvY3VzdG9tMj48ZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+MTAuMTEyOC9BQUMuMDE3MzMtMTA8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut
bnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPk5hdGlvbjwvQXV0aG9yPjxZZWFyPjIw
MTY8L1llYXI+PFJlY051bT4yNTQ1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yNTQ1PC9y
ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVwMGFnZTUw
cGlleGR0MXhzMmRtejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE0ODUzOTIzMTUiPjI1NDU8L2tl
eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm
LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk5hdGlvbiwgUi4gTC48L2F1dGhv
cj48YXV0aG9yPkdhcm9uemlrLCBTLiBNLjwvYXV0aG9yPjxhdXRob3I+VGhhbWxpa2l0a3VsLCBW
LjwvYXV0aG9yPjxhdXRob3I+R2lhbWFyZWxsb3MtQm91cmJvdWxpcywgRS4gSi48L2F1dGhvcj48
YXV0aG9yPkZvcnJlc3QsIEEuPC9hdXRob3I+PGF1dGhvcj5QYXRlcnNvbiwgRC4gTC48L2F1dGhv
cj48YXV0aG9yPkxpLCBKLjwvYXV0aG9yPjxhdXRob3I+U2lsdmVpcmEsIEYuIFAuPC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RHJ1ZyBEZWxpdmVyeSwgRGlz
cG9zaXRpb24gYW5kIER5bmFtaWNzLCBNb25hc2ggSW5zdGl0dXRlIG9mIFBoYXJtYWNldXRpY2Fs
IFNjaWVuY2VzLCBNb25hc2ggVW5pdmVyc2l0eSwgTWVsYm91cm5lLCBBdXN0cmFsaWEgcm9nZXIu
bmF0aW9uQG1vbmFzaC5lZHUuJiN4RDtTY2hvb2wgb2YgUGhhcm1hY3kgYW5kIFBoYXJtYWNldXRp
Y2FsIFNjaWVuY2VzLCBVbml2ZXJzaXR5IGF0IEJ1ZmZhbG8sIFNVTlksIEJ1ZmZhbG8sIE5ZLiYj
eEQ7RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcyBhbmQgVHJvcGljYWwgTWVkaWNpbmUs
IEZhY3VsdHkgb2YgTWVkaWNpbmUgU2lyaXJhaiBIb3NwaXRhbCwgTWFoaWRvbCBVbml2ZXJzaXR5
LCBCYW5na29rLCBUaGFpbGFuZC4mI3hEOzQgRGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2lu
ZSwgVW5pdmVyc2l0eSBvZiBBdGhlbnMsIE1lZGljYWwgU2Nob29sLCBHcmVlY2UuJiN4RDtUaGUg
VW5pdmVyc2l0eSBvZiBRdWVlbnNsYW5kIENlbnRlciBmb3IgQ2xpbmljYWwgUmVzZWFyY2gsIFJv
eWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEJyaXNiYW5lLCBBdXN0cmFs
aWEuJiN4RDtEcnVnIERlbGl2ZXJ5LCBEaXNwb3NpdGlvbiBhbmQgRHluYW1pY3MsIE1vbmFzaCBJ
bnN0aXR1dGUgb2YgUGhhcm1hY2V1dGljYWwgU2NpZW5jZXMsIE1vbmFzaCBVbml2ZXJzaXR5LCBN
ZWxib3VybmUsIEF1c3RyYWxpYS4mI3hEO0RpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMs
IFVuaXZlcnNpdHkgb2YgUGl0dHNidXJnaCBNZWRpY2FsIENlbnRlciwgUGl0dHNidXJnaCwgUEEu
PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RG9zaW5nIGd1aWRhbmNlIGZvciBpbnRyYXZl
bm91cyBjb2xpc3RpbiBpbiBjcml0aWNhbGx5LWlsbCBwYXRpZW50czwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k
aWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2Fs
PjxrZXl3b3Jkcz48a2V5d29yZD5JbnRyYXZlbm91cyBjb2xpc3Rpbjwva2V5d29yZD48a2V5d29y
ZD5jcml0aWNhbGx5LWlsbCBwYXRpZW50czwva2V5d29yZD48a2V5d29yZD5kb3NpbmcgZ3VpZGFu
Y2U8L2tleXdvcmQ+PGtleXdvcmQ+aW5mbHVlbmNlIG9mIHJlbmFsIGltcGFpcm1lbnQgYW5kIHJl
bmFsIHJlcGxhY2VtZW50IG1vZGFsaXRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+cG9wdWxhdGlvbiBw
aGFybWFjb2tpbmV0aWNzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTY8L3ll
YXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWMgMjM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNi
bj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxh
Y2Nlc3Npb24tbnVtPjI4MDExNjE0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+
PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI4MDExNjE0PC91cmw+PHVy
bD5odHRwczovL2FjYWRlbWljLm91cC5jb20vY2lkL2FydGljbGUtYWJzdHJhY3QvZG9pLzEwLjEw
OTMvY2lkL2NpdzgzOS8yNzM2NzU4L0Rvc2luZy1ndWlkYW5jZS1mb3ItaW50cmF2ZW5vdXMtY29s
aXN0aW4taW4/cmVkaXJlY3RlZEZyb209ZnVsbHRleHQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy
bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvY2lkL2NpdzgzOTwvZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+WmF2YXNja2k8L0F1
dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxSZWNOdW0+NDI5MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u
dW1iZXI+NDI5MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9
Ijl6czVlcDBhZ2U1MHBpZXhkdDF4czJkbXo1cjJyMmV0eHNkMCIgdGltZXN0YW1wPSIxNTAyNzU2
MzI5Ij40MjkxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0
aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5aYXZhc2Nr
aSwgQS4gUC48L2F1dGhvcj48YXV0aG9yPkdvbGRhbmksIEwuIFouPC9hdXRob3I+PGF1dGhvcj5D
YW8sIEcuPC9hdXRob3I+PGF1dGhvcj5TdXBlcnRpLCBTLiBWLjwvYXV0aG9yPjxhdXRob3I+THV0
eiwgTC48L2F1dGhvcj48YXV0aG9yPkJhcnRoLCBBLiBMLjwvYXV0aG9yPjxhdXRob3I+UmFtb3Ms
IEYuPC9hdXRob3I+PGF1dGhvcj5Cb25pYXR0aSwgTS4gTS48L2F1dGhvcj48YXV0aG9yPk5hdGlv
biwgUi4gTC48L2F1dGhvcj48YXV0aG9yPkxpLCBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy
aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIEhv
c3BpdGFsIGRlIENsaW5pY2FzIGRlIFBvcnRvIEFsZWdyZSwgUG9ydG8gQWxlZ3JlLCBCcmF6aWwu
PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGhhcm1hY29raW5ldGljcyBvZiBpbnRyYXZl
bm91cyBwb2x5bXl4aW4gQiBpbiBjcml0aWNhbGx5IGlsbCBwYXRpZW50czwvdGl0bGU+PHNlY29u
ZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVy
aW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp
Y2FsPjxwYWdlcz4xMjk4LTMwNDwvcGFnZXM+PHZvbHVtZT40Nzwvdm9sdW1lPjxudW1iZXI+MTA8
L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwv
a2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5BbnRp
LUJhY3RlcmlhbCBBZ2VudHMvYWR2ZXJzZSBlZmZlY3RzLypwaGFybWFjb2tpbmV0aWNzPC9rZXl3
b3JkPjxrZXl3b3JkPkNocm9tYXRvZ3JhcGh5LCBIaWdoIFByZXNzdXJlIExpcXVpZDwva2V5d29y
ZD48a2V5d29yZD5Dcml0aWNhbCBJbGxuZXNzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5
d29yZD48a2V5d29yZD5HcmFtLU5lZ2F0aXZlIEJhY3RlcmlhbCBJbmZlY3Rpb25zL2RydWcgdGhl
cmFweTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mdXNpb25z
LCBJbnRyYXZlbm91czwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1p
ZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBsYXNtYS9jaGVtaXN0cnk8L2tleXdvcmQ+PGtl
eXdvcmQ+UG9seW15eGluIEIvYWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlL2FkdmVyc2UgZWZm
ZWN0cy8qcGhhcm1hY29raW5ldGljczwva2V5d29yZD48a2V5d29yZD5Qcm90ZWluIEJpbmRpbmc8
L2tleXdvcmQ+PGtleXdvcmQ+VXJpbmUvY2hlbWlzdHJ5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRh
dGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3YgMTU8L2RhdGU+PC9wdWIt
ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4Mzgg
KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4ODQwMDc5PC9hY2Nlc3Npb24tbnVtPjx1
cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l
ZC8xODg0MDA3OTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJj
ZS1udW0+MTAuMTA4Ni81OTI1Nzc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwv
Q2l0ZT48Q2l0ZT48QXV0aG9yPlRoYW1saWtpdGt1bDwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+
PFJlY051bT40MjY1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj40MjY1PC9yZWMtbnVtYmVy
Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVwMGFnZTUwcGlleGR0MXhz
MmRtejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE1MDI3NTYxNDYiPjQyNjU8L2tleT48L2ZvcmVp
Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv
bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRoYW1saWtpdGt1bCwgVi48L2F1dGhvcj48YXV0
aG9yPkR1YnJvdnNrYXlhLCBZLjwvYXV0aG9yPjxhdXRob3I+TWFuY2hhbmRhbmksIFAuPC9hdXRo
b3I+PGF1dGhvcj5OZ2FtcHJhc2VydGNoYWksIFQuPC9hdXRob3I+PGF1dGhvcj5Cb29ueWFzaXJp
LCBBLjwvYXV0aG9yPjxhdXRob3I+QmFiaWMsIEouIFQuPC9hdXRob3I+PGF1dGhvcj5UYW0sIFYu
IEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RmFjdWx0
eSBvZiBNZWRpY2luZSBTaXJpcmFqIEhvc3BpdGFsLCBNYWhpZG9sIFVuaXZlcnNpdHksIEJhbmdr
b2ssIFRoYWlsYW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBQaGFybWFjeSwgTmV3IFlvcmsgVW5pdmVy
c2l0eSBMYW5nb25lIE1lZGljYWwgQ2VudGVyLCBOZXcgWW9yaywgTmV3IFlvcmssIFVTQS4mI3hE
O0RlcGFydG1lbnQgb2YgUGhhcm1hY29sb2dpY2FsIGFuZCBQaGFybWFjZXV0aWNhbCBTY2llbmNl
cywgVW5pdmVyc2l0eSBvZiBIb3VzdG9uIENvbGxlZ2Ugb2YgUGhhcm1hY3ksIEhvdXN0b24sIFRl
eGFzLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIFBoYXJtYWN5IFByYWN0aWNlIGFuZCBUcmFuc2xh
dGlvbmFsIFJlc2VhcmNoLCBVbml2ZXJzaXR5IG9mIEhvdXN0b24gQ29sbGVnZSBvZiBQaGFybWFj
eSwgSG91c3RvbiwgVGV4YXMsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgUGhhcm1hY3ksIEJheWxv
ciBTdC4gTHVrZSZhcG9zO3MgTWVkaWNhbCBDZW50ZXIsIEhvdXN0b24sIFRleGFzLCBVU0EuJiN4
RDtEZXBhcnRtZW50IG9mIFBoYXJtYWNvbG9naWNhbCBhbmQgUGhhcm1hY2V1dGljYWwgU2NpZW5j
ZXMsIFVuaXZlcnNpdHkgb2YgSG91c3RvbiBDb2xsZWdlIG9mIFBoYXJtYWN5LCBIb3VzdG9uLCBU
ZXhhcywgVVNBIHZ0YW1AdWguZWR1LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkRvc2lu
ZyBhbmQgUGhhcm1hY29raW5ldGljcyBvZiBQb2x5bXl4aW4gQiBpbiBQYXRpZW50cyB3aXRoIFJl
bmFsIEluc3VmZmljaWVuY3k8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW50aW1pY3JvYiBBZ2Vu
dHMgQ2hlbW90aGVyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt
dGl0bGU+QW50aW1pY3JvYiBBZ2VudHMgQ2hlbW90aGVyPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh
bD48dm9sdW1lPjYxPC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3Jk
PmRvc2luZyBhZGp1c3RtZW50PC9rZXl3b3JkPjxrZXl3b3JkPmRydWcgZXhwb3N1cmU8L2tleXdv
cmQ+PGtleXdvcmQ+cG9seW15eGluczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y
MDE3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+
PGlzYm4+MTA5OC02NTk2IChFbGVjdHJvbmljKSYjeEQ7MDA2Ni00ODA0IChMaW5raW5nKTwvaXNi
bj48YWNjZXNzaW9uLW51bT4yNzc5OTIwOTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11
cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjc3OTkyMDk8L3Vy
bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNTE5MjE2MjwvY3VzdG9tMj48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEyOC9BQUMuMDEzMzctMTY8L2VsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNhbmRyaTwvQXV0aG9yPjxZ
ZWFyPjIwMTM8L1llYXI+PFJlY051bT40Mjk1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj40
Mjk1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVw
MGFnZTUwcGlleGR0MXhzMmRtejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE1MDI3NTY1NjgiPjQy
OTU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x
NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNhbmRyaSwgQS4gTS48
L2F1dGhvcj48YXV0aG9yPkxhbmRlcnNkb3JmZXIsIEMuIEIuPC9hdXRob3I+PGF1dGhvcj5KYWNv
YiwgSi48L2F1dGhvcj48YXV0aG9yPkJvbmlhdHRpLCBNLiBNLjwvYXV0aG9yPjxhdXRob3I+RGFs
YXJvc2EsIE0uIEcuPC9hdXRob3I+PGF1dGhvcj5GYWxjaSwgRC4gUi48L2F1dGhvcj48YXV0aG9y
PkJlaGxlLCBULiBGLjwvYXV0aG9yPjxhdXRob3I+U2FpdG92aXRjaCwgRC48L2F1dGhvcj48YXV0
aG9yPldhbmcsIEouPC9hdXRob3I+PGF1dGhvcj5Gb3JyZXN0LCBBLjwvYXV0aG9yPjxhdXRob3I+
TmF0aW9uLCBSLiBMLjwvYXV0aG9yPjxhdXRob3I+WmF2YXNja2ksIEEuIFAuPC9hdXRob3I+PGF1
dGhvcj5MaSwgSi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz
cz5JbmZlY3Rpb3VzIERpc2Vhc2VzIFNlcnZpY2UsIEhvc3BpdGFsIFNhbyBMdWNhcyBkYSBQb250
aWZpY2lhIFVuaXZlcnNpZGFkZSBDYXRvbGljYSBkbyBSaW8gR3JhbmRlIGRvIFN1bCwgUG9ydG8g
QWxlZ3JlLCBCcmF6aWwuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGhhcm1hY29raW5l
dGljcyBvZiBwb2x5bXl4aW4gQiBpbiBwYXRpZW50cyBvbiBjb250aW51b3VzIHZlbm92ZW5vdXMg
aGFlbW9kaWFseXNpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEFudGltaWNyb2IgQ2hlbW90
aGVyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBB
bnRpbWljcm9iIENoZW1vdGhlcjwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjY3NC03
PC9wYWdlcz48dm9sdW1lPjY4PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdvcmRzPjxr
ZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFudGktQmFjdGVyaWFsIEFnZW50cy8qYWRt
aW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlLypwaGFybWFjb2tpbmV0aWNzPC9rZXl3b3JkPjxrZXl3
b3JkPkNocm9tYXRvZ3JhcGh5LCBMaXF1aWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q3JpdGljYWwgSWxs
bmVzczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9r
ZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFzcyBTcGVjdHJvbWV0cnk8
L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UGxhc21hL2No
ZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5Qb2x5bXl4aW4gQi8qYWRtaW5pc3RyYXRpb24gJmFt
cDsgZG9zYWdlLypwaGFybWFjb2tpbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlJlbmFsIERpYWx5
c2lzLyptZXRob2RzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+
PHB1Yi1kYXRlcz48ZGF0ZT5NYXI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDYw
LTIwOTEgKEVsZWN0cm9uaWMpJiN4RDswMzA1LTc0NTMgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np
b24tbnVtPjIzMTc5NTYxPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o
dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzE3OTU2MTwvdXJsPjwvcmVsYXRl
ZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9qYWMvZGtzNDM3
PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5N
b2hhbWVkPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVjTnVtPjMwPC9SZWNOdW0+PHJlY29y
ZD48cmVjLW51bWJlcj4zMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9Ijl6czVlcDBhZ2U1MHBpZXhkdDF4czJkbXo1cjJyMmV0eHNkMCIgdGltZXN0YW1wPSIx
NDQwMjY0MzgwIj4zMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TW9o
YW1lZCwgQS4gRi48L2F1dGhvcj48YXV0aG9yPkthcmFpc2tvcywgSS48L2F1dGhvcj48YXV0aG9y
PlBsYWNob3VyYXMsIEQuPC9hdXRob3I+PGF1dGhvcj5LYXJ2YW5lbiwgTS48L2F1dGhvcj48YXV0
aG9yPlBvbnRpa2lzLCBLLjwvYXV0aG9yPjxhdXRob3I+SmFuc3NvbiwgQi48L2F1dGhvcj48YXV0
aG9yPlBhcGFkb21pY2hlbGFraXMsIEUuPC9hdXRob3I+PGF1dGhvcj5BbnRvbmlhZG91LCBBLjwv
YXV0aG9yPjxhdXRob3I+R2lhbWFyZWxsb3UsIEguPC9hdXRob3I+PGF1dGhvcj5Bcm1hZ2FuaWRp
cywgQS48L2F1dGhvcj48YXV0aG9yPkNhcnMsIE8uPC9hdXRob3I+PGF1dGhvcj5GcmliZXJnLCBM
LiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFy
dG1lbnQgb2YgUGhhcm1hY2V1dGljYWwgQmlvc2NpZW5jZXMsIFVwcHNhbGEgVW5pdmVyc2l0eSwg
VXBwc2FsYSwgU3dlZGVuLiBhbWkubW9oYW1lZEBmYXJtYmlvLnV1LnNlPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+QXBwbGljYXRpb24gb2YgYSBsb2FkaW5nIGRvc2Ugb2YgY29saXN0aW4g
bWV0aGFuZXN1bGZvbmF0ZSBpbiBjcml0aWNhbGx5IGlsbCBwYXRpZW50czogcG9wdWxhdGlvbiBw
aGFybWFjb2tpbmV0aWNzLCBwcm90ZWluIGJpbmRpbmcsIGFuZCBwcmVkaWN0aW9uIG9mIGJhY3Rl
cmlhbCBraWxsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFudGltaWNyb2IgQWdlbnRzIENoZW1v
dGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFu
dGltaWNyb2IgQWdlbnRzIENoZW1vdGhlcjwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2Vz
PjQyNDEtOTwvcGFnZXM+PHZvbHVtZT41Njwvdm9sdW1lPjxudW1iZXI+ODwvbnVtYmVyPjxrZXl3
b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3
b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkFudGktQmFjdGVyaWFsIEFn
ZW50cy8qYWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlLypwaGFybWFjb2tpbmV0aWNzL3RoZXJh
cGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Db2xpc3Rpbi8qYWRtaW5pc3RyYXRpb24gJmFt
cDsgZG9zYWdlLypwaGFybWFjb2tpbmV0aWNzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5
d29yZD5Dcml0aWNhbCBJbGxuZXNzPC9rZXl3b3JkPjxrZXl3b3JkPkRvc2UtUmVzcG9uc2UgUmVs
YXRpb25zaGlwLCBEcnVnPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29y
ZD5HcmFtLU5lZ2F0aXZlIEJhY3RlcmlhbCBJbmZlY3Rpb25zLypkcnVnIHRoZXJhcHkvbWljcm9i
aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r
ZXl3b3JkPjxrZXl3b3JkPk1pY3JvYmlhbCBTZW5zaXRpdml0eSBUZXN0czwva2V5d29yZD48a2V5
d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9r
ZXl3b3JkPjxrZXl3b3JkPlByb3RlaW4gQmluZGluZzwva2V5d29yZD48a2V5d29yZD5Qc2V1ZG9t
b25hcyBhZXJ1Z2lub3NhLypkcnVnIGVmZmVjdHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+
PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48
L2RhdGVzPjxpc2JuPjEwOTgtNjU5NiAoRWxlY3Ryb25pYykmI3hEOzAwNjYtNDgwNCAoTGlua2lu
Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjI2MTUyODU8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJl
bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjI2MTUy
ODU8L3VybD48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wbWMvYXJ0aWNsZXMvUE1D
MzQyMTYyNi9wZGYvemFjNDI0MS5wZGY8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3Rv
bTI+UE1DMzQyMTYyNjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEyOC9B
QUMuMDY0MjYtMTE8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0
ZT48QXV0aG9yPkphY29iczwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4xNDc5PC9S
ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xNDc5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+
PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVwMGFnZTUwcGlleGR0MXhzMmRtejVyMnIyZXR4c2Qw
IiB0aW1lc3RhbXA9IjE0NTY2OTkzNTAiPjE0Nzk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5
cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0
aG9ycz48YXV0aG9yPkphY29icywgTS48L2F1dGhvcj48YXV0aG9yPkdyZWdvaXJlLCBOLjwvYXV0
aG9yPjxhdXRob3I+TWVnYXJiYW5lLCBCLjwvYXV0aG9yPjxhdXRob3I+R29iaW4sIFAuPC9hdXRo
b3I+PGF1dGhvcj5CYWxheW4sIEQuPC9hdXRob3I+PGF1dGhvcj5NYXJjaGFuZCwgUy48L2F1dGhv
cj48YXV0aG9yPk1pbW96LCBPLjwvYXV0aG9yPjxhdXRob3I+Q291ZXQsIFcuPC9hdXRob3I+PC9h
dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+SW5zZXJtIFUxMDcwLCBQb2l0aWVy
cywgRnJhbmNlIFVuaXZlcnNpdGUgZGUgUG9pdGllcnMsIFVGUiBNZWRlY2luZS1QaGFybWFjaWUs
IFBvaXRpZXJzLCBGcmFuY2UuJiN4RDtIb3NwaXRhbCBMYXJpYm9pc2llcmUsIFBhcmlzLCBGcmFu
Y2UuJiN4RDtJbnNlcm0gVTEwNzAsIFBvaXRpZXJzLCBGcmFuY2UgQ0hVIFBvaXRpZXJzLCBQb2l0
aWVycywgRnJhbmNlLiYjeEQ7SW5zZXJtIFUxMDcwLCBQb2l0aWVycywgRnJhbmNlIFVuaXZlcnNp
dGUgZGUgUG9pdGllcnMsIFVGUiBNZWRlY2luZS1QaGFybWFjaWUsIFBvaXRpZXJzLCBGcmFuY2Ug
Q0hVIFBvaXRpZXJzLCBQb2l0aWVycywgRnJhbmNlLiYjeEQ7SW5zZXJtIFUxMDcwLCBQb2l0aWVy
cywgRnJhbmNlIFVuaXZlcnNpdGUgZGUgUG9pdGllcnMsIFVGUiBNZWRlY2luZS1QaGFybWFjaWUs
IFBvaXRpZXJzLCBGcmFuY2UgQ0hVIFBvaXRpZXJzLCBQb2l0aWVycywgRnJhbmNlIHdpbGxpYW0u
Y291ZXRAdW5pdi1wb2l0aWVycy5mci48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Qb3B1
bGF0aW9uIFBoYXJtYWNva2luZXRpY3Mgb2YgQ29saXN0aW4gTWV0aGFuZXN1bGZvbmF0ZSBhbmQg
Q29saXN0aW4gaW4gQ3JpdGljYWxseSBJbGwgUGF0aWVudHMgd2l0aCBBY3V0ZSBSZW5hbCBGYWls
dXJlIFJlcXVpcmluZyBJbnRlcm1pdHRlbnQgSGVtb2RpYWx5c2lzPC90aXRsZT48c2Vjb25kYXJ5
LXRpdGxlPkFudGltaWNyb2IgQWdlbnRzIENoZW1vdGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0
bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFudGltaWNyb2IgQWdlbnRzIENoZW1vdGhlcjwv
ZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjE3ODgtOTM8L3BhZ2VzPjx2b2x1bWU+NjA8
L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48L2RhdGVz
Pjxpc2JuPjEwOTgtNjU5NiAoRWxlY3Ryb25pYykmI3hEOzAwNjYtNDgwNCAoTGlua2luZyk8L2lz
Ym4+PGFjY2Vzc2lvbi1udW0+MjY3Mjk0OTI8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQt
dXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjY3Mjk0OTI8L3Vy
bD48dXJsPmh0dHA6Ly9hYWMuYXNtLm9yZy9jb250ZW50LzYwLzMvMTc4ODwvdXJsPjwvcmVsYXRl
ZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEyOC9BQUMuMDE4Njgt
MTU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y
PlBsYWNob3VyYXM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNOdW0+MTUwNjwvUmVjTnVt
PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTUwNjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9Ijl6czVlcDBhZ2U1MHBpZXhkdDF4czJkbXo1cjJyMmV0eHNkMCIgdGlt
ZXN0YW1wPSIxNDU2NzAzOTExIj4xNTA2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h
bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+
PGF1dGhvcj5QbGFjaG91cmFzLCBELjwvYXV0aG9yPjxhdXRob3I+S2FydmFuZW4sIE0uPC9hdXRo
b3I+PGF1dGhvcj5GcmliZXJnLCBMLiBFLjwvYXV0aG9yPjxhdXRob3I+UGFwYWRvbWljaGVsYWtp
cywgRS48L2F1dGhvcj48YXV0aG9yPkFudG9uaWFkb3UsIEEuPC9hdXRob3I+PGF1dGhvcj5Uc2Fu
Z2FyaXMsIEkuPC9hdXRob3I+PGF1dGhvcj5LYXJhaXNrb3MsIEkuPC9hdXRob3I+PGF1dGhvcj5Q
b3VsYWtvdSwgRy48L2F1dGhvcj48YXV0aG9yPktvbnRvcGlkb3UsIEYuPC9hdXRob3I+PGF1dGhv
cj5Bcm1hZ2FuaWRpcywgQS48L2F1dGhvcj48YXV0aG9yPkNhcnMsIE8uPC9hdXRob3I+PGF1dGhv
cj5HaWFtYXJlbGxvdSwgSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt
YWRkcmVzcz40dGggRGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2luZSwgQXR0aWtvbiBVbml2
ZXJzaXR5IEdlbmVyYWwgSG9zcGl0YWwsIEhhaWRhcmkgMTI0NjIsIEdyZWVjZS4gZHBsYWNoQG1l
ZC51b2EuZ3I8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Qb3B1bGF0aW9uIHBoYXJtYWNv
a2luZXRpYyBhbmFseXNpcyBvZiBjb2xpc3RpbiBtZXRoYW5lc3VsZm9uYXRlIGFuZCBjb2xpc3Rp
biBhZnRlciBpbnRyYXZlbm91cyBhZG1pbmlzdHJhdGlvbiBpbiBjcml0aWNhbGx5IGlsbCBwYXRp
ZW50cyB3aXRoIGluZmVjdGlvbnMgY2F1c2VkIGJ5IGdyYW0tbmVnYXRpdmUgYmFjdGVyaWE8L3Rp
dGxlPjxzZWNvbmRhcnktdGl0bGU+QW50aW1pY3JvYiBBZ2VudHMgQ2hlbW90aGVyPC9zZWNvbmRh
cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW50aW1pY3JvYiBBZ2Vu
dHMgQ2hlbW90aGVyPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MzQzMC02PC9wYWdl
cz48dm9sdW1lPjUzPC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3Jk
PkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAg
YW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+Q2hyb21hdG9ncmFwaHksIExpcXVpZDwva2V5d29y
ZD48a2V5d29yZD5Db2xpc3Rpbi9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvKmFuYWxvZ3Mg
JmFtcDs8L2tleXdvcmQ+PGtleXdvcmQ+ZGVyaXZhdGl2ZXMvKnBoYXJtYWNva2luZXRpY3MvKnRo
ZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Dcml0aWNhbCBJbGxuZXNzPC9rZXl3b3Jk
PjxrZXl3b3JkPkRydWcgUmVzaXN0YW5jZSwgTXVsdGlwbGUsIEJhY3RlcmlhbC8qZHJ1ZyBlZmZl
Y3RzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5HcmFtLU5lZ2F0
aXZlIEJhY3RlcmlhLypkcnVnIGVmZmVjdHMvcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5H
cmFtLU5lZ2F0aXZlIEJhY3RlcmlhbCBJbmZlY3Rpb25zLypkcnVnIHRoZXJhcHk8L2tleXdvcmQ+
PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZnVzaW9ucywgSW50cmF2ZW5vdXM8
L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5
d29yZD48a2V5d29yZD5UYW5kZW0gTWFzcyBTcGVjdHJvbWV0cnk8L2tleXdvcmQ+PC9rZXl3b3Jk
cz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZzwvZGF0ZT48L3B1
Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgtNjU5NiAoRWxlY3Ryb25pYykmI3hEOzAwNjYtNDgw
NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk0MzM1NzA8L2FjY2Vzc2lvbi1udW0+
PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJt
ZWQvMTk0MzM1NzA8L3VybD48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wbWMvYXJ0
aWNsZXMvUE1DMjcxNTU5OS9wZGYvMTM2MS0wOC5wZGY8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy
bHM+PGN1c3RvbTI+UE1DMjcxNTU5OTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
MTAuMTEyOC9BQUMuMDEzNjEtMDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwv
Q2l0ZT48Q2l0ZT48QXV0aG9yPkthcmFpc2tvczwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl
Y051bT4xNDk3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xNDk3PC9yZWMtbnVtYmVyPjxm
b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVwMGFnZTUwcGlleGR0MXhzMmRt
ejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE0NTY2OTk0NjciPjE0OTc8L2tleT48L2ZvcmVpZ24t
a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy
aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkthcmFpc2tvcywgSS48L2F1dGhvcj48YXV0aG9yPkZy
aWJlcmcsIEwuIEUuPC9hdXRob3I+PGF1dGhvcj5Qb250aWtpcywgSy48L2F1dGhvcj48YXV0aG9y
PklvYW5uaWRpcywgSy48L2F1dGhvcj48YXV0aG9yPlRzYWdrYXJpLCBWLjwvYXV0aG9yPjxhdXRo
b3I+R2FsYW5pLCBMLjwvYXV0aG9yPjxhdXRob3I+S29zdGFrb3UsIEUuPC9hdXRob3I+PGF1dGhv
cj5CYXppYWthLCBGLjwvYXV0aG9yPjxhdXRob3I+UGFza2FsaXMsIEMuPC9hdXRob3I+PGF1dGhv
cj5Lb3V0c291a291LCBBLjwvYXV0aG9yPjxhdXRob3I+R2lhbWFyZWxsb3UsIEguPC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+NnRoIERlcGFydG1lbnQgb2Yg
SW50ZXJuYWwgTWVkaWNpbmUsIEh5Z2VpYSBHZW5lcmFsIEhvc3BpdGFsLCBBdGhlbnMsIEdyZWVj
ZSBpbGlhc2thcmFpc2tvc0BnbWFpbC5jb20uJiN4RDtEZXBhcnRtZW50IG9mIFBoYXJtYWNldXRp
Y2FsIEJpb3NjaWVuY2VzLCBVcHBzYWxhIFVuaXZlcnNpdHksIFN3ZWRlbi4mI3hEOzFzdCBEZXBh
cnRtZW50IG9mIFJlc3BpcmF0b3J5IERpc2Vhc2VzLUludGVuc2l2ZSBDYXJlIFVuaXQsIFNvdGly
aWEgSG9zcGl0YWwsIEdyZWVjZS4mI3hEO0NsaW5pY2FsIFBoYXJtYWNpc3QsIEh5Z2VpYSBHZW5l
cmFsIEhvc3BpdGFsLCBBdGhlbnMsIEdyZWVjZS4mI3hEOzZ0aCBEZXBhcnRtZW50IG9mIEludGVy
bmFsIE1lZGljaW5lLCBIeWdlaWEgR2VuZXJhbCBIb3NwaXRhbCwgQXRoZW5zLCBHcmVlY2UuJiN4
RDtJbnRlbnNpdmUgQ2FyZSBVbml0LCBIeWdlaWEgR2VuZXJhbCBIb3NwaXRhbCwgQXRoZW5zLCBH
cmVlY2UuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29saXN0aW4gUG9wdWxhdGlvbiBQ
aGFybWFjb2tpbmV0aWNzIGFmdGVyIEFwcGxpY2F0aW9uIG9mIGEgTG9hZGluZyBEb3NlIG9mIDkg
TVUgQ29saXN0aW4gTWV0aGFuZXN1bGZvbmF0ZSBpbiBDcml0aWNhbGx5IElsbCBQYXRpZW50czwv
dGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbnRpbWljcm9iIEFnZW50cyBDaGVtb3RoZXI8L3NlY29u
ZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbnRpbWljcm9iIEFn
ZW50cyBDaGVtb3RoZXI8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz43MjQwLTg8L3Bh
Z2VzPjx2b2x1bWU+NTk8L3ZvbHVtZT48bnVtYmVyPjEyPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIw
MTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48
aXNibj4xMDk4LTY1OTYgKEVsZWN0cm9uaWMpJiN4RDswMDY2LTQ4MDQgKExpbmtpbmcpPC9pc2Ju
PjxhY2Nlc3Npb24tbnVtPjI2MzY5OTc0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI2MzY5OTc0PC91cmw+
PHVybD5odHRwOi8vYWFjLmFzbS5vcmcvY29udGVudC81OS8xMi83MjQwLmxvbmc8L3VybD48L3Jl
bGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNDY0OTI1MzwvY3VzdG9tMj48ZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+MTAuMTEyOC9BQUMuMDA1NTQtMTU8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut
bnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPk1vaGFtZWQ8L0F1dGhvcj48WWVhcj4y
MDEyPC9ZZWFyPjxSZWNOdW0+MzA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjMwPC9yZWMt
bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVwMGFnZTUwcGll
eGR0MXhzMmRtejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE0NDAyNjQzODAiPjMwPC9rZXk+PC9m
b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl
Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Nb2hhbWVkLCBBLiBGLjwvYXV0aG9yPjxh
dXRob3I+S2FyYWlza29zLCBJLjwvYXV0aG9yPjxhdXRob3I+UGxhY2hvdXJhcywgRC48L2F1dGhv
cj48YXV0aG9yPkthcnZhbmVuLCBNLjwvYXV0aG9yPjxhdXRob3I+UG9udGlraXMsIEsuPC9hdXRo
b3I+PGF1dGhvcj5KYW5zc29uLCBCLjwvYXV0aG9yPjxhdXRob3I+UGFwYWRvbWljaGVsYWtpcywg
RS48L2F1dGhvcj48YXV0aG9yPkFudG9uaWFkb3UsIEEuPC9hdXRob3I+PGF1dGhvcj5HaWFtYXJl
bGxvdSwgSC48L2F1dGhvcj48YXV0aG9yPkFybWFnYW5pZGlzLCBBLjwvYXV0aG9yPjxhdXRob3I+
Q2FycywgTy48L2F1dGhvcj48YXV0aG9yPkZyaWJlcmcsIEwuIEUuPC9hdXRob3I+PC9hdXRob3Jz
PjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQaGFybWFjZXV0aWNh
bCBCaW9zY2llbmNlcywgVXBwc2FsYSBVbml2ZXJzaXR5LCBVcHBzYWxhLCBTd2VkZW4uIGFtaS5t
b2hhbWVkQGZhcm1iaW8udXUuc2U8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BcHBsaWNh
dGlvbiBvZiBhIGxvYWRpbmcgZG9zZSBvZiBjb2xpc3RpbiBtZXRoYW5lc3VsZm9uYXRlIGluIGNy
aXRpY2FsbHkgaWxsIHBhdGllbnRzOiBwb3B1bGF0aW9uIHBoYXJtYWNva2luZXRpY3MsIHByb3Rl
aW4gYmluZGluZywgYW5kIHByZWRpY3Rpb24gb2YgYmFjdGVyaWFsIGtpbGw8L3RpdGxlPjxzZWNv
bmRhcnktdGl0bGU+QW50aW1pY3JvYiBBZ2VudHMgQ2hlbW90aGVyPC9zZWNvbmRhcnktdGl0bGU+
PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW50aW1pY3JvYiBBZ2VudHMgQ2hlbW90
aGVyPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NDI0MS05PC9wYWdlcz48dm9sdW1l
PjU2PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9r
ZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8
L2tleXdvcmQ+PGtleXdvcmQ+QW50aS1CYWN0ZXJpYWwgQWdlbnRzLyphZG1pbmlzdHJhdGlvbiAm
YW1wOyBkb3NhZ2UvKnBoYXJtYWNva2luZXRpY3MvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxr
ZXl3b3JkPkNvbGlzdGluLyphZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvKnBoYXJtYWNva2lu
ZXRpY3MvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkNyaXRpY2FsIElsbG5lc3M8
L2tleXdvcmQ+PGtleXdvcmQ+RG9zZS1SZXNwb25zZSBSZWxhdGlvbnNoaXAsIERydWc8L2tleXdv
cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdyYW0tTmVnYXRpdmUgQmFjdGVy
aWFsIEluZmVjdGlvbnMvKmRydWcgdGhlcmFweS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdv
cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWljcm9i
aWFsIFNlbnNpdGl2aXR5IFRlc3RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3
b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvdGVp
biBCaW5kaW5nPC9rZXl3b3JkPjxrZXl3b3JkPlBzZXVkb21vbmFzIGFlcnVnaW5vc2EvKmRydWcg
ZWZmZWN0czwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWIt
ZGF0ZXM+PGRhdGU+QXVnPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5OC02NTk2
IChFbGVjdHJvbmljKSYjeEQ7MDA2Ni00ODA0IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51
bT4yMjYxNTI4NTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov
L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMjYxNTI4NTwvdXJsPjx1cmw+aHR0cDovL3d3
dy5uY2JpLm5sbS5uaWguZ292L3BtYy9hcnRpY2xlcy9QTUMzNDIxNjI2L3BkZi96YWM0MjQxLnBk
ZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMzNDIxNjI2PC9jdXN0b20y
PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTI4L0FBQy4wNjQyNi0xMTwvZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA 1,2,6-15Polymyxin B offers pharmacokinetic advantages over colistin due to its administration directly as active drug. Colistimethate, the prodrug form of colistin, is eliminated primarily by glomerular filtration with a variable proportion of the administered dose converted to active drug via hydrolysis of five pro-drug functional groups. Both formed colistin and polymyxin B undergo extensive reabsorption (~95%) in the renal tubules and are then eliminated by non-renal mechanisms. The differential elimination of colistimethate and formed colistin along with the variable hydrolysis of the prodrug to active drug are the cause of significant interpatient variability in colistin pharmacokinetics.Table 2: Polymyxin population pharmacokinetic parameters in critically ill patientsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXRpb248L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXRpb248L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 6,8,12ColistinPolymyxin B sulfateAbsorption ----Half-life11 h12 hVolume of DistributionCMS: 29 LColistin: 28 L29 LProtein Binding~65%~60%Metabolism CMS: Non-hepatic hydrolysis to active colistinColistin: Unknown, non-hepaticUnknown, non-hepaticEliminationCMS: RenalColistin: Non-renalNon-renalAbbreviations: CMS, colistimethate sodium; h, hours; L, litersPharmacokinetic values for colistin reflect formed colistin, unless otherwise noted. PharmacodynamicsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EdWRoYW5pPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EdWRoYW5pPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE.DATA 16-23The pharmacodynamic index most predictive of bacterial killing in animal models is the ratio between the area under the free drug concentration time curve and the bacterial minimum inhibitory concentration (fAUC/MIC). The magnitude of this parameter associated with varying degrees of bacterial kill in neutropenic mouse infection models are presented below in Table 3. While colistin was used in this study, it is assumed that the pharmacodynamics can be extrapolated to polymyxin B. It is important to note that animals in this study were treated with colistin monotherapy, and therefore the pharmacodynamic targets elucidated reflect those required with monotherapy. Based on the results of in vitro combination time kill studies, it is likely that these targets would be lowered with the use of synergistic combination therapy as is done in clinical practice. Additionally, it should be emphasized that the inhibition of growth and bacterial killing only occurred for one of the three A. baumannii isolates in the lung infection model further highlighting the need for combination therapy. Many clinically important gram-negative bacteria express significant heteroresistance to polymyxin B and colistin within populations leading resistance amplification with monotherapy. Loading doses should be used to rapidly attain therapeutic concentrations, especially with colistin given the time-dependence of conversion from colistimethate for activity.The pharmacodynamic target extrapolated from these data and use for modeling of doses is the average steady state concentration during the dosing interval (Cave,ss). Using the protein bindinding of colistin and polymyxin B, the Cave,ss values corresponding to the fAUC/MIC values below can be computed. A total drug average steady-state concentration of 1-2 mcg/mL should be sufficient for bactericidal activity for infections with susceptible organisms (MIC ≤ 1) at accessible sites (i.e. thigh infection model). Conversely, total drug average steady-state concentrations of 2-4 mcg/mL would be necessary to treat infections due to pathogens with elevated polymyxin MICs (> 1) or located at difficult to penetrate sites (lung infection model). This target is generally simplified as 2-3 mcg/mL. The therapeutic index of the polymyxins is very narrow with studies finding a higher incidence of nephrotoxicity with concentrations greater than 2.5 mcg/mL. No validated therapeutic drug monitoring methods are clinically available.Table 3: Colistin fAUC/MIC [mg*h/L] values associated with varying degrees of bacterial killing in two murine infection models BacteriaStasis1 log10 kill2 log10 killThigh Infection ModelP. aeruginosa6.0 ; 7.5; 8.76.6; 10.0; 10.97.4; 13.5; 13.7A. baumanii1.4; 3.9; 9.33.5; 6.0; 13.97.4; 9.0; 17.6Lung Infection ModelP. aeruginosa15.2; 34.1; 38.643.3; 44.8; 57.951.8; NR; 105.0A. baumaniiNR, 11.6, NRNR, 20.8; NRNR; 36.8; NRAbbreviation: NR, value not reached, indicating that the tested strain did not reach the indicated level of kill for any value of fAUC/MIC testedValues represent the median fAUC/MIC associated with killing for each strain obtained from 10,000 run Monte Carlo simulationsAdverse ReactionsPEVuZE5vdGU+PENpdGU+PFJlY051bT41ODQ2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBm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 EN.CITE PEVuZE5vdGU+PENpdGU+PFJlY051bT41ODQ2PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBm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 EN.CITE.DATA 1-3,24-27Black Box Warning: Polymyxin B has a black box warning for neurotoxicity and nephrotoxicity. Renal function monitoring is recommended during therapy with a recommendation to reduce the dose of polymyxin B in patients with renal impairment. It is important to note that reducing the dose of polymyxin B in renal impairment IS NO LONGER RECOMMENDED due to an increased understanding of the pharmacokinetics of this drug. The warning also states that the polymyxin B neurotoxicity can result in respiratory paralysis from neuromuscular blockade, especially when administered after anesthesia and/or muscle relaxants. Safety of polymyxin B in human pregnancy has not been established.The primary toxicity of the polymyxins is nephrotoxicity. The frequency of nephrotoxicity associated with these agents varies from 20% up to 75% depending in the literature. Retrospective data have indicated a trend toward lower nephrotoxicity with polymyxin B relative to colistin. A 2017 meta-analysis of these data found a two-fold increased risk of nephrotoxicity (aHR 2.17, 95% CI 1.43-3.27) with colistin-treatment relative to polymyxin B. While there is a signal of lower nephrotoxicity with polymyxin B, it should be noted that the studies supporting this are all retrospective in nature with many limitations to the generalizability of their results. Polymyxin B and colistin are also associated with neurotoxicities, primarily mild and reversible paresthesias (especially perioral); however, more serious events, including neuromuscular blockade leading to apnea and seizures, have been reported. The incidence of these toxicities is difficult to ascertain due to sporadic reporting. Drug Interactions ADDIN EN.CITE <EndNote><Cite><Author>Ordooei Javan</Author><Year>2015</Year><RecNum>9</RecNum><DisplayText><style face="superscript">27</style></DisplayText><record><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="9zs5ep0age50piexdt1xs2dmz5r2r2etxsd0" timestamp="1440263716">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ordooei Javan, A.</author><author>Shokouhi, S.</author><author>Sahraei, Z.</author></authors></contributors><auth-address>Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Niyayesh Cross Road, Valiasr Street, Tehran, Iran.</auth-address><titles><title>A review on colistin nephrotoxicity</title><secondary-title>Eur J Clin Pharmacol</secondary-title></titles><periodical><full-title>Eur J Clin Pharmacol</full-title></periodical><pages>801-10</pages><volume>71</volume><number>7</number><dates><year>2015</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1432-1041 (Electronic)
0031-6970 (Linking)</isbn><accession-num>26008213</accession-num><urls><related-urls><url> B is not a substrate of any important hepatic drug metabolizing enzymes or transporters and is unlikely to be associated with any drug-drug interactions via this mechanism. Polymyxin B is nephrotoxic and coadministration with other known nephrotoxins should be avoided. Polymyxin B should not be coadministered with aminoglycosides due to an additive risk for nephrotoxicity and neurotoxicity. Concurrently administered nephrotoxins associated with polymyxin B nephrotoxicity in clinical studies include non-steroidal anti-inflammatory drugs (NSAIDs), intravenous contrast, vancomycin, rifampin, calcineurin inhibitors, and loop diuretics. Co-administration with non-depolarizing neuromuscular blockers may lead to additive toxicity resulting in prolonged or enhanced neuromuscular blockade.Medication Safety and AdministrationBoth polymyxin B and colistimethate sodium are available as powder for reconstitution. Drug potency is listed in various units worldwide. The dosages listed below in Table 5 are equivalent expressions of drug potency and each represent the amount of drug activity contained in one vial. Polymyxin B has traditionally been diluted in 500 mL of D5W and administered via continuous infusion; however, recent stability data demonstrated stability for 24 hours at room temperature at concentrations up to 2 mg/mL and in various diluents including NS, D5, 0.5NS/D5, 0.25NS/D5. The authors recommend infusing concentrated solutions through central access to limit infusion reactions. Recommended diluents, diluent volumes, and rates of infusion for the polymyxins are presented in Table 6. An overview of information related to medication safety with polymyxin B is presented in Table 7.Table 5: Equivalent expressions of potencyPolymyxin BColistimethate Sodium50 mg360 mg500,000 IU (0.5 MIU)4,500,000 IU (4.5 MIU)150 mg CBAAbbreviations: mg = milligrams, IU = international units, MIU = million international Italicized text indicates units in MiChart, CBA = colistin base activityTable 6: Dilution and administration ADDIN EN.CITE <EndNote><Cite><Author>Lim</Author><Year>2016</Year><RecNum>2544</RecNum><DisplayText><style face="superscript">28</style></DisplayText><record><rec-number>2544</rec-number><foreign-keys><key app="EN" db-id="9zs5ep0age50piexdt1xs2dmz5r2r2etxsd0" timestamp="1484755083">2544</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lim, T. P.</author><author>Hee, D. K.</author><author>Lee, W.</author><author>Teo, J. Q.</author><author>Cai, Y.</author><author>Chia, S. Y.</author><author>Leaw, J. Y.</author><author>Lee, S. J.</author><author>Lee, L. S.</author><author>Kwa, A. L.</author></authors></contributors><titles><title>Physicochemical Stability Study of Polymyxin B in Various Infusion Solutions for Administration to Critically Ill Patients</title><secondary-title>Ann Pharmacother</secondary-title></titles><periodical><full-title>Ann Pharmacother</full-title><abbr-1>The Annals of pharmacotherapy</abbr-1></periodical><pages>790-2</pages><volume>50</volume><number>9</number><dates><year>2016</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1542-6270 (Electronic)
1060-0280 (Linking)</isbn><accession-num>27199496</accession-num><urls><related-urls><url> BColistimethate SodiumFluidNS, D5WNS, D5WVolume250 mLa100 mLRate1-2 hours1-2 hoursTable 7: Medication safety ADDIN EN.CITE <EndNote><Cite><RecNum>5846</RecNum><DisplayText><style face="superscript">1</style></DisplayText><record><rec-number>5846</rec-number><foreign-keys><key app="EN" db-id="9zs5ep0age50piexdt1xs2dmz5r2r2etxsd0" timestamp="1512161919">5846</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors></contributors><titles><title>Polymyxin B Sulfate [package insert]. Bedford Laboratories, Bedford, OH; June 2011.</title></titles><dates></dates><urls></urls></record></Cite></EndNote>1REMS (Risk Evaluation Mitigation Strategy) NonePregnancy CategoryNoneBlack Box WarningNephrotoxicity and Neurotoxicity. See section: Adverse ReactionsISMP Medication Safety ConcernsNo ISMP documented concerns with polymyxin B. Dosing errors have been reported for intravenous colistin due to multiple potential units of potency (see Table 5). Additionally, an FDA Alert exists for nebulized colistimethate due to the potential formation of a breakdown product toxic to lung tissue if stored in an aqueous form for more than 24 hours.Hazardous Risk AssessmentNot hazardousExtravasation PotentialLowLatexNoDo Not CrushParenteral onlyElectronic Health Record Safety AssessmentNoneMiscellaneous Safety ConcernsNo bolus injections ContraindicationsHistory of hypersensitivity reactions to polymyxinsInfections due to with intrinsic resistance to polymyxinsDosage and AdministrationbmZlY3Rpb3VzIERpc2Vhc2VzLCBSYWJpbiBNZWRpY2FsIENlbnRlciwgQmVpbGluc29uIEhvc3Bp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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kcmk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA bmZlY3Rpb3VzIERpc2Vhc2VzLCBSYWJpbiBNZWRpY2FsIENlbnRlciwgQmVpbGluc29uIEhvc3Bp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ADDIN EN.CITE.DATA 6-15,29-35 Intravenous and Inhaled TherapyThe optimal dosing of polymyxin B and colistin is an area of significant clinical equipoise currently. The dosing recommendations listed here are derived from pharmacokinetic and clinical outcomes studies as well as simulations assessing attainment of the pharmacodynamic efficacy targets listed above. The FDA-labeled dosing for colistin is by body weight and renal function whereas the European Medicines Agency (EMA) uses fixed doses adjusted for renal function based on newer pharmacokinetic/pharmacodynamic data. Table 8: Dosing of Systemic and Inhaled Polymyxin Agents in Adult PatientsPolymyxin AgentLoading DoseCrCl > 50 mL/minCrCl 50-30 mL/minCrCl 29-10 mL/minCrCl <10 mL/min, HDCRRTINTRAVENOUS THERAPYPolymyxin Ba,b,c2 mg/kg x1(MAX 200 mg)1.25 mg/kg q12h (MAX 200 mg/day)Colistinb,c,d5 mg/kg x1(MAX 300 mg CBA)2.5 mg CBA/kg q12h1.75 mg CBA/kg q12h2.5 mg CBA/kg q24h1.5 mg CBA/kg q24h2.5 mg CBA/kg q12hINHALED THERAPYColistin150 mg CBA nebulized q12hAbbreviations: CrCL, creatinine clearance; HD, hemodialysis; CRRT, continuous renal replacement therapy; CBA, colistin base activity; adjBW, adjusted body weight; TBW, total body weight; IBW, ideal body weighta No dosing adjustment is necessary for polymyxin B for renal or hepatic dysfunctionb adjBW should be used to calculate doses for patients with TBW > 125% IBW c Maintenance dosing should be initiated 12 hours after the loading doses are administeredd The maximum total daily maintenance dose of colistin should not exceed 300 mg CBA/daySpecial PopulationsRenal Impairment: No dosage adjustment is required for polymyxin B. See Table 8 for renal adjustments for colistinHepatic Impairment: No dosage adjustment necessary for either polymyxin B or colistinElderly: No dosage adjustment necessary; however, caution should be used as this patient population may be more sensitive to the toxicities of the polymyxins. Pediatrics: Limited data exist for the use of either systemic polymyxin B or colistin in pediatric patient populations. Recommended doses of both agents are listed in table 9 belowTable 9: Dosing of Systemic and Inhaled Poylymxin Agents in Pediatric PatientsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaWRkaXF1aTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaWRkaXF1aTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA 36-40Polymyxin AgentInfantsChildren/AdolescentsINTRAVENOUS THERAPYPolymyxin Ba,b2.5 mg/kg/day in 2 divided doses2.5 mg/kg/day in 2-4 divided doses(MAX 200 mg/day)Colistinb,c,d5 mg/kg/day in 2-4 divided doses5 mg/kg/day in 2-3 divided doses(MAX 300 mg CBA/day)INHALED THERAPYColistinNot recommended75-150 mg CBA nebulized q12hAbbreviations: CBA, colistin base activitya No dosing adjustment is necessary for polymyxin B for renal or hepatic dysfunctionb Loading doses are not routinely used in pediatric patientsd Higher doses up to 8 mg CBA/kg/day have been used in pediatric children/adolescents with cystic fibrosis. Dosing should be determined in consultation with infectious diseases or pulmonary specialists Pharmacoeconomic ConsiderationsThe economic impact of polymyxin B to Michigan Medicine is outlined in Table 10.Table 10: Availability and Cost UMHS Cost/Dosage FormUsual DoseUMHS Loading Dose Cost (70 kg)UMHS Maintenance Dose Cost per day (70 kg)Polymyxin B sulfate injection (50 mg vial)$5.812 mg/kg x 1 then 1.25 mg/kg Q12h$16.27$20.34Colistimethate sodium injection (150 mg CBA vial)$10.585 mg/kg x 1 then 2.5 mg/kg Q12h$24.69$24.69 RecommendationsBased on the above presented data, we recommend the addition of polymyxin B to the Michigan Medicine formulary as a Tier 1 restricted antimicrobial agent, requiring Antimicrobial Stewardship Team approval prior to initiation. We recommend that polymyxin B replace colistin on formulary as the preferred polymyxin B for most systemic infections as outlined in detail below. Colistin will remain on formulary for use in urinary source infections, systemic treatment of pediatric patients with cystic fibrosis, and inhaled therapy. Additionally, infectious diseases consultation is preferred when considering the use of polymyxins. The rationale for this change is as follows: AGENT SELECTION: Polymyxin B is the preferred systemic polymyxin for extraurinary infectionsRationale: Colistimethate sodium is associated with significant interpatient variability in pharmacokinetic studies.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXRpb248L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS
ZWNOdW0+MjU0NTwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi
PjcsODwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjI1NDU8L3JlYy1u
dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI5enM1ZXAwYWdlNTBwaWV4
ZHQxeHMyZG16NXIycjJldHhzZDAiIHRpbWVzdGFtcD0iMTQ4NTM5MjMxNSI+MjU0NTwva2V5Pjwv
Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw
ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TmF0aW9uLCBSLiBMLjwvYXV0aG9yPjxh
dXRob3I+R2Fyb256aWssIFMuIE0uPC9hdXRob3I+PGF1dGhvcj5UaGFtbGlraXRrdWwsIFYuPC9h
dXRob3I+PGF1dGhvcj5HaWFtYXJlbGxvcy1Cb3VyYm91bGlzLCBFLiBKLjwvYXV0aG9yPjxhdXRo
b3I+Rm9ycmVzdCwgQS48L2F1dGhvcj48YXV0aG9yPlBhdGVyc29uLCBELiBMLjwvYXV0aG9yPjxh
dXRob3I+TGksIEouPC9hdXRob3I+PGF1dGhvcj5TaWx2ZWlyYSwgRi4gUC48L2F1dGhvcj48L2F1
dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EcnVnIERlbGl2ZXJ5LCBEaXNwb3Np
dGlvbiBhbmQgRHluYW1pY3MsIE1vbmFzaCBJbnN0aXR1dGUgb2YgUGhhcm1hY2V1dGljYWwgU2Np
ZW5jZXMsIE1vbmFzaCBVbml2ZXJzaXR5LCBNZWxib3VybmUsIEF1c3RyYWxpYSByb2dlci5uYXRp
b25AbW9uYXNoLmVkdS4mI3hEO1NjaG9vbCBvZiBQaGFybWFjeSBhbmQgUGhhcm1hY2V1dGljYWwg
U2NpZW5jZXMsIFVuaXZlcnNpdHkgYXQgQnVmZmFsbywgU1VOWSwgQnVmZmFsbywgTlkuJiN4RDtE
aXZpc2lvbiBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzIGFuZCBUcm9waWNhbCBNZWRpY2luZSwgRmFj
dWx0eSBvZiBNZWRpY2luZSBTaXJpcmFqIEhvc3BpdGFsLCBNYWhpZG9sIFVuaXZlcnNpdHksIEJh
bmdrb2ssIFRoYWlsYW5kLiYjeEQ7NCBEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBV
bml2ZXJzaXR5IG9mIEF0aGVucywgTWVkaWNhbCBTY2hvb2wsIEdyZWVjZS4mI3hEO1RoZSBVbml2
ZXJzaXR5IG9mIFF1ZWVuc2xhbmQgQ2VudGVyIGZvciBDbGluaWNhbCBSZXNlYXJjaCwgUm95YWwg
QnJpc2JhbmUgYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRhbCwgQnJpc2JhbmUsIEF1c3RyYWxpYS4m
I3hEO0RydWcgRGVsaXZlcnksIERpc3Bvc2l0aW9uIGFuZCBEeW5hbWljcywgTW9uYXNoIEluc3Rp
dHV0ZSBvZiBQaGFybWFjZXV0aWNhbCBTY2llbmNlcywgTW9uYXNoIFVuaXZlcnNpdHksIE1lbGJv
dXJuZSwgQXVzdHJhbGlhLiYjeEQ7RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcywgVW5p
dmVyc2l0eSBvZiBQaXR0c2J1cmdoIE1lZGljYWwgQ2VudGVyLCBQaXR0c2J1cmdoLCBQQS48L2F1
dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Eb3NpbmcgZ3VpZGFuY2UgZm9yIGludHJhdmVub3Vz
IGNvbGlzdGluIGluIGNyaXRpY2FsbHktaWxsIHBhdGllbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRp
dGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs
PjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PGtl
eXdvcmRzPjxrZXl3b3JkPkludHJhdmVub3VzIGNvbGlzdGluPC9rZXl3b3JkPjxrZXl3b3JkPmNy
aXRpY2FsbHktaWxsIHBhdGllbnRzPC9rZXl3b3JkPjxrZXl3b3JkPmRvc2luZyBndWlkYW5jZTwv
a2V5d29yZD48a2V5d29yZD5pbmZsdWVuY2Ugb2YgcmVuYWwgaW1wYWlybWVudCBhbmQgcmVuYWwg
cmVwbGFjZW1lbnQgbW9kYWxpdGllczwva2V5d29yZD48a2V5d29yZD5wb3B1bGF0aW9uIHBoYXJt
YWNva2luZXRpY3M8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48
cHViLWRhdGVzPjxkYXRlPkRlYyAyMzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1
MzctNjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vz
c2lvbi1udW0+MjgwMTE2MTQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs
Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjgwMTE2MTQ8L3VybD48dXJsPmh0
dHBzOi8vYWNhZGVtaWMub3VwLmNvbS9jaWQvYXJ0aWNsZS1hYnN0cmFjdC9kb2kvMTAuMTA5My9j
aWQvY2l3ODM5LzI3MzY3NTgvRG9zaW5nLWd1aWRhbmNlLWZvci1pbnRyYXZlbm91cy1jb2xpc3Rp
bi1pbj9yZWRpcmVjdGVkRnJvbT1mdWxsdGV4dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48
ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9jaWQvY2l3ODM5PC9lbGVjdHJvbmljLXJl
c291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HYXJvbnppazwvQXV0aG9y
PjxZZWFyPjIwMTE8L1llYXI+PFJlY051bT4yODwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+
Mjg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI5enM1ZXAw
YWdlNTBwaWV4ZHQxeHMyZG16NXIycjJldHhzZDAiIHRpbWVzdGFtcD0iMTQ0MDI2NDMyOSI+Mjg8
L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv
cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdhcm9uemlrLCBTLiBNLjwv
YXV0aG9yPjxhdXRob3I+TGksIEouPC9hdXRob3I+PGF1dGhvcj5UaGFtbGlraXRrdWwsIFYuPC9h
dXRob3I+PGF1dGhvcj5QYXRlcnNvbiwgRC4gTC48L2F1dGhvcj48YXV0aG9yPlNob2hhbSwgUy48
L2F1dGhvcj48YXV0aG9yPkphY29iLCBKLjwvYXV0aG9yPjxhdXRob3I+U2lsdmVpcmEsIEYuIFAu
PC9hdXRob3I+PGF1dGhvcj5Gb3JyZXN0LCBBLjwvYXV0aG9yPjxhdXRob3I+TmF0aW9uLCBSLiBM
LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNjaG9vbCBv
ZiBQaGFybWFjeSBhbmQgUGhhcm1hY2V1dGljYWwgU2NpZW5jZXMsIFVuaXZlcnNpdHkgYXQgQnVm
ZmFsbywgU1VOWSwgQnVmZmFsbywgTmV3IFlvcmssIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVz
Pjx0aXRsZT5Qb3B1bGF0aW9uIHBoYXJtYWNva2luZXRpY3Mgb2YgY29saXN0aW4gbWV0aGFuZXN1
bGZvbmF0ZSBhbmQgZm9ybWVkIGNvbGlzdGluIGluIGNyaXRpY2FsbHkgaWxsIHBhdGllbnRzIGZy
b20gYSBtdWx0aWNlbnRlciBzdHVkeSBwcm92aWRlIGRvc2luZyBzdWdnZXN0aW9ucyBmb3IgdmFy
aW91cyBjYXRlZ29yaWVzIG9mIHBhdGllbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFudGlt
aWNyb2IgQWdlbnRzIENoZW1vdGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp
Y2FsPjxmdWxsLXRpdGxlPkFudGltaWNyb2IgQWdlbnRzIENoZW1vdGhlcjwvZnVsbC10aXRsZT48
L3BlcmlvZGljYWw+PHBhZ2VzPjMyODQtOTQ8L3BhZ2VzPjx2b2x1bWU+NTU8L3ZvbHVtZT48bnVt
YmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+
QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29y
ZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvYmxvb2QvKnBoYXJtYWNva2luZXRpY3M8L2tleXdvcmQ+
PGtleXdvcmQ+Q29saXN0aW4vKmFuYWxvZ3MgJmFtcDsgZGVyaXZhdGl2ZXMvYmxvb2QvKnBoYXJt
YWNva2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+KkNyaXRpY2FsIElsbG5lc3M8L2tleXdvcmQ+
PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y
ZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPllv
dW5nIEFkdWx0PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PHB1
Yi1kYXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk4LTY1
OTYgKEVsZWN0cm9uaWMpJiN4RDswMDY2LTQ4MDQgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24t
bnVtPjIxNTU1NzYzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw
Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIxNTU1NzYzPC91cmw+PHVybD5odHRwOi8v
d3d3Lm5jYmkubmxtLm5paC5nb3YvcG1jL2FydGljbGVzL1BNQzMxMjI0NDAvcGRmL3phYzMyODQu
cGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzMxMjI0NDA8L2N1c3Rv
bTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgvQUFDLjAxNzMzLTEwPC9lbGVjdHJv
bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXRpb248L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 7,8 This is due primarily to differences in renal elimination of the inactive colistimethate prodrug as well as variable conversion to active colistin in vivo. Polymyxin B demonstrates more consistent pharmacokinetics and has been associated with either similar or lower rates of nephrotoxicity in retrospective clinical outcomes studies.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYXJkYWthczwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYXJkYWthczwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+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ADDIN EN.CITE.DATA 25 Colistimethate use is restricted to urinary source infections, pediatric patients with cystic fibrosis, and inhaled therapyRationale (urinary source): Polymyxin B undergoes extensive renal tubular reabsorption and is eliminated primarily by poorly characterized non-renal mechanisms leading to negligible penetration of drug to the bladder and lower renal structures.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kcmk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kcmk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA 6 Colistin undergoes extensive renal reabsorption in a manner analogous to polymyxin B; however, the prodrug colistimethate is eliminated renally and then hydrolyzed to active colistin within the lower urinary tract.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYXJvbnppazwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYXJvbnppazwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE.DATA 7,8 These differences in drug distribution affect penetration to the site of infection and indicate colistimethate for urinary sources.Rationale (pediatric cystic fibrosis): Colistimethate has been the only polymyxin agent studied in adult or pediatric patients with cystic fibrosis.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA 36,37 Although this patient population may be at increased risk for augmented renal clearance of the inactive colistimethate prodrug with resulting subtherapeutic colistin exposure, there are no pharmacokinetic data in pediatric patient populations with polymyxin B to guide dosing decisions. Additionally, patients with cystic fibrosis may also anecdotally be more sensitive to the neurotoxicities of polymyxin B than other patient populations. Selection of the optimal agent should balance the risk of colistin underexposure with the ability of the patient to tolerate systemic polymyxin B therapy and should be made in consultation with a pulmonologist and/or infectious diseases provider. Recommended criteria and exclusions for use are as follows: CRITERIA FOR USE: Systemic Therapy with Polymyxin B or ColistinTreatment of infections due to Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter spp, Escherichia coli, Klebsiella spp, or Citrobacter spp resistant or intolerant to all beta-lactams, aminoglycosides, and fluoroquinolones. Cystic fibrosis patients with minimal clinical response to standard therapy or cultures demonstrating multi-drug resistant gram-negative isolates, as defined above. Treatment with systemic polymyxins (IV polymyxin B or IV colistin) must be in combination with one or more additional antibiotics with gram-negative activity for synergistic activity and to prevent treatment emergent resistance.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaWdhdHRvPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaWdhdHRvPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA 38,39Inhaled Therapy with ColistinPatients with cystic fibrosis or bronchiectasis receiving inhaled polymyxins as continuation of home therapyPatients with cystic fibrosis or bronchiectasis who meet the clinical or microbiological criteria listed above for initiation of polymyxin therapyFor the adjunctive treatment of pneumonia, provided ALL the following criteria are metPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYWxpbDwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYWxpbDwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl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ADDIN EN.CITE.DATA 40Isolated pathogen is susceptible ONLY to polymyxins or aminoglycosidesInhaled therapy is used in addition to systemic therapy with a polymyxin or aminoglycoside in combination with another gram-negative antibiotic (usually a beta-lactam)EXCLUSIONS FOR USE:Systemic Therapy with Polymyxin B or ColistinThe isolated pathogen is intrinsically resistant to polymyxin antibiotics (see list below).3Burkholderia cepaciaMorganella morganiiProteus sppProvidencia sppSerratia marcesensThe isolated pathogen remains susceptible to one or more aminoglycoside antibiotics. Rationale: Polymyxins are reserved as last line agents for combination salvage therapy and should not be used when alternatives are available. Aminoglycosides are effective in combination with beta-lactams against multi-drug resistant gram-negative infections and are associated with lower rates of nephrotoxicity than polymyxins (9-27% v 20-75%, respectively).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJ6YTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJ6YTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl
Y051bT4xNDMzPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+
MzQsNDEtNDc8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNDMzPC9y
ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVwMGFnZTUw
cGlleGR0MXhzMmRtejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE0NTY2OTY1NjQiPjE0MzM8L2tl
eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm
LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJhcnphLCBNLjwvYXV0aG9yPjxh
dXRob3I+SW9hbm5pZGlzLCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+Q2FwcGVsbGVyaSwgSi4gQy48
L2F1dGhvcj48YXV0aG9yPkxhdSwgSi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+
PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBHZW9ncmFwaGljIE1lZGljaW5lIGFuZCBJbmZlY3Rp
b3VzIERpc2Vhc2VzLCBOZXcgRW5nbGFuZCBNZWRpY2FsIENlbnRlciBIb3NwaXRhbHMsIFR1ZnRz
IFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBCb3N0b24sIE1BIDAyMTExLCBVU0EuPC9h
dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+U2luZ2xlIG9yIG11bHRpcGxlIGRhaWx5IGRvc2Vz
IG9mIGFtaW5vZ2x5Y29zaWRlczogYSBtZXRhLWFuYWx5c2lzPC90aXRsZT48c2Vjb25kYXJ5LXRp
dGxlPkJNSjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkJNSjwvZnVsbC10aXRsZT48YWJici0xPkJtajwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+
MzM4LTQ1PC9wYWdlcz48dm9sdW1lPjMxMjwvdm9sdW1lPjxudW1iZXI+NzAyNzwvbnVtYmVyPjxr
ZXl3b3Jkcz48a2V5d29yZD5BbWlub2dseWNvc2lkZXM8L2tleXdvcmQ+PGtleXdvcmQ+QW50aS1C
YWN0ZXJpYWwgQWdlbnRzLyphZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvYWR2ZXJzZSBlZmZl
Y3RzPC9rZXl3b3JkPjxrZXl3b3JkPkJhY3RlcmlhbCBJbmZlY3Rpb25zLypkcnVnIHRoZXJhcHk8
L2tleXdvcmQ+PGtleXdvcmQ+RHJ1ZyBBZG1pbmlzdHJhdGlvbiBTY2hlZHVsZTwva2V5d29yZD48
a2V5d29yZD5FYXIgRGlzZWFzZXMvY2hlbWljYWxseSBpbmR1Y2VkPC9rZXl3b3JkPjxrZXl3b3Jk
Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD5LaWRuZXkgRGlzZWFzZXMvY2hlbWljYWxseSBpbmR1
Y2VkPC9rZXl3b3JkPjxrZXl3b3JkPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbHMgYXMgVG9w
aWM8L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlNlbnNp
dGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29t
ZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFyPjxwdWItZGF0ZXM+
PGRhdGU+RmViIDEwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDk1OS04MTM4IChQ
cmludCkmI3hEOzA5NTktNTM1WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+ODYxMTgz
MDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2Jp
Lm5sbS5uaWguZ292L3B1Ym1lZC84NjExODMwPC91cmw+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxt
Lm5paC5nb3YvcG1jL2FydGljbGVzL1BNQzIzNTAyODkvcGRmL2JtajAwNTI4LTAwMjAucGRmPC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzIzNTAyODk8L2N1c3RvbTI+PC9y
ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QmFpbGV5PC9BdXRob3I+PFllYXI+MTk5NzwvWWVh
cj48UmVjTnVtPjE0NDc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE0NDc8L3JlYy1udW1i
ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI5enM1ZXAwYWdlNTBwaWV4ZHQx
eHMyZG16NXIycjJldHhzZDAiIHRpbWVzdGFtcD0iMTQ1NjY5NjgxMyI+MTQ0Nzwva2V5PjwvZm9y
ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48
Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmFpbGV5LCBULiBDLjwvYXV0aG9yPjxhdXRo
b3I+TGl0dGxlLCBKLiBSLjwvYXV0aG9yPjxhdXRob3I+TGl0dGVuYmVyZywgQi48L2F1dGhvcj48
YXV0aG9yPlJlaWNobGV5LCBSLiBNLjwvYXV0aG9yPjxhdXRob3I+RHVuYWdhbiwgVy4gQy48L2F1
dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m
IEludGVybmFsIE1lZGljaW5lLCBXYXNoaW5ndG9uIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGlj
aW5lLCBCYXJuZXMtSmV3aXNoIEhvc3BpdGFsLCBTdC4gTG91aXMsIE1pc3NvdXJpIDYzMTEwLCBV
U0EuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBtZXRhLWFuYWx5c2lzIG9mIGV4dGVu
ZGVkLWludGVydmFsIGRvc2luZyB2ZXJzdXMgbXVsdGlwbGUgZGFpbHkgZG9zaW5nIG9mIGFtaW5v
Z2x5Y29zaWRlczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29u
ZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBE
aXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz43ODYtOTU8L3BhZ2VzPjx2b2x1bWU+
MjQ8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QW1pbm9nbHlj
b3NpZGVzPC9rZXl3b3JkPjxrZXl3b3JkPkFudGktQmFjdGVyaWFsIEFnZW50cy8qYWRtaW5pc3Ry
YXRpb24gJmFtcDsgZG9zYWdlLyphZHZlcnNlIGVmZmVjdHMvcGhhcm1hY29raW5ldGljczwva2V5
d29yZD48a2V5d29yZD5CYWN0ZXJpYWwgSW5mZWN0aW9ucy9kcnVnIHRoZXJhcHkvbWljcm9iaW9s
b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNvbmZpZGVuY2UgSW50ZXJ2YWxzPC9rZXl3b3JkPjxrZXl3
b3JkPkRvc2UtUmVzcG9uc2UgUmVsYXRpb25zaGlwLCBEcnVnPC9rZXl3b3JkPjxrZXl3b3JkPkRy
dWcgQWRtaW5pc3RyYXRpb24gU2NoZWR1bGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcmluZyBEaXNv
cmRlcnMvKmNoZW1pY2FsbHkgaW5kdWNlZDwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdv
cmQ+PGtleXdvcmQ+SW5mdXNpb25zLCBJbnRyYXZlbm91czwva2V5d29yZD48a2V5d29yZD5LaWRu
ZXkgRGlzZWFzZXMvKmNoZW1pY2FsbHkgaW5kdWNlZDwva2V5d29yZD48a2V5d29yZD5SYW5kb21p
emVkIENvbnRyb2xsZWQgVHJpYWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFj
dG9yczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdv
cmRzPjxkYXRlcz48eWVhcj4xOTk3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5PC9kYXRlPjwv
cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA1OC00ODM4IChQcmludCkmI3hEOzEwNTgtNDgzOCAo
TGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+OTE0Mjc3MTwvYWNjZXNzaW9uLW51bT48dXJs
cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85
MTQyNzcxPC91cmw+PHVybD5odHRwOi8vY2lkLm94Zm9yZGpvdXJuYWxzLm9yZy9jb250ZW50LzI0
LzUvNzg2LmZ1bGwucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0
ZT48Q2l0ZT48QXV0aG9yPkJveWVyPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjE0
NTI8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE0NTI8L3JlYy1udW1iZXI+PGZvcmVpZ24t
a2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI5enM1ZXAwYWdlNTBwaWV4ZHQxeHMyZG16NXIycjJl
dHhzZDAiIHRpbWVzdGFtcD0iMTQ1NjY5NzExOCI+MTQ1Mjwva2V5PjwvZm9yZWlnbi1rZXlzPjxy
ZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3Jz
PjxhdXRob3JzPjxhdXRob3I+Qm95ZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5HcnVzb24sIEQuPC9h
dXRob3I+PGF1dGhvcj5Cb3VjaGV0LCBTLjwvYXV0aG9yPjxhdXRob3I+Q2xvdXplYXUsIEIuPC9h
dXRob3I+PGF1dGhvcj5Ib2FuZy1OYW0sIEIuPC9hdXRob3I+PGF1dGhvcj5WYXJnYXMsIEYuPC9h
dXRob3I+PGF1dGhvcj5HaWxsZXMsIEguPC9hdXRob3I+PGF1dGhvcj5Nb2xpbWFyZCwgTS48L2F1
dGhvcj48YXV0aG9yPlJvZ3VlcywgQS4gTS48L2F1dGhvcj48YXV0aG9yPk1vb3JlLCBOLjwvYXV0
aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNlcnZpY2UgZGUgUmVh
bmltYXRpb24gTWVkaWNhbGUsIENIVSBkZSBCb3JkZWF1eCwgMyBwbGFjZSBBbWVsaWUgUmFiYS1M
ZW9uLCAzMzA3NiwgQm9yZGVhdXggQ0VERVgsIEZyYW5jZS4gYWxleGFuZHJlLmJveWVyQGNodS1i
b3JkZWF1eC5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkFtaW5vZ2x5Y29zaWRlcyBp
biBzZXB0aWMgc2hvY2s6IGFuIG92ZXJ2aWV3LCB3aXRoIHNwZWNpZmljIGNvbnNpZGVyYXRpb24g
Z2l2ZW4gdG8gdGhlaXIgbmVwaHJvdG94aWMgcmlzazwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5E
cnVnIFNhZjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkRydWcgU2FmPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MjE3LTMwPC9wYWdlcz48
dm9sdW1lPjM2PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFt
aW5vZ2x5Y29zaWRlcy9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvKmFkdmVyc2UgZWZmZWN0
czwva2V5d29yZD48a2V5d29yZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvYWRtaW5pc3RyYXRpb24g
JmFtcDsgZG9zYWdlLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+RHJ1ZyBNb25p
dG9yaW5nLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y
ZD5LaWRuZXkvZHJ1ZyBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlJlbmFsIEluc3VmZmljaWVu
Y3kvKmNoZW1pY2FsbHkgaW5kdWNlZDwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tl
eXdvcmQ+PGtleXdvcmQ+U2hvY2ssIFNlcHRpYy8qY2hlbWljYWxseSBpbmR1Y2VkPC9rZXl3b3Jk
Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8
L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMTE0LTU5MTYgKFByaW50KSYjeEQ7MDEx
NC01OTE2IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzUwODU0NDwvYWNjZXNzaW9u
LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292
L3B1Ym1lZC8yMzUwODU0NDwvdXJsPjx1cmw+aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tL2FydGlj
bGUvMTAuMTAwNyUyRnM0MDI2NC0wMTMtMDAzMS0wPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz
PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDA3L3M0MDI2NC0wMTMtMDAzMS0wPC9lbGVj
dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5PbGl2ZWly
YTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051bT41PC9SZWNOdW0+PHJlY29yZD48cmVj
LW51bWJlcj41PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i
OXpzNWVwMGFnZTUwcGlleGR0MXhzMmRtejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE0NDAyNjM1
MTkiPjU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl
Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk9saXZlaXJhLCBN
LiBTLjwvYXV0aG9yPjxhdXRob3I+UHJhZG8sIEcuIFYuPC9hdXRob3I+PGF1dGhvcj5Db3N0YSwg
Uy4gRi48L2F1dGhvcj48YXV0aG9yPkdyaW5iYXVtLCBSLiBTLjwvYXV0aG9yPjxhdXRob3I+TGV2
aW4sIEEuIFMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+
RGVwYXJ0bWVudCBvZiBJbmZlY3Rpb24gQ29udHJvbCBvZiBIb3NwaXRhbCBkYXMgQ2xpbmljYXMs
IFJ1YSBEci4gT3ZpZGlvIFBpcmVzIGRlIENhbXBvcywgU2FvIFBhdWxvLVNQIDA1NDAzLTAxMCwg
QnJhemlsLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBvbHlteXhpbiBCIGFuZCBjb2xp
c3RpbWV0aGF0ZSBhcmUgY29tcGFyYWJsZSBhcyB0byBlZmZpY2FjeSBhbmQgcmVuYWwgdG94aWNp
dHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RGlhZ24gTWljcm9iaW9sIEluZmVjdCBEaXM8L3Nl
Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5EaWFnbiBNaWNy
b2Jpb2wgSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjQzMS00PC9w
YWdlcz48dm9sdW1lPjY1PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3
b3JkPkFjaW5ldG9iYWN0ZXIgSW5mZWN0aW9ucy8qZHJ1ZyB0aGVyYXB5PC9rZXl3b3JkPjxrZXl3
b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+
QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29y
ZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvYWR2ZXJzZSBlZmZlY3RzL3RoZXJhcGV1dGljIHVzZTwv
a2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5Db2xpc3Rpbi9hZHZlcnNl
IGVmZmVjdHMvKmFuYWxvZ3MgJmFtcDsgZGVyaXZhdGl2ZXMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3
b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl
eXdvcmQ+S2lkbmV5LypkcnVnIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29y
ZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Qb2x5bXl4aW4gQi8qYWR2
ZXJzZSBlZmZlY3RzLyp0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50
IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+WW91bmcgQWR1bHQ8L2tleXdvcmQ+PC9rZXl3b3Jk
cz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYzwvZGF0ZT48L3B1
Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4NzktMDA3MCAoRWxlY3Ryb25pYykmI3hEOzA3MzItODg5
MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk3MzMwMjk8L2FjY2Vzc2lvbi1udW0+
PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJt
ZWQvMTk3MzMwMjk8L3VybD48dXJsPmh0dHA6Ly93d3cuZG1pZGpvdXJuYWwuY29tL2FydGljbGUv
UzA3MzItODg5MygwOSkwMDI5OC0zL2Fic3RyYWN0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz
PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouZGlhZ21pY3JvYmlvLjIwMDkuMDcu
MDE4PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv
cj5Ba2FqYWdib3I8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NjwvUmVjTnVtPjxy
ZWNvcmQ+PHJlYy1udW1iZXI+NjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF
TiIgZGItaWQ9Ijl6czVlcDBhZ2U1MHBpZXhkdDF4czJkbXo1cjJyMmV0eHNkMCIgdGltZXN0YW1w
PSIxNDQwMjYzNTY2Ij42PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu
YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5B
a2FqYWdib3IsIEQuIFMuPC9hdXRob3I+PGF1dGhvcj5XaWxzb24sIFMuIEwuPC9hdXRob3I+PGF1
dGhvcj5TaGVyZS1Xb2xmZSwgSy4gRC48L2F1dGhvcj48YXV0aG9yPkRha3VtLCBQLjwvYXV0aG9y
PjxhdXRob3I+Q2hhcnVyYXQsIE0uIEUuPC9hdXRob3I+PGF1dGhvcj5HaWxsaWFtLCBCLiBMLjwv
YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQg
b2YgUGhhcm1hY3kgUHJhY3RpY2UsIEQmYXBvcztZb3V2aWxsZSBDb2xsZWdlIFNjaG9vbCBvZiBQ
aGFybWFjeSwgQnVmZmFsby48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5IaWdoZXIgaW5j
aWRlbmNlIG9mIGFjdXRlIGtpZG5leSBpbmp1cnkgd2l0aCBpbnRyYXZlbm91cyBjb2xpc3RpbWV0
aGF0ZSBzb2RpdW0gY29tcGFyZWQgd2l0aCBwb2x5bXl4aW4gQiBpbiBjcml0aWNhbGx5IGlsbCBw
YXRpZW50cyBhdCBhIHRlcnRpYXJ5IGNhcmUgbWVkaWNhbCBjZW50ZXI8L3RpdGxlPjxzZWNvbmRh
cnktdGl0bGU+Q2xpbiBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlv
ZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbiBJbmZlY3QgRGlzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh
bD48cGFnZXM+MTMwMC0zPC9wYWdlcz48dm9sdW1lPjU3PC92b2x1bWU+PG51bWJlcj45PC9udW1i
ZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIEtpZG5leSBJbmp1cnkvKmNoZW1pY2FsbHkgaW5k
dWNlZC8qZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFkbWluaXN0cmF0aW9uLCBJbnRy
YXZlbm91czwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9r
ZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkFudGkt
QmFjdGVyaWFsIEFnZW50cy9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvKmFkdmVyc2UgZWZm
ZWN0czwva2V5d29yZD48a2V5d29yZD5Db2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5D
b2xpc3Rpbi9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvYWR2ZXJzZSBlZmZlY3RzLyphbmFs
b2dzICZhbXA7IGRlcml2YXRpdmVzPC9rZXl3b3JkPjxrZXl3b3JkPkNyaXRpY2FsIElsbG5lc3M8
L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29y
ZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5
d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Qb2x5bXl4aW4gQi9hZG1pbmlzdHJh
dGlvbiAmYW1wOyBkb3NhZ2UvKmFkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5SZXRy
b3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+VGVydGlhcnkgQ2FyZSBDZW50ZXJz
PC9rZXl3b3JkPjxrZXl3b3JkPkFraTwva2V5d29yZD48a2V5d29yZD5QYjwva2V5d29yZD48a2V5
d29yZD5jb2xpc3RpbWV0aGF0ZSBzb2RpdW08L2tleXdvcmQ+PGtleXdvcmQ+Y29saXN0aW48L2tl
eXdvcmQ+PGtleXdvcmQ+bmVwaHJvdG94aWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+
PHllYXI+MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdjwvZGF0ZT48L3B1Yi1kYXRlcz48
L2RhdGVzPjxpc2JuPjE1MzctNjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2lu
Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM4NDAwMDA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJl
bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjM4NDAw
MDA8L3VybD48dXJsPmh0dHA6Ly9jaWQub3hmb3Jkam91cm5hbHMub3JnL2NvbnRlbnQvNTcvOS8x
MzAwLmZ1bGwucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291
cmNlLW51bT4xMC4xMDkzL2NpZC9jaXQ0NTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVj
b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlR1b248L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
ZWNOdW0+NzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NzwvcmVjLW51bWJlcj48Zm9yZWln
bi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9Ijl6czVlcDBhZ2U1MHBpZXhkdDF4czJkbXo1cjJy
MmV0eHNkMCIgdGltZXN0YW1wPSIxNDQwMjYzNTgyIj43PC9rZXk+PC9mb3JlaWduLWtleXM+PHJl
Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+
PGF1dGhvcnM+PGF1dGhvcj5UdW9uLCBGLiBGLjwvYXV0aG9yPjxhdXRob3I+UmlnYXR0bywgTS4g
SC48L2F1dGhvcj48YXV0aG9yPkxvcGVzLCBDLiBLLjwvYXV0aG9yPjxhdXRob3I+S2FtZWksIEwu
IEsuPC9hdXRob3I+PGF1dGhvcj5Sb2NoYSwgSi4gTC48L2F1dGhvcj48YXV0aG9yPlphdmFzY2tp
LCBBLiBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRp
dmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIEhvc3BpdGFsIGRlIENsaW5pY2FzIGRhIFVu
aXZlcnNpZGFkZSBGZWRlcmFsIGRvIFBhcmFuYSAoVUZQUiksIEN1cml0aWJhLCBQYXJhbmEsIEJy
YXppbDsgRGl2aXNpb24gb2YgSW5mZWN0aW91cyBhbmQgUGFyYXNpdGljIERpc2Vhc2VzLCBIb3Nw
aXRhbCBVbml2ZXJzaXRhcmlvIEV2YW5nZWxpY28gZGUgQ3VyaXRpYmEsIEN1cml0aWJhLCBQYXJh
bmEsIEJyYXppbC4mI3hEO0luZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSwgSG9zcGl0YWwgU2Fv
IEx1Y2FzIGRhIFBvbnRpZmljaWEgVW5pdmVyc2lkYWRlIENhdG9saWNhIGRvIFJpbyBHcmFuZGUg
ZG8gU3VsIChQVUNSUyksIFBvcnRvIEFsZWdyZSwgUlMsIEJyYXppbC4mI3hEO0RpdmlzaW9uIG9m
IEluZmVjdGlvdXMgYW5kIFBhcmFzaXRpYyBEaXNlYXNlcywgSG9zcGl0YWwgVW5pdmVyc2l0YXJp
byBFdmFuZ2VsaWNvIGRlIEN1cml0aWJhLCBDdXJpdGliYSwgUGFyYW5hLCBCcmF6aWwuJiN4RDtE
aXZpc2lvbiBvZiBNaWNyb2Jpb2xvZ3ksIEZyaXNjaG1hbm4gQWlzZW5nYXJ0L0RBU0EgTWVkaWNp
bmEgRGlhZ25vc3RpY2EsIEN1cml0aWJhLCBQYXJhbmEsIEJyYXppbC4mI3hEO0RlcGFydG1lbnQg
b2YgSW50ZXJuYWwgTWVkaWNpbmUsIFNjaG9vbCBvZiBNZWRpY2luZSwgVW5pdmVyc2lkYWRlIEZl
ZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBTdWwsIFBvcnRvIEFsZWdyZSwgUlMsIEJyYXppbDsgSW5m
ZWN0aW91cyBEaXNlYXNlcyBTZXJ2aWNlLCBIb3NwaXRhbCBkZSBDbGluaWNhcyBkZSBQb3J0byBB
bGVncmUsIDIzNTAgUnVhIFJhbWlybyBCYXJjZWxvcywgOTAuMDM1LTkwMyBQb3J0byBBbGVncmUs
IFJTLCBCcmF6aWwuIEVsZWN0cm9uaWMgYWRkcmVzczogYXphdmFzY2tpQGhjcGEudWZyZ3MuYnIu
PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmlzayBmYWN0b3JzIGZvciBhY3V0ZSBraWRu
ZXkgaW5qdXJ5IGluIHBhdGllbnRzIHRyZWF0ZWQgd2l0aCBwb2x5bXl4aW4gQiBvciBjb2xpc3Rp
biBtZXRoYW5lc3VsZm9uYXRlIHNvZGl1bTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5JbnQgSiBB
bnRpbWljcm9iIEFnZW50czwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm
dWxsLXRpdGxlPkludCBKIEFudGltaWNyb2IgQWdlbnRzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh
bD48cGFnZXM+MzQ5LTUyPC9wYWdlcz48dm9sdW1lPjQzPC92b2x1bWU+PG51bWJlcj40PC9udW1i
ZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjaW5ldG9iYWN0ZXIgSW5mZWN0aW9ucy9kcnVnIHRoZXJh
cHk8L2tleXdvcmQ+PGtleXdvcmQ+QWNpbmV0b2JhY3RlciBiYXVtYW5uaWkvZHJ1ZyBlZmZlY3Rz
L3BhdGhvZ2VuaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+QWN1dGUgS2lkbmV5IEluanVyeS8qY2hl
bWljYWxseSBpbmR1Y2VkLyplcGlkZW1pb2xvZ3kvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3Jk
PkFudGktQmFjdGVyaWFsIEFnZW50cy9hZHZlcnNlIGVmZmVjdHMvdGhlcmFwZXV0aWMgdXNlPC9r
ZXl3b3JkPjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkNvbGlzdGlu
L2FkdmVyc2UgZWZmZWN0cy8qYW5hbG9ncyAmYW1wOyBkZXJpdmF0aXZlcy90aGVyYXBldXRpYyB1
c2U8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhvc3BpdGFsIE1v
cnRhbGl0eTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+S2xlYnNp
ZWxsYSBJbmZlY3Rpb25zL2RydWcgdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5LbGVic2llbGxh
IHBuZXVtb25pYWUvZHJ1ZyBlZmZlY3RzL3BhdGhvZ2VuaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+
TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Qb2x5
bXl4aW4gQi8qYWR2ZXJzZSBlZmZlY3RzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29y
ZD5Qc2V1ZG9tb25hcyBJbmZlY3Rpb25zL2RydWcgdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5Q
c2V1ZG9tb25hcyBhZXJ1Z2lub3NhL2RydWcgZWZmZWN0cy9wYXRob2dlbmljaXR5PC9rZXl3b3Jk
PjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZh
Y3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VmFuY29teWNpbi8qYWR2ZXJzZSBlZmZlY3RzL3RoZXJh
cGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5BY3V0ZSBLaWRuZXkgSW5qdXJ5IE5ldHdvcms8
L2tleXdvcmQ+PGtleXdvcmQ+QWN1dGUga2lkbmV5IGluanVyeTwva2V5d29yZD48a2V5d29yZD5B
Y3V0ZSByZW5hbCBmYWlsdXJlPC9rZXl3b3JkPjxrZXl3b3JkPkNvaG9ydCBzdHVkeTwva2V5d29y
ZD48a2V5d29yZD5Db2xpc3Rpbjwva2V5d29yZD48a2V5d29yZD5DcmVhdGluaW5lPC9rZXl3b3Jk
PjxrZXl3b3JkPlBvbHlteXhpbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0
PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz
Ym4+MTg3Mi03OTEzIChFbGVjdHJvbmljKSYjeEQ7MDkyNC04NTc5IChMaW5raW5nKTwvaXNibj48
YWNjZXNzaW9uLW51bT4yNDQzOTA2NjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxz
Pjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yNDQzOTA2NjwvdXJsPjx1
cmw+aHR0cDovL3d3dy5pamFhb25saW5lLmNvbS9hcnRpY2xlL1MwOTI0LTg1NzkoMTMpMDAzOTEt
OS9hYnN0cmFjdDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJj
ZS1udW0+MTAuMTAxNi9qLmlqYW50aW1pY2FnLjIwMTMuMTIuMDAyPC9lbGVjdHJvbmljLXJlc291
cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5QaGU8L0F1dGhvcj48WWVhcj4y
MDE0PC9ZZWFyPjxSZWNOdW0+ODwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+ODwvcmVjLW51
bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9Ijl6czVlcDBhZ2U1MHBpZXhk
dDF4czJkbXo1cjJyMmV0eHNkMCIgdGltZXN0YW1wPSIxNDQwMjYzNjAxIj44PC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QaGUsIEsuPC9hdXRob3I+PGF1dGhvcj5MZWUs
IFkuPC9hdXRob3I+PGF1dGhvcj5NY0RhbmVsZCwgUC4gTS48L2F1dGhvcj48YXV0aG9yPlByYXNh
ZCwgTi48L2F1dGhvcj48YXV0aG9yPllpbiwgVC48L2F1dGhvcj48YXV0aG9yPkZpZ3Vlcm9hLCBE
LiBBLjwvYXV0aG9yPjxhdXRob3I+TXVzaWNrLCBXLiBMLjwvYXV0aG9yPjxhdXRob3I+Q290dHJl
YXUsIEouIE0uPC9hdXRob3I+PGF1dGhvcj5IdSwgTS48L2F1dGhvcj48YXV0aG9yPlRhbSwgVi4g
SC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRt
ZW50IG9mIFBoYXJtYWN5LCBTdC4gTHVrZSZhcG9zO3MgRXBpc2NvcGFsIEhvc3BpdGFsLCBIb3Vz
dG9uLCBUZXhhcywgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkluIHZpdHJvIGFz
c2Vzc21lbnQgYW5kIG11bHRpY2VudGVyIGNvaG9ydCBzdHVkeSBvZiBjb21wYXJhdGl2ZSBuZXBo
cm90b3hpY2l0eSByYXRlcyBhc3NvY2lhdGVkIHdpdGggY29saXN0aW1ldGhhdGUgdmVyc3VzIHBv
bHlteXhpbiBCIHRoZXJhcHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW50aW1pY3JvYiBBZ2Vu
dHMgQ2hlbW90aGVyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt
dGl0bGU+QW50aW1pY3JvYiBBZ2VudHMgQ2hlbW90aGVyPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh
bD48cGFnZXM+Mjc0MC02PC9wYWdlcz48dm9sdW1lPjU4PC92b2x1bWU+PG51bWJlcj41PC9udW1i
ZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFudGktQmFjdGVy
aWFsIEFnZW50cy9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvKmFkdmVyc2UgZWZmZWN0czwv
a2V5d29yZD48a2V5d29yZD5DZWxsIExpbmU8L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBTdXJ2aXZh
bC9kcnVnIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+Q29saXN0aW4vYWRtaW5pc3RyYXRpb24g
JmFtcDsgZG9zYWdlL2FkdmVyc2UgZWZmZWN0cy8qYW5hbG9ncyAmYW1wOyBkZXJpdmF0aXZlczwv
a2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+S2lkbmV5L2RydWcgZWZm
ZWN0czwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Qb2x5
bXl4aW5zL2FkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZS8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3
b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48L2tleXdvcmRzPjxk
YXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5PC9kYXRlPjwvcHViLWRh
dGVzPjwvZGF0ZXM+PGlzYm4+MTA5OC02NTk2IChFbGVjdHJvbmljKSYjeEQ7MDA2Ni00ODA0IChM
aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNDU2NjE4NzwvYWNjZXNzaW9uLW51bT48dXJs
cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8y
NDU2NjE4NzwvdXJsPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3BtYy9hcnRpY2xl
cy9QTUMzOTkzMjIxL3BkZi96YWMyNzQwLnBkZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48
Y3VzdG9tMj5QTUMzOTkzMjIxPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4x
MTI4L0FBQy4wMjQ3Ni0xMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl
PjxDaXRlPjxBdXRob3I+UmlnYXR0bzwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4x
NDU1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xNDU1PC9yZWMtbnVtYmVyPjxmb3JlaWdu
LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVwMGFnZTUwcGlleGR0MXhzMmRtejVyMnIy
ZXR4c2QwIiB0aW1lc3RhbXA9IjE0NTY2OTkyNTciPjE0NTU8L2tleT48L2ZvcmVpZ24ta2V5cz48
cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y
cz48YXV0aG9ycz48YXV0aG9yPlJpZ2F0dG8sIE0uIEguPC9hdXRob3I+PGF1dGhvcj5PbGl2ZWly
YSwgTS4gUy48L2F1dGhvcj48YXV0aG9yPlBlcmRpZ2FvLU5ldG8sIEwuIFYuPC9hdXRob3I+PGF1
dGhvcj5MZXZpbiwgQS4gUy48L2F1dGhvcj48YXV0aG9yPkNhcnJpbGhvLCBDLiBNLjwvYXV0aG9y
PjxhdXRob3I+VGFuaXRhLCBNLiBULjwvYXV0aG9yPjxhdXRob3I+VHVvbiwgRi4gRi48L2F1dGhv
cj48YXV0aG9yPkNhcmRvc28sIEQuIEUuPC9hdXRob3I+PGF1dGhvcj5Mb3BlcywgTi4gVC48L2F1
dGhvcj48YXV0aG9yPkZhbGNpLCBELiBSLjwvYXV0aG9yPjxhdXRob3I+WmF2YXNja2ksIEEuIFAu
PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+SW5mZWN0aW91
cyBEaXNlYXNlcyBTZXJ2aWNlLCBIb3NwaXRhbCBTYW8gTHVjYXMgZGEgUG9udGlmaWNpYSBVbml2
ZXJzaWRhZGUgQ2F0b2xpY2EgZG8gUmlvIEdyYW5kZSBkbyBTdWwsIFBvcnRvIEFsZWdyZSwgQnJh
emlsIEluZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSwgSG9zcGl0YWwgZGUgQ2xpbmljYXMgZGUg
UG9ydG8gQWxlZ3JlLCBQb3J0byBBbGVncmUsIEJyYXppbC4mI3hEO0RlcGFydG1lbnQgb2YgSW5m
ZWN0aW9uIENvbnRyb2wsIEhvc3BpdGFsIGRhcyBDbGluaWNhcyBkYSBGYWN1bGRhZGUgZGUgTWVk
aWNpbmEgZGEgVW5pdmVyc2lkYWRlIGRlIFNhbyBQYXVsbywgU2FvIFBhdWxvLCBCcmF6aWwgRGVw
YXJ0bWVudCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBMYWJvcmF0b3JpbyBkZSBJbnZlc3RpZ2Fj
YW8gTWVkaWNhLCBMSU0gNTQsIGFuZCBJbnN0aXR1dG8gZGUgTWVkaWNpbmEgVHJvcGljYWwsIFVu
aXZlcnNpdHkgb2YgU2FvIFBhdWxvLCBTYW8gUGF1bG8sIEJyYXppbC4mI3hEO0ludGVuc2l2ZSBD
YXJlIFVuaXQsIFVuaXZlcnNpZGFkZSBFc3RhZHVhbCBkZSBMb25kcmluYSwgTG9uZHJpbmEsIEJy
YXppbC4mI3hEO0luZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSwgVW5pdmVyc2lkYWRlIEZlZGVy
YWwgZGUgQ3VyaXRpYmEsIEN1cml0aWJhLCBCcmF6aWwuJiN4RDtNZWRpY2FsIFNjaG9vbCwgVW5p
dmVyc2lkYWRlIEZlZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBTdWwsIFBvcnRvIEFsZWdyZSwgQnJh
emlsLiYjeEQ7SW5mZWN0aW91cyBEaXNlYXNlcyBTZXJ2aWNlLCBIb3NwaXRhbCBkZSBDbGluaWNh
cyBkZSBQb3J0byBBbGVncmUsIFBvcnRvIEFsZWdyZSwgQnJhemlsIEluZmVjdGlvbiBDb250cm9s
IFNlcnZpY2UsIEhvc3BpdGFsIE5vc3NhIFNlbmhvcmEgZGEgQ29uY2VpY2FvLCBQb3J0byBBbGVn
cmUsIEJyYXppbC4mI3hEO0luZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSwgSG9zcGl0YWwgZGUg
Q2xpbmljYXMgZGUgUG9ydG8gQWxlZ3JlLCBQb3J0byBBbGVncmUsIEJyYXppbCBEZXBhcnRtZW50
IG9mIEludGVybmFsIE1lZGljaW5lLCBNZWRpY2FsIFNjaG9vbCwgVW5pdmVyc2lkYWRlIEZlZGVy
YWwgZG8gUmlvIEdyYW5kZSBkbyBTdWwsIFBvcnRvIEFsZWdyZSwgQnJhemlsIGF6YXZhc2NraUBo
Y3BhLmVkdS5ici48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5NdWx0aWNlbnRlciBQcm9z
cGVjdGl2ZSBDb2hvcnQgU3R1ZHkgb2YgUmVuYWwgRmFpbHVyZSBpbiBQYXRpZW50cyBUcmVhdGVk
IHdpdGggQ29saXN0aW4gdmVyc3VzIFBvbHlteXhpbiBCPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl
PkFudGltaWNyb2IgQWdlbnRzIENoZW1vdGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxw
ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFudGltaWNyb2IgQWdlbnRzIENoZW1vdGhlcjwvZnVsbC10
aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjI0NDMtOTwvcGFnZXM+PHZvbHVtZT42MDwvdm9sdW1l
PjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BY3V0ZSBLaWRuZXkgSW5qdXJ5
LypjaGVtaWNhbGx5IGluZHVjZWQvZHJ1ZyB0aGVyYXB5L21vcnRhbGl0eS9wYXRob2xvZ3k8L2tl
eXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdv
cmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5
d29yZD48a2V5d29yZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvYWRtaW5pc3RyYXRpb24gJmFtcDsg
ZG9zYWdlLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+Qm9keSBXZWlnaHQ8L2tl
eXdvcmQ+PGtleXdvcmQ+Q29saXN0aW4vYWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlL2FkdmVy
c2UgZWZmZWN0cy8qYW5hbG9ncyAmYW1wOyBkZXJpdmF0aXZlczwva2V5d29yZD48a2V5d29yZD5E
cnVnIEFkbWluaXN0cmF0aW9uIFNjaGVkdWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5
d29yZD48a2V5d29yZD5HcmFtLU5lZ2F0aXZlIEJhY3RlcmlhL2RydWcgZWZmZWN0cy9ncm93dGgg
JmFtcDsgZGV2ZWxvcG1lbnQvcGF0aG9nZW5pY2l0eTwva2V5d29yZD48a2V5d29yZD5HcmFtLU5l
Z2F0aXZlIEJhY3RlcmlhbCBJbmZlY3Rpb25zL2RydWcgdGhlcmFweS9taWNyb2Jpb2xvZ3kvbW9y
dGFsaXR5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv
cmQ+SW50ZW5zaXZlIENhcmUgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SW50cmFhYmRvbWluYWwg
SW5mZWN0aW9ucy9kcnVnIHRoZXJhcHkvbWljcm9iaW9sb2d5L21vcnRhbGl0eS9wYXRob2xvZ3k8
L2tleXdvcmQ+PGtleXdvcmQ+S2lkbmV5IEZhaWx1cmUsIENocm9uaWMvKmNoZW1pY2FsbHkgaW5k
dWNlZC9kcnVnIHRoZXJhcHkvbW9ydGFsaXR5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5N
YWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk11bHRp
dmFyaWF0ZSBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5Qb2x5bXl4aW4gQi9hZG1pbmlzdHJh
dGlvbiAmYW1wOyBkb3NhZ2UvKmFkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5Qcm9z
cGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFRyYWN0IEluZmVj
dGlvbnMvZHJ1ZyB0aGVyYXB5L21pY3JvYmlvbG9neS9tb3J0YWxpdHkvcGF0aG9sb2d5PC9rZXl3
b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZhbCBBbmFs
eXNpczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjxwdWItZGF0
ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5OC02NTk2IChF
bGVjdHJvbmljKSYjeEQ7MDA2Ni00ODA0IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4y
Njg1Njg0NjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3
dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yNjg1Njg0NjwvdXJsPjwvcmVsYXRlZC11cmxzPjwv
dXJscz48Y3VzdG9tMj5QTUM0ODA4MjM3PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51
bT4xMC4xMTI4L0FBQy4wMjYzNC0xNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+
PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE.DATA 34,41-47 Additionally, although both classes have narrow therapeutic indices, aminoglycosides have validated therapeutic drug monitoring targets upon which therapy can be tailored to individual patients. Polymyxins may be considered for isolates only susceptible to aminoglycosides with elevated minimum inhibitory concentration (MIC) values (i.e. amikacin MIC = 16) which make achieving pharmacodynamic targets unlikely.Inhaled Therapy with ColistinVentilator-associated tracheobronchitis is NOT an indication for inhaled antibiotic therapy either alone or in combination with systemic antibioticsRationale: The role of inhaled antibiotics in the treatment of ventilator-associated tracheobronchitis has not been clearly defined. Clinical outcomes data are limited; however, no effect on mortality, ICU length of stay, or hospital length of stay has been clearly demonstrated.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYWxpbDwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYWxpbDwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl
Y051bT4yNTEzPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+
NDA8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4yNTEzPC9yZWMtbnVt
YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iOXpzNWVwMGFnZTUwcGlleGR0
MXhzMmRtejVyMnIyZXR4c2QwIiB0aW1lc3RhbXA9IjE0ODI5NzEyMDUiPjI1MTM8L2tleT48L2Zv
cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+
PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkthbGlsLCBBLiBDLjwvYXV0aG9yPjxhdXRo
b3I+TWV0ZXJza3ksIE0uIEwuPC9hdXRob3I+PGF1dGhvcj5LbG9tcGFzLCBNLjwvYXV0aG9yPjxh
dXRob3I+TXVzY2VkZXJlLCBKLjwvYXV0aG9yPjxhdXRob3I+U3dlZW5leSwgRC4gQS48L2F1dGhv
cj48YXV0aG9yPlBhbG1lciwgTC4gQi48L2F1dGhvcj48YXV0aG9yPk5hcG9saXRhbm8sIEwuIE0u
PC9hdXRob3I+PGF1dGhvcj5PJmFwb3M7R3JhZHksIE4uIFAuPC9hdXRob3I+PGF1dGhvcj5CYXJ0
bGV0dCwgSi4gRy48L2F1dGhvcj48YXV0aG9yPkNhcnJhdGFsYSwgSi48L2F1dGhvcj48YXV0aG9y
PkVsIFNvbGgsIEEuIEEuPC9hdXRob3I+PGF1dGhvcj5Fd2lnLCBTLjwvYXV0aG9yPjxhdXRob3I+
RmV5LCBQLiBELjwvYXV0aG9yPjxhdXRob3I+RmlsZSwgVC4gTS4sIEpyLjwvYXV0aG9yPjxhdXRo
b3I+UmVzdHJlcG8sIE0uIEkuPC9hdXRob3I+PGF1dGhvcj5Sb2JlcnRzLCBKLiBBLjwvYXV0aG9y
PjxhdXRob3I+V2F0ZXJlciwgRy4gVy48L2F1dGhvcj48YXV0aG9yPkNydXNlLCBQLjwvYXV0aG9y
PjxhdXRob3I+S25pZ2h0LCBTLiBMLjwvYXV0aG9yPjxhdXRob3I+QnJvemVrLCBKLiBMLjwvYXV0
aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2Yg
SW50ZXJuYWwgTWVkaWNpbmUsIERpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIFVuaXZl
cnNpdHkgb2YgTmVicmFza2EgTWVkaWNhbCBDZW50ZXIsIE9tYWhhLiYjeEQ7RGl2aXNpb24gb2Yg
UHVsbW9uYXJ5IGFuZCBDcml0aWNhbCBDYXJlIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIENvbm5l
Y3RpY3V0IFNjaG9vbCBvZiBNZWRpY2luZSwgRmFybWluZ3Rvbi4mI3hEO0JyaWdoYW0gYW5kIFdv
bWVuJmFwb3M7cyBIb3NwaXRhbCBhbmQgSGFydmFyZCBNZWRpY2FsIFNjaG9vbCBIYXJ2YXJkIFBp
bGdyaW0gSGVhbHRoIENhcmUgSW5zdGl0dXRlLCBCb3N0b24sIE1hc3NhY2h1c2V0dHMuJiN4RDtE
ZXBhcnRtZW50IG9mIE1lZGljaW5lLCBDcml0aWNhbCBDYXJlIFByb2dyYW0sIFF1ZWVucyBVbml2
ZXJzaXR5LCBLaW5nc3RvbiwgT250YXJpbywgQ2FuYWRhLiYjeEQ7RGl2aXNpb24gb2YgUHVsbW9u
YXJ5LCBDcml0aWNhbCBDYXJlIGFuZCBTbGVlcCBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBDYWxp
Zm9ybmlhLCBTYW4gRGllZ28uJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBEaXZpc2lvbiBv
ZiBQdWxtb25hcnkgQ3JpdGljYWwgQ2FyZSBhbmQgU2xlZXAgTWVkaWNpbmUsIFN0YXRlIFVuaXZl
cnNpdHkgb2YgTmV3IFlvcmsgYXQgU3RvbnkgQnJvb2suJiN4RDtEZXBhcnRtZW50IG9mIFN1cmdl
cnksIERpdmlzaW9uIG9mIFRyYXVtYSwgQ3JpdGljYWwgQ2FyZSBhbmQgRW1lcmdlbmN5IFN1cmdl
cnksIFVuaXZlcnNpdHkgb2YgTWljaGlnYW4sIEFubiBBcmJvci4mI3hEO0RlcGFydG1lbnQgb2Yg
Q3JpdGljYWwgQ2FyZSBNZWRpY2luZSwgTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJl
dGhlc2RhLiYjeEQ7Sm9obnMgSG9wa2lucyBVbml2ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwg
QmFsdGltb3JlLCBNYXJ5bGFuZC4mI3hEO0RlcGFydG1lbnQgb2YgSW5mZWN0aW91cyBEaXNlYXNl
cywgSG9zcGl0YWwgVW5pdmVyc2l0YXJpIGRlIEJlbGx2aXRnZSwgQmVsbHZpdGdlIEJpb21lZGlj
YWwgUmVzZWFyY2ggSW5zdGl0dXRlLCBTcGFuaXNoIE5ldHdvcmsgZm9yIFJlc2VhcmNoIGluIElu
ZmVjdGlvdXMgRGlzZWFzZXMsIFVuaXZlcnNpdHkgb2YgQmFyY2Vsb25hLCBTcGFpbi4mI3hEO0Rl
cGFydG1lbnQgb2YgTWVkaWNpbmUsIERpdmlzaW9uIG9mIFB1bG1vbmFyeSwgQ3JpdGljYWwgQ2Fy
ZSBhbmQgU2xlZXAgTWVkaWNpbmUsIFVuaXZlcnNpdHkgYXQgQnVmZmFsbywgVmV0ZXJhbnMgQWZm
YWlycyBXZXN0ZXJuIE5ldyBZb3JrIEhlYWx0aGNhcmUgU3lzdGVtLCBOZXcgWW9yay4mI3hEO1Ro
b3JheHplbnRydW0gUnVocmdlYmlldCwgRGVwYXJ0bWVudCBvZiBSZXNwaXJhdG9yeSBhbmQgSW5m
ZWN0aW91cyBEaXNlYXNlcywgRVZLIEhlcm5lIGFuZCBBdWd1c3RhLUtyYW5rZW4tQW5zdGFsdCBC
b2NodW0sIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIFBhdGhvbG9neSBhbmQgTWljcm9iaW9s
b2d5LCBVbml2ZXJzaXR5IG9mIE5lYnJhc2thIE1lZGljYWwgQ2VudGVyLCBPbWFoYS4mI3hEO1N1
bW1hIEhlYWx0aCBTeXN0ZW0sIEFrcm9uLCBPaGlvLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2lu
ZSwgRGl2aXNpb24gb2YgUHVsbW9uYXJ5IGFuZCBDcml0aWNhbCBDYXJlIE1lZGljaW5lLCBTb3V0
aCBUZXhhcyBWZXRlcmFucyBIZWFsdGggQ2FyZSBTeXN0ZW0gYW5kIFVuaXZlcnNpdHkgb2YgVGV4
YXMgSGVhbHRoIFNjaWVuY2UgQ2VudGVyIGF0IFNhbiBBbnRvbmlvLiYjeEQ7QnVybnMsIFRyYXVt
YSBhbmQgQ3JpdGljYWwgQ2FyZSBSZXNlYXJjaCBDZW50cmUsIFRoZSBVbml2ZXJzaXR5IG9mIFF1
ZWVuc2xhbmQgUm95YWwgQnJpc2JhbmUgYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRhbCwgUXVlZW5z
bGFuZC4mI3hEO1NjaG9vbCBvZiBNZWRpY2luZSBhbmQgUGhhcm1hY29sb2d5LCBVbml2ZXJzaXR5
IG9mIFdlc3Rlcm4gQXVzdHJhbGlhLCBQZXJ0aCwgQXVzdHJhbGlhLiYjeEQ7TGlicmFyeSBhbmQg
S25vd2xlZGdlIFNlcnZpY2VzLCBOYXRpb25hbCBKZXdpc2ggSGVhbHRoLCBEZW52ZXIsIENvbG9y
YWRvLiYjeEQ7RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBFcGlkZW1pb2xvZ3kgYW5kIEJpb3N0YXRp
c3RpY3MgYW5kIERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIE1jTWFzdGVyIFVuaXZlcnNpdHksIEhh
bWlsdG9uLCBPbnRhcmlvLCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TWFu
YWdlbWVudCBvZiBBZHVsdHMgV2l0aCBIb3NwaXRhbC1hY3F1aXJlZCBhbmQgVmVudGlsYXRvci1h
c3NvY2lhdGVkIFBuZXVtb25pYTogMjAxNiBDbGluaWNhbCBQcmFjdGljZSBHdWlkZWxpbmVzIGJ5
IHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYSBhbmQgdGhlIEFtZXJp
Y2FuIFRob3JhY2ljIFNvY2lldHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbiBJbmZlY3Qg
RGlzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xp
biBJbmZlY3QgRGlzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTYxLWUxMTE8L3Bh
Z2VzPjx2b2x1bWU+NjM8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAx
NjwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcCAwMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz
Pjxpc2JuPjE1MzctNjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lz
Ym4+PGFjY2Vzc2lvbi1udW0+Mjc0MTg1Nzc8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQt
dXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjc0MTg1Nzc8L3Vy
bD48dXJsPmh0dHA6Ly9jaWQub3hmb3Jkam91cm5hbHMub3JnL2NvbnRlbnQvNjMvNS9lNjEuZnVs
bC5wZGY8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNDk4MTc1OTwvY3Vz
dG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9jaWQvY2l3MzUzPC9lbGVjdHJv
bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA 40 National guidelines recommend against the use of inhaled antibiotic therapy for the treatment of ventilator-associated tracheobronchitis.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYWxpbDwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYWxpbDwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl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ADDIN EN.CITE.DATA 40References ADDIN EN.REFLIST 1.Polymyxin B Sulfate [package insert]. Bedford Laboratories, Bedford, OH; June 2011.2.Coly-Mycin(R) M [package insert]. Par Pharmaceutical, Chestnut Ridge, NY; April 2017.3.Dijkmans AC, Wilms EB, Kamerling IM, et al. Colistin: Revival of an Old Polymyxin Antibiotic. Ther Drug Monit. 2015;37(4):419-427.4.Storm DR, Rosenthal KS, Swanson PE. Polymyxin and related peptide antibiotics. Annu Rev Biochem. 1977;46:723-763.5.CLSI. Performance standards for antimicrobial susceptibility testing; twenty-fourth informational supplement M100-S24. Wayne, PA: Clinical and Laboratory Standards Institute; 2012.6.Sandri AM, Landersdorfer CB, Jacob J, et al. Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens. Clin Infect Dis. 2013;57(4):524-531.7.Garonzik SM, Li J, Thamlikitkul V, et al. Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients. Antimicrob Agents Chemother. 2011;55(7):3284-3294.8.Nation RL, Garonzik SM, Thamlikitkul V, et al. Dosing guidance for intravenous colistin in critically-ill patients. Clin Infect Dis. 2016.9.Zavascki AP, Goldani LZ, Cao G, et al. Pharmacokinetics of intravenous polymyxin B in critically ill patients. Clin Infect Dis. 2008;47(10):1298-1304.10.Thamlikitkul V, Dubrovskaya Y, Manchandani P, et al. Dosing and Pharmacokinetics of Polymyxin B in Patients with Renal Insufficiency. Antimicrob Agents Chemother. 2017;61(1).11.Sandri AM, Landersdorfer CB, Jacob J, et al. Pharmacokinetics of polymyxin B in patients on continuous venovenous haemodialysis. J Antimicrob Chemother. 2013;68(3):674-677.12.Mohamed AF, Karaiskos I, Plachouras D, et al. Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill. Antimicrob Agents Chemother. 2012;56(8):4241-4249.13.Jacobs M, Gregoire N, Megarbane B, et al. Population Pharmacokinetics of Colistin Methanesulfonate and Colistin in Critically Ill Patients with Acute Renal Failure Requiring Intermittent Hemodialysis. Antimicrob Agents Chemother. 2016;60(3):1788-1793.14.Plachouras D, Karvanen M, Friberg LE, et al. Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by gram-negative bacteria. Antimicrob Agents Chemother. 2009;53(8):3430-3436.15.Karaiskos I, Friberg LE, Pontikis K, et al. Colistin Population Pharmacokinetics after Application of a Loading Dose of 9 MU Colistin Methanesulfonate in Critically Ill Patients. Antimicrob Agents Chemother. 2015;59(12):7240-7248.16.Dudhani RV, Turnidge JD, Coulthard K, et al. Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models. Antimicrob Agents Chemother. 2010;54(3):1117-1124.17.Dudhani RV, Turnidge JD, Nation RL, Li J. fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models. J Antimicrob Chemother. 2010;65(9):1984-1990.18.Cheah SE, Wang J, Nguyen VT, Turnidge JD, Li J, Nation RL. New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection. J Antimicrob Chemother. 2015;70(12):3291-3297.19.Li J, Rayner CR, Nation RL, et al. Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2006;50(9):2946-2950.20.Bergen PJ, Tsuji BT, Bulitta JB, et al. Synergistic killing of multidrug-resistant Pseudomonas aeruginosa at multiple inocula by colistin combined with doripenem in an in vitro pharmacokinetic/pharmacodynamic model. Antimicrob Agents Chemother. 2011;55(12):5685-5695.21.Bergen PJ, Forrest A, Bulitta JB, et al. Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula. Antimicrob Agents Chemother. 2011;55(11):5134-5142.22.Bergen PJ, Bulman ZP, Saju S, et al. Polymyxin combinations: pharmacokinetics and pharmacodynamics for rationale use. Pharmacotherapy. 2015;35(1):34-42.23.Sorli L, Luque S, Grau S, et al. Trough colistin plasma level is an independent risk factor for nephrotoxicity: a prospective observational cohort study. BMC infectious diseases. 2013;13:380.24.Zavascki AP, Nation RL. Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B? Antimicrob Agents Chemother. 2017;61(3).25.Vardakas KZ, Falagas ME. Colistin versus polymyxin B for the treatment of patients with multidrug-resistant Gram-negative infections: a systematic review and meta-analysis. Int J Antimicrob Agents. 2017;49(2):233-238.26.Falagas ME, Kasiakou SK. Toxicity of polymyxins: a systematic review of the evidence from old and recent studies. Crit Care. 2006;10(1):R27.27.Ordooei Javan A, Shokouhi S, Sahraei Z. A review on colistin nephrotoxicity. Eur J Clin Pharmacol. 2015;71(7):801-810.28.Lim TP, Hee DK, Lee W, et al. Physicochemical Stability Study of Polymyxin B in Various Infusion Solutions for Administration to Critically Ill Patients. The Annals of pharmacotherapy. 2016;50(9):790-792.29.Elias LS, Konzen D, Krebs JM, Zavascki AP. The impact of polymyxin B dosage on in-hospital mortality of patients treated with this antibiotic. J Antimicrob Chemother. 2010;65(10):2231-2237.30.Nelson BC, Eiras DP, Gomez-Simmonds A, et al. Clinical outcomes associated with polymyxin B dose in patients with bloodstream infections due to carbapenem-resistant Gram-negative rods. Antimicrob Agents Chemother. 2015;59(11):7000-7006.31.Nation RL, Garonzik SM, Li J, et al. Updated US and European Dose Recommendations for Intravenous Colistin: How Do They Perform? Clin Infect Dis. 2016;62(5):552-558.32.Dalfino L, Puntillo F, Mosca A, et al. High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study. Clin Infect Dis. 2012;54(12):1720-1726.33.Benattar YD, Omar M, Zusman O, et al. The Effectiveness and Safety of High-Dose Colistin: Prospective Cohort Study. Clin Infect Dis. 2016;63(12):1605-1612.34.Tuon FF, Rigatto MH, Lopes CK, Kamei LK, Rocha JL, Zavascki AP. Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methanesulfonate sodium. Int J Antimicrob Agents. 2014;43(4):349-352.35.Wenzler E, Fraidenburg DR, Scardina T, Danziger LH. Inhaled Antibiotics for Gram-Negative Respiratory Infections. Clin Microbiol Rev. 2016;29(3):581-632.36.Li J, Coulthard K, Milne R, et al. Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis. J Antimicrob Chemother. 2003;52(6):987-992.37.Reed MD, Stern RC, O'Riordan MA, Blumer JL. The pharmacokinetics of colistin in patients with cystic fibrosis. J Clin Pharmacol. 2001;41(6):645-654.38.Rigatto MH, Vieira FJ, Antochevis LC, Behle TF, Lopes NT, Zavascki AP. Polymyxin B in Combination with Antimicrobials Lacking In Vitro Activity versus Polymyxin B in Monotherapy in Critically Ill Patients with Acinetobacter baumannii or Pseudomonas aeruginosa Infections. Antimicrob Agents Chemother. 2015;59(10):6575-6580.39.Falagas ME, Rafailidis PI, Kasiakou SK, Hatzopoulou P, Michalopoulos A. Effectiveness and nephrotoxicity of colistin monotherapy vs. colistin-meropenem combination therapy for multidrug-resistant Gram-negative bacterial infections. Clin Microbiol Infect. 2006;12(12):1227-1230.40.Kalil AC, Metersky ML, Klompas M, et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):e61-e111.41.Barza M, Ioannidis JP, Cappelleri JC, Lau J. Single or multiple daily doses of aminoglycosides: a meta-analysis. Bmj. 1996;312(7027):338-345.42.Bailey TC, Little JR, Littenberg B, Reichley RM, Dunagan WC. A meta-analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides. Clin Infect Dis. 1997;24(5):786-795.43.Boyer A, Gruson D, Bouchet S, et al. Aminoglycosides in septic shock: an overview, with specific consideration given to their nephrotoxic risk. Drug Saf. 2013;36(4):217-230.44.Oliveira MS, Prado GV, Costa SF, Grinbaum RS, Levin AS. Polymyxin B and colistimethate are comparable as to efficacy and renal toxicity. Diagn Microbiol Infect Dis. 2009;65(4):431-434.45.Akajagbor DS, Wilson SL, Shere-Wolfe KD, Dakum P, Charurat ME, Gilliam BL. Higher incidence of acute kidney injury with intravenous colistimethate sodium compared with polymyxin B in critically ill patients at a tertiary care medical center. Clin Infect Dis. 2013;57(9):1300-1303.46.Phe K, Lee Y, McDaneld PM, et al. In vitro assessment and multicenter cohort study of comparative nephrotoxicity rates associated with colistimethate versus polymyxin B therapy. Antimicrob Agents Chemother. 2014;58(5):2740-2746.47.Rigatto MH, Oliveira MS, Perdigao-Neto LV, et al. Multicenter Prospective Cohort Study of Renal Failure in Patients Treated with Colistin versus Polymyxin B. Antimicrob Agents Chemother. 2016;60(4):2443-2449. ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- day 1 just what are you eating university of arizona
- study guide quiz questions fever 1793
- ecrf completion guidelines cyberchrome inc
- chapter 104 appendix sc dhhs
- pharmaceutical inspection convention
- primary care patient education booklet
- scientific advice request template veterinary
- general outline for antibiotics a good study guide
- 1 all documents the world bank
- michigan medicine university of michigan
Related searches
- university of michigan admissions staff
- university of michigan admission requirement
- university of michigan sat scores
- university of michigan payroll office
- university of michigan application deadline
- university of michigan act requirements
- university of michigan entrance requirements
- university of michigan transfer deadline
- university of michigan philosophy dept
- university of michigan applicant portal
- university of michigan neurology
- university of michigan hospital neurology