Antihypertensive Treatment of Pre-eclampsia;

[Pages:155]Antihypertensive Treatment of Pre-eclampsia; Pharmacological aspects of ketanserin and nicardipine

Lidwien Hanff

? Hanff, L.M. ISBN: 90-8559-156-2

Lay-out and printed by Optima Grafische Communicatie, Rotterdam Cover: ? Marc Chagall, "Maternity" 1912-1913, c/o Beeldrecht Amsterdam 2006.

Antihypertensive Treatment of Pre-eclampsia; Pharmacological aspects of ketanserin and nicardipine

Antihypertensieve behandeling van pre-eclampsie; Farmacologische aspecten van ketanserine en nicardipine

Proefschrift

ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam

op gezag van de rector magnificus Prof.Dr. S.W.J. Lamberts

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 28 juni 2006 om 11.45 uur

door Lidwien Marieke Hanff

geboren te Venlo

PROMOTIECOMMISSIE

Promotoren:

Prof.dr. A.G. Vulto Prof.dr. E.A.P. Steegers

Overige leden:

Prof.dr. A.H.J. Danser Prof.dr. H.W. Bruinse Prof.dr. J.B. van Goudoever

Copromotor: Dr. W. Visser

Voor mijn ouders

CONTENTS

Chapter 1

9

Pharmacological management of severe pre-eclampsia;

Introduction and aims and scope of the thesis.

Chapter 2

Insufficient efficacy of intravenous ketanserin in severe early-onset pre-eclampsia.

Chapter 3

Simultaneous quantitative analysis of ketanserin and ketanserinol in plasma by RP-HPLC with fluorescence detection.

Chapter 4

Population pharmacokinetics of ketanserin in pre-eclamptic patients and its association with antihypertensive response.

Chapter 5

Functional reactivity of 5-HT receptors in human umbilical cord and maternal subcutaneous fat arteries after normotensive or pre-eclamptic pregnancy.

Chapter 6

Ketanserin in pre-eclamptic patients; transplacental transmission, transfer in breast milk and disposition in neonates.

Chapter 7

The effect of maternal ketanserin treatment on foetal 5-HT receptor function in umbilical cord artery of pre-eclamptic patients.

Chapter 8

Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe early-onset pre-eclamptic patients.

Chapter 9

Nicardipine in pre-eclamptic patients: Transplacental transmission and disposition in breast milk.

Chapter 10

General discussion and suggestions for future research

29 39 49 61 79 89 101 119 129

Summary and Conclusions

137

Appendices

143

Samenvatting

144

Dankwoord

151

List of publications related to the thesis

153

About the author

155

 ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download