Chapter 9. Cellular Respiration STAGE 1: Glycolysis

[Pages:18]Chapter 9. Cellular Respiration STAGE 1: Glycolysis

AP Biology

2005-2006

What's the point?

ATP

The Point is to Make ATP!

AP Biology

2005-2006

Glycolysis Breaking down glucose

"glyco ? lysis" (splitting sugar)

glucose pyruvate

6C

2x 3C

most ancient form of energy capture

starting point for all cellular respiration

inefficient

generate only 2 ATP for every 1 glucose

in cytosol

why does that make evolutionary sense?

AP Biology

2005-2006

Evolutionary perspective

Life on Earth first evolved without

free oxygen (O2) in atmosphere

energy had to be captured from organic molecules in absence of O2

Organisms that evolved glycolysis

are ancestors of all modern life

all organisms still utilize glycolysis

You mean, I'm related to them?!

AP Biology

2005-2006

Overview

10 reactions

glucose C-C-C-C-C-C

2 ATPaecnteivrgaytion

convert

2 ADP

6C glucose to two 3C pyruvate

fructose-6P

produce 2 ATP P-C-C-C-C-C-C-P

& 2 NADH

DHAP

PGAL

P-C-C-C C-C-C-P 2 NAD+

2 NADH

4 ADP

pyruvate 4 ATP

AP Biology

C-C-C

2005-2006

Glycolysis summary

endergonic invest some ATP

exergonic harvest a little more ATP & a little NADH

AP Biology

2005-2006

1st half of glycolysis (5 reactions) Glucose

"priming"

get glucose ready to split

phosphorylate glucose

rearrangement

split destabilized glucose

PGAL

Pay attention to AP Biology the enzymes!

2005-2006

2nd half of glycolysis (5 reactions) Oxidation

G3P donates H NAD NADH

ATP generation

G3P pyruvate donates P ADP ATP

Payola!

Finally some

AP Biology

ATP!

2005-2006

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