AP Biology Course Syllabus –2002/2003



Cell and Molecular Biology --- BISC 440, Spring 2006

Lecture: Tu & Th 9:30 – 10:45 AM

Lab Section 1: Tu 3 – 5:50 PM; Section 2: W 12 – 2:50 PM

Instructor: Dr. Bradley W. Jones, 122 Shoemaker Hall

Phone: 915-1700 E-mail: jonesbw@olemiss.edu

Office Hours: Monday 9:00-11:00 AM; Thursday 1:00-3:00 PM; or by appointment

Course Description: This course will give students a rigorous and yet basic understanding and appreciation of the fundamental principles of molecular cell biology. The emphasis of the lectures will be placed on a detailed study of the major cellular components, with particular attention to the relationship between functions and the molecular and supramolecular organization of the cell. We will study the molecular mechanisms for cell reproduction, regulation, control of gene expression, and cellular communication. The laboratory segment of the course will expose students to common molecular biology techniques and methods for observing cells. The emerging field of molecular cell biology, a union of several subfields of biology including genetics, cell biology, biochemistry, and microscopy offers a more comprehensive approach to the understanding of the cell and ultimately, the organism.

Goals of Course: The main goal of this course is for students to gain an understanding of the role of the cell as the fundamental unit of both structure and function in all living things.

Credit Hours: 4

Prerequisites: BISC 336 & BISC330 (Genetics & Physiology);

Having had or currently enrolled in CHEM 471 (Biochemistry I) strongly suggested.

Text: Molecular Biology of the Cell, 4th edition, Alberts et al.

Molecular Biology of the Cell: A Problems Approach, companion to Alberts et al.

Date Topic Chapter

Tu 1/17 Organization and Introduction

Th 1/19 Cells and Genomes 1

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Tu 1/24 Proteins 3

• Structure of proteins

Th 1/26 Proteins 3

• Protein function

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Tu 1/31 DNA and chromosomes 4

• Structure and function of DNA

Th 2/2 DNA and chromosomes 4

• Chromosomes - packaging of DNA

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Tu 2/7 How Cells Read the Genome 6

• From DNA to RNA

Th 2/9 How Cells Read the Genome 6

• From RNA to Protein

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Tu 2/14 Exam #1

Th 2/16 Control of Gene Expression 7

• An overview of gene control

• DNA-binding motifs in gene regulatory proteins

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Tu 2/21 Control of Gene Expression 7

• How genetic switches work

Th 2/23 Control of Gene Expression 7

• Creating specialized cell types

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Tu 2/28 Membrane Structure 10

Th 3/2 Membrane Transport 11

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Tu 3/7 Membrane Transport 11

Th 3/9 Exam #2

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March 14, 16 Spring Break

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Tu 3/21 Cytoskeleton 16

• Structure of cytoskeletal filaments

Th 3/23 Cytoskeleton 16

• Molecular motors

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Tu 3/28 Intracellular Compartments and Protein Sorting 12

• Compartments

• Transport of molecules between compartments

Th 3/30 No Class – ENJOY! STUDY!

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Tu 4/4 Intracellular Compartments and Protein Sorting 12

• Endoplasmic reticulum

Th 4/6 Intracellular Vesicular Traffic 13

• Transport through the endomembrane system

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Tu 4/11 Intracellular Vesicular Traffic 13

• Endo- and exocytosis

Th 4/13 Exam #3

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Tu 4/18 Cell Communication 15

• General principles

Th 4/20 Cell Communication 15

• G-protein coupled receptor

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Tu 4/25 Cell Communication 15

• Enzyme-linked cell-surface receptors

Th 4/27 Cell Cycle 17

• Overview

• Components of cell-cycle control system

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Tu 5/2 Cell Cycle 17

• Intracellular control of cell-cycle events

Th 5/4 DNA replication 5

• Mechanisms

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May 10 FINAL EXAM 8:00 AM

Class Policy: Attendance is required. Do not miss lecture. Do not miss labs. Attendance and participation in the lab is mandatory. Missed labs cannot be made up and will result in a score of 0 for that week’s assignment. Late lab assignments (reports, write-ups) will be granted half credit only.

Grades: There will be four exams. The fourth exam will be administered during finals week, but will not be cumulative. There will also be 4 pop quizzes. The average of pop quizzes these will be counted as an additional exam grade. Exams will account for 70% of the course grade. Laboratory participation, paper discussions, analysis questions, and write-ups will account for 30% of the grade.

Make up exams: Students can make up exams immediately after the final exam if they have documentation regarding their absence (i.e. doctor’s note, court date, death certificate). Missed pop quizzes cannot be made up.

Grading Scale: A: 90-100; B: 80-89; C: 70-79; D: 60-69; F: 59 or below

This syllabus is subject to change at the discretion of the instructor to accommodate instructional, and/or student needs.

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