AP Biology 2020 Practice Exam and Notes #2
The p53 protein is a transcription factor that regulates a cell’s progression through the cell cycle after DNA is damaged by ultraviolet (UV) radiation. The p53 pathway is shown in Figure 1.Figure 1. The role of p53 in regulating cell cycle progression in response to DNA damageA skin cell completes one round of the cell cycle. Describe the products.Based on Figure 1, explain how p53 regulates the cell cycle in the presence of damaged DNA.Draw an X on the template in the space provided for your response to indicate the phase during which the replication of damaged DNA would occur.Based on Figure 1, explain how a mutation to p53 may lead to an increased risk of cancer. ................
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