Marc Three - CV
CURRICULUM VITAE
Personal Data
Name: Marc Peters-Golden, M.D.
Education and Training
1967-70 Pennsauken High School, Pennsauken, New Jersey
1970-74 Franklin and Marshall College, Lancaster, Pennsylvania; A.B. magna cum laude, honors in biology and special studies
1974-78 Duke University School of Medicine, Durham, North Carolina; M.D.
1978-81 Resident, Internal Medicine, Tufts-New England Medical Center, Boston, Massachusetts
1981-83 Research Fellow, Pulmonary Medicine and Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland
1983-84 Clinical Fellow, Pulmonary Medicine, The Johns Hopkins University, Baltimore, Maryland
Certification and Licensure
1984 Medical Licensure, Michigan (No. 47562)
1981 Certification, American Board of Internal Medicine
1984 Certification, Subspecialty in Pulmonary Diseases
1988-97 Certification, Subspecialty in Critical Care Medicine
Academic, Administrative, and Clinical Appointments
1984-91 Assistant Professor of Internal Medicine, The University of Michigan, Ann Arbor
1984-95 Staff Physician, Department of Veterans’ Affairs Medical Center, Ann Arbor
1984- Staff Physician, University of Michigan Health System, Ann Arbor
1991-96 Associate Professor of Internal Medicine with tenure, The University of Michigan, Ann Arbor
1996- Professor of Internal Medicine with tenure, The University of Michigan, Ann Arbor
2002- Faculty Member, Graduate Program in Immunology, University of Michigan Medical School
1996-2011 Fellowship Program Director, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan
2011- Associate Fellowship Program Director for Research, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan
Consulting Positions
1992 External Advisory Committee, NIH Program Project Grant, "Lipid Mediators and Lung Injury," D.A. Bass, Principal Investigator, Bowman-Gray School of Medicine, Winston-Salem, N.C.
1996 Zeneca Pharmaceuticals, Abbott Laboratories
1996 External Examiner, Faculty of Graduate Studies and Research, McGill University
1997- Merck and Company, Inc.
1999. Monsanto Company
2001 Millennium Pharmaceuticals, Inc.
2002. Scientific and Clinical Advisory Boards, Virocell, Inc.
2003 Gerson Lehrman Group’s Council of Healthcare Advisors
2004 External Examiner, School of Graduate Studies, McMaster University
2004 Forest Laboratories, Inc.
2004 Advisory Board, University of Tennessee NIEHS Superfund Basic Research Proposal
2004-2008 Critical Therapeutics, Inc.
2004 LTB4 Sweden AB
2004 Pfizer, Inc.
2006 Efficas, Inc.
2006- External Advisory Committee, NIH Program Project Grant, “Ether lipids, eicosanoids, and lung cell pathophysiology,” C.C. Leslie, Principal Investigator, National Jewish Medical and Research Center
2007-2011 Adult Respiratory Advisory Board, Merck and Company, Inc.
2007-2008 Eli Lilly and Company
2007 DeCODE Genetics, Inc.
2008- Nycomed/Takeda
2008- External Advisory Board, Virginia Commonwealth University School of Medicine, training grant on “Lipid Signaling and Functional Lipidomics in Cardiovascular and Respiratory Diseases (LCRD)”
2008 Actelion Pharmaceuticals
2009 Boehringer Ingelheim
2009 Ono Pharmaceuticals
2010 Sanofi-Aventis
2011 Glaxo SmithKline
Scientific Activities
Grant Review Activities:
1986-90 Member, American Lung Association/American Thoracic Society Research Review Committee
1988 Ad hoc reviewer, Veterans Administration Career Development Program
1988-94 Ad hoc reviewer, Veterans Administration Merit Review (Respiratory)
1993 Ad hoc reviewer, The Israel Science Foundation
1993 Member, Special Review Committee for RFA 92-04 ("Ozone: mechanisms of action"), National Institute of Environmental Health Sciences/National Heart Lung and Blood Institute
1993 Ad hoc reviewer, The Health Effects Institute, Cambridge, MA
1993 Ad hoc reviewer, American Federation for Clinical Research Foundation Early Career Development Award
1995 Member, Site Visit and Special Emphasis Panel, "Research Center for Pharmacology and Drug Toxicology,” Vanderbilt University; National Institutes of General Medical Science
1996 Member, American Lung Association Asthma Research Center Review Committee
1996 Ad hoc reviewer, Alberta Lung Association
1996 Ad hoc reviewer, NATO Advanced Study Institutes
1997 Ad hoc reviewer, The Wellcome Trust
1999. Member, Special Emphasis Panel, Asthma and Allergic Diseases Research Centers, National Institute of Allergy and Infectious Disease
2000. Member, Special Emphasis Panel, Program Project on “Inflammation, Airways Reactivity, and Asthma,” National Jewish Medical and Research Center; National Heart, Lung, and Blood Institute
2001. Ad hoc reviewer, Arthritis Research Campaign, United Kingdom
2002. Member, Special Emphasis Panel, Respiratory Physiology Ad Hoc Study Section, National Heart Lung and Blood Institute
2003. Member, Special Emphasis Panel, Program Project on “Activation and Organization of Stress Signaling,” Massachusetts General Hospital; National Institute of General Medical Sciences
2003 Ad hoc reviewer, Jeffress Research Grant Program, Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust
2003 Ad hoc reviewer, British Lung Foundation
2004 Study Section Consultant, Oak Ridge Associated Universities/Pennsylvania Department of Health Lung Research Initiative
2004 Ad hoc reviewer, British Lung Foundation
2004, 2005 Member, Special Review Committee, Program Project on “Chemical Mediators of Acute Pulmonary Disorders,” Brigham and Women’s Hospital; National Heart, Lung, and Blood Institute
2005 Ad hoc reviewer, Marsden Fund, New Zealand
2005 Ad hoc reviewer, The Israel Science Foundation
2006 Member, Special Emphasis Panel, Competing Renewal for Severe Asthma Research Program, National Heart Lung and Blood Institute
2006 Ad hoc reviewer, British Lung Foundation
2007 Ad hoc reviewer, Health Research Board of Ireland
2009 Ad hoc reviewer, British Lung Foundation
2009 Member, Special Emphasis Panel, Program Project on “Impact of Infection in Resolution Circuits of Inflammation,” Brigham and Women’s Hospital; National Institute of Allergy and Infectious Diseases
2009 Ad hoc reviewer, Austrian Academy of Sciences doctoral fellowships
2009 Member, Special Emphasis Panel to review conflict applications from NHLBI study section members
2009 Ad hoc reviewer, Asthma Foundation of Western Australia
2010 Ad hoc reviewer, Alberta Heritage Foundation for Medical Research
2010 Ad hoc reviewer, Austrian Science Fund research grants
2010 Ad hoc reviewer, The Wellcome Trust/DBT India Alliance
2011 Ad hoc reviewer, Discovery Grants program, Natural Sciences and Engineering Research Council of Canada
2011 Member, Special Emphasis Panel to review applications for RFA “Counter Measures Against Chemical Threats”
2011 Ad hoc reviewer, United Kingdom Medical Research Council Career Development Awards
2011, 2012 Ad hoc reviewer, Program for Scientific Research in Biomedicine, Fondazione Cariplo, Milan, Italy
2013 Member, Review Committee for RFA “Phase II Clinical Trials of Novel Therapies for Lung Diseases”
Editorial Positions:
1992-00 Member, Editorial Board, American Journal of Physiology: Lung Cellular and Molecular Physiology
1996-02 Member, Primary Review Pool, Journal of Immunology
2002-06 Section Editor, Journal of Immunology
2002-08 Section Editor, Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids)
2007- Member, Editorial Board, Clinical and Translational Science
2010- Member, Editorial Board, Thorax
Conference Organization
2001 Co-organizer, Keystone Symposium on Lipid Mediators, Snowbird, UT
Reviewer for Scientific Journals:
American Journal of Pathology
American Journal of Physiology: Cell Physiology
American Journal of Physiology: Lung Cellular and Molecular Physiology
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory Cell and Molecular Biology
American Journal of Veterinary Research
Apoptosis
Biochemical Journal
Biochemistry and Cell Biology
Biochimica et Biophysica Acta
Blood
British Journal of Pharmacology
Chest
Circulation Research
Clinical and Experimental Allergy
Clinical Immunology and Immunopathology
Current Drug Targets – Inflammation and Allergy
European Respiratory Journal
European Journal of Immunology
Experimental Lung Research
FASEB Journal
Infection and Immunity
Journal of Allergy and Clinical Immunology
Journal of Applied Physiology
Journal of Biological Chemistry
Journal of Clinical Investigation
Journal of Experimental Medicine
Journal of Immunology
Journal of Laboratory and Clinical Medicine
Journal of Leukocyte Biology
Journal of the National Cancer Institute
Journal of Pharmacology and Experimental Therapeutics
Laboratory Investigation
Life Sciences
Mediators of Inflammation
Medicinal Chemistry Reviews
Metabolism
Nature
Proceedings of the American Thoracic Society
Proceedings of the National Academy of Sciences
Prostaglandins
Respiration
Respiratory Research
Sarcoidosis, Vasculitis and Diffuse Lung Diseases
Science
Science Signaling
Science Translational Medicine
Thorax
Translational Research
Trends in Biochemical Sciences
Trends in Immunology
Grant Support
Current:
NIH P50 P50HL107177
“Prostanoids, Plasminogen Activation, and Personalized Therapeutics in IPF”
Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases
(CADET)
4/1/11-3/31/13; Principal Investigator, 10% effort
$300,000 annual direct costs
NIH R01 HL58897
“Eicosanoids and Lung Macrophage Antimicrobial Mechanisms”
8/1/09-7/31/13; Principal Investigator, 30% effort
$250,000 annual direct costs
NIH R01 HL 94311
“Control of Fibroblast Function by Prostaglandin E2 and Plasminogen Activation”
8/10/09-8/09/13; Principal Investigator, 30% effort
$250,000 annual direct costs
NIH T32 HL00749
“Multidisciplinary Training Program in Lung Disease”
7/1/08-6/30/13; Associate Director, 5% effort; Theodore Standiford, Director
$730,364 annual direct costs
NIH R01 HL094622
“Role of Resident Mesenchymal Stem Cells in Lung Allograft Rejection”
8/1/09-5/31/14; Co-Investigator, 5% effort; Principal Investigator, Vibha Lama
$250,000 annual direct costs
NIH R01 HD057176
“Role of Misoprostol in Clostridium Sordellii Endometritis after Medical Abortion”
9/1/08-5/31/13; Co-Investigator, 5% effort; Principal Investigator, David Aronoff
$201,960 annual direct costs
NIH 1 K08 HL094657
“Epigenetic Regulation of the E Prostanoid 2 Receptor Gene in Lung Fibroblasts”
7/1/09-6/30/14; Sponsor for Steven Huang, M.D.
$125,000 annual direct costs
American Lung Association
“Inhibition of Phagocyte Oxidase in Alveolar Macrophages by Prostaglandin E2”
7/1/11 - 6/30/13; Sponsor for Emilie Bourdonnay, Ph.D.
$32,500 annual direct costs
American Lung Association
“Role of Eicosanoids in Macrophage Accumulation and Polarization in Allergic Asthma”
7/1/12 - 6/30/14; Sponsor for Zbigniew Zaslona, Ph.D.
$32,500 annual direct costs
Recent:
NIH 1 K99 HL103777
“Regulation of Toll-Like Receptor-Induced NFκB Activation by Gαi-Coupled Receptors”
8/1/10-7/30/12; Sponsor for Carlos Henrique Serezani, Ph.D.
$707,669 total direct costs
NIH R01 AI 065543
“PGE2 Regulation of Host Defense post BMT”
05/15/07-04/30/12, Co-Investigator, 5% effort, Principal Investigator Bethany Moore
$250,000 annual direct costs
NIH R01 HL087846
“Herpesvirus Infections Recruit Fibrocytes and Augment Pulmonary Fibrosis”
3/1/08-2/28/12, Co-Investigator, 5% effort (.60 calendar months), Principal Investigator, Galen Toews
$250,000 direct costs annually
American Lung Association
“Protein Kinase A Signaling is Impaired in Fibrotic Lung Fibroblasts and Rescued by Plasminogen Activation”
7/1/10 - 6/30/12; Sponsor for Katsuhide Okunishi, M.D., Ph.D.
$32,500 annual direct costs
NIH R01 HL085149
“Eicosanoid Balance in Lung Transplant Injury and Repair”
9/1/06–8/31/11, Co-Investigator, 5% Effort, Principal Investigator, David Pinsky
$250,000 annual direct costs
American Heart Association Cardiovascular Medical Research and Education Fund
Idiopathic Pulmonary Arterial Hypertension Center for Cell Studies
“Vascular Cell Contribution to Plexogenic Pulmonary Arteriopathy in Pulmonary Arterial Hypertension”
4/1/06-3/30/11; Co-Investigator, 5% effort; Principal Investigator, David Pinsky
$250,000 annual direct costs
NIH R01 GM068848-05
“Catalysis by Prostaglandin Endoperoxide H Synthases”
9/01/07 - 8/31/11, Co-Investigator, 5% effort; Principal Investigator, William W. Smith
$290,611 annual direct costs
NIH R01 HL077417
“Regulation of Pulmonary Host Defense by Leptin”
12/1/05-11/30/10; Co-Investigator, 5% effort; Principal Investigator, Peter Mancuso
$200,000 annual direct costs
NIH U10 HL080371 (Idiopathic Pulmonary Fibrosis Clinical Research Network)
“Novel Therapeutic Approaches in IPF”
5/1/05-4/30/10; Co-Investigator on Clinical Core, 5% effort (Principal Investigator, Fernando J. Martinez); Co-Investigator on Clinical Skills Development Core, 5% effort (Principal Investigator, Galen Toews)
$550,000 annual direct costs
NIH UL1 RR024986
“Michigan Institute for Clinical and Health Research”
9/17/07-6/30/10 Participating Investigator, 5% effort, Principal Investigator, Kenneth Pienta
$5,712,296, annual direct costs
NIH 1 K08 HL078727
Modulation of Lung Innate Immunity by Prostaglandin E2”
12/1/04-11/30/09; Sponsor for David Aronoff, M.D.
$122,500 annual direct costs
NIH 1 K23 HL077719
“Fibroproliferation in Bronchiolitis Obliterans”
7/1/04-6/30/09; Co-Sponsor for Vibha Lama, M.D.
$125,000 annual direct costs
Hartwell Foundation Fellowship Grant
“The Role of prostaglandin E2 in mediating intracellular signaling pathways in neonatal alveolar macrophages”
1/1/08 - 12/31/09; Sponsor for Megan Ballinger
$50,000 annual direct costs
American Lung Association, RT-78960-N
“Modulation of Alveolar Macrophage Antimicrobial Functions by Eicosanoids: Role of Lipid Rafts and Signaling Molecules”
7/1/08 - 6/30/09; Sponsor for C. Henrique Serezani
$32,500 annual direct costs
Parker B. Francis Fellowship, Francis Families Foundation
“Epigenetic Regulation of the E Prostanoid 2 Receptor Gene in Fibrotic Lung Fibroblasts”
Period: 7/1/08 - 6/30/09; Sponsor for Steven Huang
$50,000 annual direct costs
Certification and Licensure
1984 Medical Licensure, Michigan (No. 47562)
1981 Certification, American Board of Internal Medicine
1984 Certification, Subspecialty in Pulmonary Diseases
1988-97 Certification, Subspecialty in Critical Care Medicine
Honors and Awards
1974 Phi Beta Kappa
1974 Rawnsley Science Prize (student most likely to apply scientific knowledge to benefit of community)
1974 Williamson Medal (awarded by faculty vote to one graduating senior for excellence in scholarship, leadership and character)
1980. Outstanding Housestaff Teaching Award from students of Tufts Medical School
1983-84 Fellow of The American Lung Association of Maryland
1990, 1991 Henry Christian Award for scientific excellence in research, American Federation for Clinical Research national meeting
1990-95 Career Investigator Award, American Lung Association
1996 American Society for Clinical Investigation (elected)
1996. American Lung Association of Michigan Board Member of the Year
2003 Association of American Physicians (elected)
2006 Inaugural Outstanding Faculty Award conferred by Pulmonary and Critical Care Medicine Fellows, University of Michigan Medical Center
2007 Recognition Award for Scientific Accomplishment, American Thoracic Society
2011 University of Michigan Medical School League of Research Excellence
2011, 2013 Best Doctors in America, Pulmonary Medicine
2013 The Harold and Marilyn Menkes Memorial Lecturer, Johns Hopkins University Bloomberg School of Public Health
Memberships and Offices in Professional Societies
1983- American Thoracic Society
1985- American Federation for Medical Research
1985- Michigan Thoracic Society; 1991-93, Secretary-Treasurer; 1993-95, Vice President; 1995-97, President
1989- Central Society for Clinical Research
1990- American Association for the Advancement of Science
1992- American Association of Immunologists
Teaching, University of Michigan
Supervision of Internal Medicine House Officers in Senior Research Projects: Nathalie Brophy, M.D. (1986), Jussi Saukkonen, M.D. (1988), S. Patrick Nana-Sinkam, M. D. (1998), Derek Dimcheff, M.D., Ph.D. (2012)
Graduate Thesis Committees: Megan Ballinger (Immunology, Ph.D. conferred 2007); Kevin Vanella (Immunology, Ph.D. conferred 2009), Ben Cronin (Immunology, Ph.D. conferred 2010), Deepti Nagarkar (Molecular and Integrative Physiology, Ph.D. conferred 2010)
Laboratory Trainees
Trainee (Dates) Training Award Current Position
James Chauncey, MD National ALA Research Grant Private Practice
(1985-87)
Peter Sporn, MD National ALA Research Fellow Professor &
87) Trudeau Scholar of the National Director of Fellowship Program
ALA Pulmonary Division
Clinical Investigator Award, NIH Northwestern University
Meyer Balter, MD National ALA Research Fellow Professor
(1986-88) Ontario Lung Association Grant Pulmonary Division
University of Toronto
Randolph Lipchik, MD ALA of Michigan Research Fellow Professor
90) National Research Service Pulmonary Division
Award, NIH Medical College of
Wisconsin
Peter Gray, DVM, PhD Graduate Student Fellowship Research Fellow
(1989-90) Michigan State University University of Western
Australia
Gregory Neagos, MD National ALA Research Fellow Private Practice
(1990-92)
Michael Coffey, MD Clinical Investigator Award, NIH Associate Professor
(1990-93) Pulmonary Division
University of Michigan
Jerome Wilborn, MD ACCP Boehringer Ingelheim Fellow Private Practice
(1991-94) NIH Minority Supplement Trainee
Randall Covin, MD National ALA Research Fellow Private Practice
(1992-96)
Thomas Brock, PhD NIH Postdoctoral Training Grant Scientist
(1993-96) Parker B. Francis Research Cayman Chemical
Fellowship Ann Arbor, MI
Tammy C. Ojo, MD ALA of Michigan Research Fellow Assistant Professor
(1994-95) Pulmonary Division
University of Michigan
Patricia Tithof, DVM PhD Postdoctoral Fellowship Associate Professor
(1994-95) Michigan State University University of Tennessee
College of Veterinary Medicine
Marc Bailie, DVM, PhD NIH Postdoctoral Training Grant Associate Professor
(1994-96) Pharmacology and Toxicology
Michigan State University
Peter Mancuso, PhD NIH Postdoctoral Training Grant Associate Professor
(1997-99) ALA of Michigan Research Fellow Environmental Health Sciences
School of Public Health
University of Michigan
Marc Jacobs, MD None Private Practice
(1998-99)
Vibha Lama, MD None Associate Professor
(2000-01) Pulmonary Division
University of Michigan
Claudio Cannetti, Ph.D. CNPq Fellowship, Brazil Assistant Professor
(2002-04) Biophysics Department
State University of Rio de Janeiro
Rio de Janeiro, Brazil
David Aronoff, M.D. NIH Postdoctoral Training Grant Associate Professor
(2002-04) Parker B. Francis Fellowship Infectious Disease Division
University of Michigan
Ryan Charbeneau, M.D. GlaxoSmithKline Pulmonary Private Practice
(2003-04) Fellowship Award
Carlos Henrique Serezani, Ph.D. Brazilian Research Foundation Ph.D. Student
(2003-04) Department of Immunology
University of Sao Paulo
(2006-12) American Lung Association Senior Assistant Professor
Research Training Fellowship Department of Microbiology and Immunology
NIH K99/R01 Indiana University
Steven Huang, M.D. NIH Postdoctoral Training Grant Assistant Professor
(2005-07) ATS Career Development Award Pulmonary Division
Parker B. Francis Fellowship University of Michigan
Camila Peres Brazilian Research Foundation Research Investigator
(2005-06) Dental School
University of Sao Paulo-Bauru
Jooho Chung (2006-07) none MSTP Student
University of Michigan
Megan Ballinger, Ph.D. NIH Postdoctoral Training Grant Lecturer
(2007-09) Hartwell Foundation Pulmonary Division
University of Michigan
Sang Pyo Lee, M.D. Gachon Univ. School of Medicine Associate Professor
(2007-08) Seoul, South Korea Pulmonary Division
Gachon University
Seoul, South Korea
Alexandra Medeiros, Ph.D. CNPq Fellowship, Brazil Assistant Professor
(2007-09) Department of Immunology
Federal University of Sao Paulo, Araraquara, Brazil
Anna Kovalszki, M.D. none Assistant Professor
(2007-08) Allergy Division
Harvard University
Katsuhide Okunishi, M.D., Ph.D. Uehara Memorial Foundation Associate Professor
(2008-12) American Lung Association Gumma University, Japan
Sang-Hoon Kim, M.D. Eulji Univ. School of Medicine Associate Professor
(2009-10) Seoul, South Korea Pulmonary Division
Eulji University School of Medicine
Seoul, South Korea
Camila Stumm Brazilian Research Foundation Medical Science Liaison
(2009-10) Novartis
Brazil
Emilie Bourdonnay, Ph.D. American Lung Association Postdoctoral Research Fellow
(2009-) Pulmonary Division
University of Michigan
Garth Garrison, M.D. Assistant Professor
(2009-11) Pulmonary Division
University of Vermont
Zbigniew Zaslona, Ph.D. German Research Foundation Postdoctoral Research Fellow
(2010- ) American Lung Association Pulmonary Division
University of Michigan
Jacob Scott, M.D. Pulmonary Fellow
(2011- ) University of Michigan
Derek Dimcheff, M.D., Ph.D. Internal Medicine Resident
(2012- ) University of Michigan
Raghu Kumar, Ph.D. Postdoctoral Research Fellow
(2012- ) University of Michigan
Extramural Invited Presentations
Invited Speaker at Scientific Meetings
05/90 "Role of arachidonic acid metabolites in airway hyperreactivity," American Thoracic Society Meeting, Boston, MA
11/90 "Corticosteroid therapy in asthma -- a critical review with regard to controversies," Connecticut State Chest Conference, Yale University, New Haven, CT
05/91 "Molecular regulation of arachidonate metabolism," American Thoracic Society Meeting, Anaheim, CA
09/91 "Eicosanoids in the pathogenesis of asthma: perspective and pitfalls," National Meeting of the Comparative Respiratory Society, East Lansing, MI:
01/92 "Novel aspects of 5-lipoxygenase regulation in alveolar macrophages,” 1992 Winter Prostaglandin Conference, Keystone, CO
10/92 "Future trends in asthma therapy: the research perspective," American Lung Association of Michigan Conference on The New NIH Guidelines on Asthma, Traverse City, MI
10/93 "Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction of activated macrophages," International Congress on Inflammation, Vienna, Austria
03/94 "Expression and regulation of PLA2s in lung cells," Pulmonary Research Group/Inflammation Research Association-sponsored conference on "Phospholipases and pulmonary function," New York Academy of Sciences
05/94 "The dawning of the nuclear era: the new cell biology of eicosanoid synthesis and action," American Thoracic Society Meeting, Boston, MA
06/94 "Localization of 5-lipoxygenase to the nucleus of resting rat basophilic leukemia cells, " Ninth International Conference on Prostaglandins and Related Compounds, Florence, Italy
04/95 "Intracellular localization of 5-lipoxygenase: implications for enzyme function," Symposium on Lipid Mediators, FASEB meeting, Atlanta, GA
05/96 "Intracellular localization of eicosanoid-forming enzymes: insights and questions," Fourth International Symposium of Jagiellonian Medical Research Centre, Cracow, Poland
05/96 “Inflammatory mechanisms in the lung,” American Thoracic Society Meeting, New Orleans, LA
06/96 “Intracellular localization of 5-lipoxygenase: surprising implications for the cell biology of eicosanoid synthesis and action,” American Society for Biochemistry and Molecular Biology Meeting, New Orleans, LA
05/97 “The intersection of lipid and polypeptide mediators: from strangers to bedfellows,” American Thoracic Society Meeting, San Francisco, CA
06/97 “Molecular mechanisms of leukotriene synthesis: the evolving paradigm,” William Harvey Research Conference, London, England
06/97 “The nucleus as the intracellular site for 5-lipoxygenase localization and action,” Gordon Research Conference on Lipid Metabolism, Kimball Union Academy, Meriden, NH
09/97 “Anti-leukotriene agents: a new option in asthma therapy,” Michigan Association of Respiratory Care Annual Meeting, Frankenmuth, MI
01/98 “Role of anti-leukotriene agents in the treatment of asthma,” Minnesota Thoracic Society Meeting, St. Paul, MN
04/98 “Alveolar macrophages as mediators of inflammatory lung disease,” Postgraduate course, American Thoracic Society Meeting, Chicago, IL
09/98 “Cell biology of 5-lipoxygenase,” Asthma Club of Sendai Conference, Sendai, Japan
09/98 “Anti-leukotriene drugs for asthma,” Kyoto Asthma Forum, Kyoto, Japan
10/98 “Utility of anti-leukotriene agents in the treatment of asthma,” Indiana Thoracic Society Meeting, Indianapolis, IN
11/98 “Intracellular compartmentalization of leukotriene biosynthesis,” Symposium on “Leukotrienes as Targets for Treatment of Asthma and Other Diseases: Current Basic and Clinical Research,” Karolinska Institute, Stockholm Sweden
12/98 “Role of leukotriene receptor antagonists in adult asthmatics: where does it fit into asthma treatment guidelines?” Hong Kong Allergy Convention, Hong Kong
04/99 “Nuclear trafficking of enzymes associated with eicosanoid biosynthesis,” Keystone Symposium Keystone, CO
04/99 “New insights into leukotriene synthesis: the inside story,” American Thoracic Society Meeting, San Diego, CA
06/99 “Novel perspectives on leukotriene biology,” 4th World Congress on Inflammation, Paris, France
07/99 “Inhaled steroids: how much is enough?” Annual Congress of the Malaysian Thoracic Society, Kuala Lumpur
08/99 “COX-2 and the lung: perpetrator or protector?” Third International Workshop on COX-2, Kona, Hawaii
10/99 “Positioning anti-leukotriene agents in asthma treatment: insights from the perspective of eicosanoid biology,” Colorado Asthma and Allergy Society, Denver, CO
03/00 “Use of montelukast as a primary controller agent in the treatment of asthma,” Asthma Symposia, Taipei, Kaoshiung, and Taichung, Taiwan
04/00 “Evolving role of leukotriene receptor antagonists in the management of asthma,” Asthma Symposia, Guangzhou, Shanghai, and Beijing, China
04/00 “Asthma controller therapy: insights from the perspective of eicosanoid biology.” Puget Sound Allergy and Asthma Society, Seattle, WA
04/00 “Anti-leukotriene agents in asthma management; what have we learned and what must we learn?” Michigan Thoracic Society Annual Meeting, Novi, MI
05/00 “Lipid mediators,” American Thoracic Society/National Institute of Environmental Health Sciences Workshop, Toronto, Canada
05/00 “Natural knockouts: acquired eicosanoid deficiencies and susceptibility to lung disease,” American Thoracic Society Meeting, Toronto Canada
06/00 “5-Lipoxygenase and the nucleus: where, when, how, and why?” 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, Florence, Italy
08/00 “Role of the 5-lipoxygenase pathway in the antimicrobial activity of phagocytes,” FASEB Research Conference, Saxtons River, VT
10/00 "Regulation of leukotriene synthesis" and "Role of leukotrienes in diseases other than asthma," Merck Air Board Workshop, Hayman Island, Australia
03/01 “New insights into the role of leukotrienes in asthma,” Toronto City-Wide Allergy and Immunology Society, Toronto, Ontario
04/01 “Leukotrienes and antimicrobial defenses,” Keystone Symposium, Snowbird, UT
05/01 “Lipid mediators and the inflammatory process,” American Thoracic Society Meeting, San Francisco, CA
05/01 “Leukotrienes in the pathogenesis of interstitial lung disease,” American Thoracic Society Meeting, San Francisco, CA
05/01 “Research year in review: Allergy, immunology, and inflammation assembly,” American Thoracic Society Meeting, San Francisco, CA
05/01 “What is the anti-inflammatory role of leukotriene modifiers in chronic asthma?” American Thoracic Society Meeting, San Francisco, CA
08/01 “Eicosanoids in asthma and allergic disease: a bench to bedside perspective,” Annual Meeting of the California Society of Allergy, Asthma, and Immunology, Squaw Valley, CA
10/01 “An imbalance between leukotrienes and prostaglandin E2 is a central feature of fibrotic lung disease,” Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases, 7th International Conference, Nashville, TN
10/01 “Importance of leukotrienes in airway inflammation and remodeling,” Singulair Second Anniversary Symposium, Lisbon, Portugal
03/02 “State of the science: biologic actions of leukotrienes in asthma, atopic disease, and airway remodeling,” 12th Congress of Interasthma Japan/North Asia, Saitama, Japan
04/02 “Leukotrienes in asthma and allergic disease: the view from 2002,” Buffalo Allergy Society, Buffalo, NY
05/02 “An imbalance between leukotrienes and prostaglandin E2 is a central feature of fibrotic lung disease,” American Thoracic Society Meeting, Atlanta, GA
05/02 “Studying the mediator and inflammatory mechanisms of leukotrienes,” American Thoracic Society Meeting, Atlanta, GA
05/02 “Lipid mediators,” American Thoracic Society Meeting, Atlanta, GA
08/02 “New insights into leukotriene synthesis and action: the view from 2002,” Plenary Lecture, Annual Meeting of the Brazilian Federation of the Societies for Experimental Biology, Salvador, Brazil
10/02 “Inhibition of transforming growth factor-β-induced myofibroblast differentiation by prostaglandin E2,” Twelfth International Colloquium on Lung Fibrosis, Glion, Switzerland
12/02 “New perspectives on the biology of leukotrienes,” San Diego Allergy Society, San Diego, CA
03/03 “Therapeutic targeting in a complex inflammatory milieu,” American Academy of Allergy Asthma & Immunology Meeting, Denver, CO
05/03 “Beyond bronchospasm: eicosanoids as mediators of innate and adaptive immune responses,” American Thoracic Society Meeting, Seattle, WA
09/03 “Eicosanoids: master modulators of innate immune responses,” 8th International Meeting on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases, Chicago, IL
05/04 “Beyond blueprints and roadmaps: a clinician-scientist’s 3-dimensional view of integrative biomedical research and training,” Joint Medical Research Council/Wellcome Trust Workshop on Integrative Physiology, London, England
10/04 “Leukotrienes: multifunctional mediators of asthma and allergic diseases,” Biannual Meeting of the Philadelphia Allergy Society, Philadelphia, PA
05/05 “Leukotriene modifiers: mediators, mechanisms, remodeling, and more,” American Thoracic Society Meeting, San Diego, CA
10/05 “Leukotrienes and the lung: a decade of insights,” Keynote Address, scientific forum sponsored by Ono Pharmaceuticals to celebrate 10th anniversary of launch of pranlukast, the world’s first leukotriene modifier drug for asthma; Tokyo, Japan
11/05 “Leukotrienes in 2005: emerging science,” American College of Chest Physicians Meeting, Montreal, Quebec, Canada
01/06 “Eicosanoids in pulmonary fibrosis: a tale of two lipids,” plenary speaker, Keystone Symposium, Park City, UT
03/06 “Eicosanoids and pulmonary fibrosis,” American Academy of Allergy Asthma & Immunology Meeting, Miami, FL
07/06 “Eicosanoid biology and respiratory disease,” The University of Michigan John A. Sheldon Allergy Society Triannual Meeting, Boyne Mountain, MI
03/07 “Eicosanoids in inflammation: themes, opportunities, and challenges,” Ninth Annual Winter Eicosanoid Conference, Baltimore, MD
05/07 “Insights from eicosanoid deficiency states: a tale of two lipids,” Recognition for Scientific Accomplishment Award Lecture, American Thoracic Society Meeting, San Francisco, CA
06/07 “Eicosanoids and airway remodeling,” 26th Congress of the European Academy of Allergology and Clinical Immunology, Göteborg, Sweden
11/07 “Understanding responsiveness to leukotriene modifiers,” International Asthma Forum, Barcelona, Spain
02/08 “Eicosanoids in fibroproliferative lung disease: a tale of two lipids,” 11th Annual Meakins-Christie Workshop, Asthma and COPD, Orford-Magog, Quebec, Canada
04/08 “Anti-leukotriene drugs in asthma,” Allergy, Asthma, and Immunology Society of Ontario Annual Meeting, Toronto, Ontario, Canada
05/08 “Unique traits of lung macrophages in obesity: leptin, leukotrienes, and lots more,” Workshop on Obesity and Asthma, American Thoracic Society Meeting, Toronto, Ontario, Canada
06/08 “Understanding responsiveness to leukotriene modifiers in asthma,” Spanish National Congress of Pneumology Annual Meeting, Tenerife, Spain
07/08 “Leukotrienes in lung innate immunity,” IXth World Conference on Clinical Pharmacology and Therapeutics CPT 2008, Quebec City, Quebec, Canada
09/08 “Eicosanoid balance: A critical determinant of innate immune defense,” Highlight Symposium on Lipid Signaling, Joint Summer Retreat of the Graduate Schools of Frankfurt University and Karolinska University
10/08 “Leukotrienes: critical mediators of innate immunity and phagocyte function,” Brazilian Immunology Society Meeting, Ribeirao Preto, Brazil
11/08 “Eicosanoids as mediators of leukocyte innate immune function,” Meeting of the Society for Leukocyte Biology, Denver, CO
03/09 “Understanding responsiveness to leukotriene modifiers in asthma,” Asthma Debate II, Madrid, Spain
04/09 “Why do we have a 5-lipoxygenase pathway? Leukotrienes in innate immune cell activation,” Keystone Symposium on Complex Lipids, Lake Tahoe, CA
02/10 “Knocking your SOCS off: silencing of SOCS1 by leukotriene B4 is required for optimal macrophage MyD99 expression and NFκB activation,” Annual Meakins-Christie International Workshop, Bromont, Quebec, Canada
05/10 “Efferocytosis adversely affects lung anti-bacterial function,” American Thoracic Society Meeting, New Orleans, LA
05/10 “The immunology of the 5-lipoxygenase pathway,” Wenner-Gren Foundations International Symposium on Inflammation in Atherosclerosis: Activators & Mediators, Stockholm, Sweden
05/11 “Prostaglandin E2: anti-fibrotic mediator for all reasons,” American Thoracic Society Meeting, Denver, CO
10/11 “The PGE2 axis as a broken brake in lung fibrosis and a candidate for therapeutic targeting,” Brazilian Society of Immunology, Foz do Iguaco, Brazil
03/12 “Prostaglandin E2: unexpected regulator of airway remodeling and pulmonary host defense,” Airway Vista 2012, Asan Medical Center, Seoul, Korea
09/12 “Eicosanoid regulation of macrophage pattern recognition receptor responses,” Innate Immunity of the Lung, Berlin, Germany
12/12 “Dysregulation of the PGE2-EP2 axis in fibrotic lung disease,” British Pharmacological Society Meeting, London, UK
1/13 “Eicosanoid regulation of macrophage pattern recognition receptor responses,” Riken Center for Allergy and Immunology-University of Michigan Medical Center Joint Immunology Workshop, Ann Arbor, MI
| |
Invited Speaker at Other Institutions
02/88 Research Seminar, General Motors Research Laboratories, Warren, MI
03/90 Research Seminar, Pulmonary and Critical Care Medicine Division, Jefferson Medical College, Philadelphia, PA
06/90 Research Seminar, Department of Large Animal Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI
10/90 Research Seminar, Pediatric Pulmonary Section, Case Western University, Cleveland, OH
11/90 Research Seminar, Pulmonary and Critical Care Section, Yale University, New Haven, CT
04/91 Research Seminar, Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Quebec, Canada
02/92 Research Seminar, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI
12/93 Research Seminar, Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA
06/94 Research Seminar, Vanderbilt University Center for Lung Research, Nashville, TN
01/95 Research Seminar, National Institute of Environmental Health Sciences, Research Triangle Park, NC
10/95 Research Seminar, Division of Pulmonary and Critical Care, Temple University School of Medicine, Philadelphia, PA
10/95 Pulmonary Grand Rounds and Research Seminar, Temple University School of Medicine, Philadelphia, PA
10/96 Seminar, Michigan State University School of Veterinary Medicine, East Lansing, MI
12/96 Research Seminar, Zeneca Pharmaceuticals, Wilmington, DE
03/97 Grand Rounds, Beaumont Hospital, Royal Oak, MI
03/97 Pulmonary Grand Rounds, University of Pittsburgh Medical Center, Pittsburgh, PA
05/97 Seminar, Blue Cross Blue Shield of Michigan, Southfield, MI
05/97 Research Seminar, Division of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL
01/98 Medical Grand Rounds, Minneapolis VA Medical Center, Minneapolis, MN
03/98 Pulmonary/Allergy Grand Rounds, Detroit Medical Center, Detroit, MI
07/98 Pulmonary Research Conference, Northwestern University, Chicago, IL
09/98 Research Conference, Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan
09/98 Pulmonary Research Conference, Tohoku University, Sendai, Japan
10/98 Pulmonary Research Conference, Indiana University Medical Center, Indianapolis, IN
10/98 Pulmonary Research Conference, Henry Ford Hospital, Detroit, MI
10/98 Pulmonary Research Conference, Tufts-New England Medical Center, Boston, MA
01/99 Pulmonary Research Conference, University of Vermont, Burlington, VT
01/99 Medical Grand Rounds, University of Vermont, Burlington, VT
02/99 Internal Medicine Grand Rounds, Grace Hospital, Detroit, MI
04/99 Allergy Research Conference, University of Southern California, Los Angeles, CA
10/99 Research Seminar, National Jewish Center for Immunology and Respiratory Disease, Denver, CO
11/99 Research Seminar, Monsanto Company, St. Louis, MO
11/99 Research Seminar, University of Tennessee College of Veterinary Medicine, Knoxville, TN
12/99 Medical Grand Rounds, Medical College of Ohio, Toledo, OH
11/99 Pulmonary Medicine Conference, Mayo Clinic, Rochester, MN
05/00 Research Seminar, Meakins-Christie Research Laboratories, McGill University, Montreal, Quebec
05/00 Research Seminar, Inflammation and Rheumatology Research Center, Laval University, Sainte-Foy, Quebec
09/00 Pulmonary Grand Rounds, Cleveland Clinic Foundation, Cleveland, OH
09/00 Internal Medicine Grand Rounds, Metro Hospital, Cleveland, OH
09/00 Pulmonary Grand Rounds, Case Western Reserve University Hospital, Cleveland, OH
09/00 Pulmonary Research Conference, Rainbow Babies and Children's Hospital, Cleveland, OH
10/00 Research Seminar, Divisions of Allergy and Immunology and Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA
11/00 Pulmonary Research Conference, McMaster University, Hamilton, Ontario
01/01 Pulmonary Research Conference, Louisiana State University Medical Center, New Orleans, LA
01/01 Pulmonary Research Conference, Tulane University Medical Center, New Orleans, LA
01/01 Allergy and Immunology Research Conference, University of Texas Medical Branch, Galveston, TX
01/01 Internal Medicine Grand Rounds, Baylor Medical College, Houston, TX
02/01 Allergy and Immunology Research Conference, Children’s Hospital of Detroit, Detroit, MI
02/01 Asthma and Allergy Center Research Conference, Johns Hopkins University Medical Center, Baltimore, MD
02/01 Allergy and Immunology Research Conference, University of Virginia, Charlottesville, VA
03/01 Pulmonary Research Conference, Hospital of the University of Pennsylvania, Philadelphia, PA
03/01 Pulmonary Research Conference, Hahnemann-Medical College of Pennsylvania Hospitals, Philadelphia, PA
03/01 Pulmonary Grand Rounds, Jefferson Medical College, Philadelphia, PA
03/01 Respirology Research Conference, University of Toronto, Toronto, Ontario
05/01 Department of Medicine Noon Conference, Winthrop University Hospital, Mineola, NY
08/01 Medical Grand Rounds, Indiana University Medical Center, Indianapolis, IN
09/01 Pulmonary Grand Rounds, Ohio State University Medical Center, Columbus, OH
10/01 Combined Allergy/Pulmonary Research Seminar, University of Texas Southwestern Medical Center, Dallas, TX
11/01 Pulmonary Scholars Program, Duke University/University of North Carolina, Chapel Hill, NC
11/01 Research Seminar, Merck Frosst Center for Therapeutic Research, Dorval, Quebec, Canada
11/01 Pulmonary Research Conference, Duke University Medical Center, Durham, NC
11/01 Pulmonary Research Conference, Northwestern University Medical Center, Chicago, IL
11/01 Pulmonary Grand Rounds, Loyola University Medical Center, Chicago, IL
02/02 Pulmonary Fellows Conference, Brigham and Women’s Hospital, Boston, MA
02/02 Pulmonary Grand Rounds, Massachusetts General Hospital, Boston, MA
03/02 Research Seminar, Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan
03/02 Research Seminar, Minase Research Institute, Ono Pharmaceutical Co., Osaka, Japan
03/02 Pulmonary Grand Rounds, University of California-San Francisco, San Francisco, CA
03/02 Research Seminar, California Regional Primate Center, University of California-Davis, Davis, CA
03/02 Department of Medicine Grand Rounds, Stanford University, Palo Alto, CA
03/02 Pulmonary Grand Rounds, Stanford University, Palo Alto, CA
04/02 Department of Medicine Grand Rounds, Buffalo General Hospital, Buffalo, NY
04/02 City-Wide Grand Rounds, Buffalo, NY
08/02 Department of Immunology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil
08/02 School of Pharmaceutical Science, University of Sao Paulo-Ribeirao Preto, Ribeirao Preto, Brazil
10/02 Research Seminar, Allergy and Immunology Division Conference, Children’s Hospital of Detroit, Detroit, MI
02/03 Research Seminar, Vascular Biology Institute, University of Miami Medical Center, Miami, FL
02/03 Invited lecture, University of Tennessee College of Veterinary Medicine, Knoxville, TN
02/03 Pulmonary Grand Rounds, Boston University Medical Center
04/03 Department of Medicine Grand Rounds, Nassau University Medical Center, East Meadow, NY
04/03 Research Seminar, Inflammation Biology Department, Wyeth Research, Cambridge, MA
09/03 Department of Medicine Grand Rounds, University of Utah, Salt Lake City, UT
09/03 Pulmonary Grand Rounds, Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UT
11/03 Research Seminar, Lilly Research Laboratories, Indianapolis, IN
03/04 Seminar, Franklin & Marshall College, Lancaster, PA
03/04 Department of Medicine Grand Rounds, University of Saskatchewan, Saskatoon, Canada
03/04 Respirology Research in Progress Rounds, and Pediatric Respirology Research Rounds, University of Manitoba, Winnipeg, Canada
03/04 Respiratory Divisional Rounds, University of Calgary, Calgary, Canada
07/04 Pulmonary Department Research Seminar, Justus Liebig University, Giessen, Germany
08/04 Research Seminar, Pfizer, Inc., St. Louis, MO
08/04 Research Seminar, Critical Therapeutics, Inc., Lexington, MA
09/04 Pulmonary Division Research Conference, University of Pittsburgh, Pittsburgh, PA
09/04 Research Seminar, Allergy Conference, Pittsburgh Children’s Hospital and University of Pittsburgh, Pittsburgh, PA
10/04 Research Seminar, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia
10/04 Pulmonary Research Conference, Thomas Jefferson University, Philadelphia, PA
11/04 Research Seminar, Faculties of Medicine and Pharmacy, University of Sao Paulo Ribeirao Preto, Ribeirao Preto, Brazil
11/04 Pulmonary Division Research Conference, Vanderbilt University, Nashville, TN
03/05 Pulmonary Grand Rounds, Stanford University Medical Center, Palo Alto, CA
03/05 Research Seminar, Pfizer Research Laboratories, Ann Arbor, MI
06/05 Pulmonary Research Seminar, Johns Hopkins University, Baltimore, MD
06/05 Pulmonary Research Seminar, University of Virginia, Charlottesville, VA
07/05 Pulmonary Research Seminar, University of Cincinnati, Cincinnati, OH
10/05 Research Seminar, Tohoku University Medical Society, Sendai, Japan
10/05 Pulmonary Grand Rounds, Medical University of South Carolina, Charleston, SC
11/05 Pulmonary Research Seminar, Wake Forest University Medical Center, Winston-Salem, NC
11/05 Research Seminar, Division of Rheumatology, Immunology, and Allergy, Brigham & Women’s Hospital, Boston, MA
11/05 City-wide Pulmonary Rounds, Baylor College of Medicine, Houston, TX
12/05 Research Seminar, Division of Allergy, Pulmonary, Critical Care, and Sleep, University of Texas Medical Branch, Galveston, TX
03/06 Pulmonary Grand Rounds, University of British Columbia, St. Paul’s Hospital, Vancouver, BC, Canada
03/06 Pulmonary Research Conference, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada
03/06 Medical Grand Rounds, St. Louis University, St. Louis, MO
03/06 Asthma Conference, Divisions of Pulmonary and Critical Care Medicine and Allergy / Immunology, Washington University, St. Louis, MO
06/06 Pulmonary Grand Rounds, University of Alabama-Birmingham, Birmingham, AL
11/06 Allergy Research Conference, University of Washington, Seattle, WA
11/06 Respirology Rounds, University of Alberta, Edmonton, Alberta
11/06 Respiratory Clinical Rounds, University of Calgary, Calgary, Alberta
12/06 Yale State Chest Conference, Yale University, New Haven, CT
12/06 Research Conference, Pulmonary and Critical Care, Yale University, New Haven, CT
04/07 1) Clinical Rounds and 2) Research Rounds, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario
04/07 University Health Network Visiting Speaker Rounds, Toronto, Ontario
04/07 Respiratory Rounds, Toronto Western Hospital, Toronto, Ontario
04/07 Respiratory Rounds, Hotel Dieu, University of Montreal, Montreal, Quebec
04/07 Research Seminar, Meakins-Christie Laboratories, McGill University, Montreal, Quebec
04/07 Keynote Speaker, Annual Research Day, Respiratory Research Group, Laval University, Quebec City, Quebec
09/07 Respirology Rounds, St. Joseph’s Hospital, London, Ontario
10/07 Pulmonary Grand Rounds, Mt. Sinai Medical Center, New York, NY
10/07 Research Seminar, DeCODE Genetics, Brighton, MI
11/07 Research Seminar, Immunology Department, University of Sao Paulo, Sao Paulo, Brazil
11/07 Research Seminar, College of Pharmacy, University of Sao Paulo-Ribeirao Preto, Ribeirao Preto, Brazil
11/07 Research Seminar, Division of Pulmonary and Allergy, University of Barcelona
08/08 Research Seminar, Lilly Research Laboratories, Indianapolis, IN
09/08 Research Seminar, Nycomed GmbH, Konstanz, Germany
10/08 Medical Grand Rounds and Pulmonary Research Conference, Ohio State University Medical Center, Columbus, OH
11/08 Research Seminar, Division of Allergy, Pulmonary, Critical Care, and Sleep, University of Texas Medical Branch, Galveston, TX
12/08 Speaker, Prostacyclin Basic Science Advisory Forum, Actelion Pharmaceuticals, New York, NY
03/09 Speaker, Expert Symposium on Resolution of Inflammation, Boehringer Ingelheim, Inc., Biberach, Germany
03/09 Department of Medicine Grand Rounds and Pulmonary Research Conference, University of Illinois-Chicago Medical Center, Chicago, IL
06/09 Research Seminar, Wyeth Research, Cambridge, MA
07/09 Speaker, University of Giessen Graduate Program in Molecular Biology and Medicine of the Lung Annual Retreat, Giessen, Germany
07/09 Research Seminar, University of Frankfurt, Frankfurt, Germany
01/10 Research Seminar, Nycomed GmbH, Konstanz, Germany
11/10 Research Seminar, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
11/10 Research Seminar, University of Sao Paulo-Ribeirao Preto, Ribeirao Preto, Brazil
11/10 Research Seminar, State University of Sao Paulo-Araraquara, Araraquara, Brazil
12/10 Research Seminar, Immuno Inflammation Unit, Sanofi-Aventis, Bridgewater, NJ
03/11 Research Seminar, Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO
04/11 Research Seminar, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA
10/11 Research Seminar, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
10/11 Research Seminar, Pulmonary Division, University of Sao Paulo Medical School, Sao Paulo, Brazil
10/11 Research Seminar, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
03/12 Special Seminar, Gil Hospital of Gachon Medical School, Seoul, Korea
04/12 Research Seminar, Division of Pulmonary and Critical Care, University of Vermont, Burlington, VT
09/12 Research Seminar, Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands
11/12 Research Seminar, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN
12/12 Research Seminar, Centre for Inflammation & Tissue Repair, University College London, and the London Matrix Group, London, UK
1/13 The 2013 Harold and Marilyn Menkes Memorial Lecture, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD
Committee and Administrative Services
|National: |
1991 Program Committee for annual meeting of The American Thoracic Society, Scientific Assembly on Respiratory Cell and Molecular Biology
1995-01 Program Committee for annual meeting of The American Thoracic Society, Scientific Assembly on Allergy, Immunology, and Inflammation; Chair-elect, 1999-2000; Chair, 2000-2001
1997-98 Member of Nominating Committee, scientific assembly on Allergy, Immunology, and Inflammation, American Thoracic Society
1999-02 Member of Planning Committee, scientific assembly on Allergy, Immunology, and Inflammation, American Thoracic Society
2010- Research Advocacy Committee, American Thoracic Society
2012- Advisory Board, American Thoracic Society Research Quarterly Newsletter
|Community Service: |
1993-00 Board of Directors, American Lung Association of Michigan; 1995-1997 Executive Committee
1995-01 Chair, Grants and Awards Committee, American Lung Association of Michigan
1998-99 Search Committee, Chief Executive Officer, American Lung Association of Michigan
|Hospital and Medical School: |
1986-90 Research and Development Committee, Ann Arbor Department of Veterans’ Affairs Medical Center; Chairperson, 7/89-6/90
1988-94 Critical Care Committee, Ann Arbor Department of Veterans’ Affairs Medical Center
1991-93 Endoscopy Committee, Ann Arbor Department of Veterans’ Affairs Medical Center
2003-07 Admissions Committee, University of Michigan Medical School
2004-06 Preliminary Examination Committee, Graduate Program in Immunology, University of Michigan Medical School
2007-2010 Scientific Advisory Board, University of Michigan Clinical and Translational Science Award
2007-2010 Scientific Review Committee, University of Michigan Clinical and Translational Science Award
|Departmental: |
1985-88 House Officer Selection Committee, Department of Internal Medicine, University of Michigan
1986 Planning Committee, Advances in Internal Medicine Course, Department of Internal Medicine, University of Michigan
1993 Ad Hoc Committee on Laboratory Safety, Department of Internal Medicine, University of Michigan
1994-96 Advisory Committee for Research, Department of Internal Medicine, University of Michigan
1996-02 Promotions Committee, Department of Internal Medicine, University of Michigan; Chair, 1999-2002
1999- Member, Department of Internal Medicine Education Committee, University of Michigan
2002-05 Member, Department of Internal Medicine Awards Committee, University of Michigan
2008 Internal Review Committee, GI SPORE application, Dean Brenner, M.D., Principal Investigator
Patents
6/8/99 U.S. Patent No. 5,909,734. “Administration of products of the 5-lipoxygenase metabolic pathway to enhance antimicrobial defense." Technology licensed in 2002 to Virocell; currently held by LTB4 Sweden AB.
Audiovisual Programs
2001 Program Chairman and Lecturer, “Virtual Asthma-Free Zone,” an educational CD-ROM about anti-leukotriene agents in the treatment of asthma, sponsored by the Postgraduate Institute for Medicine and supported by an unrestricted educational grant from Merck & Co., Inc.
2002 Lecturer, “Straight Talk on Singulair,” an educational CD-ROM about anti-leukotriene agents in the treatment of asthma, produced by Merck & Co., Inc.
2013 Lecturer, “Influence of Eicosanoid Lipid Mediators on Macrophage Innate Immune Functions,” in series on Macrophage Heterogeneity and Function, organized by Professor Siamon Gordon, Henry Stewart Talks, London
Bibliography
1. Rosen JA, Pike CS, Golden ML. Zinc, iron, and chlorophyll metabolism in zinc-toxic corn. Plant Physiol 1977; 59:1085-1087
2. Crapo JD, Peters-Golden M, Marsh-Salin J, Shelburne JJ, Vollmer R. Pathologic changes in the lungs of oxygen-adapted rats -- a morphometric analysis. Lab Invest 1978; 39:640-653, PMID: 7349764
3. Peters-Golden M, Wise RA, Schneider P, Hochberg M, Stevens MB, Wigley F. Clinical and demographic predictors of loss of pulmonary function in systemic sclerosis. Medicine 1984; 63:221-231, PMID: 6738343
4. Peters-Golden M, Bathon J, Flores R, Hirata F, Newcombe DS. Glucocorticoid inhibition of zymosan-induced arachidonic acid release by rat alveolar macrophages. Am Rev Respir Dis 1984; 130:803-809, PMID: 647305
5. Peters-Golden M, Wise RA, Hochberg MC, Stevens MB, Wigley FM. Carbon monoxide diffusing capacity as predictor of outcome in systemic sclerosis. Am J Med 1984; 77:1027-1034, PMID: 6507456
6. Peters-Golden M, Wise RA, Hochberg M, Stevens MB, Wigley FM. Incidence of lung cancer in systemic sclerosis. J Rheumatol 1985; 12:1136-1139, PMID: 4093920
7. Peters-Golden M, Thebert P. Inhibition by methylprednisolone of zymosan-induced leukotriene synthesis in alveolar macrophages. Am Rev Respir Dis 1987; 135:1020-1026, PMID: 3034108
8. Peters-Golden M, Shelly C. Modulation of alveolar macrophage-derived leukotriene synthesis by the sulfhydryl reactant N-ethylmaleimide. J Biol Chem 1987; 262:10594-10600, PMID:3112148
9. Sporn PHS, Peters-Golden M, Simon RH. Hydrogen peroxide-induced arachidonic acid metabolism in the rat alveolar macrophage. Am Rev Respir Dis 1988; 137:49-56, PMID:3122612
10. Chauncey, JB, Peters-Golden M, Simon RH. Arachidonic acid metabolism by rat alveolar epithelial cells. Lab Invest 1988;58:133-140, PMID: 2828765
11. Peters-Golden M, Shelly C. Inhibitory effect of exogenous arachidonic acid on alveolar macrophage 5-lipoxygenase metabolism: role of ATP depletion. J Immunol 1988; 140:1958-1966, PMID: 3126237
12. Gravelyn TR, Brophy N, Siegert C, Peters-Golden M. Hypophosphatemia-associated respiratory muscle weakness in a general inpatient population. Am J Med 1988; 84:870-876, PMID: 3364446
13. Chauncey JB, Simon RH, Peters-Golden M. Rat alveolar macrophages synthesize leukotriene B4 and 12-hydroxyeicosatetraenoic acid from alveolar epithelial cell-derived arachidonic acid. Am Rev Respir Dis 1988; 138:928-935, PMID: 2849344,
14. Sporn PHS, Peters-Golden M. Hydrogen peroxide inhibits alveolar macrophage 5-lipoxygenase metabolism in association with depletion of ATP. J Biol Chem 1988; 263:14776-14783, PMID: 2844785
15. Balter MS, Eschenbacher WL, Peters-Golden M. Arachidonic acid metabolism in cultured alveolar macrophages from normal, atopic, and asthmatic subjects. Am Rev Respir Dis 1988; 138:1134-1142, PMID: 3144211
16. Peters-Golden M, Shelly C. The oral gold compound auranofin triggers macrophage arachidonate release and cyclooxygenase metabolism. Prostaglandins 1988; 36:773-786, PMID: 3244832
17. Balter MS, Toews GB, Peters-Golden M. Different patterns of arachidonate metabolism in autologous human blood monocytes and alveolar macrophages. J Immunol 1989; 142:602-608, PMID: 2536058
18. Peters-Golden M, Shelly C. Inhibition of alveolar macrophage 5-lipoxygenase metabolism by auranofin. Biochem Pharmacol 1989; 38:1589-1595, PMID: 2499339
19. Peters-Golden M, Shelly C, Morganroth M. Inhibition of rat lung glutathione synthesis attenuates hypoxic pulmonary vasoconstriction and the associated leukotriene C4 production. Am Rev Respir Dis 1989; 140:1210-1215, PMID: 2817583
20. Balter MS, Toews GB, Peters-Golden M. Multiple defects in arachidonate metabolism in alveolar macrophages from young asymptomatic smokers. J Lab Clin Med 1989; 114:662-673, PMID: 2512364
21. Sporn PHS, Murphy T, Peters-Golden M. Complex effects of in vitro hyperoxia on alveolar macrophage arachidonic acid metabolism. Am J Respir Cell Mol Biol 1990; 2:81-90, PMID: 2155014
22. Peters-Golden M, McNish RW, Hyzy R, Shelly C, Toews GB. Alterations in the pattern of arachidonate metabolism accompany rat macrophage differentiation in the lung. J Immunol 1990; 144:263-270, PMID:2104888
23. Peters-Golden M, McNish RW, Brieland JK, Fantone JC. Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. J Immunol 1990; 144:4320-6, PMID: 2160499
24. Sporn PHS, Murphy T, Peters-Golden M. Glucocorticoids fail to inhibit hydrogen peroxide-induced arachidonic acid metabolism in the alveolar macrophage. J Leukocyte Biol 1990; 48:81-88, PMID: 2358752
25. Lipchik RJ, Chauncey J, Paine R, Simon RH, Peters-Golden M. Arachidonate metabolism increases as rat alveolar type II cells differentiate in vitro. Am J Physiol (Lung Cell Mol Physiol) 1990; 259:L73-L80, PMID: 1696434
26. Sporn PHS, Marshall TM, Peters-Golden M. Differential dependence on protein kinase C of arachidonic acid stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage. Biochem Biophys Acta 1990; 1047:187-191, PMID: 2123406
27. Peters-Golden M, McNish RW, Marshall TM, Sporn PHS, Balazovich K. Basal activation of protein kinase C in rat alveolar macrophages: implications for arachidonate metabolism. Am J Physiol (Lung Cell Mol Physiol) 1991; 261:L462-L47, PMID: 1662919
28. Gray PR, Derksen FJ, Robinson NE, Slocombe RF, Peters-Golden ML. Epithelial strips: an alternative technique for examining arachidonate metabolism in equine tracheal epithelium. Am J Respir Cell Mol Biol 1992; 6:29-36, PMID: 1728292
29. Coffey M, Peters-Golden M, Fantone JC, Sporn PHS. Membrane association of active 5-lipoxygenase in resting cells: evidence for novel regulation of the enzyme in the rat alveolar macrophage. J Biol Chem 1992; 267:570-576, PMID: 1309754
30. Gray PR, Derksen FJ, Broadstone R, Robinson NE, Peters-Golden M. Decreased airway mucosal PGE2 production during airway obstruction in an animal model of asthma. Am Rev Respir Dis 1992; 146:586-591, PMID: 1519833
31. Peters-Golden M, Coburn K, Chauncey JB. Protein kinase C activation modulates arachidonic acid metabolism in cultured alveolar epithelial cells. Exp Lung Res 1992; 18:535-551, PMID: 1516571
32. Sporn PHS, Marshall TM, Peters-Golden M. Hydrogen peroxide increases the availability of arachidonic acid for oxidative metabolism by inhibiting acylation into phospholipids in the alveolar macrophage. Am J Respir Cell Mol Biol 1992; 7:307-316, PMID: 1520493
33. Atluru D, Peters-Golden M, Keane WF. Effects of immunosuppressive agents, cyclosporin A, FK-506 and genistein, on the synthesis of 5-lipoxygenase metabolites of arachidonic acid by human mononuclear cells. Biochem Archives 1992; 8:151-160,
34. Neagos GR, Feyssa A, Peters-Golden M. Phospholipase A2 in alveolar type II epithelial cells: biochemical and immunologic characterization. Am J Physiol (Lung Cell Mol Physiol 8) 1993; 264: L261-L268, PMID: 8460714
35. Peters-Golden M, Feyssa A. Transcellular eicosanoid synthesis in co-cultures of alveolar epithelial cells and macrophages. Am J Physiol (Lung Cell Mol Physiol 8) 1993; 264:L438-L447, PMID: 8498522
36. Peters-Golden M, McNish RW. Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation. Biochem Biophys Res Commun 1993; 196:147-153, PMID: 8216286
37. Coffey MJ, Gyetko M, Peters-Golden M. 1,25-Dihydroxyvitamin D3 upregulates 5-lipoxygenase metabolism and 5-lipoxygenase activating protein in peripheral blood monocytes as they differentiate into mature macrophages. J Lipid Mediators 1993; 6:43-51, PMID: 8358002
38. Peters-Golden M, Feyssa A. Augmented expression of cytosolic phospholipase A2 during phenotypic transformation of cultured type II pneumocytes. Am J Physiol (Cell Physiol 35) 1994; 266:C382-C390, PMID: 8141252
39. Coffey MJ, Wilcoxen SE, Peters-Golden M. Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism which accompanies differentiation of peripheral blood monocytes into alveolar macrophages. Am J Respir Cell Mol Biol, 1994; 11:153-158, PMID: 8049076
40. Brock TG, Paine R III, Peters-Golden M. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. J Biol Chem 1994; 269:22059-22066, PMID: 8071328
41. Coffey MJ, Wilcoxen SE, Simpson RU, Gyetko MR, Peters-Golden M. Reduced 5-lipoxygenase metabolism in macrophages from 1,25-dihydroxyvitamin D3-deficient rats. Prostaglandins 1994; 48:313-329, PMID: 7855310
42. Wilborn J, DeWitt DL, Peters-Golden M. Expression and role of cyclooxygenase isoforms in alveolar and peritoneal macrophages. Am J Physiol (Lung Cell Mol Physiol 12) 1995; 268:L294-L301, PMID: 7864149
43. Wilborn J, Crofford LJ, Burdick MD, Kunkel SL, Strieter RM, Peters-Golden M. Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J Clin Invest 1995; 95:1861-1868, PMID: 7706493
44. Woods JW, Coffey MJ, Brock, TJ, Singer II, Peters-Golden M. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J Clin Invest 1995; 95:2035-2046, PMID: 7738170
45. Bailie MB, Dahm LJ, Peters-Golden M, Harris RR, Carter GW, Roth RA. Leukotrienes and a-naphthylisothiocyanate-induced liver injury. Toxicology 1995; 100:139-149, PMID: 7624871
46. Brock TG, McNish R, Peters-Golden M. Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J Biol Chem 1995; 270:21652-21658, PMID: 7665580
47. Tithof PK, Schiamberg E, Peters-Golden M, Ganey PE. Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls. Env Health Perspect 1996; 104:2-7, PMID: 8834862
48. Brock TG, McNish RW, Coffey M, Ojo TC, Phare SM, Peters-Golden M. Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. J Immunol 1996; 156:2522-2527, PMID: 8786314
49. Wilborn J, Bailie M, Coffey M, Burdick M, Strieter R, Peters-Golden M. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest 1996; 97:1827-1836, PMCID: PMC507250
50. Coffey MJ, Phare S, Kazanjian P, Peters-Golden M. 5-lipoxygenase metabolism in alveolar macrophages from subjects infected with the human immunodeficiency virus. J Immunol 1996; 157:393-399, PMID: 8683143
51. Peters-Golden M, Song K, Marshall T. Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis. Biochem J 1996; 318:797-803, PMCID: PMC1217689
52. Lu M-C, Peters-Golden M, Hostetler DE, Robinson NE, Derksen FJ. Age-related enhancement of 5-lipoxygenase metabolic capacity in cattle alveolar macrophages. Am J Physiol (Lung Cell Mol Physiol 15) 1996; 271:L547-554, PMID: 8897901
53. Peters-Golden M, McNish RW, Davis JA, Brock TG. Colchicine inhibits arachidonate release and 5-lipoxygenase action in alveolar macrophages. Am J Physiol (Lung Cell Mol Physiol 15) 1996; 271:L1004-1013, PMID: 8997272
54. Bailie MB, Standiford TJ, Laichalk LL, Coffey MJ, Strieter R, Peters-Golden M. Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J Immunol 1996; 157:5221-5224, PMID: 8955165
55. Coffey MJ, Wheeler CS, Gross KB, Eschenbacher WL, Sporn PHS, Peters-Golden M. Increased 5-lipoxygenase metabolism in alveolar macrophages obtained from subjects exposed in vivo to ozone. Toxicology 1996; 114:187-197, PMID: 8980708
56. Brock TG, McNish RW, Bailie MB, Peters-Golden M. Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils following in vivo recruitment and in vitro adherence. J Biol Chem 1997; 272:8276-8280, PMID: 9079648
57. Ruffin MT, Krishnan K, Rock CL, Normolle D, Vaerten MA, Crowell J, Kelloff G, Boland CR, Peters-Golden M, Brenner DE. Suppression of human colorectal mucosal prostaglandins: determining thelowest effective aspirin dose. J Natl Cancer Inst 1997; 89:1152-1160, PMID: 9262254
58. Tithof PK, Peters-Golden M, Ganey PE. Distinct phospholipase A2s regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils. J Immunol 1998; 160:953-960, PMID: 9551934
59. Brock TG, McNish RW, Peters-Golden M. Capacity for repeatable leukotriene generation following transient stimulation of mast cell and macrophages. Biochem J 1998; 329:519-525, PMCID: PMC1219072
60. Coffey MJ, Phare SM, George S, Peters-Golden M, Kazanjian PH. Granulocyte colony-stimulating factor administration to HIV-infected subjects augments reduced leukotriene synthesis and anticryptococcal activity in neutrophils. J Clin Invest 1998; 102:663-670, PMCID: PMC508927
61. Covin RB, Brock TG, Bailie MB, Peters-Golden M. Altered expression and localization of 5-lipoxygenase accompany macrophage differentiation in the lung. Am J Physiol (Lung Cell Mol Physiol 19) 1998; 275: L303-L310, PMID: 97000091
62. Mancuso P, Standiford TJ, Marshall T, Peters-Golden M. 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. Infect Immun 1998; 66:5140-5146. , PMCID: PMC108641
63. Phare SM, Peters-Golden M, Coffey MF. Alveolar lining fluid regulates mononuclear phagocyte 5-lipoxygenase metabolism. Eur Respir J 1998; 12:1141-1146, PMID: 9864011
64. Coffey MJ, Wilcoxen SE, Sporn PH, Peters-Golden. Regulation of 5-lipoxygenase activity in mononuclear phagocytes: characterization of an endogenous cytosolic inhibitor. Prostaglandins 1998; 56:103-117, PMID: 9785381
65. Peters-Golden M. Cell biology of the 5-lipoxygenase pathway. Am J Respir Crit Care Med 1998; 157:5227-5232, PMID: 9620944
66. Peters-Golden M. Molecular mechanisms of leukotriene synthesis: The changing paradigm. Clin Exp Allergy 1998; 28:1059-1065, PMID: 9761008
67. Peters-Golden M, Coffey M. Role of leukotrienes in antimicrobial defense of the lung. J Lab Clin Med 1998; 132:251-257, PMID: 9794695
Peters-Golden M. Pulmonary diseases other than asthma as potential argets for antileukotrine therapy. Clin Rev Allery Immunol 1999; 17(1-2):247-60 Review. 1043687010436870, PMID: 10436870
68. Brock TG, Anderson JA, Fries FP, Peters-Golden M, Sporn PHS. Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. J Immunol 1999 162:1669-1676, PMID: 9973428
69. Brock TG, McNish RW, Peters-Golden M. Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J Biol Chem 1999; 274:11660-11666, PMID: 10206978
70. Bae J, Peters-Golden M, Loch-Caruso R. Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. J Pharmacol Exp Ther 1999; 289:1112-1120, PMID: 10215694
71. Healy AM, Peters-Golden M, Yao JP, Brock TG. Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase. J Biol Chem 1999; 274:29812-29818, PMID: 10514459
72. Coffey MJ, Phare SM, Cinti S, Peters-Golden M, Kazanjian PH. Granulocyte-macrophage colony–stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome. Blood 1999; 94:3897-3905, PMID: 10572106
73. Coffey MJ, Phare SM, Peters-Golden M, Huffnagle GB. Regulation of 5-lipoxygenase metabolism in mononuclear phagocytes by CD4 T lymphocytes. Exp Lung Res 1999; 25:617-629, PMID: 10598321
74. Moore BB, Coffey M, Christensen P, Sitterding S, Ngan R, McDonald R, Phare S, Peters-Golden M, Paine R, Toews GB. GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. J Immunol 2000; 165:4032-4039, PMID: 11034414
75. Coffey MJ, Phare SM, Peters-Golden M. Prolonged exposure to lipopolysaccharide inhibits macrophage 5-lipoxygenase metabolism via induction of nitric oxide synthesis. J Immunol 2000; 165:3592-3598, PMID: 11034360
76. Mancuso P, Peters-Golden M. Modulation of alveolar macrophage phagocytosis by leukotrienes is Fc receptor-mediated and protein kinase C-dependent. Am J Respir Cell Mol Biol 2000; 23:727-733, PMID: 11104724
77. Peters-Golden M, Brock TG. Intracellular compartmentalization of leukotriene biosynthesis. Am J Respir Crit Care Med 2000; 161:536-540, PMID: 11163352
78. Peters-Golden M. Playing “telephone”: bioactive lipids as mediators of intercompartmental communication in the alveolus. Commentary. J Clin Invest 2000; 105:857-858, PMCID: PMC377491
79. Peters-Golden M, Brock TG. Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets. FEBS Letters 2001; 487:323-326, PMID: 10673224, PMID: 11163352
80. Mancuso P, Nana-Sinkam P, Peters-Golden M. Leukotriine B4 augments neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun 2001; 69:2011-2016, PMCID: PMC98124
81. Stichtenoth DO, Thoren S, Bian H, Peters-Golden M, Jakobsson P-J, Crofford LJ. Microsomal prostaglandin E synthase is regulated by pro-inflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J Immunol 2001; 167:469-474, PMID: 11418684
82. Krishnan K, Ruffin MT, Normolle D, Shureiqi I, Burney K, Bailey J, Peters-Golden M, Rock CL, Boland CR, Brenner DE. Colonoic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in high-risk and normal-risk subjects for colorectal cancer: surrogate endpoint markers of drug effect. Cancer Epidemiol Biomarkers Prev 2001; 10:447-453, PMID: 11352853
83. Reddy RC, Chen GH, Tateda K, Tsai WC, Phare SM, Mancuso P, Peters-Golden M, Standiford TJ. Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis. Am J Physiol Lung Cell Mol Physiol 2001; 281:L537-43, PMID: 11504678
84. Uz T, Dwiredi Y, Quele A, Peters-Golden M, Pandey G, Manev H. Glucocorticoid receptors are required for upregulation of neuronal 5-lipoxygenase (5LOX) expression by dexamethasone. FASEB J 2001; 15:1792-4, PMID: 11481232
85. Peters-Golden M. Regulation of the leukotriene biosynthetic pathway. Clin Exp Allergy Rev 2001; 1:128-132
86. Peters-Golden M. Potential role of leukotrienes in other disease states. Clin Exp Allergy Rev 2001; 1:178-182
87. Brock TG, Maydanski E, McNish RW, Peters-Golden M. Co-localization of leukotriene A4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils. J Biol Chem 2001; 276:35071-35077, PMID: 11451962
88. Mancuso P, McNish RW, Peters-Golden M, Brock TG. Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rates of different ages. Mech Ageing Dev 2001; 122(15):1899-1913, PMID: 11557288
89. Coffey MJ, Phare SM, Peters-Golden M. Peroxynitrite-induced nitrotyrosination of proteins blocked by the direct 5-lipoxygenase inhibitor zileuton. J Pharmacol Exp Ther 2001; 299:198-203, PMID: 11561080
90. Sud’ina GF, Brock TG, Pushkareva MA, Galkina SI, Turutin DV, Peters-Golden M, Ullrich V. Sulfatides trigger polymorphonuclear granulocyte attachment to collagen-coated surfaces and inhibit subsequent activation of 5-lipoxygenase. Biochem J 2001; 359:621-629, PMCID: PMC1222184
91. Wang C-T, Peters-Golden M, Loch-Caruso R. A calcium-independent phospholipase activity insensitive to bromoenol lactone mediates arachidonic acid release by lindane in rat myometrial cells. Life Sci 2001; 70:453-470, PMID: 11798014
92. Peters-Golden M, Bailie M, Marshall T, Wilke C, Phan SH, Toews GB, Moore BB. Protection from pulmonary fibrosis in leukotriene-deficient mice. Am J Respir Crit Care Med 2002; 165:229-235, PMID: 11790660
93. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB. Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J Immunol 2002; 168:4018-4024, PMID: 11937559
94. Peters-Golden M. Open mind, open airways: broadening the paradigm of prostaglandins and allergic airway inflammation. Editorial. Am J Respir Crit Care Med 2002; 165:1035-1036, PMID: 11956040
95. Peters-Golden M. “Good” lipids for asthma. Nat Med 2002; 8:931-932. , PMID: 12205450
96. Tithof PK, Elgayyar M, Cho Y, Guan W, Fisher AB, Peters-Golden M. Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. FASEB J 2002 16(11): 1463-4, PMID: 12205049
97. Jones SM, Luo M, Healy AM, Peters-Golden M, Brock TG. Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein. J Biol Chem 2002; 11:277(41):38550-6, PMID: 124140292
98. Coffey MJ, Phare SM, Peters-Golden M. Interaction between nitric oxide, reactive oxygen intermediates, and peroxynitrite in the regulation of 5-lipoxygenase metabolism. Biochim Biophys Acta 2002; 1584:81-90, PMID: 12385890
99. Lama V, Moore BB, Christensen P, Toews GB, Peters-Golden M. Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent. Am J Respir Cell Mol Biol 2002; 27:752-758, PMID: 12444036
100. Peters-Golden M, Sampson AP. Cysteinyl leukotriene interactions with other mediators and with glucocorticosteroids during airway inflammation. J Allergy Clin Immunol 2003; 111(1 Suppl)S37-42 discussion S34-6, PMID: 12532085
101. Holgate ST, Peters-Golden M. Introduction: the anti-inflammatory role of cysteinyl leukotriene receptor antagonists in asthma. J Allergy Clin Immunol. 2003; 111(1Suppl):S1-4 , PMID: 12532082
102. Holgate ST, Peters-Golden M, Panettieri RA, Henderson WR Jr. Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol 2003; 111(1Suppl)S18-S36. PMID: 12532084
103. Coffey MJ, Peters-Golden M. Extending the understanding of leukotrienes in asthma. Curr Opin Allergy Clin Immunol 2003;3(1):57-63, PMID: 12582316
104. Moore BB, Peters-Golden M, Christensen PJ, Lama V, Kuziel WA, Paine R III, Toews GB. Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2. Am J Physiol: Lung Cell Mol Physiol 2003; 284:(2)L342-L349, PMID: 12388376
105. Jones SM, Luo M, Peters-Golden M, Brock, TG. Identification of two novel nuclear import sequences on the 5-lipoxygenase protein. J Biol Chem 2003; 21:278(12):10257-63, PMID: 1252477
106. Brock TG, Peters-Golden M. 5-Lipoxygenase and FLAP. Prostaglandins Leukot Essent Fatty Acids 2003; 69:99-109, PMID: 12895592
107. Charbeneau RP, Christensen PJ, Chrisman CJ, Paine R III, Toews GB, Peters-Golden M, Moore BB. Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation. Am J Physiol: Lung Cell Mol Physiol 2003; 284(6):L1103-L1111, PMID: 12598228
108. Peters-Golden M. Do anti-leukotriene agents inhibit asthmatic inflammation? Clin Exp Allergy 2003; (6)33:721-724, PMID: 12801303
109. Brock TG, McNish RW, Mancuso P, Coffey M, Peters-Golden M. Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandins. Prostaglandins Other Lipid Mediators 2003; 71(3-4):131-145, PMID: 14518557
110. Canetti CA, Hu B, Curtis JL, Peters-Golden M. Syk activation is a leukotriene B4-regulated event in Fcγ receptor- but not phosphatidylserine receptor-mediated phagocytosis in macrophages. Blood 2003; 102(5):1877-1883, PMID: 12730109
111. Kolodsick J, Peters-Golden M, Larios J, Toews GB, Thannickal V Moore BB. PGE2 inhibits myofibroblast differentiation via EP2 signaling and cAMP elevation. Am J Respir Cell Mol Biol 2003; 29(5):537-544, PMID: 12738687
112. Luo M, Jones SM, Peters-Golden M, Brock TG. Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity. Proc Natl Acad Sci USA 2003; 100(21):12165-12170, PMCID: PMC218730
113. Peters-Golden M. When defenses against fibroproliferation fail: spotlight on an axis of prophylaxis. Editorial. Am J Respir Crit Care Med 2003; 168(10):1141-1142, PMID: 1467817
114. Peters-Golden M. The alveolar macrophage: the forgotten cell in asthma. Perspective. Am J Respir Cell Mol Biol 2004; 31(1):3-7, PMID: 15208096
115. Aronoff DM, Canetti C, Peters-Golden M. Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an EP2 receptor-mediated increase in cyclic AMP. J Immunol 2004; 173(1):559-565, PMID: 15210817
116. Coffey MJ, Phare SM, Peters-Golden M. Role of leukotrienes in killing of Mycobacterium bovis by neutrophils. Prostaglandins Leukot Essent Fatty Acids 2004; 71(3):185-90, PMID: 15253889
117. Coffey MJ, Phare SM, Peters-Golden M. Induction of iNOS by LPS/interferon gamma and sepsis downregulates 5-lipoxygenase metabolism in murine alveolar macrophages. Exp Lung Res 2004; 30(7):615-633, PMID: 15371096
118. Mancuso P, Gottschalk A, Marshall T, Peters-Golden M. Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2γ) protein expression. Am J Physiol Lung Cell Mol Physiol 2004; 287(3):L497-502, PMID: 15145787
119. Luo M, Jones SM, Phare SM, Coffey MJ, Peters-Golden M, Brock TG. Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. J Biol Chem 2004; 279(40):41512-41520, PMID: 1580375
120. Aronoff DM, Canetti C, Serezani CH, Luo M, Peters-Golden M. Cutting edge: macrophage inhibition by cAMP: differential roles of protein kinase A and exchange protein activated by cAMP-1. J Immunol 2005; 174(2):595-599, PMID: 15634874
121. Peters-Golden M, Canetti C, Mancuso P, Coffey MJ. Leukotrienes: underappreciated mediators of innate immune responses. J Immunol 2005; 174(2):589-594, PMID: 15634873
122. Benjamim C, Canetti C, Cunha FQ, Kunkel SL, Peters-Golden M. Opposing and hierarchical roles of leukotrienes in innate immune and vascular responses in a model of sepsis. J Immunol 2005; 174(3):1616-1620, PMID: 15661924
123. White ES, Atrasz RG, Dickie EG, Aronoff DM, Peters-Golden M. Prostaglandin E2 inhibits fibroblast migration by EP2 receptor-mediated increase in PTEN activity. Am J Respir Cell Mol Biol 2008; 39(2):252, PMID: 15539859
124. Moore BB, Ballinger MN, White ES, Green ME, Herrygers AB, Wilke CA, Toews GB, Peters-Golden M. Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2. J Immunol 2005; 174(9):5644-5649, PMID: 15843564
125. Charbeneau RP, Peters-Golden. Eicosanoids: mediators and therapeutic targets in fibrotic lung disease. Clin Sci (Lond) 2005; 108(6):479-491, PMID: 15896193
126. Peters-Golden M, Henderson WR, Jr. The role of leukotrienes in allergic rhinitis. Ann Allergy Asthma Immunol 2005; 94(6):609-618, PMID: 15984591
127. Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M. Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood 2005; 106(3):1067-1075, PMCID: PMC1985163
128. Lama VN, Murray S, Mumford JA, Flaherty KR, Chang A, Toews GB, Peters-Golden M, Martinez FJ. Prognostic value of bronchiolitis obliterans syndrome stage 0-p in single lung transplant recipients. Am J Respir Crit Care Med 2005; 172(3):379-383, PMCID: PMC2718475
129. Brock TG, Lee Y-J, Maydanski E, Marburger TL, Paine R III, Peters-Golden M. Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung. Am J Physiol Lung Cell Mol Physiol 2005; 289(2):L224-232, PMID: 15805137
130. Luo M, Jones SM, Flamand N, Aronoff D, Peters-Golden M, Brock TG. Phosphorylation by protein kinase A inhibits nuclear import of 5-lipoxygenase. J Biol Chem 2005; 280(49):40609-40616, PMID: 16230355
131. Serezani CH, Aronoff DM, Jancar S, Peters-Golden M. Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. J Leukoc Biol 2005; 78(4):976-984, PMID: 16006535
132. Mancuso P, Huffnagle GB, Olszewski MA, Phipps J, Peters-Golden. Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med 2006; 173(2):212-218, PMID: 16210671
133. Aleksandrov D, Zagryagskaya A, Pushkareva M, Bachschmid M, Peters-Golden M, Werz O, Steinhilber D, Sud’ina G. Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac 6 cells. FEBS Lett 2006; 273(3):548-557, PMID: 16420478
134. Moore BB, Peters-Golden. Opposing roles of leukotrienes and prostaglandins in fibrotic lung disease. Expert Rev Clin Immunol 2006; 2(1):87-100, PMID: 20477090
135. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006; 27(3):495-503, PMID: 16507848
136. Gupta SK, Peters-Golden M, Fitzgerald JF, Croffie JM, Pfefferkorn MD, Molleston JP, Lim JR. Cysteinyl leukotriene levels in esophageal mucosal biopsies of children with eosinophilic inflammation: are they all the same? Am J Gastroenterol 2006; 101(5):1125-1128, PMID: 16573772
137. Peters-Golden M, Gleason MM, Togias A. Cysteinyl leukotrienes: multifunctional mediators in allergic rhinitis. Clin Exp Allergy 2006; 36(6):689-703, PMCID: PMC1569601
138. Canetti C, Choe M, Flamand N, Aronoff D, Wettlaufer S, Toews GB, Chen-G-H, Peters-Golden M. Differential regulation by leukotrienes and calcium of Fcγ receptor-induced phagocytosis and Syk activation in dendritic cells vs. macrophages. J Leukoc Biol 2006; 79(6):1234-1241, PMID: 16574771
139. Serezani CH, Perrela JH, Russo M, Peters-Golden M, Jancar S. Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility. J Immunol 2006; 177(5):3201-3208, PMID: 16920959
140. Ballinger MN, Aronoff DM, McMillan TR, Cooke KR, Olkiewicz K, Toews GB, Peters-Golden M, Moore, BB. Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation. J Immunol 2006; 177(8):5499-5508, PMID: 17015736
141. Aronoff DM, Carstens JK, Chen G-H, Toews GB, Peters-Golden M. Short Communication: differences between macrophages and dendritic cells in the cyclic AMP dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res 2006; 26(11):827-833, PMID: 17115901
142. Aronoff DM, Peres CM, Serezani CH, Ballinger MN, Carstens JK, Coleman N, Moore BB, Peebles RS, Faccioli LH, Peters-Golden M. Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities. J Immunol 2007; 178(3):1628-1634, PMID: 17237412
143. Huang S, Wettlaufer SH, Hogaboam C, Aronoff DM, Peters-Golden M. Prostaglandin E2 suppresses collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2/cyclic AMP/protein kinase A. Am J Physiol Lung Cell Mol Physiol 2007; 292(2):L405-413, PMID: 17028262
144. Peres CM, De Paula L, Medeiros AI, Soares EG, Sorgi CA, Carlos D, Peters-Golden M, Silva CL, Faccioli LH. Leukotrienes are an essential regulator of the protective immune response in murine tuberculosis. Microbes Infect 2007; 9(4):483-489, PMCID: PMC2581410, NIHMS23156
145. Lama VN, Smith L, Badri L, Flint AJ, Andrei A, Murray S, Wang Z, Hui L, Toews GB, Krebsbach PH, Peters-Golden M, Pinsky DJ, Martinez FJ, Thannickal VJ. Evidence for Tissue-Resident Mesenchymal Stem Cells in Human Adult Lung from Studies of Transplanted Allografts. J Clin Invest 2007; 117(4):989-996, PMCID: PMC1810571
146. Wenzel S, Busse W, Calhoun W, Panettieri Jr. R, Peters-Golden M, Dube L, Walton-Bowen K, Russel H, Harris J. The safety and efficacy of zileuton controlled-release (CR) tablets as adjunctive therapy to usual care (UC) in the treatment of moderate persistent asthma. J Asthma 2007; 44(4):305-310, PMID:17530230
147. Brock TG, Peters-Golden M. Activation and regulation of cellular eicosanoid biosynthesis. ScientificWorldJournal 2007; 7:1273-84, PMID: 17767350
148. Thomas PE, Peters-Golden M, White ES, Moore BB. PGE2 inhibition of TGF-β1-induced myofibroblast differentiation is SMAD-independent but involves cell shape and adhesion-dependent signaling. Am J Physiol Lung Cell Mol Physiol 2007; 293(2):L417-28, PMCID: PMC2846428, NIHMS170131
149. Peres CM, Aronoff DM, Serezani CH, Flamand N, Faccioli LH, Peters-Golden M. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. J Immunol 2007; 179:5454-61, PMID: 17911632
150. Serezani CH, Chung J, Ballinger MN, Moore BB, Aronoff DM, Peters-Golden M. Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by E prostanoid receptor 2/4-mediated inhibition of NADPH oxidase activation. Am J Respir Cell Mol Biol 2007; 37(5):562-70, PMCID: PMC2048683
151. Peters-Golden M, Henderson WR, Jr. Leukotrienes. N Engl J Med 2007; 357(18):1841-1854.
152. Coffey MJ, Serezani CH, Phare SM, Peters-Golden M. NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis. J Leukoc Biol 2007; 82(6):1585-91, PMID: 17761955
153. Vannella KM, McMillan TR, Charbeneau RP, Wilke CA, Toews GB, Peters-Golden M, Moore BB. Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function. J Immunol 2007; 179(11):7883-90, PMID: 18025235
154. Canetti C, Serezani CH, Atrasz RG, White ES, Aronoff DM, Peters-Golden M. Activation of phosphatase and tensin homologue on chromosome 10 (PTEN) mediates the inhibition of Fcγ receptor phagocytosis by prostaglandin E2 in alveolar macrophages. J Immunol 2007; 179(12):8350-6, PMID: 18056380
155. Huang SK, Wettlaufer SH, Hogaboam C, Flaherty KR, Martinez FJ, Myers JL, Colby TV, Travis WD, Toews GB, Peters-Golden M. Variable resistance to prostaglandin E2 suppression in lung fibroblasts from patients with usual interstitial pneumonia. Am J Respir Crit Care Med 2008; 177(1):66-74, PMCID: PMC2176116
156. Grishina Z, Pushkareva M, Pletyushkina O, Reiser G, Peters-Golden M, Sud’ina G. Sulfatides inhibit leukotriene synthesis in human polymorphonuclear granulocytes by a mechanism involving lipid rearrangement in intracellular membranes. Int J Biochem Cell Biol 2008; 40(1):110-24, PMID: 17822942
157. Brock TG, Serezani CH, Carstens JK, Peters-Golden M, Aronoff DM. Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fc gamma receptor-mediated phagocytosis in alveolar macrophages. Exp Cell Res 2008; 314(2):255-63, PMCID: PMC 2390918
158. Aronoff DM, Serezani CH, Carstens JK, Marshall T, Gangireddy SR, Peters-Golden M, Reddy RC. Stimulatory effects of peroxisome proliferator-activated receptor-γ on Fcγ receptor-mediated phagocytosis by alveolar macrophages. PPAR Res 2007; 2007:1-8, PMCID: PMC2220046
159. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA. Prostaglandin E2 mediates IL-1β-related fibroblast mitogenic effects in acute lung injury through differential utnlization of prostanoid receptors. J Immunol 2008; 180(1):637-46, PMCID: PMC2789491
160. Aronoff DM, Hao Y, Chung J, Coleman N, Lewis C, Peres CM, Serezani CH, Chen G-H, Flamand N, Brock TG, Peters-Golden M. Misoprostol impairs female reproductive tract innate immunity against Colstridium sordellii. J Immunol 2008; 180(12):8222-30, PMCID: PMC2667109
161. Huang SK, Peters-Golden M. Eicosanoid lipid mediators in fibrotic lung diseases: ready for prime time? Chest 2008; 133(6):1442-50, PMCID: PMC2582216
162. Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M. Cyclic AMP: master regulator of innate immune cell function. Am J Respir Cell Mol Biol 2008; 39(2)127-32, PMCID: PMC272142
163. Peters-Golden M. Expanding roles for leukotrienes in airway inflammation. Curr Allergy Asthma Reports 2008; 8(4):367-73, PMID: 18606091
164. Coffey MJ, Phare SM, Peters-Golden M. Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in alveolar macrophages. Biochim Biophys Acta 2008; 1781(6-7):299-305, PMID: 18474265, NIHMS57223
165. Ballinger M, Hubbard L, McMillan T, Toews G, Peters-Golden M, Paine R, Moore B. Paradoxical role of alveolar macrophage-derived granulocyte macrophage colony stimulating factor in pulmonary host defense post-bone marrow transplantation. Am J Physiol Lung Cell Mol Physiol 2008; 295(1):L114-22, PMCID: PMC2494794
166. Huang SK, Wettlaufer SH, Chung J, Peters-Golden M. Prostaglandin E2 inhibits lung fibroblast proliferation and collagen expression via distinct cAMP effector pathways: differential roles of PKA and Epac-1. Am J Respir Cell Mol Biol 2008; 39(4):482-9, PMCID: PMC 2551707
167. Jarvinen L, Badri L, Wettlaufer S, Ohtsuka T, Pinsky DJ, Toews GB, Peters-Golden M, Lama VN. Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol 2008; 181(6):4389-96, PMID: 18768898, NIHMS384498
168. Weinlich R, Bortoluck KR, Chehab CF, Serezani CH, Ulbrich AG, Peters-Golden M, Russo M, Amarante-Mendes GP. TLR4/MYD88-dependent, LPS-induced synthesis of PGE2 by macrophages or dendritic cells prevents anti-CD3-mediated CD95L upregulation in T cells. Cell Death Differentiation 2008; 15(12):1901-9, PMID: 18820644
169. Chung J, Serezani CH, Huang SK, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M. Rap1 activation is required for Fcγ receptor-dependent phagocytosis. J Immunol 2008; 181(8):5501-9, PMCID: PMC3077557
170. Nair P, Radford K, Fanat A, Janssen LJ, Peters-Golden M, Cox PG. The effects of leptin on airway smooth muscle responses. Am J Respir Cell Mol Biol 2008; 39(4):475-81, PMID: 18421018
171. Lee SP, Serezani CH, Ballinger MN, Medeiros A, Peters-Golden M. Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. J Immunol 2009; 182(1):530-7, PMID: 19109185
172. Flamand N, Luo M, Peters-Golden M, Brock TG. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. J Biol Chem 2009; 284(1):306-13, PMCID: PMC2610501
173. Campos MRM, Serezani CH, Peters-Golden M, Jancar S. Differential kinase requirement for enhancement of FcγR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. Molec Immunol 2009; 46(6):1204-11, PMID: 19223078
174. Medeiros AI, Serezani CH, Lee SP, Peters-Golden M. Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. J Exp Med 2009; 206(1):61-8, PMCID: PMC2626688
175. Peters-Golden M. Putting on the brakes: cyclic AMP as a multipronged controller of macrophage activation. Perspective. Sci Signal 2009; 2(75)::pe37, PMID: 19531801
176. Aronoff DM, Lewis C, Serezani CH, Eaton KA, Phipps JJ, Peters-Golden M, Mancuso P. E prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J Immunol 2009; 183(4):2642-9, PMID: 19635910
177. Huang SK, White ES, Wettlaufer SH, Grifka H, Hogaboam CM, Thannickal VJ, Horowitz JC, Peters-Golden M. Prostaglandin E2 induces fibroblast apoptosis by modulating multiple survival pathways. FASEB J 2009; 23(12):4317-26, PMCID: PMC2812040
178. Serezani CH, Aronoff DM, Sitrin RG, Peters-Golden M. FcγRI ligation leads to a complex with BLT1 in lipid rafts that enhances lung macrophage antimicrobial functions. Blood 2009; 114(15):3316-24, PMCID: PMC2759654
179. Sagana RL, Yan M, Cornett AM, Tsui JL, Stephenson DA, Huang SK, Moore BB, Ballinger MN, Aronoff DA, Peters-Golden M, White ES. Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. J Biol Chem 2009; 284(47):32264-71, PMCID:PMC2781639
180. Costa MF, de Souza-Martins R, de Souza MC, Benjamim CF, Piva B, Diaz BL, Peters-Golden M, Henriques MG, Canetti C, Penido C. Leukotriene B4 mediates γδ T lymphocyte migration in response to diverse stimuli. J Leukoc Biol 2010; 87(2):323-32, PMID: 19880577
181. Mancuso P, Lewis C, Serezani CH, Goel D, Peters-Golden M. Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia. Infect Immun. 2010, 78(5): 2264-71, PMCID: PMC2863513
182. Horowitz JC, Peters-Golden M. Prostaglandin E2's new trick: "decider" of differential alveolar cell life and death. Editorial. Am J Respir Crit Care Med 2010; 182:2-3, PMID: 20601589
183. Bauman KA, Wettlaufer SH, Okunishi K, Vannella KM, Stoolman JS, Huang SK, Courey AJ, White ES, Hogaboam CM, Simon RH, Toews GB, Sisson TH, Moore BB, and Peters-Golden M. The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice. J Clin Invest 2010; 120(6):1950-60, PMCID: PMC2877926
184. Narala VR, Adapala RK, Brock TG, Peters-Golden M, Reddy RC. LTB4 is a physiologically relevant endogenous peroxisome proliferators-activated receptor-α agonist. J Biol Chem 2010; 285(29):22067-74, PMCID: PMC2903376
185. Zhu L, Maruvada R, Sapirstein A, Malik KU, Peters-Golden M, Kim KS. Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier. Infect Immun 2010; 78(10):4302-10, PMCID: PMC2950368
186. Huang SK, Fisher AS, Scruggs AM, White ES, Hogaboam CM, Richardson BC, Peters-Golden M. Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice. Am J Pathol 2010; 177(5):2245-55, PMCID: PMC2966784
187. Montuschi P, Peters-Golden M. Leukotriene modifiers for asthma treatment. Clin Exp Allergy 2010; 40: (12)1732-41, PMID: 21059119
188. Ballinger MN, Welliver T, Straight S, Peters-Golden M, Swanson JA. Transient increase in cyclic AMP localized to macrophage phagosomes. PLOS One 2010; 5(11):e13962, PMID: 21055604
189. Mancuso P, Peters-Golden M, Goel D, Goldberg J, Brock TG, Myers MG, Jr. Deletion of leptin receptor mediated STAT3 signaling enhances pulmonary host defense against pneumococcal pneumonia. J Immunol 2011; 186(2):1081-90, PMCID: PMC3133444
190. Serezani CH, Lewis C, Jancar S, Peters-Golden M. Leukotriene B4 amplifies NFκB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. J Clin Invest 2011; 121(2):671-82, PMCID: PMC3026722
191. Kim S-H, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M. Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of toll-like receptor signaling in alveolar macrophages. J Biol Chem 2011; 286(11):8875-83, PMCID: PMC3058957
192. Badri L, Walker NM, Ohtsuka T, Wang Z, Delmar M, Flint A, Peters-Golden A, Toews GB, Pinsky DJ, Krebsbach PH, Lama VN. Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells. Am J Respir Cell Mol Biol 2011; 45(4):809-16, PMCID: PMC3208618
193. Okunishi K, Peters-Golden M. Leukotrienes and airway inflammation. Biochim Biophys Acta 2011; 1810(11):1096-102, PMCID: PMC3136588
194. Walker N, Badri L, Wettlaufer S, Flint A, Krebsbach PH, Keshamouni VG, Peters-Golden M, Lama VN. Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts. Am J Pathol 2011; 178(6):2461-9, PMCID: PMC3124120
195. Monteiro APT, Pinheiro CS, Luna-Gomes T, Alves LR, Maya-Monteiro CM, Porto BN, Barja-Fidalgo C, Benjamim CF, Peters-Golden M, Bandeira-Melo C, Bozza MT, and Canetti C. Leukotriene B4 mediates neutrophil migration induced by heme. J Immunol 2011; 186(11):6562-7, PMID: 21536805
196. Peres-Buzalaf C, de Paula L, Frantz FG, Soares EM, Medeiros AI, Peters-Golden M, Silva CL, Faccioli LH. Control of experimental pulmonary tuberculosis depends more on immunostimulatory leukotrienes than on the absence of immunosuppressive prostaglandins. Prostaglandins Leukotrienes Essential Fatty Acids 2011; 85(2):75-81. PMCID: PMC3397385, NIHMS387547
197. Morato-Marques M, Campos MM, Kane S, Rangel AP, Lewis C, Ballinger MN, Kim S-H, Peters-Golden M, Jancar S, Serezani CH. Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity. J Biol Chem 2011; 286(33):28902-13, PMCID: PMC3190697
198. Okunishi K, Sisson TH, Huang SK, Hogaboam CM, Simon RH, Peters-Golden. Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts. J Biol Chem. 2011, 286: 32231-43. Epub 2011 Jul 27. PMCID: PMC3173171.
199. Stumm CL, Wettlaufer SH, Jancar S, Peters-Golden M. Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2011; 301(5):L636-44, PMCID: PMC3213985
200. Ballinger MN, Peters-Golden M, Moore BB. Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2. Respir Res 2011;12:155. PMCID: PMC3287971
201. Walker NM, Badri LN, Wadhwa A, Wettlaufer S, Peters-Golden M, Lama VN. Prostaglandin E2 as an inhibitory modulator of fibrogenesis in human lung allografts. Am J Respir Crit Care Med 2012; 185(1):77-84, PMID: PMC3262036
202. Zasłona Z, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M. Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling. Blood 2012; 119(10):2358-67, PMCID: PMC3311259
203. Serezani CH, Medeiros AI, Kane S, Kim SH, Marques MM, Lee SP, Lewis Cornett CA, Bourdonnay E, Ballinger MN, White ES, Peters-Golden M. PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi. Sci Signal 2012; 7(210):ra12, PMCID: PMC3400468, NIHMS385040
204. Aronoff DM, Bergin IL, Lewis C, Goel G, O'Brien E, Serezani CH, Peters-Golden M, Mancuso P. E-Prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae. Prostaglandins Other Lipid Mediators 2012; 98(1-2):23-30, PMCID: PMC3350638, NIHMS368166
205. Bourdonnay E, Serezani CH, Aronoff DM, Peters-Golden M. Regulation of alveolar macrophage phagocyte oxidase through its carrier protein p40phox: hierarchy of activating kinases and their inhibition by prostaglandin E2. J Leukoc Biol. 2012; 92(92):219-31, PMCID: PMC3382311
206. Serezani CH, Kane S, Collins L, Morato-Marques M, Osterholzer JJ, Peters-Golden M. Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. J Immunol. 2012; 189:(2)906-15, PMCID: PMC3392366, NIHMS378651
207. Mancuso P, Myers MJ, Jr., Goel D, Serezani CH, O’Brien E, Goldberg J, Aronoff DM, Peters-Golden M. Ablation of leptin receptor mediated extracellular regulated kinase activation impairs host defense against Gram-negative pneumonia. J Immunol. 2012; 189(2):867-75, PMCID: PMC3392451, NIHMS377212
208. Huang SK, Scruggs AM, Donaghy J, McEakin R, Fisher AS, Richardson BC, Peters-Golden M. Prostaglandin E2 increases gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB J. 2012; 26(9):3703-14, PMCID: PMC3425823
209. Peters-Golden M, Klinger JR, Carson SS. The case for increased funding for research in pulmonary and critical care. Am J Respir Crit Care Med. 2012;186(3):213-5, PMID 22582163
210. Kaul V, Bhattacharya D, Singh Y, Van Kaer L, Peters-Golden M, Bishai WR, Das G. An important role of prostanoid receptor EP2 in host resistance to Mycobacterium tuberculosis infection in mice. J Infect Dis. 2012;206(12):18186-25, PMCID: PMC3502376
211. Zaslona Z, Peters-Golden M. A lipid mediator controls neutrophil recruitment in acute lung injury – should we really be surprised? Crit Care. 2012;16(5):161, PMID: 23102473
212. Brogliato AR, Antunes CA, Carvalho RS, Monteiro APT, Bozza MT, Canetti C, Peters-Golden M, Kunkel SL, Vianna-Jorge R, Benjamim CF. Ketoprofen reverses immunosuppression induced by severe sepsis and reveals an important role for prostaglandin E2. Shock. 2012;38(6):620-629, PMID: 23143054
213. Garrison G, Huang SK, Okunishi K, Scott J, Penke LRK, Scruggs AM, Peters-Golden M. Reversal of myofibroblast differentiation by prostaglandin E2. Am J Respir Cell Mol Biol. In press.
214. Mor-Vaknin N, Legendre M, Yu Y, Serezani CHC, Garg S, Jatzek A, Swanson MD, Teitz-Tennenbaum S, Punturieri A, Engleberg NC, Banerjee R, Kao J, Peters-Golden M, Markovitz DM. Murine colitis is mediated by vimentin. Sci Rep. In press.
215. Scott JP, Peters-Golden M. Anti-leukotriene agents for the treatment of lung disease. Invited review, Am J Respir Crit Care Med. [Submitted]
216. Tian W, Jiang X, Tamosiuniene R, Sung YK, Dhillon G, Gera L, Farkas L, Rabinovitch M, Manickam S, Fridlib M, Rajadas J, Peters-Golden M, Voelkel NF, Nicolls MR. The role of macrophage-derived leukotriene B4 in pulmonary hypertension. [Submitted]
217. Monteiro AP, Soledade E, Pinheiro CS, Dellatorre-Teixeira L, Oliveira GP, Oliveira MG, Peters-Golden M, Rocco PRM, Benjamim CF, Canetti C. Pivotal role of 5-lipoxygenase pathway in lung injury after experimental sepsis. [Submitted]
218. Okunishi K, DeGraaf AJ, Zaslona Z, Peters-Golden M. Inhibition of protein translation as a novel mechanism for prostaglandin E2 regulation of cell functions. [Submitted]
219. Huang SK, Scruggs AM, Donaghy J, Horowitz JC, Zaslona Z, White ES, Peters-Golden M. Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts. [Submitted]
220. Brogliato AR, Moor A, Kesl S, Peters-Golden M, Canetti C, Gould L, Benjamim CF. Critical role of 5-lipoxygenase and heme oxygenase 1 on wound healing. [Submitted]
221. Mason KL, Rogers LM, Soares EM, Bani-Hashemi T, Erb Downward J, Agnew D, Peters-Golden M, Weinberg JB, Crofford LJ, Aronoff DM. Intrauterine group A Streptococcal infections are exacerbated by prostaglandin E2. [Submitted]
222. Zasłona Z, Okunishi K, Domingo-Gonzalez R, Moore BB, Lukacs NW, Aronoff DM, Peters-Golden M. Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells. [Submitted]
Chapters in Books:
1. Brock TG, Peters-Golden M: Localization of 5-lipoxygenase to the nucleus of resting rat basophilic leukemia cells. In: Samuelsson B, Paoletti R, Ramwell P (eds): Ninth International Congress on Prostaglandins and Related Compounds, 1994; 23:151-153
2. Peters-Golden M. Lipid mediators synthesis by lung macrophages. In: Lipscomb MF, Russell S (eds): Lung Macrophages and Dendritic Cells in Health and Disease. Marcel Dekker, Inc., New York, NY, 1997, pp. 151-182
3. Peters-Golden M. Intracellular localization of eicosanoid-forming enzymes. In: Szczeklik A, Gryglewski R, Vane JR (eds): Eicosanoids, Aspirin and Asthma. Marcel Dekker, Inc., New York, NY, 1998, pp. 91-109
4. Peters-Golden M. Molecular mechanism of leukotriene synthesis: The changing paradigm. In: Rodger I, Botting J, Dahlen S-E (eds): Leukotrienes: New Concepts and Targets for Therapy. Kluwer Academic Publisher, Boston, 1998, pp. 1-9.
5. Peters-Golden M, Standiford T. Antimicrobial defense capabilities of the lung. In: Emerging Therapeutic Targets. Vol. 2(1) P Smith, P Warne (eds), Ashley Publications, London, UK, 1998, pp. 15-18
6. Peters-Golden M. Pulmonary diseases other than asthma as potential targets for anti-leukotriene therapy. In: Simon RA and Wenzel SE (eds): Clinical Reviews in Allergy and Immunology. Humana Press, Totowa, NJ, 1999, pp. 247-260
7. Peters-Golden M, Coffey M. Role of leukotrienes in antimicrobial host defense of the lung. In: Simon RA and Wenzel SE (eds): Clinical Reviews in Allergy and Immunology. Humana Press, Totowa, NJ, 1999, pp. 261-269
8. Peters-Golden M, Brock TG. 5-Lipoxygenase and the nucleus: where, when how, and why? In: Paoletti R and Samuelsson B (eds): Advances in Prostaglandin and Leukotriene Research. Kluwer Academic Publishers, Dordrecht, The Netherlands, 2001, pp. 9-15
9. Peters-Golden M. Eicosanoids as mediators and therapeutic targets in airway inflammation. In: Eissa NT and Huston D (eds): Therapeutic Targets of Airway Inflammation. Marcel Dekker, Inc., New York, NY, 2003, pp. 627-656
10. Peters-Golden M. Arachidonic acid metabolites: potential mediators and therapeutic targets in pulmonary fibrosis. In: Lynch JP III (ed): Idiopathic Pulmonary Fibrosis. Marcel Dekker, Inc., New York, NY, 2004, pp. 419-449
11. Peters-Golden M. Lipid mediators: overview. In: Laurent GJ and Shapiro SD (eds): Encyclopedia of Respiratory Medicine. Elsevier Ltd, Oxford, UK, ISBN (Set): 0-12-438360-2, 2006, pp.572-579.
12. Peters-Golden M. Prostaglandins. In: Laurent GJ and Shapiro SD (eds): Encyclopedia of Respiratory Medicine. Elsevier Ltd, Oxford, UK, ISBN (Set): 0-12-438360-2, 2006, pp. 584-588
13. Bone-Larson, C, Peters-Golden, M. Agents affecting the 5-lipoxygenase pathway in treatment of asthma. UpToDate. 2007
14. Peters-Golden M. Pneumonia. In: Schraufnagel D (ed): Respiratory Disease in America. 2010.
15. Okunishi K and Peters-Golden M. Leukotrienes. In: Holgate S, Wills-Karp M, and Izuhara K (eds): Inflammation and Allergy Drug Design. Blackwell Publishing Ltd, Oxford, UK.
16. Peters-Golden M. Slow contractions and rapid progress: the leukotriene story. In: Sheikh A, Platts-Mills T, Worth A, Holgate S (eds): Landmark Papers in Allergy: Seminal Papers in Allergy with Expert Commentaries. Oxford University Press, Oxford, UK. In press
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