原 著・論 文 2002 Takayanagi H, Kim S, Koga T, Nishina H ...



論文業績（英文のみ2006年～2011年）

2006年

1. Anamizu Y, Seichi A, Tsuzuki N, Nakamura K. Age-related changes in histogram pattern of anterior horn cells in human cervical spinal cord. Neuropathology 2006; 26: 533-539.

2. Fukui N, Ikeda Y, Ohnuki T, Hikita A, Tanaka S, Yamane S, Suzuki R, Sandell JL, Ochi T. Pro-inflammatory cytokine TNF-alpha induces BMP-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation. J Biol Chem 2006; 281:27229-27241

3. Hikita A, Yana I, Wakeyama H, Nakamura M, Kadono Y, Oshima Y, Nakamura K, Seiki M, Tanaka S. Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand. J Biol Chem 2006; 281: 36846-36855.

4. Hiraki S, Nakamura I, Okazaki H, Nakamura K, Kurokawa T. Skin behavior during leg lengthening in patients with achondroplasia and hypochondroplasia: a short-term observation during leg lengthening. J Orthop Sci 2006; 11: 267-271.

5. Hiraoka H, Kuribayashi S, Fukuda A, Fukui N, Nakamura K. Endoscopic anterior cruciate ligament reconstruction using a computer-assisted fluoroscopic navigation system. J Orthop Sci 2006; 11: 159-166.

6. Horikoshi T, Maeda K, Kawaguchi Y, Chiba K, Mori K, Koshizuka Y, Hirabayashi S, Sugimori K, Matsumoto M, Kawaguchi H, Takahashi M, Inoue H, Kimura T, Matsusue Y, Inoue I, Baba H, Nakamura K, Ikegawa S. A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine. Hum Genet 2006; 119: 611-616.

7. Hoshikawa A, Nakayama Y, Matsuda T, Oda H, Nakamura K, Mabuchi K . Encapsulation of chondrocytes in photopolymerizable styrenated gelatin for cartilage tissue engineering.　Tissue Eng 2006; 12: 2333-2341.

8. Imai K, Ohnishi I, Bessho M, Nakamura K. Nonlinear finite element model predicts vertebral bone strength and fracture site. Spine 2006; 31:1789-94

9. Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung UI, Kawaguchi H. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Runx2 contributes to pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 2006; 54: 2462-2470

10. Katagiri M, Ogasawara T, Hoshi K, Chikazu D, Kimoto A, Noguchi M, Sasamata M, Harada S, Akama H, Tazaki H, Chung UI, Takato T, Nakamura K, Kawaguchi H. Suppression of adjuvant-induced arthritic bone destruction by cyclooxygenase-2 selective agents with and without inhibitory potency against carbonic anhydrase II. J Bone Miner Res 2006; 21: 219-227.

11. Kawaguchi H. Molecular backgrounds of age-related osteoporosis from mouse genetics approaches. Rev Endocr Metab Disord 2006; 7: 17-22.

12. Koshizuka Y, Ogata N, Shiraki M, Hosoi T, Seichi A, Takeshita K, Nakamura K, and Kawaguchi H: Distinct association of gene polymorphisms of estrogen receptor and vitamin D receptor with lumbar spondylosis in postmenopausal women. Eur Spine J 2006; 15: 1521-1528.

13. Koyama Y, Miyashita M, Kazuma K, Suzukamo Y, Yamamoto M, Karita T, Takatori Y. Preparing a version of the Nottingham adjustment scale (for psychological adjustment) tailored to osteoarthritis of the hip. J Orthop Sci 2006; 11: 359-64.

14. Kugimiya F, Ohba S, Nakamura K, Kawaguchi H, Chung UI. Physiological role of bone morphogenetic proteins in osteogenesis. J Bone Miner Metab 2006; 24: 95-99.

15. Mabuchi A, Nakamura S, Takatori Y, Ikegawa S. Familial osteoarthritis of the hip joint associated with acetabular dysplasia maps to chromosome 13q. Am J Human Genet 2006; 79: 163-168.

16. Maruyama T, Kitagawa T, Takeshita K, Seichi A, Kojima T, Nakamura, Kurokawa T. Fusionless surgery for scoliosis: 2-17 year radiographic and clinical follow-up. Spine 2006; 31: 2310-2315.

17. Maruyama T, Takeshita K, Seichi A, Kitagawa T, Kojima T, Nakamura K, Kurokawa T. Multiple vertebral wedge osteotomy for adolescent idiopathic scoliosis. Stud Health Technol Inform 2006; 123: 283-8.

18. Matsuyama J, Ohnishi I, Sakai R, Suzuki H, Harada A, Bessho M, Matsumoto T, Nakamura K. A new method for measurement of bone deformation by echo tracking. Med Eng Phys 2006; 28: 588-595.

19. Miyazaki T, Tanaka S, Sanjay A, Baron R. The role of c-Src kinase in the regulation of osteoclast function. Mod Rheumatol 2006; 16:68-74.

20. Moro T, Takatori Y, Ishihara K, Nakamura K, Kawaguchi H. Grafting of biocompatible polymer for longevity of artificial hip joints. Clin Orthop Rel Res 2006; 453: 58-63.

21. Muraki S, Yamamoto S, Ishibashi H, Nakamura K. Factors associated with mortality following hip fracture in Japan. J Bone Miner Metab 2006; 24:100-4.

22. Nakagawa T, Hiraoka H, Fukuda A, Matsubara T, Nakayama S, Nakamura K. Symptomatic cyclops lesion after rupture of the anteromedial bundle of the anterior cruciate ligament. J Orthop Sci 11: 537-540, 2006

23. Nakamura K. Professor Yoshinori Tashiro's contribution to orthopedic surgery. J Orthop Sci 2006; 11: 115-117.

24. Oda H, Nakamura K, Matsushita T, Yamamoto S, Ishibashi H, Yamazaki T, Morimoto S. Clinical use of a newly developed calcium phosphate cement (XSB-671D). J Orthop Sci 2006; 11: 167-174.

25. Ogata T, Yamamoto S, Nakamura K and Tanaka S. Signaling Axis in Proliferation and Differentiation of Schwann Cell. Mol Neurobiol. 2006; 33:51-62.

26. Ogihara S, Seichi A, Hozumi T, Oka H, Ieki R, Nakamura K, Kondoh T. Prognostic factors for patients with spinal metastases from lung cancer. Spine 2006; 31:1585-1590.

27. Ohori Y, Yamamoto S, Nagao M, Sugimori M, Yamamoto N, Nakamura K, Nakafuku M. Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord. J Neurosci 2006; 26: 11948-11960.

28. Oka H, Kondoh T, Seichi A, Hozumi T, Nakamura K. Incidence and prognostic factors of Japanese breast cancer patients with bone metastasis. J Orthop Sci　2006, 11: 13-19

29. Oka H, Yoshimura N, Kinoshita H, Saiga A, Kawaguchi H, Nakamura K. Decreased activities of daily living and associations with bone loss among aged residents in a rural Japanese community: the Miyama Study. J Bone Miner Metab 2006; 24: 307-313.

30. Oshima Y, Okutsu I, Hamanaka I, Motomura T. Carpal tunnel syndrome accompanying radial dysplasia due to thalidomide embryopathy. J Hand Surg [Br] 2006; 31 :342-344.

31. Saito T, Kondo T, Hozumi T, Karasawa k, Seichi A, Nakamura K: Results of posterior surgery with intraoperative radiotherapy for spinal metastases. Eur Spine J 2006, 15: 216-222.

32. Sakanishi H, Hoshi K, Nakajima S, Akune T, Takeshita K, Yamamoto M, Kawaguchi H, Nakamura K, Seichi A. Vertebral hemangioma compressing the thoracic spinal cord. J Orthop Sci 2006; 11: 294-297.

33. Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S, Iwakura Y, Cua DJ, Takayanagi H. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006; 203:2673-2682.

34. Sawada Y, Tamada M, Dubin-Thaler BJ, Cherniavskaya O, Sakai R, Tanaka S, Sheetz MP. Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas. Cell 2006; 127:1015-1026.

35. Seichi A, Takeshita K, Kawaguchi H, Matsudaira K, Higashikawa A, Ogata N, Nakamura K. Neurologic level diagnosis of cervical stenotic myelopathy. Spine 2006; 31: 1338-1343.

36. Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, Terauchi Y, Kadowaki T, Takeuchi Y, Fukumoto S, Ikeda T, Hoshi K, Chung UI, Nakamura K, Kawaguchi H. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2006; 196-208.

37. Takeshita K, Lenke L, Bridwell K, Kim YJ, Sides B, Hensley M. Analysis of patients with nonambulatory neuromuscular scoliosis patients surgically treated to the pelvis with intraoperative Halo-femoral traction. Spine 2006; 31: 2381-5.

38. Takeshita K, Maruyama T, Matsudaira K, Murakami M, Higashikawa A, Nakamura K. Validity and reliability of SRSI and SF-36 in Japanese patients with scoliosis. Stud Health Technol Inform. 2006; 123: 337-42.

39. Takeshita K, Maruyama T, Murakami M, Higashikawa A, Hashimoto H, Hara N, Seichi A. Nakamura K. Correction of scoliosis using segmental pedicle screw instrumentation versus hybrid constructs with hooks and screws. Res Spinal Deform 2006; 5: 571-573.

40. Takeshita K, Maruyama T, Murakami M, Higashikawa A, Hashimoto H, Hara N, Seichi A, Nakamura K. Correction of scoliosis using segmental pedicle screw instrumentation versus hybrid constructs with hooks and screws. Stud Health Technol Inform 2006; 123: 571-6.

41. Tanaka S, Suzuki H, Yamauchi H, Nakamura I and Nakamura K. Signal transduction pathways of calcitonin/calcitonin receptor regulating cytoskeletal organization and bone-resorbing activity of osteoclasts. Cell Mol Biol 2006; 52: 19-23.

42. Yamada T, Kawano H, Koshizuka Y, Fukuda T, Yoshimura K, Kamekura S, Saito T, Ikeda T, Kawasaki Y, Azuma Y, Ikegawa S, Hoshi K, Chung UI, Nakamura K, Kato S, and Kawaguchi H: Carminerin contributes to chondrocyte calcification during endochondral ossification. Nat Med 12: 665-670, 2006.

43. Yamaoka H, Asato H, Ogasawara T, Nishizawa S, Takahashi T, Nakatsuka T, Koshima I, Nakamura K, Kawaguchi H, Chung UI, Takato T, Hoshi K. Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials. J Biomed Mater Res A 2006; 78: 1-11.

44. Yoshimura N, Kinoshita H, Hori N, Nishioka T, Ryujin M, Mantani Y, Miyake M, Takeshita T, Ichinose M, Yoshida M, Oka H, Kawaguchi H, Nakamura K, Cooper C. Risk factors for knee osteoarthritis in Japanese men: A case control study. Mod Rheumatol 2006; 16(1): 24-29.

2007年

1. Bessho M, Ohnishi I, Matsuyama J, Matsumoto T, Imai K, Nakamura K. Prediction of strength and strain of the proximal femur by a CT-based finite element method. J Biomech 2007;40: 1745-53.

2. Fijita T, Orimo H, Inoue T, Kaneda K, Sakurai M, Morita R, Yamamoto K, Sugioka Y, Inoue A, Takaoka K, Yamamoto I, Hoshino Y, and Kawaguchi H: Clinical effect of bisphosphonate and vitamin D on osteoporosis: reappraisal of a multicemter double-blind clinical trial comparing etidronate and alfacalcidol. J Bone Miner Metab 2007; 25: 130-137.

3. Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, Seichi A, Shimamura T, Shirado O, Taguchi T, Takahashi K, Takeshita K, Tani T, Toyama Y, Wada E, Yonenobu K, Tanaka T, Hirota Y. Japanese Orthopaedic Association Back Pain Evaluation Questionnaire. Part 2. Verification of its reliability: The Subcommittee on Low Back Pain and Cervical Myelopathy Evaluation of the Clinical Outcome Committee of the Japanese Orthopaedic Association. J Orthop Sci 2007;12:526-32.

4. Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, Seichi A, Shimamura T, Shirado O, Taguchi T, Takahashi K, Takeshita K, Tani T, Toyama Y, Wada E, Yonenobu K, Tanaka T, Hirota Y. JOA Back Pain Evaluation Questionnaire: initial report. J Orthop Sci 2007;12:443-450.

5. Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, Seichi A, Shimamura T, Shirado O, Taguchi T, Takahashi K, Takeshita K, Tani T, Toyama Y, Wada E, Yonenobu K,Tanaka T, Hirota Y. Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 3. Determination of reliability. J Orthop Sci 2007;12:321-326.

6. Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, Seichi A, Shimamura T, Shirado O, Taguchi T, Takahashi K, Takeshita K, Tani T, Toyama Y, Wada E, Yonenobu K,Tanaka T, Hirota Y. Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 2. Endorsement of the alternative item. J Orthop Sci 2007;12:241-248.

7. Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, Seichi A, Shimamura T, Shirado O, Taguchi T, Takahashi K, Takeshita K, Tani T, Toyama Y, Wada E, Yonenobu K,Tanaka T, Hirota Y. An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 1. J Orthop Sci 2007;12:227-240.

8. Hikita A, Tanaka S. Ectodomain shedding of receptor activator of NF-kappaB ligand. Adv Exp Med Biol. 2007;602:15-21.

9. Hiramatsu K, Asaba Y, Takeshita S, Nimura Y, Tatsumi S, Katagiri N, Niida S, Nakajima T, Tanaka S, Ito M, Karsenty G, Ikeda K. Gamma-glutamyltransferase as a pathogenic factor of bone and joint disease. Endocrinology 2007, 48:2708-2715.

10. Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, and Chung UI: Identification and characterization of the human SOX6 promoter. Biochem Biophys Res Commun 2007; 357: 383-390.

11. Itaka K, Ohba S, Miyata K, Kawaguchi H, Nakamura K, Takato T, Chung UI, and Kataoka K: Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol Ther 2007; 15: 1655-1662.

12. Kawaguchi H, Jingushi S, Izumi T, Fukunaga M, Matsushita T, Nakamura T, Mizuno K, Nakamura T, and Nakamura K: Local application of recombinant human fibroblast growth factor-2 on bone repair: a dose-escalation prospective trial on patients with osteotomy. J Orthop Res 2007; 25: 480-487.

13. Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Chen WS, Hay N, Tobe T, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung UI, and Kawaguchi H: Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS ONE 2007; 2: e1058.

14. Kimura M, Konno T, Takai M, Ishiyama N, Moro T, Ishihara K. Prevention of tissue adhesion by a spontaneously formed phospholipid polymer hydrogel. Key Engineering Materials 2007; 342-343: 777-780.

15. Konno S, Hayashino Y, Fukuhara S, Kikuchi S, Kaneda K, Seichi A, Chiba K, Satomi K, Nagata K, Kawai S. Development of a clinical diagnosis support tool to identify patients with lumbar spinal stenosis. Eur Spine J 2007; 16:1951-1957.

16. Kono SJ, Ohshima Y, Hoshi K, Bonewald LF, Oda H, Nakamura K, Kawaguchi H, and Tanaka S: Erk pathways negatively regulate matrix mineralization. Bone 2007; 40: 68-74.

17. Kosaki N, Takaishi H, Kamekura S, Kimura T, Okada Y, Minqi L, Amizuka N, Chung UI, Nakamura K, Kawaguchi H, Toyama Y, and D'Armiento J: Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun 2007; 354: 846-51.

18. Koyama Y, Miyashita M, Irie S, Takatori Y, Yamamoto M, Karita T, Kazuma K. A study of the reality of daily life among patients with osteoarthritis of the hip undergoing conservative treatment. J Orthop Nurs. 2007; 11: 81-90.

19. Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett JR, Nakamura K, and Chung UI: GSK-3β controls osteogenesis through regulating Runx2 activity. PLoS ONE 2007; 2: e837.

20. Kyomoto M, Iwasaki Y, Moro T, Konno T, Miyaji F, Kawaguchi H, Takatori Y, Nakamura K, and Ishihara K: High lubricious surface of cobalt-chromium-molybdenum alloy prepared by grafting poly(2-methacryloyloxyethyl phosphorylcholine). Biomaterials 2007; 28: 3121-3130.

21. Kyomoto M, Iwasaki Y, Moro T, Konno T, Miyaji F, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K. High lubricious surface of cobalt-chromium-molybdenum alloy prepared by grafting poly(2-methacryloyloxyethyl phosphorylcholine). Biomaterials. 2007; 28: 3121-3130.

22. Kyomoto M, Moro T, Konno T, Takadama H, Kawaguchi H, Takatori Y, Nakamura K, Yamawaki N, and Ishihara K: Effects of photo-induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on physical properties of cross-linked polyethylene in artificial hip joints. J Mater Sci Mater M 2007; 18: 1809-1815.

23. Kyomoto M, Moro T, Konno T, Takadama H, Kawaguchi H, Takatori Y, Nakamura K, Yamawaki N, Ishihara K. Effects of photo-induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on physical properties of cross-linked polyethylene in artificial hip joints. J Mater Sci Mater Med. 2007; 18: 1809-1815.

24. Kyomoto M, Moro T, Konno T, Takadama H, Yamawaki N, Kawaguchi H, Takatori Y, Nakamura K, and Ishihara K: Enhanced wear resistance of modified cross-linked polyethylene by grafting with poly (2-methacryloyloxyethyl phosphorylcholine). J Biomed Mater Res A 2007; 82: 10-17.

25. Liu G, Kawaguchi H, Ogasawara T, Asawa Y, Kishimoto JI, Takahashi T, Chung UI, Yamaoka H, Asato H, Nakamura K, Takato T, and Hoshi K: Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes. J Biol Chem 2007; 282: 20407-20415.

26. Maruyama Z, Yoshida CA, Furuichi T, Amizuka N, Ito M, Fukuyama R, Miyazaki T, Kitaura T, Nakamura K, Fujita T, Kanatani N, Moriishi T, Yamana K, Liu W, Kawaguchi H, Nakamura K, and Komori T: Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dynam 2007; 236: 1876-1890.

27. Miyamoto Y, Mabuchi A, Shi D, Kubo T, Takatori Y, Saito S, Fujioka M, Sudo A, Uchida A, Yamamoto S, Ozaki K, Takigawa M, Tanaka T, Nakamura Y, Jiang Q, Ikegawa S. A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet. 2007; 39: 529-533.

28. Muraki S, Yamamoto S, Ishibashi H, Oka H, Yoshimura N, Kawaguchi H, and Nakamura K: Diet and lifestyle associated with increased bone mineral density: cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic. J Orthop Sci 2007; 12: 317-320.

29. Nakagawa T, Hiraoka H, Fukuda A, Kuribayashi S, Nakayama S, Matsubara T, Nakamura K. Fluoroscopic-based navigation-assisted placement of the tibial tunnel in revision anterior cruciate ligament reconstruction. Arthroscopy, 2007;23:443.e1-443.e4

30. Ogata N, Kawaguchi H, Chung UI, Roth SI, and Segre GV: Continuous activation of Gαq in osteoblasts results in osteopenia through impaired osteoblast differentiation. J Biol Chem 2007; 282: 35757-64.

31. Ohashi S, Ohnishi I, Kageyama T, Imai K, Nakamura K. Distraction osteogenesis promotes angiogenesis in the surrounding muscles. Clin Orthop Relat Res. 2007 Jan;454:223-9.

32. Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, and Chung UI: Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor. FASEB J 2007; 21: 1777-1787.

33. Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, and Chung UI: A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun 2007; 357: 854-860.

34. Saito T, Ikeda T, Nakamura K, Chung UI, and Kawaguchi H: S100A1 and B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes. EMBO Rep 2007; 8: 504-509.

35. Shimizu S, Asou Y, Itoh S, Cung UI, Kawaguchi H, Shinomiya K, and Muneta T: Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor / osteoprotegerin in a murine model of osteoarethritis. Arthritis Rheum 2007; 56: 3358-3365.

36. Suematsu A, Tajiri Y, Nakashima T, Taka J, Ochi S, Oda H, Nakamura K, Tanaka S, Takayanagi H. Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis. Mod Rheumatol 2007, 17:17-23.

37. Tanaka S. Signaling axis in osteoclast biology and therapeutic targeting in the RANKL/RANK/OPG system. Am J Nephrol 2007, 27:466-478.

38. Wakeyama H, Akiyama T, Nakamura K, Tanaka S. Posttranslational regulation of Bim by Caspase-3 in the osteoclast. Ann N Y Acad Sci. 2007, 1116:271–280.

39. Wakeyama H, Akiyama T, Takahashi K, Amano H, Kadono Y, Nakamura M, Oshima Y, Itabe H, Nakayama KI, Nakayama K, Nakamura K, Tanaka S. Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts. J Bone Miner Res 2007, 22:1631-1639.

2008年

1. Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, and Kawaguchi H: Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders. Arthritis Rheum 2008; 58: 172-183.

2. Yoshimura N, Kinoshita H, Takijiri T, Oka H, Muraki S, Mabuchi A, Kawaguchi H, Nakamura K, and Nakamura T: Association between height loss and bone loss, cumulative incidence of vertebral fractures and future quality of life: The Miyama Study. Osteoporosis Int 2008; 19: 21-8.

3. Kyomoto M, Moro T, Miyaji F, Konno T, Hashimoto M, Kawaguchi H, Takatori Y, Nakamura K, and Ishihara K: Enhanced wear resistance of orthopaedic bearing due to the cross-linking of poly (MPC) graft chains induced by gamma-ray irradiation. J Biomed Mater Res B 2008; 84: 320-327.

4. Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Kawaguchi H, Ohba S, Chung UI, and Choi JY: Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator. Gene 2008; 416: 53-60.

5. Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, and Chung UI: Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell 2008; 14: 689-699.

6. Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, and Kawaguchi H: Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. J Clin Invest 2008; 118: 2506-2515.

7. Kyomoto M, Moro T, Miyaji F, Hashimoto M, Kawaguchi H, Takatori Y, Nakamura K, and Ishihara K: Effect of 2-methacryloyloxyethyl phosphorylcholine concentration on photo-induced graft polymerization of polyethylene in reducing the wear of orthopaedic bearing surface. J Biomed Mater Res A 2008; 86: 439-47.

8. Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, and Takeda S: The Distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: Findings in murine models and in human disease. Arthritis Rheum 2008; 58: 2764-2775.

9. Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, and Kawaguchi H: Krüppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem 2008; 283: 24682-24689.

10. Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H, Yamamoto S, Nakamura K, Yoshimura N, and Kawaguchi H: Fully automatic quantification of knee osteoarthritis severity on plain radiographs. Osteoarthritis Cartilage 2008; 16: 1300-1306.

11. Watanabe T, Sato T, Amano T, Kawamura Y, Kawamura N, Kawaguchi H, Yamashita N, Kurihara H, and Nakaoka T: Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dynam 2008; 237: 3738-3748.

12. Yamashita T, Kobayashi Y, Mizoguchi T, Yamaki M, Miura T, Tanaka S, Udagawa N, Takahashi N. MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts. Biochem Biophys Res Commun 2008; 365:252-257.

13. Koyama Y, Miyashita M, Irie S, Yamamoto M, Karita T, Moro T, Takatori Y, Kazuma K. A study of disease management activities of hip osteoarthritis patients under conservative treatment. J Orthop Nur 2008; 12: 75-83.

14. Ajima R, Akiyama T, Usui M, Yoneda M, Yoshida Y, Nakamura T, Minowa O, Noda M, Tanaka S, Noda T, Yamamoto T. Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett 2008; 582:1313-1318.

15. Okuma-Yoshioka C, Seto H, Kadono Y, Hikita A, Oshima Y, Kurosawa H, Nakamura K, Tanaka S. Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways. Mod Rheumatol 2008; 18:366-378.

16. Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S. Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. J Biol Chem 2008; 283: 26499-26508.

17. Eun-Ju Chang, Jeongim Ha, Frank Oerlemans, You Jin Lee, Soo Woong Lee, Jiyoon Ryu, Hyung Joon Kim, Youngkyun Lee, Hyun-Man Kim, Je-Yong Choi, Jin Young Kim, Chan Soo Shin, Youngmi Kim Pak, Sakae Tanaka, Bé Wieringa, Zang Hee Lee, Hong-Hee Kim. Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption. Nat Med 2008; 14:966-972.

18. Hoshikawa S, Ogata T, Fujiwara S, Nakamura K, Tanaka S.A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells. PLoS ONE 2008; 3:e3464.

19. Okuma C, Kaketa T, Hikita A, Matsuda K, Nakamura M, Nagase Y, Oshima Y, Iwasawa M, Nakamura Y, Kurosawa H, Nakamura K, Tanaka S. Potential involvement of p53 in ischemia/reperfusion-induced osteonecrosis. J Bone Miner Metab 2008; 26:576-585.

20. Imai K, Ohnishi I, Yamamoto S, Nakamura K. In vivo assessment of lumbar vertebral strength in elderly women using CT-based nonlinear finite element model. Spine 2008; 33, 27-32.

21. Matsuyama J, Ohnishi I, Sakai R, Bessho M, Matsumoto T, Miyasaka K, Harada A, Ohashi S, Nakamura K. A new method for evaluation of fracture healing by echo tracking. Ultrasound in Med Biol 2008; 34: 775-783.

22. Joung S, Kamon H, Liao H, Iwaki J, Nakazawa T, Mitsuishi M, Nakajima Y, Koyama T, Sugano N, Maeda Y, Bessho M, Ohashi S, Matsumoto T, Ohnishi I, Sakuma I. A robot assisted hip fracture reduction with a navigation system. Med Image Compu Comput-Ass Interv 2008; : 11: 501-8.

23. Akaha H, Matsudaira K, Takeshita K, Oka H, Hara N, Nakamura K Modified measurement of flexion for lumbar impairment -Self-assessment bending scale-　J Lumbar Spine Disord 2008; 14:164-169

24. Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, Seichi A, Shimamura T, Shirado O, Taguchi T, Takahashi K, Takeshita K, Tani T, Toyama Y, Wada E, Yonenobu K, Tanaka T, Hirota Y. Japanese Orthopaedic Association Back Pain Evaluation Questionnaire. Part 3. Validity study and establishment of the measurement scale: Subcommittee on Low Back Pain and Cervical Myelopathy Evaluation of the Clinical Outcome Committee of the Japanese Orthopaedic Association, Japan.　J Orthop Sci 2008; 13: 173-9.

25. Maruyama T, Takeshita K. Surgical treatment of scoliosis: a review of techniques currently applied. Scoliosis 2008; 3: 6.

26. Matsumoto M, Chiba K, Toyama Y, Takeshita K, Seichi A, Nakamura K, Arimizu J, Fujibayashi S, Hirabayashi S, Hirano T, Iwasaki M, Kaneoka K, Kawaguchi Y, Ijiri K, Maeda T, Matsuyama Y, Mikami Y, Murakami H, Nagashima H, Nagata K, Nakahara S, Nohara Y, Oka S, Sakamoto K, Saruhashi Y, Yutaka Sasao Y, Shimizu K, Taguchi T, Takahashi M, Tanaka Y, Tani T, Tokuhashi Y, Uchida K, Yamamoto K, Yamazaki M, Yokoyama T, Yoshida M, Nishiwaki Y. Surgical Results and Related Factors for Ossification of Posterior Longitudinal Ligament of the Thoracic Spine: A Multi-Institutional Retrospective Study. Spine 2008; 33: 1034-41.

27. Maruyama T, Takeshita K, Kitagawa T. Side-shift exercise and hitch exercise. Stud Health Technol Inform 2008; 135: 246-9.

28. Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, Seichi A, Shimamura T, Shirado O, Taguchi T, Takahashi K, Takeshita K, Tani T, Toyama Y, Yonenobu K, Wada E, Tanaka T, Hirota Y. Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): part 4. Establishment of equations for severity scores: Subcommittee on low back pain and cervical myelopathy, evaluation of the clinical outcome committee of the Japanese Orthopaedic Association. J Orthop Sci 2008;13: 25-31.

29. Akiyama T, Yamamoto A, Kashima T, Ishida T, Shinoda Y, Goto T, Nakamura K, and Kawano H: Juxtacortical chondroma of the sacrum. J Orthop Sci. 2008; 13: 476-80.

30. Matsumoto T, Shiina H, Kawano H, Sato T, and Kato S: Androgen receptor functions in male and female physiology. J Steroid Biochem Mol Biol. 2008; 109: 236-41.

31. Akiyama T, Dass CR, Choong PF: Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway. Mol Cancer Ther. 2008; 7: 3461-9.

32. Miura T, Osuka K, Itoh S, Nakagawa T, Kawano H, Nakamura K: Early functional improvement after a modified ligament reconstruction tendon interposition arthroplasty for thumb basal joint arthritis. Hand Surg. 2008; 3: 153-8.

33. Nakagawa T, Takeda H, Nakajima K, Nakayama S, Fukai A, Kachi Y, Kawano H, Miura T, Nakamura K.　Intraoperative 3-dimensional imaging-based navigation-assisted anatomic double-bundle anterior cruciate ligament reconstruction. Arthroscopy. 2008 ;　24:　1161-7.

2009年

1. Chikuda H, Seichi A, Takeshita K, Shoda N, Ono T, Matsudaira K, Kawaguchi H, and Nakamura K: Radiographic analysis of the cervical spine in patients with retro-odontoid pseudotumors. Spine 2009; 34: E110-114.

2. Goto T, Kawano H, Akiyama T, Shinoda Y, Okuma T, Kobayashi H, Nemoto T, Funata N.: Serum acid phosphatase can be a useful tumour marker for giant cell tumour of bone. Arch Orthop Trauma Surg. 2009; 129(12):1641-4.

3. Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, and Kawaguchi H: Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene. Arthritis Rheum 2009; 60: 166-178.

4. Hikita A, Tanaka N, Yamane S, Ikeda Y, Furukawa H, Tohma S, Suzuki R, Tanaka S, Mitomi H, Fukui N. Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha. Biochem Cell Biol. 2009; 87:581-593.

5. Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, and Kawaguchi H: C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57Kip2. PLoS ONE 2009; 4: e4543.

6. Iwasawa M, Miyazaki T, Nagase Y, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Nakamura T, Kato S, Henninghausen L, Nakamura K, Tanaka S. Negative regulation of bone-resorbing activity of osteoclasts by anti-apoptotic Bcl-xL protein. J Clin Invest 2009; 119:3149-3159.

7. Kadono Y, Tanaka S, Nishino J, Nishimura K, Nakamura I, Miyazaki T, Takayanagi H, Nakamura K. Rheumatoid arthritis associated with osteopetrosis. Mod Rheumatol 2009; 19(6):687-690.

8. Kan A, Ikeda T, Saito T, Yano F, Fukai A, Ogata N, Nakamura K, Chung UI, and Kawaguchi H: Screening of chondrogenic factors by a real-time fluorescence monitoring cell line ATDC5-C2ER: Identification of sorting nexin 19 as a novel factor. Arthritis Rheum 2009; 60: 3314-3323.

9. Kyomoto M, Moro M, Saiga K, Miyaji F, Kawaguchi H, Takatori Y, Nakamura K, and Ishihara K: Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage. Biomaterials 2009; 31: 658-668.

10. Kyomoto M, Moro T, Iwasaki Y, Miyaji F, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K. Superlubricious surface mimicking articular cartilage by grafting poly(2-methacryloyloxyethyl phosphorylcholine) on orthopaedic metal bearings. J Biomed Mater Res A 2009; 91: 730-741.

11. Kyomoto M, Moro T, Miyaji F, Hashimoto M, Kawaguchi H, Takatori Y, Nakamura K, and Ishihara K. Effects of mobility/immobility of surface modification by 2-methacryloyloxyethyl phosphorylcholine polymer on the durability of polyethylene for artificial joints. J Biomed Mater Res A 2009; 90: 362-371.

12. Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara K, Asawa Y, Fujihara Y, Chung UI, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, and Hoshi K: Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates. J Biomed Mater Res A 2009; 92: 1273-1282.

13. Maruyama T, Takeshita K, Kitagawa T, Nakao Y. Does bracing affect the quality of life of patients with adolescent idiopathic scoliosis? Eur Spinal Resonances 2009;16(51): 2250-2251.

14. Maruyama T, Takeshita K, Kitagawa T. Does bracing affect the quality of life of patients with adolescent idiopathic scoliosis? Scoliosis 2009;4(S1):O63.

15. Matsudaira K, Seichi A, Kunogi J, Yamazaki T, Kobayashi A, Anamizu Y, Kishimoto J, Hoshi K, Takeshita K, Nakamura K. The efficacy of prostaglandin E1 derivative in patients with lumbar spinal stenosis Spine 2009；34(2):115-120.

16. Matsudaira K, Yamazaki T, Seichi A, Hoshi K, Hara N, Ogiwara S, Terayama S, Chikuda H, Takeshita K, Nakamura K. Modified fenestration with restorative spinoplasty for lumbar spinal stenosis. Technical note. J Neurosurg Spine 2009;10(6):587-94.

17. Miura T, Tokuyama N, Ohya J: Spontaneous rupture of the flexor digitorum superficialis tendon of the little finger with aplasia of the flexor digitorum profundus tendon. J Hand Surg Eur 2009; 35(3): 238-9.

18. Morioka K, Tanikawa C, Ochi K, Daigo Y, Katagiri T, Kawano H, Kawaguchi H, Myoui A, Yoshikawa H, Naka N, Araki N, Kudawara I, Ieguchi M, Nakamura K, Nakamura Y, and Matsuda K: Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci 2009; 100: 1227-1233.

19. Morizaki Y, Miura T: Unusual pattern of dislocation of the trapeziometacarpal joint with avulsion fracture of the trapezium. Hand Surg 2009; 14(2-3): 149-152.

20. Moro T, Kawaguchi H, Ishihara K, Kyomoto M, Karita T, Ito H, Nakamura K, and Takatori Y: Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine) grafted polyethylene: Comparisons with the effect of polyethylene cross-linking and ceramic femoral heads. Biomaterials 2009; 30: 2995-3001.

21. Muraki S, Akune T, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Nakamura K, Kawaguchi H, and Yoshimura N: Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts: A large-scale population-based study. Arthritis Rheum 2009; 61: 779-786.

22. Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, and Yoshimura N: Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: The ROAD study. Osteoarthritis Cartilage 2009; 17: 1137-1143.

23. Muraki S, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, and Yoshimura N: Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts: the ROAD study. Ann Rheum Dis 2009; 68: 1401-1406.

24. Nagase Y, Iwasawa M, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Hirose J, Nakamura H, Miyamoto T, Bouillet P, Nakamura K, Tanaka S. The anti-apoptotic molecule Bcl-2 regulates the differentiation, activation and survival of both osteoblasts and osteoclasts. J Biol Chem. 2009; 284:36659-36669

25. Nishino J, Tanaka S, Matsui T, Mori T, Nishimura K, Eto Y, Kaneko A, Saisho K, Yasuda M, Chiba N, Yoshinaga Y, Saeki Y, Seki A, Tohma S. Prevalence of joint replacement surgery in rheumatoid arthritis patients: cross-sectional analysis in a large observational cohort in Japan. Mod Rheumatol. 2009; 19:260-264.

26. Oka H, Akune T, Muraki S, Mabuchi A, En-yo Y, Yoshida M, Saika A, Sasaki S, Nakamura K, Kawaguchi H, and Yoshimura N: Low dietary vitamin K intake is associated with radiographic knee osteoarthritis in the Japanese elderly: Dietary survey in a population-based cohort of the ROAD study. J Orthop Sci 2009; 14: 687-692.

27. Ota N, Takaishi H, Kosaki N, Takito J, Yoda M, Tohmonda T, Kimura T, Okada Y, Yasuda H, Kawaguchi H, Matsumoto M, Chiba K, Ikegami H, and Toyama Y: Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice. Endocrinology 2009; 150: 4823-4834.

28. Seichi A, Yuichi Hoshino, Takeshita K, Chikuda H, Nakamura K. Intraoperative ultrasonographic evaluation of posterior decompression of the posterior longitudinal ligament – correlation with two-year follow-up results- J Jap Soc Spine Surg Rel Res 2009;20:617-619.

29. Shoda N, Seichi A, Takeshita K, Chikuda H, Ono T, Oka H, Kawaguchi H, and Nakamura K: Sleep apnea in rheumatoid arthritis patients with occipitocervical lesions: the prevalence and associated radiographic features. Eur Spine J 2009; 18: 905-910.

30. Takeshita K, Maruyama T, Chikuda H, Shoda N, Seichi A, Ono T, Nakamura K. Diameter, Length, and Direction of Pedicle Screws for Scoliotic Spine - Analysis by Multiplanar Reconstruction of Computed Tomography – Spine 2009；34：798-803.

31. Tanaka S, Nishino J, Matsui T, Komiya K, Nishimura K, Tohma S. Neutrophil CD64 expression in the diagnosis of musculoskeletal infection and the impact of antibiotics. J Bone Joint Surg (Br) 2009; 91:1237-1242.

32. Tóth B, Sarang Z, Vereb G, Zhang A, Tanaka S, Melino G, Fésüs L, Szondy Z. Over-expression of integrin beta3 can partially overcome the defect of integrin beta3 signaling in transglutaminase 2 null macrophages. Immunol Lett. 2009; 126:22-28.

33. Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung UI, Nakamura K, and Kawaguchi H: Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells. Osteoarthritis Cartilage 2009; 17: 1065-1075.

34. Yoshimura N, Muraki S, Oka H, Kinoshita H, Yoshida M, Mabuchi A, Kawaguchi H, Nakamura K, and Akune T: Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship – Is osteoarthritis a predictor for osteoporosis or vice versa?: The Miyama study. Osteoporosis Int 2009; 20: 999-1008.

35. Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, Ishibashi H, Kawaguchi H, Nakamura K, Akune T. Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab 2009; 27: 620-628.

2010年

1. Lin L, Bu G, Mars WM, Reeves WB, Tanaka S, Hu K: tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway. Am J Pathol 177: 1687-1696, 2010

2. Nagase Y, Iwasawa M, Akiyama T, Ogata N, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Masuda H, Bouillet P, Nakamura K, Tanaka S: Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in bone. Ann NY Acad Sci 1192: 330-337, 2010

3. Miki Y, Ngan S, Clark JC, Akiyama T, Choong PF: The significance of size change of soft tissue sarcoma during preoperative radiotherapy. Eur J Surg Oncol 36: 678-683, 2010

4. Chikuda H, Seichi A, Takeshita K, Shoda N, Ono T, Matsudaira K, Kawaguchi H, Nakamura K: Correlation between pyramidal signs and the severity of cervical myelopathy. Eur Spine J 19: 1684-1689, 2010

5. Hara N, Oka H, Yamazaki T, Takeshita K, Murakami M, Hoshi K, Terayama S, Seichi A, Nakamura K, Kawaguchi H, Matsudaira K: Predictors of residual symptoms in lower extremities after decompression surgery on lumbar spinal stenosis. Eur Spine J 19: 1849-1854, 2010

6. Hirabayashi S, Yamada H, Motosuneya T, Watanabe Y, Miura M, Sakai H, Matsushita T: Comparison of enlargement of the spinal canal after cervical laminoplasty: open-door type and double-door type. Eur Spine J 19: 1690-1694, 2010

7. Takedani H, Fujii T, Kobayashi Y, Haga N, Tatsunami S, Fujii T: Inter–observer reliability of three different radiographic scores for adult haemophilia. Haemophilia 17: 134-138, 2010

8. Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T: Cohort profile: Research on Osteoarthritis/Osteoporosis Against Disability study. Int J Epidemiol 39: 988-995, 2010

9. Akiyama T, Clark JC, Miki Y, Choong PF: The non-vascularised fibular graft: a simple and successful method of reconstruction of the pelvic ring after internal hemipelvectomy. J Bone Joint Surg Br 92: 999-1005, 2010

10. Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI: Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J Bone Miner Metab 28: 627-633, 2010

11. Kawaguchi H, Oka H, Jingushi S, Izumi T, Fukunaga M, Sato K, Matsushita T, Nakamura K: A local application of recombinant human fibroblast growth factor-2 for tibial shaft fractures: a randomized, placebo-controlled trial. J Bone Miner Res 25: 2459-2467, 2010

12. Nishikawa K, Nakashima T, Takeda S, Isogai M, Hamada M, Kimura A, Kodama T, Yamaguchi A, Owen M J, Takahashi S, Takayanagi H: Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. J Clin Invest 120: 3455-3465, 2010

13. Okutsu I: How I developed the world’s first evidence-based endoscopic management of carpal tunnel syndrome. J Hand Surg 15: 149-155, 2010

14. Yoshida A, Okutsu I, Hamanaka I: A new diagnostic provocation test for carpal tunnel syndrome: Okutsu test. J Hand Surg 15: 65-69, 2010

15. Morizaki Y, Zhao C, An KN, Amadio PC: The effects of platelet-rich plasma on bone marrow stromal cell transplants for tendon healing in vitro. J Hand Surg Am 35: 1833-1841, 2010

16. Goto T, Nemoto T, Ogura K, Hozumi T, Funata N: Successful treatment of desmoid tumor of the chest wall with tranilast: a case report. J Med Case Reports 4: 384, 2010

17. Hiraoka N, Takahashi KA, Arai Y, Sakao K, Mazda O, Kishida T, Honjo K, Tanaka S, Kubo T: Intra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral bone. J Orthop Res 29: 354-360, 2010

18. Kadono Y, Yasunaga H, Horiguchi H, Hashimoto H, Matsuda M, Tanaka S, Nakamura K: Statistics in orthopaedic surgery in 2006-2007: data from the Japanese diagnosis procedure combination (DPC) database. J Orthop Sci 5: 162-170, 2010

19. Nakashima Y, Haga N, Kitoh H, Kamizono J, Tozawa K, Katagiri T, Susami T, Fukushi J, Iwamoto Y: Deformity of the great toe in fibrodysplasia ossificans progressiva. J Orthop Sci 15: 804-809, 2010

20. Nishino J, Tanaka S, Kadono Y, Matsui T, Komiya A, Nishimura K, Tohma S: The usefulness of neutrophil CD64 expression in the diagnosis of local infection in patients with rheumatoid arthritis in daily practice. J Orthop Sci 15: 547-552, 2010

21. Oka H, Muraki S, Akune T, Nakamura K, Kawaguchi H, Yoshimura N: Normal and threshold values of radiographic parameters for knee osteoarthritis using a computer-assisted measuring system (KOACAD): the ROAD study. J Orthop Sci 15: 781-789, 2010

22. Xu Z, Ichikawa N, Kosaki K, Yamada Y, Sasaki T, Sakai LY, Kurosawa H, Hattori N, Arikawa-Hirasawa E: Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition. Matrix Biology 29: 461-470, 2010

23. Doi T, Miyazaki T, Nishino J, Tanaka S, Matsui T, Komiya A, Yamamoto S, Tokimura F, Mori T, Nishimura K, Katho N, Hasegawa J, Omata Y, Matsushita T, Tohma S: Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis. Mod Rheumatol 20: 573-579, 2010

24. Muraki S, Akune T, Oka H, En-Yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N: Impact of knee and low back pain on health-related quality of life in Japanese women: the Research on Osteoarthritis Against Disability (ROAD). Mod Rheumatol 20: 444-451, 2010

25. Yasui T, Nishino J, Kadono Y, Matui T, Nakamura K, Tanaka S, Tohma S: Impact of Biologics on the Prevalence of Orthopaedic Surgery in the National Database of Rheumatic Diseases in Japan. Mod Rheumatol 20: 233-237, 2010

26. Kato M, Takaishi H, Yoda M, Tohmonda T, Takito J, Fujita N, Hosogane N, Horiuchi K, Kimura T, Okada Y, Saito T, Kawaguchi H, Kikuchi T, Matsumoto M, Toyama Y, Chiba K: GRIP1 enhances estrogen receptor α-dependent extracellular matrix gene expression in chondrogenic cells. Osteoarthr Cartilage 18: 934-941, 2010

27. Katsuragawa Y, Saitoh K, Tanaka N, Wake M, Ikeda Y, Furukawa H, Tohma S, Sawabe M, Ishiyama M, Yagishita S, Suzuki R, Mitomi H, Fukui N: Change of human menisci in osteoarthritic knee joints. Osteoarthr Cartilage 18: 1133-1143, 2010

28. Moro T, Takatori Y, Kyomoto M, Ishihara K, Saiga KI, Nakamura K, Kawaguchi H: Surface grafting of biocompatible phospholipid polymer MPC provides wear resistance of tibial polyethylene insert in artificial knee joints. Osteoarthr Cartilage 18: 1174-1182, 2010

29. Muraki S, Akune T, Oka H, En-Yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N: Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: The ROAD study. Osteoarthr Cartilage 18: 1227-1234, 2010

2011年

1. Nakagawa K, Ohkuma K, Yamashita H, Masuda M, Matsumoto Y, Goto T: Radiation therapy did not alleviate complete paralysis due to metastasis of lung adenocarcinoma to thoracic vertebrae until four months later. Acta Oncologica 50: 606-608, 2011

2. Evangelou E, Valdes AM, Kerkhof H, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories R, Karassa F, Tylzanowski P, DaniBos S, Akune T, Arden N, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart D, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Klop M, Kujala O, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson P, Nishida N, Ollier W, Panoutsopoulou K, van Depute T, Ralston S, Rivadeneira F, Saarela J, Schulte-Merker S, Slagboom PE, Sudo A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis G, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden A, Felson D, van Meurs JB, Stefansson K, Ioannidis J, Spector T: Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis 70: 349-355, 2011

3. Goto T, Shinoda Y, Okuma T, Ogura K, Tsuda Y, Yamakawa K, Hozumi T: Administration of nonsteroidal anti-inflammatory drugs accelerates spontaneous healing of osteoid osteoma. Arch Orthop Trauma Surg 131: 619-625, 2011

4. Muraki S, Akune T, Oka H, En-yo Y, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N: Health-related quality of life with vertebral fracture, lumbar spondylosis and knee osteoarthritis in Japanese men: the ROAD study. Arch Osteoporosis 5: 91-99, 2011

5. Clark JC, Akiyama T, Thomas DM, Labrinidis A, Evdokiou A, Galloway SJ, Kim HS, Dass CR, Choong PF: RECK in osteosarcoma: A novel role in tumour vasculature and inhibition of tumorigenesis in an orthotopic model. Cancer 117: 3517-3528, 2011

6. Kyomoto M, Moro T, Takatori Y, Kawaguchi H, Ishihara K: Cartilage-mimicking, high-density brush structure improves wear resistance of crosslinked polyethylene: a pilot study. Clin Orthop Relat Res 469: 2327-2336, 2011

7. Kyomoto M, Moro T, Takatori Y, Kawaguchi H, Nakamura K, Ishihara K: Cartilage-mimicking, high-density brush structure improves wear resistance of cross-linked polyethylene: A pilot study. Clin Orthop Relat Res 469: 2327-2336, 2011

8. Matsudaira K , Hara N , Arisaka M , Isomura T: Comparison of physician’s advice for non-specific acute low back pain in Japanese workers: advice to rest versus advice to stay active. Ind Health 49: 203-208, 2011

9. Ogata N, Shinoda Y, Wettschureck N, Offerman S, Takeda S, Nakamura K, Segre GV, Chung UI, Kawaguchi H: The Gαq signal in osteoblasts is inhibitory to the osteoanabolic action of PTH. J Biol Chem 286: 13733-13740, 2011

10. Ishiyama N, Moro T, Ohe T, Miura T, Ishihara K, Konno T, Ohyama T, Yoshikawa M, Kyomoto M, Saito T, Nakamura K, Kawaguchi H: Reduction of peritendinous adhesions by hydrogel containing biocompatible phospholipid polymer MPC for tendon repair. J Bone Joint Surg Am 93: 142-149, 2011

11. Motosuneya T, Maruyama T, Yamada H, Tsuzuki N, Sakai H: Long-term results of tension-band laminoplasty for cervical stenotic myelopathy. A ten-year follow-up. J Bone Joint Surg Br 93: 68-72, 2011

12. Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T: Capacity of endogenous sex steroids to predict bone loss in Japanese men: 10-year follow-up of the Taiji Cohort Study. J Bone Miner Metab 29: 96-102, 2011

13. Kamitani-Kawamoto A, Hamada M, Moriguchi T, Miyai M, Saji F, Hatamura I, Nishikawa K, Takayanagi H, Hitoshi S, Ikenaka K, Hosoya T, Hotta Y, Takahashi S, Kataoka K: MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development. J Bone Miner Res Epub, 2011

14. Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S: Epigenetic Regulation of Osteoclast Differentiation: Possible Involvement of Jmjd3 in the Histone Demethylation of Nfatc1. J Bone Miner Res Epub ahead of print, 2011

15. Yasui T, Kadono Y, Nakamura M, Oshima Y, Matsumoto T, Masuda H, Hirose J, Omata Y, Yasuda H, Imumara T, Nakamura K, Tanaka S: Regulation of RANKL-induced osteoclastogenesis by TGF-Β through molecular interaction between Smad3 and Traf6. J Bone Miner Res 26: 1447-1456, 2011

16. Kanetaka M, Sugita S, Chikuda H, Takeshita K, Ono T, Oshima Y, Kawaguchi H, Nakamura K: Use of Doppler ultrasonography to detect an elusive communication of a spinal extradural arachnoid cyst. J Clin Neurosci 18: 863-864, 2011

17. Goto T, Shinoda Y, Tsuda Y, Yamakawa K, Hozumi T: Pyomyositis with minimal inflammation mimicking soft tissue tumour in patients with diabetes mellitus: report of two cases. J Jpn College Surgeons 36: 107-112, 2011

18. Taketomi S, Hiraoka H, Nakagawa T, Miyamoto Y, Kuribayashi S, Fukuda A, Takeda H, Fukai A, Hirota J, Nakajima K, Haga N, Nakamura K: Osteochondral autograft for medial femoral condyle chondral lesions in a patient with multiple epiphyseal dysplasia: long-term result. J Orthop Sci Epub ahead of print, 2011

19. Morii J, Takeshita K, Chikuda H, Hara N, Oshima Y, Seichi A, Kawaguchi H, Nakamura K: Long-term Outcomes of Cervical Laminoplasty　–A Comparison of JOACMEQ and Other Outcomes–. Journal of Spine Research 2: 287-290, 2011

20. Goto T, Nemoto T, Ogura K, Imanishi J, Hozumi T, Funata N: Eosinophilic granuloma of the capital femoral epiphysis. J Pediatr Orthop B 20: 157-161, 2011

21. Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T: Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women: the ROAD study. J Rheumatol 38: 921-930, 2011

22. Sakai H, Hiraoka H, Yashiki M: Gravity-assisted pivot-shift test can predict the function of the reconstructed anterior cruciate ligament. Knee Surg Sports Traumatol Arthrosc 19: 572-578, 2011

23. Taketomi S, Nakagawa T, Takeda H, Nakajima K, Nakayama S, Fukai A, Hirota J, Kachi Y, Kawano H, Miura T, Fukui N, Nakamura K: Anatomical placement of double femoral tunnels in anterior cruciate ligament reconstruction: anteromedial tunnel first or posterolateral tunnel first? Knee Surg Sports Traumatol Arthrosc 19: 424-431, 2011

24. Momohara S, Tanaka S, Nakamura H, Mibe J, Iwamoto T, Ikari K, Nishino J, Kadono Y, Yasui T, Takahashi K, Takenouchi K, Hashizume K, Nakahara R, Kubota A, Nakamura T, Nishida K, Suguro T: Recent trends in orthopedic surgery performed in Japan for rheumatoid arthritis. Mod Rheumatol 21: 337-342, 2011

25. Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M: Hes1 functions downstream of growth factors to maintain oligodendeocyte lineage cells in the early progenitor stage. Neuroscience 176: 132-141, 2011

26. Matsudaira K, Palmer KT, Reading I, Hirai M, Yoshimura N, Coggon D: Prevalence and correlates of regional pain and associated deniability in Japanese workers. Occup Environ Med 68: 191-196, 2011

27. Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB: Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: The TREAT-OA Consortium. Osteoarthr Cartilage 19: 254-264, 2011

28. Muraki S, Oka H, Akune T, En-yo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N: Association of occupational activity with joint space narrowing and osteophytosis in the medial compartment of the knee: The ROAD study. Osteoarthr Cartilage 19: 840-846, 2011

29. Ueno T, Ohori Y, Ito J, Hoshikawa S, Yamamoto S, Nakamura K, Tanaka S, Akai M, Tobimatsu Y, Ogata T: Hyperphosphorylated neurofilament NF-H as a biomarker of the efficacy of minocycline therapy for spinal cord injury. Spinal Cord 49: 333-336, 2011

30. Muraki S, Akune T, Oka H, Enyo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N: Health-related quality of life in subjects with low back pain and knee pain in a population-based cohort study of Japanese men: the ROAD study. Spine 36: 1312-1319, 2011

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