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Supplementary MaterialCASE REPORT: Segmental arterial mediolysis (SAM) leading to chronic renal insufficiency.John-Paul O’Shea,1 Sarah Gordon,2 Richard Horak,3 and J. Matthew Meadows31Department of Medicine, Tripler Army Medical Center, 1 Jarret White Road, DHCK-DM, Honolulu, HI 96859, USA.2Department of Nephrology, Walter Reed National Military Medical Center, 4494 North Palmer Road, Bethesda, MD 20889, USA3Department of Radiology, Tripler Army Medical Center, 1 Jarret White Road, Honolulu, HI 96859, USA.Corresponding author: John-Paul O’Shea; john-paul.oshea.civ@mail.mil Table S1. Summary of combining SAM progression and deaths due to SAM, differentiated by treatment groupTreatment groupTotal Number in Treatment GroupCombined (Deceased due to SAM + Progression)Combined as a% of treatment groupConservative (Medical) Management371437.8Open Surgical Management8977.9Endovascular Management (Stent, ballooning, embolization)2627.7Observation only191789.5subtotal1714023.4Table S2. Summary of Non-systematic Literature Review of Outcomes of SAM, differentiated by treatment group.Treatment groupTreatment group totalsStable or no progression of SAMDeceased due to SAM complicationDeceased due to unrelated complicationProgression of SAM or consequent disease(includes new aneurysms, dissections, CKD etc after initial 1 month)Not reportedConservative (Medical) Management37206182Open Surgical Management89787004Endovascular Management (Stent, ballooning, embolization)26240020Observation only19017200subtotal171122303106total171Table S3. Summary of combining SAM progression and deaths due to SAM, differentiated by treatment groupLEGENDInterventions:OutcomesComorbiditiesC = conservative/medicalS = stable/no progressionAF = atrial fibrillationO = open surgicalDS = deceased due to SAMCHF = congestive heart failureEV = endvascular stenting/embolization/angioplastyDN = deceased unrelated to SAMhld = hyperlipidemiaN = none/observation onlyP = progression beyond 1 month of initial presentation (new aneurysm, dissection, disease manifestation)htn = HypertensionN = not reportedsm = smokingYearComorbidityVesselsInterventionComplications/ ProgressionOriginal Reference if referred to in a source referenceSource Reference2019?bilateral renal aaCP*Current case report2019scleroderma, raynaudgastric epiploic aa aneurCP*(1)2018AF, htn, CHF, MV repairgastroduodenal, splenic, both renal aa aneurysms, celiac axis, hemoperioteumPS(2)2018?R/L bilateral renal aaCN(3)2017Ob, AF, VTE, CKD, herniaSup mesenteric aaCS(4)2017mucosal gastric cancerbilateral renal aaOS(5)2016sminitial right renal aa, then 3 wk splenic and sup mesentericCDS(6)2016nonesma dissectionEVP(7)2016htn, hld, AFsma dissectionCP(7)2016hldceliac axis dissectionCS(7)2016htn, AF, chfpha, rha, lha. lga, aneuysms, R renal aa steonosisEVS(7)2016nonesma dissectionEVP(7)2016nonesma dissection, R colic aa dissection, mi colic artery occlusionCP(7)YearComorbidityVesselsInterventionComplications/ ProgressionOriginal Reference if referred to in a source referenceSource Reference2016noneceliac axis stenosis, cha stenosis, splenic aa occlusionCS(7)2016noneGDA pseudoaneurysm, Celiac axis dissectionEVS(7)2016?Lt. colic a.OSGalketiya K, Llewellyn H, Liang X. 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Interact Cardiovasc Thorac Surg. 2015; 21(6):814–6. doi: 10.1093/icvts/ivv249 PMID: 26362627.(7)2015?SMAEVSLiao CY, Kuo WH, Huang EH, Hsieh AT, Le CC, Tsai CC, et al. A diagnostic dilemma: acute abdomen presenting as segmental arterial mediolysis masked by a ruptured hepatocellular carcinoma. Gastroen- terol Rep (Oxf). 2015. doi: 10.1093/gastro/gov030 PMID: 26163669.(7)2015?Renal a.EVSRuderman I, Menahem S. Segmental arterial mediolysis mimicking medium-vessel vasculitis. Nephrol- ogy (Carlton). 2015; 20(3):224–5. doi: 10.1111/nep.12360 PMID: 25712556.(7)2014?Middle colic a.OSNishimura K, Hamasaki T, Ota R, Ohno T, Kodama W, Uchida N, et al. Elective treatment of middle colic artery aneurysm. Ann Vasc Dis. 2014; 7(3):328–30. doi: 10.3400/avd.cr.14-00058 PMID: 25298839; PubMed Central PMCID: PMC4180699.(7)YearComorbidityVesselsInterventionComplications/ ProgressionOriginal Reference if referred to in a source referenceSource Reference2014?SMA, IMA, ileocolic a. 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