Duke University



Learning Objectives WEEK 11 RESPIRATORY SYSTEMVocabularyacute interstitial pneumonia (AIP)adult respiratory distress syndrome (ARDS)allergic bronchopulmonary aspergillosis (ABPA) alveolar-capillary membraneanthracosisasbestosasbestosisasteroid bodyasthmaatelectasisbagassosisbarrel chestbird-fancier's diseaseblebblue bloaterbranchial cleft cystbronchial cystbronchiectasisbronchiolitis obliteransbronchogenic carcinomabronchogenic cystbronchopulmonary sequestrationbullabyssinosisCaplan syndromeCharcot-Leyden crystalchronic bronchitischronic obstructive pulmonary disease (COPD)coin lesionconsolidationcor pulmonaleCurschmann spiraldiffuse alveolar damage (DAD)dyspneaemphysemaempyemafarmer's lungferruginous bodyGhon complex Goodpasture syndromeHamman-Rich syndromeheart failure cellhemoptysishemothoraxhistiocytosis Xhoneycomb lungHorner syndromehyaline membranehypersensitivity pneumonitis (HP)hypertrophic pulmonary osteoarthropathyidiopathic interstitial pneumonia (IIP)idiopathic pulmonary fibrosis (IPF)juvenile laryngeal papillomatosislymphangiitic carcinomatosisMeigs syndromenasopharyngeal carcinomanon-small cell lung cancer (NSCLC)obstructive lung diseaseorganizing pneumoniaPancoast tumorparaneoplastic syndromepigeon-breeder's lungpink pufferplexiform lesionpneumoconiosis pneumothoraxpulmonary edemapulmonary embolismpulmonary veno-occlusive disease (PVOD)ralesReid indexrestrictive lung diseaserhonchisaddle embolusscar carcinomaSchaumann bodysevere acute respiratory syndrome (SARS)silicatosissilicosissilo-filler's diseasesingers’ nodesmall airways diseasestatus asthmaticustension pneumothoraxtumorletvocal cord noduleDescribe the mechanisms by which the following pulmonary defense mechanisms accomplish their functions:nasal clearancelaryngeal (including epiglottic) actiontracheobronchial clearancealveolar clearanceExplain the pathogenesis of each of the manifestations of pulmonary disease:paincoughdyspneasputum productioncyanosisclubbing of fingers hypertrophic pulmonary osteoarthropathysecondary polycythemiahemptysiscor pulmonaleDiscuss the following pulmonary congenital anomalies, in terms of morphology and clinical consequences:agenesishypoplasiacongenital lobar overinflation ("emphysema")congenital cystbronchopulmonary sequestrationContrast obstructive and restrictive pulmonary disease, in terms of:morphologic featuresradiologic manifestationspulmonary function test resultsclinical manifestationsCompare and contrast the etiologies and effects of airflow obstruction that occur in lesions involving the airways with those that involve the alveolar pare and contrast the clinical and pathologic features of:emphysemachronic bronchitisbronchial asthmabronchiectasisCompare and contrast the clinical and pathologic features of bronchial asthma:atopicnon-atopicdrug-inducedoccupationalCompare and contrast the clinical and pathologic features ofcentriacinar (centrolobular) emphysema panacinar (panlobular) emphysemaparaseptal (distal acinar) emphysemafocal emphysemainterstitial emphysemasenile "emphysema"congenital lobar "emphysema"Discuss the Reid indexDiscuss respiratory bronchiolitis of smokers (small airways disease) in terms of: pathogenesismorphology clinical presentationDiscuss bronchiectasis, in terms of:predisposing conditionsthe types of organisms typically cultured from bronchisequelaeCompare and contrast neonatal and adult respiratory distress syndrome in terms of:predisposing factors/associated conditionspathogenesismorphologycomplicationsclinical courseCompare and contrast the clinical and pathologic features of the following lung diseases:diffuse alveolar damage (DAD)bronchilitis obliterans-organizing pneumonia (BOOP)usual interstitial pneumonia (UIP)desquamative interstitial pneumonia (DIP)lymphoid interstitial pneumonia (LIP)nonspecific interstitial pneumonia (NSIP)Discuss the clinical and pathologic features of the following disorders:sarcoidosisGoodpasture syndromeidiopathic pulmonary hemosiderosis (IPH)hypersensitivity pneumonitis (HP)pulmonary alveolar proteinosispulmonary eosinophilic granulomapulmonary infiltrates with eosinophilia (PIE)lipid pneumoniaWegener granulomatosis lymphomatoid granulomatosisDiscuss pulmonary invovement in autoimmune ("collagen-vascular") diseases, noting the major morphologic manifestations in the lung of:systemic lupus erythematosus (SLE)rheumatoid arthritis (RA)progessive systemic sclerosis (PSS)Discuss the basic pathogenesis of pare and contrast the clinical and pathologic features of the following pneumoconioses:coal workers' pneumoconioses silicosisasbestosisberylliosisDiscuss the clinical and pathologic features of these asbestos-related lung diseases:fibrous pleural plaquespleural effusionasbestosisbronchogenic carcinomamalignant mesotheliomaDiscuss the acute and chronic stages of radiation lung injury, in terms of:temporal featurespathogenesismorphologyconsequencesDiscuss drug-induced lung disease, enumerating drugs most commonly associated with the following pulmonary reactions:bronchospasmpulmonary edemahypersensitivity pneumonitis (HP)eosinophilic pneumoniadiffuse alveolar damage (DAD)pulmonary fibrosisEnumerate the general indications for lung transplantation, and complications pulmonary infectionacute rejectionchronic rejectionDiscuss the pulmonary features of cystic fibrosis (CF), in terms of:frequency of involvement of lung in CFpathogenesismorphologyfunctional alterationsclinical manifestationspulmonary complicationsobstructiveinfectious (including most common organisms involved)treatmentprognosisCompare and contrast the clinical and pathologic features of:bronchopneumonialobar pneumoniaprimary atypical pneumoniaaspiration pneumonialung abscesspulmonary infiltrates in the immunocompromised hostDescribe the four classic stages of the inflammatory response in lobar pneumoniatemporal featuresmorphologyDiscuss the clinical and pathologic features of respiratory tract infections:????????? anthrax????????? crytococossis????????? Legionnaire's disease????????? aspergillosis????????? actinomycosis????????? mucormycosis????????? nocardiosis????????? respiratory syncytial virus (RSV) ????????? tuberculosis????????? influenza pneumonia????????? atypical mycobacteriosis ????????? adenovirus pneumonia????????? mycoplasma pneumonia????????? cytomegalic virus (CMV)????????? psittacosis????????? acute respiratory syndrome ????????? histoplasmosis????????? Pneumocystis carinii pneumonia (PCP)????????? coccidioidomycosis????????? toxoplasmosis????????? blastomycosis????????? strongyloides26. Differentiate among tuberculosis, sarcoidosis, and granulomatous fungal disease etiopathogenesismorphologic features, including use of special stainsorgans involvedradiologic featuresclinical presentationdiagnostic testslaboratory findingsprognosis27. Discuss pulmonary edema, embolism, and infarction in terms of:predisposing factors and etiologypathogenesismorphologic featuresradiologic featuresclinical manifestations28. Compare and contrast the clinical and pathologic features of pulmonary embolism: thrombusfatair bone marrowamniotic fluid talc29. Compare and contrast primary and secondary pulmonary hypertension, in terms of:predisposing factors/associated conditionspathogenesisage and sex distributionclinical manifestationssize and type of vessels involvedmorphologic features (including reversible vs. irreversible lesions)hemodynamic consequences prognosis30. Discuss the clinical and pathologic features of:pulmonary circulatory disease associated with congenital heart diseasepersistent fetal circulation31. Compare and contrast the clinical and pathologic features of the following thoracic tumors:squamous cell carcinoma of lungbronchogeneic adenocarcinomabronchioloalveolar carcinomasmall cell carcinoma of lunglarge cell carcinoma of lungbronchial carcinoidpulmonary hamartomamalignant lymphomaHodgkin diseasemetastatic neoplasm to thoraxpleural fibroma (solitary fibrous tumor)malignant mesothelioma32. List likely etiologies and expected effects on pulmonary function of: hydrothoraxempyemahemothoraxchylothoraxpneumothoraxtension pneumothoraxpleural adhesion33. Discuss pleural fluid collections on the basis of fluid type and common associations34. List appropriate diagnostic procedures for patients with pleural effusions35. Compare and contrast the clinical and pathologic features of:nasal polypsinonasal papillomalaryngeal nodule (singers' node)laryngeal papilloma juvenile laryngeal papillomatosis laryngeal squamous cell carcinoma nasopharyngeal carcinoma ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download