FRACP Questions 1997- HAEMATOLOGY
FRACP Questions- HAEMATOLOGY
2000 PAPER
Question 1
A 70 year old woman presents with borderline cervical lymphadenopathy. Investigations reveal;
WCC- 11, Hb 105, Plts N
The blood film reveals atypical lymphocytes, smear cell
What is the next best investigation?
A) Bone marrow biopsy
B) EBV serology
C) Immunophepnotyping of peripheral cells
D) Cytogenetics on peripheral blood
E) No further IX required
Question 2
A 67 year old man presents with confusion, nausea and vomiting and fevers.
Investigation is as follows:
Urea – 30, Creat 0.29, Hb – 75, Plts 40, retics 125, mcv 101, wcc 10
LDH – 1000, Bili – 80, DIC screen normal (?fib), coombs neg
Blood film shows fragmented RBC
What is the must likely diagnosis?
A) Gram negative sepsis
B) Evans
C) TTP
D) DIC
F) ALL
G) Cold agglutinins
Question 3
A 25 year old woman presents with easy bruising, petechiae and gum bleeds. Examination reveals
No organomegaly.
Investigations: Hb – 110, WCC – N, Plts 14, ANA – 1:40, HIV negative
Bone marrow – increased megakaryocytes
What is the best treatment?
A) Splenectomy
B) Prednisilone
C) Plasmaphoresis
D) Platelet transfusion
E) IVIG
Question 4
A young woman has a DVT without any provoking risk factor. What is the most likely mechanism?
A) Protein C deficiency
B) Protein S deficiency
C) Factor V Leiden
D) Antiphospholipid antibodies
E) Antithrombin III deficiency
Question 5
A young woman is developing a non febrile transfusion reaction after her recurrent blood transfusions.
What is the reason to use filter?
A) Decrease donor white cells
B) Decrease bacterial contamination
C) Decrease donor cytokines
D) Decrease CMV transmission
E) Decrease ABO antigens
Question 6
A 70 year old woman presents with a 4 week history of increasing tiredness and lethargy and on examination is found to be mildly ichteric. (previous B12 deficiency now adequate Rx)
Investigations reveal a Hb – 75, MCV – 125, WCC 2.1 with PMN – 1.3, Plts – 90, retics 4
Blood film is shown – macrocytes, hypersegmented neutrophils and target cells.
LFTs – mildly elevated bilirubin, otherwise normal.
What is the most likely diagnosis?
A) Pernicious anaemia
B) PNH
C) Aplastic anaemia
D) Hypothyroidism
E) Evans syndrome
F) Alcohol
Question 7
A couple have presented for genetic counselling as both come from families with a history of thalassaemia. Which of the following combinations has the best prognosis?
Partner A Partner B
A) alpha 0 alpha 0
B) alpha 0 alpha 1
C) HbE Beta
D) alpha 0 Beta
E) Beta Beta
Question 8
A 75 year old man presents for elective cholecystectomy and is found to have a WCC of 85, with normal Hb and Plts. He is assymptomatic and on examination has no lymphadenopathy, nor splenomegaly.
(Cells CD19 and CD23 positive)
What is the best treatment?
A) Chlorambucil
B) Chlorambucil and prednisilone
C) Observe
D) Prednisilone alone
E) Allogeneic BMT
Question 9
A 32 year old man has CML.
Which of the following treatments gives the best chance of longterm survival?
A) Interferon
B) Interferon and ara-C
C) Hydroxyurea
D) Allogeneic BMT
E) Autologous BMT
Question 10
A 60 year old man presents with a fractured neck of femur. He has a Past history of IHD and is an exsmoker. On examination he has a plethoric appearance.
Investigations: Hb – 219, Hct – 69%, WCC – 15, Plts – 215.
He requires surgery within 2 days. (post op) (EPO level won’t be available in time)
What is the most appropriate immediate Rx?
A) Hydroxyurea
B) Venesection
C) Anticoagulation
D) Radioactive phosphorus
E) Chlorambucil
F) Observe
Question 11
Which of the following is least likely to be a factor in the risk for GVHD?
A) ABO incompatibility
B) In vitro T cell deplation of the graft
C) HLA mismatch
D) Age of the patient
E) Sibling vs unrelated transplant
Question 12
Which cells in the bone marrow is the most actively dividing?
A) Pluripotent stem cells
B) Myeloblasts
C) Metamyelocytes
D) Monomyelocytes
E) Granulocyte reserve
Question 13
A 60 year old woman with a history of fever, malaise and cervical lymphadenoapthy of 2 weeks duration. 2 Paul Bunnel tests a week apart were negative. Blood tests show WCC raise with lymphocytes raised. Which of the following is the most likely diagnosis?
A) EBV infection (absent in one version)
B) CMV
C) Toxoplasmosis
D) Strep pharyngitis
E) HIV
Question 14
A young female with haemolysis, C3 ++++, increased MCV, increased LDH. The most likely finding on blood smear is:
A) Target cells
B) Spherocytes
C) Rouleaux formation
D) RBC (cold) agglutination
E) Hypersegmented neutrophils
F) RBC fragments
Question 15
Which of the following is least likely to be toxic to bone marrow?
A) Carboplatin
B) Etoposide
C) Cyclophosphamide
D) Doxorubicin
E) Vincristine
Question 16
A patient comes for elective surgery – assymptomatic and blood count shows a mildly elevated WBC of WCC – 16 with a high percentage of lymphocytes. The blood filme is given with increased lympocytes and 1 smear cell.
What test would you do for the diagnosis?
A) Bone marrow biopsy
B) Cytogenetics
C) Immunophenotyping
FRACP 1999
Question 1
Interferon has proven to be the most beneficial in affecting the mortality of which of the following?
A) Myeloma
B) CML
C) CLL
D) Myelofibrosis
Question 2
The most consistent finding for alpha thalassaemia is which of the following lab results?
A) Reduced MCV
B) Anaemia
C) Gene deletion
D) HbH
Question 3
Which of the following is most responsible compenent for the pathogenesis of beta thalassaemia?
A) Iron overload
B) Haemolytic anaemia
C) Alpha beta chain imbalance
D) Beta chain dysfunction
Question 4
A patient bleeds while receiving low molecular weight heparin for a deep vein thrombosis. Which of the following tests will best determine if the LMWH is the cause?
A) Anti factor Xa assay
B) Thrombin time
C) Prothrombin time
D) Bleeding time
E) TF VII assay
Question 5
Blood product infections (viral infection in one version) are most likely to occur with :
A) RBCs
B) FFP
C) Factor VIII concentrate
D) Anti D
E) Platelets
Question 6
A 28 week pregenant presents with SOB. On examination is noted to be dyspnoeic and the ABG demonstrates hypoxia. A doppler shows a DVT in the common femoral vein. A VQ scan is offered but will not be available for 2 dayds. The best treatment for this lady is?
A) Thrombolysis
B) Intravenous heparin followed by S/C heaprin
C) Intravenous heaprin followed by PO warfarin
D) IVC filter
FRACP 1998
Question 1
Anaemia associated with which of the following is best responsive to EPO?
A) Myelofibrosis
B) Sideroblastic anaemia
C) CRF
D) Chemotherapy induced
E) Chronic inflammatory state
FRACP 1997
PAPER 1
Question 6
Which of the following regimens is most likely to prevent further thrombus extension or embolism when standard heparin treatment is complicated by the heparin induced thrombocytopenia/thrombosis syndrome?
A. Warfarin plus dextran
B. Warfarin plus aspirin
C. A low molecular weight heparanoid (orgaran)
D. A low molecular weight heparin (eg. enoxaparin)
E. Aspirin plus dextran
Question 37
Which of the following is the most common finding in alpha thalassaemia carrier state trait?
A. Increased haemoglobin F concentration
B. Point mutations
C. Mild microcytic anaemia
D. Haemoglobin H inclusion bodies
E. Gene deletion
Question 50
A man presents with extensive lymphoma.
Investigations reveal :
Hb: 100g/L (125-165)
MCV 74 fL (81-97)
Serum Fe 4 umol/L (13-36)
Serum Ferritin 300 ug/L (20-25)
Which one of the following gives the best explanation of the RBC microcytosis and hypochromia in this man?
A. Rapid clearance of circulating iron from plasma
B. Impaired release of iron from macrophages
C. Reduced erythropoeitin secretion
D. Iron defeciency
E. Reticulocytosis
Question 63
Which of the following is the most likely to account for recurrent venous thrombosis in an otherwise healthy male aged 30 who presents without an obvious predisposing cause but a positive family history of thrombosis?
A. Antithrombin III deficiency
B. Resistance to activated protein C
C. Protein S deficiency
D. Abnormality in fibrinogen
E. Protein C deficiency
PAPER 2
Question 2
Which of the following is the most consistently found in a carrier with thalassaemia?
A. DNA deletion involving the globin gene
B. HbH inclusions in the peripheral blood
C. HbF- containing cells in the peripheral blood
D. Raised HbA2 level
E. Microcytic hypochromic red blood cells
Question 18
A 20 year old woman presents with weight loss, agitation and a palpable thyroid. The following results are obtained:
TSH ................
................
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