THE SCIENCE EXCHANGE



What is type 2 diabetes?

Type 2 diabetes is a lifelong disease that affects the way your body uses food for energy. The disease develops when an organ called the pancreas cannot make enough insulin or when the body is not able to use insulin correctly. Insulin is a hormone that allows the body's cells to use sugar (glucose) for energy. Insulin also helps the body store extra sugar in muscle, fat, and liver cells.

When insulin is not available or is not used correctly, the level of sugar in your blood gets too high and cells do not get the energy they need. If your blood sugar stays high for a long time, you can develop problems with your eyes, heart, blood vessels, nerves, and kidneys.

Controlling your blood sugar is the best way to avoid serious complications from type 2 diabetes, such as heart and blood vessel diseases. Many people who have type 2 diabetes enjoy healthy, active lives when they are able to control their blood sugar. Exercising, eating healthy foods, and taking medicines all help control blood sugar.

More and more adults and children are developing type 2 diabetes. This is largely because of bad eating habits and a lack of physical activity. It is important to know whether you or your children are at risk for type 2 diabetes and to know what you can do to help prevent the disease.

What causes type 2 diabetes?

You can develop type 2 diabetes if:

• Your body does not respond as it should to insulin, making it hard for your cells to get glucose from the blood for energy. This is called insulin resistance.

• Your pancreas does not make enough insulin.

Your weight, how much physical activity you get, and your family history all affect the way your body responds to insulin. If you are overweight, get little or no exercise, or have family members with diabetes, you have a greater chance of developing type 2 diabetes.

What are the symptoms?

At first, your blood sugar level may rise so slowly that you may not know that anything is wrong. One-third of all people who have diabetes do not know that they have the disease. 1

If you do have symptoms of type 2 diabetes, they may include:

• Feeling thirsty.

• Having to urinate more than usual.

• Feeling more hungry than usual.

• Losing weight without trying to.

• Feeling tired.

• Feeling cranky.

You may find out that you have type 2 diabetes during a regular medical checkup or during an appointment for another health problem such as high blood pressure, an infection, or a wound that heals slowly. Some people do not find out they have diabetes until they have a complication from the disease, such as vision problems, kidney disease, nerve disease, or heart and blood vessel problems.

How is type 2 diabetes diagnosed?

If your doctor thinks that you have type 2 diabetes, he or she will ask you questions about your medical history, do a physical exam, and order a blood glucose test. A blood glucose test is a blood test that measures the amount of sugar in your blood. The test is usually done first thing in the morning, before you eat or drink anything.

How is it treated?

Treatment for type 2 diabetes includes eating more foods that are good for you, getting regular exercise, checking your blood sugar levels, and possibly taking medicines. You will also visit your doctor regularly to make sure your treatment is working and that you are not having more serious health problems.

Can type 2 diabetes be prevented?

If you are at risk for type 2 diabetes or if you have a condition called prediabetes—when your blood sugar levels are above normal but not high enough for a diagnosis of diabetes—you may be able to prevent or delay the disease by exercising regularly and changing the way you eat. Often, people who develop type 2 diabetes are overweight and not physically active. By losing as few as 10 or 20 pounds, you can reduce your chances of developing diabetes.

What is type 1 diabetes?

Type 1 diabetes is a lifelong disease that develops when the pancreas stops producing insulin. Insulin lets blood sugar—also called glucose—enter your body's cells, where it is used for energy. Without insulin, the amount of sugar in the blood rises above a safe level, and the cells do not get the sugar they need. Over time, high blood sugar can damage blood vessels and nerves throughout your body and increase your risk of eye, heart, blood vessel, nerve, and kidney diseases. If your blood sugar level becomes very high, a life-threatening chemical imbalance (diabetic ketoacidosis) can develop.

Type 1 diabetes can develop at any age; however, it usually develops in children and young adults, which is why it used to be called juvenile diabetes. It has also been called insulin-dependent diabetes mellitus (IDDM) because insulin injections must be taken daily. One kind of type 1 diabetes—latent autoimmune diabetes of adulthood, or LADA—develops in adulthood. It sometimes is confused with type 2 diabetes because it starts later than most cases of type 1.

About 5% to 10% of all people with diabetes have type 1. 1 Type 2 diabetes is the most common type of diabetes; other forms of the disease include gestational and secondary diabetes.

What causes type 1 diabetes?

Insulin normally is made by beta cells in a portion of the pancreas called the islet tissue. For unknown reasons, type 1 diabetes develops because the body destroys the beta cells. This is called an autoimmune disease. (LADA develops in adulthood because it takes a long time for the body to destroy all the insulin-producing cells.)

Some people inherit a tendency for type 1 diabetes. People who have a parent, brother, or sister with type 1 diabetes are more likely than other people to develop the disease; however, most people with type 1 diabetes do not have a family history of it. Even with a family history of diabetes, you might not develop the disease unless you are exposed to something in the environment that triggers it. Experts debate whether enteroviral infections, especially Coxsackie B, and not being breast-fed beyond 3 months of age may increase the risk for type 1 diabetes.

Other factors that increase your risk are being white and having islet cell antibodies in your blood.

What are the symptoms?

Symptoms of diabetes are increased thirst, increased urination, weight loss, and sometimes increased appetite. These symptoms usually develop over a few days to weeks. Occasionally, some people notice symptoms after an illness, such as the flu. They may think the diabetes symptoms are related to the flu and not seek medical care early.

Sometimes, a person may develop symptoms of diabetic ketoacidosis before seeking medical care. Symptoms include:

• Flushed, hot, dry skin.

• Loss of appetite, abdominal pain, and vomiting.

• A strong, fruity breath odor (similar to nail polish remover or acetone).

• Fast and shallow breathing.

• Restlessness, drowsiness, difficulty waking up, confusion, or coma.

How is it diagnosed?

A health professional diagnoses diabetes using a medical history, physical examination, and blood tests to measure glucose. The diagnosis needs to be confirmed by a blood glucose test done on another day. Some people are diagnosed with type 1 diabetes because they have diabetic ketoacidosis.

How is it treated?

Treatment for type 1 diabetes focuses on keeping blood sugar levels within a target range. Treatment requires:

• Taking daily insulin injections.

• Eating a healthy diet that spreads carbohydrate throughout the day.

• Monitoring blood sugar levels at home.

• Getting regular exercise.

Treatment may be adjusted based on the results of daily home blood sugar tests and other tests and examinations.

In some situations, a person may have a pancreas transplant, which allows his or her body to produce insulin. A pancreas transplant may be done at the same time a person has a kidney transplant. Surgery to insert pancreas cells (islet cell transplant) is an experimental treatment that is being done in some research centers. Both surgeries are expensive. Afterward, the person must take immunosuppressant medication for the rest of his or her life to prevent rejection of the new tissue.

People with type 1 diabetes can live long, healthy lives if they keep their blood sugar levels as close to normal as possible. When a small child has diabetes, the parents assume the responsibility for blood sugar control; as the child grows, he or she can assume more responsibility for diabetes care.

Can I prevent type 1 diabetes?

Currently there is no way to prevent type 1 diabetes. However, studies are being done to look at ways of preventing or delaying the onset of diabetes in people who are most likely to develop the disease.

Tight control of blood sugar and blood pressure can help people with type 1 diabetes prevent or delay the development of complications, such as damage to the eyes, kidneys, heart, blood vessels, and nerves.

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