Infections and autoimmunity as risk factors for mental ...
[Pages:33]Common threads New York March 2018
Infections and autoimmunity as risk factors for mental disorders
- Danish nationwide register and biobank studies
Michael Eriksen Benr?s
M.D., Ph.D.
The Danish Registers
Prescription Database All redeemed
prescriptions since 1995 CPR-number Register
Hospital Registers - Psychiatry since
1969 - Somatic since 1977
Michael Eriksen Benr?s
Benros@dadlnet.dk
SCHIZOPHRENIA OR RELATED PSYCHOSIS (F20-29)
Autoimmune diseases and infections as risk factors for schizophrenia (1977-2006)
(N=3,56 million; Schizophrenia cases=39,076)
Benros et al. 2011, American Journal of Psychiatry
Michael Eriksen Benr?s
Benros@dadlnet.dk
SCHIZOPHRENIA OR RELATED PSYCHOSIS (F20-29)
Autoimmune diseases and infections as risk factors for schizophrenia (1977-2006)
(N=3,56 million; Schizophrenia cases=39,076)
Benros et al. 2011, American Journal of Psychiatry
Michael Eriksen Benr?s
Benros@dadlnet.dk
SCHIZOPHRENIA OR RELATED PSYCHOSIS (F20-29)
Autoimmune diseases and schizophrenia risk
Michael Eriksen Benr?s
Benros@dadlnet.dk
SCHIZOPHRENIA OR RELATED PSYCHOSIS (F20-29)
Localization of the infection and schizophrenia risk
Michael Eriksen Benr?s
Benros@dadlnet.dk
SCHIZOPHRENIA (F20)
Risk of schizophrenia (F20) and association with type of first infection
(N=843,390 born 1981-2000, Schizophrenia cases=3,409)
Type of infection
IRR 95% CI Cases
Bacterial infection only 1.73 1.55-1.92
415
Viral infection only
1.40 1.25-1.56
382
Different types No infections
1.48 1.36-1.61
752
1.00 (reference) 1,860
Nielsen PR, Benros ME, Mortensen PB. Schizophr Bull. 2014
Michael Eriksen Benr?s
Benros@dadlnet.dk
DEPRESSION (F30-39)
Autoimmune diseases and infections as risk factor for mood disorders
(1977-2010; N=3,56 millioner; F30-F39=91,637)
Benros et al. JAMA Psychiatry. 2013
Michael Eriksen Benr?s
Benros@dadlnet.dk
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