Infections and autoimmunity as risk factors for mental ...

[Pages:33]Common threads New York March 2018

Infections and autoimmunity as risk factors for mental disorders

- Danish nationwide register and biobank studies

Michael Eriksen Benr?s

M.D., Ph.D.

The Danish Registers

Prescription Database All redeemed

prescriptions since 1995 CPR-number Register

Hospital Registers - Psychiatry since

1969 - Somatic since 1977

Michael Eriksen Benr?s

Benros@dadlnet.dk

SCHIZOPHRENIA OR RELATED PSYCHOSIS (F20-29)

Autoimmune diseases and infections as risk factors for schizophrenia (1977-2006)

(N=3,56 million; Schizophrenia cases=39,076)

Benros et al. 2011, American Journal of Psychiatry

Michael Eriksen Benr?s

Benros@dadlnet.dk

SCHIZOPHRENIA OR RELATED PSYCHOSIS (F20-29)

Autoimmune diseases and infections as risk factors for schizophrenia (1977-2006)

(N=3,56 million; Schizophrenia cases=39,076)

Benros et al. 2011, American Journal of Psychiatry

Michael Eriksen Benr?s

Benros@dadlnet.dk

SCHIZOPHRENIA OR RELATED PSYCHOSIS (F20-29)

Autoimmune diseases and schizophrenia risk

Michael Eriksen Benr?s

Benros@dadlnet.dk

SCHIZOPHRENIA OR RELATED PSYCHOSIS (F20-29)

Localization of the infection and schizophrenia risk

Michael Eriksen Benr?s

Benros@dadlnet.dk

SCHIZOPHRENIA (F20)

Risk of schizophrenia (F20) and association with type of first infection

(N=843,390 born 1981-2000, Schizophrenia cases=3,409)

Type of infection

IRR 95% CI Cases

Bacterial infection only 1.73 1.55-1.92

415

Viral infection only

1.40 1.25-1.56

382

Different types No infections

1.48 1.36-1.61

752

1.00 (reference) 1,860

Nielsen PR, Benros ME, Mortensen PB. Schizophr Bull. 2014

Michael Eriksen Benr?s

Benros@dadlnet.dk

DEPRESSION (F30-39)

Autoimmune diseases and infections as risk factor for mood disorders

(1977-2010; N=3,56 millioner; F30-F39=91,637)

Benros et al. JAMA Psychiatry. 2013

Michael Eriksen Benr?s

Benros@dadlnet.dk

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