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2738494-250900Presenter:Rawan Bassam Itani Date:21July,2020Instructor: Prof. SamihTamimiTime: 4 pmLocation:online zoom meetingSevere vitamin D deficiency as a biomarker for autoimmune hepatitisAbstractResearch shows a strong correlation between vitamin D deficiency and autoimmune diseases, Low vitamin D in the body is linked to a higher risk for developing chronic illnesses, both systemic disease and organ-specific ( AIH ), vitamin D deficiency reflects the severity of the liver disease or constitutes a predisposition for advanced liver disease that is discovered at presentation, severe vitamin D deficiency in the study suggests that the serum vitamin D level was a marker of severe liver disease rather than a major pathogenic factor, AIH patients have low of vitamin D levels, AIH responds favorably to immunosuppressive treatment, which should be started as soon as thediagnosis is made, the objectives were to correlate vitamin D deficiency with treatment response, progression to cirrhosis and liver‐related mortality, and the current definitions of treatment response and progression to cirrhosis include the laboratory, histological studies that been applied.References 1-Ebadi M, Bhanji RA, Mazurak VC, et al. Severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis. Aliment PharmacolTher. 2019; 49:173– 182.2-Czaja AJ. Epigenetic changes and their implications in autoimmune hepatitis. Eur J Clin Invest. 2018;48: e12899. 3-Wang J, Xu J, Shao X, et al. Letter: vitamin D deficiency and autoimmune hepatitis – from research to treatment. Aliment PharmacolTher. 2019; 49:1103. ................
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