PCB 4233C Immunology
Weekly Schedule of Activities
|Date |Session Topics |Readings & Assignments |
|Week 1 |Course Overview |Chapter 1 |
|Aug 23 -25 |Elements of the Immune System |Lab Safety and Review of Techniques |
| |Historical Perspective |Quiz: Immunology Terminology |
| |Innate vs Adoptive Immunity |Blood Smear and identification of lymphoid |
| |Lymphoid System |cells |
| |Overview of Antibody and Cell Mediated Immunity | |
|Define immunity and resistance to disease. |
|Describe the branches of the immune system. |
|Distinguish between a primary and secondary immune response. |
|Compare and contrast innate and acquired immunity. |
|Identify the molecular properties of antigens and their contribution to immune recognition. |
|Define hapten, antigen and epitope. |
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|Date |Session Topics |Readings & Assignments |
|Week 2 |Antibody Structure and Generation of B-cell Diversity |Chapter 2 |
|Aug 30 – |Basic Structure of Immunoglobulins | |
|Sept 1 |Immunoglobulin Sequencing Studies |Immunodiffusion Techniques, Precipitation |
| |Immunoglobulin Fine Structure |Reactions, Ouchterlony Tests and Forensic |
| |B-Cell Receptor |Serology |
| |Antigenic determinants on Immunoglobulins | |
| |Immunoglobulin Classes | |
| |Monoclonal Antibodies | |
| |Immunoglobulin Genetics | |
|Discuss how the structure of immunoglobulins contribute to both their specificity and their effector functions. |
|Explain the basic structure of an antibody molecule. |
|List the five immunoglobulin classes and their biological function |
|Describe organization of Ig genes |
|Describe class switching |
|Define how antibody structure contributes to antibody specificity and effector function |
|Describe how the binding strength of an antibody-antigen is determined. |
|Date |Session Topics |Readings & Assignments |
|Week 3 |Antigen Recognition by T lymphocytes |Ch 3 |
|Sept 6 -8 |T Cell diversity |Isolation and enumeration of Lymphocytes |
| |Ag processing and MHC antigens | |
| |MHC gene organization and distribution |Quiz: Evaluate immunodiffusion results |
| |Regulation of MHC genes | |
| |MHC genes and Immunoresponsiveness | |
|List the different types of T cells and their function |
|Describe the TCR complex |
|Describe how T cells recognize antigen |
|Distinguish between MHC class I and class II |
|Describe the function of MHC receptors |
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|Date |Session Topics |Readings & Assignments |
|Week 4 |EXAM 1 |Ch 1-3 |
|Sept. 13-15 |Lymphocyte markers |Presentation topic and resources due |
| | |Flow cytometer |
|List the receptors used to identify B & Tcells |
|Describe the use of a flow cytometer in the identification of lymphoid cells |
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|Date |Session Topics |Readings & Assignments |
|Week 5 |B cell Development |Ch 4 |
|Sept. 20-22 |Maturation and abnormalities |Lymphocyte stimulation |
|Describe the Development of B cells |
|Discuss the progression of Ig gene rearrangement with B cells |
|Discuss abnormalities in malignant B cells in relation to B cell development |
|Date | Session Topics |Readings & Assignments |
|Week 6 |Development of T cells |Ch 5 & 6 |
|Sept. 27-29 |Thymus education |Agglutination reactions |
| |Positive and negative selection |(Blood typing) |
| |T cell maturation | |
| |T cell malignancies | |
|List the cell surface receptors used to identify T and B cells |
|List type of T cells |
|Describe difference between T cell type and function |
|Describe lymphocyte matuation in tissues |
|List types of T cell malignancies and correlate with normal T cell development |
| Date |Session Topics |Readings & Assignments |
|Week 7 |T cell mediated immunity |Presentations draft due |
|Oct. 4-6 |T cell trafficking |ELISA |
| |T cell signaling | |
|List the properties of the significant cytokines |
|Describe potential therapeutic uses of cytokines |
|Discuss mechanism involved in T cell cytotoxicity |
|Describe assays to measure T cell function |
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|Date |Session Topics |Readings & Assignments |
|Week 8 |EXAM 2 (trade day for Nov 22) |Ch 1-6 |
|Oct 11-13 |Immunity mediated by B cells and Complement system |CH 50 Assay |
|Understand procedures for measuring complement activity |
|Correlate complement levels and activity with clinical syndromes |
|Date |Session Topics |Readings & Assignments |
|Week 9 |B cell mediated Immunity |Ch 7 |
|Oct. 18-20 | |Bactericidal Assay |
| |Ab. Production | |
| |T ind. and dept antigens | |
| |Complement | |
| |Components, Activation, Regulation, Deficiencies | |
|Compare T and T independent antigens |
|Compare and contrast the classical and alternate complement systems |
|Discuss consequences of Complement activation and deficiences |
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|Date |Session Topics |Readings & Assignments |
|Week 10 |Body/s Defense against infections |Ch 8 |
|Oct. 25 -27 |Innate Immunity |Phagocytosis |
| |Epithelium | |
| |Phagocytosis and NK activity | |
| |Adaptive Immunity | |
| |TH1 and TH 2 | |
| |Immunological memory | |
|List various components of innate and adaptive immune response |
|Describe pathways involved in inflammation |
|Define immunological memory |
|Describe differences between primary and secondary response |
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|Date |Session Topics |Readings & Assignments |
|Week 11 |EXAM 3 |Ch 9 |
|Nov 1 –3 |Failure of Body’s Defenses |Alpha 2 mac |
| |Evasion of the immune system by pathogens | |
| |Inherited and Acquired Immunodeficiencies | |
|List possible mechanisms organisms use to evade host defense mechanisms |
|Discuss role of inheritance associated with specific immunodeficiencies |
|List external factors that contribute to immunodeficiencies |
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|Date |Session Topics |Readings & Assignments |
|Week 12 |Overreaction of Immune system |Ch 11 |
|Nov 8- 10 |Hypersensitivity Reactions |ANA Assay |
| |Disruption of Healthy tissue by Immune response | |
| |Autoimmune disease | |
|Discuss the mechanisms and consequences of the four primary types of hypersensitive reactions. |
|Describe the principal mediators involved in the four primary types of hypersensitivities. |
|Discuss the timing of the reaction in the types of hypersensitivity reactions. |
|Describe the different mechanism involved in T and B tolerance and the role of antigen in each |
|Discuss possible mechanism involved in the development of autoimmune disease |
|Describe differences between systemic and organ specific autoimmunity |
|List specific autoimmune diseases and their immunological origin |
|List detection mechanisms for identifying and treating autoimmune diseases |
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|Date |Session Topics |Readings & Assignments |
|Week 13 |Autoimmune Disease continued |Ch 12 |
|Nov. 15 - 17 |Manipulation of the Immune system |Alpha 2 mac |
| |Vaccination | |
| |Transplantation | |
| |Immunosuppression | |
| |Tumor immunogenicity | |
| |Immunological techniques | |
|This session will address the following learning objectives: |
|Compare various methods of vaccination listing strengths and weaknesses of each |
|Discuss immunological basis of organ transplantation |
|List mechanisms/ treatments to prevent graft rejection |
|Discuss the concept of immunological surveillance and tumor development |
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|Date |Session Topics |Readings & Assignments |
|Week 14 |Free day (traded for Oct 11) | |
|Nov 22 -24 | | |
| |Thanksgiving | |
|Experience the impact of over satiation and relaxation on comprehension skills |
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|Date |Session Topics |Readings & Assignments |
|Week 15 |Oral Presentations and Reveiw | |
|Nov 29- Dec 1 | | |
|Application of immunology principles to specific topics selected by students |
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|Date |Session Topics |Readings & Assignments |
|Week 16 | EXAM 4 Cumulative Final |Ch 1-12 and presentations |
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