A Tale of two dogs: Meningoencephalitis of unknown ...
A TALE OF TWO DOGS: MENINGOENCEPHALITIS OF
UNKNOWN ETIOLOGY (MUE)
Sarah Trub, DVM (Resident in Neurology & Neurosurgery)
Meningoencephalitis
? Inflammation of the brain and leptomeninges ? Meningoencephalomyelitis if spinal cord is also
involved
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Two groups of etiologies
? Infectious ? Immune-mediated
Common infectious etiologies
? Protozoal ? Toxoplasma ? Neospora
? Viral ? Distemper
? Rickettsial diseases ? E. canis ? Anaplasma spp ? R. rickettsii (RMSF)
? Fungal ? Cryptococcus spp ? Coccidioides immitis
? Bacterial
4
Meningoencephalitis of Unknown Etiology
? Encompasses all clinically diagnosed cases of noninfectious inflammatory CNS disease
? Does not include diseases without overt CNS involvement (i.e. SRMA)
? Histopathology is necessary for definitive diagnosis of subtype
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