A Tale of two dogs: Meningoencephalitis of unknown ...

A TALE OF TWO DOGS: MENINGOENCEPHALITIS OF

UNKNOWN ETIOLOGY (MUE)

Sarah Trub, DVM (Resident in Neurology & Neurosurgery)

Meningoencephalitis

? Inflammation of the brain and leptomeninges ? Meningoencephalomyelitis if spinal cord is also

involved

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Two groups of etiologies

? Infectious ? Immune-mediated

Common infectious etiologies

? Protozoal ? Toxoplasma ? Neospora

? Viral ? Distemper

? Rickettsial diseases ? E. canis ? Anaplasma spp ? R. rickettsii (RMSF)

? Fungal ? Cryptococcus spp ? Coccidioides immitis

? Bacterial

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Meningoencephalitis of Unknown Etiology

? Encompasses all clinically diagnosed cases of noninfectious inflammatory CNS disease

? Does not include diseases without overt CNS involvement (i.e. SRMA)

? Histopathology is necessary for definitive diagnosis of subtype

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