Pain Drug Comparison Chart
Pain Drug Comparison Chart
Painkillers are among the most commonly used drugs
in the United States. Deciding which to use deserves
careful consideration. Use this quick comparison chart to
help guide a conversation with your doctor about which
medications are best and safest for you.
COMMON SENSE
CONSIDERATIONS
? Talk with your doctor about medication dosage and
possible contraindications.
? Never take any drugs when you are pregnant without
first consulting your doctor.
? Exercise caution with sensitive groups such as children,
the elderly and those with serious health conditions.
OVER THE COUNTER
Generic Name
Best Used For
Information provided by
Sutter Health¡¯s MyLifeStages
and pain management specialist
Karen Pantazis, M.D.
Classification
Brand Name
Aspirin
Aspirin
Family
Bayer
Bufferin
Ascriptin
Ecotrin
St. Joseph¡¯s
Minor aches and pains, fever
reduction and
anti-inflammatory
? GI bleeding
? Increased bleeding
? Ulcers
? May contribute to
macular degeneration
? Risk of Reyes syndrome in children
and teens
? Do not combine with blood thinner
medication
? Can cause tinnitus in high doses
? Can cause kidney
problems
Tylenol
Excedrin
Acetaminophen
Pain and fever
reduction
? Itching/swelling
(especially of the face/
tongue/throat)
? Rash
? Dizziness
? Bloody stools
? Stomach bleeding
? Liver damage possible if you take
more than recommended dose or you
drink alcohol.
? OTC cough and flu products contain
acetaminophen. It can add up quickly.
Limit total dose per day to 2000 mg.
Advil
Motrin
Aleve
Ibuprofen, naproxen
¨C also known as non
steroidal
Pain, fever reduction and
anti-inflammatory
?
?
?
?
?
? May increase risk of
cardiac events and stroke
? Increases risk of GI bleeding and
perforation
? Can cause kidney
problems
Acetaminophen
NSAIDs
Common Side Effects
Heartburn
Nausea
Rash
Dizziness
Stomach pain
Warnings
OVER THE COUNTER [con¡¯t]
Classification
Brand Name
Generic Name
Best Used For
Midol Preps
Combinations of
acetaminophen,
caffeine, naproxen,
aspirin
For headaches,
bloating, fatigue and
menstrual symptoms
?
?
?
?
?
Vanquish
Combination
of aspirin,
acetominophen and
caffeine
For headaches,
migraines, headaches,
muscle aches,
menstrual aches, or
other minor aches and
pains due to sinusitis,
arthritis, or colds
? Irritation of stomach or
intestines
? Nervousness
? Nausea
? Taste problems
? Trouble sleeping
? Ulcer from stomach acid
Excedrin
Migraine
Combinations of
acetaminophen,
caffeine and
ibuprofen
Migraine pain
?
?
?
?
?
Combination
Drugs
Painkillers
combining one
or more classes
of OTC drugs.
Common Side Effects
Dizziness
GI bleeding
GI upset
Irritability
Nervousness
Warnings
? Consider all warnings for aspirin, acetaminophen and NSAIDs like ibuprofen,
since combination drugs may combine
one or more classes.
Dizziness
GI bleeding
GI upset
Irritability
Nervousness
PRESCRIPTION
Classification
Opioid
Analgesics
Brand Name
Generic Name
Best Used For
Common Side Effects
Warnings
Vicodin
Norco
Lortab / Lorcet
Hydrocodone and
acetaminophen
Moderate to
Severe Pain
? Constipation, nausea, respiratory
depression in high doses or when
mixed with other meds or alcohol,
can lead to death
? Do not overtake these medications!
Take ONLY as prescribed.
Oxycodone
Percocet
Oxycodone
Oxycodone and
acetaminophen
Morphine
Methadone
Hydromorphone
Oxymorphone
Fentanyl Patch
MS ER / Kadian
Methadone
Dilaudid
Opana
Duragesic Patch
Neuropathic Pain Medication
NonOpioid
Analgesics
Gabapentin
Tramadol
Pregabalin
Duloxetine
Topiramate
Nortriptylline
Neurontin
Ultram
Lyrica
Cymbalta
Topamax
Pamelor
Opioid Agonist / Antagonists
Butrans
Bupronorphene Patch
Severe Pain
? Can lead to death from respiratory
depression if overtaken or mixed with
other sedatives, including alcohol.
? Can lead to dependence and tolerance,
which are different than addiction.
? Can lead to addiction, especially in high
risk individuals
Moderate to
Severe Pain
? Dizziness
? Nausea
? Do not stop medication suddenly
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