TITLE: Early Mortality in Hyperleukocytosis in Patients ...
Galactomannan, Beta-D-Glucan and PCR-Based Assays for the Diagnosis of Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-AnalysisThomas Lehrnbecher MD1, Paula D Robinson MD, MSc2, Brian T. Fisher DO, MSCE3, Elio Castagnola MD4, Andreas H. Groll MD5, William J. Steinbach MD6, Theoklis E. Zaoutis MD, MSCE 3, Zelalem F Negeri MSc7, Joseph Beyene PhD7,8, Bob Phillips MD9 and Lillian Sung MD, PhD101Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe University, Frankfurt, Germany; 2Pediatric Oncology Group of Ontario, Toronto, Canada; 3Division of Pediatric Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; 4Infectious Diseases Unit, Istituto Giannina Gaslini, Genova, Italy; 5Infectious Disease Research Program, Center for Bone Marrow Transplantation, Department of Pediatric Hematology/Oncology, University Children’s Hospital Muenster, Albert Schweitzer Campus 1, Building A1, 48149 Muenster, Germany; 6Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA; 7Department of Mathematics & Statistics and 8Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada; 9Leeds General Infirmary, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom and Centre for Reviews and Dissemination, University of York, York, UK; 10Division of Haematology/Oncology, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, CanadaKey Words: Invasive fungal disease; Pediatric; Galactomannan, Beta-D-glucan; Polymerase-Chain ReactionRunning Title: Fungal Biomarkers in Pediatric Cancer Key points: Galactomannan, beta-D-glucan, and polymerase-chain-reaction-based assays to detect invasive fungal disease in pediatric cancer or hematopoietic stem-cell transplantation patients demonstrated high negative predictive values for galactomannan, but overall, variable and generally poor sensitivity, specificity and positive predictive values for all biomarkers.Address for CorrespondenceThomas Lehrnbecher, MD Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents Johann Wolfgang Goethe-University Theodor-Stern-Kai 7D-60590 Frankfurt, GermanyPhone/Fax: +49 69 6301 83481 / +49 69 6301 6700E-mail: Thomas.Lehrnbecher@kgu.deWord Count: Abstract 136; Text 3000; Tables 5; Figures 1; Supplemental Files 2ABSTRACTWe systematically reviewed and analyzed the available data for galactomannan (GM), beta-D-glucan (BG), and polymerase-chain reaction (PCR)-based assays to detect invasive fungal disease (IFD) in pediatric cancer or hematopoietic stem cell transplantation (HSCT) patients when used as screening tools during immunosuppression or as diagnostic tests in patients presenting with symptoms such as fever during neutropenia (FN). Out of 1,532 studies screened, 25 studies reported on GM (n=19), BG (n=3) and PCR (n=11). All fungal biomarkers demonstrated highly variable sensitivity, specificity and positive predictive values, and these were generally poor in both clinical settings. GM negative predictive values were high, ranging from 85-100% for screening and 70-100% in the diagnostic setting, but failure to identify non-Aspergillus molds limits its usefulness. Future work could focus on the usefulness of combinations of fungal biomarkers in pediatric cancer and HSCT. BACKGROUNDInvasive fungal disease (IFD) is an important contributor to morbidity and mortality in pediatric patients who receive intensive chemotherapy or who undergo allogeneic hematopoietic stem cell transplantation (HSCT) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc3RvbjwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc3RvbjwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+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ADDIN EN.CITE.DATA [1-3]. One important strategy which may improve outcome is the early detection of IFD through the use of biomarkers, including galactomannan (GM), beta-D-glucan (BG), and polymerase-chain reaction (PCR)-based assays ADDIN EN.CITE <EndNote><Cite><Author>Ambasta</Author><Year>2015</Year><RecNum>9815</RecNum><DisplayText>[4]</DisplayText><record><rec-number>9815</rec-number><foreign-keys><key app="EN" db-id="pzfzsxppfv29xheprrspv9fova255v520aws" timestamp="1458477957">9815</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ambasta, A.</author><author>Carson, J.</author><author>Church, D. L.</author></authors></contributors><auth-address>Medicine, University of Calgary, Calgary, Alta.
Division of Microbiology, University of Calgary, Calgary, Alta Calgary Laboratory Services, and the Departments of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alta.
Division of Microbiology, University of Calgary, Calgary, Alta Calgary Laboratory Services, and the Departments of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alta Medicine, University of Calgary, Calgary, Alta deirdre.church@cls.ab.ca.</auth-address><titles><title>The use of biomarkers and molecular methods for the earlier diagnosis of invasive aspergillosis in immunocompromised patients</title><secondary-title>Med Mycol</secondary-title><alt-title>Medical mycology</alt-title></titles><periodical><full-title>Med Mycol</full-title><abbr-1>Medical mycology</abbr-1></periodical><alt-periodical><full-title>Med Mycol</full-title><abbr-1>Medical mycology</abbr-1></alt-periodical><pages>531-57</pages><volume>53</volume><number>6</number><dates><year>2015</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1460-2709 (Electronic)
1369-3786 (Linking)</isbn><accession-num>26026174</accession-num><urls><related-urls><url>;[4]. These assays can be performed in specimens such as blood, broncho-alveolar lavage (BAL) fluid, cerebrospinal fluid (CSF) or in tissue biopsies. Assays may be used either as a screening tool during high-risk periods, for example, in asymptomatic patients with neutropenia or graft-versus-host disease (GVHD), or as a diagnostic tool in symptomatic patients, for example, in patients with prolonged fever and neutropenia (FN) or in patients in whom IFD is suspected. We hypothesized that the setting of testing (screening versus diagnostic test) would alter the utility of the test through changing the pre-test probability of the infection.In adult patients, GM, BG and PCR-based assays are accepted tools to support the diagnosis of IFD, but to date, only GM and BG are incorporated into the criteria of defining opportunistic IFD and invasive aspergillosis (IA) set forth by the European Organisation for Research and Treatment of Cancer/Mycosis Study Group (EORTC/MSG) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBQYXV3PC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBQYXV3PC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE.DATA [5]. Importantly, the utility of these tests in children has been questioned PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9sbDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9sbDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
Y051bT44ODU1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls2LThdPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjg4NTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i
IGRiLWlkPSJwemZ6c3hwcGZ2Mjl4aGVwcnJzcHY5Zm92YTI1NXY1MjBhd3MiIHRpbWVzdGFtcD0i
MTQyOTUzMzU1NiI+ODg1NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy
bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+
R3JvbGwsIEEuIEguPC9hdXRob3I+PGF1dGhvcj5DYXN0YWdub2xhLCBFLjwvYXV0aG9yPjxhdXRo
b3I+Q2VzYXJvLCBTLjwvYXV0aG9yPjxhdXRob3I+RGFsbGUsIEouIEguPC9hdXRob3I+PGF1dGhv
cj5FbmdlbGhhcmQsIEQuPC9hdXRob3I+PGF1dGhvcj5Ib3BlLCBXLjwvYXV0aG9yPjxhdXRob3I+
Um9pbGlkZXMsIEUuPC9hdXRob3I+PGF1dGhvcj5TdHljenluc2tpLCBKLjwvYXV0aG9yPjxhdXRo
b3I+V2FycmlzLCBBLjwvYXV0aG9yPjxhdXRob3I+TGVocm5iZWNoZXIsIFQuPC9hdXRob3I+PGF1
dGhvcj5Gb3VydGggRXVyb3BlYW4gQ29uZmVyZW5jZSBvbiBJbmZlY3Rpb25zIGluLCBMZXVrYWVt
aWE8L2F1dGhvcj48YXV0aG9yPkluZmVjdGlvdXMgRGlzZWFzZXMgV29ya2luZyBQYXJ0eSBvZiB0
aGUgRXVyb3BlYW4gR3JvdXAgZm9yIEJsb29kIE1hcnJvdywgVHJhbnNwbGFudGF0aW9uPC9hdXRo
b3I+PGF1dGhvcj5JbmZlY3Rpb3VzIERpc2Vhc2VzIEdyb3VwIG9mIHRoZSBFdXJvcGVhbiBPcmdh
bmlzYXRpb24gZm9yLCBSZXNlYXJjaDwvYXV0aG9yPjxhdXRob3I+VHJlYXRtZW50IG9mLCBDYW5j
ZXI8L2F1dGhvcj48YXV0aG9yPkludGVybmF0aW9uYWwgSW1tdW5vY29tcHJvbWlzZWQgSG9zdCwg
U29jaWV0eTwvYXV0aG9yPjxhdXRob3I+RXVyb3BlYW4gTGV1a2FlbWlhLCBOZXQ8L2F1dGhvcj48
L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbmZlY3Rpb3VzIERpc2Vhc2Ug
UmVzZWFyY2ggUHJvZ3JhbSwgQ2VudGVyIGZvciBCb25lIE1hcnJvdyBUcmFuc3BsYW50YXRpb24g
YW5kIERlcGFydG1lbnQgb2YgUGVkaWF0cmljIEhlbWF0b2xvZ3kvT25jb2xvZ3ksIFVuaXZlcnNp
dHkgQ2hpbGRyZW4mYXBvcztzIEhvc3BpdGFsLCBNdW5zdGVyLCBHZXJtYW55LiBFbGVjdHJvbmlj
IGFkZHJlc3M6IGdyb2xsYW5AdWttdWVuc3Rlci5kZS4mI3hEO0luZmVjdGlvdXMgRGlzZWFzZXMg
VW5pdCwgRGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNzLCBJc3RpdHV0byAmcXVvdDtHaWFubmluYSBH
YXNsaW5pJnF1b3Q7LCBHZW5vdmEsIEl0YWx5LiYjeEQ7UGVkaWF0cmljIEhlbWF0b2xvZ3kgT25j
b2xvZ3ksIEF6aWVuZGEgT3NwZWRhbGllcmEgVW5pdmVyc2l0YXJpYSBJbnRlZ3JhdGEsIFZlcm9u
YSwgSXRhbHkuJiN4RDtIZW1hdG8tSW1tdW5vbG9neSBEZXBhcnRtZW50LCBSb2JlcnQgRGVicmUg
SG9zcGl0YWwsIFVuaXZlcnNpdGUgUGFyaXMgNywgUGFyaXMtRGlkZXJvdCwgRnJhbmNlLiYjeEQ7
RGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNzLCBIYWRhc3NhaC1IZWJyZXcgVW5pdmVyc2l0eSBNZWRp
Y2FsIENlbnRlciwgSmVydXNhbGVtLCBJc3JhZWwuJiN4RDtBbnRpbWljcm9iaWFsIFBoYXJtYWNv
ZHluYW1pY3MgYW5kIFRoZXJhcGV1dGljcywgRGVwYXJ0bWVudCBvZiBNb2xlY3VsYXIgYW5kIENs
aW5pY2FsIFBoYXJtYWNvbG9neSwgVW5pdmVyc2l0eSBvZiBMaXZlcnBvb2wsIExpdmVycG9vbCwg
VUsuJiN4RDtJbmZlY3Rpb3VzIERpc2Vhc2VzIFVuaXQsIDNyZCBEZXBhcnRtZW50IG9mIFBlZGlh
dHJpY3MsIEZhY3VsdHkgb2YgTWVkaWNpbmUsIEFyaXN0b3RsZSBVbml2ZXJzaXR5IFNjaG9vbCBv
ZiBIZWFsdGggU2NpZW5jZXMgYW5kIEhpcHBva3JhdGlvbiBIb3NwaXRhbCwgVGhlc3NhbG9uaWtp
LCBHcmVlY2UuJiN4RDtEZXBhcnRtZW50IG9mIFBlZGlhdHJpYyBIZW1hdG9sb2d5IGFuZCBPbmNv
bG9neSwgQ29sbGVnaXVtIE1lZGljdW0sIE5pY29sYXVzIENvcGVybmljdXMgVW5pdmVyc2l0eSwg
QnlkZ29zemN6LCBQb2xhbmQuJiN4RDtBYmVyZGVlbiBGdW5nYWwgR3JvdXAsIFVuaXZlcnNpdHkg
b2YgQWJlcmRlZW4sIEluc3RpdHV0ZSBvZiBNZWRpY2FsIFNjaWVuY2VzLCBBYmVyZGVlbiwgU2Nv
dGxhbmQsIFVLLiYjeEQ7UGVkaWF0cmljIEhlbWF0b2xvZ3kgYW5kIE9uY29sb2d5LCBDaGlsZHJl
biZhcG9zO3MgSG9zcGl0YWwsIEpvaGFubiBXb2xmZ2FuZyBHb2V0aGUtVW5pdmVyc2l0eSwgRnJh
bmtmdXJ0LCBHZXJtYW55LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkZvdXJ0aCBFdXJv
cGVhbiBDb25mZXJlbmNlIG9uIEluZmVjdGlvbnMgaW4gTGV1a2FlbWlhIChFQ0lMLTQpOiBndWlk
ZWxpbmVzIGZvciBkaWFnbm9zaXMsIHByZXZlbnRpb24sIGFuZCB0cmVhdG1lbnQgb2YgaW52YXNp
dmUgZnVuZ2FsIGRpc2Vhc2VzIGluIHBhZWRpYXRyaWMgcGF0aWVudHMgd2l0aCBjYW5jZXIgb3Ig
YWxsb2dlbmVpYyBoYWVtb3BvaWV0aWMgc3RlbS1jZWxsIHRyYW5zcGxhbnRhdGlvbjwvdGl0bGU+
PHNlY29uZGFyeS10aXRsZT5MYW5jZXQgT25jb2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl
PlRoZSBMYW5jZXQuIE9uY29sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1
bGwtdGl0bGU+TGFuY2V0IE9uY29sPC9mdWxsLXRpdGxlPjxhYmJyLTE+VGhlIGxhbmNldCBvbmNv
bG9neTwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTMyNy00MDwvcGFnZXM+PHZvbHVtZT4x
NTwvdm9sdW1lPjxudW1iZXI+ODwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50
PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzLyp0aGVyYXBldXRpYyB1c2U8L2tl
eXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwv
a2V5d29yZD48a2V5d29yZD5IZW1hdG9wb2lldGljIFN0ZW0gQ2VsbCBUcmFuc3BsYW50YXRpb24v
KmFkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv
cmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPkxldWtlbWlhLypjb21wbGljYXRpb25zPC9rZXl3
b3JkPjxrZXl3b3JkPk15Y29zZXMvKmRpYWdub3Npcy8qZHJ1ZyB0aGVyYXB5L2VwaWRlbWlvbG9n
eS9ldGlvbG9neS9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+T3Bw
b3J0dW5pc3RpYyBJbmZlY3Rpb25zLypkaWFnbm9zaXMvKmRydWc8L2tleXdvcmQ+PGtleXdvcmQ+
dGhlcmFweS9lcGlkZW1pb2xvZ3kvZXRpb2xvZ3kvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9r
ZXl3b3JkPjxrZXl3b3JkPlRyYW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291czwva2V5d29yZD48L2tl
eXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRl
PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQ3NC01NDg4IChFbGVjdHJvbmljKSYjeEQ7MTQ3
MC0yMDQ1IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNDk4ODkzNjwvYWNjZXNzaW9u
LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292
L3B1Ym1lZC8yNDk4ODkzNjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+MTAuMTAxNi9TMTQ3MC0yMDQ1KDE0KTcwMDE3LTg8L2VsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkJ1Y2hoZWlkdDwvQXV0aG9y
PjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT40MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+
NDE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJlZXJ3c3hw
d2R6emFybmV4dDBqeHcwMDZlejBhYTAwNXcyNXMiIHRpbWVzdGFtcD0iMCI+NDE8L2tleT48L2Zv
cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+
PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJ1Y2hoZWlkdCwgRC48L2F1dGhvcj48YXV0
aG9yPlJlaW53YWxkLCBNLjwvYXV0aG9yPjxhdXRob3I+U3BpZXNzLCBCLjwvYXV0aG9yPjxhdXRo
b3I+Qm9jaCwgVC48L2F1dGhvcj48YXV0aG9yPkhvZm1hbm4sIFcuIEsuPC9hdXRob3I+PGF1dGhv
cj5Hcm9sbCwgQS4gSC48L2F1dGhvcj48YXV0aG9yPkxlaHJuYmVjaGVyLCBULjwvYXV0aG9yPjxh
dXRob3I+V29ya2luZyBHcm91cCAmcXVvdDtJbmZlY3Rpb25zIGluLCBIZW1hdG9sb2d5PC9hdXRo
b3I+PGF1dGhvcj5PbmNvbG9neSwgR2VybWFuIFBhdWwtRWhybGljaC1Tb2NpZXR5PC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1h
dG9sb2d5IGFuZCBPbmNvbG9neSwgTWFubmhlaW0gVW5pdmVyc2l0eSBIb3NwaXRhbCwgVW5pdmVy
c2l0eSBvZiBIZWlkZWxiZXJnLCBNYW5uaGVpbSwgR2VybWFueS4mI3hEO0luZmVjdGlvdXMgRGlz
ZWFzZSBSZXNlYXJjaCBQcm9ncmFtLCBDZW50ZXIgZm9yIEJvbmUgTWFycm93IFRyYW5zcGxhbnRh
dGlvbiBhbmQgRGVwYXJ0bWVudCBvZiBQZWRpYXRyaWMgSGVtYXRvbG9neSBhbmQgT25jb2xvZ3ks
IFVuaXZlcnNpdHkgQ2hpbGRyZW4mYXBvcztzIEhvc3BpdGFsLCBNdW5zdGVyLCBHZXJtYW55LiYj
eEQ7RGl2aXNpb24gb2YgUGVkaWF0cmljIEhlbWF0b2xvZ3kgYW5kIE9uY29sb2d5LCBIb3NwaXRh
bCBmb3IgQ2hpbGRyZW4gYW5kIEFkb2xlc2NlbnRzLCBKb2hhbm4gV29sZmdhbmcgR29ldGhlLVVu
aXZlcnNpdHksIEZyYW5rZnVydCwgR2VybWFueS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs
ZT5CaW9tYXJrZXItYmFzZWQgZGlhZ25vc3RpYyB3b3JrLXVwIG9mIGludmFzaXZlIHB1bG1vbmFy
eSBhc3BlcmdpbGxvc2lzIGluIGltbXVub2NvbXByb21pc2VkIHBhZWRpYXRyaWMgcGF0aWVudHMt
LWlzIEFzcGVyZ2lsbHVzIFBDUiBhcHByb3ByaWF0ZT88L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+
TXljb3Nlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TXljb3NlczwvYWx0LXRpdGxlPjwv
dGl0bGVzPjxwYWdlcz42Ny03NDwvcGFnZXM+PHZvbHVtZT41OTwvdm9sdW1lPjxudW1iZXI+Mjwv
bnVtYmVyPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViPC9kYXRl
PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQzOS0wNTA3IChFbGVjdHJvbmljKSYjeEQ7MDkz
My03NDA3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNjc1NjU3MTwvYWNjZXNzaW9u
LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292
L3B1Ym1lZC8yNjc1NjU3MTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+MTAuMTExMS9teWMuMTI0NDM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv
cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhlcmJyZWNodDwvQXV0aG9yPjxZZWFyPjIwMDI8
L1llYXI+PFJlY051bT41ODUyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41ODUyPC9yZWMt
bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0icHpmenN4cHBmdjI5eGhl
cHJyc3B2OWZvdmEyNTV2NTIwYXdzIiB0aW1lc3RhbXA9IjAiPjU4NTI8L2tleT48L2ZvcmVpZ24t
a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy
aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhlcmJyZWNodCwgUi48L2F1dGhvcj48YXV0aG9yPkxl
dHNjaGVyLUJydSwgVi48L2F1dGhvcj48YXV0aG9yPk9wcmVhLCBDLjwvYXV0aG9yPjxhdXRob3I+
TGlvdXJlLCBCLjwvYXV0aG9yPjxhdXRob3I+V2FsbGVyLCBKLjwvYXV0aG9yPjxhdXRob3I+Q2Ft
cG9zLCBGLjwvYXV0aG9yPjxhdXRob3I+VmlsbGFyZCwgTy48L2F1dGhvcj48YXV0aG9yPkxpdSwg
Sy4gTC48L2F1dGhvcj48YXV0aG9yPk5hdGFyYWphbi1BbWUsIFMuPC9hdXRob3I+PGF1dGhvcj5M
dXR6LCBQLjwvYXV0aG9yPjxhdXRob3I+RHVmb3VyLCBQLjwvYXV0aG9yPjxhdXRob3I+QmVyZ2Vy
YXQsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5DYW5kb2xmaSwgRS48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRlbWVudCBkJmFwb3M7SGVtYXRvbG9n
aWUgZXQgZCZhcG9zO09uY29sb2dpZSwgSG9waXRhdXggVW5pdmVyc2l0YWlyZXMgZGUgU3RyYXNi
b3VyZywgRnJhbmNlLiByYW91bC5oZXJicmVjaHRAY2hydS1zdHJhc2JvdXJnLmZyPC9hdXRoLWFk
ZHJlc3M+PHRpdGxlcz48dGl0bGU+QXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBkZXRlY3Rpb24g
aW4gdGhlIGRpYWdub3NpcyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIGNhbmNlciBwYXRp
ZW50czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIENsaW4gT25jb2w8L3NlY29uZGFyeS10aXRs
ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIENsaW4gT25jb2w8L2Z1bGwtdGl0
bGU+PGFiYnItMT5Kb3VybmFsIG9mIGNsaW5pY2FsIG9uY29sb2d5IDogb2ZmaWNpYWwgam91cm5h
bCBvZiB0aGUgQW1lcmljYW4gU29jaWV0eSBvZiBDbGluaWNhbCBPbmNvbG9neTwvYWJici0xPjwv
cGVyaW9kaWNhbD48cGFnZXM+MTg5OC05MDY8L3BhZ2VzPjx2b2x1bWU+MjA8L3ZvbHVtZT48bnVt
YmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5
d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQs
IDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlib2RpZXMsIEZ1bmdhbC9pc29sYXRp
b24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKmRp
YWdub3Npcy8qbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzL2Vuenlt
b2xvZ3kvaW1tdW5vbG9neS8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48
a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3Jk
PjxrZXl3b3JkPkRpYWdub3NpcywgRGlmZmVyZW50aWFsPC9rZXl3b3JkPjxrZXl3b3JkPkVuenlt
ZS1MaW5rZWQgSW1tdW5vc29yYmVudCBBc3NheTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tl
eXdvcmQ+PGtleXdvcmQ+RmV2ZXIvKmV0aW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5
d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPk1h
bGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubm9zaWRhc2VzLyptZXRhYm9saXNtPC9rZXl3b3JkPjxr
ZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtcy8qdGhlcmFweTwv
a2V5d29yZD48a2V5d29yZD5OZXV0cm9wZW5pYS9jb21wbGljYXRpb25zL2V0aW9sb2d5PC9rZXl3
b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48L2tleXdv
cmRzPjxkYXRlcz48eWVhcj4yMDAyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByIDE8L2RhdGU+
PC9wdWItZGF0ZXM+PC9kYXRlcz48YWNjZXNzaW9uLW51bT4xMTkxOTI1MDwvYWNjZXNzaW9uLW51
bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L2Vu
dHJlei9xdWVyeS5mY2dpP2NtZD1SZXRyaWV2ZSZhbXA7ZGI9UHViTWVkJmFtcDtkb3B0PUNpdGF0
aW9uJmFtcDtsaXN0X3VpZHM9MTE5MTkyNTA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9y
ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE.DATA [6-8], and it is possible that the diagnostic properties of the tests may differ between adult and pediatric populations, which in turn, will have important implications for epidemiological studies as well as for the clinical care of immunocompromised children.The objective of this systematic review and meta-analysis was determine whether GM, BG, or fungal PCR are useful tools to detect IFD in pediatric cancer or HSCT patients as screening tools during neutropenia / severe immunosuppression, or as diagnostic tools in patients who present with FN or symptoms suggestive for IFD.METHODSThis analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for reporting ADDIN EN.CITE <EndNote><Cite><Author>Moher</Author><Year>2015</Year><RecNum>7</RecNum><DisplayText>[9]</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="eerwsxpwdzzarnext0jxw006ez0aa005w25s" timestamp="0">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Moher, D.</author><author>Shamseer, L.</author><author>Clarke, M.</author><author>Ghersi, D.</author><author>Liberati, A.</author><author>Petticrew, M.</author><author>Shekelle, P.</author><author>Stewart, L. A.</author></authors></contributors><auth-address>Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada. dmoher@ohri.ca.</auth-address><titles><title>Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement</title><secondary-title>Syst Rev</secondary-title></titles><pages>1</pages><volume>4</volume><edition>2015/01/03</edition><keywords><keyword>Access to Information</keyword><keyword>Checklist</keyword><keyword>Evidence-Based Medicine</keyword><keyword>Guideline Adherence</keyword><keyword>Humans</keyword><keyword>Meta-Analysis as Topic</keyword><keyword>Publishing/organization & administration/ standards</keyword><keyword>Quality Control</keyword><keyword>Review Literature as Topic</keyword></keywords><dates><year>2015</year></dates><isbn>2046-4053 (Electronic)
2046-4053 (Linking)</isbn><accession-num>25554246</accession-num><urls></urls><custom2>4320440</custom2><electronic-resource-num>10.1186/2046-4053-4-1</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[9]. Data Sources and SearchesWe used the Ovid SP platform to search MEDLINE, MEDLINE In-Process and Embase and the Wiley platform to search Cochrane Central Register of Controlled Trials for articles indexed up to March 11, 2016. The search strategy included the Medical Subject Heading terms and text words which identified children and adolescents with cancer or undergoing HSCT in which GM, BG or fungal PCR were evaluated as biomarkers to detect IFD. The search is available as Appendix 1. The set was limited to studies published in 1980 or more recently. There was no restriction by language. Study SelectionEligibility criteria for the studies were defined a priori and were as follows: (1) Subjects were children or adolescents with cancer or were HSCT recipients; (2) The manuscript was a fully published primary study; (3) The study evaluated GM, BG or fungal PCR including Aspergillus PCR in blood, BAL or CSF since these sources are included in the EORTC/MSG criteria,; (4) The publication included the number of patients with IFD. Reasons for excluding studies were the following: (1) Not a full text publication; (2) Not all included patients were pediatric patients (defined as age < 25 years); (3) Less than 50% of patients had cancer or were undergoing HSCT; (4) The study did not evaluate one of the chosen biomarkers for the detection of IFD; (5) The study did not have a control group (patients without IFD); (6) Less than 5 patients with IFD were evaluated; and (7) Pneumocystis jirovecii was the only fungus examined. There was no restriction by study design as long as the eligibility criteria were met.Two reviewers (PR and LS) independently evaluated the titles and abstracts of publications identified by the search strategy and any potentially relevant publication was retrieved in full. Each full text paper was evaluated by two reviewers (TL, PR or LS) and final inclusion of a study into the systematic review required agreement by the two reviewers. Agreement of study inclusion between the two reviewers was evaluated using the kappa statistic; agreement was defined as slight (0 to 20%), fair (21 to 40%), moderate (41 to 60%), substantial (61 to 80%) or almost perfect (81 to 100%) ADDIN EN.CITE <EndNote><Cite><Author>Koch</Author><Year>1977</Year><RecNum>8</RecNum><DisplayText>[10]</DisplayText><record><rec-number>8</rec-number><foreign-keys><key app="EN" db-id="eerwsxpwdzzarnext0jxw006ez0aa005w25s" timestamp="0">8</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Koch, G. G.</author><author>Landis, J. R.</author><author>Freeman, J. L.</author><author>Freeman, D. H., Jr.</author><author>Lehnen, R. C.</author></authors></contributors><titles><title>A general methodology for the analysis of experiments with repeated measurement of categorical data</title><secondary-title>Biometrics</secondary-title></titles><pages>133-58</pages><volume>33</volume><number>1</number><edition>1977/03/01</edition><keywords><keyword>Drug Evaluation/ methods</keyword><keyword>Humans</keyword><keyword>Statistics as Topic</keyword></keywords><dates><year>1977</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0006-341X (Print)
0006-341X (Linking)</isbn><accession-num>843570</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[10]. Data Abstraction and Methodological ApproachTwo reviewers (TL, PR or LS) abstracted all data in duplicate and any discrepancies were resolved by consensus. The primary variables of interest were sensitivity, specificity, positive predictive value and negative predictive value of the biomarkers to detect IFD. The criteria used to declare a biomarker result as positive varied between studies and between biomarkers. We attempted to standardize definitions so that studies were comparable. Data were preferentially reported when a positive GM, BG or PCR test required only one positive result with the threshold being ≥ 0.5 index for GM and ≥ 80 pg/mL for BG. Preferentially, the criteria used to define IFD or IA were according to EORTC/MSG, either in the original or in the revised version PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bc2Npb2dsdTwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bc2Npb2dsdTwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+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ADDIN EN.CITE.DATA [5, 11], and an IFD case was defined as proven or probable IFD wherever possible. However, some studies grouped proven, probable and possible IFD together and in these cases, the results were presented in this fashion with a notation of the analyzed IFD classification approach. All analyses were stratified by biomarker and then stratified based upon the setting, namely as screening tests for patients without signs and symptoms of infection throughout therapy, neutropenia or GVHD versus as diagnostic tests evaluating patients with signs and symptoms of infection, such as FN. We also stratified by specimen source, namely blood, BAL or CSF.Study-level factors collected included years of study publication and enrollment, country of study conduct, patient age range, patient population (cancer, HSCT or both), study design, whether biomarker was reported to clinicians and clinical indication for testing. We also recorded the frequency of specimen collection in the case of blood testing, antifungal prophylaxis, whether IFD was defined using the EORTC/MSG criteria and the definition of a positive biomarker used in our analysis. The prevalence of proven or probable IFD was also determined for each study. Assessment of Study QualityStudy quality was abstracted by two reviewers (TL, PR or LS) and any discrepancies were resolved by consensus. Study quality was assessed using QUADAS-2 for review of diagnostic tests ADDIN EN.CITE <EndNote><Cite><Author>Whiting</Author><Year>2011</Year><RecNum>9</RecNum><DisplayText>[12]</DisplayText><record><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="eerwsxpwdzzarnext0jxw006ez0aa005w25s" timestamp="0">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Whiting, P. F.</author><author>Rutjes, A. W.</author><author>Westwood, M. E.</author><author>Mallett, S.</author><author>Deeks, J. J.</author><author>Reitsma, J. B.</author><author>Leeflang, M. M.</author><author>Sterne, J. A.</author><author>Bossuyt, P. M.</author><author>Quadas- Group</author></authors></contributors><auth-address>University of Bristol, United Kingdom. penny.whiting@bristol.ac.uk</auth-address><titles><title>QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies</title><secondary-title>Ann Intern Med</secondary-title><alt-title>Annals of internal medicine</alt-title></titles><pages>529-36</pages><volume>155</volume><number>8</number><keywords><keyword>Bias (Epidemiology)</keyword><keyword>*Diagnosis</keyword><keyword>Evidence-Based Medicine</keyword><keyword>Humans</keyword><keyword>Patient Selection</keyword><keyword>Quality Control</keyword><keyword>*Questionnaires</keyword><keyword>Reference Standards</keyword><keyword>*Review Literature as Topic</keyword><keyword>Time Factors</keyword></keywords><dates><year>2011</year><pub-dates><date>Oct 18</date></pub-dates></dates><isbn>1539-3704 (Electronic)
0003-4819 (Linking)</isbn><accession-num>22007046</accession-num><urls><related-urls><url>;[12]. Elements were: patient selection (could selection of patients have introduced bias); index test (could the conduct or interpretation of the test have introduced bias); reference standard (could conduct or interpretation of the reference standard have introduced bias); and flow and timing (were all patients included in the analysis). These elements were rated at low, high and unclear risk of bias.Statistical MethodsThe true positive, false positive, false negative and true negative rates were abstracted from each study and based upon these results, sensitivity, specificity and predictive values with their 95% confidence intervals (CIs) were calculated. Two analyses were performed, one in which patients with possible IFD were classified as not having IFD and a second analysis in which patients with possible IFD were excluded in the calculation of diagnostic properties of the test. For pooling sensitivity and specificity, bivariate random effects meta-analysis model was employed in order to account for the correlation between these two accuracy measures ADDIN EN.CITE <EndNote><Cite><Author>Reitsma</Author><Year>2005</Year><RecNum>11</RecNum><DisplayText>[13]</DisplayText><record><rec-number>11</rec-number><foreign-keys><key app="EN" db-id="eerwsxpwdzzarnext0jxw006ez0aa005w25s" timestamp="0">11</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Reitsma, J. B.</author><author>Glas, A. S.</author><author>Rutjes, A. W.</author><author>Scholten, R. J.</author><author>Bossuyt, P. M.</author><author>Zwinderman, A. H.</author></authors></contributors><auth-address>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands. j.reitsma@amc.uva.nl</auth-address><titles><title>Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews</title><secondary-title>J Clin Epidemiol</secondary-title><alt-title>Journal of clinical epidemiology</alt-title></titles><pages>982-90</pages><volume>58</volume><number>10</number><keywords><keyword>Data Interpretation, Statistical</keyword><keyword>*Diagnostic Techniques and Procedures</keyword><keyword>Humans</keyword><keyword>*Meta-Analysis as Topic</keyword><keyword>Outcome Assessment (Health Care)/methods</keyword><keyword>ROC Curve</keyword><keyword>Review Literature as Topic</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2005</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>0895-4356 (Print)
0895-4356 (Linking)</isbn><accession-num>16168343</accession-num><urls><related-urls><url>;[13]. For synthesis, we excluded studies which did not use EORTC/MSG criteria to define IFD and studies in which possible IFD had to be considered a positive IFD case as reclassification could not be performed with the data provided. For GM synthesis, we excluded studies which used thresholds other than an OD ≥ 0.5 once or twice, or ≥ 0.7 once, and for BG, we excluded studies that used thresholds other than 80 pg/mL. We did not pool predictive values as this approach is not commonly done in meta-analyses as they depend on prevalence of the disease. Publication bias was not investigated given the nature of the outcome, namely diagnostic properties of individual tests. Analyses were conducted using the SAS statistical program (SAS-PC, version 9.4; SAS Institute Inc, Cary, North Carolina) and R (Foundation for Statistical Computing, Vienna, Austria). RESULTSThe flow of study identification and selection is illustrated in Figure 1. There were 1,532 unique citations identified by the search strategy, of which 55 were retrieved for full-text evaluation. Among these citations, 25 met the eligibility criteria and were included in the systematic review. Reasons for exclusion are described in Figure 1. Agreement of study inclusion between the two reviewers was almost perfect with kappa=92.7% (95% CI 82.7% to 100%). Because the same study could evaluate multiple biomarkers, there were a total of 25 publications presenting 33 separate analyses of the chosen biomarkers. All studies evaluated blood specimens and one of these studies also evaluated the diagnostic properties of BAL GM. Table 1 summarizes the characteristics of the studies evaluating biomarkers in the blood and Appendix 2 includes the detailed data abstracted from each study. Most studies of biomarkers assessed in the blood included both cancer and HSCT patients (18/32, 56%).There were 18 studies enrolling a total of 1,421 patients (184 with proven/probable IFD) that evaluated GM in blood in the pediatric cancer and HSCT setting (Table 2) bmVvcGxhc3RpYyBDb21iaW5lZCBDaGVtb3RoZXJhcHkgUHJvdG9jb2xzL2FlIFtBZHZlcnNlIEVm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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HZWZlbjwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA bmVvcGxhc3RpYyBDb21iaW5lZCBDaGVtb3RoZXJhcHkgUHJvdG9jb2xzL2FlIFtBZHZlcnNlIEVm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ADDIN EN.CITE.DATA [14-31]. Ten studies used GM as a screening test during neutropenic periods or during GVHD. Conversely, 8 studies assessed GM as a diagnostic tool in children with symptoms potentially suggestive of IFD, such as prolonged FN. Overall, the prevalence of IFD ranged from 0 to 30.8% in individual studies. Antifungal prophylaxis was heterogeneous and often not standardized or specified (n=12). Sixteen studies used EORTC/MSG to define IFD or IA and 12 studies could be evaluated using a GM index of 0.5 once or twice or 0.7 once as the threshold. Results of GM evaluation are shown as Table 2 and ordered by prevalence of proven or probable IFD or IA. Diagnostic properties are shown both for when possible IFD was included as a negative case and when patients with possible IFD were excluded from the analysis (where possible). Among the 10 studies in which GM in blood was used to screen for IFD among 100 patients with neutropenia or post HSCT, the following ranges were observed: specificity 50-100%, sensitivity 0-100%, positive predictive value 0-100% and negative predictive value 85-100%. Table 2 also shows the results of GM testing performed as a diagnostic test in 84 patients from 8 studies with the following ranges: specificity 35-100%, positive predictive value 0-100%, sensitivity 14-100% and negative predictive value 70-100%. The only study evaluating GM in BAL reported sensitivity, specificity, positive and negative predictive value for proven/probable IA of 82%, 88%, 82%, and 87%, respectively (data not shown) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5kZSBNb2w8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5kZSBNb2w8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA [16].Table 3 shows the results of the only 3 studies in which BG testing was evaluated in pediatric patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb2x0emU8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb2x0emU8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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 EN.CITE.DATA [19, 29, 32]. These studies included a total of 226 children, 38 of which were diagnosed with proven/probable IFD and reported the following ranges: specificity 29-82%, sensitivity 50-83%, positive predictive value 17-49%, and negative predictive value 84-96%.Table 4 illustrates the 11 studies which evaluated multi-fungal PCR (n=5) or Aspergillus PCR (n=6) in the blood L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy9ibG9vZDwva2V5d29yZD48a2V5d29yZD5Qb2x5bWVy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWlud2FsZDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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==
ADDIN EN.CITE.DATA L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy9ibG9vZDwva2V5d29yZD48a2V5d29yZD5Qb2x5bWVy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ADDIN EN.CITE.DATA [15, 19, 21, 25, 26, 33-38]. These studies included a total of 686 children (86 with proven/probable IFD). Among the 3 studies which applied PCR in the screening setting, the following ranges were observed: specificity 43-85%, sensitivity 11-80%, positive predictive value 20-50%, and negative predictive value 60-96%. When PCR-based assays were used as diagnostic tool during febrile episodes, the following were seen: sensitivity 0-100%, specificity 36-83%, positive predictive value 0-71%, and negative predictive value 88-100%. Notably, in the only study in which anti-mold prophylaxis was applied to all patients, the positive predictive value of the PCR was 0% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5kaGFuaXlhPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5kaGFuaXlhPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE.DATA [33].In general, across all serum biomarkers, predictive values were similar when possible IFD was classified as not having IFD or when patients with possible IFD were excluded from the analysis. In addition, predictive values did not clearly differ based upon use in the screening setting or as a diagnostic test during FN and test characteristics did not systematically improve as disease prevalence increased (Tables 2-4). Table 5 illustrates the pooled sensitivity and specificity by biomarker stratified by clinical setting. For GM evaluated in the screening setting and for diagnostic testing, 5 studies each were appropriate for synthesis based on using EORTC/MSG criteria, use of proven or probable IFD as a case and using appropriate GM thresholds for positivity. For each setting, the pooled sensitivity and specificity (95% CI) for GM were 68% (51-81) and 91% (86-94), and 89% (79-95) and 85% (51-97), respectively. Combining the results of both settings demonstrated a pooled sensitivity of 81% (69-89) and pooled specificity of 88% (75-95) (Table 5). For BG and for PCR-based assays in the screening setting, no synthesis was possible due to the low number of appropriate studies (two and one study, respectively). For the six appropriate studies evaluating PCR-based assays as diagnostic test, the pooled sensitivity and specificity was 76% (62-86) and 58% (42-72) (Table 5). DISCUSSIONOur systematic review and meta-analysis of the fungal biomarkers GM and BG and of PCR-based assays in pediatric cancer and HSCT patients demonstrates that sensitivity, specificity and positive predictive value of these tests were highly variable and generally not robust in both the screening setting and as a diagnostic test in symptomatic patients. However, serum GM negative predictive values were high. Across biomarkers, positive and negative predictive values were similar when patients with possible IFD were classified as not having IFD or when patients with possible IFD were excluded from the analysis. In addition, predictive values did not clearly differ based upon use in the screening or diagnostic testing setting. Only one study which met the inclusion criteria evaluated GM in BAL, and none evaluated fungal biomarkers in the CSF. The great variability in the diagnostic properties of the fungal biomarkers may have been the result of multiple factors. First, there was significant heterogeneity in the study design and study population (for example, the inclusion of children with hematological malignancies and solid tumors and children undergoing allogeneic HSCT; children with and without neutropenia), and a considerable number of studies included only a small number of patients with proven/probable IFD. In addition, the aggressiveness in the use of other diagnostic tools for IFD such as chest CT scan or BAL most likely differed between the study centers and consequently affected the results. For example, in centers not using these tools routinely, patients with true IFD will unlikely meet the criteria for probable or proven IFD, and thus, a true positive GM will be classified as a false positive result. Also, most of the PCR-based assays tested were non-standardized in-house assays which differed in their methodology including specimen source, DNA extraction methods, amplification target sequences or amplification. When pediatric and adult studies were compared, the performance of the biomarkers seems to be similar (Table 5) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWVmbGFuZzwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWVmbGFuZzwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+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==
ADDIN EN.CITE.DATA [39-41]. This is important to note as children and adults differ in their underlying malignancies and treatment schedules as well as in immunity and immune reconstitution after chemotherapy ADDIN EN.CITE <EndNote><Cite><Author>Sung</Author><Year>2011</Year><RecNum>8979</RecNum><DisplayText>[42]</DisplayText><record><rec-number>8979</rec-number><foreign-keys><key app="EN" db-id="pzfzsxppfv29xheprrspv9fova255v520aws" timestamp="1434398728">8979</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sung, L.</author><author>Phillips, R.</author><author>Lehrnbecher, T.</author></authors></contributors><titles><title>Time for paediatric febrile neutropenia guidelines - children are not little adults</title><secondary-title>Eur J Cancer</secondary-title><alt-title>European journal of cancer</alt-title></titles><periodical><full-title>Eur J Cancer</full-title><abbr-1>European journal of cancer</abbr-1></periodical><alt-periodical><full-title>Eur J Cancer</full-title><abbr-1>European journal of cancer</abbr-1></alt-periodical><pages>811-3</pages><volume>47</volume><number>6</number><keywords><keyword>Age Factors</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Fever/*therapy</keyword><keyword>Humans</keyword><keyword>Infant</keyword><keyword>Neutropenia/*therapy</keyword><keyword>*Practice Guidelines as Topic</keyword></keywords><dates><year>2011</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>1879-0852 (Electronic)
0959-8049 (Linking)</isbn><accession-num>21371884</accession-num><urls><related-urls><url>;[42], all of which may influence the performance of diagnostic tests as demonstrated in animal studies PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZXRyYWl0aWVuZTwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZXRyYWl0aWVuZTwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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 EN.CITE.DATA [43]. In order to determine the value of a test, it is important to consider how biomarkers may be used clinically. As a diagnostic tool, a high positive predictive value is important which may prompt additional diagnostics including imaging studies or the initiation of antifungal therapy, whereas in the screening setting, a high negative predictive value is needed. Unfortunately, for all the biomarkers evaluated in our study, positive predictive values were highly variable and generally poor and unlikely to be clinically useful. The only consistently favorable property was a high negative predictive value with blood GM. However, given that GM can only identify Aspergillus species but not other molds, the high negative predictive value is of limited clinical value since clinicians may not be willing to withhold antifungal therapy because of the risk of non-Aspergillus fungal infections. On the other hand, there are arguments which support the use of biomarkers. Whereas the positive predictive values are not reassuring and preclude a recommendation for routine utilization, the upper limits of the positive predictive values reported in some studies may be enough of an increase from the pre-test probability for some clinicians to consider utilizing them. Unfortunately, none of the studies systematically assessed biomarkers in the setting of possible IFD, which may be a more difficult scenario clinically for decision making, but which might help to assess the local epidemiology of IFD. The strength of our systematic review is its comprehensive evaluation of all pediatric studies assessing GM, BG and PCR-based assays for the early detection of IFD. The review also included data from studies not published in English, which is important due to the paucity of data in the pediatric population. Importantly, we present data in different clinical settings separately, namely in the screening and diagnostic testing settings, and show positive and negative predictive values relative to each study’s IFD prevalence (i.e. pre-test probability). However, our results must be interpreted in light of study limitations. First, studies were highly heterogeneous which limits the interpretation of the pooled data. Second, fungal prophylaxis varied or was not specified which is important as studies in adults demonstrated that the administration of anti-mold active compounds decreases the ability of biomarkers to detect IFD PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWVmbGFuZzwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWVmbGFuZzwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+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==
ADDIN EN.CITE.DATA [39, 44, 45]. Finally, studies that show poor performance of biomarkers may be more difficult to publish, leading to an overestimation of the performance of biomarkers. In conclusion, poor positive predictive values were observed for serum GM, BG and PCR-based assays which preclude their application as screening tools during neutropenia or periods of GVHD and as a diagnostic tools in patients presenting with FN or symptoms suggestive for IFD. While the negative predictive value of GM was high, the inability of a negative GM to exclude non-Aspergillus molds may also limit usefulness. Future work could address the usefulness of combinations of biomarkers in pediatric cancer and HSCT, and should focus on specific clinical scenarios with higher pre-test probability of IFD such as children with possible IFD. AcknowledgmentsThe assistance of Elizabeth Uleryk, Library Scientist, with the literature searches and the administrative assistance of Sandra Cabral are gratefully acknowledged.Conflict of interest:TL received research grants from Gilead, is a consultant for Basilea, Gilead, Merck/MSD, and received lecture honoraria from Astellas, Gilead, Merck/MSD, and Pfizer. BF received research grant support from Pfizer, Merck, and Ausun Biopharma. BTF received research grant support from Pfizer, Merck, and Ausun Biopharma. EC is a consultant for Basilea, Gilead, Astellas, Pfizer and received lecture honoraria from Astellas, Gilead and Pfizer. AHG received grants from Gilead and Merck, Sharp & Dohme and Pfizer; is a consultant for Amplyx, Astellas, Basilea, Gilead, Merck, Sharp & Dohme and Schering-Plough, and served at the speakers? bureau of Astellas, Basilea, Gilead, Merck, Sharp & Dohme, Pfizer, Schering-Plough and Zeneus/Cephalon. WJS is a consultant for Amplyx, Astellas, Cidara and Merck. TEZ received research funding from Merck and Cubist and is a consultant for Merck, Pfizer, Astellas Pharma, and Cubist. All other authors: no conflicts of interest.ReferencesTable 1: Characteristics of Studies that Evaluated Fungal Biomarkers in BloodCharacteristic and StrataNo. (%) GM N=18No. (%) BDG (N=3)No. (%)PCR (N=11)Study Population Diagnosis Cancer3 (17%)1 (33%)5 (45%) HSCT3 (17%)1 (33%)1 (9%) Both12 (67%)1 (33%)5 (45%)Year Publication ≥ 201010 (56%)2 (67%)4 (36%)Indication for Testing Screening Test10 (56%)2 (67%)3 (27%) Diagnostic Test8 (44%)1 (33%)8 (73%)Study Design Prospective cohort12 (67%)3 (100%)7 (64%) Retrospective cohort6 (33%)04 (36%)Assay Results Reported to Clinicians Yes5 (28%)04 (36%) No7 (39%)2 (67%)5 (45%) Uncertain6 (33%)1 (33%)2 (18%)Anti-mold Prophylaxis001 (9%)Invasive Fungal Disease Outcome Analyzed Proven or probable15 (83%)3 (100%)9 (82%) Proven, probable or possible3 (17%)02 (18%)EORTC/MSG Gold Standard16 (89%)3 (100%)9 (82%)Number of Samples Required for Positivity One11 (61%)3 (100%)9 (82%) Two5 (28%)02 (18%) One or two depending on threshold2 (11%)00Prevalence of Proven or Probable IFD ≥ 5%11 (61%)3 (100%) 8 (73%) ≥ 10%8 (44%)3 (100%)5 (45%)Low Risk of Bias Patient selection 7 (39%)1 (33%)3 (27%) Index test 13 (72%)1 (33%)8 (73%) Reference standard4 (22%)2 (67%)1 (9%) Flow and timing17 (94%)3 (100)10 (91%)Abbreviation: GM – galactomannan; BDG – beta-D-glucan; PCR – polymerase chain reaction; HSCT – hematopoietic stem cell transplantation; EORTC/MSG – European Organisation for Research and Treatment in Cancer/ Mycoses Study GroupTable 2: Test Characteristics of Galactomannan in Blood in Children and Adolescents with Cancer and Hematopoietic Stem Cell Transplant RecipientsFirst AuthorNo. Patients IFD Definition AnalyzedPrevalenceSpecificitySensitivityPositive PredictiveNegative PredictiveSpecificitySensitivityPositive PredictiveNegative PredictivePossible Included as Negative IFD *Possible ExcludedScreening Hayden56Prov/Prob IA 30.487% (73-96)65% (38-86)69% (41-89)85% (70-94)87% (73-96)65% (38-86)69% (41-89)85% (70-94)Rohrlich37Prov/Prob IA 27.093% (76-99)100% (69-100)83% (52-98)100% (86-100)Koltze34Prov/Prob IFD17.6100% (88-100)83% (36-100)100% (48-100)97% (82-100)100% (88-100)83% (36-100)100% (48-100)97% (82-100)Badiee62Prov/Prob IA16.190% (79-97)90% (56-100)64% (35-87)98% (89-100)92% (75-99)90% (56-100)82% (48-98)96% (80-100)Gefen46Prov/Prob/Poss IA8.766% (49-80)80% (28-99)22% (6-48)96% (82-100)Tabone76Prov/Prob IA7.987% (77-94)100% (54-100)40% (16-68)100% (94-100)90% (80-96)100% (54-100)46% (19-75)100% (94-100)Bialek17Prov/Prob/Poss IA5.050% (23-77)100% (29-100)30% (7-65)100% (59-100)Hovi98 (117 episodes)Prov/Prob IFD2.090% (84-95)50% (1-99)8% (0-38)99% (95-100)93% (86-97)50% (1-99)14% (0-58)99% (94-100)Steinbach64Prov/Prob IA1.687% (77-94)0% (0-98)0% (0-37)98% (90-100)87% (77-94)0% (0-98)0% (0-37)98% (90-100)Fisher198Prov/Prob IA0.595% (91-98)0% (0-98)0% (0-31)99% (97-100)Diagnostic Testing El-Mahallawy91Prov/Prob IA30.849% (36-62)79% (59-92)41% (28-55)84% (68-94)61% (46-75)79% (59-92)54% (37-69)83% (67-94)Choi99Prov/Prob IA23.282% (70-90)91% (72-99)66% (47-81)96% (87-100)82% (70-90)91% (72-99)66% (47-81)96% (87-100)Dinand145 (211 episodes)Prov/Prob IA13.872% (65-78)95% (75-100)26% (17-38)99% (96-100)80% (73-85)95% (75-100)36% (23-50)99% (96-100)de Mol38Prov/Prob IA10.9100% (85-10087% (60-98)100% (75-100)92% (74-99)100% (74-100)87% (60-98)100% (75-100)86% (57-98)Armenian68Prov/Prob/Poss IA 4.498% (88-100)14% (3-35)75% (19-99)70% (58-81)98% (88-100)100% (29-100)75% (19-99)100% (92-100)Castagnola119 (195 episodes)Prov/Prob IA3.698% (95-100)100% (59-100)70% (35-93)100% (98-100)98% (95-100)100% (59-100)70% (35-93)100% (98-100)Jha78 (100 episodes)Prov/Prob IA2.035% (25-45)100% (16-100)3% (0-11)100% (90-100)39% (28-51)100% (16-100)4% (1-14)100% (88-100)Reinwald95 (253 episodes)Prov/Prob IA0.090% (82-96)NC0% (0-37)100% (95-100)????Abbreviations: IFD – invasive fungal disease; IA – invasive aspergillosis; Prov – proven; Prob – probable; Poss – possible; NC- not calculable* In studies in which possible IFD or IA were included as a case and data were not provided to permit re-calculation, possibles could not be included as a negative control (baseline analysis). However, these studies were excluded from GM synthesis (see Methods) Table 3: Test Characteristics of Beta-D-Glucan in Blood in Children and Adolescents with Cancer and Hematopoietic Stem Cell Transplant RecipientsFirst AuthorNo. Patients IFD Definition AnalyzedPrevalenceSpecificitySensitivityPositive PredictiveNegative PredictiveSpecificitySensitivityPositive PredictiveNegative PredictivePossible Included as Negative IFDPossible ExcludedKoltze34Prov/Prob IFD17.629% (13-49)83% (36-100)20% (7-41)89% (52-100)29% (13-49)83% (36-100)20% (7-41)89% (52-100)Zhao130Prov/Prob IFD16.982% (74-89)82% (60-95)49% (32-66)96% (89-99)Badiee62Prov/Prob IA16.152% (38-66)50% (19-81)17% (6-35)84% (67-95)46% (27-67)50% (19-81)26% (9-51)71% (44-90)Abbreviations: IFD – invasive fungal disease; IA – invasive aspergillosis; Prov – proven; Prob – probable; Poss – possible Table 4: Test Characteristics of Fungal Polymerase Chain Reaction in Blood in Children and Adolescents with Cancer and Hematopoietic Stem Cell Transplant RecipientsFirst AuthorNo. Patients IFD Definition AnalyzedPrevalenceSpecificitySensitivityPositive PredictiveNegative PredictiveSpecificitySensitivityPositive PredictiveNegative PredictivePossible Included as Negative IFD*Possible ExcludedScreeningBadiee62Prov/Prob IA16.185% (72-93)80% (44-97)50% (25-75)96% (85-99)96% (80-100)80% (44-97)89% (52-100)93% (76-99)Bialek17Prov/Prob/Poss IA 5.043% (18-71)67% (9-99)20% (3-56)86% (42-100)Armenian68Prov/Prob/Poss IA 4.479% (61-91)11% (1-33)22% (3-60)60% (44-75)Diagnostic TestLin42 (83 episodes)Fungemia40.572% (51-88)100% (80-100)71% (49-87)100% (81-100)72% (51-88)100% (80-100)71% (49-87)100% (81-100)El-Mahallawy91Prov/Prob IA30.883% (71-91)75% (55-89)66% (47-81)88% (77-95)92% (80-98)75% (55-89)84% (64-95)87% (74-94)Dendis24Prov/Prob IFD20.874% (49-91)100% (48-100)50% (19-81)100% (77-100)74% (49-91)100% (48-100)50% (19-81)100% (77-100)Cesaro62Prov/Prob IA12.937% (24-51)88% (47-100)17% (7-32)95% (76-100)37% (24-51)88% (47-100)17% (7-32)95% (76-100)Hummel71Prov/Prob IA7.074% (61-84)80% (28-99)19% (5-42)98% (89-100)81% (64-93)80% (28-99)40% (12-74)96% (81-100)Landlinger125 (150 episodes) Prov/Prob IFD6.757% (49-65)100% (69-100)14% (7-25)100% (95-100)64% (55-73)100% (69-100)19% (9-31)100% (95-100)Mandhaniya29Prov/Prob IA3.436% (19-56)0% (0-98)0% (0-19)91% (59-100)33% (16-55)0% (0-98)0% (0-21)89% (52-100)Reinwald95 (253 episodes)Prov/Prob IA0.054% (43-64)NC0% (0-8)100% (93-100)53% (39-66)NC0% (0-13)100% (88-100)Abbreviations: IFD – invasive fungal disease; IA – invasive aspergillosis; Prov – proven; Prob – probable; Poss – possible; NC- not calculable* In studies in which possible IFD or IA were included as a case and data were not provided to permit re-calculation, possibles could not be included as a negative control (baseline analysis).Table 5: Pooled Sensitivity and Specificity for the Biomarkers Galactomannan, Beta-D-Glucan and PCR-based Assays in Children and Adults?Pediatrics*Adults?SensitivitiySpecificitySensitivitiy1Specificity1Galactomannan???????? Screening (n=5)68%(51 to 81)91%(86 to 94)?? Diagnostic Test (n=5)89%(79 to 95)85%(51 to 97)?? Total81% (69 to 89)88%(75 to 95)82%(73 to 90) ADDIN EN.CITE <EndNote><Cite><Author>Leeflang</Author><Year>2015</Year><RecNum>9818</RecNum><DisplayText>[39]</DisplayText><record><rec-number>9818</rec-number><foreign-keys><key app="EN" db-id="pzfzsxppfv29xheprrspv9fova255v520aws" timestamp="1458478734">9818</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Leeflang, M. M.</author><author>Debets-Ossenkopp, Y. J.</author><author>Wang, J.</author><author>Visser, C. E.</author><author>Scholten, R. J.</author><author>Hooft, L.</author><author>Bijlmer, H. A.</author><author>Reitsma, J. B.</author><author>Zhang, M.</author><author>Bossuyt, P. M.</author><author>Vandenbroucke-Grauls, C. M.</author></authors></contributors><auth-address>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, P.O. Box 22700, Amsterdam, Netherlands, 1100 DE.</auth-address><titles><title>Galactomannan detection for invasive aspergillosis in immunocompromised patients</title><secondary-title>Cochrane Database Syst Rev</secondary-title><alt-title>The Cochrane database of systematic reviews</alt-title></titles><periodical><full-title>Cochrane Database Syst Rev</full-title><abbr-1>The Cochrane database of systematic reviews</abbr-1></periodical><alt-periodical><full-title>Cochrane Database Syst Rev</full-title><abbr-1>The Cochrane database of systematic reviews</abbr-1></alt-periodical><pages>CD007394</pages><volume>12</volume><dates><year>2015</year></dates><isbn>1469-493X (Electronic)
1361-6137 (Linking)</isbn><accession-num>26716951</accession-num><urls><related-urls><url>;[39]81%(72 to 90) ADDIN EN.CITE <EndNote><Cite><Author>Leeflang</Author><Year>2015</Year><RecNum>9818</RecNum><DisplayText>[39]</DisplayText><record><rec-number>9818</rec-number><foreign-keys><key app="EN" db-id="pzfzsxppfv29xheprrspv9fova255v520aws" timestamp="1458478734">9818</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Leeflang, M. M.</author><author>Debets-Ossenkopp, Y. J.</author><author>Wang, J.</author><author>Visser, C. E.</author><author>Scholten, R. J.</author><author>Hooft, L.</author><author>Bijlmer, H. A.</author><author>Reitsma, J. B.</author><author>Zhang, M.</author><author>Bossuyt, P. M.</author><author>Vandenbroucke-Grauls, C. M.</author></authors></contributors><auth-address>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, P.O. Box 22700, Amsterdam, Netherlands, 1100 DE.</auth-address><titles><title>Galactomannan detection for invasive aspergillosis in immunocompromised patients</title><secondary-title>Cochrane Database Syst Rev</secondary-title><alt-title>The Cochrane database of systematic reviews</alt-title></titles><periodical><full-title>Cochrane Database Syst Rev</full-title><abbr-1>The Cochrane database of systematic reviews</abbr-1></periodical><alt-periodical><full-title>Cochrane Database Syst Rev</full-title><abbr-1>The Cochrane database of systematic reviews</abbr-1></alt-periodical><pages>CD007394</pages><volume>12</volume><dates><year>2015</year></dates><isbn>1469-493X (Electronic)
1361-6137 (Linking)</isbn><accession-num>26716951</accession-num><urls><related-urls><url>;[39]?????????Beta-D-Glucan (n=2)NANA76.8%(67.1 to 84.3) ADDIN EN.CITE <EndNote><Cite><Author>Karageorgopoulos</Author><Year>2011</Year><RecNum>7077</RecNum><DisplayText>[40]</DisplayText><record><rec-number>7077</rec-number><foreign-keys><key app="EN" db-id="pzfzsxppfv29xheprrspv9fova255v520aws" timestamp="0">7077</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Karageorgopoulos, D. E.</author><author>Vouloumanou, E. K.</author><author>Ntziora, F.</author><author>Michalopoulos, A.</author><author>Rafailidis, P. I.</author><author>Falagas, M. E.</author></authors></contributors><auth-address>Alfa Institute of Biomedical Sciences, Laikon General Hospital, Athens, Greece. m.falagas@aibs.gr</auth-address><titles><title>beta-D-glucan assay for the diagnosis of invasive fungal infections: a meta-analysis</title><secondary-title>Clin Infect Dis</secondary-title></titles><periodical><full-title>Clin Infect Dis</full-title><abbr-1>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</abbr-1></periodical><pages>750-70</pages><volume>52</volume><number>6</number><keywords><keyword>Biological Markers/*blood</keyword><keyword>Clinical Laboratory Techniques/*methods</keyword><keyword>Humans</keyword><keyword>Mycoses/*diagnosis</keyword><keyword>Plasma/chemistry</keyword><keyword>ROC Curve</keyword><keyword>Sensitivity and Specificity</keyword><keyword>Serum/chemistry</keyword><keyword>beta-Glucans/*blood</keyword></keywords><dates><year>2011</year><pub-dates><date>Mar</date></pub-dates></dates><accession-num>21367728</accession-num><urls><related-urls><url>;[40]85.3%(79.6 to 89.7) ADDIN EN.CITE <EndNote><Cite><Author>Karageorgopoulos</Author><Year>2011</Year><RecNum>7077</RecNum><DisplayText>[40]</DisplayText><record><rec-number>7077</rec-number><foreign-keys><key app="EN" db-id="pzfzsxppfv29xheprrspv9fova255v520aws" timestamp="0">7077</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Karageorgopoulos, D. E.</author><author>Vouloumanou, E. K.</author><author>Ntziora, F.</author><author>Michalopoulos, A.</author><author>Rafailidis, P. I.</author><author>Falagas, M. E.</author></authors></contributors><auth-address>Alfa Institute of Biomedical Sciences, Laikon General Hospital, Athens, Greece. m.falagas@aibs.gr</auth-address><titles><title>beta-D-glucan assay for the diagnosis of invasive fungal infections: a meta-analysis</title><secondary-title>Clin Infect Dis</secondary-title></titles><periodical><full-title>Clin Infect Dis</full-title><abbr-1>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</abbr-1></periodical><pages>750-70</pages><volume>52</volume><number>6</number><keywords><keyword>Biological Markers/*blood</keyword><keyword>Clinical Laboratory Techniques/*methods</keyword><keyword>Humans</keyword><keyword>Mycoses/*diagnosis</keyword><keyword>Plasma/chemistry</keyword><keyword>ROC Curve</keyword><keyword>Sensitivity and Specificity</keyword><keyword>Serum/chemistry</keyword><keyword>beta-Glucans/*blood</keyword></keywords><dates><year>2011</year><pub-dates><date>Mar</date></pub-dates></dates><accession-num>21367728</accession-num><urls><related-urls><url>;[40]?????????PCR ????? Screening (n=1)NANA?? Diagnostic Test (n=6)76%(62 to 86)58%(42 to 72)?? Total80.5%(73 to 86.3) ADDIN EN.CITE <EndNote><Cite><Author>Cruciani</Author><Year>2015</Year><RecNum>92</RecNum><DisplayText>[41]</DisplayText><record><rec-number>92</rec-number><foreign-keys><key app="EN" db-id="eerwsxpwdzzarnext0jxw006ez0aa005w25s" timestamp="0">92</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cruciani, M.</author><author>Mengoli, C.</author><author>Loeffler, J.</author><author>Donnelly, P.</author><author>Barnes, R.</author><author>Jones, B. L.</author><author>Klingspor, L.</author><author>Morton, O.</author><author>Maertens, J.</author></authors></contributors><auth-address>Center of Community Medicine and Infectious Diseases Service, ULSS 20 Verona, Via Germania, 20, Verona, Italy, 37135.</auth-address><titles><title>Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people</title><secondary-title>Cochrane Database Syst Rev</secondary-title><alt-title>The Cochrane database of systematic reviews</alt-title></titles><pages>CD009551</pages><volume>10</volume><keywords><keyword>Aspergillosis/blood/*diagnosis</keyword><keyword>Cohort Studies</keyword><keyword>Data Accuracy</keyword><keyword>False Negative Reactions</keyword><keyword>False Positive Reactions</keyword><keyword>Humans</keyword><keyword>*Immunocompromised Host</keyword><keyword>Opportunistic Infections/blood/*diagnosis</keyword><keyword>Polymerase Chain Reaction/*methods</keyword><keyword>Predictive Value of Tests</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2015</year></dates><isbn>1469-493X (Electronic)
1361-6137 (Linking)</isbn><accession-num>26424726</accession-num><urls><related-urls><url>;[41]78.5%(67.8 to 86.4) ADDIN EN.CITE <EndNote><Cite><Author>Cruciani</Author><Year>2015</Year><RecNum>92</RecNum><DisplayText>[41]</DisplayText><record><rec-number>92</rec-number><foreign-keys><key app="EN" db-id="eerwsxpwdzzarnext0jxw006ez0aa005w25s" timestamp="0">92</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cruciani, M.</author><author>Mengoli, C.</author><author>Loeffler, J.</author><author>Donnelly, P.</author><author>Barnes, R.</author><author>Jones, B. L.</author><author>Klingspor, L.</author><author>Morton, O.</author><author>Maertens, J.</author></authors></contributors><auth-address>Center of Community Medicine and Infectious Diseases Service, ULSS 20 Verona, Via Germania, 20, Verona, Italy, 37135.</auth-address><titles><title>Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people</title><secondary-title>Cochrane Database Syst Rev</secondary-title><alt-title>The Cochrane database of systematic reviews</alt-title></titles><pages>CD009551</pages><volume>10</volume><keywords><keyword>Aspergillosis/blood/*diagnosis</keyword><keyword>Cohort Studies</keyword><keyword>Data Accuracy</keyword><keyword>False Negative Reactions</keyword><keyword>False Positive Reactions</keyword><keyword>Humans</keyword><keyword>*Immunocompromised Host</keyword><keyword>Opportunistic Infections/blood/*diagnosis</keyword><keyword>Polymerase Chain Reaction/*methods</keyword><keyword>Predictive Value of Tests</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2015</year></dates><isbn>1469-493X (Electronic)
1361-6137 (Linking)</isbn><accession-num>26424726</accession-num><urls><related-urls><url>;[41]*NA too few studies to synthesize-66675504825Potentially relevant references identified (n=1,833)Citations screened by title/abstract (n=1,532)Full text references retrieved for detailed evaluation (n=55)Duplicates removed (n=301)Citations excluded as did not meet eligibility criteria (n=1,477) Studies included in systematic review (n=25)Excluded (n=30) Not a full text publication of a primary study (n=1) Not pediatric patients (age < 25 years) (n=9) Less than 50% of patients had cancer (n=7) Less than 5 patients (n=1) Number of patients with IFI not described (n=4) Does not evaluate one of the fungal biomarker tests (n=7) Not retrievable (n=1)00Potentially relevant references identified (n=1,833)Citations screened by title/abstract (n=1,532)Full text references retrieved for detailed evaluation (n=55)Duplicates removed (n=301)Citations excluded as did not meet eligibility criteria (n=1,477) Studies included in systematic review (n=25)Excluded (n=30) Not a full text publication of a primary study (n=1) Not pediatric patients (age < 25 years) (n=9) Less than 50% of patients had cancer (n=7) Less than 5 patients (n=1) Number of patients with IFI not described (n=4) Does not evaluate one of the fungal biomarker tests (n=7) Not retrievable (n=1)Figure 1 28448090995500 ADDIN EN.REFLIST 1Johnston DL, Lewis V, Yanofsky R, et al. (2013) Invasive fungal infections in paediatric acute myeloid leukaemia. Mycoses 56: 482-487.2Steinbach WJ, Roilides E, Berman D, et al. (2012) Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J 31: 1252-1257.3Wattier RL, Dvorak CC, Hoffman JA, et al. (2015) A prospective, international cohort study of invasive mold infections in children. J Pediatric Infect Dis Soc 4: 313-322.4Ambasta A, Carson J, Church DL. (2015) The use of biomarkers and molecular methods for the earlier diagnosis of invasive aspergillosis in immunocompromised patients. Med Mycol 53: 531-557.5De Pauw B, Walsh TJ, Donnelly JP, et al. (2008) Revised definitions of invasive fungal disease from the european organization for research and treatment of cancer/invasive fungal infections cooperative group and the national institute of allergy and infectious diseases mycoses study group (eortc/msg) consensus group. Clin Infect Dis 46: 1813-1821.6Groll AH, Castagnola E, Cesaro S, et al. (2014) Fourth european conference on infections in leukaemia (ecil-4): Guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation. Lancet Oncol 15: e327-340.7Buchheidt D, Reinwald M, Spiess B, et al. (2016) Biomarker-based diagnostic work-up of invasive pulmonary aspergillosis in immunocompromised paediatric patients--is aspergillus pcr appropriate? Mycoses 59: 67-74.8Herbrecht R, Letscher-Bru V, Oprea C, et al. (2002) Aspergillus galactomannan detection in the diagnosis of invasive aspergillosis in cancer patients. J Clin Oncol 20: 1898-1906.9Moher D, Shamseer L, Clarke M, et al. (2015) Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015 statement. Syst Rev 4: 1.10Koch GG, Landis JR, Freeman JL, Freeman DH, Jr., Lehnen RC. (1977) A general methodology for the analysis of experiments with repeated measurement of categorical data. Biometrics 33: 133-158.11Ascioglu S, Rex JH, de Pauw B, et al. (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: An international consensus. Clin Infect Dis 34: 7-14.12Whiting PF, Rutjes AW, Westwood ME, et al. (2011) Quadas-2: A revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 155: 529-536.13Reitsma JB, Glas AS, Rutjes AW, Scholten RJ, Bossuyt PM, Zwinderman AH. (2005) Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol 58: 982-990.14Gefen A, Zaidman I, Shachor-Meyouhas Y, et al. (2015) Serum galactomannan screening for diagnosis of invasive pulmonary aspergillosis in children after stem cell transplantation or with high-risk leukemia. Pediatric Hematology & Oncology 32: 146-152.15Reinwald M, Konietzka CA, Kolve H, et al. (2014) Assessment of aspergillus-specific pcr as a screening method for invasive aspergillosis in paediatric cancer patients and allogeneic haematopoietic stem cell recipients with suspected infections. Mycoses 57: 537-543.16de Mol M, de Jongste JC, van Westreenen M, et al. (2013) Diagnosis of invasive pulmonary aspergillosis in children with bronchoalveolar lavage galactomannan. Pediatric Pulmonology 48: 789-796.17Jha AK, Bansal D, Chakrabarti A, Shivaprakash MR, Trehan A, Marwaha RK. (2013) Serum galactomannan assay for the diagnosis of invasive aspergillosis in children with haematological malignancies. Mycoses 56: 442-448.18Choi SH, Kang ES, Eo H, et al. (2013) Aspergillus galactomannan antigen assay and invasive aspergillosis in pediatric cancer patients and hematopoietic stem cell transplant recipients. Pediatric Blood & Cancer 60: 316-322.19Badiee P, Alborzi A, Karimi M, et al. (2012) Diagnostic potential of nested pcr, galactomannan eia, and beta-d-glucan for invasive aspergillosis in pediatric patients. Journal of Infection in Developing Countries 6: 352-357.20Castagnola E, Furfaro E, Caviglia I, et al. (2010) Performance of the galactomannan antigen detection test in the diagnosis of invasive aspergillosis in children with cancer or undergoing haemopoietic stem cell transplantation. Clinical Microbiology & Infection 16: 1197-1203.21Armenian SH, Nash KA, Kapoor N, et al. (2009) Prospective monitoring for invasive aspergillosis using galactomannan and polymerase chain reaction in high risk pediatric patients. Journal of Pediatric Hematology/Oncology 31: 920-926.22Steinbach WJ, Addison RM, McLaughlin L, et al. (2007) Prospective aspergillus galactomannan antigen testing in pediatric hematopoietic stem cell transplant recipients. Pediatric Infectious Disease Journal 26: 558-564.23Hayden R, Pounds S, Knapp K, et al. (2008) Galactomannan antigenemia in pediatric oncology patients with invasive aspergillosis. Pediatric Infectious Disease Journal 27: 815-819.24Hovi L, Saxen H, Saarinen-Pihkala UM, Vettenranta K, Meri T, Richardson M. (2007) Prevention and monitoring of invasive fungal infections in pediatric patients with cancer and hematologic disorders. Pediatric Blood & Cancer 48: 28-34.25El-Mahallawy HA, Shaker HH, Ali Helmy H, Mostafa T, Razak Abo-Sedah A. (2006) Evaluation of pan-fungal pcr assay and aspergillus antigen detection in the diagnosis of invasive fungal infections in high risk paediatric cancer patients. Medical Mycology 44: 733-739.26Bialek R, Moshous D, Casanova JL, Blanche S, Hennequin C. (2002) Aspergillus antigen and pcr assays in bone marrow transplanted children. European Journal of Medical Research 7: 177-180.27Rohrlich P, Sarfati J, Mariani P, et al. (1996) Prospective sandwich enzyme-linked immunosorbent assay for serum galactomannan: Early predictive value and clinical use in invasive aspergillosis. Pediatric Infectious Disease Journal 15: 232-237.28Dinand V, Anjan M, Oberoi JK, et al. (2016) Threshold of galactomannan antigenemia positivity for early diagnosis of invasive aspergillosis in neutropenic children. Journal of Microbiology, Immunology and Infection 49: 66-73.29Koltze A, Rath P, Schoning S, et al. (2015) Beta-d-glucan screening for detection of invasive fungal disease in children undergoing allogeneic hematopoietic stem cell transplantation. Journal of Clinical Microbiology 53: 2605-2610.30Fisher BT, Zaoutis TE, Park JR, et al. (2012) Galactomannan antigen testing for diagnosis of invasive aspergillosis in pediatric hematology patients. Journal of the Pediatric Infectious Diseases Society 1: 103-111.31Tabone MD, Vu-Thien H, Latge JP, et al. (1997) Value of galactomannan detection by sandwich enzyme-linked immunosorbent assay in the early diagnosis and follow-up of invasive aspergillosis. Opportunistic Pathogens 9: 7-13.32Zhao L, Tang JY, Wang Y, et al. (2009) [value of plasma beta-glucan in early diagnosis of invasive fungal infection in children]. Zhongguo Dang Dai Er Ke Za Zhi 11: 905-908.33Mandhaniya S, Iqbal S, Sharawat SK, Xess I, Bakhshi S. (2012) Diagnosis of invasive fungal infections using real-time pcr assay in paediatric acute leukaemia induction. Mycoses 55: 372-379.34Landlinger C, Preuner S, Baskova L, et al. (2010) Diagnosis of invasive fungal infections by a real-time panfungal pcr assay in immunocompromised pediatric patients. Leukemia 24: 2032-2038.35Hummel M, Spiess B, Roder J, et al. (2009) Detection of aspergillus DNA by a nested pcr assay is able to improve the diagnosis of invasive aspergillosis in paediatric patients. Journal of Medical Microbiology 58: 1291-1297.36Dendis M, Horvath R, Michalek J, et al. (2003) Pcr-rflp detection and species identification of fungal pathogens in patients with febrile neutropenia. Clinical Microbiology & Infection 9: 1191-1202.37Lin MT, Lu HC, Chen WL. (2001) Improving efficacy of antifungal therapy by polymerase chain reaction-based strategy among febrile patients with neutropenia and cancer. Clinical Infectious Diseases 33: 1621-1627.38Cesaro S, Stenghele C, Calore E, et al. (2008) Assessment of the lightcycler pcr assay for diagnosis of invasive aspergillosis in paediatric patients with onco-haematological diseases. Mycoses 51: 497-504.39Leeflang MM, Debets-Ossenkopp YJ, Wang J, et al. (2015) Galactomannan detection for invasive aspergillosis in immunocompromised patients. Cochrane Database Syst Rev 12: CD007394.40Karageorgopoulos DE, Vouloumanou EK, Ntziora F, Michalopoulos A, Rafailidis PI, Falagas ME. (2011) Beta-d-glucan assay for the diagnosis of invasive fungal infections: A meta-analysis. Clin Infect Dis 52: 750-770.41Cruciani M, Mengoli C, Loeffler J, et al. (2015) Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people. Cochrane Database Syst Rev 10: CD009551.42Sung L, Phillips R, Lehrnbecher T. (2011) Time for paediatric febrile neutropenia guidelines - children are not little adults. Eur J Cancer 47: 811-813.43Petraitiene R, Petraitis V, Bacher JD, Finkelman MA, Walsh TJ. (2015) Effects of host response and antifungal therapy on serum and bal levels of galactomannan and (1-->3)-beta-d-glucan in experimental invasive pulmonary aspergillosis. Med Mycol 53: 558-568.44Duarte RF, Sanchez-Ortega I, Cuesta I, et al. (2014) Serum galactomannan-based early detection of invasive aspergillosis in hematology patients receiving effective antimold prophylaxis. Clin Infect Dis 59: 1696-1702.45Reinwald M, Hummel M, Kovalevskaya E, et al. (2012) Therapy with antifungals decreases the diagnostic performance of pcr for diagnosing invasive aspergillosis in bronchoalveolar lavage samples of patients with haematological malignancies. J Antimicrob Chemother 67: 2260-2267. ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- our study addressed the cytotoxic effects of different
- title early mortality in hyperleukocytosis in patients
- natural cancer treatments
- alternative cancer therapies austin ozone
- roger mason young again
- by professor serge jurasunas m natural healing and cancer
- 20 abstracts of 6999 on beta glucans listed on pubmed
- winning the battle against cancer therapy side effects
Related searches
- early turn in lease deals
- title of book in essay
- early scientists in history
- early trade in on lease
- 2019 virus mortality in usa
- early signs of dementia in men
- title too long for graph in r
- early signs of lymphoma in women
- free early childhood training hours in ky
- early immigration in the 1800
- early parkinson s symptoms in women
- early literacy in young children