International Center for Chemical and Biological Sciences ...



CURRICULUM VITAE

Dr. Asmat Salim

Current Position: Professor

Present Address: Dr. Panjwani Center for Molecular Medicine & Drug Research,

International Center for Chemical and Biological Sciences,

University of Karachi, Karachi-75270, Pakistan

Tel: +92 21-99261671

E. Mail: asmat.salim@iccs.edu; asmatsalim@

Home Address: B-2 Gulshan-e-Saleem Housing Society, University of Karachi, Karachi- 75270

Home Phone #: + 92 21 34800208

ACADEMIC CAREER

B. Sc. (Hons) (Biochemistry) 1990

First Class First position

Department of Biochemistry, University of Karachi, Pakistan

M. Sc. (Biochemistry) 1991

First Class First position

Department of Biochemistry, University of Karachi, Pakistan

Ph.D. (Protein Chemistry) 2001

HEJ Research Institute of Chemistry, University of Karachi, Pakistan

Ph.D. Thesis: “Structural Studies on Human Crystallins”

Passed the following courses offered as the partial fulfillment of the Ph.D. program:

▪ Physical Methods of Isolation and Structure Elucidation

▪ Proteins

▪ Enzymology

▪ Strategies in Protein Sequencing

▪ Protein and Peptide Synthesis

M.Sc. Thesis (Neuropharmacology): "Effect of tryptophan load on stress-induced changes of brain serotonin in male rats".

PRESENT STATUS

Professor, Dr. Panjwani Center for Molecular Medicine and Drug Research. International Center for Chemical and Biological Sciences, University of Karachi

PROFESSIONAL POSITIONS

Professor (February 2019 – present)

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi.

Associate Professor (November 2013 – January 2019)

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi.

Assistant Professor (April 2007 – December 2013)

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi.

Senior Research Officer (April 2004 – March 2007)

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi.

Visiting Scientist (August 2005 – November 2005)

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio.

Research Fellow (August 2004 – July 2005)

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio.

Assistant Professor (October 2003 – April 2004)

Department of Biochemistry, Baqai Medical University, Karachi.

Exam Question Writer (February 2003 – January 2004)

Online Exam Question writer in the field of Biochemistry, Biology and Chemistry, DSK College, London.

Visiting Faculty (June 2003- July 2003, Summer Course on Bioinformatics)

FAST Institute of Computer Science, National University of Emerging Sciences, Karachi, Pakistan.

Postdoctoral Research Fellow (April 2002 – April 2003)

Bioinformatics and Protein Chemistry (3D structure prediction of proteins by computer based molecular modeling), Department of Biochemistry, University of Karachi

Teaching Assistant / Cooperative Teacher (August 1993-December 1994)

Department of Biochemistry, University of Karachi, Karachi, Pakistan

CURRENT RESEARCH ACTIVITIES

Projects and Funding Sources:

Completed:

As PI:

1. Funding Agency: Higher Education Commission

Project: Role of preconditioned and genetically modified mesenchymal stem cells in the regeneration of cardiac tissue

Period: 2 years

Budget approved: Rs.3,534,639/=

2. Funding Agency: Pakistan Science Foundation

Project: Preconditioning of the stem and progenitor cells to increase their cardiomyogenic potential

Period: 2 years

Budget approved: Rs.813,200/=

Current:

As PI

1. Funding Agency: Higher Education Commission

Project: Study to Enhance the Therapeutic Potential of Mesenchymal Stem Cells for Diabetic Wound Healing

Period: 3 years

Budget approved: 6,545,932/=

As Co-PI

2. Funding Agency: Ministry of Higher Education, Malaysia

Project: Effects of Nigella sativa and its Constituents on Memory and its Mechanisms:

Neurobehavioral, Neurohistological and Cell Biological Approaches

Period: 3 years

Budget approved: RM.154,000/=

3. Funding Agency: Higher Education Commission

Project: Three dimensional (3D) scaffolds improve differentiation and function of histone deacetylase inhibitors treated mesenchymal stem cell-derived hepatocytes

Period: 3 years

Budget approved: Rs. 3,285,000/=

4. Funding Agency: Higher Education Commission

Project: Role of Marrow Stromal Cells in Cardiac Angiogenesis

Period: 3 years

Budget approved: Rs. Rs. 3,76,5790/=

5. Funding Agency: Higher Education Commission

Project: Therapeutic Role of Mesenchymal Stem Cells in Demyelinating Diseases; Potential to trans-differentiate into Oligodendrocytes

Period: 3 years

Budget approved: Rs. 3,513,248/=

Ph.D. awarded

1. Uzma Jabeen (2011)

2. Kanwal Haneef (2012)

3. Nadia Naeem (2012)

4. Irfan Khan (2013)

5. M. Aleem Akhter (2013)

6. Anwar Ali (2013)

7. Nazia Ahmed (2014)

8. Hana’a Iqbal (2014)

9. Rakhshinda Habib (2014)

10. Sumreen Begum (2015)

11. Sana Eijaz (2015)

12. Muhammad Waseem (2016)

13. Shumaila Usman (2017)

M.Phil. awarded

1. Ramla Sana Khalid (2016)

2. Aneesa Gul (2016)

3. Rida-e-Maria Qazi (2017)

4. Tuba Mustafa (2017)

5. Tuba Shakil Malick (2018)

6. Gulzar Alam (2018)

LIST OF PUBLICATIONS

Total Impact factor*= 83.146; Citations = 486; h-index = 10

1. Jilani T, Khan I, Salim A, Bilwani F, Moiz B, Azam I, Iqbal MP. Role of Vitamin E in inhibiting apoptosis of human CD34+- derived erythroid progenitor cells (EPCs). Submitted to Plos One.

2. Khan R, Nisar U, Perveen H, Rizvi NS, Anjum S, Salim A, Raza, ML, Simjee SU. Inhibitory potential of AC-31B (essential oil from Allium cepa) on epileptogenesis and alterations in the function of bone marrow cells induced by long-term kindled seizures in mice. Submitted to Neurological Research.

3. Begum S, Atta-ur-Rahman, Salim A. Developmental and Pluripotent Genes in Rat Neonatal Kidney: Potential Targets for Renal Tissue Regeneration. Manuscript submitted to Turkish Jounal of Biology.

4. Jabeen U, Naeem N, Khan I, Salim A, Ahmed W. Expression Analysis of Oxidative Stress Induced Genes in Liver and Heart Tissues in Response to Doxorubicin. Accepted in Pakistan Journal of Zoology.

5. Khalid RS, Khan I, Zaidi MB, Naeem N, Haneef K, Qazi R-M, Habib R, Malick TS, Ali A, Salim A. IL-7 Over-expression Enhances Therapeutic Potential of Rat Bone Marrow Mesenchymal Stem Cells for Diabetic Wounds. Accepted in Wound Repair and Regeneration 27: 235-248. IF = 2.952.

6. Haneef K, Ali A, Khan I, Naeem N, Jamall S, Salim A (2018) Role of IL-7 in Fusion of Rat Bone Marrow Mesenchymal Stem Cells with Cardiomyocytes in vitro and Improvement of Cardiac Function in vivo. Cardiovascular Therapeutics. e12479. IF = 2.245.

7. Ahmed N, Khan I, Begum S, Salim A (2017) Effect of 2, 4-Dinitrophenol preconditioning on the expression levels of mesenchymal markers in neonatal cardiac progenitors. Hellenic Journal of Cardiology, 58: 98-102. IF = 1.890.

8. Khan I, Ali A, Akhter MA, Naeem N, Chotani MA, Iqbal H, Kabir N, Atiq M, Salim A (2017) Epac-Rap1-activated mesenchymal stem cells improve cardiac function in rat model of myocardial infarction. Cardiovascular Therapeutics, 35(2). IF = 2.245.

9. Usman S, Khan I, Naeem N, Iqbal H, Ali A, Usman S, Salim A (2016). Conditioned media trans-differentiate mature fibroblasts into pancreatic beta-like cells. Life Sciences, 164:52-59. IF = 3.234

10. Khan I, Ali A, Akhter MA, Naeem N, Chotani MA, Mustafa T, Salim A (2016) Preconditioning of mesenchymal stem cells with 2,4-dinitrophenol improved cardiac function in infarcted rats. Life Sciences, 162: 60-9. IF = 3.234

11. Waseem M, Khan I, Iqbal H, Eijaz S, Usman S, Ahmed N, Alam G, Salim A (2016) Hypoxic preconditioning improves the therapeutic potential of aging bone marrow mesenchymal stem cells in streptozotocin-induced type-1 diabetic mice. Cellular Reprogramming, 18: 12. IF = 1.430

12. Khanabdali R, Saadat A, Fazilah M, Bazli KFK, Qazi R-M, Khalid RS, Adli DSH, Moghadamtousi SZ, Naeem N, Khan I, Salim A, Shamsuddin SA, Mohan G (2016) Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow derived mesenchymal stem cells. Drug Design, Development and Therapy, 10: 81-91. IF = 2.935

13. Habib R, Begum S, Alam G, Ali A, Waseem M, Khan, I, Kabir N, Rahman A, Salim A (2015) Transcription profile of genes affected in response to pathological changes in drug induced rat model of acute kidney injury. Renal Failure, 37: 1225-31. IF = 1.440

14. Habib R, Haneef K, Naeem N, Khan I, Jamall S, Rahman A, Salim A (2015) Hypoxic stress and IL-7 gene over-expression enhance the fusion potential of rat bone marrow mesenchymal stem cells with bovine renal epithelial cells. Molecular and Cellular Biochemistry, 403:125-37. IF = 2.561

15. Ali A, Akhter MA, Haneef K, Khan I, Naeem N, Habib, R, Kabir N, Salim A (2015) Dinitrophenol modulates gene expression levels of angiogenic, cell survival and cardiomyogenic factors in bone marrow derived mesenchymal stem cells. Gene, 5: 448-57. IF = 2.498

16. Haneef K, Naeem N, Iqbal H, Khan I, Jamall S, Kabir N, Zahid M, Salim A (2014) Conditioned medium enhances the fusion capability of rat bone marrow mesenchymal stem cells and cardiomyocytes. Molecular Biology Reports, 41: 3099-112. IF = 1.889

17. Eijaz S, Salim A, Waqar MA (2014) Possible molecular targets of cinnamon in the insulin signaling pathway. Journal of Biochemical Technology, 5: 708-17.

18. Khan I, Ahmed N, Akhter MA, Ali A, Haneef K, Naeem N, Salim A (2013) Effect of Rap1 GTPase activation and hypoxia on the gene expression pattern of cell adhesion molecules in bone marrow derived Mesenchymal stem cells. Pak J Biochem Mol Biol, 46: 16-21.

19. Naeem N, Haneef K, Kabir N, Iqbal H, Jamall S, Salim A (2013) DNA demethylating agents, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Cardiovascular Therapeutics, 31: 201-9. IF = 2.245

20. Jabeen U, Salim A (2013) Sequence Analysis and Structure Prediction of Enoyl CoA Hydratase from Avicennia marina; Implication of Various Amino Acid Residues on Substrate-Enzyme Interactions. Phytochemistry, 94: 36-44. IF = 3.186

21. Razwi NZ, Khurshid R, Saleem M, Karim S, Nagra SA and Salim A (2012) Biochemical analysis of granzyme H and elucidation of its structurally important residues involved in substrate and inhibitor binding. J. Chin. Pharm. Sci., 21, 33-39.

22. Begum M, Karim S, Malik A, Khurshid R, Asif M, Salim A, Nagra SA, Zaheer A, Iqbal Z, Abuzenadah AM, Alqahtani MH, Rasool M (2012) CA 15-3 (Mucin-1) and physiological characteristics of breast cancer from Lahore. Asian Pac J Cancer Prev, 13: 5257-61. IF = 2.39

23. Jabeen U, Salim A, Abbasi A (2012) Prediction of Post Translational 

Modifications in Avicennia marina Cu-Zn Superoxide Dismutase: 

Implication of Glycation on the Enzyme Structure. J  Chem Soc Pak, 34, 404-14.

24. Jabeen U, Abbasi A, Salim A (2011) Predicting the functionally distinct residues in the heme, cation and substrate binding sites of peroxidase from stress-tolerant mangrove specie, Avicennia marina. Cell Stress and Chaperones, 16: 585-605. IF = 2.571

25. Jabeen U, Salim A, Abbasi A (2011) Prediction of enzyme-inhibitor interactions in Avicennia marina Cu-Zn Superoxide Dismutase: implications of functionally significant residues in the metal binding sites. Pak J Biochem Mol Biol, 44: 1-7.

26. Khurshid R, Saleem M, Akhtar MS, Salim A (2011) Granzyme M: characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors. Molecular Biology Reports, 38: 2953-60. IF = 1.889

27. Haneef K, Naeem N, Iqbal H, Jamall S, Kabir N, Salim A (2010) Gene expression pattern in rat bone marrow mesenchymal stem cells in response to hypoxia. Pak J Biochem Mol Biol 43: 90-3.

28. Gul A, Rahman MA, Salim A, Simjee SU (2009) Advanced glycation end products in senile diabetic and nondiabetic patients with cataract. J Diabetes Complications 23: 343-8. IF = 2.792

29. Hashim Z, Ilyas A, Saleem A, Salim A, Zarina S (2009) Expression and activity of Paraoxonase 1 (PON1) in human cataractous lens tissue. Free Radical Biol & Med, 46: 1089-95. IF = 6.020

30. Gul A, Rahman MA, Salim A, and Simjee SU (2008) Advanced glycation end products in senile diabetic and nondiabetic patients with cardiovascular complications. AGE 30, 303-9. IF = 2.90

31. Gul A, Rahman MA, Hasnain SN, Salim A, Simjee SU. (2008) Could oxidative stress associate with AGE-products in cataractogenesis? Current Eye Research 33: 669-75. IF = 2.120

32. Jiang S, Haider KH, Ahmed RP, Idris NM, Salim A, Ashraf M. (2008) Transcriptional profiling of young and old mesenchymal stem cells in response to oxygen deprivation and reparability of the infarcted myocardium. Journal of Molecular and Cellular Cardiology 44: 582-96. IF = 5.296

33. Jiang S, Haider KH, Idris NM, Salim A, Ashraf M. (2006) Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and Promotes Angiomyogenesis for Cardiac Repair. Circulation Research, 99: 776-84. IF = 15.211

34. Khurshid R, Salim A, Abbasi A (2005) Three-dimensional structure prediction of bovine AP lyase, BAP1: prediction of interaction with DNA and alterations as a result of Arg176-->Ala, Asp282-->Ala, and His308-->Asn mutations. Biochem and Biophys Res Commun, 316, 711-7. IF = 2.559

35. Rashid A, Khurshid R, Begum M, Raana G, Latif M, Salim A (2004) Modeling the mutational effects on calmodulin structure; prediction of alteration in the amino acid interactions. Biochem Biophys Res Commun 317: 363-9. IF = 2.559

36. Salim A, Zaidi ZH (2004) Prediction of stability factors at the domain interface of Human γB crystallin by Homology Modeling. J Pak Med Assoc, 54: 419-22.

37. Salim A, Bano A, Zaidi ZH (2003) Prediction of possible sites for post translational modifications in Human Gamma Crystallins: Effect of glycation on the structure of human gammaB-crystallins as analyzed by molecular modeling. Proteins Structure, Function and Genetics, 53: 162-73. IF = 2.274

38. Salim A, Haleem R, Murtaza F, Shameem G, Perveen T, Haleem DJ (2003) Injected tryptophan increases brain but not plasma tryptophan level more in stressed rats. Pak J Pharm Sciences, 16: 51-7. IF = 0.804

39. Salim A, Zaidi ZH. (2003) Homology models of human gamma crystallins: structural study of the extensive charge network in gamma crystallins. Biochem Biophys Res Commun, 300: 624-30. IF = 2.559

40. Khurshid R, Salim A (2000) Amino acid sequence homology and modelling of cystein protease cathepsin S. Pak J Biol Sci, 3, 639-41.

BOOK CHAPTER

Irfan Khan, Nadia Naeem, Anwar Ali and Asmat Salim (2017) Role of small molecules in the cardiac differentiation of mesenchymal stem cells; In Stem Cells - From Drug to Drug Discovery, Ed: Haider Khawaja Husnain, De Gruyter Publisher, Germany. DOI 10.1515/9783110493764-002

PRESENTATIONS/ABSTRACTS

• Asmat Salim. “Differentiation of Rat Bone Marrow Mesenchymal Stem Cells into Cardiomyocytes: Role of Small Molecules”. Invited Speaker at the “Molecular Biosciences: Research and Innovations”, Fourteenth Biennial Conference of Pakistan Society of Biochemistry and Molecular Biology (PSBMB), Dr. A. Q. Khan Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karachi, Pakistan (December 9 - 12, 2018).

• Asmat Salim. Stem Cell Research and its Applications. Invited Speaker at ZABCON’18, SZABIST Annual Biosciences Conference, SZABIST, Karachi, Pakistan (November 27 - 28, 2018).

• Asmat Salim, Kanwal Haneef, Anwar Ali, Irfan Khan, Nadia Naeem. IL-7 Increases Fusion of Rat Bone Marrow Mesenchymal Stem Cells with Cardiomyocytes in vitro and Improve Cardiac Function in vivo. Poster presented at the 14th Annual Basic Cardiovascular Sciences (BCVS) 2018 Scientific Sessions, San Antonio, TX, USA (July 30 – Aug 02, 2018).

• Asmat Salim, Irfan Khan, Nadia Naeem, Anwar Ali, Kanwal Haneef. Demethylating Agents and Cardiac Differentiation of Bone Marrow Mesenchymal Stem Cells. Invited Speaker at the 1st Probe Conference 2018, Department of Physiology, University of Karachi, Karachi, Pakistan (January 16 - 18, 2018).

• Asmat Salim, Irfan Khan, Anwar Ali, Kanwal Haneef, Nadia Naeem, M. Aleem Akhter. Regeneration of Cardiac Tissue by Mesenchymal Stem Cells Following Myocardial Infarction in Rats. Keynote Lecture presented at the Regional Conference on Materials & ASEAN Microscopy Conference 2017 (RCM & AMC 2017), Penang, Malaysia (December 12 - 13, 2017).

• Asmat Salim, Irfan Khan, Anwar Ali, Kanwal Haneef, Nadia Naeem, M. Aleem Akhter. Regeneration of Cardiac Tissue by Mesenchymal Stem Cells Following Myocardial Infarction in Rats. Keynote Lecture presented at the Regional Conference on Materials & ASEAN Microscopy Conference 2017 (RCM & AMC 2017), Penang, Malaysia (December 12 - 13, 2017).

• Asmat Salim, Rida-e-Maria Qazi, Kanwal Haneef, Irfan Khan, Nadia Naeem. Three Dimensional Collagen Scaffold Combined with Zebularine Treated Rat Bone Marrow Mesenchymal Stem Cells Improved Cardiac Differentiation in vitro. Poster presented at the Scientific Sessions 2017, Anaheim, CA, USA, November 11-15, 2017 (Supplemented to Circulation Vol. 136, November 14, 2017).

• Ramla Sana Khalid, Midhat Batool Zaidi, Irfan Khan, Nadia Naeem, Anwar Ali, Rakhshinda Habib, Kanwal Haneef, Asmat Salim. Enhanced Therapeutic Potential of Genetically Modified Rat Bone Marrow Mesenchymal Stem Cells for Diabetic Wounds. Paper presented at the 6th International Symposium-Cum-Training Course on Molecular Medicine and Drug Research, Karachi, Pakistan (November 6 - 9, 2017).

• Asmat Salim, Ramla Sana Khalid, Nadia Naeem, Anwar Ali, Midhat Batool, Irfan Khan. IL-7 Over-expression in Mesenchymal Stem Cells Enhances Regeneration of Diabetic Wounds. Poster presented at the ISSCR International Symposium, Basel, Switzerland (February 27 - March 1, 2017).

• Asmat Salim, Anwar Ali, M. Aleem Akhter, Irfan Khan, and Nadia Naeem. Combined Effect of Dinitrophenol Preconditioning and Jagged-1 Over-expression in Mesenchymal Stem Cells Improved Cardiomyogenesis and Angiogenesis in Rat Model of Myocardial Infarction. Poster presented at the 12th Annual Basic Cardiovascular Sciences (BCVS) 2016 Scientific Sessions, Phoenix, AZ, USA (July 18 – 21, 2016).

• Asmat Salim. Cardiac Regeneration by Cell Based Therapy. Paper presented at the 1st International Conference on Life Sciences" Emerging Trends in Biological Sciences and Genomics", Karachi, Pakistan (December 28-30, 2015).

• Asmat Salim, Kanwal Haneef, Anwar Ali, Muhammad Aleem Akhter, Irfan Khan, Nadia Naeem, Hana’a Iqbal, and Nurul Kabir. Preconditioning of Mesenchymal Stem Cells: Strategy for Enhancing the Regeneration of Ischemic Myocardium by Cell Based Therapy. Paper presented at the 4th Pak-France Bi-national Workshop on Drug Discovery and Molecular Medicine, Karachi, Pakistan (October 12-14, 2015).

• Nadia Naeem, Aneesa Gul, Anwar Ali, Irfan Khan, and Asmat Salim. Zebularine Enhances Cardiomyogenic Differentiation Potential of both Mesenchymal Stem Cells and Mature Fibroblasts. Poster presented at the Scientific Sessions 2014, Chicago, IL, USA, Nov. 15-19, 2014 (Supplemented to Circulation Vol. 130, No 22, November 25, 2014).

• Irfan Khan, Muhammad Aleem Akhter, Nadia Naeem, Anwar Ali, Hana’a Iqbal, and Asmat Salim. Rap1 activated mesenchymal stem cells transplantedin infarcted myocardium improve heart function. Poster presented at the“11th Biennial Conference of the Pakistan Society for Biochemistry and Molecular Biology (PSBMB)”, Lahore, Pakistan (November 25-28, 2013).

• Asmat Salim, Nadia Naeem, Kanwal Haneef, Anwar Ali, Muhammad Aleem Akhter, Irfan Khan, Hana’a Iqbal Nurul Kabir and Siddiqua Jamall. Chemical and Genetic Modification of Rat Mesenchymal Stem Cells Enhanced their Trans-differentiation Potential into Cardiomyocytes. Paper presented at the 4th International Symposium-Cum-Training Course on Molecular Medicine and Drug Research, Karachi, Pakistan (January 7-10, 2013).

• Kanwal Haneef, Nadia Naeem, Hana’a Iqbal, Nurul Kabir, Siddiqua Jamall, and Asmat Salim. In vitro fusion and differentiation of bone marrow mesenchymal stem cells into cardiomyocytes. Paper presented at the Symposium on Omics Research: Road Map for Future, Karachi, Pakistan (February 22, 2012).

• Asmat Salim, Kanwal Haneef, Nadia Naeem, Nazia Ahmed, Hana’a Iqbal, Siddiqua Jamall and Nurul Kabir. Preconditioned Bone Marrow Stem Cells and their Differentiation into Cardiomyocytes. Paper presented at the 3rd International Symposium-cum-training course on Molecular Medicine and Drug Research, Karachi, Pakistan (January 3-6, 2011).

• Asmat Salim, Kanwal Haneef, Nadia Naeem, Hana’a Iqbal, Nurul Kabir and Siddiqua Jamall. Transdifferentiation Potential of Normal and Modified Rat

Mesenchymal Stem Cells into Cardiomyocytes. Paper presented at the 3rd France-Pak bi-national Symposium, Besançon, France (July 15-18, 2010).

• Nadia Naeem, Kanwal Haneef, Siddiqua Jamall and Asmat Salim. Cardioprotective effect of 5-azacytidine and zebularine on bone marrow mesenchymal stem cells. 47th Annual Medical Symposium, Jinnah Postgraduate Medical Center, Karachi, Pakistan (February 15-21, 2010).

• Asmat Salim, Kanwal Haneef, Nadia Naeem, Hana’a Iqbal and Siddiqua Jamall. Transdifferentiation Potential of Normal and Engineered Rat

Mesenchymal Stem Cells into Cardiomyocytes. Paper presented at the 2nd International Symposium-cum-training course on Molecular Medicine and Drug Research, Karachi, Pakistan (January 12-15, 2009).

• Shabana U. Simjee, Asmat Salim and Raheela Khan. Suppression of Long-term Kindled Seizures Induced alterations in hematopoietic functions in Bone Marrow Cells by Essential Oil from Allium cepa. Poster presented at the 38th annual meeting of the Society for Neuroscience, Washington, DC, USA (November 15-19, 2008).

• Asmat Salim, Kh Husnain Haider, Shujia Jiang, Shahida Shujaat and Muhammad Ashraf. Transdifferentiation potential of young and aging bone marrow stem cells into cardiomyocytes. Workshop on Human Stem Cell: Principles and Applications jointly organized by COMSATS, Pakistan, UNESCO and National Research Center, Cairo Egypt (December, 26-27, 2007).

• Shujia Jiang, Husnain K Haider, Niagara Muhammad Idris, Rafeeq Ahmed, Asmat Salim and Muhammad Ashraf (2007). Transplantation of mesenchymal stem cells constitutively co-expressing Akt and Ang-1 leads to improved cardiac function in rodent model of acute myocardial infarction (Supplemented to Circulation Vol 116, No 16, October 16, 2007).

• Asmat Salim, Kh Husnain Haider, Shujia Jiang, Shahida Shujaat and Muhammad Ashraf. Transdifferentiation Potential of Young and Aging Bone Marrow Stem Cells into Cardiomyocytes. Paper presented at the 1st International Symposium-cum-training course on Molecular Medicine and Drug Research , Karachi, Pakistan (January 16-30, 2007).

• Husnain K Haidar, Shujia Jiang, Asmat Salim, Shahida Shujaat, Niagra M Idris, Ruowen Ge, Uemura Royta, Ashraf Muhammad. Transplantation of mesenchymal stem cells constitutively co-expressing Akt and Ang-1 leads to improved cardiac function in rodent model of acute myocardial infarction (Supplemented to Circulation Vol. 112, No 17, October 25, 2005).

• Yigang Wang, Husnain kh Haidar, Nauman Ahmad, Jeff Brown, Royta Uemura, Meifeng Xu, Sadia Sharif, Asmat Salim, Shahida Shujaat, Shujia Jiang, Ruowen Ge, Muhammad Ashraf. Combining pharmacological mobilization of bone marrow stem cells with intramyocardial injection of genetically modulated mesenchymal stem cells over expressing VEGF for cardiac repair (Supplemented to Circulation Vol 112, No 17, October 25, 2005).

• Asmat Salim and Zafar H. Zaidi. Prediction of stability factors at the domain interface of Human γB-crystallin by Homology Modeling. Paper presented at the 7th International Conference on Trends in Biochemistry and Molecular Biology organized by Pakistan Society for Biochemistry and Molecular Biology in April 2003, Lahore, Pakistan

• Asmat Salim and Zafar H. Zaidi. Prediction of structural changes in the two human γD-crystallin mutants caused by punctate, progressive juvenile-onset cataract and crystalline aculeiform or frosted cataract. Poster presented at the 7th International Symposium of Protein-Structure function relationship organized by HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

• Asifa Bano, Asmat Salim, Atiya Abbasi and Zafar H. Zaidi (2002). Comparison of three Classes ((, ( and () of Snake Neurotoxins by homology Modeling. Poster presented at the 7th Eurasia Conference on Chemical Sciences organized by HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

• Asmat Salim and Zafar H. Zaidi. Exploring the stability features of Human (-crystallin by homology modeling. Poster presented at the 7th Eurasia Conference on Chemical Sciences organized by HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

• Asmat Salim and Zafar H. Zaidi. Homology Modeling of human gamma crystallins. Poster presented at the 6th International Symposium of Protein-Structure function relationship organized by HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

• Asmat Salim, M. Kamran Azim and Zafar H. Zaidi. Homology Modeling of human alpha A crystallin. Paper presented at the National Chemistry Symposium, University of Karachi, Karachi, Pakistan.

• Sabira Naqvi, Asmat Salim and Zafar H. Zaidi. Poster presented on "Studies on water insoluble proteins from human cataractous lenses" at the National Symposium on Biochemistry and Molecular Biology, organized by the Biochemical Society of Pakistan, April 1995, Lahore, Pakistan.

• Asmat Salim, Riffat Haleem, Fouzia Murtaza, Ghazala Shameem, Tahira Perveen and Darakhshan J. Haleem. Injected tryptophan increases brain but not plasma tryptophan level more in stressed rats". Proceedings of the First International Conference of Pharmaceutical Sciences, Karachi, Pakistan.

HONOR(s) / AWARD(s)

• Paul Dudley White International Scholar; an award recognizes authors that contributed to the highest ranked abstract from each country among submitted abstracts, at the 14th Basic Cardiovascular Sciences (BCVS) scientific sessions, San Antonio, TX, USA (July 30 – Aug. 02, 2018).

• Travel grant awarded by Higher Education Commission, Pakistan to present poster at the 14th Basic Cardiovascular Sciences (BCVS) scientific sessions, San Antonio, TX, USA (July 30 – Aug. 02, 2018).

• Research Productivity Award from Pakistan Council for Scientific Research, 2016.

• Paul Dudley White International Scholar; an award recognizes authors that contributed to the highest ranked abstract from each country among submitted abstracts at the American Heart Association Scientific Sessions 2017, Anaheim, CA, USA (Nov. 11-15, 2017).

• Travel grant awarded by Higher Education Commission, Pakistan to present poster at the Scientific Sessions 2017, Anaheim, CA, USA (Nov. 11-15, 2017).

• Travel grant awarded by Higher Education Commission, Pakistan to present poster at the 12th Basic Cardiovascular Sciences (BCVS) meeting, Phoenix, AZ, USA (July 18-21, 2016).

• Research Productivity Awards from Pakistan Council for Scientific Research, 2014.

• Travel grant awarded by Higher Education Commission, Pakistan to present poster at the Scientific Sessions 2014, Chicago, IL, USA (Nov. 15-19, 2014).

• Research Productivity Award from Pakistan Council for Scientific Research 2013.

• Research Productivity Award from Pakistan Council for Scientific Research 2011.

• Research Productivity Award from Pakistan Council for Scientific Research 2005.

• Travel grant awarded by Higher Education Commission, Pakistan to present poster at the 38th annual meeting of the Society for Neuroscience in Washington, DC, USA (Nov. 15 to 19, 2008).

• Second Prize in poster competition at the 7th International Symposium on Protein Structure Function relationship organized by H.E.J. Research Institute of Chemistry, University of Karachi.

• Merit certificates awarded from University of Karachi in 1990 and 1991.

• Zaidi Abid Gold Medal for obtaining first class first position in M.Sc. in Biochemistry.

MEMBERSHIP OF SCIENTIFIC SOCIETIES

• American Heart Association (AHA)

• International Society for Stem Cell Research (ISSCR)

• Wound Healing Society (WHS)

PROFESSIONAL SKILLS

• Cell Biology: Cell culture, Microscopy (Confocal, Phase-Contrast and Fluorescent), Immuno-histochemistry, Flow Cytometry.

• Protein purification techniques like conventional and automated (HPLC) chromatography, Electrophoresis, Western Blotting, etc.

• Spectrophotometeric techniques like UV, Visible, etc.

• Molecular Biology: RT-PCR

MAJOR COURSES AND WORKSHOPS

• Workshop on Human Stem Cell: Principles and Applications (Dec, 26-27, 2007) jointly organized by COMSATS, Pakistan, UNESCO and National Research Center, Cairo Egypt.

• S* Online Bioinformatics Course (17 Feb to 2 June 2003) organized by The S* Life Science Informatics Alliance. The international course was run jointly by Karolinska Institutet, National, University of Singapore (NUS), Stanford University, University of Western Cape's South Africa National Bioinformatics Institute (SANBI), University of Sydney, Uppsala University, Sweden, and University of California San Diego.

• Series of International workshops on Protein Structure Function Relationship from 1993-1997 organized by the Protein Chemistry Section at the HEJ Research Institute of Chemistry, University of Karachi.

REFERENCES

Will be provided on request

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