DRAFT New CV JDWillett 11/14/02



Professor James D. Willett, PhD

CURRICULUM VITAE

JAMES D. WILLETT

George Mason University

School of Systems Biology

College of Sciences

10900 University Boulevard, MSN 5B3

Manassas, Virginia 20110-2203

(703) 993-8311

jwillett@gmu.edu



EDUCATION: A.B. (Chemistry), 1959

University of California, Berkeley

Ph.D. (Organic Chemistry), 1965

Massachusetts Institute of Technology

Postdoctoral (Bio-organic Chemistry), 1965-1968

Stanford University

EXPERIENCE:

Director, School of Systems Biology, College of Sciences, George Mason University, January 2011 to present

Chair, Molecular and Microbiology, College of Sciences, George Mason University, December 2006 to January 2011

Professor, Departments of Molecular and Microbiology, and Bioinformatics and Computational Biology, College of Sciences, George Mason University, 2004 to present

Director of Operations, Biomedical Genomics and Informatics and Assistant director of the Biodefense Center, College of Arts and Sciences, George Mason University, October 2001 - 2003

Professor of Biochemical Systematics, School of Computational Sciences and College of Arts and Sciences, George Mason University, January 2001 to 2006

Director, Molecular Biosciences and Informatics, School of Computational Sciences, George Mason University, March 2000 – October 2001.

Professor; Molecular Biosciences Institute, School of Computational Sciences, George Mason University, March 1997 – March 2000

Director Cooperative Academic Enterprise Board, July 1996 - February 1997

Interim Director Molecular Biosciences and Technology Institute, October 1995 - January 1997

Executive Director for Biosciences Development, January 1995 - June 1997

Acting Director of Computational Sciences and Informatics Institute (CSI), January 1993 - July 1994

Vice Provost for Research and Graduate Studies, George Mason University, Fairfax, Virginia, July 1992 - December 1994

Chairman, Biology Department, George Mason University, Fairfax, Virginia, July 1989 - July 1992

Chief, Office of Program Planning and Evaluation, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, May 1987 - June 1989

Chief, Biological Models and Material Resources Section, Animal Resources Program, National Center for Research Resources, National Institute of Health, Bethesda, Maryland, February 1985 - June 1989

Health Science Administrator, Biomedical Research Models Development, Animal Resources Program, Division of Research Resources, National Institutes of Health, Bethesda, Maryland, 1984-1985

Special Assistant to the Director, Division of Research Resources, National Institutes of Health, Bethesda, Maryland, 1982-1984

Staff Assistant to the Deputy Director, Division of Research Resources, National Institute of Health, Bethesda, Maryland, 1981-1982

Grants Associate, National Institute of Health, Bethesda, Maryland, 1980-1981

Professor of Chemistry and Biochemistry, University of Idaho, Moscow, Idaho, 1977-1980

Associate Professor of Chemistry and Biochemistry, University of Idaho, Moscow, Idaho, 1973-1977

Assistant Professor of Chemistry, University of Idaho, Moscow, Idaho, 1968-1973

Research Associate in Nematology, Institute of Clinical Pharmacology,

Berkeley, California, 1968 (April-July)

Postdoctoral Fellow in Chemistry, Stanford University, Palo Alto, California, 1965-1968

Junior Chemist in the Bioorganic Division, Merck, Sharp & Dohme Research Laboratories, Rahway, New Jersey, 1959-1961

CORPORATE RELATIONSHIPS

President: BioConcepts. Startup Company offering rapid toxicity assays employing the nematode Caenorhabditis elegans. 1979-1981

Research Consultant and stockholder in BioSyne corp. 1986-89. This Startup Company was developing methodologies for separation of X and Y bearing mammalian sperm, initially targeting the Dairy industry. A patent was issued in 1988 for the separations methodology I developed for this Company.

I served as a consultant and research collaborator with America Tomorrow Inc., 1997 - 1999. The company was involved in multimedia distance education product development. A web-based course in biochemistry was developed (). A paper describing this product was presented at the Association for the Advancement of Computing in Education International conference in Freiburg, Germany, June 20-25, 1998.

Research collaborator, Environmental Science Associates, Inc.: 1996 - 2007. Established studies designed to generate methodologies for rapid assessment of the mechanisms of actions of neurotoxins utilizing the nematode Caenorhabditis elegans as a reporter system.

I served as a member of the Board of Directors of PACEL Corp; a software development company. Products included; Visual Writer, Child Watch, Zoomer and other software products. 1998- 2000.

ECONOMIC DEVELOPMENT

As Executive Director of Biosciences Development for George Mason University, I led the University’s successful effort, begun in 1990, to bring the American Type Culture Collection to Prince William County. The County’s Department of Economic Development, considered Biotech firms as prime targets for enhancing the region’s economic potential. The establishment of a “Cooperative Academic Enterprise” served as an attractant to biotechnology based firms. A paper, Universities: Partners in Economic Development, describing this activity was presented at the Society for College and University Planning’s International Conference, SCUP-33, in Vancouver BC, July 18-22, 1998. I continued to aid the County’s economic development efforts in this area, and served on a committee exploring the Region’s need for a Bioscience Incubator. I had a significant role in initiating the acquisition and design of two of the buildings now serving to house the research laboratories on George Mason Universities Prince William campus.

FORMAL TRAINING: Hours

Advanced Project Officers Training Course (DHHS), 1985 24

Seminar for New Managers, Executive Seminar Center, (OPM), 1984 80

The New Federalism (OPM), 1983 24

Civil rights Contract Compliance for Project Officers (NIH), 1983 8

Executive Seminar Series (PHS), 1982

Management Perspectives for the Future 2

Strategic Management 16

Capitol Hill Workshop (OMP), 1982 40

Hearings Process Workshop, 1982 24

Project Officers Training Course (DHHS), 1980 32

Grants Associates Seminar Series (NIH), 1980-1981 160

Division of Research Grants Incidents Course (NIH), 1981 8

American Association for the Advancement of Science 5th Annual

Colloquium on R&D Policy, 1981 16

Advanced Management Seminar (OPM), 1980 40

Survey of Modern Management Concepts (NIH), 1980 48

Legislative Operations Roundtable for Executives (OPM), 1980 40

The Federal Budget Process (NIH), 1980 24

TECHNICAL COURSES:

“In-Vitro Toxicology- Approaches to Validation” 16

John Hopkins School of Medicine, 1986

Introduction to FORTRAN IV (DCRT), 1983 30

Introduction to Programming and Program Logic (DCRT), 1983 3

Introduction to Computers (DCRT), 1982 6

Introduction to WYLBUR for Data Processing Applications

(DCRT), 1982 18

“Acute Toxicity Testing - Alternative Approaches”

Johns Hopkins School of Medicine, 1983 16

SYSTEMS, SOFTWARE, APPLICATIONS PROGRAMS:

Hardware: DEC-10; IBM-370; DEC-PC, IBM-PCS, SUN & Silicone Graphics work stations

Software: Operating Systems: CP/M, MS/dos, UNIX, Windows, OS/2

WYLBUR, Lotus, Multiplan, Select-86, dBase-II, Poly Com, IRX, DW3, WordPerfect, ChemDraw 4, ChemOffice, ChemFinder, PowerArray.

ORGANIZATION MEMBERSHIPS:

American Chemical Society

American Association for the Advancement of Science

Sigma Xi

ACS-Washington-Metropolitan Section

American Institute of Chemists

American Association of Individual Investors

New York Academy of Sciences

SPECIAL AWARDS:

NIH/DRR Merit Award, June 1987

DHHS/PHS/NIH Special Achievement Award, August 23, 1985

Phi Kappa Phi

NIH Career Development Award, 1975-1980 (University of Idaho)

Faculty Research Fellowship, summer 1969 (University of Idaho)

NIH Postdoctoral Fellowship, 1965-1968 (Stanford University)

NIH Postdoctoral Fellowship, 1964-1965 (MIT)

Schering Corp. -E.B. Hershberg Predoctoral Fellowship, 1963-1964 (MIT)

Chicle, Predoctoral Fellowship, 1962-1963 (MIT)

Kooper’s Predoctoral Fellowship, summer 1962 (MIT)

INVITED LECTURES AND SPEAKING ENGAGEMENTS:

Johns Hopkins University; Invited lecture; Electronic Coaching and Instruction on the Internet, Course # 893.645 February 10, 1998

Standard & Poor - The Cooperative Academic Enterprise, June 23, 1996

Sigma Xi - Development of a Cooperative Academic Enterprise: ATCC & GMU, March 27, 1996

Presentation to “Exploratory Committee of the Center for Innovative Technologies” - topic -The GMU Biosciences Program at Manassas, May 19, 1995

Presentation: GMU’s Efforts in the Biosciences - The German American Business Association, May 3, 1995

SAIC Science Policy Forum meeting with Czech and Slovak Scientists - Environmental Risk Assessment, June 22, 1994

National Academy of Sciences - NAS NAE IOM – “Convocation on Scientific Conduct”, June 6-7, 1994

Applied Information Management Institute team meeting - SITE/GMU, November 11, 1992

Department of Microbiology and Immunology - George Washington University, October 12, 1992

Writing in Science Panel - GMU English Department, September 25, 1992

Presentation at Symposium – “Politics & Creativity in America - The Politics of Funding in Health Science”: fetal tissue issues, October 7, 1991

“Alternatives to Animals for Biomedical Research and Testing,” Walter Reed Army Institute of Research, Washington D.C., April 20, 1988

“Cell and Tissue Task Force” Juvenile Diabetes Foundation International, Philadelphia, Pennsylvania, April 11-12, 1988

“Biotechnology - Biomedical and Animal Resources”, Second World Conference on Diabetes Research, Monte Carlo, Monaco, March 6-9, 1988

“Alternatives to Animals in Research”, National Meeting of the American Society of Zoologists, New Orleans, Louisiana, December 27-28, 1987

“Culture Collection’s Role in Biotechnology”, Meeting of the Industrial Microbiological Society, Baltimore, Maryland, August 14, 1987

STEP Module, Hidden Data Bases at the NIH - January, 1987

Workshop on “Alternative Approaches to Toxicity Testing: Utilization of Nonmammalian Organisms”, Battelle’s Columbus Division, Columbus, Ohio, November 11-13, 1986

International Symposium on “The Future of Academic Libraries”, University of Ulm, West Germany, November 17-21, 1985

National Meeting of the Society of Animal Welfare Administrators, Atlanta, Georgia, October 1, 1985

STEP Module, Adjuncts to Animals in Research and Testing - April 30, 1985 - NIH American Physiological Society Symposium on Animals and Adjuncts in Research, FASEB, April 24, 1985

STEP Module II: Computers: Their Use in Extramural Programs--Accessing computer systems in other agencies, January 1984

National Capital Area Branch, American Association for Laboratory Animal Science. “Use of Microorganisms as Alternatives to Laboratory Animals,” September 15-16, 1983

NIGMS-sponsored Workshop for Intramural Postdoctoral Fellows on Extramural Programs and Grant Support-National Institutes of Health, May 3, 1983

STEP Module 1: Introduction to Extramural Programs, December 1982

“Trends in the Use of Animals in Research”, 16th Annual Meeting of the Society of Research Administrators, Atlanta, Georgia, September 1982

Biochemistry, WAMI Decentralized Medical Education Program, Washington State University and University of Idaho, November 1980 and 1981

University of Massachusetts, Laboratory for Experimental Biology, May 15-17, 1979

University of Oregon Health Sciences Center, April 25, 1979

Portland State University, April 26, 1979

Michigan Technical University, March 1979

Finnegan Institute, Cincinnati, Ohio, 1987

University of Massachusetts, Laboratory of Experimental Biology, 1978

University of California, Riverside, Department of Nematology, 1978

University of California, Riverside, Department of Nematology, 1977

OTHER PROFESSIONAL ACTIVITIES:

Workshops and Reports Developed and Delivered:

Forging Strategic Alliances for Technology Transfer 5/4/94 - I organized and ran this conference while serving as the Director of GMU’s Computational Science and Informatics Institute. Co-sponsors, The Center for Innovative Technology (CIT), the Center for Professional Development (CPD), George Mason University (GMU), INTEL, Grumman Data Systems & RCI, Ltd.

Communist Aspirations and Environmental Contamination: A Soviet Tragedy March 14 &16, 1994. A series of lectures by Alexey Yablikov the science advisor to Boris Yeltsin. Organized and ran this conference while serving as Vice Provost for Research as a means of enhancing GMU’s visibility in the Environmental Biosciences.

Research Grants Workshops - Presenting Public/Private Funding Opportunities to GMU’s faculty 12/3/93

Congressional Testimony:

Prepared Testimony and Testified before the Subcommittee on Science, Research and Technology of the House of Representatives Committee on Science and Technology on "Alternatives to Animal Use in Research and Testing", May 6, 1986

National Meetings:

Chaired Session on the "Assessment of Human Tissues and Organs in Research in Various disease Categories" at the Second National Conference on the Uses of Human Tissues in Research, Bethesda, Maryland, April 30, 1986

Participant;, The Winter Gordon Research Conference on "The Biology of Aging," Santa Barbara, California, January 22-26, 1979

NIH Bioinformatics Studies in which I served as Participant and/or Project Officer:

Models for Biomedical Research: A New Perspective. National Academy of Sciences Press 1985, ISBN 0-309-03538-4

Matrix Feasibility Workshops; Aug. 1986 in conjunction with the first “Macromolecules, Genes, and Machines International Symposium White Mountain Conference Center, Waterville Valley N.H. Aug.12-17, 1986

Report of the Matrix of Biological Knowledge Workshop conducted at the Santa Fe Institute. Oct. 1987. I served as faculty member and participant in examining “Framework Issues” and “Function Extracted from Peptide Abstracts” problems.

Reviews:

Papers for the Journal Complexity, October 5, 1995

Army Breast Cancer Research Program, January 24-26, 1994

American Institute of Biological Sciences Reviewer

The American Aging Association Journal papers, AGE

Journal of Proteome Research

Economic Development Activities:

I prepared the Cooperative Academic Enterprise Proposal that served as the Governor of Virginia’s Bid to relocate ATCC to Northern Virginia.

Prince William Campus Building Design

Building 1 - laboratory

Building 2 - all

Chi Associates Cooperative Agreement

Medical Sciences Research Institute (MSRI) Memorandum of Understanding and Agreement

ABS Memorandum of understanding and cooperative agreement

COMMITTEES AND OFFICES HELD:

Member, faculty Senate: Gen Ed committee: Policies and Procedures committee

Member, GMU/Medical Sciences Research Institute, Affiliation Team

Chair, Senior Technical Advisory Research Team (START)

Board of Trustees, SURA, Southeastern Universities Research Association, January 1991 - January 1996

Council Member, Oak Ridge Associated Universities, 1994-1995

Member, University Life Task Force, 1990 - 1993

Member, NIH AIDS Database Committee, 1987-1989

Member, NLM Biotechnology Database Committee, 1985-1989

DRR Representative to the NIH, Biotechnology Committee, 1985-1989

NIH Liaison, Science Group, Office of Policy Planning and Evaluation, EPA, 1984-1986

Member NIH Program Officer/Project Officer Forum, 1985-1989

Chairman, Division of Research Resources EEO Committee, 1984-1987

Co-chairman, Biological Chemistry Session, Northwest Regional ACS Meeting, 1978

Member, University of Idaho, Radiation Safety Committee, 1971-1974, 1977-1980

Program Director, University of Idaho, Biomedical Research Support Grant, 1977-1980

Course Chairman for Biochemistry in the WAMI Decentralized Medical Education Program, 1973-1980

Chairman, Interdisciplinary Studies Program, College of Letters and Science, University of Idaho, 1971-1974

President, Washington-Idaho Border Section, ACS, 1976

Secretary, Washington-Idaho Border Section, ACS, 1975

Treasurer, Washington-Idaho Border Section, ACS, 1974

Treasurer, University of Idaho Chapter, AFT, 1974, 1976-1977

Vice-Chairman: Chemistry-Physics Section, Northwest Scientific Association, 1973

Member: University of Idaho, Ad-Hoc Committee to Study Potential Undergraduate and Graduate Curriculum in Environmental Sciences, 1970; University of Idaho, Campus Affairs Subcommittee on Drugs, 1969-1971

Borah Foundation Committee, University of Idaho, 1969-1971

COURSES TAUGHT:

University of Idaho

Chem. 584 - Special topics: Nematode Biochemistry

Biochemistry 514-524 - Molecular and Cellular Biology: Biochemistry for Medical Students

Chem. 499 - Undergraduate Research

Chem. 501 - Chemistry Seminar

Chem. 583 - Graduate course, Nucleic Acids

Chem. 582 - Graduate course, Amino Acids and Proteins

Chem. 581 - Graduate course, Carbohydrates & Lipids

Chem. 483-484 - Biochemistry Laboratory

Chem. 481-482 - One year sequence in biochemistry

Chem. 480 - Introductory Biochemistry, one semester terminal course

George Mason University

PuAd. 727 - Risk Assessment

Biol. 694/PuAd 827 - Environmental Risk Assessment & Decision Making

Biol. 694/PuAd 825 - Risk Assessment & Risk Management

Biol. 991 - Applications of Biotechnology in the Environmental Sciences

Biol. 303 - Animal Biology - Laboratory

Biol. 991 - Graduate Seminar Course in Risk Management

Chem. 663/664 - Biochemistry Core Course, (3 credits) one year sequence for graduate students

Biol. 552/Chem 502 - Survey of Biochemistry

BINF/BIOS 701-Biochemical Systematics

Biol. 463/435-Mechanisms of Aging

BIOS 697-Cell Signaling

STUDENTS ADVISED:

University of Idaho: 1968-1980

Fifteen graduate students and three postdoctoral fellows

George Mason University: 1989-2010

* Paul Knechtges - completed PhD

A Knowledge-based System for Assessing Occupational Exposures

* Carol Bason - completed MS

Environmental Estrogens: Exposures and Responses

* Tim Standish - completed PhD

Random Amplified Polymorphic DNA as a Tool for Strain Identification and Systematic Analysis of the Nematode Genus Caenorhabditis

* Kevin Garahan - completed PhD

An Investigation of the Factors Affecting Community Response to Toxic Waste Cleanup

* Steve Hearne - completed PhD

Environmental Risk Assessment

* Chun Hong - completed PhD

Changes in Serotonin and Dopamine Across the Life Span of Aplasia California

* Gita Sudama - completed MS

Age Related Changes in Metabolites of Tryptophan and Tyrosine in Caenorhabditis Elegans

* Dan Lazenby - completed PhD

Environmental & Health Indicators: A New Role for the Animal Disposition Reporting System

◦ Ron Taylor - completed, PhD

A Graphics-oriented Computational Tool for Inference of Metabolic Pathways: PATHINFER

◦ Harry Erwin - completed, PhD

Biologically-realistic Neural Algorithms for Scene Reconstruction in a Heterogeneous 99Environment Using Biosonar Data

◦ Sheri Alpert - completed PhD

Policy Ethics & Computational Genomics

* Richard Troast- completed PhD

Nematodes as Biomarkers for Environmental Lead

* Sheila Dohls- MS

Tryptophan metabolism and Calcium Channel Blockers in

Caenorhabditis elegans

* Gita Sudama, PhD completed December 2008, BCB

There are observable metabolic signature patterns in C. elegans: Specifically for different life stages grown with and without the added antioxidants vitamin C and vitamin E

◦ Aristide Chikando; PhD completed September 2008, BCB

A computational study of excitation-contraction coupling: Mechanisms of sarcoplasmic reticulum calcium leak and the role of mitochondria in myoplasmic calcium regulation

◦ Ryosuke Kadoi; PhD completed, September 2008, BCB

Calcineurin-NFAT signaling network: Microarray meta-analysis on mouse genome

◦ Christy Tedrow; PhD completed, Biodefense 2009, MMB

Using remote sensing, ecological niche modeling, and Geographic Information Systems for Rift Valley fever risk assessment in the United States

◦ Mahadevan, Pad, PhD completed 2009, BCB

Data mining human adenovirus genomes using comparative genomics and bioinformatics approaches

◦ Luo, Yong, PhD completed 2009, BCB

Computational geometry approach to the analysis of organism-dependent features in protein structures

◦ Barb, Jennifer, PhD completed 2009, BCB

Elucidating splice variant genes using the Affymetrix exon array: Effective probeset filters are essential

◦ Porter, Mark, PhD completed 2007, BCB

◦ Thompson, Kevin, PhD completed 2008, BCB

An adenocarcinoma case study of the BaFL protocol: Biological probe filtering for robust microarray analysis

◦ Kory R. Johnson, PhD completed 2007, BCB.

Genomic profiling of blood for stroke diagnosis

◦ Bill Zhan, PhD completed 2007, BCB

Computational mutagenesis models for protein activity and stability analysis

◦ Shelley Jorgensen, PhD. completed 2008, CBDI.

Pro-thrombotic effects during anthrax pathogenesis

◦ Ru Sun, PhD completed 2008, Statistics, Dan Carr

Two-dimensional and three-dimensional layouts to aid human cognition of local structure in multivariate data

◦ Ganiraju Manyam, PhD completed 2009, MMB

Global patterns of changes in the gene expression associated with genesis of cancer

◦ Lance Bachelor, MS. completed 2009, MMB

◦ Ramakrishna Meduri, PhD completed 2009, BCB

◦ Walsh, Michael, PhD completed 2010, BCB

◦ Addepalli, Kanaka, PhD in process, BCB

◦ Andy VonCanon, PhD completed 2010, BCB

◦ Dave Millis, PhD in process, BCB

◦ Mike Garvey PhD in process, CBD

◦ Yvette Connell-Albert, PhD in process, MMB

* John Kopecky, PhD in process, BCB

* Neeraja Podugu, PhD completed 2010, MMB

* Chaired Committee

◦ Served on Committee

INSTRUMENTATION RESPONSIBILITIES

University of Idaho

Operation and maintenance of the Finnigan Model 1015C and Hitachi

Model RMU-6E mass spectrometers and maintenance of the radioisotope counting equipment

George Mason University

ESA, CoulArray HPLC Coulometric electrochemical analysis

COMMUNITY ACTIVITIES:

Potomac Peddlers

Potomac Appalachian Trail Club

Moscow Road Runners

PATENTS:

Country Number Date

United States 4,722,887 February 2, 1988

United States 4,032,551 June 28, 1977

United States 3,956,485 May 11, 1976

Great Britain 1,457,098 February 14, 1975

West Germany 2,506,271 February 14, 1975

France 75 04800 February 17, 1975

Italy 20,310 A February 14, 1975

Japan 19373 February 15, 1975

GRANT PROPOSALS APPROVED:

External

Maximizing Funding Potential: The Center for Biodefense; CIT Award BIO-02-007. $100,000, March 2002-Feb. 2004

Metabolic Profiling of Macrophage Tryptophan Metabolism; DARPA subcontract with Advanced Biosystems. $200,000. July 2002 – March 2003

Physiologic State Modifiers, Advanced Biosystems; Hadron Inc $80,000. July 2000 - Dec. 2001.

Biomedical Research Support Grant to NIH, December 31, 1978; $20,000; funded.

National Institutes of Health, National Institute on Aging, Hormones and Aging in Nematodes, July 1979-June 1984, for $782,416; approved but not funded.

Biomedical Research Support Grant to NIH, April 1977-1978, for $16,500; funded.

National Institutes of Health, National Institute on Aging, Grant #ROI-AGO0293,

Hormones, and Aging in Nematodes, July 1976-1979, for $156,446; funded.

Career Development Award, #5-KO4-AG000111, National Institute on Aging, Hormones and Hormonal Systems in Nematodes, May 1975-1980, for $120,000; funded.

Max C. Fleischmann Foundation for partial support of the purchase of a gas chromatograph/mass spectrometer/computer system, January 1972, for $41,665; funded.

Beet Sugar Development Foundation, Salary Support in Hatching Factor Studies, July 1974, for $1,500; funded.

Herman Frasch Foundation; Nematode Control Agents, July 1972 - June 1977, for $50,999;funded.

State of Idaho Office of Higher Education., the Relation of Field Infestations of the Sugar Beet Cyst Nematode to Concentrations of Trace Metals in the Soil, J.D. Willett and R.A. Porter, July 1, 1971, for $20,818; funded.

State of Idaho Office of Higher Education, the Relation of Field Infestations of the Sugar Beet Cyst Nematode to Concentrations of trace Metals in the Soil, J.D. Willett and R.A. Porter, July 1, 1971, for $20,818; funded.

NSF - Instructional Scientific Equipment Program; Biochemistry. Laboratory Program, January 15, 1970, for $6,760; approved but not funded.

NSF - Instructional Scientific Equipment Program; Biochemistry Laboratory Program, January 21, 1969, for $6,800; approved but not funded.

Internal

A Proposal for Research on the Relation Between the Enzyme, Diamine Oxidase and Cell Proliferation. To Research Council, M.D. Kluetz and J.D. Willett, July 1, 1978, for $5,600; funded.

State Agricultural Experiment Station Project. Non-Toxic Control Agents for Plant Parasitic Nematodes of the Genus Heterodera; J.D.Willett, funded.

1/76-12/76 $3,500

1/77-12/77 $2,000

1/78-12/78 $1,000

1/79-12/79 $1,500

1/80-12/80 $1,500

A Proposal for Research on Chemical Ionization Mass Spectrometry: To Research Council, J.D. Willett and J.M. Shreeve, July 1, 1974, for $24,000; funded for $14,000.

Hatching Factor of the Sugar Beet Cyst Nematode, Heterodera schachtii, State Funds for applied research, July 1972-1973, for $7,300; funded.

Hatching Factor of the Sugar Beet Cyst Nematode, Heterodera schachtii, State Funds for applied research, July 1971-1972, for $3,500; funded.

Hatching Factor of the Sugar Beet Cyst Nematode, Heterodera schachtii, State Funds for applied research, July 1970-1971, for $5,200; funded.

Non-Polar Fluorescent Probes, University of Idaho Research Foundation, 1969-1970, for $1,300; funded.

Nematode Sterols, University of Idaho Research Foundation, 1968/1969, for $1,400; funded.

Other

To NSF, Instrument Proposal, Fourier Transform NMR Facility (joint proposal with WSU), $138,000;

funded.

To NSF, Departmental Equipment Proposal: UV--visible Spectrophotometer, $35,000; funded.

To NSF, Undergraduate Research Participation Program: $15,000; funded.

To NIH, Biomedical Research Support Proposal, December 1976 for $20.000; funded.

PUBLICATIONS:

Cragoe, E.J., Jr., C.M. Robb, J.D.Willett, and J. Cason. 1960. 3-Hydroxy qulnoline. Organic Synthesis 40:54

Shen, T.Y., T.B. Windholz, A. Rosegay, B.E. Witzel, A.N. Wilson, J.D. Willett, W.J. Holtz, R.L. Ellis, A.R. Matzuk, S. Lucas, C.H. Stammer, F.W. Holly, L.H. Sarett, E.A. Risley, G.W. Nuss, and C.A. Winter. 1963. Non-steroid anti-inflammatory agents. Journal of American Chemistry Society. 85:44R.

van Tamelen, E.E., J.D. Willett, R.B. Clayton, and K.E. Lord. 1966. Enzymic conversion of squalene-2, 3-oxide to lanosterol and cholesterol. Journal of American Chemistry Society. 88:4752.

van Tamelen, E.E., J.D. Willett, M.A. Schwartz, and R. Nadeau. 1966. Non-enzymic laboratory cyclization of squalene-2,3-oxide. Journal of American Chemistry Society. 88:5937.

van Tamelen, E.E., K.B. Sharpless, J.D. Willett, R.B. Clayton, and A.L.Burlingame. 1967. Biological activities of some terminally modified squalene and squalene-2,3-oxide. Journal of American Chemistry Society. 89:3920

Willett, J.D., K.B. Sharpless, E.E. van Tamelen, and R.B. Clayton. 1967. Squalene2,3-oxide: an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. Journal Biological Chemistry. 242:4182

van Tamelen, E.E., J.D. Willett, and R.B. Clayton. 1967. On the mechanism of lanosterol biosynthesis from squalene-2,3-oxide. Journal of American Chemistry Society. 89:3371

Godtfredsen, W.O., H. Lorck, E.E. van Tamelen, J.D. Willett, and R.B. Clayton. 1968. Biosynthesis of fusidic acid from squalene-2, 3Oxide. Journal of American Chemistry Society. 90:208

Willett, J.D., J.R. Grunwell, and G. Berchtold. 1968. The photochemistry of cyclic dithioketals. Journal of Organic Chemistry. 33:2297

Lower, W.R., J.D. Willett, and E.L. Hanson. 1970. Selection for adaptation to increased temperatures in free-living nematodes. II. Some lipid differences in Pangrellus redivivus. Comparative Biochemistry & Physiology. 34:473.

Grunwell, J.R. and J.D. Willett. 1971. Novel reduction of 4,5 tetramethylene-l, 2-dithiole-2-thione. International Journal of Sulfur Chemistry. 1, Part A, 60.

Willett, J.D. and P. McMakin. 1972. "Trace Metals and Nematodes in Sugar Beets," Annual Report of the Idaho Nuclear Energy Commission. Report #6, pp. 30-33.

Willett, J.D. and W.L. Downey. 1973. Isolation and identification of lanosterol as a normal constituent of the lipids of the free-living nematode, Pangrellus redivivus. Comparative Biochemistry & Physiology. 46B:139

Willett, J.D. and P. McMakin. 1973. "Trace Metals and Nematodes in Sugar Beets," Annual Report of the Idaho Nuclear Energy Commission. Report #7, p. 25

Willett, J. D. and W. L. Downey, 1974 . Sterol biosynthesis in the free living nematode, Pangrellus redivivus. Biochemistry Journal. 138:233

Willett, J.D. and P. Knight (McMakin). 1974. "Trace Metals and Nematodes in Sugar Beets," Annual Report to the Idaho Nuclear Energy Commission. Report #8, p. 38

Willett, J.D. and P. Knight. 1976. "Quantitative Determination of Several Metallic Elements in Whole Cysts of Heterodera schachtii by Neutron Activation Analysis," Nematologica. 22, 352-359

Hammond, A.C., J.R. Carlson, and J.D. Willett. 1977. "The Isolation and Characterization of 3-Methylindole Metabolites in Goat Urine," Federation Proceedings. 36, 1116.

Willett, J.D. and L. Rahim. 1978. "Determination of adenosine 3', 5'-cyclic monophosphate levels in tissues of the free-living nematode, Panagrellus redivivus," Comparative Biochemistry & Physiology. 60B: 403-405

Bollinger, J.A. and J.D. Willett, 1978. "A method for age synchrony of Panagrellus redivivus in xenic culture," Nematologica. 24: 398-403

Willett, J.D. and I. Rahim. 1978. "Determination of guanosine 3',5 ' - cyclic monophosphate in tissues of the free-living nematode, Panagrellus redivivus,"Comparative Biochemistry & Physiology. 61B: 243-246

Willett, J.D., I. Rahim, and J.A. Bollinger. 1978. "Alterations in cyclic nucleotide levels with age in the free-living nematode, Panagrellus redivivus,” Age. 1, 78.

Willett, J.D., I. Rahim, and J.A. Bollinger. 1978. "Variations in prostaglandin (PGF2) levels with age in the nematode Panagrellus redivivus," Age. 1. 76

Willett, J.D., I Rahim, and J.A. Bollinger. 1978. "Cyclic Nucleotide Levels in Tissues of the Free-Living Nematode Panagrellus redivivus and their variation with age," Federation Proceedings. 37, 1537

Willett, J.D., W. Shimoda, M.T. Lin, V.L. Estergreen, and G.E. Moss. 1978. In Vivo Metabolites of (14C) Progesterone in Bovine Muscle and Adipose Tissue. Steroids. 32: 547-561.

Willett, J.D., and J.A. Bollinger. 1978. "Age Dependent Variations in Tissue Levels of ATP in the Nematode Panagrellus redivivus," Age. 1, 158

Willett, J.D., I. Rahim, M. Geist, and B.M. Zuckerman. 1980. "Cyclic Nucleotide exudation by nematodes and the effects on nematode growth, development and longevity," Age. 3, 82-87.

Willett, J.D. 1980. "Control Mechanisms in Nematodes" in Nematodes as Biological Models, B.M. Zuckerman, Editor. Academic Press. p. 179-225.

Willett, J.D. and M.M. Knight. 1982. "Determination of Chromium in Orchard Leaves by Reversed-Phase High-Performance Liquid Chromatography," Journal of Chromatography. 237:99-105

Willett, J.D., E.P. Brody, and M.M. Knight. 1982. "The Analysis of Fatty Alcohols and Fatty Acids As p-(Methylthio)-benzoate Esters," Journal of American Oil Chemists Society. 59:273-277

Findeis, P.M., C.J. Barinaga, J.D. Willett and S.O. Farwell. 1983. "Age-Synchronous Culture of Caenorhabditis Elegans: Technique and Applications," Experimental Gerontology. 1B: 263-275

Gay, W.I., and J.D. Willett. 1984. "The Spectrum of Biological Systems and the Selection of Models," National Symposium on Imperatives in Animal Use, Scientific Need and Animal Welfare. April, 11-12.

Lyons, S.M., Champ, M.A., Panem, S. and J.D. Willett. 1985. "Alternative Methods for Toxicity Testing,” Regulatory Policy Issues. April

Healthy People 2000: 1990, National Health Promotion and Disease Prevention Objectives: Full Report, With Commentary. DHHS Publication; (PHS) 91-50212. Pg 655. Jones and Bartlett Publishers, Sudbury, Massachusetts.

Willett, J.D. and D.D. Keefe, 1998. “A Pilot Project in Augmentative Distance Learning: George Mason University Graduate Course in Biochemistry”. AACE, 10th World Conference on Educational Multimedia and Hypermedia, Freiburg, Germany; June 20-25

Willett, James D. Biotechnology; in Encyclopedia of Global Change, Oxford University Press, NY, 2001.

Brinkac, Lauren M. and J.D. Willett, 2002. “Sterol Biosynthesis: Gene Loss in Caenorhabditis elegans?”. Bioinformatics and Pharmacogenomics Symposium. Richmond Virginia, USA.

Willett James D, Richard Troast, , and Gita Sudama, 2002. “ Effect of Environmental Lead on Small Molecule Patterns using HPLC in C. elegans”. Bioinformatics and Pharmacogenomics Symposium 2002. June 12-14, 2002 Richmond Virginia, USA

Willett, James D. and D.D. Keefe, 2002. “Information Technologies Role in Biochemical

Systematics”. World Conference on E-Learning in Corporate, Government, Healthcare & Higher Education, October 15-19, Montreal, Canada

Willett, James D, 2002. “Genomics, Proteomics: What’s Next?” Pharmacogenomics 3(6) 727-728

Willett, James D., Sudama G., Klotz F.and Volchikina S. 2003. Tryptophan Metabolite Profiles as Indicators of Macrophage Response to Pathogens. First International Conference - Crossing Boundaries: Medical Biodefense & Civilian Medicine November 23-25, 2003 Hilton Arlington & Towers, Arlington, Virginia

Willett, James D. 2003. Metabolic Profiling in the Exploration of Mechanisms of Toxicity: Lead in Caenorhabditis elegans. Metabolic Profiling: Pathways to Discovery CHI’s 3rd annual meeting. December 8-9. The Hyatt Regency Princeton. Princeton, New Jersey

Willett, James D., Troast, R. and Sudama G., 2004. A New Technique for Assessing Lead Bioavailability. AEHS, 14th Annual West Coast Conference on Soils, Sediments and Water. March 15-18, Mission Valley Marriott, San Diego, California

Keefe, David D. and James D. Willett. 2004. Points of view: A Case for PowerPoint as a Faculty Authoring system. Cell Biology Education. Vol 3, 46-47

Willett, James D., Troast Richard R. and Gita Sudama., 2004. Probing Mechanisms of Toxicity through Metabolic Profiling: Lead and Caenorhabditis elegans. 2nd International Conference on Pathways, Networks and systems: Theory and Experiments. Aldemar Knossos Royal, Crete Greece. October 15-20, 2004

Willett, James D. and David D. Keefe. 2004. E-Learning Enhances Situated Learning in Molecular Biosciences, Pgs. 1019-1024. Published proceedings. AACE, E-Learn 2004. World Conference on E-Learning in Corporate, Government, Healthcare and Higher Education. Washington, DC, USA, November 1-5, 2004

Willett, James D.,and Alexander Lazarev., 2005. Assessment of Physiologic State Change and Toxicity; An Integrated systems Biology Approach. 39th Toxicology and Risk Assessment Conference, 25-28 April. Holiday Inn Fairborn, Ohio. Co-sponsored by, EPA, DOD, NIOSH and NAS

Willett, James D. 2005. Studies of Lead Toxicity through Metabolic Profiling in C.elegans. Gordon Research Conference on Toxicogenomics. June 5-10, Colby-Sawyer College, New London, NH.

Willett, James D., 2005. Probing Mechanisms of Toxicity through Metabolic Profiling-What can it reveal? (Invited, platform presentation.) IBC’s Inaugural International Conference on Metabolic Profiling: Using Metabolomics Technology to Accelerate Drug Discovery and Development. November 14-15, 2005. Hilton Durham Hotel, Durham, North Carolina. Proceedings posted online by IBC

Troast R.,Sudama G. and J.D.Willett, 2006. The Use of Genomic Markers in Caenorhabditis elegans as Bioindicators for Environmental Lead Exposure: A Replacement for Current in-vivo and in-vitro Systems? International Society of Environmental Bioindicators and the International Union of Biological Sciences (IUBS) Commission on Bioindicators. April 24-26, 2006. The Conference Center at the Maritime Institute, Maryland USA.

Troast R., Sudama G.and James D. Willett, 2007. Identification of an Exposure Based Biomarker for Lead using Caenorhabditis elegans, Environmental Science and Technology 2007 (I) 444-450. Proceedings from the Third International Conference on Environmental Science and Technology, held August 6-9, 2007 Huston, Texas, USA ISBN 978-0976885382

Troast R.and James D. Willett, 2008. Using C elegans as a Tool for Identifying Environmental Lead Contamination: A new endpoint for relating exposures to lead risk

Environmental Bioindicators: 3:68-73, 2008

Neeraja Podugu, Gita Sudama and James D Willett, 2008. Peer reviewed poster presentation,: CE Aging, Stress, Pathogenesis, and Heterochrony: C. elegans Topic Meeting #4. Lead's effect on purine metabolism in the nematode Caenorhabditis elegans. August 2-6, 2008 University of Wisconsin, Madison Wisconsin

James D. Willett; Neeraja Podugu; Gita Sudama; John J. Kopecky; and Jenefir Isbister

J Gerontol A Biol Sci Med Sci. 2010 May; 65A(5): 457–467. Applications of Cold Temperature Stress to Age Fractionate Caenorhabditis elegans: A Simple Inexpensive Technique

Internal Presentations:

Kathryn Melvin, John Kopecky, Neeraja Podugu, Gita Sudama, Jenifer Isbister and James D. Willett, 2008 Age fractionation of C. elegans using cold temperature stress George Mason University Aspiring Scientist Summer Internship; Aug 25, 2008

PAPERS PRESENTED AT MEETINGS:

“Essential Biologic Concepts in Bioinformatics for Computer Scientists and IT Specialists”. April 29, 2002. The BIO IT First Annual Conference, McClean Virginia

“Nematodes as Biomarkers for Lead Toxicity.” EPA Super Fund Meeting,

Coerd’Alene Idaho May 22, 2000.

Universities: Partners in Economic Development.” R. Cypess, H.E. Davis, J. Miller, J. D. Willett and J. Schofield. SCUP-33 International Conference, Vancouver BC, July 16-22, 1998

Establishing age synchrony in xenic populations of C. elegans: Problems and Solutions." J.A. Bollinger and J.D. Willett. Poster session presented at the Second International Conference on C. elegans, Cold Spring Harbor Laboratories, Cold Spring Harbor, New York, May 10-13, 1979.

"Age dependent variations in cyclic nucleotide and prostaglandin levels in the nematode Panagrellus redivivus." J.D. Willett, I. Rahim and J.A. Bollinger. Invited poster session: Winter Gordon Research Conference of the Biology of Aging. January 22-26, 1979, Santa Barbara, California.

"Determination of cyclic nucleotides and ATP in Aphelenchus avanae in the free-living and anhydrobiotic state." J.D. Willett, D.W. Freckman and S.D. Van Gundy. Presented at the 3rd International Congress of Plant Pathology, Munchen. August 16-23, 1978.

"Determination of ATP levels in Aphelenchus avanae in the free living and anhydrobiotic state." J.D.Willett, D.W. Freckman, and S.D. Van Gundy. Presented at the Seventeenth Annual Meeting of the Society of Nematologists. August 7-10, 1978, Hot Springs, Arkansas.

Cyclic Nucleotide Levels in Tissues of the Free-Living Nematode, Panagrellus redivivus and Their Variation With Age." J.D. Willett I. Rahim and J.A. Bollinger. Presented at the Biochemistry Meeting of The American Association of Biological Chemists, June 1978.

Variations in Prostaglandin (PFG) Levels with Age in the Nematode Panagrellus redivivus." J.D.Willett and J.A. Bollinger. Presented at the 7th Annual National Meeting of the American Aging Association, October 1, 1977.

Alterations in Cyclic Nucleotide Levels with Age in the Free-Living Nematode, Panagrellus redivivus." J.D.Willett, 1. Rahim, and J.A. Bollinger. Presented at the 7th Annual National Meeting of the American Aging Association, October 1, 1977.

"Trace Determination of Chromium in Biological Materials by Reversed Phase High Pressure Liquid Chromatography." J.D. Willett, 1. Rahim, and J.A. Bollinger. Presented at the 32nd Northwest Regional Meeting of the American Chemical Society, June 1977.

"A Modification of the Standard Fluorescence Assay for Serotonin (5hydroxytryptamine) Allowing Detection at the picomole Level." J.D. Willett, P.M. Findeis, and E. Schulz. Presented at the 32nd Northwest Regional Meeting of the American Chemical Society, June 1977.

"Alternations in c-AMP and c-GMP Levels with Age in the Free-Living Nematode, Panagrellus redivivus." J.D. Willett, T. Rahim and J.A. Bollinger. Presented at the 32nd Northwest Regional Meeting of the American Chemical Society, June 1977.

"Cyclic-AMP and GMP Levels in Tissues of the Free-Living Nematode Panagrellus redivivus."

J.D. Willett, T. Rahim and J.A. Bollinger. Presented at the 32nd Northwest Regional Meeting of the American Chemical Society, June 1977.

"A Method for the Picomole Determination of Chromium by High Pressure Liquid

Chromatography." P. Knight and J.D. Willett. Presented to the Idaho Academy of Science, April 1976.

"The Pyrolytic Behavior of Cyclic Dithioketals." M. Mohammadi and J.D. Willett. Presented at the 30th Annual Meeting of the American Chemical Society, June 1975.

"Lanosterol Utilization in Nematodes." J.A. Gerick and J.D. Willett. Presented to the Idaho Academy of Science, April 1975.

"Fatty Acids of Panagrellus redivivus." D. McIntosh and J.D. Willett Presented to the Idaho Academy of Science, April 1975.

"Lanthanide Ions and Probes of Calcium Transport." W.P. Tew and J.D. Willett. Presented to the Idaho Academy of Science, April 1975.

p-(Methylthio)-benzoates. Versatile Alcohol Derivatives." E.P. Brody and J.D. Willett. Presented to the Idaho Academy of Science, April l975.

"4-Hydroxytryptamine and Free-Living Nematodes." G.L. Gilliland, R.M. Holt, S.C. Cooper and J.D.Willett. Presented to the Idaho Academy of Science, April 1975.

"Inhibition of Calcium Ion Transport in the Small Intestine of the Rat by Neodinium and Other Lanthanide Ions." J.D. Willett and W.P. Tew. Presented at the 29th annual Northwest Regional Meeting of the American Chemical Society, June 1974.

"The Isolation and Identification of Hydrocarbon from Plant Root Exudates of Seedlings of Beta vulgaris." J.D. Willett and E.P. Brody. Presented at the 47th Annual Meeting of the Northwest Scientific Association, Vancouver, B.C., May 9-11, 1974.

"The Relation of Trace Metals in the Soil to Infestations by the Plant Parasitic Nematode, Heterodera schachtii.” M. McMakin and J.D. Willett. Presented to the Environmental Chemistry Division, Pacific Coast Conference on Chemistry and Spectroscopy, October, 1972, San Francisco, California.

“Fatty Acid Trithiocarbonates as Aids in Determining Double Bond Positions in Unsaturated Fatty Acids”. J.D. Willett and D. J. McIntosh. Presented at the 27th Annual Northwest Meeting of the American Chemical Society, July 16, 1972.

"Pyrolytic Studies of Cyclic Dithioketals." J.D. Willett and M. Mohammadi. Presented at the 27th Annual Northwest Regional Meeting of the American Chemical Society, July 15, 1972.

"Trace Metal Content of Cysts of the Sugar Beet Cyst Nematode, Heterodera schachtii." M. McMakin and J.D. Willett. Presented to the Idaho Academy of Sciences, April 1972.

"Electron Impact Induced Fragmentation of Ethylene Dithioketals." M. Mohammadi and J.D. Willett. Presented to the Idaho Academy of Sciences, April 1972.

"Non-Polar Fluorescent Probes." J.D. Willett and B.L. Miller. Presented to the Idaho Academy of Science, April 1971.

"The Electron Impact Induced Fragmentation of Cyclic Dithioketals, I. A Comparison with Photochemistry." J.D. Willett and M. Mohammadi. Presented at the 161st National Meeting of the American Chemical Society, April 1971.

"Sterol Biosynthesis in the Free-Living Nematode, Panagrellus redivivus." J.D. Willett and W. Downey. Presented at the 26th Annual Northwest Regional Meeting of the American Chemical Society, June 1971.

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