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Study in Children Shows How to Cut the Risk of a Blood Clot in Leg Artery
During Cardiac Catheterization
Using Tiny 3 French Catheter in Infants and Sealing the Access Site With Hemostatic Patch
Yield Dramatic Reductions in Risk
Las Vegas, Nev. (May 26, 2014) — For infants with congenital heart disease who undergo cardiac catheterization via femoral artery needle puncture in the thigh, two key steps can reduce the risk by two-thirds of a blood clot obstructing flow. The first step is to choose a slender tube about the diameter of a piece of angel hair pasta to pass through the femoral artery on the way to the heart, and the second is to use a special patch to seal the puncture site and quickly stop the bleeding, according to a study reported this week at the SCAI 2014 Scientific Sessions.
The study, which involved children under the age of 18 treated in 21 pediatric cardiac catheterization laboratories, drew data from the Congenital Cardiovascular Interventional Study Consortium (CCISC) registry. It focused on factors that influence the risk that, during cardiac catheterization, a blood clot will form in the femoral artery and obstruct blood flow in the leg. The consequences of this type of femoral artery compromise can be severe and include loss of oxygen-rich blood flow to the leg, possibly necessitating amputation; pain while walking; differences in the length of the two legs; and an inability to use the femoral artery as the access site for future cardiac procedures.
“We found that small infants are at particularly high risk,” said Thomas J. Forbes, M.D., FSCAI, cath lab director at Children’s Hospital of Michigan and a professor of pediatrics at Wayne State University, both in Detroit. “Because infants with complex heart disease require multiple catheterizations, avoiding obstruction of the femoral artery is critical.”
For the study, Dr. Forbes and fellow researchers analyzed data from the CCISC registry on a total of 8,958 instances in which the femoral artery was used as the access site for passing a slender tube, or catheter, through the body’s arteries and into the heart. They defined femoral artery compromise as an obstructive blood clot that required treatment with clot-dissolving medication, an interventional procedure or surgery.
Overall researchers observed a very low rate of femoral artery compromise (1.1%). Small infants were at significantly increased risk, however. When infants weighing less than 12 kg were compared to children weighing more than 18 kg, the risk of femoral artery compromise was 6.3 to 7.6 times as high. Children who had an interventional procedure, rather than simply undergoing diagnostic catheterization, faced double the risk of femoral artery compromise. In addition, the risk was 6.4 times higher if a closure device was used to plug the arterial puncture site, as compared to the use of manual pressure alone to stop access-site bleeding.
On the other hand, when a special hemostatic patch was used to seal the wound, the risk of femoral compromise was reduced by about two-thirds as compared with manual pressure alone. Hemostatic patches are made of a variety of materials that encourage blood cells to plug the puncture site by speeding up formation of a scab on the wound.
In addition, among infants weighing less than 12 kg, the risk of femoral compromise was cut by more than two-thirds when a very slender sheath and catheter—size 3 French, or 1mm in diameter—was threaded through the femoral artery, rather than the most commonly used size, 4 French or 1.35mm in diameter.
The true rate of femoral artery compromise is probably underestimated, Dr. Forbes said, despite all the efforts to document this serious complication in multicenter registries. That’s because physicians typically identify lack of blood flow through the femoral artery by checking for the loss of a pulse in the leg. However, using this method, many blood clots go undetected.
“The challenge is that there is no standardized diagnostic approach to pulse loss after femoral arterial access,” Dr. Forbes said. “We think it’s very important to use Duplex ultrasound to diagnose a blood clot in the femoral artery in a timely fashion.”
Dr. Forbes reports no potential conflicts of interest.
Dr. Forbes will present the study “Femoral Artery Compromise from Cardiac Catheterization in Children – A Multicenter Study by the CCISC (Congenital Cardiovascular Interventional Study Consortium)” in an oral abstract session on Thursday, May 29, 2014, 3:30 p.m. to 4:30 p.m. (Pacific Time).
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About SCAI
The Society for Cardiovascular Angiography and Interventions is a 4,000-member professional organization representing invasive and interventional cardiologists in approximately 70 nations. SCAI's mission is to promote excellence in invasive/interventional cardiovascular medicine through physician education and representation, and advancement of quality standards to enhance patient care. SCAI's public education program, SecondsCount, offers comprehensive information about cardiovascular disease. For more information about SCAI and SecondsCount, visit or . Follow @SCAI and @SCAINews on Twitter for the latest heart health news, and use #SCAI2014 to join the annual meeting conversation.
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