APVMA Special Gazette 1 April 2020

Nintedanib caused a slight decrease in urine glucose excretion, and increases in urine volume, urine sodium, calcium and beta-N-acetylglucosaminidase in rats at 100 mg/kg/day PO after the first dose. The effects on urine volume, sodium and calcium were reversible by Day 6 despite continued dosing. ................
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