Physiotherapy – Respiratory Management



Canberra Hospital and Health ServicesClinical Guideline Physiotherapy – Respiratory ManagementContents TOC \h \z \t "Heading 1,1,Heading 2,2" Contents PAGEREF _Toc507407244 \h 1Guideline Statement PAGEREF _Toc507407245 \h 3Scope PAGEREF _Toc507407246 \h 3Section 1 – Cough assist to enhance pulmonary secretion clearance PAGEREF _Toc507407247 \h 3Background PAGEREF _Toc507407248 \h 3Indications, Precautions and Contraindications PAGEREF _Toc507407249 \h 4Equipment and Assembly PAGEREF _Toc507407250 \h 5Procedure PAGEREF _Toc507407251 \h 5Cleaning and Maintenance 7 PAGEREF _Toc507407252 \h 7Section 2 – Inspiratory Muscle Training PAGEREF _Toc507407253 \h 8Background PAGEREF _Toc507407254 \h 8Acute IMT Program: PAGEREF _Toc507407255 \h 9Equipment PAGEREF _Toc507407256 \h 9Procedure PAGEREF _Toc507407257 \h 10Guidelines for Concern PAGEREF _Toc507407258 \h 11Outcome/Progression Measures PAGEREF _Toc507407259 \h 11Patient Education PAGEREF _Toc507407260 \h 11Documentation PAGEREF _Toc507407261 \h 11Cleaning Of Equipment PAGEREF _Toc507407262 \h 11Threshold IMT Device PAGEREF _Toc507407263 \h 12Indications PAGEREF _Toc507407264 \h 12Equipment PAGEREF _Toc507407265 \h 12Procedure PAGEREF _Toc507407266 \h 12Guidelines for Concern PAGEREF _Toc507407267 \h 13Outcome/Progression Measures PAGEREF _Toc507407268 \h 13Cleaning Of Equipment PAGEREF _Toc507407269 \h 13Section 3 – Hyperinflation PAGEREF _Toc507407270 \h 13Background PAGEREF _Toc507407271 \h 13Indications for Hyperinflation36 PAGEREF _Toc507407272 \h 14Outcome Measures PAGEREF _Toc507407273 \h 14Precautions for Hyperinflation37 PAGEREF _Toc507407274 \h 15Contraindications for Hyperinflation PAGEREF _Toc507407275 \h 15Performing MHI PAGEREF _Toc507407276 \h 15Performing VHI PAGEREF _Toc507407277 \h 17Section 4 – Induced Sputum Collection PAGEREF _Toc507407278 \h 18Referrals - general PAGEREF _Toc507407279 \h 19Weekends/out of business hours PAGEREF _Toc507407280 \h 19Safety PAGEREF _Toc507407281 \h 20Preparation PAGEREF _Toc507407282 \h 20Equipment PAGEREF _Toc507407283 \h 21Procedure PAGEREF _Toc507407284 \h 21Cleaning PAGEREF _Toc507407285 \h 22Implementation PAGEREF _Toc507407286 \h 22Related Policies, Procedures, Guidelines and Legislation PAGEREF _Toc507407287 \h 22References PAGEREF _Toc507407288 \h 23Definition of Terms PAGEREF _Toc507407289 \h 26Search Terms PAGEREF _Toc507407290 \h 26Attachments PAGEREF _Toc507407291 \h 26Attachment 1 – Assessing Peak cough flow PAGEREF _Toc507407292 \h 28Attachment 2 – Assembly of Cough Assist Machine PAGEREF _Toc507407293 \h 29Attachment 3 –Modifying Cough Assist Machine settings PAGEREF _Toc507407294 \h 30Attachment 4 – Cough Assist Machine Competency Assessment for Physiotherapists PAGEREF _Toc507407295 \h 32Attachment 5 – Physiotherapy Competency Assessment Inspiratory Muscle Training PAGEREF _Toc507407296 \h 34Attachment 6 –Hyperinflation Competency Assessment PAGEREF _Toc507407297 \h 36Attachment 7 – Ventilator Assessment Tool for Physiotherapists PAGEREF _Toc507407298 \h 39Attachment 9 – List of negative pressure rooms in CHHS PAGEREF _Toc507407299 \h 46Attachment 10 – Induced Sputum mouthpiece components and assembly PAGEREF _Toc507407300 \h 47Attachment 11 – Flowchart for requests for Induced Sputum collection PAGEREF _Toc507407301 \h 48Guideline StatementThis guideline outlines respiratory interventions performed by physiotherapists at Canberra Hospital and Health Services (CHHS). BackgroundThis document has been developed to guide physiotherapists working in acute care who utilise Cough Assist, inspiratory muscle training, manual and ventilator hyperinflation and who perform induced sputum procedures. Key ObjectiveTo ensure the delivery of safe, evidence based, best practice respiratory management in adult and paediatric patients by acute care physiotherapists.Back to Table of ContentsScopeThis document applies to the following staff working within their scope of practice:Physiotherapists Nursing staff Physiotherapy students under direct supervisionCarers trained or under instruction/prescription by physiotherapists.Back to Table of ContentsSection 1 – Cough assist to enhance pulmonary secretion clearanceThis section pertains to usage of the Emerson CA-3200 cough assist machine and the Phillips Respironics Cough Assist E70, in suitable adult and paediatric patients at the CHHS, who have the problem of retained secretions and an ineffective cough. The cough assist machine (CAM) is an optional adjunct to standard physiotherapy treatment.Background Coughing is an essential reflex which clears excess secretions and foreign matter from the airway. The essential components include deep inspiration, closure of the glottis and forceful expiration. In order for a cough to be effective, an adequate expiratory flow must be generated. A normal peak expiratory flow is in the range of 6-12L/sec ADDIN EN.CITE <EndNote><Cite><Author>Irwin</Author><Year>1998</Year><RecNum>1219</RecNum><DisplayText><style face="superscript">1</style></DisplayText><record><rec-number>1219</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503634836">1219</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Irwin, R. S.</author><author>Boulet, L. P.</author><author>Cloutier, M. M.</author><author>Fuller, R.</author><author>Gold, P. M.</author><author>Hoffstein, V.</author><author>Ing, A. J.</author><author>McCool, F. D.</author><author>O&apos;Byrne, P.</author><author>Poe, R. H.</author><author>Prakash, U. B.</author><author>Pratter, M. R.</author><author>Rubin, B. K.</author></authors></contributors><titles><title>Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians</title><secondary-title>Chest</secondary-title></titles><periodical><full-title>Chest</full-title></periodical><pages>133S-181S</pages><volume>114</volume><number>2 Suppl Managing</number><keywords><keyword>Adult</keyword><keyword>Antitussive Agents/therapeutic use</keyword><keyword>Child</keyword><keyword>*Cough/etiology/physiopathology/prevention &amp; control/therapy</keyword><keyword>Expectorants/therapeutic use</keyword><keyword>Humans</keyword><keyword>Reflex/physiology</keyword></keywords><dates><year>1998</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0012-3692 (Print)&#xD;0012-3692 (Linking)</isbn><accession-num>9725800</accession-num><urls><related-urls><url> with peak cough flows reaching up to 20L/sec. Cough strength can be reduced in patients with inspiratory and expiratory muscle weakness, leading to low lung volumes and difficulty clearing secretions2. Mechanical insufflation-exsufflation (in-exsufflation) via a CAM can assist in the removal of pulmonary secretions without the need for more invasive techniques such as open (guedel or nasopharyngeal) airway suctioning. Mechanical in-exsufflation consists of insufflating the lungs with positive pressure, followed by a quick change to negative pressure exsufflation. This creates a peak and sustained flow high enough to mimic a cough and thereby to loosen and move secretions toward the oropharynx for suctioning or expectoration ADDIN EN.CITE <EndNote><Cite><Author>Homnick</Author><Year>2007</Year><RecNum>1220</RecNum><DisplayText><style face="superscript">2</style></DisplayText><record><rec-number>1220</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503635071">1220</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Homnick, D. N.</author></authors></contributors><auth-address>Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Kalamazoo Center for Medical Studies, Michigan State University, 1000 Oakland Drive, Kalamazoo MI 49008, USA. homnick@kcms.msu.edu</auth-address><titles><title>Mechanical insufflation-exsufflation for airway mucus clearance</title><secondary-title>Respir Care</secondary-title></titles><periodical><full-title>Respir Care</full-title></periodical><pages>1296-305; discussion 1306-7</pages><volume>52</volume><number>10</number><keywords><keyword>Airway Obstruction/etiology/*therapy</keyword><keyword>Cough</keyword><keyword>Equipment Design</keyword><keyword>Humans</keyword><keyword>Insufflation/*instrumentation/methods</keyword><keyword>*Mucus</keyword></keywords><dates><year>2007</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>0020-1324 (Print)&#xD;0020-1324 (Linking)</isbn><accession-num>17894900</accession-num><urls><related-urls><url>. Published pressures which were reported to be clinically effective include ranges of +15 to +40cmH2O for insufflation and -20 to -45cmH2O for exsufflation ADDIN EN.CITE <EndNote><Cite><Author>Whitney</Author><Year>2002</Year><RecNum>1277</RecNum><DisplayText><style face="superscript">3</style></DisplayText><record><rec-number>1277</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503636096">1277</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Whitney, J. A.</author><author>Harden, B.</author><author>Keilty, S.</author></authors></contributors><titles><title>Assisted cough: a new technique</title><secondary-title>Physiotherapy</secondary-title></titles><periodical><full-title>Physiotherapy</full-title></periodical><pages>201-207</pages><volume>88</volume><number>4</number><dates><year>2002</year></dates><urls></urls></record></Cite></EndNote>3 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaXN6bmVyPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48

UmVjTnVtPjEyNzg8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40LDU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4xMjc4PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3Nl

cnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjE1MDM2MzY2MjMiPjEyNzg8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxpc3puZXIsIEsuPC9hdXRob3I+PGF1

dGhvcj5GZWluYmVyZywgTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxl

cz48dGl0bGU+Q291Z2ggYXNzaXN0IHN0cmF0ZWd5IGZvciBwdWxtb25hcnkgdG9pbGV0aW5nIGlu

IHZlbnRpbGF0b3IgZGVwZW5kZW50IHNwaW5hbCBjb3JkIGluanVyZWQgcGF0aWVudHMuPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPlJlaGFiaWxpdGF0aW9uIE51cnNpbmc8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5SZWhhYmlsaXRhdGlvbiBOdXJzaW5n

PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MjE4LTIyMTwvcGFnZXM+PHZvbHVtZT4z

MTwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA2PC95ZWFyPjwvZGF0

ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkNoYXR3aW48L0F1

dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNOdW0+MTI3OTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+MTI3OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

InM5eHd6ZHZwbjI5ZXdzZXJ0YXA1d3ZkYjk5ZnJlZDVwMjAwdiIgdGltZXN0YW1wPSIxNTAzNjM2

NzM3Ij4xMjc5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGF0d2lu

LCBNLjwvYXV0aG9yPjxhdXRob3I+U2ltb25kcywgQS4gSy48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5BY2FkZW1pYyBhbmQgQ2xpbmljYWwgRGVwYXJ0bWVu

dCBvZiBTbGVlcCBhbmQgQnJlYXRoaW5nLCBSb3lhbCBCcm9tcHRvbiBIb3NwaXRhbCwgU3lkbmV5

IFN0cmVldCwgTG9uZG9uLCBTVzMgNk5QLCBVbml0ZWQgS2luZ2RvbS4gbS5jaGF0d2luQHJiaHQu

bmhzLnVrPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGFkZGl0aW9uIG9mIG1lY2hh

bmljYWwgaW5zdWZmbGF0aW9uL2V4c3VmZmxhdGlvbiBzaG9ydGVucyBhaXJ3YXktY2xlYXJhbmNl

IHNlc3Npb25zIGluIG5ldXJvbXVzY3VsYXIgcGF0aWVudHMgd2l0aCBjaGVzdCBpbmZlY3Rpb248

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UmVzcGlyIENhcmU8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5SZXNwaXIgQ2FyZTwvZnVsbC10aXRsZT48L3Bl

cmlvZGljYWw+PHBhZ2VzPjE0NzMtOTwvcGFnZXM+PHZvbHVtZT41NDwvdm9sdW1lPjxudW1iZXI+

MTE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29y

ZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BdXNjdWx0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+

Qy1SZWFjdGl2ZSBQcm90ZWluL2FuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3

b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MtT3Zl

ciBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkZhdGlndWUvY29tcGxpY2F0aW9uczwva2V5d29y

ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPipJbnN1ZmZsYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TGV1a29jeXRlIENvdW50PC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TmV1cm9tdXNjdWxhciBEaXNlYXNl

cy8qY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFRoZXJhcHkvKm1ldGhvZHM8L2tleXdvcmQ+PGtl

eXdvcmQ+UmVzcGlyYXRvcnkgVHJhY3QgSW5mZWN0aW9ucy9jb21wbGljYXRpb25zLyp0aGVyYXB5

PC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bTwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVsdDwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+Tm92PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAyMC0xMzI0IChQcmludCkm

I3hEOzAwMjAtMTMyNCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk4NjM4MzE8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0u

bmloLmdvdi9wdWJtZWQvMTk4NjM4MzE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNv

cmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaXN6bmVyPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48

UmVjTnVtPjEyNzg8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij40LDU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4xMjc4PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3Nl

cnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjE1MDM2MzY2MjMiPjEyNzg8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxpc3puZXIsIEsuPC9hdXRob3I+PGF1

dGhvcj5GZWluYmVyZywgTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxl

cz48dGl0bGU+Q291Z2ggYXNzaXN0IHN0cmF0ZWd5IGZvciBwdWxtb25hcnkgdG9pbGV0aW5nIGlu

IHZlbnRpbGF0b3IgZGVwZW5kZW50IHNwaW5hbCBjb3JkIGluanVyZWQgcGF0aWVudHMuPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPlJlaGFiaWxpdGF0aW9uIE51cnNpbmc8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5SZWhhYmlsaXRhdGlvbiBOdXJzaW5n

PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MjE4LTIyMTwvcGFnZXM+PHZvbHVtZT4z

MTwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA2PC95ZWFyPjwvZGF0

ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkNoYXR3aW48L0F1

dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNOdW0+MTI3OTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+MTI3OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

InM5eHd6ZHZwbjI5ZXdzZXJ0YXA1d3ZkYjk5ZnJlZDVwMjAwdiIgdGltZXN0YW1wPSIxNTAzNjM2

NzM3Ij4xMjc5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGF0d2lu

LCBNLjwvYXV0aG9yPjxhdXRob3I+U2ltb25kcywgQS4gSy48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5BY2FkZW1pYyBhbmQgQ2xpbmljYWwgRGVwYXJ0bWVu

dCBvZiBTbGVlcCBhbmQgQnJlYXRoaW5nLCBSb3lhbCBCcm9tcHRvbiBIb3NwaXRhbCwgU3lkbmV5

IFN0cmVldCwgTG9uZG9uLCBTVzMgNk5QLCBVbml0ZWQgS2luZ2RvbS4gbS5jaGF0d2luQHJiaHQu

bmhzLnVrPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGFkZGl0aW9uIG9mIG1lY2hh

bmljYWwgaW5zdWZmbGF0aW9uL2V4c3VmZmxhdGlvbiBzaG9ydGVucyBhaXJ3YXktY2xlYXJhbmNl

IHNlc3Npb25zIGluIG5ldXJvbXVzY3VsYXIgcGF0aWVudHMgd2l0aCBjaGVzdCBpbmZlY3Rpb248

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UmVzcGlyIENhcmU8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5SZXNwaXIgQ2FyZTwvZnVsbC10aXRsZT48L3Bl

cmlvZGljYWw+PHBhZ2VzPjE0NzMtOTwvcGFnZXM+PHZvbHVtZT41NDwvdm9sdW1lPjxudW1iZXI+

MTE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29y

ZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BdXNjdWx0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+

Qy1SZWFjdGl2ZSBQcm90ZWluL2FuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3

b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MtT3Zl

ciBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkZhdGlndWUvY29tcGxpY2F0aW9uczwva2V5d29y

ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPipJbnN1ZmZsYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TGV1a29jeXRlIENvdW50PC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TmV1cm9tdXNjdWxhciBEaXNlYXNl

cy8qY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFRoZXJhcHkvKm1ldGhvZHM8L2tleXdvcmQ+PGtl

eXdvcmQ+UmVzcGlyYXRvcnkgVHJhY3QgSW5mZWN0aW9ucy9jb21wbGljYXRpb25zLyp0aGVyYXB5

PC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bTwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVsdDwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+Tm92PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAyMC0xMzI0IChQcmludCkm

I3hEOzAwMjAtMTMyNCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk4NjM4MzE8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0u

bmloLmdvdi9wdWJtZWQvMTk4NjM4MzE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNv

cmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA 4,5. This range of pressures has also been reported to be safe and comfortable in children ADDIN EN.CITE <EndNote><Cite><Author>Fauroux</Author><Year>2008</Year><RecNum>1280</RecNum><DisplayText><style face="superscript">6</style></DisplayText><record><rec-number>1280</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503636814">1280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fauroux, B.</author><author>Guillemot, N.</author><author>Aubertin, G.</author><author>Nathan, N.</author><author>Labit, A.</author><author>Clement, A.</author><author>Lofaso, F.</author></authors></contributors><auth-address>Assistance Publique-Hopitaux de Paris, Hopital Armand Trousseau, Pediatric Pulmonary Department, Research unit INSERM UMR-S 719, Universite Pierre et Marie Curie-Paris 6, 28 Ave du Docteur Arnold Netter, Paris, F-75012 France. brigitte.fauroux@trs.aphp.fr</auth-address><titles><title>Physiologic benefits of mechanical insufflation-exsufflation in children with neuromuscular diseases</title><secondary-title>Chest</secondary-title></titles><periodical><full-title>Chest</full-title></periodical><pages>161-8</pages><volume>133</volume><number>1</number><keywords><keyword>Adolescent</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Cough</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>*Insufflation</keyword><keyword>Male</keyword><keyword>Muscular Atrophy, Spinal/therapy</keyword><keyword>Muscular Dystrophy, Duchenne/therapy</keyword><keyword>Neuromuscular Diseases/*therapy</keyword><keyword>Prospective Studies</keyword><keyword>Respiratory Function Tests</keyword><keyword>Respiratory Physiological Phenomena</keyword></keywords><dates><year>2008</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0012-3692 (Print)&#xD;0012-3692 (Linking)</isbn><accession-num>18071020</accession-num><urls><related-urls><url>, Precautions and ContraindicationsIndications ADDIN EN.CITE <EndNote><Cite><RecNum>1221</RecNum><DisplayText><style face="superscript">3,4,7</style></DisplayText><record><rec-number>1221</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503635515">1221</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Emerson 3200 User Manual</title></titles><dates></dates><urls><related-urls><url> app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503636096">1277</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Whitney, J. A.</author><author>Harden, B.</author><author>Keilty, S.</author></authors></contributors><titles><title>Assisted cough: a new technique</title><secondary-title>Physiotherapy</secondary-title></titles><periodical><full-title>Physiotherapy</full-title></periodical><pages>201-207</pages><volume>88</volume><number>4</number><dates><year>2002</year></dates><urls></urls></record></Cite><Cite><Author>Liszner</Author><Year>2006</Year><RecNum>1278</RecNum><record><rec-number>1278</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503636623">1278</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liszner, K.</author><author>Feinberg, M.</author></authors></contributors><titles><title>Cough assist strategy for pulmonary toileting in ventilator dependent spinal cord injured patients.</title><secondary-title>Rehabilitation Nursing</secondary-title></titles><periodical><full-title>Rehabilitation Nursing</full-title></periodical><pages>218-221</pages><volume>31</volume><number>5</number><dates><year>2006</year></dates><urls></urls></record></Cite></EndNote>3,4,7 :Any patient who is at risk or has evidence of retained secretions with a weak cough or low lung volumes due to:Neuromuscular deficits (i.e. muscular dystrophy, myasthenia gravis, poliomyelitis, motor neurone disease, spinal cord injury, aspiration following cerebrovascular accident etc.).Intrinsic lung disease such as COPD, cystic fibrosis or bronchiectasis.Note: CAM treatment is usually not appropriate for an acutely unwell/deteriorating patient with a high respiratory rate, where intubation is likely required for sputum clearance. Outcome measuresPeak cough flow (refer to Attachment 1)Vital capacity via spirometryOxygen saturationsChest radiograph (CXR)Auscultation PalpationCough quality Volume/ consistency of sputum Contraindications ADDIN EN.CITE <EndNote><Cite><RecNum>1221</RecNum><DisplayText><style face="superscript">4,7</style></DisplayText><record><rec-number>1221</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503635515">1221</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Emerson 3200 User Manual</title></titles><dates></dates><urls><related-urls><url> app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503636623">1278</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liszner, K.</author><author>Feinberg, M.</author></authors></contributors><titles><title>Cough assist strategy for pulmonary toileting in ventilator dependent spinal cord injured patients.</title><secondary-title>Rehabilitation Nursing</secondary-title></titles><periodical><full-title>Rehabilitation Nursing</full-title></periodical><pages>218-221</pages><volume>31</volume><number>5</number><dates><year>2006</year></dates><urls></urls></record></Cite></EndNote>4,7Undrained pneumothorax or the presence of an intercostal catheter (ICC) with continuous leakUnstable cardiovascular system such as unstable arrhythmias, mean arterial pressure (MAP) <65, the presence of an Intra Aortic Balloon Pump (IABP); increasing inotropic or vasopressor support (as high intra-thoracic pressures may compromise venous return)Large lung abscess or bullaeRecent barotraumasPatients ventilated on lung protective strategy for Acute Respiratory Distress Syndrome (ARDS), severe pneumonia, pulmonary contusionsAcute bronchospasmPrecautions ADDIN EN.CITE <EndNote><Cite><Author>Liszner</Author><Year>2006</Year><RecNum>1278</RecNum><DisplayText><style face="superscript">4</style></DisplayText><record><rec-number>1278</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503636623">1278</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liszner, K.</author><author>Feinberg, M.</author></authors></contributors><titles><title>Cough assist strategy for pulmonary toileting in ventilator dependent spinal cord injured patients.</title><secondary-title>Rehabilitation Nursing</secondary-title></titles><periodical><full-title>Rehabilitation Nursing</full-title></periodical><pages>218-221</pages><volume>31</volume><number>5</number><dates><year>2006</year></dates><urls></urls></record></Cite></EndNote>4Ribs fractures excluding pneumothorax. This includes multiple rib fractures and flail segmentsPatients with cardiac compromise as increased thoracic pressures in the insufflation phase can reduce cardiac outputFacial fractures, facial trauma, sinus surgery. In this case a mouthpiece may be used as opposed to the facemask in consultation with senior physiotherapist/ medical staff. Equipment and AssemblyEquipmentEmerson CA-3200 Cough Assist machine or Phillips Respironics Cough Assist E70Patient circuit Bacterial/viral filterBreathing hoseConnector Patient interface (face mask, mouthpiece, or tracheostomy adapter)Pulse oximeterTissues or wall suction for sputum clearanceMask/eye protection for staff member if indicated (infection or multi-resistant organism) AssemblyConnect the machine to power and position it within easy reach.Connect the patient circuit to the machine (see Attachment 2). ProcedurePhysiotherapists may only utilise CAM as part of physiotherapy treatment once they have completed the CAM competency package with the appropriate HP3 Physiotherapist (Attachment 3).Identify indications for use of CAM and any precautions or contradictions and select the appropriate interface. If precautions exist, discuss with senior physiotherapist and medical staff prior to initiating cough assist. If the CAM is being used with a spinal cord patient, refer to the Physiotherapy - Adult Patient with a Spinal Cord Injury Guideline.Perform hand hygiene, apply personal protective equipment (PPE) and observe any other precautions.Explain the treatment and gain informed consent from the patient/carer. Assess appropriate outcome measures If assessing peak cough flow as indicated. Refer to Attachment 1 or Clinical Guideline: Physiotherapy- Adult Patient with a spinal cord injury, found on the policy register, on how to assess peak cough flow, Attachment 3. Appropriately position the patient to maximise ventilation. Alert: The Emerson CA-3200 does not support oxygen to be entrained into the circuit as it is an electrical hazard. If you need to entrain oxygen use the Phillips Respironics Cough Assist E70Select either automatic or manual mode. This depends on patient presentation but generally: Manual mode will be used for acutely unwell patients where the cough assist is used as a new treatment modality. Automatic mode is used in long term use of cough assist and for those patients with cough assist previously set up for the treatment of a chronic condition. Manual or automatic mode can be used in patients presenting to hospital with acute issues that use the cough assist as a long term treatment at home. This depends on patient presentation at the time of treatment. Titrate pressures delivered to the maximal expiratory and inspiratory pressures as tolerated by the patient by adjusting the machine parameters as per Attachment 4. This needs to be individualised depending on patient presentation. Alert: Tracheostomy/Endotracheal tube (ETT)If using a tracheostomy interface either:inflate cuff and perform treatment place speaking valve/cap over tracheostomy and perform therapy through mouth. Ensure cuff is completed deflated prior to placing speaking valve.Be sure to disconnect the patient from the CAM immediately after the cough cycle and allow adequate rest. Patients with an artificial airway may require higher pressures to achieve therapeutic levels due to the resistance to air flow created by the tube8.Determine the dosage: treatment can involve any combination of deep breaths (insufflations only) and cough/s (insufflations followed immediately by exsufflations) and should be individualised depending on patient presentation and tolerance. In patients with neuromuscular weakness, an attempt to cough should also be encouraged, whereas patients with emphysema should be encouraged to allow passive exsufflation as glottis closure and high intrathoracic pressures are thought to encourage distal collapse and ineffective cough4.If in automatic mode, therapy will commence as per the set parameters once the machine is in therapy mode. If in manual mode, deliver the set dosage of insufflations and exsufflations through the interface using the manual lever or foot pedal on the Philips Respironics Cough Assist E70. Insufflations should be delivered for 3 seconds. Incorporate adjunct techniques such as manual techniques, active cycle of breathing technique, saline nebuliser ADDIN EN.CITE <EndNote><Cite><Author>Liszner</Author><Year>2006</Year><RecNum>1278</RecNum><DisplayText><style face="superscript">4</style></DisplayText><record><rec-number>1278</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503636623">1278</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liszner, K.</author><author>Feinberg, M.</author></authors></contributors><titles><title>Cough assist strategy for pulmonary toileting in ventilator dependent spinal cord injured patients.</title><secondary-title>Rehabilitation Nursing</secondary-title></titles><periodical><full-title>Rehabilitation Nursing</full-title></periodical><pages>218-221</pages><volume>31</volume><number>5</number><dates><year>2006</year></dates><urls></urls></record></Cite></EndNote>4 and manual assisted coughPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaGl0bmV5PC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48

UmVjTnVtPjEyNzc8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4zLDg8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4xMjc3PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3Nl

cnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjE1MDM2MzYwOTYiPjEyNzc8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldoaXRuZXksIEouIEEuPC9hdXRob3I+

PGF1dGhvcj5IYXJkZW4sIEIuPC9hdXRob3I+PGF1dGhvcj5LZWlsdHksIFMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkFzc2lzdGVkIGNvdWdoOiBhIG5l

dyB0ZWNobmlxdWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UGh5c2lvdGhlcmFweTwvc2Vjb25k

YXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBoeXNpb3RoZXJhcHk8

L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4yMDEtMjA3PC9wYWdlcz48dm9sdW1lPjg4

PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMDI8L3llYXI+PC9kYXRl

cz48dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+R3VlcmluPC9BdXRo

b3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjEyODE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjEyODE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJz

OXh3emR2cG4yOWV3c2VydGFwNXd2ZGI5OWZyZWQ1cDIwMHYiIHRpbWVzdGFtcD0iMTUwMzYzNzE0

NSI+MTI4MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R3VlcmluLCBD

LjwvYXV0aG9yPjxhdXRob3I+Qm91cmRpbiwgRy48L2F1dGhvcj48YXV0aG9yPkxlcmF5LCBWLjwv

YXV0aG9yPjxhdXRob3I+RGVsYW5ub3ksIEIuPC9hdXRob3I+PGF1dGhvcj5CYXlsZSwgRi48L2F1

dGhvcj48YXV0aG9yPkdlcm1haW4sIE0uPC9hdXRob3I+PGF1dGhvcj5SaWNoYXJkLCBKLiBDLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNlcnZpY2UgZGUg

UmVhbmltYXRpb24gTWVkaWNhbGUgZXQgZCZhcG9zO0Fzc2lzdGFuY2UgUmVzcGlyYXRvaXJlLCBI

b3BpdGFsIGRlIGxhIENyb2l4IFJvdXNzZSwgTHlvbiwgRnJhbmNlLiBjbGF1ZGUuZ3VlcmluQGNo

dS1seW9uLmZyPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGVyZm9ybWFuY2Ugb2YgdGhl

IGNvdWdoYXNzaXN0IGluc3VmZmxhdGlvbi1leHN1ZmZsYXRpb24gZGV2aWNlIGluIHRoZSBwcmVz

ZW5jZSBvZiBhbiBlbmRvdHJhY2hlYWwgdHViZSBvciB0cmFjaGVvc3RvbXkgdHViZTogYSBiZW5j

aCBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5SZXNwaXIgQ2FyZTwvc2Vjb25kYXJ5LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlJlc3BpciBDYXJlPC9mdWxsLXRp

dGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTEwOC0xNDwvcGFnZXM+PHZvbHVtZT41Njwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Db3VnaC9waHlzaW9wYXRob2xv

Z3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+RXF1aXBtZW50IERlc2lnbjwva2V5d29yZD48

a2V5d29yZD5FeGhhbGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkZvcmNlZCBFeHBpcmF0b3J5IEZs

b3cgUmF0ZXMvcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW5zdWZmbGF0aW9uLyppbnN0cnVtZW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SW50

dWJhdGlvbiwgSW50cmF0cmFjaGVhbC8qaW5zdHJ1bWVudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

PlBoeXNpY2FsIFRoZXJhcHkgTW9kYWxpdGllcy8qaW5zdHJ1bWVudGF0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPlJlc3BpcmF0aW9uLCBBcnRpZmljaWFsLyppbnN0cnVtZW50YXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+UmVzcGlyYXRvcnkgSW5zdWZmaWNpZW5jeS9waHlzaW9wYXRob2xvZ3kvKnRoZXJh

cHk8L2tleXdvcmQ+PGtleXdvcmQ+VHJhY2hlb3N0b215LyppbnN0cnVtZW50YXRpb248L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1

ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjAtMTMyNCAoUHJpbnQpJiN4RDsw

MDIwLTEzMjQgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxODAxNTc3PC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5n

b3YvcHVibWVkLzIxODAxNTc3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC40MTg3L3Jlc3BjYXJlLjAxMTIxPC9lbGVjdHJvbmljLXJlc291cmNl

LW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaGl0bmV5PC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48

UmVjTnVtPjEyNzc8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4zLDg8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4xMjc3PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3Nl

cnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjE1MDM2MzYwOTYiPjEyNzc8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldoaXRuZXksIEouIEEuPC9hdXRob3I+

PGF1dGhvcj5IYXJkZW4sIEIuPC9hdXRob3I+PGF1dGhvcj5LZWlsdHksIFMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkFzc2lzdGVkIGNvdWdoOiBhIG5l

dyB0ZWNobmlxdWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UGh5c2lvdGhlcmFweTwvc2Vjb25k

YXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBoeXNpb3RoZXJhcHk8

L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4yMDEtMjA3PC9wYWdlcz48dm9sdW1lPjg4

PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMDI8L3llYXI+PC9kYXRl

cz48dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+R3VlcmluPC9BdXRo

b3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjEyODE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjEyODE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJz

OXh3emR2cG4yOWV3c2VydGFwNXd2ZGI5OWZyZWQ1cDIwMHYiIHRpbWVzdGFtcD0iMTUwMzYzNzE0

NSI+MTI4MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R3VlcmluLCBD

LjwvYXV0aG9yPjxhdXRob3I+Qm91cmRpbiwgRy48L2F1dGhvcj48YXV0aG9yPkxlcmF5LCBWLjwv

YXV0aG9yPjxhdXRob3I+RGVsYW5ub3ksIEIuPC9hdXRob3I+PGF1dGhvcj5CYXlsZSwgRi48L2F1

dGhvcj48YXV0aG9yPkdlcm1haW4sIE0uPC9hdXRob3I+PGF1dGhvcj5SaWNoYXJkLCBKLiBDLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNlcnZpY2UgZGUg

UmVhbmltYXRpb24gTWVkaWNhbGUgZXQgZCZhcG9zO0Fzc2lzdGFuY2UgUmVzcGlyYXRvaXJlLCBI

b3BpdGFsIGRlIGxhIENyb2l4IFJvdXNzZSwgTHlvbiwgRnJhbmNlLiBjbGF1ZGUuZ3VlcmluQGNo

dS1seW9uLmZyPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGVyZm9ybWFuY2Ugb2YgdGhl

IGNvdWdoYXNzaXN0IGluc3VmZmxhdGlvbi1leHN1ZmZsYXRpb24gZGV2aWNlIGluIHRoZSBwcmVz

ZW5jZSBvZiBhbiBlbmRvdHJhY2hlYWwgdHViZSBvciB0cmFjaGVvc3RvbXkgdHViZTogYSBiZW5j

aCBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5SZXNwaXIgQ2FyZTwvc2Vjb25kYXJ5LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlJlc3BpciBDYXJlPC9mdWxsLXRp

dGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTEwOC0xNDwvcGFnZXM+PHZvbHVtZT41Njwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Db3VnaC9waHlzaW9wYXRob2xv

Z3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+RXF1aXBtZW50IERlc2lnbjwva2V5d29yZD48

a2V5d29yZD5FeGhhbGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkZvcmNlZCBFeHBpcmF0b3J5IEZs

b3cgUmF0ZXMvcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW5zdWZmbGF0aW9uLyppbnN0cnVtZW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SW50

dWJhdGlvbiwgSW50cmF0cmFjaGVhbC8qaW5zdHJ1bWVudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

PlBoeXNpY2FsIFRoZXJhcHkgTW9kYWxpdGllcy8qaW5zdHJ1bWVudGF0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPlJlc3BpcmF0aW9uLCBBcnRpZmljaWFsLyppbnN0cnVtZW50YXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+UmVzcGlyYXRvcnkgSW5zdWZmaWNpZW5jeS9waHlzaW9wYXRob2xvZ3kvKnRoZXJh

cHk8L2tleXdvcmQ+PGtleXdvcmQ+VHJhY2hlb3N0b215LyppbnN0cnVtZW50YXRpb248L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1

ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjAtMTMyNCAoUHJpbnQpJiN4RDsw

MDIwLTEzMjQgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxODAxNTc3PC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5n

b3YvcHVibWVkLzIxODAxNTc3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC40MTg3L3Jlc3BjYXJlLjAxMTIxPC9lbGVjdHJvbmljLXJlc291cmNl

LW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 3,8 as required (see Clinical Guideline: Physiotherapy – Adult patient with a spinal cord injury, on the policy register, attachment 5 for details on how to perform Manual Assisted Cough). Alert: If the foot pedal on the Philips Respironics machine is plugged into the machine the manual lever will be disabled.After a treatment cycle, disconnect the patient from the device (return the patient back to the ventilator, if applicable). Allow time for a normal breathing pattern to return (20 to 30 seconds) to prevent hyperventilation. Alert: The unit Emerson CA-3200 cough assist is designed for Intermittent Operation Only and not for continuous use i.e. not cycled continuously for more than 5 minutes.Clear secretions that may have become visible in the mouth, throat or tracheostomy tube using tissues or suction (e.g. Yankauer, Y- catheter or closed suction system). For sputum clearance, continue sets until outcome measures indicate that sputum has been cleared. If you believe that the treatment is not adequate discuss immediately with the treating team. Perform hand hygiene. Document patient position, mode of delivery, pressure, dosage, outcome measures and ongoing management plan. Alert: Patients who are receiving this treatment may strain a muscle and can complain of soreness or discomfort post therapy. If this is the case, refer to the medical team for review. Treatment may need to be ceased it the pain is too severe.Cleaning and Maintenance ADDIN EN.CITE <EndNote><Cite><RecNum>1221</RecNum><DisplayText><style face="superscript">7</style></DisplayText><record><rec-number>1221</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503635515">1221</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Emerson 3200 User Manual</title></titles><dates></dates><urls><related-urls><url> mask and tubing require cleaning. The bacterial filter can be left in place as long as it is not blocked by sputum or trapped moisture. If it is soiled it will need to be replaced. Replace the mask, tubing and filter when there are obvious signs of wear and tear. The mask can also be replaced when it is no longer possible to get a good seal.Daily Cleaning:Wipe down the interface with a clean detergent wipe. If the circuit is visibly soiled (for example, with sputum), wash the tubing as per the instructions below.Weekly Cleaning:Wash the tubing and mask in warm soapy water and allow to air dry. The mask can be left to dry in the patient’s room on a clean towel. The tubing should be left to dry in a hanging position and must be completely dry before re-use.After final use by the patient, the circuit consisting of tubing, patient interface, adapters and bacterial/viral filter is disposed of. The patient circuit cannot be sterilised for reuse.If the device is to be used by more than one patient concurrently, the circuit including the tubing, patient interface, adapters and bacterial/viral filter must be replaced between patients to prevent cross contamination. The exterior of the machine is to be wiped down with a mild detergent and water, detergent wipes or with a bactericidal cleaning solution such as 70% isopropyl alcohol. Back to Table of Contents Section 2 – Inspiratory Muscle Training Inspiratory muscle training (IMT) increases the strength and endurance of the inspiratory muscles (diaphragm and accessory muscles). This treatment is relevant to 3 main groups of patients at CHHS:Chronic Obstructive Pulmonary Disease (COPD)Chronic Heart Failure (CHF)Intensive Care patients who have been mechanically ventilated for > 7 days.This section provides guidelines for IMT to assist patients to:Increase inspiratory muscle strength and enduranceFacilitate weaning from mechanical ventilation (Intensive Care Unit (ICU) patients)Improve patient quality of lifeReduce dyspnoeaImprove exercise tolerance.BackgroundIMT has been shown to improve respiratory muscle strength, endurance, exercise performance and quality of life, and reduce dyspnoea, in individuals with inspiratory muscle weakness and poor exercise tolerance (e.g. COPD ADDIN EN.CITE <EndNote><Cite><Author>Shoemaker</Author><Year>2009</Year><RecNum>10</RecNum><DisplayText><style face="superscript">9</style></DisplayText><record><rec-number>10</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1285416116">10</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shoemaker, M. J.</author><author>Donker, S.</author><author>Lapoe, A.</author></authors></contributors><auth-address>Grand Valley State University, Physical Therapy Program, Grand Rapids, MI.</auth-address><titles><title>Inspiratory muscle training in patients with chronic obstructive pulmonary disease: the state of the evidence</title><secondary-title>Cardiopulm Phys Ther J</secondary-title></titles><periodical><full-title>Cardiopulm Phys Ther J</full-title></periodical><pages>5-15</pages><volume>20</volume><number>3</number><edition>2010/05/15</edition><dates><year>2009</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1541-7891 (Print)&#xD;1541-7891 (Linking)</isbn><accession-num>20467518</accession-num><urls><related-urls><url>, CHFPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYWxsJmFwb3M7QWdvPC9BdXRob3I+PFllYXI+MjAwNjwv

WWVhcj48UmVjTnVtPjEzNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJz

Y3JpcHQiPjEwPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTM2PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjll

d3NlcnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjEyODU1MDg3NjQiPjEzNjwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RGFsbCZhcG9zO0FnbywgUC48L2F1

dGhvcj48YXV0aG9yPkNoaWFwcGEsIEcuIFIuPC9hdXRob3I+PGF1dGhvcj5HdXRocywgSC48L2F1

dGhvcj48YXV0aG9yPlN0ZWluLCBSLjwvYXV0aG9yPjxhdXRob3I+UmliZWlybywgSi4gUC48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m

IFBoeXNpb2xvZ2ljYWwgU2NpZW5jZXMsIEZ1bmRhY2FvIEZhY3VsZGFkZSBGZWRlcmFsIGRlIENp

ZW5jaWFzIE1lZGljYXMgZGUgUG9ydG8gQWxlZ3JlLCBQb3J0byBBbGVncmUsIEJyYXppbC48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNwaXJhdG9yeSBtdXNjbGUgdHJhaW5pbmcgaW4g

cGF0aWVudHMgd2l0aCBoZWFydCBmYWlsdXJlIGFuZCBpbnNwaXJhdG9yeSBtdXNjbGUgd2Vha25l

c3M6IGEgcmFuZG9taXplZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEFtIENvbGwg

Q2FyZGlvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkogQW0gQ29sbCBDYXJkaW9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NzU3LTYz

PC9wYWdlcz48dm9sdW1lPjQ3PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGVkaXRpb24+MjAw

Ni8wMi8yMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+KkJyZWF0aGluZyBFeGVyY2lzZXM8

L2tleXdvcmQ+PGtleXdvcmQ+RXhlcmNpc2UgVGVzdDwva2V5d29yZD48a2V5d29yZD5FeGVyY2lz

ZSBUb2xlcmFuY2U8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhl

YXJ0IEZhaWx1cmUvKmNvbXBsaWNhdGlvbnMvcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5oYWxhdGlvbjwva2V5d29yZD48a2V5d29y

ZD5JbnNwaXJhdG9yeSBDYXBhY2l0eTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk11c2NsZSBXZWFrbmVzcy9ldGlv

bG9neS9waHlzaW9wYXRob2xvZ3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPk94

eWdlbiBDb25zdW1wdGlvbjwva2V5d29yZD48a2V5d29yZD5RdWFsaXR5IG9mIExpZmU8L2tleXdv

cmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgTXVzY2xlcy8qcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3Jk

PjxrZXl3b3JkPldhbGtpbmc8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNjwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAyMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxp

c2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5NyAoTGlua2luZyk8L2lzYm4+

PGFjY2Vzc2lvbi1udW0+MTY0ODc4NDE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJs

cz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTY0ODc4NDE8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPlMwNzM1LTEwOTco

MDUpMDI3ODQtMSBbcGlpXSYjeEQ7MTAuMTAxNi9qLmphY2MuMjAwNS4wOS4wNTI8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48

L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYWxsJmFwb3M7QWdvPC9BdXRob3I+PFllYXI+MjAwNjwv

WWVhcj48UmVjTnVtPjEzNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJz

Y3JpcHQiPjEwPC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTM2PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjll

d3NlcnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjEyODU1MDg3NjQiPjEzNjwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RGFsbCZhcG9zO0FnbywgUC48L2F1

dGhvcj48YXV0aG9yPkNoaWFwcGEsIEcuIFIuPC9hdXRob3I+PGF1dGhvcj5HdXRocywgSC48L2F1

dGhvcj48YXV0aG9yPlN0ZWluLCBSLjwvYXV0aG9yPjxhdXRob3I+UmliZWlybywgSi4gUC48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m

IFBoeXNpb2xvZ2ljYWwgU2NpZW5jZXMsIEZ1bmRhY2FvIEZhY3VsZGFkZSBGZWRlcmFsIGRlIENp

ZW5jaWFzIE1lZGljYXMgZGUgUG9ydG8gQWxlZ3JlLCBQb3J0byBBbGVncmUsIEJyYXppbC48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNwaXJhdG9yeSBtdXNjbGUgdHJhaW5pbmcgaW4g

cGF0aWVudHMgd2l0aCBoZWFydCBmYWlsdXJlIGFuZCBpbnNwaXJhdG9yeSBtdXNjbGUgd2Vha25l

c3M6IGEgcmFuZG9taXplZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEFtIENvbGwg

Q2FyZGlvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkogQW0gQ29sbCBDYXJkaW9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NzU3LTYz

PC9wYWdlcz48dm9sdW1lPjQ3PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGVkaXRpb24+MjAw

Ni8wMi8yMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+KkJyZWF0aGluZyBFeGVyY2lzZXM8

L2tleXdvcmQ+PGtleXdvcmQ+RXhlcmNpc2UgVGVzdDwva2V5d29yZD48a2V5d29yZD5FeGVyY2lz

ZSBUb2xlcmFuY2U8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhl

YXJ0IEZhaWx1cmUvKmNvbXBsaWNhdGlvbnMvcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5oYWxhdGlvbjwva2V5d29yZD48a2V5d29y

ZD5JbnNwaXJhdG9yeSBDYXBhY2l0eTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk11c2NsZSBXZWFrbmVzcy9ldGlv

bG9neS9waHlzaW9wYXRob2xvZ3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPk94

eWdlbiBDb25zdW1wdGlvbjwva2V5d29yZD48a2V5d29yZD5RdWFsaXR5IG9mIExpZmU8L2tleXdv

cmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgTXVzY2xlcy8qcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3Jk

PjxrZXl3b3JkPldhbGtpbmc8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNjwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAyMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxp

c2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5NyAoTGlua2luZyk8L2lzYm4+

PGFjY2Vzc2lvbi1udW0+MTY0ODc4NDE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJs

cz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTY0ODc4NDE8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPlMwNzM1LTEwOTco

MDUpMDI3ODQtMSBbcGlpXSYjeEQ7MTAuMTAxNi9qLmphY2MuMjAwNS4wOS4wNTI8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48

L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA 10). IMT has also been shown to reduce length of weaning and increase muscle strength in ventilated patients ADDIN EN.CITE <EndNote><Cite><Author>Cader</Author><Year>2010</Year><RecNum>242</RecNum><DisplayText><style face="superscript">11</style></DisplayText><record><rec-number>242</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1286926067">242</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cader, S. A.</author><author>Vale, R. G.</author><author>Castro, J. C.</author><author>Bacelar, S. C.</author><author>Biehl, C.</author><author>Gomes, M. C.</author><author>Cabrer, W. E.</author><author>Dantas, E. H.</author></authors></contributors><auth-address>University Federal do Estada do Rio de Janiero - LABIMH-UNIRIO, Brazil. samariacader@</auth-address><titles><title>Inspiratory muscle training improves maximal inspiratory pressure and may assist weaning in older intubated patients: a randomised trial</title><secondary-title>J Physiother</secondary-title></titles><periodical><full-title>J Physiother</full-title></periodical><pages>171-7</pages><volume>56</volume><number>3</number><edition>2010/08/28</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Inhalation/*physiology</keyword><keyword>*Intubation, Intratracheal</keyword><keyword>Kaplan-Meiers Estimate</keyword><keyword>Male</keyword><keyword>Outcome Assessment (Health Care)</keyword><keyword>*Physical Therapy Modalities</keyword><keyword>Respiration</keyword><keyword>Respiration, Artificial</keyword><keyword>Respiratory Insufficiency/physiopathology/*therapy</keyword><keyword>Respiratory Muscles/*physiopathology</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword><keyword>*Ventilator Weaning</keyword></keywords><dates><year>2010</year></dates><isbn>1836-9553 (Print)</isbn><accession-num>20795923</accession-num><urls><related-urls><url>, and improve quality of life in patients recently weaned from prolonged mechanical ventilationPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaXNzZXR0PC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjEyMTM8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4xMjwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEyMTM8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzOXh3emR2cG4yOWV3c2Vy

dGFwNXd2ZGI5OWZyZWQ1cDIwMHYiIHRpbWVzdGFtcD0iMTQ5MDA0ODk5MyI+MTIxMzwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Qmlzc2V0dCwgQi4gTS48L2F1dGhvcj48

YXV0aG9yPkxlZGl0c2Noa2UsIEkuIEEuPC9hdXRob3I+PGF1dGhvcj5OZWVtYW4sIFQuPC9hdXRo

b3I+PGF1dGhvcj5Cb290cywgUi48L2F1dGhvcj48YXV0aG9yPlBhcmF0eiwgSi48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wgb2YgTWVkaWNpbmUs

IFVuaXZlcnNpdHkgb2YgUXVlZW5zbGFuZCwgQnJpc2JhbmUsIFF1ZWVuc2xhbmQsIEF1c3RyYWxp

YSBEaXNjaXBsaW5lIG9mIFBoeXNpb3RoZXJhcHksIFVuaXZlcnNpdHkgb2YgQ2FuYmVycmEsIEF1

c3RyYWxpYSBQaHlzaW90aGVyYXB5IERlcGFydG1lbnQsIENhbmJlcnJhIEhvc3BpdGFsLCBDYW5i

ZXJyYSwgQXVzdHJhbGlhbiBDYXBpdGFsIFRlcnJpdG9yeSwgQXVzdHJhbGlhLiYjeEQ7SW50ZW5z

aXZlIENhcmUgVW5pdCwgQ2FuYmVycmEgSG9zcGl0YWwsIENhbmJlcnJhLCBBdXN0cmFsaWFuIENh

cGl0YWwgVGVycml0b3J5LCBBdXN0cmFsaWEgSW50ZW5zaXZlIENhcmUgVW5pdCwgTWF0ZXIgSG9z

cGl0YWwsIEJyaXNiYW5lLCBRdWVlbnNsYW5kLCBBdXN0cmFsaWEgU2Nob29sIG9mIE1lZGljaW5l

LCBBdXN0cmFsaWFuIE5hdGlvbmFsIFVuaXZlcnNpdHksIENhbmJlcnJhLCBBdXN0cmFsaWFuIENh

cGl0YWwgVGVycml0b3J5LCBBdXN0cmFsaWEuJiN4RDtTdGF0aXN0aWNhbCBDb25zdWx0aW5nIFVu

aXQsIEF1c3RyYWxpYW4gTmF0aW9uYWwgVW5pdmVyc2l0eSwgQ2FuYmVycmEsIEF1c3RyYWxpYW4g

Q2FwaXRhbCBUZXJyaXRvcnksIEF1c3RyYWxpYS4mI3hEO1NjaG9vbCBvZiBNZWRpY2luZSwgVW5p

dmVyc2l0eSBvZiBRdWVlbnNsYW5kLCBCcmlzYmFuZSwgUXVlZW5zbGFuZCwgQXVzdHJhbGlhIElu

dGVuc2l2ZSBDYXJlIFVuaXQsIFJveWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0

YWwsIEhlcnN0b24sIFF1ZWVuc2xhbmQsIEF1c3RyYWxpYS4mI3hEO1NjaG9vbCBvZiBNZWRpY2lu

ZSwgVW5pdmVyc2l0eSBvZiBRdWVlbnNsYW5kLCBCcmlzYmFuZSwgUXVlZW5zbGFuZCwgQXVzdHJh

bGlhIEludGVuc2l2ZSBDYXJlIFVuaXQsIFJveWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3Mg

SG9zcGl0YWwsIEhlcnN0b24sIFF1ZWVuc2xhbmQsIEF1c3RyYWxpYSBTY2hvb2wgb2YgQWxsbGll

ZCBIZWFsdGggU2NpZW5jZXMsIEdyaWZmaXRoIFVuaXZlcnNpdHksIEF1c3RyYWxpYS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNwaXJhdG9yeSBtdXNjbGUgdHJhaW5pbmcgdG8gZW5o

YW5jZSByZWNvdmVyeSBmcm9tIG1lY2hhbmljYWwgdmVudGlsYXRpb246IGEgcmFuZG9taXNlZCB0

cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaG9yYXg8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UaG9yYXg8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz44MTItOTwvcGFnZXM+PHZvbHVtZT43MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVt

YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5FeGVyY2lzZTwva2V5d29yZD48a2V5d29yZD5SZXNwaXJh

dG9yeSBNZWFzdXJlbWVudDwva2V5d29yZD48a2V5d29yZD5SZXNwaXJhdG9yeSBNdXNjbGVzPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDY4LTMyOTYgKEVsZWN0cm9u

aWMpJiN4RDswMDQwLTYzNzYgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI3MjU3MDAz

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmku

bmxtLm5paC5nb3YvcHVibWVkLzI3MjU3MDAzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxj

dXN0b20yPlBNQzUwMTMwODg8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEx

MzYvdGhvcmF4am5sLTIwMTYtMjA4Mjc5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaXNzZXR0PC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjEyMTM8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4xMjwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEyMTM8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzOXh3emR2cG4yOWV3c2Vy

dGFwNXd2ZGI5OWZyZWQ1cDIwMHYiIHRpbWVzdGFtcD0iMTQ5MDA0ODk5MyI+MTIxMzwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Qmlzc2V0dCwgQi4gTS48L2F1dGhvcj48

YXV0aG9yPkxlZGl0c2Noa2UsIEkuIEEuPC9hdXRob3I+PGF1dGhvcj5OZWVtYW4sIFQuPC9hdXRo

b3I+PGF1dGhvcj5Cb290cywgUi48L2F1dGhvcj48YXV0aG9yPlBhcmF0eiwgSi48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wgb2YgTWVkaWNpbmUs

IFVuaXZlcnNpdHkgb2YgUXVlZW5zbGFuZCwgQnJpc2JhbmUsIFF1ZWVuc2xhbmQsIEF1c3RyYWxp

YSBEaXNjaXBsaW5lIG9mIFBoeXNpb3RoZXJhcHksIFVuaXZlcnNpdHkgb2YgQ2FuYmVycmEsIEF1

c3RyYWxpYSBQaHlzaW90aGVyYXB5IERlcGFydG1lbnQsIENhbmJlcnJhIEhvc3BpdGFsLCBDYW5i

ZXJyYSwgQXVzdHJhbGlhbiBDYXBpdGFsIFRlcnJpdG9yeSwgQXVzdHJhbGlhLiYjeEQ7SW50ZW5z

aXZlIENhcmUgVW5pdCwgQ2FuYmVycmEgSG9zcGl0YWwsIENhbmJlcnJhLCBBdXN0cmFsaWFuIENh

cGl0YWwgVGVycml0b3J5LCBBdXN0cmFsaWEgSW50ZW5zaXZlIENhcmUgVW5pdCwgTWF0ZXIgSG9z

cGl0YWwsIEJyaXNiYW5lLCBRdWVlbnNsYW5kLCBBdXN0cmFsaWEgU2Nob29sIG9mIE1lZGljaW5l

LCBBdXN0cmFsaWFuIE5hdGlvbmFsIFVuaXZlcnNpdHksIENhbmJlcnJhLCBBdXN0cmFsaWFuIENh

cGl0YWwgVGVycml0b3J5LCBBdXN0cmFsaWEuJiN4RDtTdGF0aXN0aWNhbCBDb25zdWx0aW5nIFVu

aXQsIEF1c3RyYWxpYW4gTmF0aW9uYWwgVW5pdmVyc2l0eSwgQ2FuYmVycmEsIEF1c3RyYWxpYW4g

Q2FwaXRhbCBUZXJyaXRvcnksIEF1c3RyYWxpYS4mI3hEO1NjaG9vbCBvZiBNZWRpY2luZSwgVW5p

dmVyc2l0eSBvZiBRdWVlbnNsYW5kLCBCcmlzYmFuZSwgUXVlZW5zbGFuZCwgQXVzdHJhbGlhIElu

dGVuc2l2ZSBDYXJlIFVuaXQsIFJveWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0

YWwsIEhlcnN0b24sIFF1ZWVuc2xhbmQsIEF1c3RyYWxpYS4mI3hEO1NjaG9vbCBvZiBNZWRpY2lu

ZSwgVW5pdmVyc2l0eSBvZiBRdWVlbnNsYW5kLCBCcmlzYmFuZSwgUXVlZW5zbGFuZCwgQXVzdHJh

bGlhIEludGVuc2l2ZSBDYXJlIFVuaXQsIFJveWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3Mg

SG9zcGl0YWwsIEhlcnN0b24sIFF1ZWVuc2xhbmQsIEF1c3RyYWxpYSBTY2hvb2wgb2YgQWxsbGll

ZCBIZWFsdGggU2NpZW5jZXMsIEdyaWZmaXRoIFVuaXZlcnNpdHksIEF1c3RyYWxpYS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNwaXJhdG9yeSBtdXNjbGUgdHJhaW5pbmcgdG8gZW5o

YW5jZSByZWNvdmVyeSBmcm9tIG1lY2hhbmljYWwgdmVudGlsYXRpb246IGEgcmFuZG9taXNlZCB0

cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaG9yYXg8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UaG9yYXg8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz44MTItOTwvcGFnZXM+PHZvbHVtZT43MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVt

YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5FeGVyY2lzZTwva2V5d29yZD48a2V5d29yZD5SZXNwaXJh

dG9yeSBNZWFzdXJlbWVudDwva2V5d29yZD48a2V5d29yZD5SZXNwaXJhdG9yeSBNdXNjbGVzPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDY4LTMyOTYgKEVsZWN0cm9u

aWMpJiN4RDswMDQwLTYzNzYgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI3MjU3MDAz

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmku

bmxtLm5paC5nb3YvcHVibWVkLzI3MjU3MDAzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxj

dXN0b20yPlBNQzUwMTMwODg8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEx

MzYvdGhvcmF4am5sLTIwMTYtMjA4Mjc5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 12. IMT is safe to perform in selected ventilated patients ADDIN EN.CITE <EndNote><Cite><Author>Bissett</Author><Year>2010</Year><RecNum>157</RecNum><DisplayText><style face="superscript">13</style></DisplayText><record><rec-number>157</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v">157</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bissett, B. Green, M. Leditschke, IA.</author></authors></contributors><titles><title>Inspiratory muscle training is safe in selected ventilated patients: a case series.</title><secondary-title>in preparation</secondary-title></titles><periodical><full-title>in preparation</full-title></periodical><dates><year>2010</year></dates><urls></urls></record></Cite></EndNote>13. High intensity, interval IMT programs are ideal for improving inspiratory muscle strength within just a few weeksPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IaWxsPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj

TnVtPjM1MDwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQiPjE0

PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MzUwPC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3NlcnRhcDV3

dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjEyODg1MjM5MTIiPjM1MDwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SGlsbCwgSy48L2F1dGhvcj48YXV0aG9yPkplbmtp

bnMsIFMuIEMuPC9hdXRob3I+PGF1dGhvcj5QaGlsaXBwZSwgRC4gTC48L2F1dGhvcj48YXV0aG9y

PkNlY2lucywgTi48L2F1dGhvcj48YXV0aG9yPlNoZXBoZXJkLCBLLiBMLjwvYXV0aG9yPjxhdXRo

b3I+R3JlZW4sIEQuIEouPC9hdXRob3I+PGF1dGhvcj5IaWxsbWFuLCBELiBSLjwvYXV0aG9yPjxh

dXRob3I+RWFzdHdvb2QsIFAuIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+RGVwdCBvZiBQdWxtb25hcnkgUGh5c2lvbG9neSwgU2lyIENoYXJsZXMgR2Fp

cmRuZXIgSG9zcGl0YWwsIEhvc3BpdGFsIEF2ZW51ZSwgTmVkbGFuZHMsIFdlc3Rlcm4gQXVzdHJh

bGlhLCA2MDA5IEF1c3RyYWxpYS4gcGV0ZXIuZWFzdHdvb2RAaGVhbHRoLndhLmdvdi5hdTwvYXV0

aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkhpZ2gtaW50ZW5zaXR5IGluc3BpcmF0b3J5IG11c2Ns

ZSB0cmFpbmluZyBpbiBDT1BEPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBSZXNwaXIgSjwv

c2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1ciBSZXNw

aXIgSjwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjExMTktMjg8L3BhZ2VzPjx2b2x1

bWU+Mjc8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4yMDA2LzA2LzE1PC9lZGl0

aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkRvdWJsZS1CbGlu

ZCBNZXRob2Q8L2tleXdvcmQ+PGtleXdvcmQ+RHlzcG5lYS9waHlzaW9wYXRob2xvZ3kvcmVoYWJp

bGl0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RXhlcmNpc2UvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+RmF0aWd1ZS9waHlzaW9wYXRob2xvZ3kvcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD5JbmhhbGF0aW9uL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SW5zcGlyYXRvcnkgQ2Fw

YWNpdHkvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29y

ZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QaHlzaWNhbCBFbmR1cmFuY2UvcGh5c2lv

bG9neTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3

b3JkPlB1bG1vbmFyeSBEaXNlYXNlLCBDaHJvbmljIE9ic3RydWN0aXZlL3BoeXNpb3BhdGhvbG9n

eS8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlPC9rZXl3

b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IE11c2NsZXMvKnBoeXNpb3BhdGhvbG9neTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVu

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDkwMy0xOTM2IChQcmludCkmI3hEOzA5

MDMtMTkzNiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTY3NzIzODg8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTY3NzIzODg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjI3LzYvMTExOSBbcGlpXSYjeEQ7MTAuMTE4My8wOTAzMTkzNi4wNi4wMDEw

NTIwNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9y

ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IaWxsPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj

TnVtPjM1MDwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQiPjE0

PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MzUwPC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3NlcnRhcDV3

dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjEyODg1MjM5MTIiPjM1MDwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SGlsbCwgSy48L2F1dGhvcj48YXV0aG9yPkplbmtp

bnMsIFMuIEMuPC9hdXRob3I+PGF1dGhvcj5QaGlsaXBwZSwgRC4gTC48L2F1dGhvcj48YXV0aG9y

PkNlY2lucywgTi48L2F1dGhvcj48YXV0aG9yPlNoZXBoZXJkLCBLLiBMLjwvYXV0aG9yPjxhdXRo

b3I+R3JlZW4sIEQuIEouPC9hdXRob3I+PGF1dGhvcj5IaWxsbWFuLCBELiBSLjwvYXV0aG9yPjxh

dXRob3I+RWFzdHdvb2QsIFAuIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+RGVwdCBvZiBQdWxtb25hcnkgUGh5c2lvbG9neSwgU2lyIENoYXJsZXMgR2Fp

cmRuZXIgSG9zcGl0YWwsIEhvc3BpdGFsIEF2ZW51ZSwgTmVkbGFuZHMsIFdlc3Rlcm4gQXVzdHJh

bGlhLCA2MDA5IEF1c3RyYWxpYS4gcGV0ZXIuZWFzdHdvb2RAaGVhbHRoLndhLmdvdi5hdTwvYXV0

aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkhpZ2gtaW50ZW5zaXR5IGluc3BpcmF0b3J5IG11c2Ns

ZSB0cmFpbmluZyBpbiBDT1BEPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBSZXNwaXIgSjwv

c2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1ciBSZXNw

aXIgSjwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjExMTktMjg8L3BhZ2VzPjx2b2x1

bWU+Mjc8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4yMDA2LzA2LzE1PC9lZGl0

aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkRvdWJsZS1CbGlu

ZCBNZXRob2Q8L2tleXdvcmQ+PGtleXdvcmQ+RHlzcG5lYS9waHlzaW9wYXRob2xvZ3kvcmVoYWJp

bGl0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RXhlcmNpc2UvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+RmF0aWd1ZS9waHlzaW9wYXRob2xvZ3kvcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD5JbmhhbGF0aW9uL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SW5zcGlyYXRvcnkgQ2Fw

YWNpdHkvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29y

ZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QaHlzaWNhbCBFbmR1cmFuY2UvcGh5c2lv

bG9neTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3

b3JkPlB1bG1vbmFyeSBEaXNlYXNlLCBDaHJvbmljIE9ic3RydWN0aXZlL3BoeXNpb3BhdGhvbG9n

eS8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlPC9rZXl3

b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IE11c2NsZXMvKnBoeXNpb3BhdGhvbG9neTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVu

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDkwMy0xOTM2IChQcmludCkmI3hEOzA5

MDMtMTkzNiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTY3NzIzODg8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTY3NzIzODg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjI3LzYvMTExOSBbcGlpXSYjeEQ7MTAuMTE4My8wOTAzMTkzNi4wNi4wMDEw

NTIwNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9y

ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA 14, with significant changes detectable as early as 2 weeks of trainingPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc29uPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48

UmVjTnVtPjI3ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjE1LDE2PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+Mjc4PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3Nl

cnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjEyODg1MTk2MDQiPjI3ODwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Sm9obnNvbiwgTS4gQS48L2F1dGhvcj48

YXV0aG9yPlNoYXJwZSwgRy4gUi48L2F1dGhvcj48YXV0aG9yPkJyb3duLCBQLiBJLjwvYXV0aG9y

PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNjaG9vbCBvZiBTY2llbmNl

IGFuZCBUZWNobm9sb2d5LCBOb3R0aW5naGFtIFRyZW50IFVuaXZlcnNpdHksIE5vdHRpbmdoYW0s

IE5HMTEgOE5TLCBVSy4gbWljaGFlbC5qb2huc29uQG50dS5hYy51azwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPkluc3BpcmF0b3J5IG11c2NsZSB0cmFpbmluZyBpbXByb3ZlcyBjeWNsaW5n

IHRpbWUtdHJpYWwgcGVyZm9ybWFuY2UgYW5kIGFuYWVyb2JpYyB3b3JrIGNhcGFjaXR5IGJ1dCBu

b3QgY3JpdGljYWwgcG93ZXI8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEogQXBwbCBQaHlz

aW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+RXVy

IEogQXBwbCBQaHlzaW9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NzYxLTcwPC9w

YWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxlZGl0aW9uPjIwMDcv

MDkvMTg8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFuYWVyb2JpYyBUaHJlc2hvbGQvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXRobGV0

aWMgUGVyZm9ybWFuY2UvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QmljeWNsaW5nLypw

aHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkV4ZXJjaXNlIFRlc3Q8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluc3BpcmF0b3J5IENhcGFjaXR5L3BoeXNpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5QaHlzaWNhbCBGaXRu

ZXNzLypwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IEZ1bmN0aW9uIFRl

c3RzPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IE11c2NsZXMvKnBoeXNpb2xvZ3k8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRl

PkRlYzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0MzktNjMxOSAoUHJpbnQpJiN4

RDsxNDM5LTYzMTkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3ODc0MTIzPC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p

aC5nb3YvcHVibWVkLzE3ODc0MTIzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDA3L3MwMDQyMS0wMDctMDU1MS0zPC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+

PEF1dGhvcj5DYWhhbGluPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVjTnVtPjQyMjwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NDIyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3NlcnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0

aW1lc3RhbXA9IjEyODg1MjM5MjIiPjQyMjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+Q2FoYWxpbiwgTC4gUC48L2F1dGhvcj48YXV0aG9yPlNlbWlncmFuLCBNLiBKLjwv

YXV0aG9yPjxhdXRob3I+RGVjLCBHLiBXLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkhlYXJ0IEZhaWx1cmUgYW5kIFRyYW5zcGxhbnRhdGlvbiBTZXJ2aWNl

LCBNYXNzYWNodXNldHRzIEdlbmVyYWwgSG9zcGl0YWwsIEJvc3RvbiwgVVNBLiBjYWhhbGlubEBi

dS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNwaXJhdG9yeSBtdXNjbGUgdHJh

aW5pbmcgaW4gcGF0aWVudHMgd2l0aCBjaHJvbmljIGhlYXJ0IGZhaWx1cmUgYXdhaXRpbmcgY2Fy

ZGlhYyB0cmFuc3BsYW50YXRpb246IHJlc3VsdHMgb2YgYSBwaWxvdCBjbGluaWNhbCB0cmlhbDwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5QaHlzIFRoZXI8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QaHlzIFRoZXI8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz44MzAtODwvcGFnZXM+PHZvbHVtZT43Nzwvdm9sdW1lPjxudW1iZXI+ODwvbnVt

YmVyPjxlZGl0aW9uPjE5OTcvMDgvMDE8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0

PC9rZXl3b3JkPjxrZXl3b3JkPipCcmVhdGhpbmcgRXhlcmNpc2VzPC9rZXl3b3JkPjxrZXl3b3Jk

PkNocm9uaWMgRGlzZWFzZTwva2V5d29yZD48a2V5d29yZD5EeXNwbmVhL2V0aW9sb2d5LypyZWhh

YmlsaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVh

cnQgRmFpbHVyZS8qY29tcGxpY2F0aW9ucy9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPipIZWFy

dCBUcmFuc3BsYW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWF4aW1hbCBWb2x1bnRhcnkgVmVudGlsYXRpb248

L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UGlsb3QgUHJv

amVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgTXVzY2xlczwva2V5d29yZD48a2V5

d29yZD5TZXZlcml0eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFj

dG9yczwva2V5d29yZD48a2V5d29yZD4qV2FpdGluZyBMaXN0czwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4xOTk3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzMS05MDIzIChQcmludCkmI3hEOzAwMzEtOTAyMyAoTGlu

a2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+OTI1Njg3MTwvYWNjZXNzaW9uLW51bT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85MjU2

ODcxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc29uPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48

UmVjTnVtPjI3ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjE1LDE2PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+Mjc4PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3Nl

cnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjEyODg1MTk2MDQiPjI3ODwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Sm9obnNvbiwgTS4gQS48L2F1dGhvcj48

YXV0aG9yPlNoYXJwZSwgRy4gUi48L2F1dGhvcj48YXV0aG9yPkJyb3duLCBQLiBJLjwvYXV0aG9y

PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNjaG9vbCBvZiBTY2llbmNl

IGFuZCBUZWNobm9sb2d5LCBOb3R0aW5naGFtIFRyZW50IFVuaXZlcnNpdHksIE5vdHRpbmdoYW0s

IE5HMTEgOE5TLCBVSy4gbWljaGFlbC5qb2huc29uQG50dS5hYy51azwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPkluc3BpcmF0b3J5IG11c2NsZSB0cmFpbmluZyBpbXByb3ZlcyBjeWNsaW5n

IHRpbWUtdHJpYWwgcGVyZm9ybWFuY2UgYW5kIGFuYWVyb2JpYyB3b3JrIGNhcGFjaXR5IGJ1dCBu

b3QgY3JpdGljYWwgcG93ZXI8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyIEogQXBwbCBQaHlz

aW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+RXVy

IEogQXBwbCBQaHlzaW9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NzYxLTcwPC9w

YWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxlZGl0aW9uPjIwMDcv

MDkvMTg8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFuYWVyb2JpYyBUaHJlc2hvbGQvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXRobGV0

aWMgUGVyZm9ybWFuY2UvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QmljeWNsaW5nLypw

aHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkV4ZXJjaXNlIFRlc3Q8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluc3BpcmF0b3J5IENhcGFjaXR5L3BoeXNpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5QaHlzaWNhbCBGaXRu

ZXNzLypwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IEZ1bmN0aW9uIFRl

c3RzPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IE11c2NsZXMvKnBoeXNpb2xvZ3k8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRl

PkRlYzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0MzktNjMxOSAoUHJpbnQpJiN4

RDsxNDM5LTYzMTkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3ODc0MTIzPC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p

aC5nb3YvcHVibWVkLzE3ODc0MTIzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDA3L3MwMDQyMS0wMDctMDU1MS0zPC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+

PEF1dGhvcj5DYWhhbGluPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVjTnVtPjQyMjwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NDIyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iczl4d3pkdnBuMjlld3NlcnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0

aW1lc3RhbXA9IjEyODg1MjM5MjIiPjQyMjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+Q2FoYWxpbiwgTC4gUC48L2F1dGhvcj48YXV0aG9yPlNlbWlncmFuLCBNLiBKLjwv

YXV0aG9yPjxhdXRob3I+RGVjLCBHLiBXLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkhlYXJ0IEZhaWx1cmUgYW5kIFRyYW5zcGxhbnRhdGlvbiBTZXJ2aWNl

LCBNYXNzYWNodXNldHRzIEdlbmVyYWwgSG9zcGl0YWwsIEJvc3RvbiwgVVNBLiBjYWhhbGlubEBi

dS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNwaXJhdG9yeSBtdXNjbGUgdHJh

aW5pbmcgaW4gcGF0aWVudHMgd2l0aCBjaHJvbmljIGhlYXJ0IGZhaWx1cmUgYXdhaXRpbmcgY2Fy

ZGlhYyB0cmFuc3BsYW50YXRpb246IHJlc3VsdHMgb2YgYSBwaWxvdCBjbGluaWNhbCB0cmlhbDwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5QaHlzIFRoZXI8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QaHlzIFRoZXI8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz44MzAtODwvcGFnZXM+PHZvbHVtZT43Nzwvdm9sdW1lPjxudW1iZXI+ODwvbnVt

YmVyPjxlZGl0aW9uPjE5OTcvMDgvMDE8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0

PC9rZXl3b3JkPjxrZXl3b3JkPipCcmVhdGhpbmcgRXhlcmNpc2VzPC9rZXl3b3JkPjxrZXl3b3Jk

PkNocm9uaWMgRGlzZWFzZTwva2V5d29yZD48a2V5d29yZD5EeXNwbmVhL2V0aW9sb2d5LypyZWhh

YmlsaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVh

cnQgRmFpbHVyZS8qY29tcGxpY2F0aW9ucy9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPipIZWFy

dCBUcmFuc3BsYW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWF4aW1hbCBWb2x1bnRhcnkgVmVudGlsYXRpb248

L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UGlsb3QgUHJv

amVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgTXVzY2xlczwva2V5d29yZD48a2V5

d29yZD5TZXZlcml0eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFj

dG9yczwva2V5d29yZD48a2V5d29yZD4qV2FpdGluZyBMaXN0czwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4xOTk3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzMS05MDIzIChQcmludCkmI3hEOzAwMzEtOTAyMyAoTGlu

a2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+OTI1Njg3MTwvYWNjZXNzaW9uLW51bT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85MjU2

ODcxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA 15,16. The ‘acute’ IMT protocol described in this guideline is based on a high-intensity, interval-based approach as described in several case seriesPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TcHJhZ3VlPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48

UmVjTnVtPjMwPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MTctMTk8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4zMDwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InM5eHd6ZHZwbjI5ZXdzZXJ0

YXA1d3ZkYjk5ZnJlZDVwMjAwdiIgdGltZXN0YW1wPSIxMjg1NDE3NjQ1Ij4zMDwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U3ByYWd1ZSwgUy4gUy48L2F1dGhvcj48YXV0

aG9yPkhvcGtpbnMsIFAuIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+c3NvY3JhdGVzc3ByYWd1ZUB5YWhvby5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5Vc2Ugb2YgaW5zcGlyYXRvcnkgc3RyZW5ndGggdHJhaW5pbmcgdG8gd2VhbiBzaXgg

cGF0aWVudHMgd2hvIHdlcmUgdmVudGlsYXRvci1kZXBlbmRlbnQ8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+UGh5cyBUaGVyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+UGh5cyBUaGVyPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTcxLTgx

PC9wYWdlcz48dm9sdW1lPjgzPC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAw

My8wMi8wNTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdv

cmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5EeXNwbmVhL3JlaGFiaWxpdGF0aW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPkV4ZXJjaXNlIFRoZXJhcHkvaW5zdHJ1bWVudGF0aW9uLyptZXRob2RzPC9rZXl3

b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW5zcGlyYXRvcnkgQ2FwYWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29y

ZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5SZXNwaXJhdG9yeSBNdXNj

bGVzPC9rZXl3b3JkPjxrZXl3b3JkPlZlbnRpbGF0b3IgV2VhbmluZy8qbWV0aG9kczwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmVi

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzMS05MDIzIChQcmludCkmI3hEOzAw

MzEtOTAyMyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTI1NjQ5NTI8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTI1NjQ5NTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGxhbmd1YWdlPmVu

ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWFydGluPC9BdXRob3I+

PFllYXI+MjAwMjwvWWVhcj48UmVjTnVtPjM5NTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+

Mzk1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pk

dnBuMjlld3NlcnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjEyODg1MjM5MTciPjM5

NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFydGluLCBBLiBELjwv

YXV0aG9yPjxhdXRob3I+RGF2ZW5wb3J0LCBQLiBELjwvYXV0aG9yPjxhdXRob3I+RnJhbmNlc2No

aSwgQS4gQy48L2F1dGhvcj48YXV0aG9yPkhhcm1hbiwgRS48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBoeXNpY2FsIFRoZXJhcHks

IFVuaXZlcnNpdHkgb2YgRmxvcmlkYSwgR2FpbmVzdmlsbGUsIEZMLCBVU0EuIGRtYXJ0aW5AaHAu

dWZsLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlVzZSBvZiBpbnNwaXJhdG9yeSBt

dXNjbGUgc3RyZW5ndGggdHJhaW5pbmcgdG8gZmFjaWxpdGF0ZSB2ZW50aWxhdG9yIHdlYW5pbmc6

IGEgc2VyaWVzIG9mIDEwIGNvbnNlY3V0aXZlIHBhdGllbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNoZXN0PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+Q2hlc3Q8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xOTItNjwvcGFnZXM+PHZv

bHVtZT4xMjI8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZWRpdGlvbj4yMDAyLzA3LzEzPC9l

ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9r

ZXl3b3JkPjxrZXl3b3JkPipCcmVhdGhpbmcgRXhlcmNpc2VzPC9rZXl3b3JkPjxrZXl3b3JkPkZl

bWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkludGVyY29z

dGFsIE11c2NsZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRk

bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD4qUmVzcGlyYXRpb24sIEFydGlmaWNpYWw8L2tleXdv

cmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgSW5zdWZmaWNpZW5jeS9ldGlvbG9neS8qdGhlcmFweTwv

a2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5WZW50

aWxhdG9yIFdlYW5pbmcvKm1ldGhvZHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjAwMTItMzY5MiAoUHJpbnQpJiN4RDswMDEyLTM2OTIgKExpbmtpbmcpPC9pc2JuPjxh

Y2Nlc3Npb24tbnVtPjEyMTE0MzU3PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzEyMTE0MzU3PC91cmw+PC9y

ZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPkJpc3NldHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxSZWNOdW0+

MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9InM5eHd6ZHZwbjI5ZXdzZXJ0YXA1d3ZkYjk5ZnJlZDVwMjAw

diIgdGltZXN0YW1wPSIxMjg1NDA4NzgyIj4xPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv

cnM+PGF1dGhvcj5CaXNzZXR0LCBCLjwvYXV0aG9yPjxhdXRob3I+TGVkaXRzY2hrZSwgSS4gQS48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbnRlbnNpdmUg

Q2FyZSBVbml0LCBUaGUgQ2FuYmVycmEgSG9zcGl0YWwsIEdhcnJhbiwgQXVzdHJhbGlhbiBDYXBp

dGFsIFRlcnJpdG9yeSwgQXVzdHJhbGlhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPklu

c3BpcmF0b3J5IG11c2NsZSB0cmFpbmluZyB0byBlbmhhbmNlIHdlYW5pbmcgZnJvbSBtZWNoYW5p

Y2FsIHZlbnRpbGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFuYWVzdGggSW50ZW5zaXZl

IENhcmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5B

bmFlc3RoIEludGVuc2l2ZSBDYXJlPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+Nzc2

LTk8L3BhZ2VzPjx2b2x1bWU+MzU8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJlcj48ZWRpdGlvbj4y

MDA3LzEwLzE2PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPipCcmVhdGhpbmcgRXhlcmNpc2VzPC9rZXl3b3JkPjxrZXl3b3JkPkVxdWlwbWVudCBEZXNp

Z248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+KlJlc3BpcmF0aW9uLCBBcnRpZmljaWFsPC9rZXl3b3JkPjxrZXl3b3JkPlJl

c3BpcmF0b3J5IEluc3VmZmljaWVuY3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

PlRpbWUgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5WZW50aWxhdG9yIFdlYW5pbmcvKm1ldGhv

ZHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVz

PjxkYXRlPk9jdDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAzMTAtMDU3WCAoUHJp

bnQpJiN4RDswMzEwLTA1N1ggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3OTMzMTY4

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmku

bmxtLm5paC5nb3YvcHVibWVkLzE3OTMzMTY4PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxs

YW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TcHJhZ3VlPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48

UmVjTnVtPjMwPC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+

MTctMTk8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4zMDwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InM5eHd6ZHZwbjI5ZXdzZXJ0

YXA1d3ZkYjk5ZnJlZDVwMjAwdiIgdGltZXN0YW1wPSIxMjg1NDE3NjQ1Ij4zMDwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U3ByYWd1ZSwgUy4gUy48L2F1dGhvcj48YXV0

aG9yPkhvcGtpbnMsIFAuIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+c3NvY3JhdGVzc3ByYWd1ZUB5YWhvby5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5Vc2Ugb2YgaW5zcGlyYXRvcnkgc3RyZW5ndGggdHJhaW5pbmcgdG8gd2VhbiBzaXgg

cGF0aWVudHMgd2hvIHdlcmUgdmVudGlsYXRvci1kZXBlbmRlbnQ8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+UGh5cyBUaGVyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+UGh5cyBUaGVyPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTcxLTgx

PC9wYWdlcz48dm9sdW1lPjgzPC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAw

My8wMi8wNTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdv

cmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5EeXNwbmVhL3JlaGFiaWxpdGF0aW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPkV4ZXJjaXNlIFRoZXJhcHkvaW5zdHJ1bWVudGF0aW9uLyptZXRob2RzPC9rZXl3

b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW5zcGlyYXRvcnkgQ2FwYWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29y

ZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5SZXNwaXJhdG9yeSBNdXNj

bGVzPC9rZXl3b3JkPjxrZXl3b3JkPlZlbnRpbGF0b3IgV2VhbmluZy8qbWV0aG9kczwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmVi

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzMS05MDIzIChQcmludCkmI3hEOzAw

MzEtOTAyMyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTI1NjQ5NTI8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTI1NjQ5NTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGxhbmd1YWdlPmVu

ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWFydGluPC9BdXRob3I+

PFllYXI+MjAwMjwvWWVhcj48UmVjTnVtPjM5NTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+

Mzk1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pk

dnBuMjlld3NlcnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjEyODg1MjM5MTciPjM5

NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFydGluLCBBLiBELjwv

YXV0aG9yPjxhdXRob3I+RGF2ZW5wb3J0LCBQLiBELjwvYXV0aG9yPjxhdXRob3I+RnJhbmNlc2No

aSwgQS4gQy48L2F1dGhvcj48YXV0aG9yPkhhcm1hbiwgRS48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBoeXNpY2FsIFRoZXJhcHks

IFVuaXZlcnNpdHkgb2YgRmxvcmlkYSwgR2FpbmVzdmlsbGUsIEZMLCBVU0EuIGRtYXJ0aW5AaHAu

dWZsLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlVzZSBvZiBpbnNwaXJhdG9yeSBt

dXNjbGUgc3RyZW5ndGggdHJhaW5pbmcgdG8gZmFjaWxpdGF0ZSB2ZW50aWxhdG9yIHdlYW5pbmc6

IGEgc2VyaWVzIG9mIDEwIGNvbnNlY3V0aXZlIHBhdGllbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNoZXN0PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+Q2hlc3Q8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xOTItNjwvcGFnZXM+PHZv

bHVtZT4xMjI8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZWRpdGlvbj4yMDAyLzA3LzEzPC9l

ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9r

ZXl3b3JkPjxrZXl3b3JkPipCcmVhdGhpbmcgRXhlcmNpc2VzPC9rZXl3b3JkPjxrZXl3b3JkPkZl

bWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkludGVyY29z

dGFsIE11c2NsZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRk

bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD4qUmVzcGlyYXRpb24sIEFydGlmaWNpYWw8L2tleXdv

cmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgSW5zdWZmaWNpZW5jeS9ldGlvbG9neS8qdGhlcmFweTwv

a2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5WZW50

aWxhdG9yIFdlYW5pbmcvKm1ldGhvZHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjAwMTItMzY5MiAoUHJpbnQpJiN4RDswMDEyLTM2OTIgKExpbmtpbmcpPC9pc2JuPjxh

Y2Nlc3Npb24tbnVtPjEyMTE0MzU3PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzEyMTE0MzU3PC91cmw+PC9y

ZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPkJpc3NldHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxSZWNOdW0+

MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9InM5eHd6ZHZwbjI5ZXdzZXJ0YXA1d3ZkYjk5ZnJlZDVwMjAw

diIgdGltZXN0YW1wPSIxMjg1NDA4NzgyIj4xPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv

cnM+PGF1dGhvcj5CaXNzZXR0LCBCLjwvYXV0aG9yPjxhdXRob3I+TGVkaXRzY2hrZSwgSS4gQS48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbnRlbnNpdmUg

Q2FyZSBVbml0LCBUaGUgQ2FuYmVycmEgSG9zcGl0YWwsIEdhcnJhbiwgQXVzdHJhbGlhbiBDYXBp

dGFsIFRlcnJpdG9yeSwgQXVzdHJhbGlhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPklu

c3BpcmF0b3J5IG11c2NsZSB0cmFpbmluZyB0byBlbmhhbmNlIHdlYW5pbmcgZnJvbSBtZWNoYW5p

Y2FsIHZlbnRpbGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFuYWVzdGggSW50ZW5zaXZl

IENhcmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5B

bmFlc3RoIEludGVuc2l2ZSBDYXJlPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+Nzc2

LTk8L3BhZ2VzPjx2b2x1bWU+MzU8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJlcj48ZWRpdGlvbj4y

MDA3LzEwLzE2PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPipCcmVhdGhpbmcgRXhlcmNpc2VzPC9rZXl3b3JkPjxrZXl3b3JkPkVxdWlwbWVudCBEZXNp

Z248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+KlJlc3BpcmF0aW9uLCBBcnRpZmljaWFsPC9rZXl3b3JkPjxrZXl3b3JkPlJl

c3BpcmF0b3J5IEluc3VmZmljaWVuY3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

PlRpbWUgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5WZW50aWxhdG9yIFdlYW5pbmcvKm1ldGhv

ZHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVz

PjxkYXRlPk9jdDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAzMTAtMDU3WCAoUHJp

bnQpJiN4RDswMzEwLTA1N1ggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3OTMzMTY4

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmku

bmxtLm5paC5nb3YvcHVibWVkLzE3OTMzMTY4PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxs

YW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA 17-19 and a good quality randomised trialPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaXNzZXR0PC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjEyMTM8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4xMjwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEyMTM8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzOXh3emR2cG4yOWV3c2Vy

dGFwNXd2ZGI5OWZyZWQ1cDIwMHYiIHRpbWVzdGFtcD0iMTQ5MDA0ODk5MyI+MTIxMzwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Qmlzc2V0dCwgQi4gTS48L2F1dGhvcj48

YXV0aG9yPkxlZGl0c2Noa2UsIEkuIEEuPC9hdXRob3I+PGF1dGhvcj5OZWVtYW4sIFQuPC9hdXRo

b3I+PGF1dGhvcj5Cb290cywgUi48L2F1dGhvcj48YXV0aG9yPlBhcmF0eiwgSi48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wgb2YgTWVkaWNpbmUs

IFVuaXZlcnNpdHkgb2YgUXVlZW5zbGFuZCwgQnJpc2JhbmUsIFF1ZWVuc2xhbmQsIEF1c3RyYWxp

YSBEaXNjaXBsaW5lIG9mIFBoeXNpb3RoZXJhcHksIFVuaXZlcnNpdHkgb2YgQ2FuYmVycmEsIEF1

c3RyYWxpYSBQaHlzaW90aGVyYXB5IERlcGFydG1lbnQsIENhbmJlcnJhIEhvc3BpdGFsLCBDYW5i

ZXJyYSwgQXVzdHJhbGlhbiBDYXBpdGFsIFRlcnJpdG9yeSwgQXVzdHJhbGlhLiYjeEQ7SW50ZW5z

aXZlIENhcmUgVW5pdCwgQ2FuYmVycmEgSG9zcGl0YWwsIENhbmJlcnJhLCBBdXN0cmFsaWFuIENh

cGl0YWwgVGVycml0b3J5LCBBdXN0cmFsaWEgSW50ZW5zaXZlIENhcmUgVW5pdCwgTWF0ZXIgSG9z

cGl0YWwsIEJyaXNiYW5lLCBRdWVlbnNsYW5kLCBBdXN0cmFsaWEgU2Nob29sIG9mIE1lZGljaW5l

LCBBdXN0cmFsaWFuIE5hdGlvbmFsIFVuaXZlcnNpdHksIENhbmJlcnJhLCBBdXN0cmFsaWFuIENh

cGl0YWwgVGVycml0b3J5LCBBdXN0cmFsaWEuJiN4RDtTdGF0aXN0aWNhbCBDb25zdWx0aW5nIFVu

aXQsIEF1c3RyYWxpYW4gTmF0aW9uYWwgVW5pdmVyc2l0eSwgQ2FuYmVycmEsIEF1c3RyYWxpYW4g

Q2FwaXRhbCBUZXJyaXRvcnksIEF1c3RyYWxpYS4mI3hEO1NjaG9vbCBvZiBNZWRpY2luZSwgVW5p

dmVyc2l0eSBvZiBRdWVlbnNsYW5kLCBCcmlzYmFuZSwgUXVlZW5zbGFuZCwgQXVzdHJhbGlhIElu

dGVuc2l2ZSBDYXJlIFVuaXQsIFJveWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0

YWwsIEhlcnN0b24sIFF1ZWVuc2xhbmQsIEF1c3RyYWxpYS4mI3hEO1NjaG9vbCBvZiBNZWRpY2lu

ZSwgVW5pdmVyc2l0eSBvZiBRdWVlbnNsYW5kLCBCcmlzYmFuZSwgUXVlZW5zbGFuZCwgQXVzdHJh

bGlhIEludGVuc2l2ZSBDYXJlIFVuaXQsIFJveWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3Mg

SG9zcGl0YWwsIEhlcnN0b24sIFF1ZWVuc2xhbmQsIEF1c3RyYWxpYSBTY2hvb2wgb2YgQWxsbGll

ZCBIZWFsdGggU2NpZW5jZXMsIEdyaWZmaXRoIFVuaXZlcnNpdHksIEF1c3RyYWxpYS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNwaXJhdG9yeSBtdXNjbGUgdHJhaW5pbmcgdG8gZW5o

YW5jZSByZWNvdmVyeSBmcm9tIG1lY2hhbmljYWwgdmVudGlsYXRpb246IGEgcmFuZG9taXNlZCB0

cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaG9yYXg8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UaG9yYXg8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz44MTItOTwvcGFnZXM+PHZvbHVtZT43MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVt

YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5FeGVyY2lzZTwva2V5d29yZD48a2V5d29yZD5SZXNwaXJh

dG9yeSBNZWFzdXJlbWVudDwva2V5d29yZD48a2V5d29yZD5SZXNwaXJhdG9yeSBNdXNjbGVzPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDY4LTMyOTYgKEVsZWN0cm9u

aWMpJiN4RDswMDQwLTYzNzYgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI3MjU3MDAz

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmku

bmxtLm5paC5nb3YvcHVibWVkLzI3MjU3MDAzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxj

dXN0b20yPlBNQzUwMTMwODg8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEx

MzYvdGhvcmF4am5sLTIwMTYtMjA4Mjc5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaXNzZXR0PC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjEyMTM8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0

Ij4xMjwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEyMTM8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzOXh3emR2cG4yOWV3c2Vy

dGFwNXd2ZGI5OWZyZWQ1cDIwMHYiIHRpbWVzdGFtcD0iMTQ5MDA0ODk5MyI+MTIxMzwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Qmlzc2V0dCwgQi4gTS48L2F1dGhvcj48

YXV0aG9yPkxlZGl0c2Noa2UsIEkuIEEuPC9hdXRob3I+PGF1dGhvcj5OZWVtYW4sIFQuPC9hdXRo

b3I+PGF1dGhvcj5Cb290cywgUi48L2F1dGhvcj48YXV0aG9yPlBhcmF0eiwgSi48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wgb2YgTWVkaWNpbmUs

IFVuaXZlcnNpdHkgb2YgUXVlZW5zbGFuZCwgQnJpc2JhbmUsIFF1ZWVuc2xhbmQsIEF1c3RyYWxp

YSBEaXNjaXBsaW5lIG9mIFBoeXNpb3RoZXJhcHksIFVuaXZlcnNpdHkgb2YgQ2FuYmVycmEsIEF1

c3RyYWxpYSBQaHlzaW90aGVyYXB5IERlcGFydG1lbnQsIENhbmJlcnJhIEhvc3BpdGFsLCBDYW5i

ZXJyYSwgQXVzdHJhbGlhbiBDYXBpdGFsIFRlcnJpdG9yeSwgQXVzdHJhbGlhLiYjeEQ7SW50ZW5z

aXZlIENhcmUgVW5pdCwgQ2FuYmVycmEgSG9zcGl0YWwsIENhbmJlcnJhLCBBdXN0cmFsaWFuIENh

cGl0YWwgVGVycml0b3J5LCBBdXN0cmFsaWEgSW50ZW5zaXZlIENhcmUgVW5pdCwgTWF0ZXIgSG9z

cGl0YWwsIEJyaXNiYW5lLCBRdWVlbnNsYW5kLCBBdXN0cmFsaWEgU2Nob29sIG9mIE1lZGljaW5l

LCBBdXN0cmFsaWFuIE5hdGlvbmFsIFVuaXZlcnNpdHksIENhbmJlcnJhLCBBdXN0cmFsaWFuIENh

cGl0YWwgVGVycml0b3J5LCBBdXN0cmFsaWEuJiN4RDtTdGF0aXN0aWNhbCBDb25zdWx0aW5nIFVu

aXQsIEF1c3RyYWxpYW4gTmF0aW9uYWwgVW5pdmVyc2l0eSwgQ2FuYmVycmEsIEF1c3RyYWxpYW4g

Q2FwaXRhbCBUZXJyaXRvcnksIEF1c3RyYWxpYS4mI3hEO1NjaG9vbCBvZiBNZWRpY2luZSwgVW5p

dmVyc2l0eSBvZiBRdWVlbnNsYW5kLCBCcmlzYmFuZSwgUXVlZW5zbGFuZCwgQXVzdHJhbGlhIElu

dGVuc2l2ZSBDYXJlIFVuaXQsIFJveWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0

YWwsIEhlcnN0b24sIFF1ZWVuc2xhbmQsIEF1c3RyYWxpYS4mI3hEO1NjaG9vbCBvZiBNZWRpY2lu

ZSwgVW5pdmVyc2l0eSBvZiBRdWVlbnNsYW5kLCBCcmlzYmFuZSwgUXVlZW5zbGFuZCwgQXVzdHJh

bGlhIEludGVuc2l2ZSBDYXJlIFVuaXQsIFJveWFsIEJyaXNiYW5lIGFuZCBXb21lbiZhcG9zO3Mg

SG9zcGl0YWwsIEhlcnN0b24sIFF1ZWVuc2xhbmQsIEF1c3RyYWxpYSBTY2hvb2wgb2YgQWxsbGll

ZCBIZWFsdGggU2NpZW5jZXMsIEdyaWZmaXRoIFVuaXZlcnNpdHksIEF1c3RyYWxpYS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNwaXJhdG9yeSBtdXNjbGUgdHJhaW5pbmcgdG8gZW5o

YW5jZSByZWNvdmVyeSBmcm9tIG1lY2hhbmljYWwgdmVudGlsYXRpb246IGEgcmFuZG9taXNlZCB0

cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaG9yYXg8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UaG9yYXg8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz44MTItOTwvcGFnZXM+PHZvbHVtZT43MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVt

YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5FeGVyY2lzZTwva2V5d29yZD48a2V5d29yZD5SZXNwaXJh

dG9yeSBNZWFzdXJlbWVudDwva2V5d29yZD48a2V5d29yZD5SZXNwaXJhdG9yeSBNdXNjbGVzPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDY4LTMyOTYgKEVsZWN0cm9u

aWMpJiN4RDswMDQwLTYzNzYgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI3MjU3MDAz

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmku

bmxtLm5paC5nb3YvcHVibWVkLzI3MjU3MDAzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxj

dXN0b20yPlBNQzUwMTMwODg8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEx

MzYvdGhvcmF4am5sLTIwMTYtMjA4Mjc5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA 12, and is relevant to both ICU patients (both ventilator-dependent and recently weaned) and patients with acute exacerbation of COPD towards the end of their inpatient stay. The ‘chronic’ IMT protocol is based on evidence in stable community-dwelling patients with chronic COPD and is more suitable in a pulmonary rehabilitation context. The chronic approach can also be applied to patients with stable congestive heart failure.Acute IMT Program:IndicationsVentilated ICU patients (> 7 days) that are alert and are able to actively participate with training but have failed to wean from mechanical ventilation by usual strategies (e.g. decreasing pressure support or t-piece trials)ICU patients recently weaned from mechanical ventilation > 7 days who are breathing spontaneouslyPatients admitted to the respiratory ward with an acute exacerbation of COPD, where a goal is long-term management of dyspnoea. Note: Patients are only suitable when the acute exacerbation is resolving and they are no longer distressed at rest. Ideally, prescription of IMT should occur in the 1-3 days prior to discharge, with the patient to continue independently following discharge.Patients are not suitable for IMT if the patient:cannot actively participate or communicate (gestures, pointing or mouthing words)is younger than 16 years of ageis pregnantunstable in any way (e.g. cardiovascular, neurological)requires excessive ventilatory support (e.g. positive end expiratory pressure (PEEP) > 10 cm H20 or fraction of inspired oxygen (FiO2) > 0.6 or are critically PEEP-dependenthas severe dyspnoea at rest orthe medical or physiotherapy staff deem the risks of brief disconnection from ventilation to be unacceptable for any reason.EquipmentAlcohol based hand rub Threshold Inspiratory Muscle Trainer device (Phillips Respironics): allows incrementally adjusted training pressures from 9cmH2O up to 41cmH2O pressure (refer to Figure 1)Figure 1. Threshold IMT deviceFlexible connector (ICU equipment store) for ICU patients with an ETT or tracheostomy.ProcedureIMT is only performed by physiotherapists who have completed the IMT Competency Package (see Attachment 5). IMT is initiated by the Health Professional (HP) level 3 Physiotherapist and may be performed by HP level 1-2 physiotherapists and physiotherapy students under supervision.Perform hand hygeine.Training should be conducted with the patient in high sitting position, preferably in a chair (Figure 3).For a spontaneously breathing patient, attach the mouth piece to the IMT device and apply the nose peg if the patient tends to breathe through their nose (optional). For a ventilator-dependent patient, attach the flexible tubing to the Threshold IMT. This will allow the Threshold IMT to attach directly to the tracheostomy/ETT (no mouthpiece required) (Figure 2). Figure 2: Attaching IMT device to ETTAdjusting intensity: If Negative Inspiratory Force (NIF) or Maximum Inspiratory Pressure (MIP) testing is available, intensity should be set at 50% of maximum effort to begin with. To adjust the pressure indicator to the setting prescribed, align the red edge of the pressure indicator by turning the control knob at the bottom of the Threshold IMT. The higher the number, the greater the resistance and effort required. If no NIF/MIP testing is available, the physiotherapist should aim for the highest tolerable intensity for a 6 breath sequence (achieved through trial and error).The intensity of resistance is adjusted incrementally between sets by the physiotherapist to ensure patient can just complete the 6th breath in each set.The patient inhales through the device to generate an inspiratory pressure greater than the indicated threshold pressure setting to compress the spring and open the poppet valve.The inspiratory pressure should be maintained for at least 1 second, with respiratory rate < 30 bpm. Audible air flow indicates a successful breath.The patient exhales through the training device via a low resistance one-way valve.Training sessions consist of 5 sets of 6 training breaths for a total of 30 training breaths per day. IMT should be conducted once per day, ideally in the morning, 5 days per week. Including rests between sets, this should take less than 10 minutes per day.If ventilator-dependent, patients are returned to mechanical ventilation for rest between training as needed. If spontaneously breathing, allow rests between sets as required (typically < 1 minute)The patient’s clinical parameters and response during training should be monitored if ventilator-dependent (i.e. Blood Pressure (BP), Heart Rate (HR), Respiratory Rate (RR), and SpO2 (peripheral capillary oxygen saturation)). Otherwise, monitor SpO2 and RR if oxygen-dependent (noting that supplemental oxygen is not required during IMT breaths) ADDIN EN.CITE <EndNote><Cite><Author>Bissett</Author><Year>2012</Year><RecNum>157</RecNum><DisplayText><style face="superscript">20</style></DisplayText><record><rec-number>157</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1285722268">157</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bissett, B., Leditschke, I.A., Green, M.</author></authors></contributors><titles><title>Specific inspiratory muscle training is safe in selected patients who are ventilator-dependent: A case series.</title><secondary-title>Intensive and Critical Care Nursing</secondary-title></titles><periodical><full-title>Intensive and Critical Care Nursing</full-title></periodical><pages>98-104</pages><volume>28</volume><dates><year>2012</year></dates><urls></urls><electronic-resource-num>10.1016/j.iccn.2012.01.003</electronic-resource-num></record></Cite></EndNote>20 Guidelines for ConcernPulse Oximetry Saturation decreases >5% from baseline Subjective signs of distress or severe sharp pain on inspirationCardiac arrhythmiasSigns and symptoms of secretion retention in ventilated patients – provide suction if indicated.Outcome/Progression MeasuresContinue training with the acute plan until patients have reached goal inspiratory muscle strength (eg MIP of 80 – 100 in previously well patient). This may include independent IMT at home following discharge from hospital.In patients with COPD, consider switching to chronic IMT approach after 6-8 weeks for maintenance.Patient EducationPatients/family/nursing staff should be carefully instructed on rationale for IMT, precautions and guidelines for treatment.DocumentationAll documentation should follow the Clinical Record Documentation Procedure. However with respect to IMT, the following should be specifically mentioned:Informed consent, see Consent and Treatment Policy on the policy register.Training Parameters used (resistance, sets, breaths)Response to treatment (any adverse outcomes).Cleaning Of EquipmentEquipment used for inspiratory muscle training is single-patient use only and disposable, therefore no cleaning or sterilising is required.Threshold IMT DeviceThe Threshold IMT device is for single patient use only. It should be stored in the patient’s bedside trolley with the patient’s sticker on it and can be used following discharge should the patient wish to.Chronic IMT Program ADDIN EN.CITE <EndNote><Cite><Author>Hill</Author><Year>2010</Year><RecNum>283</RecNum><DisplayText><style face="superscript">21</style></DisplayText><record><rec-number>283</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1288523905">283</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hill, K.</author><author>Cecins, N. M.</author><author>Eastwood, P. R.</author><author>Jenkins, S. C.</author></authors></contributors><auth-address>Curtin Health Innovation Research Institute, Curtin University, Perth, Australia. K.Hill@curtin.edu.au</auth-address><titles><title>Inspiratory muscle training for patients with chronic obstructive pulmonary disease: a practical guide for clinicians</title><secondary-title>Arch Phys Med Rehabil</secondary-title></titles><periodical><full-title>Arch Phys Med Rehabil</full-title></periodical><pages>1466-70</pages><volume>91</volume><number>9</number><edition>2010/08/31</edition><keywords><keyword>*Breathing Exercises/adverse effects</keyword><keyword>Humans</keyword><keyword>Patient Selection</keyword><keyword>Pulmonary Disease, Chronic Obstructive/*rehabilitation</keyword><keyword>Respiratory Function Tests</keyword></keywords><dates><year>2010</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1532-821X (Electronic)&#xD;0003-9993 (Linking)</isbn><accession-num>20801269</accession-num><urls><related-urls><url>(10)00320-5 [pii]&#xD;10.1016/j.apmr.2010.06.010</electronic-resource-num><language>eng</language></record></Cite></EndNote>21:IndicationsPatients with stable COPD who have inspiratory muscle weaknessparticularly those unable to participate in a weight-bearing exercise program like Pulmonary Rehabilitationparticularly those who have made minimal improvements following completion of a Pulmonary Rehabilitation programPatients with stable CHF.Patients are not suitable for IMT if:They have an undrained pneumothorax or are at risk of spontaneous pneumothorax (e.g. history of same)They are at risk of rib fractures (e.g. history of same)They have large bullae on chest x-rayThey have had lung surgery within the last 12 months.EquipmentThreshold IMT device (Phillips Respironics): allows incrementally adjusted training pressures from 9cmH2O up to 41cmH2O pressure. ProcedureTraining should be conducted with the patient in high sitting position, preferably in a chair with upper limbs supported (Figure 3).Figure 3. Position for IMTAdjusting intensity: intensity (target load) should be titrated to 30% of MIP to begin with. To adjust the pressure indicator to the setting prescribed, align the red edge of the pressure indicator by turning the control knob at the bottom of the Threshold IMT. Attach the mouth piece to the IMT device and apply the nose peg. The patient inhales through the device to generate an inspiratory pressure greater than the indicated threshold pressure setting to compress the spring and open the poppet valve. Audible air flow indicates a successful breath.Training should follow the pattern of 7 lots of 2 minute cycles, where target training equals 30% of MIP, and the warm-up load is 15% of MIP. Intensity should be increased as tolerated to maintain an RPE of 13-14 / 20 (or 4/10). IMT should be performed 3 days a week for a minimum of 8 weeks, and then continued indefinitely at 2 days a week for maintenance.Guidelines for ConcernPatient reports in sudden sharp pain on inspiration (refer for medical review, due to risk of pneumothorax)Outcome/Progression MeasuresRecommend monitoring SpO2 and RR during initial training session Review progress with MIP after 8 weeks of training – if no changes, cease IMT. If patient has improved, continue with maintenance program for life (2 sessions/week).Cleaning Of EquipmentEquipment used for IMT is single-patient use only and disposable, therefore no cleaning or sterilising is required.Back to Table of Contents Section 3 – HyperinflationBackgroundHyperinflation is the delivery of a slow, deep inspiration greater than baseline tidal volume up to a peak inspiratory pressure (PIP) of 40cm H2O, followed by an inspiratory hold of up to three seconds, and a quick, unobstructed expiration to patients with an artificial airway22. The slow deep inspiration to 35-40cm H20 re-expands areas of atelectasis23, the inspiratory hold recruits lung segments via collateral channels, allows for gas exchange and mobilises secretions, while the quick release increases expiratory flow rates, allows for annular two phase gas liquid flow, and mimics a huff and/or cough, mobilising pulmonary secretions from distal to proximal lung segments24. Hyperinflation has been shown to be an effective technique for mobilising sputum25-27 reversing atelectasis28, 29 improving oxygenation and pulmonary compliancePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OdG91bWVub3BvdWxvczwvQXV0aG9yPjxZZWFyPjE5OTg8

L1llYXI+PFJlY051bT4xMjk5PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBl

cnNjcmlwdCI+MzAsMzU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4x

Mjk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pk

dnBuMjlld3NlcnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjE1MDM2Mzg2OTQiPjEy

OTk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk50b3VtZW5vcG91bG9z

LCBHLjwvYXV0aG9yPjxhdXRob3I+R2lsZCwgQS48L2F1dGhvcj48YXV0aG9yPkNvb3BlciwgRC4g

Si48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UcmF1bWEg

SW50ZW5zaXZlIENhcmUgVW5pdCwgQWxmcmVkIEhvc3BpdGFsLCBNZWxib3VybmUsIFZpY3Rvcmlh

LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRoZSBlZmZlY3Qgb2YgbWFudWFsIGx1bmcg

aHlwZXJpbmZsYXRpb24gYW5kIHBvc3R1cmFsIGRyYWluYWdlIG9uIHB1bG1vbmFyeSBjb21wbGlj

YXRpb25zIGluIG1lY2hhbmljYWxseSB2ZW50aWxhdGVkIHRyYXVtYSBwYXRpZW50czwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5BbmFlc3RoIEludGVuc2l2ZSBDYXJlPC9zZWNvbmRhcnktdGl0bGU+

PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW5hZXN0aCBJbnRlbnNpdmUgQ2FyZTwv

ZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjQ5Mi02PC9wYWdlcz48dm9sdW1lPjI2PC92

b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3Jk

PjxrZXl3b3JkPkNyb3NzIEluZmVjdGlvbi9lcGlkZW1pb2xvZ3kvKnByZXZlbnRpb24gJmFtcDsg

Y29udHJvbDwva2V5d29yZD48a2V5d29yZD4qRHJhaW5hZ2UsIFBvc3R1cmFsPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+PGtleXdv

cmQ+UG5ldW1vbmlhL2VwaWRlbWlvbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3

b3JkPjxrZXl3b3JkPipSZXNwaXJhdGlvbiwgQXJ0aWZpY2lhbDwva2V5d29yZD48a2V5d29yZD5S

ZXNwaXJhdG9yeSBUaGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPldvdW5kcyBhbmQgSW5qdXJpZXMv

Y29tcGxpY2F0aW9uczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk4PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+T2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDMx

MC0wNTdYIChQcmludCkmI3hEOzAzMTAtMDU3WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+OTgwNzYwMjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85ODA3NjAyPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhvZGdzb248L0F1dGhvcj48WWVh

cj4yMDAwPC9ZZWFyPjxSZWNOdW0+MTI5MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTI5

MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InM5eHd6ZHZw

bjI5ZXdzZXJ0YXA1d3ZkYjk5ZnJlZDVwMjAwdiIgdGltZXN0YW1wPSIxNTAzNjM4MzM3Ij4xMjkz

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ib2Rnc29uLCBDLjwvYXV0

aG9yPjxhdXRob3I+RGVuZWh5LCBMLjwvYXV0aG9yPjxhdXRob3I+TnRvdW1lbm9wb3Vsb3MsIEcu

PC9hdXRob3I+PGF1dGhvcj5TYW50YW1hcmlhLCBKLjwvYXV0aG9yPjxhdXRob3I+Q2Fycm9sbCwg

Uy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbnRlbnNp

dmUgQ2FyZSBVbml0LCBTdCBWaW5jZW50JmFwb3M7cyBIb3NwaXRhbCwgTWVsYm91cm5lLCBWaWN0

b3JpYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BbiBpbnZlc3RpZ2F0aW9uIG9mIHRo

ZSBlYXJseSBlZmZlY3RzIG9mIG1hbnVhbCBsdW5nIGh5cGVyaW5mbGF0aW9uIGluIGNyaXRpY2Fs

bHkgaWxsIHBhdGllbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFuYWVzdGggSW50ZW5zaXZl

IENhcmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5B

bmFlc3RoIEludGVuc2l2ZSBDYXJlPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MjU1

LTYxPC9wYWdlcz48dm9sdW1lPjI4PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdvcmRz

PjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+

QW5hbHlzaXMgb2YgVmFyaWFuY2U8L2tleXdvcmQ+PGtleXdvcmQ+Qmxvb2QgUHJlc3N1cmUvcGh5

c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5DYXJib24gRGlveGlkZS9ibG9vZDwva2V5d29yZD48

a2V5d29yZD5Dcml0aWNhbCBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPipDcml0aWNhbCBJbGxuZXNz

PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IZWFydCBSYXRlL3Bo

eXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcv

KnBoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5MdW5nIENvbXBsaWFuY2UvKnBoeXNp

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdl

ZDwva2V5d29yZD48a2V5d29yZD5PeHlnZW4vYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+UG9zdHVy

ZTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3Jk

PlB1bG1vbmFyeSBBdGVsZWN0YXNpcy9waHlzaW9wYXRob2xvZ3kvdGhlcmFweTwva2V5d29yZD48

a2V5d29yZD5QdWxtb25hcnkgR2FzIEV4Y2hhbmdlL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+UmVzcGlyYXRpb24sIEFydGlmaWNpYWwvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+U2Fm

ZXR5PC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bTwva2V5d29yZD48a2V5d29yZD5TdWN0aW9uPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5KdW48L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMzEwLTA1N1ggKFByaW50KSYj

eEQ7MDMxMC0wNTdYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMDg1MzIwNTwvYWNj

ZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5u

aWguZ292L3B1Ym1lZC8xMDg1MzIwNTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OdG91bWVub3BvdWxvczwvQXV0aG9yPjxZZWFyPjE5OTg8

L1llYXI+PFJlY051bT4xMjk5PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBl

cnNjcmlwdCI+MzAsMzU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4x

Mjk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczl4d3pk

dnBuMjlld3NlcnRhcDV3dmRiOTlmcmVkNXAyMDB2IiB0aW1lc3RhbXA9IjE1MDM2Mzg2OTQiPjEy

OTk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk50b3VtZW5vcG91bG9z

LCBHLjwvYXV0aG9yPjxhdXRob3I+R2lsZCwgQS48L2F1dGhvcj48YXV0aG9yPkNvb3BlciwgRC4g

Si48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UcmF1bWEg

SW50ZW5zaXZlIENhcmUgVW5pdCwgQWxmcmVkIEhvc3BpdGFsLCBNZWxib3VybmUsIFZpY3Rvcmlh

LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRoZSBlZmZlY3Qgb2YgbWFudWFsIGx1bmcg

aHlwZXJpbmZsYXRpb24gYW5kIHBvc3R1cmFsIGRyYWluYWdlIG9uIHB1bG1vbmFyeSBjb21wbGlj

YXRpb25zIGluIG1lY2hhbmljYWxseSB2ZW50aWxhdGVkIHRyYXVtYSBwYXRpZW50czwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5BbmFlc3RoIEludGVuc2l2ZSBDYXJlPC9zZWNvbmRhcnktdGl0bGU+

PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW5hZXN0aCBJbnRlbnNpdmUgQ2FyZTwv

ZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjQ5Mi02PC9wYWdlcz48dm9sdW1lPjI2PC92

b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3Jk

PjxrZXl3b3JkPkNyb3NzIEluZmVjdGlvbi9lcGlkZW1pb2xvZ3kvKnByZXZlbnRpb24gJmFtcDsg

Y29udHJvbDwva2V5d29yZD48a2V5d29yZD4qRHJhaW5hZ2UsIFBvc3R1cmFsPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+PGtleXdv

cmQ+UG5ldW1vbmlhL2VwaWRlbWlvbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3

b3JkPjxrZXl3b3JkPipSZXNwaXJhdGlvbiwgQXJ0aWZpY2lhbDwva2V5d29yZD48a2V5d29yZD5S

ZXNwaXJhdG9yeSBUaGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPldvdW5kcyBhbmQgSW5qdXJpZXMv

Y29tcGxpY2F0aW9uczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk4PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+T2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDMx

MC0wNTdYIChQcmludCkmI3hEOzAzMTAtMDU3WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+OTgwNzYwMjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85ODA3NjAyPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhvZGdzb248L0F1dGhvcj48WWVh

cj4yMDAwPC9ZZWFyPjxSZWNOdW0+MTI5MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTI5

MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InM5eHd6ZHZw

bjI5ZXdzZXJ0YXA1d3ZkYjk5ZnJlZDVwMjAwdiIgdGltZXN0YW1wPSIxNTAzNjM4MzM3Ij4xMjkz

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ib2Rnc29uLCBDLjwvYXV0

aG9yPjxhdXRob3I+RGVuZWh5LCBMLjwvYXV0aG9yPjxhdXRob3I+TnRvdW1lbm9wb3Vsb3MsIEcu

PC9hdXRob3I+PGF1dGhvcj5TYW50YW1hcmlhLCBKLjwvYXV0aG9yPjxhdXRob3I+Q2Fycm9sbCwg

Uy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbnRlbnNp

dmUgQ2FyZSBVbml0LCBTdCBWaW5jZW50JmFwb3M7cyBIb3NwaXRhbCwgTWVsYm91cm5lLCBWaWN0

b3JpYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BbiBpbnZlc3RpZ2F0aW9uIG9mIHRo

ZSBlYXJseSBlZmZlY3RzIG9mIG1hbnVhbCBsdW5nIGh5cGVyaW5mbGF0aW9uIGluIGNyaXRpY2Fs

bHkgaWxsIHBhdGllbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFuYWVzdGggSW50ZW5zaXZl

IENhcmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5B

bmFlc3RoIEludGVuc2l2ZSBDYXJlPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MjU1

LTYxPC9wYWdlcz48dm9sdW1lPjI4PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdvcmRz

PjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+

QW5hbHlzaXMgb2YgVmFyaWFuY2U8L2tleXdvcmQ+PGtleXdvcmQ+Qmxvb2QgUHJlc3N1cmUvcGh5

c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5DYXJib24gRGlveGlkZS9ibG9vZDwva2V5d29yZD48

a2V5d29yZD5Dcml0aWNhbCBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPipDcml0aWNhbCBJbGxuZXNz

PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IZWFydCBSYXRlL3Bo

eXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcv

KnBoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5MdW5nIENvbXBsaWFuY2UvKnBoeXNp

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdl

ZDwva2V5d29yZD48a2V5d29yZD5PeHlnZW4vYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+UG9zdHVy

ZTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3Jk

PlB1bG1vbmFyeSBBdGVsZWN0YXNpcy9waHlzaW9wYXRob2xvZ3kvdGhlcmFweTwva2V5d29yZD48

a2V5d29yZD5QdWxtb25hcnkgR2FzIEV4Y2hhbmdlL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+UmVzcGlyYXRpb24sIEFydGlmaWNpYWwvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+U2Fm

ZXR5PC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bTwva2V5d29yZD48a2V5d29yZD5TdWN0aW9uPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5KdW48L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMzEwLTA1N1ggKFByaW50KSYj

eEQ7MDMxMC0wNTdYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMDg1MzIwNTwvYWNj

ZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5u

aWguZ292L3B1Ym1lZC8xMDg1MzIwNTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA 25,30. Traditionally, hyperinflation has been delivered to mechanically ventilated patients by disconnecting them from the ventilator and connecting them to a manual resuscitation circuit and is known as manual hyperinflation (MHI). At CHHS, the technique is delivered via the Laerdal Silicone Resuscitator bag (Figure 4). Disadvantages of this technique include loss of PEEP, de-recruitment of lung segments, and poor tolerance or dyssynchrony with the technique by agitated patients. When completed manually, substantial clinical experience is required to deliver the technique consistently and to prevent barotrauma or volutrauma31. Ventilator Hyperinflation (VHI) is the delivery of hyperinflation breaths via adjustments of ventilator settings and when compared to MHI, VHI has been shown to be as effective in mobilising secretions, improving lung compliance, oxygenation and restoring lung volumes32-35. It requires no disconnection from mechanical ventilation, so there is no loss of PEEP and it is synchronous with patient breaths. Volumes are delivered consistently and PIP and volume are controlled by the ventilator, thus reducing the risk of barotrauma or volutrauma in appropriately selected patients.In clinical practice, VHI is utilised in patients currently undergoing mechanical ventilation while MHI is mainly utilised in patients no longer requiring mechanical ventilation. Figure 4. Laerdal Silicone Resuscitator bagIndications for Hyperinflation36Evidence of retained secretions Evidence of collapse or loss of volumePoor lung complianceDecreased oxygenation caused by one of the above.Outcome MeasuresArterial blood gasesOxygen saturationsChest Radiograph (CXR)Volume/consistency of sputum suctionedTidal Volumes (Vt)Vital CapacityPeak Inspiratory Pressure (PIP)Ventilator Wave FormsStatic Compliance (Cstat=VT/Pplat-PEEP)AuscultationPalpation (chest wall movement/fremitus).Alert: In the presence of precautions to hyperinflation, treatment should proceed with caution after direct consultation with a senior physiotherapist, senior registrar or consultant.All paediatric cases where hyperinflation is indicated it must be discussed with a senior physiotherapist and the treating consultant. Consideration for seeking advice from paediatric specialty centres in the clinical reasoning process for complex cases is recommended.Precautions for Hyperinflation37Unstable cardiovascular system such as unstable arrhythmias, mean arterial pressure (MAP) <65 mmHg, the presence of an IABP; increasing inotropic or vasopressor support (as high intra-thoracic pressures may compromise venous return).Partial pressure of oxygen (PaO2)/FiO2 Ratio <200PIP >35 cmH20Airway Pressure Release Ventilation (APRV)Intra Cranial Pressure (ICP)>15 mmHgFlorid Acute Pulmonary Oedema (APO)Restrictive or obstructive lung diseaseSignificant pulmonary hypertension or evidence of right ventricular dysfunctionContraindications for Hyperinflation ADDIN EN.CITE <EndNote><Cite><Author>Dennis</Author><Year>2012</Year><RecNum>1328</RecNum><DisplayText><style face="superscript">43</style></DisplayText><record><rec-number>1328</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503640110">1328</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dennis, D.</author><author>Jacob, W.</author><author>Budgeon, C.</author></authors></contributors><auth-address>Sir Charles Gairdner Hospital, Perth, Western Australia. Diane.Dennis@health..au</auth-address><titles><title>Ventilator versus manual hyperinflation in clearing sputum in ventilated intensive care unit patients</title><secondary-title>Anaesth Intensive Care</secondary-title></titles><periodical><full-title>Anaesth Intensive Care</full-title></periodical><pages>142-9</pages><volume>40</volume><number>1</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Australia</keyword><keyword>Blood Pressure</keyword><keyword>Critical Care/*methods</keyword><keyword>Cross-Over Studies</keyword><keyword>Female</keyword><keyword>Heart Rate</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Physical Therapy Modalities</keyword><keyword>Respiration, Artificial/*methods</keyword><keyword>Respiratory Rate</keyword><keyword>Sputum/*metabolism</keyword><keyword>Tidal Volume</keyword><keyword>Time Factors</keyword><keyword>*Ventilators, Mechanical</keyword></keywords><dates><year>2012</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0310-057X (Print)&#xD;0310-057X (Linking)</isbn><accession-num>22313075</accession-num><urls><related-urls><url> Undrained pneumothorax or the presence of an ICC with continuous leakBroncho-pulmonary FistulaThoracic surgery with lung resection Patients ventilated on lung protective strategy for ARDS, severe pneumonia, pulmonary contusionsAcute bronchospasmPatients ventilated for an exacerbation of COPD with elevated intrinsic PEEP or other conditions where hyperinflation would be detrimentalPerforming MHIEquipmentAppropriate size Laerdel Silicone Resuscitator Bag (adult/paediatric)Heat Moist Exchange (HME) Filter In addition, ventilated patients require:PEEP Valve Test lung Procedure for MHIPhysiotherapists may only perform MHI once they have completed the Hyperinflation Competency package with the appropriate HP level 3 or above (Attachment 6).Identify indications for MHI and any precautions or contraindications. If precautions exist, discuss with appropriate senior physiotherapy staff and treating Consultant/Senior Registrar prior to initiating MHI.Ensure appropriate number of staff are available to carry out the treatment. Physiotherapists with less clinical experience or who have not performed the technique recently should consider a second staff member (nurse or physiotherapist) to be available to suction and place the ventilator on standby in the more unstable patient. For patients on vasoactive infusions or who have ICP monitoring, MHI should be carried out with the bedside nurse present as titration of infusions may be required during treatment. A second physiotherapist is required if manual techniques are indicated as an adjunct to MHI. Explain the treatment to the patient. Appropriately position the patient to maximise ventilation and perfusion (V/Q) matching and to drain secretions.To set up the MHI circuit (Figure 5), attach a HME filter to the Laerdel bag. For ventilated patients, ensure a PEEP valve set at the patient’s baseline PEEP setting is incorporated into the circuit. Figure 5. Circuit set up for the ventilated patientAttach the oxygen tubing to the oxygen outlet and turn the oxygen flow to 15 litres/minute. Ensure the reservoir bag is not split and is filling with gas. A manometer is not required to be used as the Laerdel circuit has a safety valve that prevents PIP from exceeding 35 cm H2O26.For the ventilated patient, silence the ventilator, disconnect the ventilator from junction of the Bennet’s connector and connect the patient to the Laerdel circuit. For the self-ventilating tracheostomised patient, disconnect oxygen and attach the Laerdel circuit to the tracheostomy via the flexible connector only (Figure 6).Figure 6. Circuit connection for the ventilated patientCommence hand ventilating the patient at the same rate and volume as baseline. Once satisfied that the patient is ventilating, place the ventilator in standby mode as per Physiotherapy Ventilator Assessment Tool (Attachment 7) and attach the ventilator to the test mence MHI with a two handed technique, delivering a larger than baseline tidal volume, an inspiratory hold and a quick release ADDIN EN.CITE <EndNote><Cite><Author>McCarren</Author><Year>1996</Year><RecNum>1329</RecNum><DisplayText><style face="superscript">44</style></DisplayText><record><rec-number>1329</rec-number><foreign-keys><key app="EN" db-id="s9xwzdvpn29ewsertap5wvdb99fred5p200v" timestamp="1503640354">1329</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McCarren, B.</author><author>Chow, C. M.</author></authors></contributors><auth-address>School of Physiotherapy, The University of Sydney, Lidcombe, NSW, 2141, Australia.</auth-address><titles><title>Manual hyperinflation: a description of the technique</title><secondary-title>Aust J Physiother</secondary-title></titles><periodical><full-title>Aust J Physiother</full-title></periodical><pages>203-208</pages><volume>42</volume><number>3</number><dates><year>1996</year></dates><isbn>0004-9514 (Print)&#xD;0004-9514 (Linking)</isbn><accession-num>11676651</accession-num><urls><related-urls><url>. The literature recommends six sets of six MHI breaths to treat atelectasis and compliancePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJuZXk8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxS

ZWNOdW0+MTI5NDwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjMyLDM5PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTI5NDwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InM5eHd6ZHZwbjI5ZXdz

ZXJ0YXA1d3ZkYjk5ZnJlZDVwMjAwdiIgdGltZXN0YW1wPSIxNTAzNjM4MzY1Ij4xMjk0PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CZXJuZXksIFMuPC9hdXRob3I+PGF1

dGhvcj5EZW5laHksIEwuPC9hdXRob3I+PGF1dGhvcj5QcmV0dG8sIEouPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBQaHlzaW90aGVyYXB5

LCBBdXN0aW4gSG9zcGl0YWwsIEhlaWRlbGJlcmcsIFZJQywgMzA4NCwgQXVzdHJhbGlhLiBzdWUu

YmVybmV5QGF1c3Rpbi5vcmcuYXU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5IZWFkLWRv

d24gdGlsdCBhbmQgbWFudWFsIGh5cGVyaW5mbGF0aW9uIGVuaGFuY2Ugc3B1dHVtIGNsZWFyYW5j

ZSBpbiBwYXRpZW50cyB3aG8gYXJlIGludHViYXRlZCBhbmQgdmVudGlsYXRlZDwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5BdXN0IEogUGh5c2lvdGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkF1c3QgSiBQaHlzaW90aGVyPC9mdWxsLXRpdGxlPjwv

cGVyaW9kaWNhbD48cGFnZXM+OS0xNDwvcGFnZXM+PHZvbHVtZT41MDwvdm9sdW1lPjxudW1iZXI+

MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2Vk

PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNy

b3NzLU92ZXIgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5EcmFpbmFnZSwgUG9zdHVyYWwvKm1l

dGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZWFkLURv

d24gVGlsdDwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkludHVi

YXRpb24sIEludHJhdHJhY2hlYWw8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5

d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QZWFrIEV4cGlyYXRvcnkgRmxvdyBS

YXRlPC9rZXl3b3JkPjxrZXl3b3JkPlBvc3R1cmU8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3Rp

dmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SZXNwaXJhdG9yeSBNZWNoYW5pY3M8L2tleXdv

cmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgVGhlcmFweS8qbWV0aG9kczwva2V5d29yZD48a2V5d29y

ZD5TcHV0dW0vKnNlY3JldGlvbjwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjwvZGF0ZXM+PGlzYm4+

MDAwNC05NTE0IChQcmludCkmI3hEOzAwMDQtOTUxNCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MTQ5ODcxODc8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTQ5ODcxODc8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2F2aWFuPC9BdXRob3I+

PFllYXI+MjAwNTwvWWVhcj48UmVjTnVtPjEzMDM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVy

PjEzMDM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzOXh3

emR2cG4yOWV3c2VydGFwNXd2ZGI5OWZyZWQ1cDIwMHYiIHRpbWVzdGFtcD0iMTUwMzYzOTM4NyI+

MTMwMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2F2aWFuLCBDLjwv

YXV0aG9yPjxhdXRob3I+Q2hhbiwgUC48L2F1dGhvcj48YXV0aG9yPlBhcmF0eiwgSi48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DYXJkaW9wdWxtb25hcnkg

UmVzZWFyY2ggVW5pdCwgNHRoIEZsb29yLCBQaGlsaXAgQmxvY2ssIEFsZnJlZCBIb3NwaXRhbCwg

TWVsYm91cm5lLCBWaWN0b3JpYSwgQXVzdHJhbGlhLiBDYW1pbGFfU2F2aWFuQGhvdG1haWwuY29t

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGVmZmVjdCBvZiBwb3NpdGl2ZSBlbmQt

ZXhwaXJhdG9yeSBwcmVzc3VyZSBsZXZlbCBvbiBwZWFrIGV4cGlyYXRvcnkgZmxvdyBkdXJpbmcg

bWFudWFsIGh5cGVyaW5mbGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFuZXN0aCBBbmFs

Zzwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFuZXN0

aCBBbmFsZzwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjExMTItNjwvcGFnZXM+PHZv

bHVtZT4xMDA8L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1

bHQ8L2tleXdvcmQ+PGtleXdvcmQ+RG91YmxlLUJsaW5kIE1ldGhvZDwva2V5d29yZD48a2V5d29y

ZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcg

Q29tcGxpYW5jZS9waHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+TW9kZWxzLCBBbmF0b21pYzwva2V5d29yZD48a2V5d29yZD5QZWFrIEV4cGlyYXRvcnkg

RmxvdyBSYXRlLypwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBvc2l0aXZlLVByZXNzdXJl

IFJlc3BpcmF0aW9uL2luc3RydW1lbnRhdGlvbi8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5S

ZXNwaXJhdG9yeSBEaXN0cmVzcyBTeW5kcm9tZSwgQWR1bHQvcGh5c2lvcGF0aG9sb2d5PC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5B

cHI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTI5OTkgKFByaW50KSYjeEQ7

MDAwMy0yOTk5IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTc4MTUzMDwvYWNjZXNz

aW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu

Z292L3B1Ym1lZC8xNTc4MTUzMDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+MTAuMTIxMy8wMS5BTkUuMDAwMDE0NzUwNS45ODU2NS5BQzwvZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJuZXk8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxS

ZWNOdW0+MTI5NDwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi

PjMyLDM5PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTI5NDwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InM5eHd6ZHZwbjI5ZXdz

ZXJ0YXA1d3ZkYjk5ZnJlZDVwMjAwdiIgdGltZXN0YW1wPSIxNTAzNjM4MzY1Ij4xMjk0PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CZXJuZXksIFMuPC9hdXRob3I+PGF1

dGhvcj5EZW5laHksIEwuPC9hdXRob3I+PGF1dGhvcj5QcmV0dG8sIEouPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBQaHlzaW90aGVyYXB5

LCBBdXN0aW4gSG9zcGl0YWwsIEhlaWRlbGJlcmcsIFZJQywgMzA4NCwgQXVzdHJhbGlhLiBzdWUu

YmVybmV5QGF1c3Rpbi5vcmcuYXU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5IZWFkLWRv

d24gdGlsdCBhbmQgbWFudWFsIGh5cGVyaW5mbGF0aW9uIGVuaGFuY2Ugc3B1dHVtIGNsZWFyYW5j

ZSBpbiBwYXRpZW50cyB3aG8gYXJlIGludHViYXRlZCBhbmQgdmVudGlsYXRlZDwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5BdXN0IEogUGh5c2lvdGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkF1c3QgSiBQaHlzaW90aGVyPC9mdWxsLXRpdGxlPjwv

cGVyaW9kaWNhbD48cGFnZXM+OS0xNDwvcGFnZXM+PHZvbHVtZT41MDwvdm9sdW1lPjxudW1iZXI+

MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2Vk

PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNy

b3NzLU92ZXIgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5EcmFpbmFnZSwgUG9zdHVyYWwvKm1l

dGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZWFkLURv

d24gVGlsdDwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkludHVi

YXRpb24sIEludHJhdHJhY2hlYWw8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5

d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QZWFrIEV4cGlyYXRvcnkgRmxvdyBS

YXRlPC9rZXl3b3JkPjxrZXl3b3JkPlBvc3R1cmU8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3Rp

dmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SZXNwaXJhdG9yeSBNZWNoYW5pY3M8L2tleXdv

cmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgVGhlcmFweS8qbWV0aG9kczwva2V5d29yZD48a2V5d29y

ZD5TcHV0dW0vKnNlY3JldGlvbjwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjwvZGF0ZXM+PGlzYm4+

MDAwNC05NTE0IChQcmludCkmI3hEOzAwMDQtOTUxNCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MTQ5ODcxODc8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTQ5ODcxODc8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2F2aWFuPC9BdXRob3I+

PFllYXI+MjAwNTwvWWVhcj48UmVjTnVtPjEzMDM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVy

PjEzMDM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzOXh3

emR2cG4yOWV3c2VydGFwNXd2ZGI5OWZyZWQ1cDIwMHYiIHRpbWVzdGFtcD0iMTUwMzYzOTM4NyI+

MTMwMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2F2aWFuLCBDLjwv

YXV0aG9yPjxhdXRob3I+Q2hhbiwgUC48L2F1dGhvcj48YXV0aG9yPlBhcmF0eiwgSi48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DYXJkaW9wdWxtb25hcnkg

UmVzZWFyY2ggVW5pdCwgNHRoIEZsb29yLCBQaGlsaXAgQmxvY2ssIEFsZnJlZCBIb3NwaXRhbCwg

TWVsYm91cm5lLCBWaWN0b3JpYSwgQXVzdHJhbGlhLiBDYW1pbGFfU2F2aWFuQGhvdG1haWwuY29t

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGVmZmVjdCBvZiBwb3NpdGl2ZSBlbmQt

ZXhwaXJhdG9yeSBwcmVzc3VyZSBsZXZlbCBvbiBwZWFrIGV4cGlyYXRvcnkgZmxvdyBkdXJpbmcg

bWFudWFsIGh5cGVyaW5mbGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFuZXN0aCBBbmFs

Zzwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFuZXN0

aCBBbmFsZzwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjExMTItNjwvcGFnZXM+PHZv

bHVtZT4xMDA8L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1

bHQ8L2tleXdvcmQ+PGtleXdvcmQ+RG91YmxlLUJsaW5kIE1ldGhvZDwva2V5d29yZD48a2V5d29y

ZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcg

Q29tcGxpYW5jZS9waHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+TW9kZWxzLCBBbmF0b21pYzwva2V5d29yZD48a2V5d29yZD5QZWFrIEV4cGlyYXRvcnkg

RmxvdyBSYXRlLypwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBvc2l0aXZlLVByZXNzdXJl

IFJlc3BpcmF0aW9uL2luc3RydW1lbnRhdGlvbi8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5S

ZXNwaXJhdG9yeSBEaXN0cmVzcyBTeW5kcm9tZSwgQWR1bHQvcGh5c2lvcGF0aG9sb2d5PC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5B

cHI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTI5OTkgKFByaW50KSYjeEQ7

MDAwMy0yOTk5IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTc4MTUzMDwvYWNjZXNz

aW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu

Z292L3B1Ym1lZC8xNTc4MTUzMDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+MTAuMTIxMy8wMS5BTkUuMDAwMDE0NzUwNS45ODU2NS5BQzwvZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA 32,39. For sputum clearance, continue MHI if patient is stable until outcome measures indicate that sputum has been cleared.For all patients, monitor HR and SPO2 throughout. If available, monitor MAP, electrocardiogram (ECG), ICP and Cerebral Perfusion Pressure (CPP). ICP should remain below target, and CPP should remain >60 mmHg (CPP=MAP-ICP). Modify or cease treatment as appropriate.Suction the patient as indicated.Once treatment is complete, for ventilated patients restart the ventilator before reconnecting the patient and ensure the patient is ventilating at baseline or appropriate respiratory rate and with adequate tidal volumes and End Tidal Carbon Dioxide (ETCO2) prior to putting the Laerdal bag away. For ward patients, return patient to previous oxygen circuit e.g. humidified or Swedish nose.Reassess outcome measures and reposition patient appropriately.Document patient position, level of PEEP (if applicable), duration of MHI, appropriate outcome measures and any adverse eventsPerforming VHI Physiotherapists may only perform VHI once they have completed the Hyperinflation Competency package and ventilator training package with the appropriate HP Level 3 or above Physiotherapist (Attachments 6 and 7). The bedside nurse must be present during VHI.Identify indications for VHI, most appropriate mode of ventilation to deliver. hyperinflation for the specific patient, and any precautions or contraindications. If precautions exist, discuss with appropriate senior physiotherapy staff and treating Consultant/Senior Registrar prior to initiating VHI.Alert: VHI can only be performed in SIMV-Volume Control on the GE Carescape Ventilator. Explain the treatment and gain consent from the patient/carer and inform the bed side nurse. Appropriately position the patient to maximise ventilation and perfusion (V/Q) matching and to drain secretions.Adjust ventilator alarm limits (refer to Attachment 8).Adjust ventilator settings to achieve hyperinflation breaths (refer to Attachment 8). Titrate settings during treatment as required to maintain PIP at 35-40 cm of H20.Once target PIP is reached, manual techniques (i.e. percussion or vibration) may be incorporated if indicated.Monitor HR, MAP, ECG and ETCO2 throughout. If measured, ICP should remain below target, and cerebral perfusion pressure should remain >60 mmHg (CPP=MAP-ICP). Modify or cease treatment as appropriate.For patients who may require breaks during treatment due to intolerance of the technique or to prevent haemodynamic instability, return them to their baseline settings in that mode of ventilation. When resuming hyperinflation breaths, the determined values required to reach PIP of 40cmH2O can be resumed without the gradual increase in settings.Suction the patient as required.Dosage - The literature recommends six sets of six VHI breaths to treat atelectasis and improve compliance32,33,38. For sputum clearance, continue VHI if patient is stable until outcome measures indicate that sputum has been cleared.Once treatment is completed, return ventilator settings to baseline return patient to previous mode of ventilation and return alarm settings to previous limits. Inform the bedside nurse that alarm limits and ventilator settings are at baseline. Ensure patient is ventilating at adequate rate, Vt and ETCO2 prior to reassessing outcome measures and repositioning the patient as required.Document the patient position, mode of ventilation, RR, PIP reached, Vt reached, duration of treatment and any adverse events.Back to Table of ContentsSection 4 – Induced Sputum CollectionThis section outlines the processes for receipt and management of referral and safe collection of an induced sputum sample through inhalation of hypertonic saline.BackgroundThe inhalation of hypertonic saline solutions via an ultrasonic nebuliser has been shown to induce production of small amounts of secretions from the airways in patients who are not able to expectorate sputum. The mechanism of this process is not fully understood though hypothesised that increased osmolarity of bronchial lining fluid increase vascular permeability in the bronchial mucosa and production of mucus by submucosal glands. Induced sputum is used in the diagnosis of pulmonary Tuberculosis (TB) and Pneumocystis Jirovecii Pneumonia (PJP), formally known as Pneumocystis Carinii Pneumonia (PCP) 39. Current guidelines suggest that for PJP a single sample needs to be induced for testing. For TB, three samples on consecutive days are required to increase sensitivity of the test40, 41. These can be either spontaneous sputum samples or induced samples. There is evidence to suggest that airway clearance techniques such as percussion and vibrations have no benefit in inducing sputum42.Precautions/Contraindications43 Inadequate respiratory reserve or acute respiratory distressInability to follow instructionsFiO2 >50%Haemoptysis of unknown originUnstable cardiovascular statusThoracic, abdominal or cerebral aneurysmsFEV1 <1.0 LitresPneumothoraxPulmonary emboli.Referrals - generalReferral for induced sputum collection will be accepted from a Medical Specialist/VMO from Intensive Care, Respiratory, Oncology, Haematology or Infectious Diseases only.For inpatients, referral must be documented in the patient’s clinical file, including the purpose for collection. The medical team is to contact the ward physiotherapist via pager to alert them to the referral as soon as possible.Requests are accepted during standard business hours (excluding special circumstances). Refer to “Weekends/out of business hours” for details. For outpatients, a written referral (including patient contact details) will be sent to: Physiotherapy Department Building 15, Canberra Hospital, Yamba Drive Garran 2605, or faxed on 62443692, with a pathology form attached.Alert: If induced sputum is requested for conditions other than TB and PCP, this must be discussed by the treating consultant with a senior physiotherapist.Weekends/out of business hoursMicrobiology is unable to routinely process an induced sputum sample on weekends or public holidays. If the testing is urgent then the requesting medical team will contact the Microbiologist on-call to ensure availability of laboratory staff prior to referral to the physiotherapist for collection.PCP collection requests made over a weekend/Public Holiday will be collected as soon as possible and sent to Microbiology, even if they are unable to be processed over the weekend, to allow for higher diagnostic yield.Requests made for collection after 3.30pm will be delayed until the following business day due to the time taken to collect and process.The physiotherapy evening service (5pm-9pm) will not routinely perform induced sputum collection.SafetyTo minimise the risk of transmission of airborne disease:All induced sputum collections are to be completed in a single room with adequate room ventilation. Refer to attachment 9 for list of appropriate rooms.PPE is compulsory during collection including gown, gloves, goggles and fine particulate respiratory mask.All staff performing a TB collection are required to have a baseline Mantoux test or Tuberculin Skin Test (TST) with CHHS Department of Respiratory and Sleep Medicine (DRSM), which requires 12 monthly updates/reviews.The physiotherapist conducting the procedure will remain with the patient.Should the patient be required to leave the ward for collection then a nurse escort may be required at the discretion of the Clinical Nurse Consultant (CNC) (depending on the patient’s acuity).Alert: It is recommended that bronchodilators and anti-emetics are charted prior to commencing sputum induction due to risk of bronchospasm and nausea. It is recommended that known asthmatic patients have a bronchodilator prior to collection to minimise the risk of bronchospasm and airway compromise44.PreparationOn referral for an induced sputum, the following preparation is required:Referring medical team:inform ward CNC and patient flow unit of the need for the patient to be in a negative pressure roomcontact microbiology if outside normal business hours to ensure sample able to be processedChart 6% Hypertonic salineChart bronchodilators and anti-emetics if required.The ward CNC/Team Leader:Ensure that a negative pressure room is available on the treating wardIf a negative pressure room cannot be organised on the treating ward, liaise with Patient Flow Unit to source a negative pressure room on another ward. Refer to attachment 9 for a list of appropriate rooms. Physiotherapist:Arrange a room for outpatient collections.Ensure all equipment required is available.EquipmentSuchatzki Ultrasonic nebuliser and one-way mouthpiece, including disposable items:bacterial filtermedicine cupdust filter6% Hypertonic saline solution (in premix 10ml sachet)44,45,46 PPE including gown, gloves, goggles and high particulate respiratory maskSputum specimen jarTissuesSterile waterPulse oximeterProcedureGain informed consent from the patient, as per Consent and Treatment Policy on the policy register.Access negative pressure room for collection. If using the room solely for collection purposes, drape a sheet over where the patient will be sitting.Administer bronchodilators and supplemental oxygen if indicated.Perform hand hygiene and don PPE.Explain the procedure to the patient what to expect.Ensure patient is comfortable and in a sustainable position.Perform baseline observations (SpO2, RR and auscultation).Prepare nebuliser with 10ml hypertonic saline solution in disposable cup, and sterile water in the main water chamber up to the recommended marked ‘fill’ line. Refer to Attachment 10 for machine setup. Instruct patient to breathe slowly and deeply.After 5 minutes of inhalation, if no spontaneous cough has occurred, instruct patient to cough. Repeat at 5 minute intervals until a sample is produced44-46. Continue to monitor patient throughout procedure.After 30 mins if no sample obtained, cease the procedure and inform medical team.Repeat observations and ensure patient is stable.Document result of collection attempt in the patient’s clinical record, and data collection of the attempt in the Physiotherapy record book for Induced Sputum.If successful, label sample as “Induced Sputum” and send with pathology form to Microbiology. Refer to Attachment 11 if procedure is unsuccessful. If used, place any draped sheets into the linen skip.Dispose of consumables in yellow bin outside the room.The room requires cleaning before use by another patient. Leave the room vacant for one hour and then contact the cleaning service to clean the floors, walls and furniture with detergent and water. Clean the machine as below.Alert: Morning sample collection is preferable as they are more sensitive for detecting TB47 CleaningWipe nebuliser with soap impregnated wipe Tubing and water vessel are sent to DRSM for thermal disinfection and air dried.Mouthpiece and one way valve are sent to Gastroenterology & Hepatology Unit for sterilizationFilters and the medicine cup are disposable after each test.Back to Table of Contents Implementation This guideline will be implemented via the following:Available for reference to all CHHS Physiotherapy staff and Physiotherapy students via the policy register on SharePoint.Distribution at department communication and team meetings.Inclusion in staff munication with key stakeholders and workgroups.Monitoring through peer review, documentation audits and clinical practice audits.Back to Table of ContentsRelated Policies, Procedures, Guidelines and LegislationPoliciesWork Health and Safety PolicyConsent and Treatment PolicyClinical Records Management PolicyProceduresCHHS Healthcare Associated Infections Clinical ProcedureCHHS Patient Identification and Procedure Matching PolicyAdult Nebulisation Therapy ProcedureInhaled Bronchodilator Delivery for Adults OnlyClinical Record Documentation ProcedureGuidelines Physiotherapy – Adult Patient with a Spinal Cord InjuryTracheostomy Management Adult PatientsClinical Supervision for Allied Health CliniciansCredentialing and Defining the Scope of Clinical Practice for Allied Health ProfessionalsOxygen Therapy and or Non-Invasive Ventilation PaediatricsPhysiotherapy – Adult Patient with a Spinal Cord InjuryLegislationHealth Records (Privacy and Access) Act 1997Human Rights Act 2004Work Health and Safety Act 2011Back to Table of ContentsReferences ADDIN EN.REFLIST 1.Irwin RS, Boulet LP, Cloutier MM, et al. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians. Chest. 1998;114(2 Suppl Managing):133S-181S.2.Homnick DN. Mechanical insufflation-exsufflation for airway mucus clearance. Respir Care. 2007;52(10):1296-1305; discussion 1306-1297.3.Whitney JA, Harden B, Keilty S. Assisted cough: a new technique. Physiotherapy. 2002;88(4):201-207.4.Liszner K, Feinberg M. Cough assist strategy for pulmonary toileting in ventilator dependent spinal cord injured patients. Rehabilitation Nursing. 2006;31(5):218-221.5.Chatwin M, Simonds AK. The addition of mechanical insufflation/exsufflation shortens airway-clearance sessions in neuromuscular patients with chest infection. Respir Care. 2009;54(11):1473-1479.6.Fauroux B, Guillemot N, Aubertin G, et al. Physiologic benefits of mechanical insufflation-exsufflation in children with neuromuscular diseases. Chest. 2008;133(1):161-168.7.Emerson 3200 User Manual.8.Guerin C, Bourdin G, Leray V, et al. Performance of the coughassist insufflation-exsufflation device in the presence of an endotracheal tube or tracheostomy tube: a bench study. Respir Care. 2011;56(8):1108-1114.9.Shoemaker MJ, Donker S, Lapoe A. Inspiratory muscle training in patients with chronic obstructive pulmonary disease: the state of the evidence. Cardiopulm Phys Ther J. 2009;20(3):5-15.10.Dall'Ago P, Chiappa GR, Guths H, Stein R, Ribeiro JP. Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. J Am Coll Cardiol. 2006;47(4):757-763.11.Cader SA, Vale RG, Castro JC, et al. Inspiratory muscle training improves maximal inspiratory pressure and may assist weaning in older intubated patients: a randomised trial. J Physiother. 2010;56(3):171-177.12.Bissett BM, Leditschke IA, Neeman T, Boots R, Paratz J. Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial. Thorax. 2016;71(9):812-819.13.Bissett BG, M. Leditschke, IA. Inspiratory muscle training is safe in selected ventilated patients: a case series. in preparation. 2010.14.Hill K, Jenkins SC, Philippe DL, et al. High-intensity inspiratory muscle training in COPD. Eur Respir J. 2006;27(6):1119-1128.15.Johnson MA, Sharpe GR, Brown PI. Inspiratory muscle training improves cycling time-trial performance and anaerobic work capacity but not critical power. Eur J Appl Physiol. 2007;101(6):761-770.16.Cahalin LP, Semigran MJ, Dec GW. Inspiratory muscle training in patients with chronic heart failure awaiting cardiac transplantation: results of a pilot clinical trial. Phys Ther. 1997;77(8):830-838.17.Sprague SS, Hopkins PD. Use of inspiratory strength training to wean six patients who were ventilator-dependent. Phys Ther. 2003;83(2):171-181.18.Martin AD, Davenport PD, Franceschi AC, Harman E. Use of inspiratory muscle strength training to facilitate ventilator weaning: a series of 10 consecutive patients. Chest. 2002;122(1):192-196.19.Bissett B, Leditschke IA. Inspiratory muscle training to enhance weaning from mechanical ventilation. Anaesth Intensive Care. 2007;35(5):776-779.20.Bissett B, Leditschke, I.A., Green, M. Specific inspiratory muscle training is safe in selected patients who are ventilator-dependent: A case series. Intensive and Critical Care Nursing. 2012;28:98-104.21.Hill K, Cecins NM, Eastwood PR, Jenkins SC. Inspiratory muscle training for patients with chronic obstructive pulmonary disease: a practical guide for clinicians. Arch Phys Med Rehabil. 2010;91(9):1466-1470.22.McCarren B, Chow CM. Manual hyperinflation: a description of the technique. Aust J Physiother. 1996;42(3):203-208.23.Rothen HU, Sporre B, Engberg G, Wegenius G, Hedenstierna G. Re-expansion of atelectasis during general anaesthesia: a computed tomography study. Br J Anaesth. 1993;71(6):788-795.24.Maxwell L, Ellis E. Secretion clearance by manual hyperinflation. Possible mechanisms. Physiotherapy Theory and Practice. 1998;14:189-197.25.Hodgson C, Denehy L, Ntoumenopoulos G, Santamaria J, Carroll S. An investigation of the early effects of manual lung hyperinflation in critically ill patients. Anaesth Intensive Care. 2000;28(3):255-261.26.Hodgson C, Ntoumenopoulos G, Dawson H, Paratz J. The Mapleson C circuit clears more secretions than the Laerdal circuit during manual hyperinflation in mechanically-ventilated patients: a randomised cross-over trial. Aust J Physiother. 2007;53(1):33-38.27.Berney S, Denehy L, Pretto J. Head-down tilt and manual hyperinflation enhance sputum clearance in patients who are intubated and ventilated. Aust J Physiother. 2004;50(1):9-14.28.Stiller K, Geake T, Taylor J, Grant R, Hall B. Acute lobar atelectasis. A comparison of two chest physiotherapy regimens. Chest. 1990;98(6):1336-1340.29.Maa SH, Hung TJ, Hsu KH, et al. Manual hyperinflation improves alveolar recruitment in difficult-to-wean patients. Chest. 2005;128(4):2714-2721.30.Ntoumenopoulos G, Gild A, Cooper DJ. The effect of manual lung hyperinflation and postural drainage on pulmonary complications in mechanically ventilated trauma patients. Anaesth Intensive Care. 1998;26(5):492-496.31.Rusterholz B, Ellis E. The effect of lung compliance and experience on manual hyperinflation. Aust J Physiother. 1998;44(1):23-28.32.Berney S, Denehy L. A comparison of the effects of manual and ventilator hyperinflation on static lung compliance and sputum production in intubated and ventilated intensive care patients. Physiother Res Int. 2002;7(2):100-108.33.Savian C, Chan P, Paratz J. The effect of positive end-expiratory pressure level on peak expiratory flow during manual hyperinflation. Anesth Analg. 2005;100(4):1112-1116.34.Ahmed F, Shafeeq AM, Moiz JA, Geelani MA. Comparison of effects of manual versus ventilator hyperinflation on respiratory compliance and arterial blood gases in patients undergoing mitral valve replacement. Heart Lung. 2010;39(5):437-443.35.Dennis DM, Jacob WJ, Samuel FD. A survey of the use of ventilator hyperinflation in Australian tertiary intensive care units. Crit Care Resusc. 2010;12(4):262-268.36.Hanekom S, Berney S, Morrow B, et al. The validation of a clinical algorithm for the prevention and management of pulmonary dysfunction in intubated adults--a synthesis of evidence and expert opinion. J Eval Clin Pract. 2011;17(4):801-810.37.Dennis D, Jacob W, Budgeon C. Ventilator versus manual hyperinflation in clearing sputum in ventilated intensive care unit patients. Anaesth Intensive Care. 2012;40(1):142-149.38.Paratz J, Lipman J, McAuliffe M. The effect of manual hyperinflation, gas exchange, and respiratory mechanics in ventilated patients. . Journal of Intensive Care Medicine. 2002;17(6):317-324.39.Paggiaro PL, Chanez P, Holz O, et al. Sputum induction. Eur Respir J Suppl. 2002;37:3s-8s.40.Al Zahrani K, Al Jahdali H, Poirier L, Rene P, Menzies D. Yield of smear, culture and amplification tests from repeated sputum induction for the diagnosis of pulmonary tuberculosis. Int J Tuberc Lung Dis. 2001;5(9):855-860.41.McWilliams T, Wells AU, Harrison AC, Lindstrom S, Cameron RJ, Foskin E. Induced sputum and bronchoscopy in the diagnosis of pulmonary tuberculosis. Thorax. 2002;57(12):1010-1014.42.Elkins MR, Lane T, Goldberg H, et al. Effect of airway clearance techniques on the efficacy of the sputum induction procedure. Eur Respir J. 2005;26(5):904-908.43. JV, Boushey HA, Lazarus SC, et al. Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. Am J Respir Crit Care Med. 2001;163(6):1470-1475.45.Kelly MG, Brown V, Martin SL, Ennis M, Elborn JS. Comparison of sputum induction using high-output and low-output ultrasonic nebulizers in normal subjects and patients with COPD. Chest. 2002;122(3):955-959.46.Popov TA, Pizzichini MM, Pizzichini E, et al. Some technical factors influencing the induction of sputum for cell analysis. Eur Respir J. 1995;8(4):559-565.47.Schoch OD, Rieder P, Tueller C, et al. Diagnostic yield of sputum, induced sputum, and bronchoscopy after radiologic tuberculosis screening. Am J Respir Crit Care Med. 2007;175(1):80-86.Back to Table of ContentsDefinition of TermsPaO2/FiO2 Ratio-the ratio of partial pressure of oxygen (PaO2) to fraction of inspired oxygen (FiO2), also known as the PF ratio19.Peak Inspiratory Pressure (PIP)-point of maximal airway pressure on inspiration, measured in centimetres of water19Back to Table of ContentsSearch Terms CAM, Cough assist, Cough assist machine, Physiotherapy, Airway clearance, Inspiratory Muscle Training, Intensive Care, Critical Care, Mechanical ventilation, Respiratory management, Sputum clearance, Atelectasis, Manual Hyperinflation, Induced Sputum CollectionBack to Table of ContentsAttachmentsAttachment 1 – Assessing Peak cough flow Attachment 2 – Assembly of Cough Assist MachineAttachment 3 – Modifying Cough Assist Machine settingsAttachment 4 – Cough Assist Machine Competency Assessment for Physiotherapists Attachment 5 – Physiotherapy Competency Assessment- Inspiratory Muscle TrainingAttachment 6 – Physiotherapy Competency Assessment-HyperinflationAttachment 7 – Ventilator Assessment Tool for PhysiotherapistsAttachment 8 – Ventilator Hyperinflation Procedure Flowchart Attachment 9 – List of rooms for Induced Sputum collection at Canberra HospitalAttachment 10 – Induced Sputum mouthpiece components and assemblyAttachment 11 – Physiotherapy Induced Sputum flowchartDisclaimer: This document has been developed by ACT Health, Canberra Hospital and Health Services specifically for its own use. Use of this document and any reliance on the information contained therein by any third party is at his or her own risk and Health Directorate assumes no responsibility whatsoever.Policy Team ONLY to complete the following:Date AmendedSection AmendedDivisional ApprovalFinal Approval 24/01/2018Complete ReviewKerry Boyd, DAH, MedicineCHHS Policy CommitteeThis document supersedes the following: Document NumberDocument NameCHHS13/513Physiotherapy - Induced Sputum CollectionCHHS13/327Physiotherapy Use of Manual HyperinflationCHHS13/441Physiotherapy Inspiratory Muscle Training for Ventilated Patients (Adults)CHHS15/159Physiotherapy - Ventilator Hyperinflation in Adult Mechanical Ventilated PatientsCHHS16/240Physiotherapy use of Cough assist to enhance pulmonary secretion clearanceAttachment 1 – Assessing Peak cough flowPeak Cough Flow can be assessed using the Phillips Respironics Cough Assist E70Assessing Peak Cough Flow:Perform hand hygiene.Set up a pre-set to be in manual mode, inhale pressure 0cmH2O and exhale pressure 0cmH2O.For a patient with spinal cord injury, place them supine to maximise vital capacity.Select Therapy from the Standby screen.Apply the interface to the patient.Ask the patient to take a deep breath and cough.While the patient is taking the deep breath turn the manual control lever to inhale. When the patient commences coughing, quickly turn the manual control lever to exhale.Remove the interface and record the baseline peak cough flow.Perform hand hygiene.For further information on interpretation of peak cough values see the Appendix 3 in the Physiotherapy – Adult Patient with a Spinal Cord Injury clinical guideline on the policy register.Attachment 2 – Assembly of Cough Assist Machine861695362585Emerson CA-3200 Cough AssistPhillips Respironics Cough Assist E70Attachment 3 –Modifying Cough Assist Machine settings Phillips Respironics Cough Assist E7010Navigating the standby screenWhen the machine is turned on the standby screen will appear Detailed view will either be turned on or off. To turn detailed view on or off enter the Menu and select Options. Then scroll to Detailed View and toggle between on/off. Changing between full access and limited accessTo change patient settings full access needs to be enabled. Once the machine has been configured, the access should be returned to limited access in order to prevent the settings being changed by someone that is not trained to do so.To turn on full access:From the standby screen press the down button and hold the manual control lever to the right (inhale). The unlocked graphic in the top right hand corner of the screen indicates that the machine is in full access mode.To turn on limited access:From the standby screen select Menu > Options > Menu Access. Press the Modify key and toggle to Limited Access.Adjusting patient settingsEnsure ‘full access’ has been enabled. Press the left key (under the word ‘settings’ on the screen).The screen below will appear. Use the up/down and modify keys to change the settings for each pre-set.To return to the standby screen select Finish by using the left key.Emerson CA-3200 cough assist3Pressure adjustmentPerform hand hygiene.Turn on the power switch.Select inhale flow to full or reduced.Block the mask end of the breathing hose with your hand.Set the manual/ auto switch to manual.Push the manual control lever to the exhalation phase (to the left). Observe the pressure gauge on the device and adjust the maximum negative pressure by using the pressure knob to achieve the correct reading on the gauge.Shift the manual control lever to the inhalation phase (push to the right). Adjust the pressure reading by turning the inhale pressure knob to achieve the desired reading on the pressure gauge.Cycle the manual control lever from inhale to exhale and back a few times to ensure that the pressure and suction readings are correct. On release of the manual control lever check that the pressure returns to 0cmH2O. Attachment 4 – Cough Assist Machine Competency Assessment for Physiotherapists Outcome Statement: The Physiotherapist demonstrates appropriate knowledge and skill to clinically reason and safely use the CAM in the management of adult and paediatric patients.Assessment RequirementsTheory Completed:□ Read Physiotherapy Respiratory Management clinical guideline, Section 1 – Cough Assist to enhance pulmonary clearance□ Read Physiotherapy – Adult Spinal Cord Injury (excluding staff who work solely with paediatric clients)2 types of CAM are available, the Emerson CA-3200 and the Philips Respironics Cough Assist E70. Staff must be assessed as competent on the machine that they are planning to use to treat the patient.This assessment is made up of PARTS A-D. All staff must be assessed as competent in PART A: Indications and ContraindicationsStaff assessed as competent in PART C: CAM Application/Treatment but not PART B: CAM Set-up and Prescription may use the CAM as a treatment option once it has been set-up and prescribed by a staff member who has been assessed as competent in PART BStaff must be assessed as competent in PART D: Peak Cough Flow to measure peak cough flow through the CAM. Note that this can be measured using a face mask and a peak flow meter (refer to Physiotherapy – Adult Spinal Cord Injury Guideline on the policy register)If a staff member is found not yet competent against an assessment item further training is conducted until that staff member is assessed as competent. Staff members can request training and assessment to be conducted by another staff member.Overall Assessment: COMPETENT (C) / NOT YET COMPETENT (NYC)/ CONDITIONAL (please circle)Comments: Candidate:Date:SignaturePrint NameDesignationAssessor:Date:SignaturePrint NameDesignationPerformance CriteriaCNYCPART A – Indications & ContraindicationsDiscuss the clinical indication/s for the CAM and 3 therapy adjuncts to assist with secretion clearanceList 3 patient populations/diagnosis who may require the CAM List 2 contraindications/precautions and explain the clinical reasoning for eachDiscuss clinical reasoning for performing CAM in supine for patients with a spinal cord injuryPART B – CAM Set-up and PrescriptionDiscuss different interfaces available and rationale for selectionDiscuss factors to consider when initiating CAM for the first time and ranges of pressure required to achieve effective secretion clearanceEmerson CA-3200Philips E-70Set-up & PrescriptionCNYCCNYCEquipment assembled and per procedurePerforms appropriate pressure and timing adjustments to achieve effective prescriptionExplains rationale for in-sufflation and ex-sufflation (repetitions & sets, rests) PART C – CAM Application/TreatmentInformed consent / consent obtained from patient (if possible) or reason consent unable to be obtained noted in medical fileMachine settings checked with prescriptionDemonstrates ability to use manual and automatic modeTreatment performed as prescribed and/or treatment outcome achievedTherapy Adjuncts and MonitoringCNYCAppropriate adjunct techniques performed as clinically indicatedAppropriate monitoring during treatment and treatment modified as/if indicatedDocumentationProcedure documented in accordance to Physiotherapy Documentation standards. Including:Sets, repetitions, rests, mode, timing adjustment, pressures, physiological response to treatmentPART D – Peak Cough Flow (Phillips Respironics E-70)Discuss clinical reasoning for assessing peak cough flowMeasures peak cough flow as per procedureDiscuss clinical implications of the patients peak cough flowProcedure documented in accordance to Physiotherapy Documentation standards. Attachment 5 – Physiotherapy Competency Assessment Inspiratory Muscle Training Outcome Statement: The Physiotherapist demonstrates appropriate knowledge and skill to clinically reason and safely use IMT in adult mechanically ventilated patients.Assessors: Physiotherapy staff with specialised skills in intensive care and inspiratory muscle training as identified by the Physiotherapy Manager/Team Leader (Health Professional level 4). Assessment RequirementsStaff must be assessed as competent in all assessment criteria to achieve overall IMT competency. Performance CriteriaCNYCIndications & ContraindicationsNeed for IMT is identified (based on low NIF / MIP)Checked for any contraindications/precautions to IMTExplains procedure and rationale to patient Informed consent gained from patientProcedure Appropriately positions the patientApplies IMT device to tracheostomy / ETT via connectorFollows training guidelines (6 breaths, 5 sets)Monitors patient’s parameters and response during training against parameters set by ICU Consultant.Training progressed as per guidelines (just complete 6th breath each set)MonitoringMonitors appropriate parameters throughout treatmentModifies treatment as required or discusses how treatment may need to be modified in certain clinical situationsCeases treatment in presence of safety concerns or discusses safety criteria when treatment would need to ceaseDocumentationProcedure documented in MetaVision using the IMT form. Overall Assessment:COMPETENT (C) / NOT YET COMPETENT (NYC)/ CONDITIONAL (please circle)Comments: Candidate:Date:SignaturePrint NameDesignationAssessor:Date:SignaturePrint NameDesignationAttachment 6 –Hyperinflation Competency AssessmentOutcome Statement: The Physiotherapist demonstrates appropriate knowledge and skill to clinically reason and safely use hyperinflation.Assessors: physiotherapy staff with specialised skills in respiratory management as identified by the Physiotherapy Manager/Team Leader (Health Professional Level 4). Assessment RequirementsTheory Completed:Read Physiotherapy Respiratory Management guideline-Hyperinflation (Section 3)Hyperinflation Self Directed Learning Package or Department inserviceAttendedPhysiotherapy Ventilator Competency completed (for VHI)Staff may be assessed as competent in either MHI or VHI.Staff must be deemed competent in all assessment criteria to achieve overall competency. Staff are required to achieve competency performing VHI in each of the modes of mechanical ventilation. Achieving competency in performing VHI in one mode of ventilation does not mean the staff member is competent in performing VHI in another mode. Staff must not perform VHI in a mode of mechanical ventilation that they have not been assessed as competent in. Simulation may be used in training and assessment. In addition to achieving competency in hyperinflation, staff must also be assessed as ventilator competent for VHI, as well as in closed suction for both techniques before the treatment technique can be performed independently.If a staff member if found not yet competent against an assessment item further training is conducted until that staff member is assessed as competent. Staff members can request training and assessment to be conducted by another staff member.Overall Assessment: COMPETENT (C) / NOT YET COMPETENT (NYC)/ CONDITIONAL (please circle)CommentsCandidate Name DateSignature Designation Assessor Name DateSignature Designation Performance CriteriaCNYCIndications & ContraindicationsDiscuss the 2 main clinical indications for hyperinflationOutline the theoretical background of hyperinflation, including the target peak airway pressureDiscuss 5 contraindications/precautions and explain the clinical reasoning for eachIdentifies appropriate outcome measures to assess the effectiveness of treatmentAble to identify the differences between VHI and MHIAble to justify the choice of either VHI or MHI and indications/benefit of chosen treatment modalityProcedure-VHIInformed consent / consent obtained from patient (if possible) or reason consent unable to be obtained noted in medical fileAppropriately positions the patientSelects the most appropriate mode of ventilation to perform VHIGE CarescapeVentilatorMarquet Servo UCNYCCNYCIdentifies baseline alarm settingsAdjusts alarms Performs & titrates VHI Volume controlPressure controlProvides appropriate dosageMonitoringMonitors appropriate parameters throughout treatmentModifies treatment as required or discusses how treatment may need to be modified in certain clinical situationsCeases treatment in presence of safety concerns or discusses safety criteria when treatment would need to ceaseRe-assessment & Post Treatment ProcedureGE CarescapeVentilatorMarquet Servo UCNYCCNYCRe-assesses outcome measuresReturns patient to baseline ventilator settingsReturns alarm settings to baseline parametersDocumentationProcedure documented in accordance to Physiotherapy Documentation standards in MetaVision using the VHI form. Including:Mode of ventilation, Peak Inspiratory Pressure, respiratory rate, tidal volume, dosageProcedure -MHIInformed consent / consent obtained from patient (if possible) or reason consent unable to be obtained noted in medical fileAppropriately positions the patientPrepares equipment and work area (Laerdal bag, PEEP valve, suction, ventilator)Appropriately disconnects patient from the ventilator/oxygen therapy, safely connects patient to Laerdel bag and places ventilator in standby modeDemonstrates effective manual hyperinflation techniqueProvides appropriate dosageMonitoringMonitors appropriate parameters throughout treatmentModifies treatment as required or discusses how treatment may need to be modified in certain clinical situationsCeases treatment in presence of safety concerns or discusses safety criteria when treatment would need to ceaseRe-assessment & Post Treatment ProcedureRe-assesses outcome measuresTakes ventilator off standby, safely reconnects patient to ventilator/oxygen therapyDocumentationProcedure documented in accordance to Physiotherapy Documentation standards in patients clinical record Including:PEEP level, position of patient, dosageAdvanced Hyperinflation-PaediatricAble to describe to physiological differences between adults and childrenAble to modify treatment technique based on patients age, lung development and sizeAttachment 7 – Ventilator Assessment Tool for PhysiotherapistsOutcome Statement: The physiotherapist demonstrates appropriate knowledge and skill to independently and safely treat adult patients mechanically ventilated via the GE Carescape ventilator and the Marquet Servo U.Assessment RequirementsTraining Completed: This assessment consists of 2 parts:PART A – Mechanical Ventilation Knowledge and Skills PART B – Advanced Mechanical Ventilator SkillsStaff must be assessed as competent in all criteria of PART A prior to independently assessing and treating a mechanically ventilated patient. PART B may be completed for staff developing specialised skills in mechanical ventilation. Competency must be achieved prior to performing any skill or procedure independently.If a staff member is found ‘not yet competent’ against an assessment item further training is conducted until that staff member is assessed as competent. Staff members can request training and assessment by another staff member.This assessment can be completed over time and does not need to be completed in a single assessment session. Overall Assessment: COMPETENT (C) / NOT YET COMPETENT (NYC)/ CONDITIONAL (please circle)Comments: Candidate Name DateSignature Designation Assessor Name DateSignature Designation PART A – Mechanical Ventilation Knowledge and SkillsCNYCDescribes the different types and modes of ventilationPressure Support Ventilation (PSV)Synchronised Intermittent Mandatory Ventilation-Pressure Control (SIMV-PC)Synchronised Intermittent Mandatory Ventilation-Volume Control (SIMV-VC)Pressure Regulated Volume Control (PRVC)GE Carescape VentilatorMarquet Servo UCNYCCNYCIdentifies pre-set parameters where applicable: Mode, PEEP, Pressure Support, FiO2, tidal volume (Vt), respiratory rate (frequency)Identifies patients:Peak Airway Pressure (PAw), PEEP FiO2Vt respiratory rate (frequency) end tidal CO2 (ETCO2) Alarm Settings:Locates and identifies alarm limits (Vt, RR, PIP, ETCO2)Demonstrates how to adjust alarm limits (PIP, Vt)Demonstrates how to silence alarmsLocate the:Humidifier and demonstrate how to silence the alarmETCO2 monitor and where to attach the laerderal bagInspiratory and expiratory ventilator tubingIdentify which breaths are spontaneous and which breaths are mandatory on SIMV or PCVApnoea Ventilation:Discuss the role of apnoea ventilation including the mode of ventilationLocate the apnoea ventilation settingsOutline 2 treatments that could cause apnoea ventilation to be triggered and the theoretical rationale for eachIdentify a patient who is in apnoea ventilationReset apnoea ventilationDemonstrates how to change the mode of ventilation, FiO2, PEEP & PS and outline the process to follow if ventilator settings require changingDemonstrates how to pre-oxygenate patients prior to suction and how many second remainOutline the process to follow if the ventilator stopped workingDemonstrate how to safely remove excess water from ventilator tubingDemonstrates how to put the ventilator in ‘Stand-by Mode’ and safety factors to considerPART B – Advanced Mechanical Ventilation SkillsGE Carescape VentilatorMarquet Servo UCNYCCNYCAccurately calculates static compliance (Cstat=VT/Pplat-PEEP) and discusses how it can be used as an outcome measureSafely perform Negative Inspiratory Force (NIF) manoeuvre (through diagnostics) & Inspiratory HoldMeasures Vital Capacity (VC) and discusses clinical reasoning for measuring VCMeasures FRC and is able to apply to clinical decision makingSet-up and applies High Flow Nasal Prongs through the ventilator Set-up and applies Non-Invasive Ventilation through the ventilatorMobilisationCNYCOutline the Multidisciplinary Team process to follow prior to mobilising a ventilated patient away from the bedspaceSafely sets-up the ventilator to be used in battery mode for mobilisation Transfers onto portable oxygen with a spare oxygen cylinder availablePortable suction available and set up ready for useSafely leads a mobilisation episode with the ventilator in battery modeVentilator WaveformDiscuss when to assess waveformsIdentifies and discusses implications for physiotherapy of the following waveforms:Saw tooth expiratory patternsProlonged expirationGas trappingAttachment 8-Ventilator Hyperinflation Procedure FlowchartAttachment 9 – List of negative pressure rooms in CHHSLocationNumber of RoomsAntenatal1Coronary Care Unit2Intensive Care Unit4Neonatal Intensive Care Unit1Ward 5B1Ward 6A1Ward 7A2Ward 7B1Ward 8A procedure rooms*2Ward 8B1Ward 14B1Emergency Department 3Paediatric adolescent ward2Paediatric medical ward3Paediatric surgical ward1Gastroenterology and Hepatology Unit(GEHU)* 1 *If a negative pressure room is unavailable, these rooms are available via booking. Bookings for 8A procedure rooms are through the 8B CNC. Bookings for GEHU are arranged through GEHU CNC or team leader, phone 62443970. Note: these rooms may have limited availability due to other procedures.Attachment 10 – Induced Sputum mouthpiece components and assembly19051905Exploded view showing all components1905-5080Mouthpiece assembledAttachment 11 – Flowchart for requests for Induced Sputum collection ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download