DRUGS THAT CAN CAUSE HYPONATRAEMIA

DRUGS THAT CAN CAUSE HYPONATRAEMIA

Diuretics Thiazides

Loop

Potassium sparing

Combined

Bendroflumethiazide Furosemide

Amiloride

Co-Amilozide

Chlortalidon Cyclopenthiazide

Bumetanide Torazemide

Triamterene Spironolactone*

Co-Amilofruse Burinex

Indapamide

Eplerenone*

Metolazone Xipamide

Losartan**

Valsartan** Ibersartan**

*Aldosterone antagonist, **Angiotensin II receptor antagonist

Anti-depressants All anti-depressants can cause hyponatraemia.

Tricyclic Antidepressants and drugs related to tricyclic anti-depressants

Tricyclic Antidepressants

Sedative Amitriptyline

Clomipramine

Less sedative Imipramine Lofepramine

Related to tricyclic anti-depressants

Mianserin

Trazodone

Dosulepin

Nortriptyline

Doxepin

Trimipramine

Phenothiazines

Sedative effects Antimuscarinic

Extrapyramidal

Group 1

+++

++ ++ Promazine Chlorpromazine Levomepromazine

Group 2

++

+++ +

Pericyazine Pipotiazine

Selective serotonin re-uptake inhibitors (SSRI's) Citalopram Escitalopram Fluoxetine (Prozac) Fluvoxamine Paroxetine Sertraline

Mono aminine oxidase inhibitors (MAO inhibitors) Phenelzine Isocarboxiacid Tranylcypromine Moclobemide (reversible MAO inhibitor)

Proton pump inhibitors Omeprazol Lansoprazol Esomeprasol

Group 3

+

+ +++ Fluphenazine Perphenazine Prochlorerazine Trifluoperazine

Other Flupentixol

Venfalaxine (Efexor) Mirtazapine Duloxetine Reboxetine Tryptophan Gliclizide Glimepiride Carbamazepine (Tegretol) Valproic acid (Kepra)

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