AVISE Interpretation Guide - Advanced Testing For Lupus ...
AVISE? Interpretation Guide
ENA Markers
SLE Associated Markers
AVISE Interpretation Guide
SSAALLVVEEIISSPEMErooLCnuTitpDours AVISE APS
Marker (method)
EC4d (FACS) BC4d (FACS)
C4d (FACS)
XX X X
C3/C4 (IT)
Anti-C1q (ELISA)
Associated Disease
Prevalence 46-66%1
% 44% 60%
Anti-dsDNA IgG (ELISA and IIF)
Anti-dsDNA IgG
X
(CIA)
Anti-Nuclear Antibodies (ANA) (ELISA and IIF)
Anti-Ribosomal P
X
(ELISA)
Anti-Smith IgG X X (ELISA)
Marker (method)
Anti-CENP IgG
XX
(ELISA)
Anti-Jo-1 IgG
XX
(ELISA)
Anti-RNP70
X
(ELISA)
Anti-Scl-70 IgG X (ELISA)
A (CIA)
A (CIA)
A
Pol III
(ELISA)
Anti-SS-B/La IgG X X (ELISA)
Anti-U1RNP IgG (ELISA)
Anti-Histone (ELISA)
30-40%3 43% 97% 30%
Associated Disease
Prevalence 20-60%7 20-30%5
90%
S
S
S
M
S
S
S
M
S
28-70%6
40-60%8
95-99%11
Lupus 95%
1
Interpretation Interpretation
s
all of the
RA Markers
Marker (method)
Anti-Cyclic
Citrullinated
XX
Peptide IgG
(ELISA)
Associated Disease
Prevalence
70-90%12
(ELISA)
-2
Rheumatoid Factor X IgM & IgA (ELISA)
Marker (method) 2-Glycoprotein 1 IgG, IgM & IgA (CIA)
Cardiolipin IgG, IgM & IgA (CIA)
X*
AntiPhosphatidylserine /Prothrombin (PS/PT) IgM & IgG (ELISA)
Marker (method) Thyroglobulin IgG (ELISA)
Thyroid Peroxidase IgG (ELISA)
70-90%12
XX
Associated Disease
Prevalence 45%
97%
XX
o
38-49%1 XX
Associated Disease
Prevalence 60-85%1
71-97%1
AVISE HCQ
to
Interpretation
Interpretation
Interpretation t t
AVISE MTX
to
APS Markers
Thyroid Markers
Underexposed
or
( 10 U/mL EC4d > 75 Net MFI BC4d > 200 Net MFI
Anti-dsDNA > 301 U/ML
Positive
If Tier 1 is Negative move to Tier 2
Tier 2 criteria combines CB-CAPs with additional markers to yield an aggregate index value
Tier 2
Tier 2 generates an index value based on the following components ? ANA component ? CB-CAPs component ?
3
AVISE? CTD and AVISE Lupus result report
The result for the AVISE Lupus lotted along a gradient of increasing
likelihood for presence of SLE (See page 6 for likelihood ratios)
Analytes included in Tier 1 and Tier 2 along with respective assessments are reported in two distinct sections
4
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