Laboratory Approach to the Diagnosis of Amyloidosis
[Pages:1]Laboratory Approach to the Diagnosis of Amyloidosis
Possible Patient Presentations Nephrotic-range proteinuria with or without renal insuf ciency (nondiabetic) In ltrative cardiomyopathy with restrictive hemodynamics and no ischemic history Hepatomegaly with no lling defects visible by imaging Nondiabetic peripheral neuropathy Fatigue, weight loss, dyspnea, edema, or paresthesias Macroglossia Classic amyloid purpura Atypical myeloma
ALWAYS ORDER
PEISO / Protein Electrophoresis and Isotype, Serum MPSU / Monoclonal Protein Study, 24 Hour, Urine FLCS / Immunoglobulin Free Light Chains, Serum Subcutaneous Fat Aspirate (fat aspirate with Congo red stain)
Subcutaneous fat aspirate: Congo red amyloid deposits are present
Subcutaneous fat aspirate is negative but clinician still has high index of suspicion
Diagnostic for amyloidosis
Specific organ biopsy with Congo red to assess for amyloid
POSITIVE Diagnostic for amyloidosis
NEGATIVE
To identify the type of amyloid protein:
Acceptable specimen is paraffin-embedded tissue, order: AMPIP / Amyloid Protein Identification, Paraffin, LC-MS/MS
Special instructions applying ONLY to Mayo Clinic sites in Rochester, Jacksonville, and Scottsdale/Phoenix: If specimen is fat aspirate in RPMI media, order: Amyloid Protein Identification, Fat Aspirate, LC-MS/MS
Unlikely to be amyloidosis if involved organ biopsy is negative.
Prognostic/Monitoring Tests: Echocardiography-Doppler-Strain CRCL / Creatinine Clearance, Serum and 24-Hour Urine TRPS / Troponin T, 5th Generation, Serum PBNP / NT-Pro B-Type Natriuretic Peptide, Serum FLCS / Immunoglobulin Free Light Chains, Serum PCPRO / Plasma Cell DNA Content and Proliferation, Bone Marrow MFCF / Myeloma, FISH, Fixed Cells
Note: In cases of suspected familial amyloidosis, see Amyloidosis (Familial) Test Algorithm
? Mayo Foundation for Medical Education and Research (MFMER). All rights reserved.
03/2021
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