Outline Programme



4th International Mendelian randomization conference Outline Programme*indicates an invited talk.Wednesday 17th July, 2019Registration open from 8:30 in the Foyer9:30 Session 1, Lecture Theatre 19:30-9:40 Opening address, Professor Hugh Brady, Vice-Chancellor and President, University of Bristol9:40-10:10 Keynote lecture: Professor George Davey Smith, MRC Integrative Epidemiology Unit, UKMendelian randomization: where did it come from and where is it going?10:10-10:40 Benjamin Voight*, University of Pennsylvania, USAMendelian randomization studies in the Million Veteran’s Program10:40 - 11:30 Break11:30 Session 2, Lecture Theatre 1Chair: Benjamin Voight*, University of Pennsylvania, USA11:30-12:00 Cecilia Lindgren*, Nuffield Department of Medicine, University of Oxford, UKTitle: TBC12:00-12:15 David Evans, University of Queensland Diamantina Institute, Brisbane, Australia and MRC Integrative Epidemiology Unit, University of Bristol, UKUsing Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes12:15-12:30 Liang-Dar Hwang, University of Queensland, AustraliaUsing a novel two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight12:30 -13:00 Lunch12:30-14:00 Poster session 114:00 Sessions 3, 4 and 53. Detecting and adjusting for pleiotropy Lecture Theatre 14. Maternal environmentLecture Theatre 25. CancerLecture Theatre 3Chair: Neil Davies, MRC Integrative Epidemiology Unit, UKChair: Dave Evans, University of Queensland Diamantina Institute, Brisbane, AustraliaChair: Richard Martin, MRC Integrative Epidemiology Unit, UK14:00-14:30 Qingyuan Zhao*, University of Pennsylvania, USA The Statistics of Summary-Data Mendelian Randomization14:30-14:45 Apostolos Gkatzionis, MRC Biostatistics Unit, University of Cambridge, UKBayesian Variable Selection with a Pleiotropic Loss Function for Mendelian Randomization14:45-15:00 Wes Spiller, MRC Integrative Epidemiology Unit, UKTesting and correcting for violation of the constant pleiotropy assumption in MR-GxE analyses15:00-15:15 Chin Yang Shapland, MRC Integrative Epidemiology Unit, UKBayesian model averaging for two-sample summary data mendelian randomisation in the presence of pleiotropy15:15-15:30 Jessica Rees, University of EdinburghFactorial Mendelian randomization: using genetic variants to assess interactions14:00-14:30 Rachael Freathy*, Institute of Biomedical and Clinical Science, University of Exeter, UKInsights into the causal nature of associations between maternal exposures and offspring birth weight14:30-14:45 Qian Yang, MRC Integrative Epidemiology Unit, University of Bristol, UKProxy gene × environment Mendelian randomization study confirms causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health14:45-15:00 William Thompson, Institute of Biomedical and Clinical Science, University of Exeter, UKEffects of maternal adiposity on birth weight when coupled with favourable and unfavourable metabolic effects: A Mendelian Randomization study15:00-15:15 Robin Beaumont, Institute of Biomedical and Clinical Science, University of Exeter, UKCollider bias is unlikely to influence interpretation of results when estimating intrauterine effects using mother-child pairs15:15-15:30 Gunn-Helen Moen, Institute for Clinical medicine, University of Oslo, Norway and University of Queensland Diamantina Institute, AustraliaInvestigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight14:00-14:15 James Yarmolinsky, MRC Integrative Epidemiology Unit, University of Bristol, UKGenetic inhibition of HMG-CoA reductase and epithelial ovarian cancer risk: a Mendelian randomization analysis14:15-14:30 Daniela Mariosa, International Agency for Research on Cancer Are we underestimating the role of BMI on the cancer burden?14:30-14:45 Mark Gormley, MRC Integrative Epidemiology Unit, UKLifetime number of sexual partners and the risk of head and neck cancer: a Mendelian randomization analysis14:45-15:00 Nabila Kazmi, MRC Integrative Epidemiology Unit, UKAppraising causal relationships of dietary, nutritional and physical activity exposures with overall and aggressive prostate cancer: two-sample Mendelian randomization study15:00-15:15 Rebecca Richmond, MRC Integrative Epidemiology Unit, UKAssessing the causal effect of sleep characteristics on prostate cancer risk15:15-15:30 Kostas Tsilidis, Imperial College London, UKCirculating concentrations of micro-nutrients and risk of colorectal cancer: a Mendelian randomization study15:30 – 16:00 Break16:00 Sessions 6, 7 & 86. MethodologyLecture Theatre 17. Multivariable MR and mediation analysisLecture Theatre 28. InstrumentsLecture Theatre 3Chair: Dan Lawson, MRC Integrative Epidemiology Unit, UKChair: Eleanor Sanderson, MRC Integrative Epidemiology Unit, UKChair: Carolina Borges, MRC Integrative Epidemiology Unit, UK16:00-16:30 Frank Dudbridge*, Department of Health Sciences, University of Leicester, UKGenetic based adjustments for selection bias in studies of disease progression and survival16:30-16:45 Laurence Howe, MRC Integrative Epidemiology Unit, UKEvaluating evidence for assortative mating using genotype data16:45-17:00 Ciarrah Barry, MRC Integrative Epidemiology Unit, UKExploiting collider bias to apply two-sample MR methods in the one-sample setting 16:00-16:15 Alice Carter, MRC Integrative Epidemiology Unit, UKWhat explains the effect of education on cardiovascular disease? Applying Mendelian randomisation to identify the consequences of education inequality16:15-16:30 Amanda Hughes, MRC Integrative Epidemiology Unit, UKCommon health conditions in childhood and adolescence, educational attainment and absenteeism in the Avon Longitudinal Study of Parents and Children (ALSPAC)16:30-16:45 Guanghao Qi, Johns Hopkins Bloomberg School of Public Health, USAMultivariable MRMix accounting for known and unknown confounders leads to improved robustness and efficiency16:30-17:00 Emily Jamieson, MRC Integrative Epidemiology Unit, UK Smoking, DNA methylation and lung function: a Mendelian randomization analysis to investigate causal relationships16:00-16:15 Dipender Gill, Department of Biostatistics and Epidemiology, Imperial College London, UKStrategies for identifying instruments in Mendelian randomization16:15-16:30 Lai Jiang, Lady Davis Institute, McGill University, USAMultimodal Solutions for Valid Instrument Selection in Mendelian Randomization16:30-16:45 Hyunseung Kang, Department of Statistics, University of Wisconsin-Madison, USAWeak-Instrument Robust Methods for Two-Sample Summary MR16:45-17:00 Carlo Berzuini, Centre for Biostatistics, University of Manchester, UK Bayesian Mendelian Randomization identifies disease causing proteins via pedigree data, partially observed exposures and correlated instruments17:00-18:00 Poster session 2 Thursday 18th July, 20199:00 Session 9: Omics and colocalizationLecture Theatre 1Chair: Tom Gaunt, MRC Integrative Epidemiology Unit, UK9:00-9:30 Chris Wallace*, MRC Biostatistics Unit, Cambridge, UK Assessing colocalisation of causal variants for different traits: understanding and relaxing the assumptions of the coloc method9:30-9:45 Tom Richardson, MRC Integrative Epidemiology Unit, UKA transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome9:45-10:00 Karsten Sieber, GlaxoSmithKlineInstrumenting the Transcriptome at Scale: eQTL Colocalization Across the UK Biobank for Target Identification10:00-10:15 Christopher Foley, MRC Biostatistics Unit, Cambridge, UKA fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits10:15-10:30 Jie Zheng, MRC Integrative Epidemiology Unit, UKSystematic Mendelian randomization analysis mapping the influence of the plasma proteome and transcriptome on complex diseases10:30 -11:00 Break11:00 Sessions 10, 11, and 12 10. Genetics of common, complex diseaseLecture Theatre 111. MethodologyLecture Theatre 212. Cardiovascular diseaseLecture Theatre 3Chair: Laura Corbin, MRC Integrative Epidemiology Unit, UKChair: Qingyuan Zhao, University of Pennsylvania, USAChair: Tom Richardson, MRC Integrative Epidemiology Unit, UK11:00-11:30 Benjamin Neale*, Massachusetts General Hospital and Broad Institute, USA Looking to the Horizon: Genetics at Scale11:30-11:45 Benjamin Elsworth, MRC Integrative Epidemiology Unit, UK Deriving GWAS phenotype communities using distance data and graph algorithms11:45-12:00 Liza Darrous, University Center for Primary Care and Public Health, Lausanne, SwitzerlandSimultaneous Estimation of Heritability, Genetic Confounding, and Bi-directional Causal Effect from GWAS Summary Statistics12:00-12:15 Yi Liu, MRC Integrative Epidemiology Unit, UK Computing systematic polygenic risk scores associations using biobank-wide association scan12:15-12:30 Yue-miao Zhang, Peking University First Hospital, ChinaTrans-ethnic Mendelian randomization analysis reveals potential causal risk factors for chronic kidney disease12:30-12:45 Kaitlin Wade, MRC Integrative Epidemiology Unit, UK Genome-wide associations of the human gut microbiome variation and causal inference analysis11:00-11:15 Jack Bowden, MRC Integrative Epidemiology Unit, UKOn the validity of Mendelian randomization analyses with a binary exposure: The case against CACE11:15-11:30 Matthew Tudball, MRC Integrative Epidemiology Unit, UK An interval estimation approach to selection bias in Mendelian randomisation studies11:30-11:45 Fernando Hartwig, Federal University of Pelotas, Brazil Assessing the plausibility of the INSIDE assumption in two-sample Mendelian randomization11:45-12:00 Yoonsu Cho, MRC Integrative Epidemiology Unit, UKMR-TRYX: Exploiting horizontal pleiotropy to infer novel causal pathways12:10-12:15 Xia Shen, University of Edinburgh, UKInferring causation from heterogeneity in genetic correlations of complex traits12:15-12:30 Gibran Hemani, MRC Integrative Epidemiology Unit, UK Obtaining instruments for DNA methylation levels from 32,851 samples enables insights into the human genotype-phenotype map11:00-11:15 Frida Emanuelsson, Rigshospitalet, Copehagen University Hospital, DenmarkHigh glucose concentrations and risk of microvascular disease and peripheral arterial disease in the general population – an observational and Mendelian randomization study11:15-11:30 Inge Verkouter, Leiden University Medical Center, LeidenThe contribution of tissue-specific BMI-associated gene sets to cardiometabolic disease risk: a Mendelian Randomization study11:30-11:45 Mary Schooling, CUNY School for Public Health, New York, USA, University of Hong Kong, China Reproduction and longevity A Mendelian randomization study of gonadotropin-releasing hormone and ischemic heart disease11:45-12:00 Stephen Burgess MRC Biostatistics Unit, Cambridge, UKA robust and efficient method for Mendelian randomization with hundreds of genetic variants: unravelling mechanisms linking HDL-cholesterol and coronary heart disease12:00-12:15 Sean Bankier, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UKCausal inference for the reconstruction of cortisol responsive gene networks12:15-12:30 Kwok Man Ki, University of Hong Kong Cortisol and ischemic heart disease, type 2 diabetes and cardiovascular disease risk factors: a Mendelian randomization study12:30-12:45 Genevieve Leyden A transcriptome-wide Mendelian Randomization study of cardiovascular disease to prioritise genetic targets for therapeutic intervention 12:45 -13:30 Lunch12:45-14:00 Poster session 314:00 Sessions 13, 14, 1513. Metabolic and cardiovascular traitsLecture Theatre 114. Behavioural and cognitive outcomesLecture Theatre 215. Drug targetsLecture Theatre 3Chair: Chris Wallace, MRC Biostatistics Unit, Cambridge, UKChair: Jorien Treur, Department of Psychiatry, University of Amsterdam, The NetherlandsChair: Robert Scott, GSK, UK14:00-14:30 Hanieh Yaghootkar*, University of Exeter, UKUsing genetics to understand the consequences of higher adiposity uncoupled from its adverse metabolic effects14:30-14:45 Raymond Noordam, Leiden University Medical Center, Leiden, The NetherlandsAn exposure-wide Mendelian Randomization on insulin- and noninsulin-dependent diabetes mellitus in UK Biobank reveals different risk profiles14:45-15:00 Maria Carolina Borges, MRC Integrative Epidemiology Unit, UKLiver function and risk of type 2 diabetes: bidirectional Mendelian randomization study15:00-15:15 Reagan Mogire KEMRI-Wellcome Trust Research Programme, Kenya Vitamin D status and the risk of malaria and bacterial infections - a Mendelian randomization study15:15-15:30 Charli Stoneman, University of Exeter Medial School, University of Exeter, UKMechanistic mendelian randomisation - variants in epo and elgn to understand the efficacy and potential side effects of daprodustat14:00-14:30 Jean Baptist Pingault*, University College London, UKIllustrating challenges of triangulation in genetically informed designs: the example of reciprocal relationships between ADHD and BMI14:30-14:45 Bochao Danae Lin, UMC Utrecht, The Netherlands Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable, bidirectional Mendelian Randomization study14:45-15:00 Christina Dardani Centre of Academic Mental Health, University of Bristol, Bristol, UKDifferential causal associations of genetic liability to ADHD and Autism with educational attainment: Evidence from a two-sample Mendelian randomization study15:00-15:15 Michel Nivard, VU University Amsterdam, The NetherlandsA GWAS of non-cognitive skills in Genomic SEM facilitates MR analysis of an unmeasured phenotype15:15-15:30 Denis Baird, MRC Integrative Epidemiology Unit, UKIdentifying the tissue-specific influence of gene expression on neurological and psychiatric traits14:00-14:30 Adam Butterworth*, University of Cambridge, UKTitle: TBC14:30-14:45 Katherine Ruth, University of Exeter Medical School, Exeter, UKGenetically-predicted menopause timing reveals changes in HRT use as a result of adverse health effects reported in 200214:45-15:00 Shruti Kanzaria, Bristol medical school, University of Bristol, UKProteome-wide Mendelian randomization study identified 12 potential drug targets for psychiatric diseases15:00-15:15 Danielle Rasooly, Department of Biomedical Informatics, Harvard Medical School, USAAntidiabetic drug effects on genetically predicted glycemic traits and their concordance in a real-world observational health insurance claims cohort from the United States15:15-15:30 Dylan Williams Karolinska Institute, SwedenCan lipid-lowering drugs be repurposed for the prevention of neurodegenerative diseases? A target validation study using Mendelian randomisation15:30 – 16:00 Break16:00 Sessions 16, 17, 1816. Adjusting for biasLecture Theatre 117. Behavioural and psychiatric traits Lecture Theatre 218. Maternal and early life environmentLecture Theatre 3Chair: Frank Dudbridge, Department of Health Sciences, University of Leicester, UKChair: Jean Baptist Pingault, University College London, UKChair: Rachel Freathy, Institute of Biomedical and Clinical Science, University of Exeter, UK16:00-16:15 Venexia Walker, MRC Integrative Epidemiology Unit, UKThe consequences of adjusting genome-wide association studies on two-sample Mendelian randomization16:15-16:30 Jessica Tyrrell, University of Exeter Medical School, Exeter, UKParticipation in the optional components of the UK Biobank is causally influenced by many traits16:30-16:45 Osama Mahmoud, MRC Integrative Epidemiology Unit, UK A robust method for index-event bias correction in genome-wide association of subsequent traits16:00-16:30 Jorien Treur*, Department of Psychiatry, University of Amsterdam, The NetherlandsInvestigating causal pathways between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization16:30-16:45 Sean Harrison, MRC Integrative Epidemiology Unit, UK The Causal Effects of Health and Health-Risk Behaviours on Social and Economic Outcomes in UK Biobank16:45-17:00 Louise Millard, MRC Integrative Epidemiology Unit, UK MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging16:00-16:15 Jian Zhao, MRC Integrative Epidemiology Unit, UK Investigating causal effect of maternal pregnancy circulating amino acids on offspring birthweight: a two-sample Mendelian randomisation study16:15-16:30 Rita Pereira, Erasmus School of Economics, The NetherlandsGene-Environment Interactions in Weight: the impact of in-utero exposure to nicotine16:30-16:45 Maria Magnus, Norwegian Institute of Public Health, Norway and MRC Integrative Epidemiology Unit, UKIdentifying potential effects of age at menarche: a phenome-wide Mendelian randomization analysis16:45-17:00 Joshua Bell, MRC Integrative Epidemiology Unit, UKInfluence of puberty timing on adiposity and cardiometabolic traits: Mendelian randomization study using repeated measures data17:00-18:00 Poster session 4Friday 19th July, 20199:00 Session 19, Lecture Theatre 1Chair: Rebecca Richmond, MRC Integrative Epidemiology Unit, UK9:00-9:30 Professor Aroon Hingorani*, University College London Mendelian randomisation, drug development and therapeutics9:30-9:45 Meda Sandu, MRC Integrative Epidemiology Unit, UKTwo-step randomisation: applying the results of small feasibility studies of interventions to large-scale Mendelian randomisation studies to robustly infer causal effects on clinical endpoints9:45-10:00 Veronika Skrivankova, Institute of Social and preventive Medicine, University of Bern, SwitzerlandSTROBE-MR reporting guidelines10:00 -10:20 Break10:20 Session 20: MR Data Challenge Chair: Jack Bowden, MRC Integrative Epidemiology Unit, UK10:20-10:45 Michael Holmes*, University of Oxford, UK Lipid related measurements and vascular disease 10.45-11:00 Verena Zuber, Department of Epidemiology and Biostatistics, Imperial College London and MRC Biostatistics Unit, Cambridge, UK Selecting causal risk factors from high-throughput experiments using multivariable Mendelian randomization-6413516510011:00-11:42 Data challenge 6-minute mini talks Challenge Entry 1: Carolina Borges Challenge Entry 2: Qingyuan Zhao Challenge Entry 3: Eleanor Sanderson Challenge Entry 4: Apostolos Gktazionis Challenge Entry 5: Okezie Uche-Ikonne Challenge Entry 6: Daniel Long Challenge Entry 7: Chin Yang Shapland 11:42-11:50 Discussion, debate, prize giving11:50 Session 21, Lecture Theatre 1Chair: Professor George Davey Smith, MRC Integrative Epidemiology Unit, UK11:50-12:20 Keynote lecture – Ewan Birney*Title: TBC12:20 Prize giving and close 12:30: Lunch13:30 – 16:30 MR-Base WorkshopRoom E20413:30: 16:30 Mediation workshopLecture Theatre 3 ................
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