A diagnostic serum-test as a non-invasive approach for ...
Update: November 2011
A diagnostic serum-test as a non-invasive approach for early detection of breast cancer in women with familial or genetic predisposition.
Dr. Wilma Mesker en Prof. Rob Tollenaar.
Department of Surgery, Leiden University Medical Center.
Research questions:
There is need to improve screening for early detection of breast cancer. In population screening with standard mammography one out of five cancer cases is missed. In surveillance of (hereditary) high risk groups considerable numbers of interval cancers
are reported as well as screen detected lesions with unfavorable size. Family history is one of the most powerful risk factors in breast cancer development.
Hereditary breast cancer accounts for up to 5-10% of all breast carcinomas with two high-penetrance genes (BRCA1 and BRCA2) responsible for about 16% of the familial risk of breast cancer cases and associated with an 87% lifetime risk for a mutation carrier. Early detection strategies are considered to address this heightened risk.
The purpose of a screening program is to identify breast cancer at an early stage before metastatic spread. The survival of women diagnosed with breast cancers ................
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