ZYN : THE FUTURE OF NICOTINE; TOBACCO FREE NICOTINE …

ZYN?: THE FUTURE OF NICOTINE; TOBACCO FREE NICOTINE PODS

Dr. Johan Lindholm

Director Analytical & Product Science

Dr. Mikael Staaf

Manager Product Science

Dr. Lars E. Rutqvist

Senior Vice President Scientific Affairs

Thord Hassler

Vice President R&D

1

THE EVOLUTION OF NICOTINE

Cigarettes

Smokeless

Pouches

Snus

E-cig/Vape

Next Gen

Nicotine of choice for decades

Health warnings emerged in 1960's

Smoking restrictions introduced in 1970's

Smokers begin looking for more discrete alternatives to smoking that still satisfy.

No smoke = more discrete than smoking

Provided consumers with an option as smoking restrictions expanded

Many smokers didn't like the mouth feel or spitting associated with STP

STP oral health warnings issued in 1980's

More convenient and easier to use appealed to more smokers

More discrete than loose smokeless tobacco

More discrete than moist snuff/pouches

No spitting required

General snus was first product approved for Pre-Market Tobacco Product Application (PMTA) by FDA

First non-tobacco nicotine products emerge

Inhaled nicotine vapor, not tobacco

Vapor clouds still identify user as a smoker, less discrete than snus

Vape restrictions first appear in 2010's

Next gen products for consumers must be:

- Smokeless - Spitless - Discrete - Convenient - Tobacco Free - Recreational

Most importantly, next gen products must satisfy and meet a wide variety of consumer preferences

* A. McNeill, et al., Public Health England (2015), publications gateway: 2015260

D.J. Nutt, et al., Eur Addict Res (2014); 20: 218?225

Ii-Lun Chen, CTP presentation, Society for Research on Nicotine and Tobacco, Chicago, USA (2016)

2

VOLUME DEVELOPMENT FOR CIGARETTES AND SNUS IN SWEDEN AND NORWAY

1916 1923 1930 1937 1944 1951 1958 1965 1972 1979 1986 1993 2000 2007 2014

Cigarettes

(million packs)

700 630 560 490 420 350 280 210 140

70 0

Sweden

Cigarettes 1973: First Snus

portion snus launched

Snus

(million cans)

250 225 200 175 150 125 100 75 50 25 0

35 30 25 20 15 10

5 0

1985

Norway

Share of population (%)

Cigarette smokers

Snus users

1990

1995

2000

2005

2010

SNUS IS OUTPERFORMING CIGARETTES IN SWEDEN AND NORWAY

Source Sweden: SMD Logistics and Swedish Match estimates

Source Norway: The Norwegian Directorate of Health

3

RECORD LOW PREVALENCE OF SMOKING IN SWEDEN

Proportion of daily cigarette smokers (percentage of population aged 15 and over)

40% 35% 30% 25% 20% 15% 10%

5% 0%

Source: Special Eurobarometer 458, European Commission 4

...IS MIRRORED IN THE PUBLIC HEALTH STATISTICS...LOWEST INCIDENCE OF TOBACCO RELATED CANCER

90

Lung cancer among men in Europe

80

Incidence ASR (W) , new cases per 100,000 males Source: WHO/IARC, 2008

70

60

50

40

30

20

10

0

35

Oral and pancreatic cancer combined among men in Europe

30

Incidence ASR (W) , new cases per 100,000 males Source: WHO/IARC, 2008

25

20

15

10

5

0

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