My research focuses on increased ... - University of Florida



Mark S. Segal, M.D., Ph.D.

Assistant Professor

Nephrology, Hypertension & Renal Transplantation

University of Florida College of Medicine

1600 SW Archer Rd.,

PO BOX 100224

Gainesville, FL 32610

Phone: 352 3924008

Office:

E-Mail: segalms@medicine.ufl.edu

Publications: Search PubMed

My research focuses on mechanisms for the increased cardiovascular disease in patients with diabetes, chronic kidney disease, systemic lupus erythematosus (SLE), and women who have preeclampsia or preterm delivery. My hypothesis is that a key determinate of whether an individual will develop chronic kidney disease or atherosclerosis is the ability of the individual’s endothelium to tolerate their level of blood pressure, glycemia, or other stressors to the endothelium.

We have taken two tracts to test this hypothesis. One is to understand sensitizing factors to apoptosis and the other is to develop assays to assess in vivo endothelial cell health. My laboratory developed an assay to assess endothelial damage using circulating endothelial cells and an assay to assess endothelial repair, using endothelial progenitor cells. We were the first to describe that circulating endothelial cells were increased in chronic states of increased endothelial injury and that an increased number of circulating endothelial cells predicted an increased probability of a cardiovascular event in patients with end-stage renal disease. We in collaboration with Dr. Maria Grant of the Department of Pharmacology and Therapeutics and Dr. Roger Tran-Son-Tay of Department of Mechanical & Aerospace Engineering found that endothelial progenitor cells isolated from diabetic patients are defective in migration and are rigid. More importantly, we found that the migration defect is reversible by increasing the nitric oxide levels within these cells. We are also investigating the mechanism by which multiple medications affect endothelial progenitor cell function as a means to accelerate endothelial repair. More recently in collaboration with Dr. Kirk Conrad we have demonstrating that endothelial progenitor cells migrate to the pregnancy hormone relaxin. We are currently investigating the numbers of endothelial progenitor cells in women with an elevated level of relaxin and no circulating relaxin during their pregnancies.

To fully investigate the role of endothelial progenitor cells, we are determining their role in a novel mouse model of venous intimal hyperplasia. In addition, we are investigating the mechanism of decreased endothelial progenitor cells in lupus patients and whether this can be the mechanism for their known increased cardiovascular risk. The importance and uniqueness of this work, as compared to utilizing other mechanisms of determining endothelial health, is that it can actually dissect at the cellular level the cause for poor endothelial function.

Research Support

Ongoing Research Support

Alliance for Lupus Research (Segal) 8/15/2007 - 8/14/2009 NCE

ALLIANCE FOR LUPUS RESEARCH “ACCELERATED ATHEROSCLEROSIS IN SLE: THE TYPE I INTERFERON LINK”

THIS PROJECT INVESTIGATES THE ROLE OF IFN-α IN THE EXCESS CARDIOVASCULAR RISK IN PATIENTS WITH SLE. THERE IS NO OVERLAP BETWEEN THIS GRANT AND THE SUBMITTED PROPOSAL.

NIH R01 PIS: SEGAL/PEPINE

“ANCILLARY FUNCTIONAL STUDIES FOR THE CCTRN”

INVESTIGATE THE CHARACTERISTICS OF CELLS USED IN THE CCTRN TRIALS THAT ARE PREDICTIVE OF OUTCOME.

NIH R01 1U01DK082189-01 PI: HUBER (CO-I SEGAL) 9/10/2008-5/31/2013

"MODULATION OF THE HEMODYNAMIC FACTORS ASSOCIATED WITH AVF MATURATION".

UF WAS SELECTED TO DEVELOP A MULTICENTER OBSERVATIONAL COHORT STUDY TO IDENTIFY PREDICTORS OF AVF MATURATION/NON-MATURATION.

NIH/NHLBI R01 HL079352 (SEGAL) 08/01/2005 - 04/30/2009

URIC ACID AND HYPERTENSION IN AFRICAN AMERICANS

EVALUATES THE EFFECT ON BLOOD PRESSURE AND ENDOTHELIAL FUNCTION OF SIMULTANEOUSLY TREATING AFRICAN AMERICANS, WITH ALLOPURINOL ALONG WITH A DIURETIC. THERE IS NO OVERLAP BETWEEN THIS GRANT AND THE SUBMITTED PROPOSAL.

NIH/NIDDK “PRE AND POSTDOCTORAL TRAINING IN NEPHROLOGY AND HYPERTENSION” (1T32DK07518-17)

Principal Investigator: Segal 7/1/07-6/30/12

The objective of this grant is to provide training of predoctoral and postdoctoral candidates into basic and clinical research related to nephrology with the purpose of providing the necessary training to become independent investigators

NHLBI CCTRN-Site (PI: Pepine; PI project 1: Segal)

UF WAS CHOSEN AS ONE OF ONLY FIVE SITES IN THE US TO BE IN THE CARDIOVASCULAR CELL THERAPY RESEARCH NETWORK. THERE IS NO OVERLAP BETWEEN THIS GRANT AND THE SUBMITTED PROPOSAL

2 R01 EY012601-08A1 (GRANT; CO-I: SEGAL) 07/01/2006 - 06/30/2010 NIH/NEI

ENDOTHELIAL PRECURSOR DYSFUNCTION IN DEVELOPMENT OF DIABETIC ACELLULAR CAPILLARIES

THIS PROJECT INVESTIGATES THE ROLE OF ENDOTHELIAL PROGENITOR CELLS IN THE DEVELOPMENT OF DIABETIC RETINOPATHY. THERE IS NO OVERLAP BETWEEN THIS GRANT AND THE SUBMITTED PROPOSAL.

PUBLICATIONS

INDUCTION OF NITRIC OXIDE BY ERYTHROPOIETIN IS MEDIATED BY THE β COMMON RECEPTOR AND REQUIRES INTERACTION WITH VEGF RECEPTOR 2. SAUTINA L, SAUTIN Y, BEEM E, ZHOU Z, SCHULER A, BRENNAN J, ZHARIKOV SI, DIAO Y, BUNGERT J, SEGAL MS. BLOOD. 2009 NOV 20.

ENDOTHELIAL PROGENITOR CELLS AND ENDOTHELIAL VESICLES – WHAT IS THE SIGNIFICANCE FOR PATIENTS WITH CHRONIC KIDNEY DISEASE? RAHESH MOHANDAS & MARK S.SEGAL. BLOOD PURIFICATION. 2010. 29:175-179.

INDUCTION OF NITRIC OXIDE BY ERYTHROPOIETIN IS MEDIATED BY THE β COMMON RECEPTOR AND REQUIRES INTERACTION WITH VEGF RECEPTOR 2. LARYSA SAUTINA, YURI SAUTIN, ELAINE BEEM, ZHUO ZHOU, ANNA SCHULER, JENNAFER BRENNAN, SERGEY I. ZHARIKOV, YANPENG DIAO, JORG BUNGERT, AND MARK S. SEGAL. BLOOD IN PRESS.

ACUTE KIDNEY INJURY IS ASSOCIATED WITH INCREASED LONG-TERM MORTALITY AFTER CARDIOTHORACIC SURGERY. HOBSON CE, YAVAS S, SEGAL MS, SCHOLD JD, TRIBBLE CG, LAYON AJ, BIHORAC A. CIRCULATION. 2009 MAY 12;119(18):2444-53. EPUB 2009 APR 27.

LONG-TERM RISK OF MORTALITY AND ACUTE KIDNEY INJURY DURING HOSPITALIZATION AFTER MAJOR SURGERY. BIHORAC A, YAVAS S, SUBBIAH S, HOBSON CE, SCHOLD JD, GABRIELLI A, LAYON AJ, SEGAL MS. ANN SURG. 2009 APR 21.

LAMBDA CHOPS: CREATION OF SITE-DIRECTED MUTANTS IN INSERTABLE FRAGMENTS UTILIZING GATEWAY((R)) TECHNOLOGY. BEEM JE, LEE P, SEGAL MS. MOL BIOTECHNOL. 2009 MAR 20.

KOSUGI T, HEINIG M, NAKAYAMA T, CONNOR T, YUZAWA Y, LI Q, HAUSWIRTH WW, GRANT MB, CROKER BP, CAMPBELL-THOMPSON M, ZHANG L, ATKINSON MA, SEGAL MS, NAKAGAWA T. LOWERING BLOOD PRESSURE BLOCKS MESANGIOLYSIS AND MESANGIAL NODULES, BUT NOT TUBULOINTERSTITIAL INJURY, IN DIABETIC ENOS KNOCKOUT MICE. AM J PATHOL. 2009 FEB 26. [EPUB AHEAD OF PRINT]

JOHNSON RJ, PEREZ-POZO SE, SAUTIN YY, MANITIUS J, SANCHEZ-LOZADA LG, FEIG DI, SHAFIU M, SEGAL M, GLASSOCK RJ, SHIMADA M, RONCAL C, NAKAGAWA T. HYPOTHESIS: COULD EXCESSIVE FRUCTOSE INTAKE AND URIC ACID CAUSE TYPE 2 DIABETES? ENDOCR REV. 2009 FEB;30(1):96-116. EPUB 2009 JAN 16.

LI Y, LEE PY, SOBEL ES, NARAIN S, SATOH M, SEGAL MS, REEVES WH, RICHARDS HB. INCREASED EXPRESSION OF FCGAMMARI/CD64 ON CIRCULATING MONOCYTES PARALLELS ONGOING INFLAMMATION AND NEPHRITIS IN LUPUS. ARTHRITIS RES THER. 2009 JAN 14;11(1):R6. [EPUB AHEAD OF PRINT]

KIM KM, HENDERSON GN, FRYE RF, GALLOWAY CD, BROWN NJ, SEGAL MS, IMARAM W, ANGERHOFER A, JOHNSON RJ. SIMULTANEOUS DETERMINATION OF URIC ACID METABOLITES ALLANTOIN, 6-AMINOURACIL, AND TRIURET IN HUMAN URINE USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY. J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2009 JAN 1;877(1-2):65-70. EPUB 2008 NOV 25.

GARIN EH, DIAZ LN, MU W, WASSERFALL C, ARAYA C, SEGAL M, JOHNSON RJ.

URINARY CD80 EXCRETION INCREASES IN IDIOPATHIC MINIMAL-CHANGE DISEASE. J AM SOC NEPHROL. 2009 FEB;20(2):260-6. EPUB 2008 DEC 3.

LI CALZI S, PURICH DL, CHANG KH, AFZAL A, NAKAGAWA T, BUSIK JV, AGARWAL A, SEGAL MS, GRANT MB. CARBON MONOXIDE AND NITRIC OXIDE MEDIATE CYTOSKELETAL REORGANIZATION IN MICROVASCULAR CELLS VIA VASODILATOR-STIMULATED PHOSPHOPROTEIN PHOSPHORYLATION: EVIDENCE FOR BLUNTED RESPONSIVENESS IN DIABETES. DIABETES. 2008 SEP;57(9):2488-94. EPUB 2008 JUN 16.

DIAO, Y., GUTHRIE, S., XIA, S.L., OUYANG, S., ZHANG, L., XUE, J., LEE, P., GRANT, M., SCOTT, E., SEGAL, M.S. LONG-TERM ENGRAFTMENT OF BONE MARROW DERIVED-CELLS IN THE INTIMAL HYPERPLASIA LESION OF AUTOLOGOUS VEIN GRAFTS. AM J PATHOL. 2008 MAR;172(3):839-48. EPUB 2008 FEB 14.

SEGAL MS, GOLLUB E, JOHNSON RJ. IS THE FRUCTOSE INDEX MORE RELEVANT WITH REGARDS TO CARDIOVASCULAR DISEASE THAN THE GLYCEMIC INDEX? EUR J NUTR. 2007 OCT;46(7):406-17. EPUB 2007 SEP 1.

JOHNSON RJ, SEGAL MS, SAUTIN Y, NAKAGAWA T, FEIG DI, KANG DH, GERSCH MS, BENNER S, SANCHEZ-LOZADA LG. POTENTIAL ROLE OF SUGAR (FRUCTOSE) IN THE EPIDEMIC OF HYPERTENSION, OBESITY AND THE METABOLIC SYNDROME, DIABETES, KIDNEY DISEASE, AND CARDIOVASCULAR DISEASE. AM J CLIN NUTR. 2007 OCT;86(4):899-906.

LEE, P., LI, Y., RICHARDS, H.B., CHAN, F.S., ZHUANG, H., NARAIN, S., BUTFILOSKI, E., SOBEL, E.S., REEVES, W.H., SEGAL, M.S. TYPE I INTERFERON: A NOVEL RISK FACTOR FOR EPC DEPLETION AND ENDOTHELIAL DYSFUNCTION IN SLE. ARTHRITIS & RHEUMATISM. 2007 NOV;56(11):3759-69.

SEGAL MS, GOLLUB E, JOHNSON RJ. IS THE FRUCTOSE INDEX MORE RELEVANT WITH REGARDS TO CARDIOVASCULAR DISEASE THAN THE GLYCEMIC INDEX? EUR J NUTR. SEPTEMBER, 2007. [EPUB AHEAD OF PRINT]

AFZAL A, SHAW LC, LJUBIMOV AV, BOULTON ME, SEGAL MS, GRANT MB. RETINAL AND CHOROIDAL MICROANGIOPATHIES: THERAPEUTIC OPPORTUNITIES.

MICROVASC RES. MAY, 2007. [EPUB AHEAD OF PRINT]

YAMASAKI Y, NARAIN S, YOSHIDA H, HERNANDEZ L, BARKER T, HAHN PC, SOBEL ES, SEGAL MS, RICHARDS HB, CHAN EK, REEVES WH, SATOH M. AUTOANTIBODIES TO RNA HELICASE A: A NEW SEROLOGIC MARKER OF EARLY LUPUS. ARTHRITIS RHEUM. 2007 FEB;56(2):596-604.

SHAH R, BEEM E, SAUTINA L, ZHARIKOV SI, SEGAL MS. MITOMYCIN- AND CALCINEURIN-ASSOCIATED HUS, ENDOTHELIAL DYSFUNCTION AND ENDOTHELIAL REPAIR: A NEW PARADIGM FOR THE PUZZLE? NEPHROL DIAL TRANSPLANT. 2006 OCT 13;

LI Y, TUCCI M, NARAIN S, BARNES EV, SOBEL ES, SEGAL MS, RICHARDS HB. URINARY BIOMARKERS IN LUPUS NEPHRITIS. AUTOIMMUN REV. 2006 JUL;5(6):383-8.

YAMASAKI Y, NARAIN S, HERNANDEZ L, BARKER T, IKEDA K, SEGAL MS, RICHARDS HB, CHAN EK, REEVES WH, SATOH M. AUTOANTIBODIES AGAINST THE REPLICATION PROTEIN A COMPLEX IN SYSTEMIC LUPUS ERYTHEMATOSUS AND OTHER AUTOIMMUNE DISEASES. ARTHRITIS RES THER. 2006 JUL 17;8(4):R111.

NAKAGAWA T, KANG DH, FEIG D, SANCHEZ-LOZADA LG, SRINIVAS TR, SAUTIN Y, EJAZ AA, SEGAL M, JOHNSON RJ. UNEARTHING URIC ACID: AN ANCIENT FACTOR WITH RECENTLY FOUND SIGNIFICANCE IN RENAL AND CARDIOVASCULAR DISEASE.

KIDNEY INT. 2006 MAY;69(10):1722-5.

SEGAL MS, BAYLIS C, JOHNSON RJ. ENDOTHELIAL HEALTH AND DIVERSITY IN THE KIDNEY. J AM SOC NEPHROL. 2006 JAN 18.

SEGAL, MARK S., BAYLIS, CHRIS, JOHNSON, RICHARD J. ENDOTHELIAL HEALTH AND DIVERSITY IN THE KIDNEY. J AM SOC NEPHROL. 2006 FEB;17(2):323-4.

SEGAL, MARK S., SHAH, RONAK, AFZAL, AQEELA, CABALLERO, SERGIO, KOC, MEHMET, HARRISON, JEFFREY K., GRANT, MARIA B. NITRIC OXIDE CYTOSKELETAL-INDUCED ALTERATIONS REVERSE THE ENDOTHELIAL PROGENITOR CELL MIGRATORY DEFECT ASSOCIATED WITH DIABETES. DIABETES. 2006. 55(1):102-9.

LEE PY, SCUMPIA PO, BYARS JA, KELLY KM, ZHUANG H, SHUSTER JS, THERIAQUE DW, SEGAL MS, REEVES WH, BRANTLY ML. SHORT-TERM ATORVASTATIN TREATMENT ENHANCES SPECIFIC ANTIBODY PRODUCTION FOLLOWING TETANUS TOXOID VACCINATION IN HEALTHY VOLUNTEERS. VACCINE. 2006 JAN 9.

ZHUANG H, NARAIN S, SOBEL E, LEE PY, NACIONALES DC, KELLY KM, RICHARDS HB, SEGAL M, STEWART C, SATOH M, REEVES WH. ASSOCIATION OF ANTI-NUCLEOPROTEIN AUTOANTIBODIES WITH UPREGULATION OF TYPE I INTERFERON-INDUCIBLE GENE TRANSCRIPTS AND DENDRITIC CELL MATURATION IN SYSTEMIC LUPUS ERYTHEMATOSUS. CLIN IMMUNOL. 2005 DEC;117(3):238-50.

ZHUANG H, NARAIN S, SOBEL E, LEE PY, NACIONALES DC, KELLY KM, RICHARDS HB, SEGAL M, STEWART C, SATOH M, REEVES WH. ASSOCIATION OF ANTI-NUCLEOPROTEIN AUTOANTIBODIES WITH UPREGULATION OF TYPE I INTERFERON-INDUCIBLE GENE TRANSCRIPTS AND DENDRITIC CELL MATURATION IN SYSTEMIC LUPUS ERYTHEMATOSUS. CLIN IMMUNOL. 2005 AUG 24

BARNES EV, NARAIN S, NARANJO A, SHUSTER J, SEGAL MS, SOBEL ES, REEVES WH, RICHARDS HB. HIGH SENSITIVITY C-REACTIVE PROTEIN IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATION TO DISEASE ACTIVITY AND CLINICAL PRESENTATION. LUPUS, 2005, 14:576.

DIAO, YANPENG, XUE, JING, SEGAL, MARK S. A NOVEL MURINE MODEL OF INTIMAL HYPERPLASIA INDUCED BY AUTOLOGOUS VENOUS GRAFT INTO THE AORTA. IN PRESS JOURNAL OF SURGICAL RESEARCH.

CHEN, SIFENG, SEGAL, MARK, AGARWAL, ANUPAM. "A SIMPLE "LUMEN DIGESTION" TECHNIQUE FOR ISOLATION OF AORTIC ENDOTHELIAL CELLS FROM HEME OXYGENASE-1 KNOCKOUT MICE." BIOTECHNIQUES. 37:84-89.

KOC, MEHMET, RICHARDS, HANNO, BIHORAC, AZRA, ROSS, ED, SCHOLD, JESSE, AND SEGAL, MARK S. (2005). CIRCULATING ENDOTHELIAL CELLS ARE A UNIQUE INDICATOR OF MORBIDITY AND MORTALITY IN HEMODIALYSIS PATIENTS. KIDNEY INT. MAR;67(3):1078-83.

BUTLER JM, GUTHRIE SM, KOC M, AFZAL A, CABALLERO S, BROOKS HL, MAMES RN, SEGAL MS, GRANT MB, SCOTT EW. (2005). SDF-1 IS BOTH NECESSARY AND SUFFICIENT TO PROMOTE PROLIFERATIVE RETINOPATHY. J CLIN INVEST. JAN;115(1):86-93.

BROOKS HL JR, CABALLERO S JR, NEWELL CK, STEINMETZ RL, WATSON D, SEGAL MS, HARRISON JK, SCOTT EW, GRANT MB. (2004). VITREOUS LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND STROMAL-DERIVED FACTOR 1 IN PATIENTS WITH DIABETIC RETINOPATHY AND CYSTOID MACULAR EDEMA BEFORE AND AFTER INTRAOCULAR INJECTION OF TRIAMCINOLONE. ARCH OPHTHALMOL. 122(12):1801-7.

LEE P, SEGAL MS. (2004). REAL-TIME ANALYSIS OF APOPTOSIS IN VIVO. METHODS CELL BIOL. 75:343-54.

BEEM, ELAINE, HOLLIDAY, SHANNON, AND SEGAL, MARK S. FORMATION OF THE 1.4 MD APOPTOSOME IS AN ESSENTIAL INTERMEDIATE IN THE FORMATION OF ACTIVE APOPTOSOMES. AJP:CELL. SEP;287(3):C664-72.

SRINIVAS, TITTE R., HERRERA-ACOSTA, JAIME, FEIG, DANIEL I., KANG, DUK-HEE, SEGAL, MARK S., AND JOHNSON, RICHARD J. (2004). DIURETIC-INDUCED HYPERURICEMIA DOES NOT DECREASE CARDIOVASCULAR RISK. JOURNAL OF HYPERTENSION. 22:1–3.

TUCCI, M., E. BARNES, E.S. SOBEL, B.P. CROKER, M.S. SEGAL, W. REEVES, AND H. RICHARDS. (2004). A FUNCTIONAL POLYMORPHISM IN THE MONOCYTE CHEMOATTRACTANT PROTEIN (MCP) - 1 PROMOTER GENE IS STRONGLY ASSOCIATED WITH LUPUS NEPHRITIS. ARTHRITIS & RHEUMATISM, 2004. 50(6):1842-9.

JOCHIMSEN F, GRUENING W, ARNOULD T, SEGAL MS, KRUSKALL MS, COLGROVE R JR, WALZ G. (2004). THROMBOTIC MICROANGIOPATHY ASSOCIATED WITH UNUSUAL VIRAL SEQUENCES IN HIV-1-POSITIVE PATIENTS. NEPHROL DIAL TRANSPLANT. 19(5):1129-35.

KOC, MEHMET, BIHORAC, AZRA, AND SEGAL, MARK S. (2003). CIRCULATING ENDOTHELIAL CELLS AS A POTENTIAL MARKER OF A DYSFUNCTIONAL ENDOTHELIUM IN HEMODIALYSIS PATIENTS. AJKD. 42(4):704-12.

AGARWAL, ANUPAM AND SEGAL, MARK S. (2003). INTIMAL EXUBERANCE: VEINS IN JEOPARDY. COMMENTARY. AMERICAN JOURNAL OF PATHOLOGY. 162(6):1759-1761.

LEE, PUI, BEEM, ELAINE, AND SEGAL, MARK S. (2002). REAL-TIME EVALUATION OF IN-VIVO CASPASE ACTIVITY. BIOTECHNIQUES. 33(6):1284-7, 1289-91.

SEGAL, MARK S., BIHORAC, AZRA, AND KOC, MEHMET. (2002). CIRCULATING ENDOTHELIAL CELLS: TEA LEAVES FOR RENAL DISEASE. INVITED REVIEW. AM J RENAL PHYSIOL. 283(1):F11-9.

SEGAL, MARK S. AND BEEM, ELAINE. (2001). EFFECT OF PH, IONIC CHARGE AND OSMOLALITY ON CYTOCHROME C MEDIATED CASPASE-3 ACTIVITY. AM J CELL PHYSIOL. 281:C1196-11204.

LU, H., DHANABAL, M., VOLK, R., WATERMAN, M.J., RAMCHANDRAN, R., KNEBELMANN B., SEGAL, M., SUKHATME, V.P. (1999). KRINGLE 5 CAUSES CELL CYCLE ARREST AND APOPTOSIS OF ENDOTHELIAL CELLS. BIOCHEM BIOPHYS RES COMMUN. 258(3):668-673.

DHANABAL M., RAMCHANDRAN R., WATERMAN M.J., LU H., KNEBELMANN B., SEGAL M., SUKHATME V.P. (1999). ENDOSTATIN INDUCES ENDOTHELIAL CELL APOPTOSIS. J BIOL CHEM. 274(17):11721-11726.

RAMCHANDRAN R., DHANABAL M., VOLK R., WATERMAN M.J., SEGAL M., LU H., KNEBELMANN B., SUKHATME, V.P. (1999). ANTIANGIOGENIC ACTIVITY OF RESTIN, NC10 DOMAIN OF HUMAN COLLAGEN XV: COMPARISON TO ENDOSTATIN. BIOCHEM BIOPHYS RES COMMUN. 255(3):735-739.

GETHING, M.J., BLOND-ELGUINDI, S., BUCHNER, J., FOURIE, A., KNARR, G., MODROW, S., NANU, L., SEGAL, M., SAMBROOK, J. (1995). BINDING SITES FOR HSP70 MOLECULAR CHAPERONES IN NATURAL PROTEINS. COLD SPRING HARB SYMP QUANT BIOLOGY. 60:417-428.

SMITH, JW AND SEGAL, M. (1994). URINARY TRACT INFECTION IN MEN--AN INTERNIST'S VIEWPOINT. INFECTION. 22:S31-4.

SEGAL, M.S., BYE, J.M., SAMBROOK, J.F., AND GETHING M.J. (1992). DISULFIDE BOND FORMATION DURING THE FOLDING OF INFLUENZA VIRUS HEMAGGLUTININ. J. CELL BIOLOGY. 118:227-244.

KOZUTSUMI, Y., SEGAL, M. NORMINGTON, K., GETHING, M.J., AND SAMBROOK, J. (1988). THE PRESENCE OF MALFOLDED PROTEINS IN THE ENDOPLASMIC RETICULUM SIGNALS THE INDUCTION OF GLUCOSE-REGULATED PROTEINS. NATURE. 332:462-464.

KINGSLEY, D., KOZARSKY, K., SEGAL, M., AND KRIEGER, M. (1986). THREE TYPES OF LOW DENSITY LIPOPROTEIN RECEPTOR DEFICIENT MUTANTS HAVE PLEIOTROPIC DEFECTS IN THE SYNTHESIS OF N LINKED, O LINKED, AND LIPID LINKED CARBOHYDRATE CHAINS. J. CELL BIOLOGY. 102:1576 1585.

KRIEGER, M., MARTIN, J., SEGAL, M., AND KINGSLEY, D. (1983). AMPHOTERICIN B SELECTION OF MUTANT CHINESE HAMSTER CELLS WITH DEFECTS IN THE RECEPTOR MEDIATED ENDOCYTOSIS OF LOW DENSITY LIPOPROTEIN AND CHOLESTEROL BIOSYNTHESIS. PNAS. 80:5607 5611.

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