INTRODUCTION - Imperial College London
, 2013). At a molecular striatal level, PDE-10A regulates cAMP and cGMP downstream signaling cascades (e.g. cAMP/PKA/DARPP-32) that control the phosphorylation state and activity of several physiological effectors including gene transcription factors such as CREB, and various neurotransmitter receptors and voltage-gated ion channels (Nishi . et al. ................
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